Ensembl Gene ID Gene Start (bp) Gene End (bp) GO Term Accession (bp) GO Term Name (bp) GO Term Definition (bp) GO Term Evidence Code (bp) GO Term Accession (cc) GO Term Name GO Term Definition (cc) GO Term Evidence Code (cc) GO Term Definition (mf) GO Term Evidence Code (mf) GO Term Accession (mf) GO Term Name (mf) GSVIVG01030133001 10124569 10129564 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01007870001 8144795 8155931 GSVIVG01002499001 35063853 35064445 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01014166001 1015625 1018257 GSVIVG01012936001 13836304 13837228 Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides. IEA GO:0004866 endopeptidase inhibitor activity GSVIVG01011116001 1450336 1451646 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01036737001 23172291 23185359 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01036737001 23172291 23185359 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01036737001 23172291 23185359 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: phosphoenolpyruvate + D-arabinose 5-phosphate + H2O = 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate. IEA GO:0008676 3-deoxy-8-phosphooctulonate synthase activity GSVIVG01036737001 23172291 23185359 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: phosphoenolpyruvate + D-arabinose 5-phosphate + H2O = 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate. IEA GO:0008676 3-deoxy-8-phosphooctulonate synthase activity GSVIVG01026250001 14851574 14852877 GO:0006829 zinc ion transport The directed movement of zinc (Zn) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. IEA GO:0005385 zinc ion transmembrane transporter activity GSVIVG01026250001 14851574 14852877 GO:0006829 zinc ion transport The directed movement of zinc (Zn) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. IEA GO:0005385 zinc ion transmembrane transporter activity GSVIVG01026250001 14851574 14852877 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. IEA GO:0005385 zinc ion transmembrane transporter activity GSVIVG01026250001 14851574 14852877 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. IEA GO:0005385 zinc ion transmembrane transporter activity GSVIVG01026250001 14851574 14852877 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. IEA GO:0005385 zinc ion transmembrane transporter activity GSVIVG01026250001 14851574 14852877 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. IEA GO:0005385 zinc ion transmembrane transporter activity GSVIVG01026250001 14851574 14852877 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. IEA GO:0005385 zinc ion transmembrane transporter activity GSVIVG01026250001 14851574 14852877 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. IEA GO:0005385 zinc ion transmembrane transporter activity GSVIVG01026250001 14851574 14852877 GO:0006829 zinc ion transport The directed movement of zinc (Zn) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01026250001 14851574 14852877 GO:0006829 zinc ion transport The directed movement of zinc (Zn) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01026250001 14851574 14852877 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01026250001 14851574 14852877 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01026250001 14851574 14852877 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01026250001 14851574 14852877 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01026250001 14851574 14852877 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01026250001 14851574 14852877 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01026250001 14851574 14852877 GO:0006829 zinc ion transport The directed movement of zinc (Zn) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01026250001 14851574 14852877 GO:0006829 zinc ion transport The directed movement of zinc (Zn) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01026250001 14851574 14852877 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01026250001 14851574 14852877 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01026250001 14851574 14852877 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01026250001 14851574 14852877 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01026250001 14851574 14852877 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01026250001 14851574 14852877 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01017038001 3689567 3694785 GSVIVG01015396001 3263059 3268345 GSVIVG01024152001 736293 738636 GSVIVG01017825001 3809768 3819769 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA GSVIVG01009896001 12216225 12219253 GO:0007049 cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01009896001 12216225 12219253 GO:0007049 cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01009896001 12216225 12219253 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01009896001 12216225 12219253 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01009896001 12216225 12219253 GO:0051301 cell division The process resulting in the physical partitioning and separation of a cell into daughter cells. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01009896001 12216225 12219253 GO:0051301 cell division The process resulting in the physical partitioning and separation of a cell into daughter cells. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01009896001 12216225 12219253 GO:0007049 cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01009896001 12216225 12219253 GO:0007049 cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01009896001 12216225 12219253 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01009896001 12216225 12219253 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01009896001 12216225 12219253 GO:0051301 cell division The process resulting in the physical partitioning and separation of a cell into daughter cells. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01009896001 12216225 12219253 GO:0051301 cell division The process resulting in the physical partitioning and separation of a cell into daughter cells. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01037154001 28531707 28533746 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01037154001 28531707 28533746 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01037154001 28531707 28533746 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01037154001 28531707 28533746 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01011375001 29133260 29136407 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01011375001 29133260 29136407 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01011375001 29133260 29136407 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01011375001 29133260 29136407 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01011375001 29133260 29136407 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024696001 7660435 7661925 GO:0006829 zinc ion transport The directed movement of zinc (Zn) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. IEA GO:0005385 zinc ion transmembrane transporter activity GSVIVG01024696001 7660435 7661925 GO:0006829 zinc ion transport The directed movement of zinc (Zn) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. IEA GO:0005385 zinc ion transmembrane transporter activity GSVIVG01024696001 7660435 7661925 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. IEA GO:0005385 zinc ion transmembrane transporter activity GSVIVG01024696001 7660435 7661925 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. IEA GO:0005385 zinc ion transmembrane transporter activity GSVIVG01024696001 7660435 7661925 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. IEA GO:0005385 zinc ion transmembrane transporter activity GSVIVG01024696001 7660435 7661925 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. IEA GO:0005385 zinc ion transmembrane transporter activity GSVIVG01024696001 7660435 7661925 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. IEA GO:0005385 zinc ion transmembrane transporter activity GSVIVG01024696001 7660435 7661925 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. IEA GO:0005385 zinc ion transmembrane transporter activity GSVIVG01024696001 7660435 7661925 GO:0006829 zinc ion transport The directed movement of zinc (Zn) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01024696001 7660435 7661925 GO:0006829 zinc ion transport The directed movement of zinc (Zn) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01024696001 7660435 7661925 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01024696001 7660435 7661925 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01024696001 7660435 7661925 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01024696001 7660435 7661925 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01024696001 7660435 7661925 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01024696001 7660435 7661925 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01024696001 7660435 7661925 GO:0006829 zinc ion transport The directed movement of zinc (Zn) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01024696001 7660435 7661925 GO:0006829 zinc ion transport The directed movement of zinc (Zn) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01024696001 7660435 7661925 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01024696001 7660435 7661925 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01024696001 7660435 7661925 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01024696001 7660435 7661925 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01024696001 7660435 7661925 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01024696001 7660435 7661925 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01019959001 12361151 12366147 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019959001 12361151 12366147 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019959001 12361151 12366147 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA A ligand-dependent receptor found in the nucleus of the cell. IEA GO:0004879 ligand-dependent nuclear receptor activity GSVIVG01019959001 12361151 12366147 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA A ligand-dependent receptor found in the nucleus of the cell. IEA GO:0004879 ligand-dependent nuclear receptor activity GSVIVG01019959001 12361151 12366147 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01019959001 12361151 12366147 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01025872001 10943294 10948994 GO:0019941 modification-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01025872001 10943294 10948994 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01025872001 10943294 10948994 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01025872001 10943294 10948994 GO:0019941 modification-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01025872001 10943294 10948994 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01025872001 10943294 10948994 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01000668001 20568426 20576019 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with follicle-stimulating hormone to initiate a change in cell activity. IEA GO:0004963 follicle-stimulating hormone receptor activity GSVIVG01000668001 20568426 20576019 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with follicle-stimulating hormone to initiate a change in cell activity. IEA GO:0004963 follicle-stimulating hormone receptor activity GSVIVG01003729001 7459065 7460444 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01003729001 7459065 7460444 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01036992001 9153204 9160193 GSVIVG01021163001 2051979 2083832 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01021163001 2051979 2083832 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01021163001 2051979 2083832 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01021163001 2051979 2083832 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate, driving the unwinding of the DNA helix. IEA GO:0004003 ATP-dependent DNA helicase activity GSVIVG01021163001 2051979 2083832 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01021163001 2051979 2083832 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021163001 2051979 2083832 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01021163001 2051979 2083832 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01007575001 11783303 11799500 GSVIVG01004912001 4752553 4755341 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01004912001 4752553 4755341 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01004912001 4752553 4755341 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01004912001 4752553 4755341 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01004912001 4752553 4755341 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029077001 11976259 11986353 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01029077001 11976259 11986353 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01029077001 11976259 11986353 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01029077001 11976259 11986353 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01034199001 14487267 14490596 GSVIVG01023061001 16041879 16042025 GSVIVG01030147001 10292978 10309237 GSVIVG01029582001 21156194 21159002 GSVIVG01014954001 12834089 12834905 GSVIVG01012250001 150382 175544 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012250001 150382 175544 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012250001 150382 175544 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012250001 150382 175544 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01012250001 150382 175544 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01012250001 150382 175544 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01012250001 150382 175544 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01012250001 150382 175544 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01012250001 150382 175544 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01032040001 23271095 23284065 GSVIVG01013567001 21017108 21042799 GSVIVG01009970001 12936464 12938187 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01009970001 12936464 12938187 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01009970001 12936464 12938187 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01009970001 12936464 12938187 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01035771001 4166328 4177492 GSVIVG01012686001 641937 648890 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01012686001 641937 648890 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01012686001 641937 648890 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01012686001 641937 648890 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01012686001 641937 648890 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01012686001 641937 648890 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01012686001 641937 648890 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012686001 641937 648890 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009996001 13277542 13280722 GSVIVG01015101001 1046317 1057712 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01029227001 18301061 18305467 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004185 serine-type carboxypeptidase activity GSVIVG01017658001 2414688 2417615 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01019945001 12652935 12655438 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01017521001 9864534 9867263 GSVIVG01034830001 22331771 22347176 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01034830001 22331771 22347176 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01034830001 22331771 22347176 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01024875001 6318844 6320916 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024875001 6318844 6320916 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. IEA GO:0004722 protein serine/threonine phosphatase activity GSVIVG01011950001 2714899 2717647 GSVIVG01009759001 11035476 11042060 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01031262001 700134 708115 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain. IEA GO:0004177 aminopeptidase activity GSVIVG01031262001 700134 708115 GO:0009987 cellular process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. IEA Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain. IEA GO:0004177 aminopeptidase activity GSVIVG01031262001 700134 708115 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008235 metalloexopeptidase activity GSVIVG01031262001 700134 708115 GO:0009987 cellular process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008235 metalloexopeptidase activity GSVIVG01031262001 700134 708115 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with manganese (Mn) ions. IEA GO:0030145 manganese ion binding GSVIVG01031262001 700134 708115 GO:0009987 cellular process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. IEA Interacting selectively and non-covalently with manganese (Mn) ions. IEA GO:0030145 manganese ion binding GSVIVG01017094001 4118713 4121700 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01017094001 4118713 4121700 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01033818001 17491887 17497258 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GSVIVG01019981001 12038070 12043051 GSVIVG01032539001 28173464 28179067 GSVIVG01011036001 2068629 2072022 GSVIVG01005733001 13937999 13940132 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01022424001 19997457 19998284 GSVIVG01010956001 2664035 2668904 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of potassium ions (K+) from one side of a membrane to the other. IEA GO:0015079 potassium ion transmembrane transporter activity GSVIVG01009569001 9504328 9510875 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GSVIVG01011468001 29867639 29889682 GSVIVG01023138001 22156390 22172457 GSVIVG01038705001 20812479 20816151 GSVIVG01006329001 24906696 24915772 GSVIVG01005931001 22818745 22821612 GSVIVG01037941001 11208037 11230670 GO:0009052 pentose-phosphate shunt, non-oxidative branch The branch of the pentose-phosphate shunt which does not involve oxidation reactions. It comprises a series of sugar phosphate interconversions, starting with ribulose 5-P and producing fructose 6-P and glyceraldehyde 3-P. IEA Catalysis of the reaction: D-ribose 5-phosphate = D-ribulose 5-phosphate. IEA GO:0004751 ribose-5-phosphate isomerase activity GSVIVG01017694001 2697638 2700935 GSVIVG01024692001 7678925 7681681 GSVIVG01017672001 2525137 2528540 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01008619001 359709 361734 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01034075001 15366086 15368427 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005875 microtubule associated complex Any multimeric complex connected to a microtubule. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01016073001 18375794 18378055 GSVIVG01013999001 8703806 8708897 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01021971001 4920869 4929014 GSVIVG01023694001 9433190 9436264 GSVIVG01026115001 24392227 24428896 GSVIVG01018008001 5436488 5437596 GO:0006869 lipid transport The directed movement of lipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Interacting selectively and non-covalently with a lipid. IEA GO:0008289 lipid binding GSVIVG01002783001 36402396 36405150 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01037768001 7696808 7699656 GSVIVG01035768001 4149581 4155798 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035768001 4149581 4155798 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035747001 3873222 3875153 GSVIVG01035425001 1204313 1209560 GSVIVG01033304001 21667263 21670454 GSVIVG01017203001 5315328 5316004 GSVIVG01013724001 8196427 8202028 GSVIVG01033059001 25420782 25427043 GSVIVG01018636001 11897458 11913092 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018636001 11897458 11913092 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01014121001 557585 558549 GSVIVG01003992001 14127215 14135474 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01003992001 14127215 14135474 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01010125001 15898501 15900732 GSVIVG01017902001 4495886 4502434 GSVIVG01001742001 715352 716174 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01023653001 8559380 8567857 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01017160001 4863860 4868287 GSVIVG01025993001 26170918 26175509 GSVIVG01014518001 4723054 4725550 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA GSVIVG01015724001 16414993 16420516 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004197 cysteine-type endopeptidase activity GSVIVG01014210001 1489145 1494170 Interacting selectively and non-covalently with a specific domain of a protein. IEA GO:0019904 protein domain specific binding GSVIVG01035407001 1067344 1068214 GSVIVG01007771001 9221632 9223623 GSVIVG01016886001 2260682 2264915 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) All non-F1 subunits of the mitochondrial hydrogen-transporting ATP synthase, including integral and peripheral mitochondrial inner membrane proteins. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01000192001 16016095 16017421 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01000192001 16016095 16017421 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01000192001 16016095 16017421 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01000192001 16016095 16017421 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01010353001 19729451 19730764 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01004745001 15814541 15829577 GSVIVG01026624001 20937354 20940134 GO:0006535 cysteine biosynthetic process from serine The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026624001 20937354 20940134 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026624001 20937354 20940134 GO:0006535 cysteine biosynthetic process from serine The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01026624001 20937354 20940134 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01027718001 7076729 7078360 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01027718001 7076729 7078360 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01027718001 7076729 7078360 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01027718001 7076729 7078360 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009665001 10309576 10313870 GO:0006351 transcription, DNA-dependent The cellular synthesis of RNA on a template of DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01009665001 10309576 10313870 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01009665001 10309576 10313870 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01009665001 10309576 10313870 GO:0006351 transcription, DNA-dependent The cellular synthesis of RNA on a template of DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01009665001 10309576 10313870 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01009665001 10309576 10313870 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01009665001 10309576 10313870 GO:0006351 transcription, DNA-dependent The cellular synthesis of RNA on a template of DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01009665001 10309576 10313870 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01009665001 10309576 10313870 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01009665001 10309576 10313870 GO:0006351 transcription, DNA-dependent The cellular synthesis of RNA on a template of DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01009665001 10309576 10313870 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01009665001 10309576 10313870 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01036308001 3657972 3671752 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01036308001 3657972 3671752 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01033052001 25360483 25368380 GSVIVG01019588001 1792282 1793558 GSVIVG01003969001 26388551 26392658 GSVIVG01018634001 11946598 11950417 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029267001 17793689 17799507 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GSVIVG01019687001 2469923 2473615 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01019687001 2469923 2473615 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01019687001 2469923 2473615 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01019687001 2469923 2473615 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01028922001 17499473 17503681 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000037001 2969327 2974847 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + (R)-mevalonate = ADP + (R)-5-phosphomevalonate. IEA GO:0004496 mevalonate kinase activity GSVIVG01000037001 2969327 2974847 GO:0008299 isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + (R)-mevalonate = ADP + (R)-5-phosphomevalonate. IEA GO:0004496 mevalonate kinase activity GSVIVG01000037001 2969327 2974847 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + (R)-mevalonate = ADP + (R)-5-phosphomevalonate. IEA GO:0004496 mevalonate kinase activity GSVIVG01000037001 2969327 2974847 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000037001 2969327 2974847 GO:0008299 isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000037001 2969327 2974847 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000037001 2969327 2974847 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01000037001 2969327 2974847 GO:0008299 isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01000037001 2969327 2974847 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01000037001 2969327 2974847 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01000037001 2969327 2974847 GO:0008299 isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01000037001 2969327 2974847 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01006372001 25328753 25331535 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01006372001 25328753 25331535 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01006372001 25328753 25331535 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01038702001 20829567 20831385 GSVIVG01034665001 7376290 7391272 GSVIVG01031804001 4488820 4491489 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01016513001 3243623 3245888 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01016513001 3243623 3245888 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01016513001 3243623 3245888 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01016513001 3243623 3245888 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01016513001 3243623 3245888 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016513001 3243623 3245888 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01027359001 15881966 15885323 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Stops, prevents or reduces the activity of an enzyme. IEA GO:0004857 enzyme inhibitor activity GSVIVG01027359001 15881966 15885323 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01027359001 15881966 15885323 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the reaction: pectin + n H2O = n methanol + pectate. IEA GO:0030599 pectinesterase activity GSVIVG01027359001 15881966 15885323 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue. IEA GO:0045330 aspartyl esterase activity GSVIVG01036699001 23634533 23683391 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024135001 866406 867024 GSVIVG01028874001 17911251 17919834 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01028874001 17911251 17919834 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01028874001 17911251 17919834 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01028874001 17911251 17919834 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01029896001 1066341 1073252 GSVIVG01014727001 9010621 9015289 GSVIVG01015392001 3245946 3247764 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01015392001 3245946 3247764 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01038480001 10137657 10139644 GSVIVG01003202001 7832202 7852989 GSVIVG01016427001 4022717 4035660 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01017263001 6062959 6064943 GSVIVG01010886001 16330326 16331157 GSVIVG01031727001 3866770 3872492 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GSVIVG01021107001 1487056 1489521 GSVIVG01017806001 3607219 3608355 GSVIVG01004960001 17069277 17087406 GSVIVG01027981001 2951289 2956272 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01027981001 2951289 2956272 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01023987001 1914435 1914955 GSVIVG01009043001 4494501 4504409 GSVIVG01013222001 6621102 6629838 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01013222001 6621102 6629838 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01013222001 6621102 6629838 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01013222001 6621102 6629838 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01013222001 6621102 6629838 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01013222001 6621102 6629838 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01013222001 6621102 6629838 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01013222001 6621102 6629838 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01013222001 6621102 6629838 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01013222001 6621102 6629838 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01013222001 6621102 6629838 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013222001 6621102 6629838 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013222001 6621102 6629838 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013222001 6621102 6629838 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013222001 6621102 6629838 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013222001 6621102 6629838 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01013222001 6621102 6629838 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01013222001 6621102 6629838 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01013222001 6621102 6629838 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01013222001 6621102 6629838 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01000397001 725321 732119 GSVIVG01007654001 10820978 10825022 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01021386001 4782434 4783991 GSVIVG01029455001 22661652 22661747 GSVIVG01023142001 22085554 22093086 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01023142001 22085554 22093086 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01023142001 22085554 22093086 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01023142001 22085554 22093086 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01010628001 15848819 15855307 GSVIVG01009374001 7874253 7878811 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009374001 7874253 7878811 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. IEA GO:0004722 protein serine/threonine phosphatase activity GSVIVG01026421001 23750423 23756493 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01019090001 16788070 16801485 GO:0051252 regulation of RNA metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA. IEA Stops, prevents or reduces the activity of a ribonuclease, any enzyme that catalyzes the hydrolysis of phosphodiester bonds in chains of RNA. IEA GO:0008428 ribonuclease inhibitor activity GSVIVG01018664001 11491301 11491585 GSVIVG01038346001 13335859 13336296 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01038346001 13335859 13336296 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01038346001 13335859 13336296 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01028661001 11788433 11791884 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01028661001 11788433 11791884 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01028661001 11788433 11791884 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015934 large ribosomal subunit The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01032004001 23649470 23654104 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032004001 23649470 23654104 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01032004001 23649470 23654104 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01031992001 23700261 23712903 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031992001 23700261 23712903 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031992001 23700261 23712903 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031992001 23700261 23712903 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031770001 4254510 4260217 GSVIVG01029499001 22241839 22243818 GSVIVG01028610001 10718957 10722208 GO:0009690 cytokinin metabolic process The chemical reactions and pathways involving cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028610001 10718957 10722208 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028610001 10718957 10722208 GO:0009690 cytokinin metabolic process The chemical reactions and pathways involving cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01028610001 10718957 10722208 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01028610001 10718957 10722208 GO:0009690 cytokinin metabolic process The chemical reactions and pathways involving cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators. IEA Catalysis of the reaction: N6-dimethylallyladenine + acceptor + H2O = adenine + 3-methylbut-2-enal + reduced electron acceptor. IEA GO:0019139 cytokinin dehydrogenase activity GSVIVG01028610001 10718957 10722208 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: N6-dimethylallyladenine + acceptor + H2O = adenine + 3-methylbut-2-enal + reduced electron acceptor. IEA GO:0019139 cytokinin dehydrogenase activity GSVIVG01028610001 10718957 10722208 GO:0009690 cytokinin metabolic process The chemical reactions and pathways involving cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01028610001 10718957 10722208 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01036668001 20024428 20026244 GSVIVG01007554001 12208441 12210355 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01007554001 12208441 12210355 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01015378001 3130716 3133943 GSVIVG01014067001 74012 75110 GSVIVG01009218001 6335984 6343462 GSVIVG01024870001 6342434 6344806 GSVIVG01032944001 24492483 24497975 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01018660001 11534090 11543377 GSVIVG01017681001 2592613 2596009 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01017681001 2592613 2596009 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01017681001 2592613 2596009 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01017681001 2592613 2596009 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036834001 17736461 17738276 GSVIVG01008726001 1464152 1468615 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01019054001 17297745 17299565 GSVIVG01030144001 10238375 10250990 GSVIVG01012918001 13442116 13442208 GSVIVG01009591001 9706002 9713560 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01009591001 9706002 9713560 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01009591001 9706002 9713560 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01009591001 9706002 9713560 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01012894001 6573039 6575848 GSVIVG01008122001 5600225 5602845 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01008122001 5600225 5602845 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01008122001 5600225 5602845 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01008122001 5600225 5602845 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01036917001 17661210 17662826 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01034537001 19698453 19699507 GSVIVG01034146001 14844802 14847375 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01034146001 14844802 14847375 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01034146001 14844802 14847375 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01034146001 14844802 14847375 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01034146001 14844802 14847375 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01034146001 14844802 14847375 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01003751001 12360977 12368334 GSVIVG01031822001 4701572 4707486 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01031822001 4701572 4707486 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01029948001 2001342 2010468 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01035666001 3145704 3151567 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01035666001 3145704 3151567 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01035666001 3145704 3151567 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01035666001 3145704 3151567 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01035666001 3145704 3151567 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01035666001 3145704 3151567 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01035362001 763542 764099 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GSVIVG01035362001 763542 764099 GO:0009607 response to biotic stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism. IEA GSVIVG01023953001 2208257 2209744 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01023953001 2208257 2209744 Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. IEA GO:0008171 O-methyltransferase activity GSVIVG01023953001 2208257 2209744 The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01012488001 13804450 13805055 GSVIVG01020335001 21167540 21173705 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with transfer RNA. IEA GO:0000049 tRNA binding GSVIVG01020335001 21167540 21173705 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe). IEA GO:0004826 phenylalanine-tRNA ligase activity GSVIVG01020335001 21167540 21173705 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01005817001 22072629 22075050 GSVIVG01020418001 19775640 19783293 GSVIVG01013860001 5440478 5442027 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035061001 1251026 1252742 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GSVIVG01035061001 1251026 1252742 GO:0009607 response to biotic stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism. IEA GSVIVG01021787001 7430388 7436427 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01014051001 10082752 10090378 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014051001 10082752 10090378 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014051001 10082752 10090378 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014051001 10082752 10090378 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01014051001 10082752 10090378 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036614001 19253666 19257709 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036614001 19253666 19257709 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036614001 19253666 19257709 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036614001 19253666 19257709 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023883001 2732048 2737839 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01031926001 5445686 5454159 GSVIVG01028395001 7064176 7066440 GSVIVG01034594001 14781777 14783175 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01034594001 14781777 14783175 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01017208001 5435903 5439446 GSVIVG01000884001 3441043 3442545 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000884001 3441043 3442545 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007699001 10241880 10248968 GSVIVG01032173001 21831534 21832550 GSVIVG01038087001 17849972 17876784 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01038087001 17849972 17876784 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01006663001 27321706 27322005 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. IEA GO:0008137 NADH dehydrogenase (ubiquinone) activity GSVIVG01006663001 27321706 27322005 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. IEA GO:0008137 NADH dehydrogenase (ubiquinone) activity GSVIVG01006663001 27321706 27322005 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. IEA GO:0008137 NADH dehydrogenase (ubiquinone) activity GSVIVG01006663001 27321706 27322005 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01006663001 27321706 27322005 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01006663001 27321706 27322005 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01015460001 3880663 3883710 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01015460001 3880663 3883710 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01015460001 3880663 3883710 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01015460001 3880663 3883710 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01015460001 3880663 3883710 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025170001 3765452 3775573 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025170001 3765452 3775573 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01025170001 3765452 3775573 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01025170001 3765452 3775573 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01016680001 330864 339616 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01016680001 330864 339616 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016680001 330864 339616 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01011930001 2928989 2935188 GSVIVG01033602001 19400129 19405474 GSVIVG01020612001 3778166 3780152 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01013142001 7717272 7720036 GSVIVG01021959001 5076406 5081015 GO:0006801 superoxide metabolic process The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01021959001 5076406 5081015 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01031253001 770141 787118 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031253001 770141 787118 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031253001 770141 787118 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031253001 770141 787118 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031253001 770141 787118 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01031253001 770141 787118 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01026027001 25645181 25647652 GSVIVG01018038001 5731876 5738598 GO:0019509 L-methionine salvage from methylthioadenosine The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01018038001 5731876 5738598 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01018038001 5731876 5738598 GO:0019509 L-methionine salvage from methylthioadenosine The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine. IEA Catalysis of the incorporation of both atoms of oxygen from one molecule of O2 into the (reduced) product(s) of the reaction. The two atoms of oxygen may be distributed between two different products. IEA GO:0051213 dioxygenase activity GSVIVG01018038001 5731876 5738598 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of both atoms of oxygen from one molecule of O2 into the (reduced) product(s) of the reaction. The two atoms of oxygen may be distributed between two different products. IEA GO:0051213 dioxygenase activity GSVIVG01022471001 3480167 3481138 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01020089001 10422536 10423558 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GSVIVG01009867001 11940705 11948275 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01034897001 16209619 16218061 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01034897001 16209619 16218061 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01034897001 16209619 16218061 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01016088001 18700315 18704061 GSVIVG01014054001 10130028 10130591 GSVIVG01010304001 19229546 19230041 GSVIVG01009752001 10990248 10993974 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01031202001 1208563 1215182 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01031202001 1208563 1215182 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end. IEA GO:0004527 exonuclease activity GSVIVG01017232001 5737378 5739561 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017232001 5737378 5739561 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017232001 5737378 5739561 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017232001 5737378 5739561 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019619001 2012750 2013969 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019619001 2012750 2013969 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01019825001 3662068 3666803 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005663 DNA replication factor C complex A complex of five polypeptides in eukaryotes, and two in prokaryotes, that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01019825001 3662068 3666803 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005663 DNA replication factor C complex A complex of five polypeptides in eukaryotes, and two in prokaryotes, that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019825001 3662068 3666803 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005663 DNA replication factor C complex A complex of five polypeptides in eukaryotes, and two in prokaryotes, that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their closing around the DNA duplex. IEA GO:0003689 DNA clamp loader activity GSVIVG01019825001 3662068 3666803 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005663 DNA replication factor C complex A complex of five polypeptides in eukaryotes, and two in prokaryotes, that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019825001 3662068 3666803 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005663 DNA replication factor C complex A complex of five polypeptides in eukaryotes, and two in prokaryotes, that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01007433001 31862407 31862886 GSVIVG01014570001 5275677 5279667 GSVIVG01023292001 20038469 20045514 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01023292001 20038469 20045514 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01023292001 20038469 20045514 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01023292001 20038469 20045514 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01024914001 6080875 6084644 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01024914001 6080875 6084644 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01005170001 18954833 18959026 GSVIVG01009964001 12879999 12882177 GSVIVG01022339001 18628550 18651547 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01022339001 18628550 18651547 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01022339001 18628550 18651547 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01022339001 18628550 18651547 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01000095001 3469943 3481958 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with manganese (Mn) ions. IEA GO:0030145 manganese ion binding GSVIVG01000095001 3469943 3481958 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Functions in the storage of nutritious substrates. IEA GO:0045735 nutrient reservoir activity GSVIVG01020321001 21381109 21382737 GSVIVG01007342001 31446423 31448049 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01007342001 31446423 31448049 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01007342001 31446423 31448049 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01007342001 31446423 31448049 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011055001 1945736 1947730 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01037434001 13809432 13816870 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01037434001 13809432 13816870 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01037434001 13809432 13816870 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01037434001 13809432 13816870 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01012947001 14123816 14125018 GSVIVG01011800001 4036759 4039540 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01011800001 4036759 4039540 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01011800001 4036759 4039540 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01011800001 4036759 4039540 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01011687001 5123104 5124512 GSVIVG01018480001 14530656 14532182 GSVIVG01037219001 27828676 27848734 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01037219001 27828676 27848734 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01037219001 27828676 27848734 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01037219001 27828676 27848734 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01037219001 27828676 27848734 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01037219001 27828676 27848734 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01037219001 27828676 27848734 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01037219001 27828676 27848734 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01037219001 27828676 27848734 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01037219001 27828676 27848734 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01037219001 27828676 27848734 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01037219001 27828676 27848734 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01037219001 27828676 27848734 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037219001 27828676 27848734 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037219001 27828676 27848734 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037219001 27828676 27848734 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037219001 27828676 27848734 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01037219001 27828676 27848734 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01037219001 27828676 27848734 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01037219001 27828676 27848734 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01030315001 9037590 9039572 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01023968001 2060587 2066331 GO:0006836 neurotransmitter transport The directed movement of a neurotransmitter into, out of, within or between cells by means of some external agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. IEA GO:0005887 integral to plasma membrane Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in). IEA GO:0005328 neurotransmitter:sodium symporter activity GSVIVG01023968001 2060587 2066331 GO:0006836 neurotransmitter transport The directed movement of a neurotransmitter into, out of, within or between cells by means of some external agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in). IEA GO:0005328 neurotransmitter:sodium symporter activity GSVIVG01023968001 2060587 2066331 GO:0006836 neurotransmitter transport The directed movement of a neurotransmitter into, out of, within or between cells by means of some external agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in). IEA GO:0005328 neurotransmitter:sodium symporter activity GSVIVG01023968001 2060587 2066331 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0005887 integral to plasma membrane Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in). IEA GO:0005328 neurotransmitter:sodium symporter activity GSVIVG01023968001 2060587 2066331 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in). IEA GO:0005328 neurotransmitter:sodium symporter activity GSVIVG01023968001 2060587 2066331 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in). IEA GO:0005328 neurotransmitter:sodium symporter activity GSVIVG01023968001 2060587 2066331 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0005887 integral to plasma membrane Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in). IEA GO:0005328 neurotransmitter:sodium symporter activity GSVIVG01023968001 2060587 2066331 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in). IEA GO:0005328 neurotransmitter:sodium symporter activity GSVIVG01023968001 2060587 2066331 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in). IEA GO:0005328 neurotransmitter:sodium symporter activity GSVIVG01023968001 2060587 2066331 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005887 integral to plasma membrane Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in). IEA GO:0005328 neurotransmitter:sodium symporter activity GSVIVG01023968001 2060587 2066331 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in). IEA GO:0005328 neurotransmitter:sodium symporter activity GSVIVG01023968001 2060587 2066331 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in). IEA GO:0005328 neurotransmitter:sodium symporter activity GSVIVG01023968001 2060587 2066331 GO:0006836 neurotransmitter transport The directed movement of a neurotransmitter into, out of, within or between cells by means of some external agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. IEA GO:0005887 integral to plasma membrane Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01023968001 2060587 2066331 GO:0006836 neurotransmitter transport The directed movement of a neurotransmitter into, out of, within or between cells by means of some external agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01023968001 2060587 2066331 GO:0006836 neurotransmitter transport The directed movement of a neurotransmitter into, out of, within or between cells by means of some external agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01023968001 2060587 2066331 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0005887 integral to plasma membrane Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01023968001 2060587 2066331 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01023968001 2060587 2066331 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01023968001 2060587 2066331 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0005887 integral to plasma membrane Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01023968001 2060587 2066331 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01023968001 2060587 2066331 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01023968001 2060587 2066331 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005887 integral to plasma membrane Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01023968001 2060587 2066331 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01023968001 2060587 2066331 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01020332001 21197352 21198117 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01020332001 21197352 21198117 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N2-methylguanine. IEA GO:0004809 tRNA (guanine-N2-)-methyltransferase activity GSVIVG01024340001 1191110 1192037 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01024340001 1191110 1192037 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01038025001 16448662 16459547 GSVIVG01033969001 16215877 16219307 GSVIVG01032406001 27065714 27065815 GSVIVG01011463001 29808305 29813645 GSVIVG01023592001 7742860 7744214 GSVIVG01008261001 3886868 3898796 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01008261001 3886868 3898796 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01008261001 3886868 3898796 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01008261001 3886868 3898796 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01008539001 1004068 1010002 Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum. IEA GO:0003993 acid phosphatase activity GSVIVG01008539001 1004068 1010002 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01008539001 1004068 1010002 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01020831001 1438517 1440021 Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01021552001 6956455 6957702 The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01033043001 25291947 25302576 GSVIVG01020623001 3677509 3679119 Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. IEA GO:0008171 O-methyltransferase activity GSVIVG01010248001 18308819 18320345 GSVIVG01031485001 18033994 18036569 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01027582001 15345713 15352669 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01013441001 438422 443080 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01003483001 10660019 10661097 GSVIVG01033437001 20688400 20695482 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01033437001 20688400 20695482 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01033437001 20688400 20695482 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033437001 20688400 20695482 Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01029733001 13845705 13880286 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01019355001 577888 580626 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01019355001 577888 580626 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01009592001 9714080 9725445 GSVIVG01013460001 263665 297925 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008013001 6686593 6693719 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. IEA GO:0004364 glutathione transferase activity GSVIVG01010166001 16623443 16639232 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01010166001 16623443 16639232 GO:0006171 cAMP biosynthetic process The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01010166001 16623443 16639232 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01010166001 16623443 16639232 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate. IEA GO:0004016 adenylate cyclase activity GSVIVG01010166001 16623443 16639232 GO:0006171 cAMP biosynthetic process The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). IEA Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate. IEA GO:0004016 adenylate cyclase activity GSVIVG01010166001 16623443 16639232 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate. IEA GO:0004016 adenylate cyclase activity GSVIVG01010166001 16623443 16639232 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010166001 16623443 16639232 GO:0006171 cAMP biosynthetic process The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010166001 16623443 16639232 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010166001 16623443 16639232 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: ATP + D-ribulose 5-phosphate = ADP + D-ribulose 1,5-bisphosphate. IEA GO:0008974 phosphoribulokinase activity GSVIVG01010166001 16623443 16639232 GO:0006171 cAMP biosynthetic process The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). IEA Catalysis of the reaction: ATP + D-ribulose 5-phosphate = ADP + D-ribulose 1,5-bisphosphate. IEA GO:0008974 phosphoribulokinase activity GSVIVG01010166001 16623443 16639232 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: ATP + D-ribulose 5-phosphate = ADP + D-ribulose 1,5-bisphosphate. IEA GO:0008974 phosphoribulokinase activity GSVIVG01010166001 16623443 16639232 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01010166001 16623443 16639232 GO:0006171 cAMP biosynthetic process The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01010166001 16623443 16639232 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01010166001 16623443 16639232 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01010166001 16623443 16639232 GO:0006171 cAMP biosynthetic process The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01010166001 16623443 16639232 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01035695001 3391703 3393275 GSVIVG01008455001 1833037 1848019 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019931001 4544176 4560881 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01019931001 4544176 4560881 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019931001 4544176 4560881 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015489001 4152758 4154110 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01015489001 4152758 4154110 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01015489001 4152758 4154110 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01015489001 4152758 4154110 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000345001 11795553 11801564 GSVIVG01036420001 4928023 4928124 GSVIVG01001142001 22973510 22982647 GSVIVG01033155001 8597276 8598256 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033155001 8597276 8598256 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01016373001 4389034 4393566 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the removal of a phosphate group from phosphorylated myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol. IEA GO:0004437 inositol or phosphatidylinositol phosphatase activity GSVIVG01016373001 4389034 4393566 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3. IEA GO:0042578 phosphoric ester hydrolase activity GSVIVG01036886001 18220533 18246437 GSVIVG01029863001 699341 704592 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01001915001 7159526 7163058 GSVIVG01022308001 18385274 18388330 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01022308001 18385274 18388330 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01022308001 18385274 18388330 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01022308001 18385274 18388330 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01022308001 18385274 18388330 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01022308001 18385274 18388330 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01022308001 18385274 18388330 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01022308001 18385274 18388330 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01022308001 18385274 18388330 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01022308001 18385274 18388330 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01022308001 18385274 18388330 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01022308001 18385274 18388330 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01022308001 18385274 18388330 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01022308001 18385274 18388330 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01022308001 18385274 18388330 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01022328001 18535826 18540512 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion. IEA GO:0004806 triglyceride lipase activity GSVIVG01001362001 24000394 24003260 GSVIVG01009019001 4329435 4329641 GSVIVG01030170001 10877084 10877929 GSVIVG01026618001 20985266 20986429 GSVIVG01035029001 1016082 1018547 GO:0000272 polysaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01035029001 1016082 1018547 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01035029001 1016082 1018547 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01035029001 1016082 1018547 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01035029001 1016082 1018547 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01035029001 1016082 1018547 GO:0000272 polysaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01035029001 1016082 1018547 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01035029001 1016082 1018547 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01035029001 1016082 1018547 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01035029001 1016082 1018547 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01035029001 1016082 1018547 GO:0000272 polysaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01035029001 1016082 1018547 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01035029001 1016082 1018547 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01035029001 1016082 1018547 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01035029001 1016082 1018547 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01032877001 5004 10776 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01024392001 2024288 2040221 GSVIVG01010582001 16366711 16368449 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010582001 16366711 16368449 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010582001 16366711 16368449 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010582001 16366711 16368449 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01010582001 16366711 16368449 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01010582001 16366711 16368449 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01010582001 16366711 16368449 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01010582001 16366711 16368449 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01010582001 16366711 16368449 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01010582001 16366711 16368449 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01010582001 16366711 16368449 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01010582001 16366711 16368449 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01035679001 3274431 3276202 GSVIVG01038570001 21785849 21788949 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01038570001 21785849 21788949 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01020857001 945954 948375 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01020857001 945954 948375 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01020857001 945954 948375 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01020857001 945954 948375 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003821001 20426687 20444676 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01003821001 20426687 20444676 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003821001 20426687 20444676 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: 3-alpha(S)-strictosidine = tryptamine + secologanin. IEA GO:0016844 strictosidine synthase activity GSVIVG01024179001 565597 568081 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024179001 565597 568081 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01003760001 12443154 12446383 GSVIVG01037852001 7103281 7114344 GO:0009416 response to light stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01037852001 7103281 7114344 GO:0009416 response to light stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01008052001 6218347 6227878 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: chorismate = isochorismate. IEA GO:0008909 isochorismate synthase activity GSVIVG01029718001 13624911 13636163 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01029718001 13624911 13636163 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01029718001 13624911 13636163 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01029718001 13624911 13636163 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029718001 13624911 13636163 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014925001 12136405 12137703 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014925001 12136405 12137703 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030132 clathrin coat of coated pit The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014925001 12136405 12137703 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014925001 12136405 12137703 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030132 clathrin coat of coated pit The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014925001 12136405 12137703 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014925001 12136405 12137703 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030132 clathrin coat of coated pit The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033743001 18192061 18195774 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01033743001 18192061 18195774 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01023612001 8000711 8014379 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01029496001 22249329 22249484 GSVIVG01013154001 7484242 7487802 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin. IEA GO:0004221 ubiquitin thiolesterase activity GSVIVG01011283001 10534319 10535627 GSVIVG01016802001 1531839 1533688 GSVIVG01016604001 2469471 2474522 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016604001 2469471 2474522 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01016604001 2469471 2474522 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01037027001 8766967 8773391 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037027001 8766967 8773391 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01037027001 8766967 8773391 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor), with the acyl group being converted into alkyl on transfer. IEA GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer GSVIVG01016752001 905705 910401 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016752001 905705 910401 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01031602001 18779197 18794608 GSVIVG01015708001 16133408 16133638 GSVIVG01012626001 181868 184374 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012626001 181868 184374 Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01012085001 1563530 1564825 GSVIVG01037592001 10272192 10279955 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01024210001 256877 259331 GSVIVG01035711001 3516691 3537291 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01035711001 3516691 3537291 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01026086001 24785527 24788535 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01038372001 11260763 11278659 GSVIVG01021120001 1629315 1632889 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01021120001 1629315 1632889 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01021120001 1629315 1632889 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01021120001 1629315 1632889 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01021120001 1629315 1632889 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021120001 1629315 1632889 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015477001 4024220 4033675 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01015477001 4024220 4033675 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01001764001 6225747 6226919 GSVIVG01030086001 9715481 9718638 GO:0006006 glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030086001 9715481 9718638 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030086001 9715481 9718638 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030086001 9715481 9718638 GO:0006006 glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. IEA Catalysis of the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+. IEA GO:0004345 glucose-6-phosphate dehydrogenase activity GSVIVG01030086001 9715481 9718638 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+. IEA GO:0004345 glucose-6-phosphate dehydrogenase activity GSVIVG01030086001 9715481 9718638 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+. IEA GO:0004345 glucose-6-phosphate dehydrogenase activity GSVIVG01030086001 9715481 9718638 GO:0006006 glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01030086001 9715481 9718638 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01030086001 9715481 9718638 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008063001 6148096 6149208 GSVIVG01031205001 1191249 1199707 GO:0006606 protein import into nucleus The directed movement of a protein from the cytoplasm to the nucleus. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031205001 1191249 1199707 GO:0006606 protein import into nucleus The directed movement of a protein from the cytoplasm to the nucleus. IEA GO:0005643 nuclear pore Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031205001 1191249 1199707 GO:0006606 protein import into nucleus The directed movement of a protein from the cytoplasm to the nucleus. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031205001 1191249 1199707 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031205001 1191249 1199707 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005643 nuclear pore Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031205001 1191249 1199707 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031205001 1191249 1199707 GO:0006606 protein import into nucleus The directed movement of a protein from the cytoplasm to the nucleus. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01031205001 1191249 1199707 GO:0006606 protein import into nucleus The directed movement of a protein from the cytoplasm to the nucleus. IEA GO:0005643 nuclear pore Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01031205001 1191249 1199707 GO:0006606 protein import into nucleus The directed movement of a protein from the cytoplasm to the nucleus. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01031205001 1191249 1199707 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01031205001 1191249 1199707 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005643 nuclear pore Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01031205001 1191249 1199707 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01028900001 17682374 17688734 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028900001 17682374 17688734 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028900001 17682374 17688734 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028900001 17682374 17688734 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028900001 17682374 17688734 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028900001 17682374 17688734 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028900001 17682374 17688734 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01028900001 17682374 17688734 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01028900001 17682374 17688734 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01028900001 17682374 17688734 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01028900001 17682374 17688734 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01028900001 17682374 17688734 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01026043001 25355512 25361408 GSVIVG01014423001 3619994 3623415 GSVIVG01006743001 27976182 27983358 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01006743001 27976182 27983358 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024729001 7409856 7414847 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030810001 16421475 16422756 GSVIVG01025426001 885435 885667 GSVIVG01029879001 896425 901951 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01029177001 18936290 18937226 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01029177001 18936290 18937226 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01029177001 18936290 18937226 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01029177001 18936290 18937226 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01029177001 18936290 18937226 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01029177001 18936290 18937226 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01025597001 13733570 13739569 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025597001 13733570 13739569 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025597001 13733570 13739569 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025597001 13733570 13739569 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025597001 13733570 13739569 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025597001 13733570 13739569 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025597001 13733570 13739569 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. IEA GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GSVIVG01025597001 13733570 13739569 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. IEA GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GSVIVG01025597001 13733570 13739569 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. IEA GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GSVIVG01025597001 13733570 13739569 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01025597001 13733570 13739569 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01025597001 13733570 13739569 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01007010001 29729322 29729432 GSVIVG01038033001 16545942 16556452 GSVIVG01009482001 8738657 8742768 GSVIVG01017420001 8294889 8298657 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01017420001 8294889 8298657 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01017420001 8294889 8298657 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017420001 8294889 8298657 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017420001 8294889 8298657 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01017420001 8294889 8298657 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01017420001 8294889 8298657 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01017420001 8294889 8298657 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01035299001 182207 184052 GSVIVG01024379001 1765516 1766905 GSVIVG01012665001 424700 428270 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01012665001 424700 428270 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01012665001 424700 428270 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01012665001 424700 428270 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031077001 21912604 21914386 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01031077001 21912604 21914386 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01031077001 21912604 21914386 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01031077001 21912604 21914386 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01020168001 9478448 9494585 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01028345001 6379934 6399597 GSVIVG01034477001 20718815 20720279 GSVIVG01026009001 25899585 25904349 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01000328001 11422337 11424852 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01000328001 11422337 11424852 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01000008001 2650299 2654390 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01000008001 2650299 2654390 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031646001 19571588 19574196 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031646001 19571588 19574196 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031646001 19571588 19574196 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01004894001 16485859 16492831 GSVIVG01023981001 1941771 1946893 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01017418001 8269596 8289490 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029773001 14468488 14469810 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01029773001 14468488 14469810 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01029773001 14468488 14469810 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01029773001 14468488 14469810 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01005739001 13980195 13980883 GSVIVG01005065001 17856048 17857496 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030452001 5671494 5672756 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01030452001 5671494 5672756 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01030452001 5671494 5672756 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01030452001 5671494 5672756 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01030452001 5671494 5672756 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035288001 69281 78477 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01035288001 69281 78477 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01035288001 69281 78477 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000167001 15809675 15820705 GSVIVG01035722001 3662644 3669042 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035722001 3662644 3669042 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01005124001 18374971 18375969 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01000666001 20564535 20567807 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000666001 20564535 20567807 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000666001 20564535 20567807 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000666001 20564535 20567807 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017369001 7462356 7467165 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01031814001 4642801 4644279 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01031814001 4642801 4644279 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025249001 2714924 2721367 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01025249001 2714924 2721367 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01025249001 2714924 2721367 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01025249001 2714924 2721367 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01025249001 2714924 2721367 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025249001 2714924 2721367 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019042001 17449433 17456409 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01014681001 8566312 8585299 GO:0000272 polysaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01014681001 8566312 8585299 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01014681001 8566312 8585299 GO:0000272 polysaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages. IEA Catalysis of the hydrolysis of 1,4-alpha-glucosidic linkages in polysaccharides so as to remove successive maltose units from the non-reducing ends of the chains. IEA GO:0016161 beta-amylase activity GSVIVG01014681001 8566312 8585299 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of 1,4-alpha-glucosidic linkages in polysaccharides so as to remove successive maltose units from the non-reducing ends of the chains. IEA GO:0016161 beta-amylase activity GSVIVG01014681001 8566312 8585299 GO:0000272 polysaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01014681001 8566312 8585299 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01009909001 12306652 12309400 GSVIVG01013160001 7389084 7392295 GSVIVG01008548001 948282 949180 GSVIVG01000285001 2256357 2263708 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01000285001 2256357 2263708 Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium. IEA GO:0005544 calcium-dependent phospholipid binding GSVIVG01020181001 9345791 9354378 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. IEA GO:0008080 N-acetyltransferase activity GSVIVG01014710001 8891256 8891686 GSVIVG01022194001 17344286 17345000 GSVIVG01000426001 7815430 7818514 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01000426001 7815430 7818514 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01000426001 7815430 7818514 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01000426001 7815430 7818514 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037046001 8411915 8414726 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01037046001 8411915 8414726 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01037046001 8411915 8414726 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01037046001 8411915 8414726 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01037046001 8411915 8414726 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01037046001 8411915 8414726 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01037046001 8411915 8414726 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01037046001 8411915 8414726 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01037046001 8411915 8414726 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01037046001 8411915 8414726 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01037046001 8411915 8414726 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01037046001 8411915 8414726 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01037046001 8411915 8414726 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01037046001 8411915 8414726 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01037046001 8411915 8414726 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01037046001 8411915 8414726 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01037046001 8411915 8414726 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01037046001 8411915 8414726 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01037046001 8411915 8414726 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01037046001 8411915 8414726 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01037046001 8411915 8414726 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01037046001 8411915 8414726 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01037046001 8411915 8414726 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01037046001 8411915 8414726 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01037046001 8411915 8414726 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01037046001 8411915 8414726 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01037046001 8411915 8414726 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01021069001 14152439 14154922 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01021069001 14152439 14154922 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01021069001 14152439 14154922 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01021069001 14152439 14154922 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031688001 20212999 20214065 GSVIVG01000854001 3058093 3058383 GSVIVG01025490001 368931 374770 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025490001 368931 374770 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025490001 368931 374770 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025490001 368931 374770 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022147001 16967002 16972327 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA GSVIVG01022147001 16967002 16972327 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GSVIVG01036757001 22939141 22943152 GSVIVG01011491001 30020537 30024558 GSVIVG01022150001 16986689 17004769 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA GSVIVG01022150001 16986689 17004769 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GSVIVG01001155001 1223757 1230175 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01001155001 1223757 1230175 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01010437001 20569149 20570248 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01010437001 20569149 20570248 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000402001 7549484 7550625 Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01000402001 7549484 7550625 Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01029137001 19270288 19280274 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01029137001 19270288 19280274 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01029137001 19270288 19280274 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01029137001 19270288 19280274 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01011602001 6048756 6061508 GO:0006541 glutamine metabolic process The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01011602001 6048756 6061508 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01011602001 6048756 6061508 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01011602001 6048756 6061508 GO:0006541 glutamine metabolic process The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid. IEA Catalysis of the reaction: chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate. IEA GO:0004049 anthranilate synthase activity GSVIVG01011602001 6048756 6061508 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate. IEA GO:0004049 anthranilate synthase activity GSVIVG01011602001 6048756 6061508 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate. IEA GO:0004049 anthranilate synthase activity GSVIVG01030508001 6310844 6312506 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01014994001 226131 262979 GSVIVG01035451001 1365801 1369920 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01035451001 1365801 1369920 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01035451001 1365801 1369920 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015935 small ribosomal subunit The smaller of the two subunits of a ribosome. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01035451001 1365801 1369920 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01035451001 1365801 1369920 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01035451001 1365801 1369920 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015935 small ribosomal subunit The smaller of the two subunits of a ribosome. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01027084001 18075817 18081554 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01027084001 18075817 18081554 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01027084001 18075817 18081554 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027084001 18075817 18081554 Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01033690001 18627007 18640522 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0000159 protein phosphatase type 2A complex A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit. IEA Modulation of the activity of the enzyme protein phosphatase type 2A. IEA GO:0008601 protein phosphatase type 2A regulator activity GSVIVG01033690001 18627007 18640522 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Modulation of the activity of the enzyme protein phosphatase type 2A. IEA GO:0008601 protein phosphatase type 2A regulator activity GSVIVG01033690001 18627007 18640522 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0000159 protein phosphatase type 2A complex A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit. IEA Modulation of the activity of the enzyme protein phosphatase type 2A. IEA GO:0008601 protein phosphatase type 2A regulator activity GSVIVG01033690001 18627007 18640522 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Modulation of the activity of the enzyme protein phosphatase type 2A. IEA GO:0008601 protein phosphatase type 2A regulator activity GSVIVG01028120001 3983621 3990173 GSVIVG01033089001 25641344 25646194 GSVIVG01011911001 3050000 3051482 GSVIVG01037432001 13833678 13857982 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01037432001 13833678 13857982 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01037432001 13833678 13857982 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01037432001 13833678 13857982 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029641001 20283495 20284280 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01007132001 30305189 30308045 GSVIVG01026960001 19015234 19019496 GSVIVG01002523001 35178073 35180798 GSVIVG01032108001 22605252 22605344 GSVIVG01022798001 16704244 16707373 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01022798001 16704244 16707373 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01022798001 16704244 16707373 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01014005001 8830495 8830740 GSVIVG01036224001 8739519 8740346 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01023924001 2456221 2457111 GSVIVG01014630001 7962057 7965054 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01010939001 2815925 2820853 GSVIVG01010354001 19730785 19737152 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01010354001 19730785 19737152 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and primer. IEA GO:0003887 DNA-directed DNA polymerase activity GSVIVG01010354001 19730785 19737152 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032861001 154343 155996 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01032861001 154343 155996 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01032861001 154343 155996 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01032861001 154343 155996 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01012834001 5932036 5943027 GSVIVG01008107001 5737662 5753594 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01008107001 5737662 5753594 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01036436001 5138938 5145604 GSVIVG01028378001 6831921 6838410 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01007243001 31055658 31060438 Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01007243001 31055658 31060438 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01007243001 31055658 31060438 Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01013215001 6675174 6677663 GSVIVG01021535001 6739758 6748051 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01009059001 4605340 4607035 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01014064001 38670 39146 GO:0006526 arginine biosynthetic process The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid. IEA Catalysis of the reaction: ATP + L-citrulline + L-aspartate = AMP + diphosphate + (N(omega)-L-arginino)succinate. IEA GO:0004055 argininosuccinate synthase activity GSVIVG01014064001 38670 39146 GO:0006526 arginine biosynthetic process The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010226001 17939355 17940260 GSVIVG01031260001 714256 726851 GO:0006606 protein import into nucleus The directed movement of a protein from the cytoplasm to the nucleus. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031260001 714256 726851 GO:0006606 protein import into nucleus The directed movement of a protein from the cytoplasm to the nucleus. IEA GO:0005643 nuclear pore Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031260001 714256 726851 GO:0006606 protein import into nucleus The directed movement of a protein from the cytoplasm to the nucleus. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031260001 714256 726851 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031260001 714256 726851 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005643 nuclear pore Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031260001 714256 726851 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031260001 714256 726851 GO:0006606 protein import into nucleus The directed movement of a protein from the cytoplasm to the nucleus. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01031260001 714256 726851 GO:0006606 protein import into nucleus The directed movement of a protein from the cytoplasm to the nucleus. IEA GO:0005643 nuclear pore Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01031260001 714256 726851 GO:0006606 protein import into nucleus The directed movement of a protein from the cytoplasm to the nucleus. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01031260001 714256 726851 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01031260001 714256 726851 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005643 nuclear pore Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01031260001 714256 726851 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01009147001 5505643 5516683 GO:0006094 gluconeogenesis The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. IEA Catalysis of the reaction: D-glucose 6-phosphate = D-fructose 6-phosphate. IEA GO:0004347 glucose-6-phosphate isomerase activity GSVIVG01009147001 5505643 5516683 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the reaction: D-glucose 6-phosphate = D-fructose 6-phosphate. IEA GO:0004347 glucose-6-phosphate isomerase activity GSVIVG01008026001 6553937 6556559 GSVIVG01029296001 17381540 17393388 GO:0046836 glycolipid transport The directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Enables the directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of, within or between cells. IEA GO:0017089 glycolipid transporter activity GSVIVG01029296001 17381540 17393388 GO:0046836 glycolipid transport The directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a glycolipid, any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic moiety such as an acylglycerol, a sphingoid, a ceramide (N-acylsphingoid) or a prenyl phosphate. IEA GO:0051861 glycolipid binding GSVIVG01020027001 11409315 11410477 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01037007001 8995955 9000573 GSVIVG01038491001 10318929 10319612 GSVIVG01020757001 2311491 2311850 GSVIVG01012838001 5959675 5963094 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01012838001 5959675 5963094 GO:0009247 glycolipid biosynthetic process The chemical reactions and pathways resulting in the formation of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide). IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01012838001 5959675 5963094 GO:0030259 lipid glycosylation Covalent attachment of a glycosyl residue to a lipid molecule. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01012838001 5959675 5963094 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01012838001 5959675 5963094 GO:0009247 glycolipid biosynthetic process The chemical reactions and pathways resulting in the formation of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide). IEA Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01012838001 5959675 5963094 GO:0030259 lipid glycosylation Covalent attachment of a glycosyl residue to a lipid molecule. IEA Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01019888001 4246953 4247870 GSVIVG01024350001 1295222 1303689 GO:0006094 gluconeogenesis The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. IEA Catalysis of the reaction: source of phosphate + oxaloacetate = phosphoenolpyruvate + CO2. IEA GO:0004611 phosphoenolpyruvate carboxykinase activity GSVIVG01024350001 1295222 1303689 GO:0006094 gluconeogenesis The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. IEA Catalysis of the reaction: ATP + oxaloacetate = ADP + phosphoenolpyruvate + CO2. IEA GO:0004612 phosphoenolpyruvate carboxykinase (ATP) activity GSVIVG01024350001 1295222 1303689 GO:0006094 gluconeogenesis The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024350001 1295222 1303689 GO:0006094 gluconeogenesis The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. IEA Interacting selectively and non-covalently with purine nucleotides, any compound consisting of a purine nucleoside esterified with (ortho)phosphate. IEA GO:0017076 purine nucleotide binding GSVIVG01014415001 3562145 3563502 GSVIVG01021647001 8686343 8689579 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01021647001 8686343 8689579 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01021647001 8686343 8689579 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01021647001 8686343 8689579 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01021647001 8686343 8689579 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011744001 4650632 4654857 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01011744001 4650632 4654857 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01011744001 4650632 4654857 GO:0008272 sulfate transport The directed movement of sulfate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01011744001 4650632 4654857 GO:0008272 sulfate transport The directed movement of sulfate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01011744001 4650632 4654857 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01011744001 4650632 4654857 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01011744001 4650632 4654857 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01011744001 4650632 4654857 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01011744001 4650632 4654857 GO:0008272 sulfate transport The directed movement of sulfate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01011744001 4650632 4654857 GO:0008272 sulfate transport The directed movement of sulfate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01011744001 4650632 4654857 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01011744001 4650632 4654857 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01008663001 39227 44383 GSVIVG01000761001 486615 497744 GO:0006014 D-ribose metabolic process The chemical reactions and pathways involving D-ribose (ribo-pentose). As beta-D-ribofuranose, D-ribose forms the glycose moiety of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12. IEA Catalysis of the reaction: ATP + D-ribose = ADP + D-ribose 5-phosphate. IEA GO:0004747 ribokinase activity GSVIVG01003340001 9167252 9171715 GSVIVG01037885001 6718592 6754398 GSVIVG01015496001 4223684 4225253 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01015496001 4223684 4225253 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01015496001 4223684 4225253 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01015496001 4223684 4225253 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023548001 9827964 9838584 GSVIVG01027926001 9520537 9521514 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01020073001 10769655 10781589 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01020073001 10769655 10781589 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01020073001 10769655 10781589 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01020073001 10769655 10781589 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018741001 20280810 20281115 GSVIVG01000286001 2263726 2264543 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01000286001 2263726 2264543 Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium. IEA GO:0005544 calcium-dependent phospholipid binding GSVIVG01003243001 8264456 8265541 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025814001 11561865 11579583 GSVIVG01013591001 21243777 21245925 GSVIVG01013426001 539606 545129 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01013426001 539606 545129 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01036639001 19538187 19542477 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01036639001 19538187 19542477 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01036639001 19538187 19542477 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01036639001 19538187 19542477 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036639001 19538187 19542477 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023152001 21903254 21909960 GO:0006306 DNA methylation The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01023152001 21903254 21909960 GO:0006306 DNA methylation The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. IEA Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing cytosine = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine. IEA GO:0003886 DNA (cytosine-5-)-methyltransferase activity GSVIVG01023152001 21903254 21909960 GO:0006306 DNA methylation The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01023152001 21903254 21909960 GO:0006306 DNA methylation The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01022212001 17531802 17539828 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01022212001 17531802 17539828 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01022212001 17531802 17539828 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01022212001 17531802 17539828 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01022212001 17531802 17539828 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035262001 11587680 11589305 GO:0006821 chloride transport The directed movement of chloride into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a chloride ion by a voltage-gated channel. IEA GO:0005247 voltage-gated chloride channel activity GSVIVG01015884001 18936110 18943597 GO:0006829 zinc ion transport The directed movement of zinc (Zn) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. IEA GO:0005385 zinc ion transmembrane transporter activity GSVIVG01015884001 18936110 18943597 GO:0006829 zinc ion transport The directed movement of zinc (Zn) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. IEA GO:0005385 zinc ion transmembrane transporter activity GSVIVG01015884001 18936110 18943597 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. IEA GO:0005385 zinc ion transmembrane transporter activity GSVIVG01015884001 18936110 18943597 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. IEA GO:0005385 zinc ion transmembrane transporter activity GSVIVG01015884001 18936110 18943597 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. IEA GO:0005385 zinc ion transmembrane transporter activity GSVIVG01015884001 18936110 18943597 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. IEA GO:0005385 zinc ion transmembrane transporter activity GSVIVG01015884001 18936110 18943597 GO:0006829 zinc ion transport The directed movement of zinc (Zn) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01015884001 18936110 18943597 GO:0006829 zinc ion transport The directed movement of zinc (Zn) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01015884001 18936110 18943597 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01015884001 18936110 18943597 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01015884001 18936110 18943597 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01015884001 18936110 18943597 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01028836001 18255109 18256261 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with a mating-type factor pheromone to initiate a change in cell activity. IEA GO:0004932 mating-type factor pheromone receptor activity GSVIVG01002511001 35140627 35141617 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01002511001 35140627 35141617 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01002511001 35140627 35141617 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01002511001 35140627 35141617 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01004007001 14269421 14270959 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01003594001 11076960 11079625 GSVIVG01003139001 7573855 7576336 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01003139001 7573855 7576336 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01013199001 6818093 6834743 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013199001 6818093 6834743 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030132 clathrin coat of coated pit The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013199001 6818093 6834743 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013199001 6818093 6834743 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030132 clathrin coat of coated pit The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013199001 6818093 6834743 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013199001 6818093 6834743 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030132 clathrin coat of coated pit The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000077001 3270308 3274319 GSVIVG01021344001 4275827 4277916 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01021344001 4275827 4277916 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021101001 1460047 1464478 GSVIVG01018700001 10964397 10968772 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01018700001 10964397 10968772 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01030291001 9389605 9419691 GO:0006826 iron ion transport The directed movement of iron (Fe) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01030291001 9389605 9419691 GO:0006879 cellular iron ion homeostasis Any process involved in the maintenance of an internal steady-state of iron ions at the level of a cell. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01030291001 9389605 9419691 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01030291001 9389605 9419691 GO:0006826 iron ion transport The directed movement of iron (Fe) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with ferric iron, Fe(III). IEA GO:0008199 ferric iron binding GSVIVG01030291001 9389605 9419691 GO:0006879 cellular iron ion homeostasis Any process involved in the maintenance of an internal steady-state of iron ions at the level of a cell. IEA Interacting selectively and non-covalently with ferric iron, Fe(III). IEA GO:0008199 ferric iron binding GSVIVG01030291001 9389605 9419691 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with ferric iron, Fe(III). IEA GO:0008199 ferric iron binding GSVIVG01030291001 9389605 9419691 GO:0006826 iron ion transport The directed movement of iron (Fe) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01030291001 9389605 9419691 GO:0006879 cellular iron ion homeostasis Any process involved in the maintenance of an internal steady-state of iron ions at the level of a cell. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01030291001 9389605 9419691 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01030291001 9389605 9419691 GO:0006826 iron ion transport The directed movement of iron (Fe) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01030291001 9389605 9419691 GO:0006879 cellular iron ion homeostasis Any process involved in the maintenance of an internal steady-state of iron ions at the level of a cell. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01030291001 9389605 9419691 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01023100001 22604092 22605027 GSVIVG01007403001 31651832 31654925 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GSVIVG01001855001 24864 46950 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01001855001 24864 46950 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0008236 serine-type peptidase activity GSVIVG01035364001 781102 787349 GSVIVG01032933001 24260902 24295647 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01032933001 24260902 24295647 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01001827001 26130486 26133065 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01034626001 13756065 13775901 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GSVIVG01034913001 83803 84482 GSVIVG01034476001 20720304 20720676 GSVIVG01024235001 102222 103573 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01024235001 102222 103573 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01024235001 102222 103573 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01024235001 102222 103573 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01024235001 102222 103573 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01024235001 102222 103573 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01024235001 102222 103573 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01024235001 102222 103573 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01024235001 102222 103573 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01024235001 102222 103573 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01024235001 102222 103573 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01024235001 102222 103573 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01024235001 102222 103573 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01024235001 102222 103573 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01024235001 102222 103573 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01024235001 102222 103573 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01013464001 233636 236329 GSVIVG01002276001 33923431 33924629 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01002276001 33923431 33924629 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025050001 5004658 5010625 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01025050001 5004658 5010625 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01008909001 3320931 3328582 GSVIVG01035348001 676239 680999 GO:0006544 glycine metabolic process The chemical reactions and pathways involving glycine, aminoethanoic acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035348001 676239 680999 GO:0006563 L-serine metabolic process The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035348001 676239 680999 GO:0006544 glycine metabolic process The chemical reactions and pathways involving glycine, aminoethanoic acid. IEA Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine. IEA GO:0004372 glycine hydroxymethyltransferase activity GSVIVG01035348001 676239 680999 GO:0006563 L-serine metabolic process The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. IEA Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine. IEA GO:0004372 glycine hydroxymethyltransferase activity GSVIVG01035348001 676239 680999 GO:0006544 glycine metabolic process The chemical reactions and pathways involving glycine, aminoethanoic acid. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01035348001 676239 680999 GO:0006563 L-serine metabolic process The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01028462001 7947952 7952882 GO:0006760 folic acid and derivative metabolic process The chemical reactions and pathways involving folic acid and its derivatives. IEA Catalysis of the reaction: 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine = 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde. IEA GO:0004150 dihydroneopterin aldolase activity GSVIVG01010108001 15654692 15658282 Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01033486001 20328149 20328910 GSVIVG01029458001 22633172 22640751 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with lysosphingolipid or lysophosphatidic acid to initiate a change in cell activity. IEA GO:0001619 lysosphingolipid and lysophosphatidic acid receptor activity GSVIVG01029458001 22633172 22640751 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with lysosphingolipid or lysophosphatidic acid to initiate a change in cell activity. IEA GO:0001619 lysosphingolipid and lysophosphatidic acid receptor activity GSVIVG01029458001 22633172 22640751 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01029458001 22633172 22640751 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025184001 3607585 3614048 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. IEA GO:0016853 isomerase activity GSVIVG01014096001 352673 354668 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014096001 352673 354668 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01015803001 17636596 17637951 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015803001 17636596 17637951 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01015803001 17636596 17637951 Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01016952001 2908971 2912134 GSVIVG01012305001 13234256 13240327 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012305001 13234256 13240327 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01009916001 12343092 12350591 GSVIVG01038571001 21779447 21784699 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01036678001 24013271 24013696 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01036678001 24013271 24013696 Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01011659001 5486107 5493034 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01011659001 5486107 5493034 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01011096001 1630660 1634375 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01011096001 1630660 1634375 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01008219001 4523012 4527218 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01000843001 2829364 2838217 GSVIVG01034519001 19959477 20018606 GSVIVG01011266001 10254228 10255732 GSVIVG01034890001 16025495 16053846 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. IEA GO:0004725 protein tyrosine phosphatase activity GSVIVG01034890001 16025495 16053846 GO:0016311 dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. IEA Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. IEA GO:0004725 protein tyrosine phosphatase activity GSVIVG01034890001 16025495 16053846 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. IEA GO:0016791 phosphatase activity GSVIVG01034890001 16025495 16053846 GO:0016311 dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. IEA Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. IEA GO:0016791 phosphatase activity GSVIVG01004001001 14194385 14221077 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01004001001 14194385 14221077 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01004001001 14194385 14221077 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01008550001 942499 942936 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008550001 942499 942936 Interacting selectively and non-covalently with thiamin pyrophosphate, the diphosphoric ester of thiamin. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases. IEA GO:0030976 thiamin pyrophosphate binding GSVIVG01033067001 25509955 25536232 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01033067001 25509955 25536232 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01028445001 7654374 7719841 GSVIVG01037367001 14920068 14922063 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01020528001 4766938 4820598 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01020528001 4766938 4820598 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01010975001 2497398 2509996 GSVIVG01034723001 8447681 8461410 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01034723001 8447681 8461410 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034723001 8447681 8461410 Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01029038001 11135153 11141461 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01029038001 11135153 11141461 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01029038001 11135153 11141461 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01029038001 11135153 11141461 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029038001 11135153 11141461 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01002268001 33789881 33790721 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01002268001 33789881 33790721 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01016537001 3002901 3015758 GSVIVG01009794001 11297038 11299865 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GSVIVG01015113001 1126404 1129696 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01038200001 24298325 24300287 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01029145001 19234832 19236560 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01024344001 1224225 1231904 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain The V1 domain of a proton-transporting V-type ATPase found in the vacuolar membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024344001 1224225 1231904 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain The V1 domain of a proton-transporting V-type ATPase found in the vacuolar membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01024344001 1224225 1231904 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain The V1 domain of a proton-transporting V-type ATPase found in the vacuolar membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01015789001 17464312 17465298 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01010790001 22616261 22620249 GSVIVG01009177001 5765989 5795580 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01003274001 8651584 8651743 GSVIVG01025063001 4826645 4827497 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025063001 4826645 4827497 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025063001 4826645 4827497 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025063001 4826645 4827497 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025063001 4826645 4827497 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA IEA GO:0016986 transcription initiation factor activity GSVIVG01025063001 4826645 4827497 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA IEA GO:0016986 transcription initiation factor activity GSVIVG01025063001 4826645 4827497 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA IEA GO:0016986 transcription initiation factor activity GSVIVG01025063001 4826645 4827497 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA IEA GO:0016986 transcription initiation factor activity GSVIVG01004324001 38105191 38108321 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GSVIVG01017881001 4266468 4282546 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01017881001 4266468 4282546 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01027376001 15529974 15531978 GSVIVG01032709001 1343258 1345916 GSVIVG01032216001 13072169 13073930 GSVIVG01027610001 15062588 15072435 GO:0006303 double-strand break repair via nonhomologous end joining The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01027610001 15062588 15072435 GO:0006303 double-strand break repair via nonhomologous end joining The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate, driving the unwinding of the DNA helix. IEA GO:0004003 ATP-dependent DNA helicase activity GSVIVG01027610001 15062588 15072435 GO:0006303 double-strand break repair via nonhomologous end joining The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01030263001 9745143 9747339 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01013699001 2785186 2790236 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01013699001 2785186 2790236 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01013699001 2785186 2790236 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01001612001 18456154 18457526 GSVIVG01000986001 11148423 11149515 GSVIVG01015313001 2582031 2599309 GSVIVG01012873001 6397984 6398548 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012873001 6397984 6398548 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01012873001 6397984 6398548 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01035068001 1282252 1288085 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GSVIVG01035068001 1282252 1288085 GO:0009607 response to biotic stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism. IEA GSVIVG01008562001 851143 859908 GSVIVG01031696001 20273518 20276507 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin. IEA GO:0004221 ubiquitin thiolesterase activity GSVIVG01038642001 21257361 21269242 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01038642001 21257361 21269242 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01038642001 21257361 21269242 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01038642001 21257361 21269242 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01038275001 24884117 24891399 GSVIVG01026499001 22563528 22600751 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01026499001 22563528 22600751 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026499001 22563528 22600751 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026499001 22563528 22600751 Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01026499001 22563528 22600751 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01025257001 2647914 2652455 GSVIVG01008870001 2921245 2922590 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01029025001 10894992 10900932 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029025001 10894992 10900932 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029025001 10894992 10900932 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029025001 10894992 10900932 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019543001 1473462 1474469 GSVIVG01020555001 4433565 4433999 GSVIVG01012407001 518802 521476 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01012407001 518802 521476 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01012407001 518802 521476 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012407001 518802 521476 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012407001 518802 521476 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012407001 518802 521476 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012407001 518802 521476 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01012407001 518802 521476 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01028147001 4200160 4202241 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01028147001 4200160 4202241 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01015502001 4267139 4272990 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a reaction that alters the configuration of one or more chiral centers in an amino acid. IEA GO:0016855 racemase and epimerase activity, acting on amino acids and derivatives GSVIVG01023394001 12695793 12700387 GSVIVG01020846001 1123954 1126191 GSVIVG01020543001 4643379 4650715 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01020543001 4643379 4650715 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01020543001 4643379 4650715 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01020543001 4643379 4650715 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the transfer of a nucleotidyl group to a reactant. IEA GO:0016779 nucleotidyltransferase activity GSVIVG01020543001 4643379 4650715 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with a ribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to ribose. IEA GO:0032549 ribonucleoside binding GSVIVG01009206001 6235027 6247312 GO:0006464 protein modification process The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. IEA GO:0016881 acid-amino acid ligase activity GSVIVG01009206001 6235027 6247312 GO:0019941 modification-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. IEA GO:0016881 acid-amino acid ligase activity GSVIVG01015293001 2454950 2455378 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01015293001 2454950 2455378 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01015293001 2454950 2455378 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01015293001 2454950 2455378 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01006101001 41493645 41495878 GSVIVG01011147001 7302980 7303309 GSVIVG01022467001 3378128 3385686 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01022467001 3378128 3385686 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01028265001 5031265 5032609 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the reaction: pectin + n H2O = n methanol + pectate. IEA GO:0030599 pectinesterase activity GSVIVG01014461001 4088499 4092360 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin. IEA GO:0004221 ubiquitin thiolesterase activity GSVIVG01025284001 2443493 2443835 GSVIVG01019126001 16483825 16487265 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01006481001 26390515 26391856 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01006481001 26390515 26391856 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01006481001 26390515 26391856 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01006481001 26390515 26391856 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01022351001 18872134 18874238 GSVIVG01022030001 4098504 4102631 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01022030001 4098504 4102631 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01022030001 4098504 4102631 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01022030001 4098504 4102631 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01001412001 18840211 18858436 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001412001 18840211 18858436 Catalysis of the elimination of H2S or substituted H2S. IEA GO:0016846 carbon-sulfur lyase activity GSVIVG01001412001 18840211 18858436 Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01014192001 1367750 1370643 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01014192001 1367750 1370643 Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01007182001 30672402 30686906 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01007182001 30672402 30686906 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01006969001 29476387 29479315 GSVIVG01001434001 20952915 20953742 GSVIVG01015971001 16508396 16516615 GSVIVG01020430001 19553944 19559065 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01020430001 19553944 19559065 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017750001 3139279 3139844 GSVIVG01036192001 9257252 9263811 GSVIVG01032019001 23475916 23482955 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032019001 23475916 23482955 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01032019001 23475916 23482955 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01036001001 7004530 7007066 GSVIVG01025676001 13018070 13020594 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025676001 13018070 13020594 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01025676001 13018070 13020594 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01025676001 13018070 13020594 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01025676001 13018070 13020594 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020209001 8992774 9017978 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01020209001 8992774 9017978 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01020209001 8992774 9017978 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01020209001 8992774 9017978 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0044431 Golgi apparatus part Any constituent part of the Golgi apparatus, a compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01020209001 8992774 9017978 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01020209001 8992774 9017978 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01020209001 8992774 9017978 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01020209001 8992774 9017978 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0044431 Golgi apparatus part Any constituent part of the Golgi apparatus, a compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01020209001 8992774 9017978 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01020209001 8992774 9017978 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01020209001 8992774 9017978 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01020209001 8992774 9017978 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0044431 Golgi apparatus part Any constituent part of the Golgi apparatus, a compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01020209001 8992774 9017978 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020209001 8992774 9017978 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020209001 8992774 9017978 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020209001 8992774 9017978 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0044431 Golgi apparatus part Any constituent part of the Golgi apparatus, a compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020209001 8992774 9017978 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020209001 8992774 9017978 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020209001 8992774 9017978 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020209001 8992774 9017978 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0044431 Golgi apparatus part Any constituent part of the Golgi apparatus, a compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020209001 8992774 9017978 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020209001 8992774 9017978 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020209001 8992774 9017978 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020209001 8992774 9017978 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0044431 Golgi apparatus part Any constituent part of the Golgi apparatus, a compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020209001 8992774 9017978 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01020209001 8992774 9017978 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01020209001 8992774 9017978 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01020209001 8992774 9017978 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0044431 Golgi apparatus part Any constituent part of the Golgi apparatus, a compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01020209001 8992774 9017978 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01020209001 8992774 9017978 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01020209001 8992774 9017978 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01020209001 8992774 9017978 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0044431 Golgi apparatus part Any constituent part of the Golgi apparatus, a compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01020209001 8992774 9017978 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01020209001 8992774 9017978 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01020209001 8992774 9017978 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01020209001 8992774 9017978 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0044431 Golgi apparatus part Any constituent part of the Golgi apparatus, a compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01017986001 5291971 5292289 GSVIVG01025073001 4771784 4775849 GSVIVG01008284001 3660239 3661508 GSVIVG01016647001 34810 53863 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01036782001 22654525 22657736 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01009365001 7798157 7812824 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0005669 transcription factor TFIID complex A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01009365001 7798157 7812824 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0005669 transcription factor TFIID complex A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters. IEA IEA GO:0016986 transcription initiation factor activity GSVIVG01026248001 14814132 14815755 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01026248001 14814132 14815755 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01025945001 26888677 26896544 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025945001 26888677 26896544 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025945001 26888677 26896544 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025945001 26888677 26896544 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01025945001 26888677 26896544 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01025945001 26888677 26896544 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01025945001 26888677 26896544 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01025945001 26888677 26896544 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01025945001 26888677 26896544 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01014297001 2416077 2441445 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014297001 2416077 2441445 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014297001 2416077 2441445 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014297001 2416077 2441445 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009194001 5963491 6027423 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01012736001 1111243 1118628 GSVIVG01027818001 8137444 8138375 GSVIVG01034550001 19583451 19584514 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA GSVIVG01031352001 125134 128371 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01031352001 125134 128371 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01031352001 125134 128371 GO:0006424 glutamyl-tRNA aminoacylation The process of coupling glutamate to glutamyl-tRNA, catalyzed by glutamyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'- adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01031352001 125134 128371 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01031352001 125134 128371 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01031352001 125134 128371 GO:0006424 glutamyl-tRNA aminoacylation The process of coupling glutamate to glutamyl-tRNA, catalyzed by glutamyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'- adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01031352001 125134 128371 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu). IEA GO:0004818 glutamate-tRNA ligase activity GSVIVG01031352001 125134 128371 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu). IEA GO:0004818 glutamate-tRNA ligase activity GSVIVG01031352001 125134 128371 GO:0006424 glutamyl-tRNA aminoacylation The process of coupling glutamate to glutamyl-tRNA, catalyzed by glutamyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'- adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu). IEA GO:0004818 glutamate-tRNA ligase activity GSVIVG01031352001 125134 128371 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031352001 125134 128371 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031352001 125134 128371 GO:0006424 glutamyl-tRNA aminoacylation The process of coupling glutamate to glutamyl-tRNA, catalyzed by glutamyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'- adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031352001 125134 128371 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01031352001 125134 128371 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01031352001 125134 128371 GO:0006424 glutamyl-tRNA aminoacylation The process of coupling glutamate to glutamyl-tRNA, catalyzed by glutamyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'- adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01026481001 22916097 22917542 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01022910001 18138655 18139707 GSVIVG01029036001 11066380 11068652 GSVIVG01023145001 22011079 22025594 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01027496001 16209883 16213665 GSVIVG01023219001 20984928 20988981 GSVIVG01001232001 1683559 1685033 GSVIVG01028264001 5026786 5031256 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the reaction: pectin + n H2O = n methanol + pectate. IEA GO:0030599 pectinesterase activity GSVIVG01013096001 8337781 8347539 GSVIVG01015767001 17161781 17168980 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01015767001 17161781 17168980 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015767001 17161781 17168980 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01015767001 17161781 17168980 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01008064001 6144991 6148040 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01025793001 11790799 11794362 GO:0006904 vesicle docking involved in exocytosis The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis. IEA GO:0000145 exocyst A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals. IEA GSVIVG01019718001 2719891 2720712 GSVIVG01035412001 1099194 1103857 GSVIVG01011524001 13170203 13171363 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01009127001 5323893 5336005 GSVIVG01028384001 6891622 6892722 GSVIVG01037347001 15369788 15370516 GSVIVG01032074001 22966517 22972607 GSVIVG01018593001 12605137 12605598 Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01018593001 12605137 12605598 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018593001 12605137 12605598 Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01018593001 12605137 12605598 Interacting selectively and non-covalently with thiamin pyrophosphate, the diphosphoric ester of thiamin. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases. IEA GO:0030976 thiamin pyrophosphate binding GSVIVG01001057001 7136052 7138529 GSVIVG01016504001 3332382 3333610 GSVIVG01020046001 11205576 11207549 GSVIVG01022428001 20106909 20109677 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01018202001 13267508 13270677 GSVIVG01034753001 9014696 9023613 GSVIVG01035936001 6129271 6138162 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01035936001 6129271 6138162 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031895001 5229382 5231737 GSVIVG01017701001 2775453 2778471 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005764 lysosome A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01017701001 2775453 2778471 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA GO:0005764 lysosome A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01017701001 2775453 2778471 GO:0006665 sphingolipid metabolic process The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). IEA GO:0005764 lysosome A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01009183001 5851680 5855061 GSVIVG01016996001 3279297 3283962 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01016996001 3279297 3283962 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01016996001 3279297 3283962 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01010038001 13719617 13730593 GO:0006904 vesicle docking involved in exocytosis The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis. IEA GSVIVG01010038001 13719617 13730593 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GSVIVG01000936001 22058282 22060336 GSVIVG01021473001 5939677 5946651 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021473001 5939677 5946651 Catalysis of the transfer of a functional group from one position to another within a single molecule. IEA GO:0016866 intramolecular transferase activity GSVIVG01038357001 13480805 13500359 GSVIVG01035439001 1266807 1275745 GSVIVG01034014001 15866873 15886188 GSVIVG01015236001 2016637 2022471 GO:0006479 protein amino acid methylation The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a methyl group (CH3-) to a protein. IEA GO:0008276 protein methyltransferase activity GSVIVG01008155001 5244356 5248671 GSVIVG01009678001 10381791 10384308 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01009678001 10381791 10384308 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01009678001 10381791 10384308 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01009678001 10381791 10384308 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01024827001 6579953 6580612 GSVIVG01014186001 1328456 1335388 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GSVIVG01007681001 10494464 10498141 GSVIVG01017181001 5075735 5077332 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01032533001 28147213 28149942 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion. IEA GO:0004806 triglyceride lipase activity GSVIVG01027020001 18525141 18535167 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GSVIVG01028173001 4403256 4412590 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01013334001 12269554 12270388 GSVIVG01000174001 15867223 15875213 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000174001 15867223 15875213 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01035282001 11913809 11938251 GSVIVG01033767001 17999543 18003438 GSVIVG01021949001 5248914 5251742 GO:0006801 superoxide metabolic process The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01021949001 5248914 5251742 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01025062001 4827900 4834236 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025062001 4827900 4834236 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025062001 4827900 4834236 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025062001 4827900 4834236 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025062001 4827900 4834236 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025062001 4827900 4834236 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025062001 4827900 4834236 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025062001 4827900 4834236 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025062001 4827900 4834236 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01025062001 4827900 4834236 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01025062001 4827900 4834236 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01025062001 4827900 4834236 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01025062001 4827900 4834236 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01025062001 4827900 4834236 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01025062001 4827900 4834236 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01025062001 4827900 4834236 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01025062001 4827900 4834236 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025062001 4827900 4834236 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025062001 4827900 4834236 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025062001 4827900 4834236 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025062001 4827900 4834236 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025062001 4827900 4834236 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025062001 4827900 4834236 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025062001 4827900 4834236 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025062001 4827900 4834236 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01025062001 4827900 4834236 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01025062001 4827900 4834236 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01025062001 4827900 4834236 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01025062001 4827900 4834236 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01025062001 4827900 4834236 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01025062001 4827900 4834236 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01025062001 4827900 4834236 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01025062001 4827900 4834236 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01025062001 4827900 4834236 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01025062001 4827900 4834236 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01025062001 4827900 4834236 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01025062001 4827900 4834236 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01025062001 4827900 4834236 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01025062001 4827900 4834236 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01025062001 4827900 4834236 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01020426001 19618651 19619493 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031224001 1059334 1062835 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01031224001 1059334 1062835 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01008312001 3359778 3359966 GSVIVG01003559001 14647046 14647090 GSVIVG01004962001 17104708 17105333 GSVIVG01000405001 7562774 7563172 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01000405001 7562774 7563172 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01025927001 27159126 27159396 GSVIVG01015321001 2664769 2667229 GO:0000398 nuclear mRNA splicing, via spliceosome The joining together of exons from one or more primary transcripts of nuclear messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. IEA GO:0005681 spliceosomal complex Any of a series of ribonucleoprotein complexes that contain RNA and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the splicing of a messenger RNA primary transcript to excise an intron. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000832001 2677096 2680628 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017399001 7943093 7957417 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01028338001 6276299 6277707 Functions in the storage of nutritious substrates. IEA GO:0045735 nutrient reservoir activity GSVIVG01028864001 18017015 18018914 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01028864001 18017015 18018914 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01028864001 18017015 18018914 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01028864001 18017015 18018914 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01030946001 19590275 19590647 GSVIVG01026800001 7436536 7460432 GSVIVG01012357001 1242517 1244120 GSVIVG01035618001 2749901 2752003 GSVIVG01009571001 9514594 9516841 GO:0000226 microtubule cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. IEA GO:0000922 spindle pole Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules. IEA GSVIVG01009571001 9514594 9516841 GO:0000226 microtubule cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. IEA GO:0005815 microtubule organizing center A cytoplasmic structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides. IEA GSVIVG01026728001 5685390 5688083 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026728001 5685390 5688083 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028135001 4072814 4078927 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01028135001 4072814 4078927 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01028135001 4072814 4078927 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01028135001 4072814 4078927 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01028135001 4072814 4078927 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025001001 5375661 5385286 GSVIVG01017893001 4446641 4450992 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. IEA GO:0004725 protein tyrosine phosphatase activity GSVIVG01017893001 4446641 4450992 GO:0016311 dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. IEA Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. IEA GO:0004725 protein tyrosine phosphatase activity GSVIVG01017893001 4446641 4450992 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA Catalysis of the reaction: protein serine/threonine/tyrosine phosphate + H2O = protein serine/threonine/tyrosine + phosphate. IEA GO:0008138 protein tyrosine/serine/threonine phosphatase activity GSVIVG01017893001 4446641 4450992 GO:0016311 dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. IEA Catalysis of the reaction: protein serine/threonine/tyrosine phosphate + H2O = protein serine/threonine/tyrosine + phosphate. IEA GO:0008138 protein tyrosine/serine/threonine phosphatase activity GSVIVG01017893001 4446641 4450992 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. IEA GO:0016791 phosphatase activity GSVIVG01017893001 4446641 4450992 GO:0016311 dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. IEA Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. IEA GO:0016791 phosphatase activity GSVIVG01017893001 4446641 4450992 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA Catalysis of the reaction: MAP kinase serine/threonine/tyrosine phosphate + H2O = MAP kinase serine/threonine/tyrosine + phosphate. IEA GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity GSVIVG01017893001 4446641 4450992 GO:0016311 dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. IEA Catalysis of the reaction: MAP kinase serine/threonine/tyrosine phosphate + H2O = MAP kinase serine/threonine/tyrosine + phosphate. IEA GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity GSVIVG01034279001 14024096 14026593 GSVIVG01022593001 5679485 5680925 GSVIVG01009579001 9597349 9601051 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01001513001 5425428 5426127 GSVIVG01009440001 8368864 8373082 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004197 cysteine-type endopeptidase activity GSVIVG01009440001 8368864 8373082 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01008740001 1602591 1612334 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005665 DNA-directed RNA polymerase II, core complex RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01008740001 1602591 1612334 GO:0006366 transcription from RNA polymerase II promoter The synthesis of RNA from a DNA template by RNA polymerase II (Pol II), originating at a Pol II-specific promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs). IEA GO:0005665 DNA-directed RNA polymerase II, core complex RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01008740001 1602591 1612334 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005665 DNA-directed RNA polymerase II, core complex RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01008740001 1602591 1612334 GO:0006366 transcription from RNA polymerase II promoter The synthesis of RNA from a DNA template by RNA polymerase II (Pol II), originating at a Pol II-specific promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs). IEA GO:0005665 DNA-directed RNA polymerase II, core complex RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01003322001 9036286 9040263 GSVIVG01023024001 16756990 16760841 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate. IEA GO:0003774 motor activity GSVIVG01023024001 16756990 16760841 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016459 myosin complex A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. IEA Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate. IEA GO:0003774 motor activity GSVIVG01023024001 16756990 16760841 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with a thromboxane (TXA) to initiate a change in cell activity. IEA GO:0004960 thromboxane receptor activity GSVIVG01023024001 16756990 16760841 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016459 myosin complex A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. IEA Combining with a thromboxane (TXA) to initiate a change in cell activity. IEA GO:0004960 thromboxane receptor activity GSVIVG01023024001 16756990 16760841 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023024001 16756990 16760841 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016459 myosin complex A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009305001 7156540 7166217 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01009305001 7156540 7166217 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013598001 1128504 1129146 GSVIVG01025781001 11925225 11928422 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01010327001 19533132 19534966 GSVIVG01023121001 22348465 22357826 GSVIVG01018041001 5751269 5752716 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01018041001 5751269 5752716 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01030773001 15727414 15732065 GSVIVG01022735001 15809499 15810179 GSVIVG01031590001 18570162 18570552 GSVIVG01013769001 7756584 7759818 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01013769001 7756584 7759818 GO:0009234 menaquinone biosynthetic process The chemical reactions and pathways resulting in the formation of any of the menaquinones, any of the quinone-derived compounds synthesized by intestinal bacteria. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones have vitamin K activity and are known as vitamin K2. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01013769001 7756584 7759818 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: O-succinylbenzoyl-CoA = 1,4-dihydroxy-2-naphthoate + CoA. IEA GO:0008935 naphthoate synthase activity GSVIVG01013769001 7756584 7759818 GO:0009234 menaquinone biosynthetic process The chemical reactions and pathways resulting in the formation of any of the menaquinones, any of the quinone-derived compounds synthesized by intestinal bacteria. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones have vitamin K activity and are known as vitamin K2. IEA Catalysis of the reaction: O-succinylbenzoyl-CoA = 1,4-dihydroxy-2-naphthoate + CoA. IEA GO:0008935 naphthoate synthase activity GSVIVG01030185001 10733773 10737697 GSVIVG01031381001 19330192 19331287 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01032746001 1072521 1084172 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01032746001 1072521 1084172 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01032746001 1072521 1084172 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01032746001 1072521 1084172 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01032746001 1072521 1084172 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032746001 1072521 1084172 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01034376001 17173141 17222920 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01034376001 17173141 17222920 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034376001 17173141 17222920 Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01034376001 17173141 17222920 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01025557001 14068932 14069292 GSVIVG01034586001 19067283 19068738 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01034586001 19067283 19068738 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). IEA GO:0016769 transferase activity, transferring nitrogenous groups GSVIVG01034586001 19067283 19068738 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01012527001 660350 660673 GSVIVG01008512001 1241792 1242459 GSVIVG01007560001 12030876 12098518 GO:0006075 1,3-beta-glucan biosynthetic process The chemical reactions and pathways resulting in the formation of beta-1,3 glucans, compounds composed of glucose residues linked by 1,3-beta-D-glucosidic bonds. IEA GO:0000148 1,3-beta-glucan synthase complex A protein complex that catalyzes the transfer of a glucose moiety from UDP-glucose to a 1,3-beta-D-glucan chain. IEA Catalysis of the reaction: UDP-glucose + 1,3-beta-D-glucosyl(n) = UDP + 1,3-beta-D-glucosyl(n+1). IEA GO:0003843 1,3-beta-glucan synthase activity GSVIVG01007560001 12030876 12098518 GO:0006075 1,3-beta-glucan biosynthetic process The chemical reactions and pathways resulting in the formation of beta-1,3 glucans, compounds composed of glucose residues linked by 1,3-beta-D-glucosidic bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: UDP-glucose + 1,3-beta-D-glucosyl(n) = UDP + 1,3-beta-D-glucosyl(n+1). IEA GO:0003843 1,3-beta-glucan synthase activity GSVIVG01038138001 23782695 23787924 GSVIVG01036870001 18420866 18426824 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01036870001 18420866 18426824 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01024650001 8025147 8035002 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01011583001 6264420 6272529 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01023726001 10202862 10205188 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01023726001 10202862 10205188 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01020872001 753639 753809 GSVIVG01037342001 15442732 15450776 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01037342001 15442732 15450776 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01010186001 16963233 16970228 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases in DNA that result from the deamination of cytosine or the misincorporation of dUTP opposite an adenine. IEA GO:0004844 uracil DNA N-glycosylase activity GSVIVG01010186001 16963233 16970228 GO:0006284 base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. IEA Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases in DNA that result from the deamination of cytosine or the misincorporation of dUTP opposite an adenine. IEA GO:0004844 uracil DNA N-glycosylase activity GSVIVG01010186001 16963233 16970228 GO:0006974 response to DNA damage stimulus A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. IEA Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases in DNA that result from the deamination of cytosine or the misincorporation of dUTP opposite an adenine. IEA GO:0004844 uracil DNA N-glycosylase activity GSVIVG01010186001 16963233 16970228 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases in DNA that result from the deamination of cytosine or the misincorporation of dUTP opposite an adenine. IEA GO:0004844 uracil DNA N-glycosylase activity GSVIVG01010186001 16963233 16970228 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01010186001 16963233 16970228 GO:0006284 base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01010186001 16963233 16970228 GO:0006974 response to DNA damage stimulus A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01010186001 16963233 16970228 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01010186001 16963233 16970228 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01010186001 16963233 16970228 GO:0006284 base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01010186001 16963233 16970228 GO:0006974 response to DNA damage stimulus A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01010186001 16963233 16970228 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01010186001 16963233 16970228 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the hydrolysis of any N-glycosyl bond. IEA GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds GSVIVG01010186001 16963233 16970228 GO:0006284 base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. IEA Catalysis of the hydrolysis of any N-glycosyl bond. IEA GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds GSVIVG01010186001 16963233 16970228 GO:0006974 response to DNA damage stimulus A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. IEA Catalysis of the hydrolysis of any N-glycosyl bond. IEA GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds GSVIVG01010186001 16963233 16970228 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of any N-glycosyl bond. IEA GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds GSVIVG01018721001 10551996 10598240 GSVIVG01012723001 977723 999238 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: ADP-glucose + (1,4)-alpha-D-glucosyl(n) = ADP + (1,4)-alpha-D-glucosyl(n+1). IEA GO:0009011 starch synthase activity GSVIVG01012723001 977723 999238 GO:0009250 glucan biosynthetic process The chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues. IEA Catalysis of the reaction: ADP-glucose + (1,4)-alpha-D-glucosyl(n) = ADP + (1,4)-alpha-D-glucosyl(n+1). IEA GO:0009011 starch synthase activity GSVIVG01036740001 23132272 23133626 GSVIVG01036982001 9286348 9295982 GSVIVG01024538001 9054671 9071149 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01024538001 9054671 9071149 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01024538001 9054671 9071149 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01024538001 9054671 9071149 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01024538001 9054671 9071149 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033955001 16340008 16351151 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GSVIVG01026415001 23794825 23796668 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01026415001 23794825 23796668 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01028991001 10295157 10296788 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01028991001 10295157 10296788 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01028991001 10295157 10296788 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01028991001 10295157 10296788 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01007246001 31106526 31107398 GSVIVG01038146001 23880484 23883402 GSVIVG01028842001 18150126 18152952 GSVIVG01013840001 5109843 5112230 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028479001 8142303 8150598 GSVIVG01012188001 701419 707690 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01007696001 10300515 10303111 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007696001 10300515 10303111 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007696001 10300515 10303111 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01007696001 10300515 10303111 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01007696001 10300515 10303111 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01007696001 10300515 10303111 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01007696001 10300515 10303111 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01007696001 10300515 10303111 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01036241001 8234874 8240083 GSVIVG01032923001 24206933 24215532 GSVIVG01014920001 11909781 11912556 GSVIVG01011376001 29136473 29145598 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01011376001 29136473 29145598 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01011376001 29136473 29145598 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01011376001 29136473 29145598 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030215001 10357401 10373424 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005764 lysosome A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01030215001 10357401 10373424 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA GO:0005764 lysosome A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01030215001 10357401 10373424 GO:0006665 sphingolipid metabolic process The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). IEA GO:0005764 lysosome A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01012536001 896341 941202 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor. IEA GO:0004368 glycerol-3-phosphate dehydrogenase activity GSVIVG01012536001 896341 941202 GO:0006744 ubiquinone biosynthetic process The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor. IEA GO:0004368 glycerol-3-phosphate dehydrogenase activity GSVIVG01012536001 896341 941202 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor. IEA GO:0004368 glycerol-3-phosphate dehydrogenase activity GSVIVG01012536001 896341 941202 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor. IEA GO:0004368 glycerol-3-phosphate dehydrogenase activity GSVIVG01012536001 896341 941202 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01012536001 896341 941202 GO:0006744 ubiquinone biosynthetic process The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01012536001 896341 941202 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01012536001 896341 941202 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01012536001 896341 941202 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01012536001 896341 941202 GO:0006744 ubiquinone biosynthetic process The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01012536001 896341 941202 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01012536001 896341 941202 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01012536001 896341 941202 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor. IEA GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen GSVIVG01012536001 896341 941202 GO:0006744 ubiquinone biosynthetic process The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor. IEA GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen GSVIVG01012536001 896341 941202 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor. IEA GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen GSVIVG01012536001 896341 941202 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor. IEA GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen GSVIVG01012536001 896341 941202 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01012536001 896341 941202 GO:0006744 ubiquinone biosynthetic process The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01012536001 896341 941202 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01012536001 896341 941202 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01025776001 11991163 11995881 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025776001 11991163 11995881 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025776001 11991163 11995881 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01021308001 3793214 3809170 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01004833001 5514038 5514631 GSVIVG01030915001 18926529 18934070 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01030915001 18926529 18934070 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008498001 1326721 1332448 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01023099001 22605027 22612724 GSVIVG01013212001 6683686 6683850 GSVIVG01036039001 7704572 7722920 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01036039001 7704572 7722920 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01036039001 7704572 7722920 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01036039001 7704572 7722920 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01036039001 7704572 7722920 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01036039001 7704572 7722920 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01036039001 7704572 7722920 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01036039001 7704572 7722920 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01036039001 7704572 7722920 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate. IEA GO:0019001 guanyl nucleotide binding GSVIVG01036039001 7704572 7722920 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate. IEA GO:0019001 guanyl nucleotide binding GSVIVG01036039001 7704572 7722920 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate. IEA GO:0019001 guanyl nucleotide binding GSVIVG01036039001 7704572 7722920 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate. IEA GO:0019001 guanyl nucleotide binding GSVIVG01034478001 20712864 20713579 GSVIVG01030163001 10916913 10921854 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030163001 10916913 10921854 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01030163001 10916913 10921854 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01008479001 1512042 1517370 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01023892001 2630925 2639037 GSVIVG01000559001 7085350 7086909 GSVIVG01022039001 3924641 3931374 GSVIVG01012059001 1727284 1732878 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004185 serine-type carboxypeptidase activity GSVIVG01028003001 3119888 3120737 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028003001 3119888 3120737 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01028003001 3119888 3120737 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01021709001 9868607 9872737 GSVIVG01033603001 19397337 19399211 GSVIVG01000499001 15084233 15089024 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01000499001 15084233 15089024 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01000499001 15084233 15089024 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01000499001 15084233 15089024 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01000499001 15084233 15089024 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01000499001 15084233 15089024 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01015529001 4591568 4601658 GSVIVG01006471001 26256663 26262083 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01006471001 26256663 26262083 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01006471001 26256663 26262083 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01006471001 26256663 26262083 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01006471001 26256663 26262083 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032724001 1250047 1253132 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01032724001 1250047 1253132 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01032724001 1250047 1253132 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01032724001 1250047 1253132 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01032689001 1519993 1526390 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01032689001 1519993 1526390 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01032689001 1519993 1526390 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01032689001 1519993 1526390 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01003344001 9195281 9199203 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003344001 9195281 9199203 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01003344001 9195281 9199203 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01007337001 31429534 31430897 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GSVIVG01015676001 15416131 15426803 GO:0009231 riboflavin biosynthetic process The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). IEA Catalysis of the reaction: GTP + 3 H2O = formate + 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine + diphosphate. IEA GO:0003935 GTP cyclohydrolase II activity GSVIVG01015676001 15416131 15426803 GO:0009664 plant-type cell wall organization A process that results in the assembly and arrangement of constituent parts of the cellulose and pectin-containing cell wall, or in the disassembly of the cellulose and pectin-containing cell wall. This process is carried out at the cellular level. An example of this process is found in Arabidopsis thaliana. IEA Catalysis of the reaction: GTP + 3 H2O = formate + 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine + diphosphate. IEA GO:0003935 GTP cyclohydrolase II activity GSVIVG01015676001 15416131 15426803 GO:0009231 riboflavin biosynthetic process The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). IEA Catalysis of the reaction: ribulose-5-phosphate = 3,4-dihydroxy-2-butanone-4-phosphate + formate. IEA GO:0008686 3,4-dihydroxy-2-butanone-4-phosphate synthase activity GSVIVG01015676001 15416131 15426803 GO:0009664 plant-type cell wall organization A process that results in the assembly and arrangement of constituent parts of the cellulose and pectin-containing cell wall, or in the disassembly of the cellulose and pectin-containing cell wall. This process is carried out at the cellular level. An example of this process is found in Arabidopsis thaliana. IEA Catalysis of the reaction: ribulose-5-phosphate = 3,4-dihydroxy-2-butanone-4-phosphate + formate. IEA GO:0008686 3,4-dihydroxy-2-butanone-4-phosphate synthase activity GSVIVG01012031001 2006896 2039042 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01012031001 2006896 2039042 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01012031001 2006896 2039042 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01012031001 2006896 2039042 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01012031001 2006896 2039042 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01012031001 2006896 2039042 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011050001 1965832 1974453 GSVIVG01038677001 21059702 21062011 GSVIVG01035504001 1854679 1857192 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035504001 1854679 1857192 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035504001 1854679 1857192 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035504001 1854679 1857192 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01035504001 1854679 1857192 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01035504001 1854679 1857192 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01035315001 399139 400374 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01035315001 399139 400374 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023622001 8125072 8132088 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004185 serine-type carboxypeptidase activity GSVIVG01038039001 16626400 16627945 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. IEA GO:0004364 glutathione transferase activity GSVIVG01027536001 15935795 15939061 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01027536001 15935795 15939061 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01027536001 15935795 15939061 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01027536001 15935795 15939061 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010732001 21889277 21892133 GSVIVG01016222001 6359432 6366650 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor. IEA GO:0004368 glycerol-3-phosphate dehydrogenase activity GSVIVG01016222001 6359432 6366650 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor. IEA GO:0004368 glycerol-3-phosphate dehydrogenase activity GSVIVG01016222001 6359432 6366650 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016222001 6359432 6366650 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01000784001 124452 133238 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01000784001 124452 133238 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01000784001 124452 133238 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01000784001 124452 133238 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025486001 391904 393052 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01025486001 391904 393052 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01025486001 391904 393052 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01025486001 391904 393052 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025486001 391904 393052 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01025486001 391904 393052 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01019861001 3929625 3930580 GSVIVG01027495001 16213715 16216733 GSVIVG01037777001 7772106 7775176 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GSVIVG01037777001 7772106 7775176 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GSVIVG01036933001 17415540 17416971 GSVIVG01034151001 14807129 14811307 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019815001 3558065 3566452 GSVIVG01005024001 17268179 17281716 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GSVIVG01031321001 387626 389749 GSVIVG01033242001 22249846 22254119 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation Splicing of tRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons. IEA Catalysis of the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron. IEA GO:0000213 tRNA-intron endonuclease activity GSVIVG01011168001 7652568 7656300 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01024820001 6639147 6648651 GSVIVG01029866001 759121 761091 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029866001 759121 761091 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029866001 759121 761091 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029866001 759121 761091 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029866001 759121 761091 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029866001 759121 761091 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029866001 759121 761091 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01029866001 759121 761091 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01029866001 759121 761091 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01029866001 759121 761091 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01029866001 759121 761091 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01029866001 759121 761091 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01029866001 759121 761091 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01029866001 759121 761091 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01029866001 759121 761091 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01029866001 759121 761091 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01029866001 759121 761091 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01029866001 759121 761091 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01029866001 759121 761091 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01029866001 759121 761091 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01029866001 759121 761091 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01029866001 759121 761091 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01029866001 759121 761091 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01029866001 759121 761091 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01011567001 6420881 6421718 GO:0006869 lipid transport The directed movement of lipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Interacting selectively and non-covalently with a lipid. IEA GO:0008289 lipid binding GSVIVG01035675001 3199793 3211964 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035675001 3199793 3211964 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035675001 3199793 3211964 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035675001 3199793 3211964 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035675001 3199793 3211964 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035675001 3199793 3211964 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035675001 3199793 3211964 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035675001 3199793 3211964 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035675001 3199793 3211964 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035675001 3199793 3211964 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035675001 3199793 3211964 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035675001 3199793 3211964 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035675001 3199793 3211964 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01035675001 3199793 3211964 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01035675001 3199793 3211964 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01035675001 3199793 3211964 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01035675001 3199793 3211964 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01035675001 3199793 3211964 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01009805001 11384187 11387193 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01031447001 18413852 18414502 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01031447001 18413852 18414502 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01031447001 18413852 18414502 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01023048001 16381443 16399280 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01023048001 16381443 16399280 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01023048001 16381443 16399280 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01023048001 16381443 16399280 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031140001 1799544 1799690 GSVIVG01023928001 2434389 2439692 GSVIVG01017811001 3635848 3639351 GSVIVG01010494001 21046883 21052994 GSVIVG01007593001 11534128 11536699 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01009341001 7553696 7557541 GSVIVG01037069001 8212188 8213029 GSVIVG01014360001 2987859 3003837 GO:0006662 glycerol ether metabolic process The chemical reactions and pathways involving glycerol ethers, any anhydride formed between two organic hydroxy compounds, one of which is glycerol. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01014360001 2987859 3003837 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01014360001 2987859 3003837 GO:0006662 glycerol ether metabolic process The chemical reactions and pathways involving glycerol ethers, any anhydride formed between two organic hydroxy compounds, one of which is glycerol. IEA Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds. IEA GO:0015035 protein disulfide oxidoreductase activity GSVIVG01014360001 2987859 3003837 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds. IEA GO:0015035 protein disulfide oxidoreductase activity GSVIVG01010152001 16444085 16444672 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01010152001 16444085 16444672 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01010152001 16444085 16444672 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01010152001 16444085 16444672 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01005967001 23020082 23026773 GSVIVG01004698001 15198700 15200707 GSVIVG01025246001 2750334 2755573 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025246001 2750334 2755573 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01025246001 2750334 2755573 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: hydrogen sulfide + 3 oxidized ferredoxin + 3 H2O = sulfite + 3 reduced ferredoxin. IEA GO:0050311 sulfite reductase (ferredoxin) activity GSVIVG01025246001 2750334 2755573 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01025246001 2750334 2755573 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051539 4 iron, 4 sulfur cluster binding GSVIVG01019579001 1706216 1710474 GSVIVG01011336001 8713309 8743943 GSVIVG01013791001 7544632 7545963 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01010654001 15604295 15610940 GSVIVG01027442001 16694018 16697644 GSVIVG01000243001 20454575 20473283 GSVIVG01033384001 21044818 21048514 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033384001 21044818 21048514 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033384001 21044818 21048514 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01033384001 21044818 21048514 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01033384001 21044818 21048514 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01033384001 21044818 21048514 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01033384001 21044818 21048514 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01033384001 21044818 21048514 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01033384001 21044818 21048514 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01033384001 21044818 21048514 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01019139001 16320401 16320930 GSVIVG01030691001 13642422 13643008 GSVIVG01019713001 2652621 2654496 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01020072001 10782020 10787013 GSVIVG01018169001 13646659 13651283 GSVIVG01015671001 15307070 15312521 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01015671001 15307070 15312521 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01018233001 12774946 12779580 GSVIVG01021982001 4731470 4735429 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01021982001 4731470 4735429 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01022325001 18508466 18510038 GSVIVG01014431001 3665667 3667741 GSVIVG01025276001 2522293 2528457 GO:0006081 cellular aldehyde metabolic process The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells. IEA Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+. IEA GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity GSVIVG01025276001 2522293 2528457 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+. IEA GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity GSVIVG01025276001 2522293 2528457 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+. IEA GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity GSVIVG01025276001 2522293 2528457 GO:0006081 cellular aldehyde metabolic process The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025276001 2522293 2528457 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025276001 2522293 2528457 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022165001 17178281 17182379 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01022165001 17178281 17182379 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of the reaction: 2 L-ascorbate + O2 = 2 dehydroascorbate + 2 H2O. IEA GO:0008447 L-ascorbate oxidase activity GSVIVG01022165001 17178281 17182379 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022165001 17178281 17182379 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01028035001 3333706 3336114 GO:0006904 vesicle docking involved in exocytosis The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis. IEA GO:0000145 exocyst A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals. IEA GSVIVG01017710001 2837645 2844052 GO:0006338 chromatin remodeling Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation. IEA GO:0000228 nuclear chromosome A chromosome found in the nucleus of a eukaryotic cell. IEA GSVIVG01024393001 2058438 2061520 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA Catalysis of the reaction: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA. IEA GO:0004045 aminoacyl-tRNA hydrolase activity GSVIVG01011867001 3429411 3441168 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01011867001 3429411 3441168 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01010626001 15871014 15873030 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01010626001 15871014 15873030 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01010626001 15871014 15873030 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01010626001 15871014 15873030 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01010626001 15871014 15873030 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01010626001 15871014 15873030 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01033353001 21262667 21267921 GSVIVG01030060001 9326804 9328463 GSVIVG01015155001 1417439 1424337 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01015155001 1417439 1424337 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01015155001 1417439 1424337 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01015155001 1417439 1424337 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034520001 19951232 19959002 GSVIVG01032664001 1679077 1684738 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01016357001 4576653 4617226 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01016357001 4576653 4617226 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01009037001 4453247 4457940 Interacting selectively and non-covalently with a specific domain of a protein. IEA GO:0019904 protein domain specific binding GSVIVG01026726001 5649439 5650151 GSVIVG01025252001 2680765 2687864 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01032793001 727897 730234 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032793001 727897 730234 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. IEA GO:0004722 protein serine/threonine phosphatase activity GSVIVG01027615001 15048077 15051180 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01037915001 6384729 6388220 GO:0009086 methionine biosynthetic process The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. IEA Catalysis of the reaction: ATP + S5-methyl-5-thio-D-ribose = ADP + S5-methyl-5-thio-D-ribose 1-phosphate. IEA GO:0046522 S-methyl-5-thioribose kinase activity GSVIVG01012825001 5766519 5776338 GO:0005985 sucrose metabolic process The chemical reactions and pathways involving sucrose, the disaccharide fructofuranosyl-glucopyranoside. IEA Catalysis of the reaction: UDP-glucose + D-fructose 6-phosphate = UDP + sucrose 6-phosphate. IEA GO:0046524 sucrose-phosphate synthase activity GSVIVG01012825001 5766519 5776338 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: UDP-glucose + D-fructose 6-phosphate = UDP + sucrose 6-phosphate. IEA GO:0046524 sucrose-phosphate synthase activity GSVIVG01010755001 22209669 22216151 GSVIVG01017534001 10076635 10077526 GSVIVG01016487001 3468026 3471879 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016487001 3468026 3471879 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016487001 3468026 3471879 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016487001 3468026 3471879 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016487001 3468026 3471879 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01016487001 3468026 3471879 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01016487001 3468026 3471879 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01016487001 3468026 3471879 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01016487001 3468026 3471879 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016487001 3468026 3471879 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016487001 3468026 3471879 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016487001 3468026 3471879 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016487001 3468026 3471879 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01016487001 3468026 3471879 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01016487001 3468026 3471879 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01016487001 3468026 3471879 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01016487001 3468026 3471879 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016487001 3468026 3471879 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016487001 3468026 3471879 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016487001 3468026 3471879 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016487001 3468026 3471879 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01016487001 3468026 3471879 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01016487001 3468026 3471879 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01016487001 3468026 3471879 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01038750001 449279 455512 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01038750001 449279 455512 Catalysis of the reaction: (5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl-amino acid. IEA GO:0003840 gamma-glutamyltransferase activity GSVIVG01038750001 449279 455512 Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor). IEA GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups GSVIVG01003880001 13067321 13077739 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01003880001 13067321 13077739 Catalysis of the reaction: ATP + shikimate = ADP + shikimate 3-phosphate. IEA GO:0004765 shikimate kinase activity GSVIVG01003880001 13067321 13077739 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003880001 13067321 13077739 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01028960001 17053735 17055618 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01006740001 27936330 27938537 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01006740001 27936330 27938537 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01006740001 27936330 27938537 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01006740001 27936330 27938537 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031736001 3918250 3929199 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid. IEA GO:0008417 fucosyltransferase activity GSVIVG01020737001 2463290 2469852 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01020737001 2463290 2469852 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01020737001 2463290 2469852 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01020737001 2463290 2469852 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01020737001 2463290 2469852 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01020737001 2463290 2469852 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01020737001 2463290 2469852 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01020737001 2463290 2469852 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01020737001 2463290 2469852 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01020737001 2463290 2469852 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01019103001 16738840 16740771 GSVIVG01005237001 19739700 19740680 GSVIVG01031377001 19360714 19368397 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01031377001 19360714 19368397 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031377001 19360714 19368397 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01031377001 19360714 19368397 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01009963001 12863066 12871523 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01009151001 5565992 5604360 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA GSVIVG01015048001 710305 712851 GO:0006744 ubiquinone biosynthetic process The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme. IEA GSVIVG01023018001 16837094 16844931 GO:0042254 ribosome biogenesis The process of the formation of the constituents of the ribosome subunits, their assembly, and their transport to the sites of protein synthesis. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA GSVIVG01023198001 21234362 21235842 GSVIVG01025306001 2243105 2245820 GSVIVG01029593001 20973735 20988914 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01029593001 20973735 20988914 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01029593001 20973735 20988914 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01025006001 5345269 5349794 GO:0006189 'de novo' IMP biosynthetic process The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate. IEA Catalysis of the reaction: 10-formyltetrahydrofolate + H2O = formate + tetrahydrofolate. IEA GO:0008864 formyltetrahydrofolate deformylase activity GSVIVG01025006001 5345269 5349794 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 10-formyltetrahydrofolate + H2O = formate + tetrahydrofolate. IEA GO:0008864 formyltetrahydrofolate deformylase activity GSVIVG01025006001 5345269 5349794 GO:0006189 'de novo' IMP biosynthetic process The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate. IEA Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. IEA GO:0016597 amino acid binding GSVIVG01025006001 5345269 5349794 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. IEA GO:0016597 amino acid binding GSVIVG01011129001 1339352 1346941 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01011129001 1339352 1346941 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01005812001 22012368 22013571 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GSVIVG01005812001 22012368 22013571 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GSVIVG01005812001 22012368 22013571 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01005812001 22012368 22013571 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01000400001 7523260 7526215 GO:0009416 response to light stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01000400001 7523260 7526215 GO:0009416 response to light stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01010833001 23192258 23192899 GSVIVG01034512001 20094188 20140310 GSVIVG01031564001 18213733 18216635 GSVIVG01031094001 2409024 2427876 GSVIVG01030115001 9993753 9994071 GSVIVG01029047001 11374926 11376714 GSVIVG01029152001 19033881 19047271 GSVIVG01028388001 6966501 6971074 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01028388001 6966501 6971074 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01026010001 25889127 25897069 GSVIVG01037131001 28788084 28791193 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01001054001 7117221 7118869 GSVIVG01028773001 18986474 18988399 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01026720001 5465388 5523591 GSVIVG01016518001 3190368 3193037 GSVIVG01034842001 22524258 22527030 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01034842001 22524258 22527030 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01034842001 22524258 22527030 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01034842001 22524258 22527030 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01034842001 22524258 22527030 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01034842001 22524258 22527030 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01034842001 22524258 22527030 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01034842001 22524258 22527030 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01018836001 19432465 19434260 GO:0006370 mRNA capping Addition of the 7-methylguanosine cap to the 5' end of a nascent messenger RNA transcript. IEA GSVIVG01000959001 22279454 22280781 GSVIVG01010525001 21460123 21461397 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01010525001 21460123 21461397 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01005382001 40011380 40012054 GSVIVG01034230001 13099804 13108318 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01034230001 13099804 13108318 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01034230001 13099804 13108318 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015934 large ribosomal subunit The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01034230001 13099804 13108318 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01034230001 13099804 13108318 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01034230001 13099804 13108318 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015934 large ribosomal subunit The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01008670001 1084791 1087907 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01008670001 1084791 1087907 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01008670001 1084791 1087907 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01008670001 1084791 1087907 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01022305001 18375461 18383076 GO:0008219 cell death A biological process that results in permanent cessation of all vital functions of a cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01022305001 18375461 18383076 GO:0008219 cell death A biological process that results in permanent cessation of all vital functions of a cell. IEA GO:0030077 plasma membrane light-harvesting complex A plasma membrane protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center. Examples of this complex are found in bacterial species. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01022305001 18375461 18383076 GO:0009772 photosynthetic electron transport in photosystem II Electrons move from the primary electron acceptor (Quinone, Q) through a chain of electron transport molecules in the thylakoid membrane until they reach the ultimate electron acceptor of Photosystem II, which is plastocyanin (PC). The electron is then passed to the P700 chlorophyll a molecules of the reaction centre of photosystem I. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01022305001 18375461 18383076 GO:0009772 photosynthetic electron transport in photosystem II Electrons move from the primary electron acceptor (Quinone, Q) through a chain of electron transport molecules in the thylakoid membrane until they reach the ultimate electron acceptor of Photosystem II, which is plastocyanin (PC). The electron is then passed to the P700 chlorophyll a molecules of the reaction centre of photosystem I. IEA GO:0030077 plasma membrane light-harvesting complex A plasma membrane protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center. Examples of this complex are found in bacterial species. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01022305001 18375461 18383076 GO:0019684 photosynthesis, light reaction The light reactions of photosynthesis, which take place in photosystems II and I. Light energy is harvested and used to power the transfer of electrons among a series of electron donors and acceptors. The final electron acceptor is NADP+, which is reduced to NADPH. NADPH generated from light reactions is used in sugar synthesis in dark reactions. Light reactions also generate a proton motive force across the thylakoid membrane, and the proton gradient is used to synthesize ATP. There are two chemical reactions involved in the light reactions: water oxidation in photosystem II, and NADP reduction in photosystem I. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01022305001 18375461 18383076 GO:0019684 photosynthesis, light reaction The light reactions of photosynthesis, which take place in photosystems II and I. Light energy is harvested and used to power the transfer of electrons among a series of electron donors and acceptors. The final electron acceptor is NADP+, which is reduced to NADPH. NADPH generated from light reactions is used in sugar synthesis in dark reactions. Light reactions also generate a proton motive force across the thylakoid membrane, and the proton gradient is used to synthesize ATP. There are two chemical reactions involved in the light reactions: water oxidation in photosystem II, and NADP reduction in photosystem I. IEA GO:0030077 plasma membrane light-harvesting complex A plasma membrane protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center. Examples of this complex are found in bacterial species. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01013817001 4762235 4763087 GSVIVG01010260001 18533069 18533527 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01010260001 18533069 18533527 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01004352001 38214848 38216818 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01004352001 38214848 38216818 GO:0019295 coenzyme M biosynthetic process The chemical reactions and pathways resulting in the formation of coenzyme M (2-thioethansulfonate), a coenzyme involved in the utilization of methane by methanogenic prokaryotes. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018073001 6228732 6235627 GSVIVG01009825001 11577344 11581941 GSVIVG01020844001 1153818 1168477 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA GSVIVG01017599001 1914035 1924596 GSVIVG01001356001 23901546 23902200 GSVIVG01011895001 3210000 3211373 GSVIVG01018460001 14755512 14756695 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01023976001 1964776 1967268 GSVIVG01008799001 2203013 2218030 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a nucleotidyl group to a reactant. IEA GO:0016779 nucleotidyltransferase activity GSVIVG01031243001 901493 909964 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026924001 19364506 19367799 GSVIVG01008288001 3623091 3624481 GO:0009853 photorespiration A light-dependent catabolic process occurring concomitantly with photosynthesis in plants (especially C3 plants) whereby dioxygen (O2) is consumed and carbon dioxide (CO2) is evolved. The substrate is glycolate formed in large quantities in chloroplasts from 2-phosphoglycolate generated from ribulose 1,5-bisphosphate by the action of ribulose-bisphosphate carboxylase; the glycolate enters the peroxisomes where it is converted by glycolate oxidase to glyoxylate which undergoes transamination to glycine. This then passes into the mitochondria where it is decarboxylated forming one molecule of serine for every two molecules of glycine. This pathway also exists in photosynthetic bacteria. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01008288001 3623091 3624481 GO:0015977 carbon fixation A metabolic process in which carbon (usually derived from carbon dioxide) is incorporated into organic compounds (usually carbohydrates). IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01008288001 3623091 3624481 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01008288001 3623091 3624481 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01008288001 3623091 3624481 GO:0009853 photorespiration A light-dependent catabolic process occurring concomitantly with photosynthesis in plants (especially C3 plants) whereby dioxygen (O2) is consumed and carbon dioxide (CO2) is evolved. The substrate is glycolate formed in large quantities in chloroplasts from 2-phosphoglycolate generated from ribulose 1,5-bisphosphate by the action of ribulose-bisphosphate carboxylase; the glycolate enters the peroxisomes where it is converted by glycolate oxidase to glyoxylate which undergoes transamination to glycine. This then passes into the mitochondria where it is decarboxylated forming one molecule of serine for every two molecules of glycine. This pathway also exists in photosynthetic bacteria. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008288001 3623091 3624481 GO:0015977 carbon fixation A metabolic process in which carbon (usually derived from carbon dioxide) is incorporated into organic compounds (usually carbohydrates). IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008288001 3623091 3624481 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008288001 3623091 3624481 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008288001 3623091 3624481 GO:0009853 photorespiration A light-dependent catabolic process occurring concomitantly with photosynthesis in plants (especially C3 plants) whereby dioxygen (O2) is consumed and carbon dioxide (CO2) is evolved. The substrate is glycolate formed in large quantities in chloroplasts from 2-phosphoglycolate generated from ribulose 1,5-bisphosphate by the action of ribulose-bisphosphate carboxylase; the glycolate enters the peroxisomes where it is converted by glycolate oxidase to glyoxylate which undergoes transamination to glycine. This then passes into the mitochondria where it is decarboxylated forming one molecule of serine for every two molecules of glycine. This pathway also exists in photosynthetic bacteria. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01008288001 3623091 3624481 GO:0015977 carbon fixation A metabolic process in which carbon (usually derived from carbon dioxide) is incorporated into organic compounds (usually carbohydrates). IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01008288001 3623091 3624481 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01008288001 3623091 3624481 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01008288001 3623091 3624481 GO:0009853 photorespiration A light-dependent catabolic process occurring concomitantly with photosynthesis in plants (especially C3 plants) whereby dioxygen (O2) is consumed and carbon dioxide (CO2) is evolved. The substrate is glycolate formed in large quantities in chloroplasts from 2-phosphoglycolate generated from ribulose 1,5-bisphosphate by the action of ribulose-bisphosphate carboxylase; the glycolate enters the peroxisomes where it is converted by glycolate oxidase to glyoxylate which undergoes transamination to glycine. This then passes into the mitochondria where it is decarboxylated forming one molecule of serine for every two molecules of glycine. This pathway also exists in photosynthetic bacteria. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Catalysis of the reaction: D-ribulose 1,5-bisphosphate + CO2 + H2O = 2 3-phospho-D-glycerate. IEA GO:0016984 ribulose-bisphosphate carboxylase activity GSVIVG01008288001 3623091 3624481 GO:0015977 carbon fixation A metabolic process in which carbon (usually derived from carbon dioxide) is incorporated into organic compounds (usually carbohydrates). IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Catalysis of the reaction: D-ribulose 1,5-bisphosphate + CO2 + H2O = 2 3-phospho-D-glycerate. IEA GO:0016984 ribulose-bisphosphate carboxylase activity GSVIVG01008288001 3623091 3624481 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Catalysis of the reaction: D-ribulose 1,5-bisphosphate + CO2 + H2O = 2 3-phospho-D-glycerate. IEA GO:0016984 ribulose-bisphosphate carboxylase activity GSVIVG01008288001 3623091 3624481 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Catalysis of the reaction: D-ribulose 1,5-bisphosphate + CO2 + H2O = 2 3-phospho-D-glycerate. IEA GO:0016984 ribulose-bisphosphate carboxylase activity GSVIVG01008993001 4121977 4123291 GSVIVG01038114001 23559760 23567531 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01038114001 23559760 23567531 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01038114001 23559760 23567531 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA GO:0008061 chitin binding GSVIVG01038114001 23559760 23567531 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA GO:0008061 chitin binding GSVIVG01009284001 6960144 6962232 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009284001 6960144 6962232 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). IEA GO:0016769 transferase activity, transferring nitrogenous groups GSVIVG01009284001 6960144 6962232 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + methylthioadenosine. IEA GO:0016847 1-aminocyclopropane-1-carboxylate synthase activity GSVIVG01009284001 6960144 6962232 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01028001001 3112052 3117247 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028001001 3112052 3117247 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01028001001 3112052 3117247 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01011153001 7372411 7376699 GSVIVG01020800001 1834886 1839561 GO:0006351 transcription, DNA-dependent The cellular synthesis of RNA on a template of DNA. IEA GO:0030880 RNA polymerase complex Any complex that possesses RNA polymerase activity; generally comprises a catalytic subunit and one or more additional subunits. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01020800001 1834886 1839561 GO:0006351 transcription, DNA-dependent The cellular synthesis of RNA on a template of DNA. IEA GO:0030880 RNA polymerase complex Any complex that possesses RNA polymerase activity; generally comprises a catalytic subunit and one or more additional subunits. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01009746001 10937032 10940276 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009746001 10937032 10940276 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01009746001 10937032 10940276 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01032383001 26847692 26853716 GO:0001522 pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01032383001 26847692 26853716 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01032383001 26847692 26853716 GO:0009451 RNA modification The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01032383001 26847692 26853716 GO:0001522 pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs. IEA Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. IEA GO:0009982 pseudouridine synthase activity GSVIVG01032383001 26847692 26853716 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. IEA GO:0009982 pseudouridine synthase activity GSVIVG01032383001 26847692 26853716 GO:0009451 RNA modification The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. IEA Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. IEA GO:0009982 pseudouridine synthase activity GSVIVG01031568001 18285916 18286302 GSVIVG01025849001 11228118 11229239 GSVIVG01021759001 10675636 10698700 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01021759001 10675636 10698700 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01021759001 10675636 10698700 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01021759001 10675636 10698700 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019808001 3503767 3505105 GSVIVG01006688001 27546043 27550726 GSVIVG01024003001 1801663 1806587 GSVIVG01027979001 2935341 2937863 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01011712001 4866664 4868192 GSVIVG01033874001 17094556 17098033 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01033874001 17094556 17098033 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033434001 20711428 20720404 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035474001 1557587 1570570 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035474001 1557587 1570570 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035474001 1557587 1570570 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035474001 1557587 1570570 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035474001 1557587 1570570 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035474001 1557587 1570570 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035474001 1557587 1570570 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035474001 1557587 1570570 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035474001 1557587 1570570 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01035474001 1557587 1570570 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01035474001 1557587 1570570 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01035474001 1557587 1570570 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01035474001 1557587 1570570 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01035474001 1557587 1570570 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01035474001 1557587 1570570 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01035474001 1557587 1570570 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01035474001 1557587 1570570 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035474001 1557587 1570570 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035474001 1557587 1570570 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035474001 1557587 1570570 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035474001 1557587 1570570 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035474001 1557587 1570570 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035474001 1557587 1570570 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035474001 1557587 1570570 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035474001 1557587 1570570 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01035474001 1557587 1570570 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01035474001 1557587 1570570 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01035474001 1557587 1570570 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01035474001 1557587 1570570 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01035474001 1557587 1570570 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01035474001 1557587 1570570 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01035474001 1557587 1570570 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01035474001 1557587 1570570 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01035474001 1557587 1570570 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01035474001 1557587 1570570 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01035474001 1557587 1570570 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01035474001 1557587 1570570 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01035474001 1557587 1570570 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01035474001 1557587 1570570 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01035474001 1557587 1570570 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01035474001 1557587 1570570 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01035474001 1557587 1570570 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01035474001 1557587 1570570 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01035474001 1557587 1570570 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01035474001 1557587 1570570 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01035474001 1557587 1570570 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01035474001 1557587 1570570 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01035474001 1557587 1570570 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01035474001 1557587 1570570 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01035474001 1557587 1570570 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01035474001 1557587 1570570 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01035474001 1557587 1570570 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01035474001 1557587 1570570 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01035474001 1557587 1570570 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01035474001 1557587 1570570 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01035474001 1557587 1570570 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01028557001 9767526 9773674 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028557001 9767526 9773674 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01001466001 21215050 21233597 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001466001 21215050 21233597 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001466001 21215050 21233597 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001466001 21215050 21233597 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001466001 21215050 21233597 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01001466001 21215050 21233597 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01001466001 21215050 21233597 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01001466001 21215050 21233597 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01001466001 21215050 21233597 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001466001 21215050 21233597 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001466001 21215050 21233597 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001466001 21215050 21233597 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001466001 21215050 21233597 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of calcium (Ca) ions from one side of a membrane to the other. IEA GO:0015085 calcium ion transmembrane transporter activity GSVIVG01001466001 21215050 21233597 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of calcium (Ca) ions from one side of a membrane to the other. IEA GO:0015085 calcium ion transmembrane transporter activity GSVIVG01001466001 21215050 21233597 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of calcium (Ca) ions from one side of a membrane to the other. IEA GO:0015085 calcium ion transmembrane transporter activity GSVIVG01001466001 21215050 21233597 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of calcium (Ca) ions from one side of a membrane to the other. IEA GO:0015085 calcium ion transmembrane transporter activity GSVIVG01001466001 21215050 21233597 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01001466001 21215050 21233597 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01001466001 21215050 21233597 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01001466001 21215050 21233597 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01001466001 21215050 21233597 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01001466001 21215050 21233597 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01001466001 21215050 21233597 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01001466001 21215050 21233597 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01012557001 3556695 3560291 GSVIVG01025708001 12797230 12797604 GSVIVG01001270001 4870557 4875422 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01001270001 4870557 4875422 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01014757001 9346610 9346837 GSVIVG01036516001 22957850 22959479 GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. IEA GO:0005179 hormone activity GSVIVG01034548001 19593287 19597222 GO:0006662 glycerol ether metabolic process The chemical reactions and pathways involving glycerol ethers, any anhydride formed between two organic hydroxy compounds, one of which is glycerol. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01034548001 19593287 19597222 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01034548001 19593287 19597222 GO:0006662 glycerol ether metabolic process The chemical reactions and pathways involving glycerol ethers, any anhydride formed between two organic hydroxy compounds, one of which is glycerol. IEA Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds. IEA GO:0015035 protein disulfide oxidoreductase activity GSVIVG01034548001 19593287 19597222 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds. IEA GO:0015035 protein disulfide oxidoreductase activity GSVIVG01020778001 2098119 2115241 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01020778001 2098119 2115241 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01020778001 2098119 2115241 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01020778001 2098119 2115241 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020778001 2098119 2115241 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01019925001 4502244 4503046 GSVIVG01010016001 13489003 13490580 GSVIVG01008457001 1818132 1823808 GSVIVG01014647001 8202624 8204603 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01014647001 8202624 8204603 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01009585001 9656811 9660267 GSVIVG01013133001 7864283 7866175 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01022689001 15039760 15044339 GSVIVG01003650001 11681244 11683145 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01003650001 11681244 11683145 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. IEA GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity GSVIVG01003650001 11681244 11683145 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032866001 116907 121973 GSVIVG01026961001 19006595 19008436 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01025804001 11673290 11682299 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function that links a sequence-specific transcription factor to the core RNA polymerase II complex but does not bind DNA itself. IEA GO:0003712 transcription cofactor activity GSVIVG01025804001 11673290 11682299 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01038569001 21791255 21794906 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016183001 6937306 6997858 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016183001 6937306 6997858 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01016183001 6937306 6997858 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01016183001 6937306 6997858 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of (1,6)-a-D-glucosidic linkages in pullulan [a linear polymer of a-(1,6)-linked maltotriose units] and in amylopectin and glycogen, and the a- and b-limit dextrins of amylopectin and glycogen. IEA GO:0051060 pullulanase activity GSVIVG01008882001 3097502 3101041 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA GSVIVG01011333001 8652926 8654824 GSVIVG01035421001 1184232 1193195 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008237 metallopeptidase activity GSVIVG01035421001 1184232 1193195 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01026596001 21237941 21239744 GSVIVG01023870001 2864534 2872609 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01023870001 2864534 2872609 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01023870001 2864534 2872609 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01023870001 2864534 2872609 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01023870001 2864534 2872609 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01023870001 2864534 2872609 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01023870001 2864534 2872609 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01023870001 2864534 2872609 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01023870001 2864534 2872609 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01023870001 2864534 2872609 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01023870001 2864534 2872609 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01023870001 2864534 2872609 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01023870001 2864534 2872609 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01023870001 2864534 2872609 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01023870001 2864534 2872609 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01023870001 2864534 2872609 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01023870001 2864534 2872609 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01023870001 2864534 2872609 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01023870001 2864534 2872609 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01023870001 2864534 2872609 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01023870001 2864534 2872609 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01023870001 2864534 2872609 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01023870001 2864534 2872609 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01023870001 2864534 2872609 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01023870001 2864534 2872609 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01023870001 2864534 2872609 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01023870001 2864534 2872609 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01023870001 2864534 2872609 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01023870001 2864534 2872609 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01023870001 2864534 2872609 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01023870001 2864534 2872609 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01023870001 2864534 2872609 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01023870001 2864534 2872609 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01023870001 2864534 2872609 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01023870001 2864534 2872609 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01023870001 2864534 2872609 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01028594001 10376427 10377056 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with manganese (Mn) ions. IEA GO:0030145 manganese ion binding GSVIVG01028594001 10376427 10377056 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Functions in the storage of nutritious substrates. IEA GO:0045735 nutrient reservoir activity GSVIVG01020191001 9240779 9243586 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01033770001 17981702 17987695 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0000015 phosphopyruvate hydratase complex A multimeric enzyme complex, usually a dimer or an octamer, that catalyzes the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate and water. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01033770001 17981702 17987695 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0000015 phosphopyruvate hydratase complex A multimeric enzyme complex, usually a dimer or an octamer, that catalyzes the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate and water. IEA Catalysis of the reaction: 2-phospho-D-glycerate = phosphoenolpyruvate + H2O. IEA GO:0004634 phosphopyruvate hydratase activity GSVIVG01035358001 727412 730203 GSVIVG01017069001 3943920 3947904 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01017069001 3943920 3947904 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017069001 3943920 3947904 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01017069001 3943920 3947904 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. IEA GO:0048037 cofactor binding GSVIVG01017069001 3943920 3947904 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01024160001 690085 693321 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01024160001 690085 693321 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01024160001 690085 693321 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01015548001 4745386 4749039 GSVIVG01017777001 3407937 3408713 GSVIVG01034281001 14039134 14046531 GSVIVG01020267001 22071842 22074329 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020267001 22071842 22074329 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020267001 22071842 22074329 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020267001 22071842 22074329 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020267001 22071842 22074329 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020267001 22071842 22074329 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020267001 22071842 22074329 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01020267001 22071842 22074329 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01037423001 14009729 14010388 GSVIVG01019014001 17782217 17785665 GO:0016481 negative regulation of transcription Any cellular process that stops, prevents or reduces the frequency, rate or extent of transcription. IEA Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0010181 FMN binding GSVIVG01019014001 17782217 17785665 GO:0016481 negative regulation of transcription Any cellular process that stops, prevents or reduces the frequency, rate or extent of transcription. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01013821001 4844050 4846623 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01013821001 4844050 4846623 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01013821001 4844050 4846623 GO:0006422 aspartyl-tRNA aminoacylation The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01013821001 4844050 4846623 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01013821001 4844050 4846623 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01013821001 4844050 4846623 GO:0006422 aspartyl-tRNA aminoacylation The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01013821001 4844050 4846623 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp). IEA GO:0004815 aspartate-tRNA ligase activity GSVIVG01013821001 4844050 4846623 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp). IEA GO:0004815 aspartate-tRNA ligase activity GSVIVG01013821001 4844050 4846623 GO:0006422 aspartyl-tRNA aminoacylation The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp). IEA GO:0004815 aspartate-tRNA ligase activity GSVIVG01013821001 4844050 4846623 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013821001 4844050 4846623 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013821001 4844050 4846623 GO:0006422 aspartyl-tRNA aminoacylation The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001614001 18495150 18499455 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01001614001 18495150 18499455 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01001614001 18495150 18499455 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01001614001 18495150 18499455 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01001614001 18495150 18499455 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001614001 18495150 18499455 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008681001 1170164 1172152 GSVIVG01032396001 26950298 26953373 GSVIVG01037912001 6398081 6398768 GSVIVG01034453001 21096664 21096914 GSVIVG01032708001 1345932 1347522 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01032708001 1345932 1347522 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01032708001 1345932 1347522 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01032708001 1345932 1347522 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018049001 5795282 5806818 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01008808001 2306432 2323070 GSVIVG01034015001 15836617 15865946 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m). IEA GO:0003910 DNA ligase (ATP) activity GSVIVG01034015001 15836617 15865946 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m). IEA GO:0003910 DNA ligase (ATP) activity GSVIVG01034015001 15836617 15865946 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m). IEA GO:0003910 DNA ligase (ATP) activity GSVIVG01034015001 15836617 15865946 GO:0006370 mRNA capping Addition of the 7-methylguanosine cap to the 5' end of a nascent messenger RNA transcript. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m). IEA GO:0003910 DNA ligase (ATP) activity GSVIVG01034015001 15836617 15865946 GO:0006397 mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m). IEA GO:0003910 DNA ligase (ATP) activity GSVIVG01034015001 15836617 15865946 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m). IEA GO:0003910 DNA ligase (ATP) activity GSVIVG01034015001 15836617 15865946 GO:0016311 dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m). IEA GO:0003910 DNA ligase (ATP) activity GSVIVG01034015001 15836617 15865946 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: GTP + (5')pp-Pur-mRNA = diphosphate + G(5')ppp-Pur-mRNA; G(5')ppp-Pur-mRNA is mRNA containing a guanosine residue linked 5' through three phosphates to the 5' position of the terminal residue. IEA GO:0004484 mRNA guanylyltransferase activity GSVIVG01034015001 15836617 15865946 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: GTP + (5')pp-Pur-mRNA = diphosphate + G(5')ppp-Pur-mRNA; G(5')ppp-Pur-mRNA is mRNA containing a guanosine residue linked 5' through three phosphates to the 5' position of the terminal residue. IEA GO:0004484 mRNA guanylyltransferase activity GSVIVG01034015001 15836617 15865946 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: GTP + (5')pp-Pur-mRNA = diphosphate + G(5')ppp-Pur-mRNA; G(5')ppp-Pur-mRNA is mRNA containing a guanosine residue linked 5' through three phosphates to the 5' position of the terminal residue. IEA GO:0004484 mRNA guanylyltransferase activity GSVIVG01034015001 15836617 15865946 GO:0006370 mRNA capping Addition of the 7-methylguanosine cap to the 5' end of a nascent messenger RNA transcript. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: GTP + (5')pp-Pur-mRNA = diphosphate + G(5')ppp-Pur-mRNA; G(5')ppp-Pur-mRNA is mRNA containing a guanosine residue linked 5' through three phosphates to the 5' position of the terminal residue. IEA GO:0004484 mRNA guanylyltransferase activity GSVIVG01034015001 15836617 15865946 GO:0006397 mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: GTP + (5')pp-Pur-mRNA = diphosphate + G(5')ppp-Pur-mRNA; G(5')ppp-Pur-mRNA is mRNA containing a guanosine residue linked 5' through three phosphates to the 5' position of the terminal residue. IEA GO:0004484 mRNA guanylyltransferase activity GSVIVG01034015001 15836617 15865946 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: GTP + (5')pp-Pur-mRNA = diphosphate + G(5')ppp-Pur-mRNA; G(5')ppp-Pur-mRNA is mRNA containing a guanosine residue linked 5' through three phosphates to the 5' position of the terminal residue. IEA GO:0004484 mRNA guanylyltransferase activity GSVIVG01034015001 15836617 15865946 GO:0016311 dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: GTP + (5')pp-Pur-mRNA = diphosphate + G(5')ppp-Pur-mRNA; G(5')ppp-Pur-mRNA is mRNA containing a guanosine residue linked 5' through three phosphates to the 5' position of the terminal residue. IEA GO:0004484 mRNA guanylyltransferase activity GSVIVG01034015001 15836617 15865946 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: 5'-phosphopolynucleotide + H2O = polynucleotide + phosphate. IEA GO:0004651 polynucleotide 5'-phosphatase activity GSVIVG01034015001 15836617 15865946 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: 5'-phosphopolynucleotide + H2O = polynucleotide + phosphate. IEA GO:0004651 polynucleotide 5'-phosphatase activity GSVIVG01034015001 15836617 15865946 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: 5'-phosphopolynucleotide + H2O = polynucleotide + phosphate. IEA GO:0004651 polynucleotide 5'-phosphatase activity GSVIVG01034015001 15836617 15865946 GO:0006370 mRNA capping Addition of the 7-methylguanosine cap to the 5' end of a nascent messenger RNA transcript. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: 5'-phosphopolynucleotide + H2O = polynucleotide + phosphate. IEA GO:0004651 polynucleotide 5'-phosphatase activity GSVIVG01034015001 15836617 15865946 GO:0006397 mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: 5'-phosphopolynucleotide + H2O = polynucleotide + phosphate. IEA GO:0004651 polynucleotide 5'-phosphatase activity GSVIVG01034015001 15836617 15865946 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: 5'-phosphopolynucleotide + H2O = polynucleotide + phosphate. IEA GO:0004651 polynucleotide 5'-phosphatase activity GSVIVG01034015001 15836617 15865946 GO:0016311 dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: 5'-phosphopolynucleotide + H2O = polynucleotide + phosphate. IEA GO:0004651 polynucleotide 5'-phosphatase activity GSVIVG01034015001 15836617 15865946 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. IEA GO:0004725 protein tyrosine phosphatase activity GSVIVG01034015001 15836617 15865946 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. IEA GO:0004725 protein tyrosine phosphatase activity GSVIVG01034015001 15836617 15865946 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. IEA GO:0004725 protein tyrosine phosphatase activity GSVIVG01034015001 15836617 15865946 GO:0006370 mRNA capping Addition of the 7-methylguanosine cap to the 5' end of a nascent messenger RNA transcript. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. IEA GO:0004725 protein tyrosine phosphatase activity GSVIVG01034015001 15836617 15865946 GO:0006397 mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. IEA GO:0004725 protein tyrosine phosphatase activity GSVIVG01034015001 15836617 15865946 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. IEA GO:0004725 protein tyrosine phosphatase activity GSVIVG01034015001 15836617 15865946 GO:0016311 dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. IEA GO:0004725 protein tyrosine phosphatase activity GSVIVG01034015001 15836617 15865946 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034015001 15836617 15865946 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034015001 15836617 15865946 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034015001 15836617 15865946 GO:0006370 mRNA capping Addition of the 7-methylguanosine cap to the 5' end of a nascent messenger RNA transcript. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034015001 15836617 15865946 GO:0006397 mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034015001 15836617 15865946 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034015001 15836617 15865946 GO:0016311 dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034015001 15836617 15865946 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: protein serine/threonine/tyrosine phosphate + H2O = protein serine/threonine/tyrosine + phosphate. IEA GO:0008138 protein tyrosine/serine/threonine phosphatase activity GSVIVG01034015001 15836617 15865946 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: protein serine/threonine/tyrosine phosphate + H2O = protein serine/threonine/tyrosine + phosphate. IEA GO:0008138 protein tyrosine/serine/threonine phosphatase activity GSVIVG01034015001 15836617 15865946 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: protein serine/threonine/tyrosine phosphate + H2O = protein serine/threonine/tyrosine + phosphate. IEA GO:0008138 protein tyrosine/serine/threonine phosphatase activity GSVIVG01034015001 15836617 15865946 GO:0006370 mRNA capping Addition of the 7-methylguanosine cap to the 5' end of a nascent messenger RNA transcript. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: protein serine/threonine/tyrosine phosphate + H2O = protein serine/threonine/tyrosine + phosphate. IEA GO:0008138 protein tyrosine/serine/threonine phosphatase activity GSVIVG01034015001 15836617 15865946 GO:0006397 mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: protein serine/threonine/tyrosine phosphate + H2O = protein serine/threonine/tyrosine + phosphate. IEA GO:0008138 protein tyrosine/serine/threonine phosphatase activity GSVIVG01034015001 15836617 15865946 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: protein serine/threonine/tyrosine phosphate + H2O = protein serine/threonine/tyrosine + phosphate. IEA GO:0008138 protein tyrosine/serine/threonine phosphatase activity GSVIVG01034015001 15836617 15865946 GO:0016311 dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: protein serine/threonine/tyrosine phosphate + H2O = protein serine/threonine/tyrosine + phosphate. IEA GO:0008138 protein tyrosine/serine/threonine phosphatase activity GSVIVG01034015001 15836617 15865946 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. IEA GO:0016791 phosphatase activity GSVIVG01034015001 15836617 15865946 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. IEA GO:0016791 phosphatase activity GSVIVG01034015001 15836617 15865946 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. IEA GO:0016791 phosphatase activity GSVIVG01034015001 15836617 15865946 GO:0006370 mRNA capping Addition of the 7-methylguanosine cap to the 5' end of a nascent messenger RNA transcript. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. IEA GO:0016791 phosphatase activity GSVIVG01034015001 15836617 15865946 GO:0006397 mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. IEA GO:0016791 phosphatase activity GSVIVG01034015001 15836617 15865946 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. IEA GO:0016791 phosphatase activity GSVIVG01034015001 15836617 15865946 GO:0016311 dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. IEA GO:0016791 phosphatase activity GSVIVG01021772001 10904043 10905189 GO:0006869 lipid transport The directed movement of lipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Interacting selectively and non-covalently with a lipid. IEA GO:0008289 lipid binding GSVIVG01015574001 5107196 5107848 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01014550001 5047220 5053973 GO:0006370 mRNA capping Addition of the 7-methylguanosine cap to the 5' end of a nascent messenger RNA transcript. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01014550001 5047220 5053973 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01029740001 13979311 13981578 GSVIVG01020355001 20683310 20804352 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01020355001 20683310 20804352 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with molybdenum (Mo) ions. IEA GO:0030151 molybdenum ion binding GSVIVG01020355001 20683310 20804352 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01013888001 6121318 6122857 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01013888001 6121318 6122857 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031445001 18430616 18434643 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004185 serine-type carboxypeptidase activity GSVIVG01017385001 7730774 7740756 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017385001 7730774 7740756 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01007778001 9127964 9162243 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01007747001 9616919 9618379 GSVIVG01034524001 19886386 19888873 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01015273001 2313320 2319394 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015273001 2313320 2319394 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01015273001 2313320 2319394 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01015273001 2313320 2319394 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01012035001 1973842 1978367 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GSVIVG01036060001 21267523 21269325 GSVIVG01026740001 5929307 5931886 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018113001 6644454 6647555 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01018113001 6644454 6647555 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01018113001 6644454 6647555 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015935 small ribosomal subunit The smaller of the two subunits of a ribosome. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01018113001 6644454 6647555 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01018113001 6644454 6647555 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01018113001 6644454 6647555 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015935 small ribosomal subunit The smaller of the two subunits of a ribosome. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01011367001 29010761 29014596 GO:0006909 phagocytosis The process whereby phagocytes engulf external particulate material. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles. IEA GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA GSVIVG01029024001 10874084 10886526 GSVIVG01032851001 247988 257139 GO:0000162 tryptophan biosynthetic process The chemical reactions and pathways resulting in the formation of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; tryptophan is synthesized from chorismate via anthranilate. IEA Catalysis of the reaction: chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate. IEA GO:0004049 anthranilate synthase activity GSVIVG01032851001 247988 257139 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate. IEA GO:0004049 anthranilate synthase activity GSVIVG01032851001 247988 257139 GO:0000162 tryptophan biosynthetic process The chemical reactions and pathways resulting in the formation of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; tryptophan is synthesized from chorismate via anthranilate. IEA Catalysis of the cleavage of a C-C bond by other means than by hydrolysis or oxidation, of a 3-hydroxy acid. IEA GO:0016833 oxo-acid-lyase activity GSVIVG01032851001 247988 257139 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the cleavage of a C-C bond by other means than by hydrolysis or oxidation, of a 3-hydroxy acid. IEA GO:0016833 oxo-acid-lyase activity GSVIVG01025655001 13268964 13272455 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025655001 13268964 13272455 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01025655001 13268964 13272455 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01003146001 6255542 6256035 GSVIVG01001747001 728066 729117 GSVIVG01008568001 818277 823191 GSVIVG01003253001 8364016 8371626 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01003253001 8364016 8371626 GO:0006270 DNA-dependent DNA replication initiation The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01003253001 8364016 8371626 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01003253001 8364016 8371626 GO:0006270 DNA-dependent DNA replication initiation The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01003253001 8364016 8371626 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003253001 8364016 8371626 GO:0006270 DNA-dependent DNA replication initiation The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003253001 8364016 8371626 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01003253001 8364016 8371626 GO:0006270 DNA-dependent DNA replication initiation The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01008157001 5221016 5227890 GSVIVG01014159001 921705 942345 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014159001 921705 942345 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032264001 14220218 14221031 GSVIVG01035798001 4451360 4455011 GSVIVG01019448001 757936 763421 GSVIVG01027434001 16765296 16768433 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01027434001 16765296 16768433 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01033865001 17161355 17165609 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA GSVIVG01018842001 19379547 19383896 GO:0006081 cellular aldehyde metabolic process The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells. IEA Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+. IEA GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity GSVIVG01018842001 19379547 19383896 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+. IEA GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity GSVIVG01018842001 19379547 19383896 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+. IEA GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity GSVIVG01018842001 19379547 19383896 GO:0006081 cellular aldehyde metabolic process The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01018842001 19379547 19383896 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01018842001 19379547 19383896 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01027632001 14837949 14838725 GSVIVG01005613001 40884802 40887487 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01005613001 40884802 40887487 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01005613001 40884802 40887487 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01005613001 40884802 40887487 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA Catalysis of the reaction: tRNA-uracil + acceptor = tRNA-dihydrouridine + reduced acceptor. IEA GO:0017150 tRNA dihydrouridine synthase activity GSVIVG01005613001 40884802 40887487 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: tRNA-uracil + acceptor = tRNA-dihydrouridine + reduced acceptor. IEA GO:0017150 tRNA dihydrouridine synthase activity GSVIVG01005613001 40884802 40887487 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: tRNA-uracil + acceptor = tRNA-dihydrouridine + reduced acceptor. IEA GO:0017150 tRNA dihydrouridine synthase activity GSVIVG01005613001 40884802 40887487 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01005613001 40884802 40887487 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01005613001 40884802 40887487 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01023838001 3067416 3068111 GSVIVG01031193001 1309089 1314409 Interacting selectively and non-covalently with single-stranded DNA. IEA GO:0003697 single-stranded DNA binding GSVIVG01013991001 8591915 8616007 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01008062001 6151295 6153981 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01020240001 8670276 8675422 GSVIVG01013155001 7471764 7480504 GO:0032312 regulation of ARF GTPase activity Any process that modulates the activity of the GTPase ARF. IEA Increases the rate of GTP hydrolysis by the GTPase ARF. IEA GO:0008060 ARF GTPase activator activity GSVIVG01013155001 7471764 7480504 GO:0032312 regulation of ARF GTPase activity Any process that modulates the activity of the GTPase ARF. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01026366001 15108283 15109209 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01009392001 7962292 7964509 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01009392001 7962292 7964509 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01016800001 1508673 1510267 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01016577001 2659299 2659835 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01016577001 2659299 2659835 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01016577001 2659299 2659835 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01016577001 2659299 2659835 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01016577001 2659299 2659835 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA IEA GO:0016986 transcription initiation factor activity GSVIVG01016577001 2659299 2659835 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA IEA GO:0016986 transcription initiation factor activity GSVIVG01016577001 2659299 2659835 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA IEA GO:0016986 transcription initiation factor activity GSVIVG01016577001 2659299 2659835 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA IEA GO:0016986 transcription initiation factor activity GSVIVG01028668001 11904614 11904790 GSVIVG01013367001 927341 932130 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: 2 H2O2 = O2 + 2 H2O. IEA GO:0004096 catalase activity GSVIVG01013367001 927341 932130 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2 H2O2 = O2 + 2 H2O. IEA GO:0004096 catalase activity GSVIVG01013367001 927341 932130 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01013367001 927341 932130 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01013367001 927341 932130 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01013367001 927341 932130 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01002109001 32987329 32989526 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01002109001 32987329 32989526 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01002109001 32987329 32989526 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01002109001 32987329 32989526 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01002109001 32987329 32989526 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01002109001 32987329 32989526 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01002109001 32987329 32989526 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01002109001 32987329 32989526 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022979001 17330171 17344555 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01022979001 17330171 17344555 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01022979001 17330171 17344555 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01022979001 17330171 17344555 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01022979001 17330171 17344555 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01022979001 17330171 17344555 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01022979001 17330171 17344555 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01022979001 17330171 17344555 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01022979001 17330171 17344555 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022979001 17330171 17344555 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022979001 17330171 17344555 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022979001 17330171 17344555 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027592001 15233488 15237831 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA GSVIVG01027592001 15233488 15237831 GO:0019941 modification-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA GSVIVG01004337001 38172906 38173785 GSVIVG01021429001 5247774 5263945 GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01021429001 5247774 5263945 GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021429001 5247774 5263945 GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nickel (Ni) ions. IEA GO:0016151 nickel ion binding GSVIVG01021429001 5247774 5263945 GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01021584001 7439798 7441049 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009522 photosystem I A photosystem that contains an iron-sulfur reaction center associated with accessory pigments and electron carriers. In cyanobacteria and chloroplasts, photosystem I functions as a light-dependent plastocyanin-ferredoxin oxidoreductase, transferring electrons from plastocyanin to ferredoxin; in photosynthetic bacteria that have only a single type I photosystem, such as the green sulfur bacteria, electrons can go either to ferredoxin (Fd) -> NAD+ or to menaquinone (MK) -> Cytb/FeS -> Cytc555 -> photosystem I (cyclic photophosphorylation). IEA GSVIVG01021584001 7439798 7441049 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01004304001 38008985 38012559 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01004304001 38008985 38012559 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01010787001 22578399 22579963 GSVIVG01028962001 17036901 17041425 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01028962001 17036901 17041425 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01013064001 8849438 8856333 GSVIVG01037090001 29249152 29263470 GO:0006415 translational termination The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code). IEA Involved in catalyzing the release of a nascent polypeptide chain from a ribosome. IEA GO:0003747 translation release factor activity GSVIVG01037303001 16128326 16130204 GSVIVG01013778001 7691531 7692677 GSVIVG01026900001 19565383 19568207 GSVIVG01015995001 16973413 17047030 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015995001 16973413 17047030 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015995001 16973413 17047030 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01015995001 16973413 17047030 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01015995001 16973413 17047030 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01015995001 16973413 17047030 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01006090001 41315799 41315831 GSVIVG01015081001 893123 905806 GSVIVG01024563001 8833618 8834348 GO:0006869 lipid transport The directed movement of lipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Interacting selectively and non-covalently with a lipid. IEA GO:0008289 lipid binding GSVIVG01009623001 9960831 10008801 GSVIVG01030360001 4976426 4981040 GSVIVG01022332001 18562064 18572161 GSVIVG01027099001 17967523 17967714 GSVIVG01025978001 26388226 26396921 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01025978001 26388226 26396921 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01025978001 26388226 26396921 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01025978001 26388226 26396921 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01025978001 26388226 26396921 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01025978001 26388226 26396921 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01025978001 26388226 26396921 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01025978001 26388226 26396921 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01025978001 26388226 26396921 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01025978001 26388226 26396921 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01025978001 26388226 26396921 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01025978001 26388226 26396921 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01025978001 26388226 26396921 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01025978001 26388226 26396921 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01025978001 26388226 26396921 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01025978001 26388226 26396921 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01025978001 26388226 26396921 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01025978001 26388226 26396921 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01010951001 2716304 2720793 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of potassium ions (K+) from one side of a membrane to the other. IEA GO:0015079 potassium ion transmembrane transporter activity GSVIVG01001192001 952825 961258 Catalysis of the reaction: S-adenosyl-L-methionine + L-homocysteine = S-adenosyl-L-homocysteine + L-methionine. IEA GO:0008898 homocysteine S-methyltransferase activity GSVIVG01037892001 6633679 6636058 GSVIVG01018448001 14971004 14980269 GSVIVG01000093001 3450502 3462115 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01003870001 23863 39224 GSVIVG01030308001 9152322 9168922 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01002265001 33778170 33778226 GSVIVG01023148001 21976925 21986301 GSVIVG01011175001 7757539 7776163 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor. IEA GO:0003995 acyl-CoA dehydrogenase activity GSVIVG01011175001 7757539 7776163 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor. IEA GO:0003995 acyl-CoA dehydrogenase activity GSVIVG01011175001 7757539 7776163 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01011175001 7757539 7776163 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01011175001 7757539 7776163 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GSVIVG01011175001 7757539 7776163 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GSVIVG01011175001 7757539 7776163 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01011175001 7757539 7776163 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01017937001 4868680 4873486 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01017937001 4868680 4873486 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01017937001 4868680 4873486 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01017937001 4868680 4873486 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01017937001 4868680 4873486 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01017937001 4868680 4873486 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01017937001 4868680 4873486 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01017937001 4868680 4873486 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01009913001 12336995 12339223 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01009913001 12336995 12339223 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01009913001 12336995 12339223 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01009913001 12336995 12339223 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01009913001 12336995 12339223 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01009913001 12336995 12339223 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01009913001 12336995 12339223 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01009913001 12336995 12339223 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01009913001 12336995 12339223 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01009913001 12336995 12339223 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01009913001 12336995 12339223 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01009913001 12336995 12339223 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01009913001 12336995 12339223 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01009913001 12336995 12339223 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01009913001 12336995 12339223 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01009913001 12336995 12339223 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01009913001 12336995 12339223 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01009913001 12336995 12339223 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01009913001 12336995 12339223 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01009913001 12336995 12339223 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01009913001 12336995 12339223 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01009913001 12336995 12339223 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01009913001 12336995 12339223 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01009913001 12336995 12339223 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01009913001 12336995 12339223 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01009913001 12336995 12339223 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01009913001 12336995 12339223 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01017917001 4640935 4642204 GSVIVG01020653001 3410788 3413393 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020653001 3410788 3413393 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020653001 3410788 3413393 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020653001 3410788 3413393 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020653001 3410788 3413393 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020653001 3410788 3413393 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020653001 3410788 3413393 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020653001 3410788 3413393 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020653001 3410788 3413393 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020653001 3410788 3413393 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020653001 3410788 3413393 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01020653001 3410788 3413393 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01020653001 3410788 3413393 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01020653001 3410788 3413393 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01020653001 3410788 3413393 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01020653001 3410788 3413393 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01020653001 3410788 3413393 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01020653001 3410788 3413393 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01020653001 3410788 3413393 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01020653001 3410788 3413393 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01020653001 3410788 3413393 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020653001 3410788 3413393 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020653001 3410788 3413393 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020653001 3410788 3413393 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020653001 3410788 3413393 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020653001 3410788 3413393 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020653001 3410788 3413393 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020653001 3410788 3413393 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020653001 3410788 3413393 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020653001 3410788 3413393 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020653001 3410788 3413393 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01020653001 3410788 3413393 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01020653001 3410788 3413393 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01020653001 3410788 3413393 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01020653001 3410788 3413393 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01020653001 3410788 3413393 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01020653001 3410788 3413393 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01020653001 3410788 3413393 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01020653001 3410788 3413393 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01020653001 3410788 3413393 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01028290001 5731113 5780724 GO:0016459 myosin complex A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01028290001 5731113 5780724 GO:0016459 myosin complex A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. IEA Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate. IEA GO:0003774 motor activity GSVIVG01028290001 5731113 5780724 GO:0016459 myosin complex A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028290001 5731113 5780724 GO:0016459 myosin complex A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01001074001 7290181 7291531 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001074001 7290181 7291531 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001074001 7290181 7291531 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01001074001 7290181 7291531 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01001074001 7290181 7291531 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01001074001 7290181 7291531 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01001074001 7290181 7291531 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01001074001 7290181 7291531 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01038503001 10582024 10582504 GSVIVG01027040001 18416542 18420857 GO:0006351 transcription, DNA-dependent The cellular synthesis of RNA on a template of DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01027040001 18416542 18420857 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01027040001 18416542 18420857 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01027040001 18416542 18420857 GO:0006351 transcription, DNA-dependent The cellular synthesis of RNA on a template of DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01027040001 18416542 18420857 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01027040001 18416542 18420857 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01027040001 18416542 18420857 GO:0006351 transcription, DNA-dependent The cellular synthesis of RNA on a template of DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01027040001 18416542 18420857 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01027040001 18416542 18420857 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01027040001 18416542 18420857 GO:0006351 transcription, DNA-dependent The cellular synthesis of RNA on a template of DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01027040001 18416542 18420857 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01027040001 18416542 18420857 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01017849001 4003640 4006971 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01017849001 4003640 4006971 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. IEA GO:0008173 RNA methyltransferase activity GSVIVG01015355001 2932300 2940529 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01015355001 2932300 2940529 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026886001 19647510 19648076 GSVIVG01007618001 11179544 11181431 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01007618001 11179544 11181431 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01007618001 11179544 11181431 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01007618001 11179544 11181431 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01007618001 11179544 11181431 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01007618001 11179544 11181431 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01009797001 11318759 11330973 GSVIVG01020530001 4758949 4764469 GSVIVG01025172001 3742302 3752006 GO:0009236 cobalamin biosynthetic process The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01034126001 14993068 14998474 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01034126001 14993068 14998474 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0009986 cell surface The external part of the cell wall and/or plasma membrane. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01034126001 14993068 14998474 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01034126001 14993068 14998474 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0009986 cell surface The external part of the cell wall and/or plasma membrane. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01034126001 14993068 14998474 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01034126001 14993068 14998474 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0009986 cell surface The external part of the cell wall and/or plasma membrane. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01034126001 14993068 14998474 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01034126001 14993068 14998474 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0009986 cell surface The external part of the cell wall and/or plasma membrane. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01034126001 14993068 14998474 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01034126001 14993068 14998474 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0009986 cell surface The external part of the cell wall and/or plasma membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01034126001 14993068 14998474 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01034126001 14993068 14998474 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0009986 cell surface The external part of the cell wall and/or plasma membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01034126001 14993068 14998474 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034126001 14993068 14998474 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0009986 cell surface The external part of the cell wall and/or plasma membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034126001 14993068 14998474 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034126001 14993068 14998474 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0009986 cell surface The external part of the cell wall and/or plasma membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031349001 147162 149044 GSVIVG01022856001 18700974 18723282 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01022856001 18700974 18723282 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01022856001 18700974 18723282 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022856001 18700974 18723282 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017641001 2207622 2213580 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01017641001 2207622 2213580 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01017641001 2207622 2213580 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01017641001 2207622 2213580 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01017641001 2207622 2213580 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01017641001 2207622 2213580 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01017641001 2207622 2213580 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01017641001 2207622 2213580 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01017641001 2207622 2213580 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity. IEA GO:0004721 phosphoprotein phosphatase activity GSVIVG01017641001 2207622 2213580 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity. IEA GO:0004721 phosphoprotein phosphatase activity GSVIVG01017641001 2207622 2213580 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity. IEA GO:0004721 phosphoprotein phosphatase activity GSVIVG01017641001 2207622 2213580 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity. IEA GO:0004721 phosphoprotein phosphatase activity GSVIVG01017641001 2207622 2213580 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. IEA GO:0004722 protein serine/threonine phosphatase activity GSVIVG01017641001 2207622 2213580 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. IEA GO:0004722 protein serine/threonine phosphatase activity GSVIVG01017641001 2207622 2213580 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. IEA GO:0004722 protein serine/threonine phosphatase activity GSVIVG01017641001 2207622 2213580 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. IEA GO:0004722 protein serine/threonine phosphatase activity GSVIVG01017641001 2207622 2213580 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01017641001 2207622 2213580 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01017641001 2207622 2213580 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01017641001 2207622 2213580 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01017641001 2207622 2213580 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid. IEA GO:0008378 galactosyltransferase activity GSVIVG01017641001 2207622 2213580 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid. IEA GO:0008378 galactosyltransferase activity GSVIVG01017641001 2207622 2213580 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid. IEA GO:0008378 galactosyltransferase activity GSVIVG01017641001 2207622 2213580 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid. IEA GO:0008378 galactosyltransferase activity GSVIVG01017641001 2207622 2213580 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01017641001 2207622 2213580 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01017641001 2207622 2213580 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01017641001 2207622 2213580 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01017641001 2207622 2213580 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01017641001 2207622 2213580 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01017641001 2207622 2213580 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01017641001 2207622 2213580 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01012745001 24129477 24131119 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01012745001 24129477 24131119 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01012835001 5944684 5946738 GSVIVG01036456001 22298823 22299625 GSVIVG01013505001 1962458 1964036 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01013505001 1962458 1964036 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01003616001 11305240 11306739 GSVIVG01010943001 2800470 2804566 GSVIVG01034107001 15114656 15118998 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01034107001 15114656 15118998 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01034107001 15114656 15118998 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01004793001 94935 103571 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000257001 20600800 20613759 GSVIVG01007150001 5409887 5410351 GSVIVG01003598001 11131191 11133818 GSVIVG01022900001 18179583 18179886 GSVIVG01001774001 3010870 3012172 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GSVIVG01033891001 16964462 16984299 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01004978001 17209372 17213047 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen The transfer of electrons from cytochrome c to oxygen that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex IV. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01004978001 17209372 17213047 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen The transfer of electrons from cytochrome c to oxygen that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex IV. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01004978001 17209372 17213047 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01004978001 17209372 17213047 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01004978001 17209372 17213047 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen The transfer of electrons from cytochrome c to oxygen that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex IV. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01004978001 17209372 17213047 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen The transfer of electrons from cytochrome c to oxygen that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex IV. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01004978001 17209372 17213047 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01004978001 17209372 17213047 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01004978001 17209372 17213047 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen The transfer of electrons from cytochrome c to oxygen that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex IV. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O. IEA GO:0004129 cytochrome-c oxidase activity GSVIVG01004978001 17209372 17213047 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen The transfer of electrons from cytochrome c to oxygen that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex IV. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O. IEA GO:0004129 cytochrome-c oxidase activity GSVIVG01004978001 17209372 17213047 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O. IEA GO:0004129 cytochrome-c oxidase activity GSVIVG01004978001 17209372 17213047 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O. IEA GO:0004129 cytochrome-c oxidase activity GSVIVG01008390001 2564537 2565055 GSVIVG01034579001 19143646 19150562 GSVIVG01021316001 3937807 3951387 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01021316001 3937807 3951387 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021316001 3937807 3951387 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids. IEA GO:0004518 nuclease activity GSVIVG01021007001 15463871 15464144 GSVIVG01000876001 3083868 3084768 GSVIVG01037840001 7291827 7302798 GO:0006364 rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01037840001 7291827 7302798 GO:0006364 rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. IEA GO:0008173 RNA methyltransferase activity GSVIVG01037840001 7291827 7302798 GO:0006364 rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate. IEA GO:0008757 S-adenosylmethionine-dependent methyltransferase activity GSVIVG01037840001 7291827 7302798 GO:0006364 rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01018185001 13453372 13459237 GSVIVG01024241001 136248 137516 GSVIVG01036837001 17811875 17813214 GSVIVG01009435001 8343876 8344046 GSVIVG01007872001 8131829 8135242 GSVIVG01026245001 14765427 14778160 GSVIVG01011562001 6459148 6466696 GSVIVG01026318001 13620070 13635746 GSVIVG01033008001 25034261 25041471 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033008001 25034261 25041471 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033008001 25034261 25041471 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01033008001 25034261 25041471 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01033008001 25034261 25041471 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). IEA GO:0016769 transferase activity, transferring nitrogenous groups GSVIVG01033008001 25034261 25041471 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). IEA GO:0016769 transferase activity, transferring nitrogenous groups GSVIVG01033008001 25034261 25041471 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01033008001 25034261 25041471 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01000124001 15451437 15458048 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01015848001 18320399 18321759 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015848001 18320399 18321759 GO:0008299 isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015848001 18320399 18321759 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA. IEA GO:0004421 hydroxymethylglutaryl-CoA synthase activity GSVIVG01015848001 18320399 18321759 GO:0008299 isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. IEA Catalysis of the reaction: acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA. IEA GO:0004421 hydroxymethylglutaryl-CoA synthase activity GSVIVG01012812001 5636245 5636859 GSVIVG01025364001 1440120 1443717 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025364001 1440120 1443717 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01014502001 4580815 4582002 GSVIVG01015395001 3255776 3256649 GSVIVG01022061001 16292195 16295192 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01031340001 257295 261252 GSVIVG01001887001 6784098 6787453 GSVIVG01027189001 17151471 17154829 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01027189001 17151471 17154829 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01027189001 17151471 17154829 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01027189001 17151471 17154829 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006204001 23668330 23670964 GSVIVG01007338001 31430919 31435685 GSVIVG01035414001 1115013 1118921 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01035414001 1115013 1118921 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01035414001 1115013 1118921 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01035414001 1115013 1118921 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01035414001 1115013 1118921 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01035414001 1115013 1118921 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01035414001 1115013 1118921 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035414001 1115013 1118921 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023714001 9882376 9900820 GO:0048268 clathrin coat assembly The process by which clathrin triskelia are assembled into the ordered structure known as a clathrin cage. IEA GO:0030118 clathrin coat A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes. IEA Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester. IEA GO:0005543 phospholipid binding GSVIVG01023714001 9882376 9900820 GO:0048268 clathrin coat assembly The process by which clathrin triskelia are assembled into the ordered structure known as a clathrin cage. IEA GO:0030118 clathrin coat A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes. IEA Interacting selectively and non-covalently with phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. IEA GO:0005545 phosphatidylinositol binding GSVIVG01023714001 9882376 9900820 GO:0048268 clathrin coat assembly The process by which clathrin triskelia are assembled into the ordered structure known as a clathrin cage. IEA GO:0030118 clathrin coat A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes. IEA Interacting selectively and non-covalently with a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles. IEA GO:0030276 clathrin binding GSVIVG01001305001 5167369 5172416 GSVIVG01018730001 20339633 20342566 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018730001 20339633 20342566 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01018730001 20339633 20342566 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01027934001 9748664 9758707 GSVIVG01010635001 15731445 15733541 GSVIVG01033920001 16731260 16731927 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01033920001 16731260 16731927 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01016722001 653031 655698 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01016722001 653031 655698 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01016722001 653031 655698 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01016722001 653031 655698 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016722001 653031 655698 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01005198001 19082266 19092016 GSVIVG01018618001 12154929 12155585 GSVIVG01009035001 4442137 4445561 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01002941001 37288988 37289665 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018166001 13686972 13688211 GSVIVG01021026001 15099441 15105228 GSVIVG01021165001 2092168 2094082 GSVIVG01022502001 3993760 3999573 GSVIVG01001092001 22596663 22602230 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01001092001 22596663 22602230 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01001092001 22596663 22602230 GO:0006426 glycyl-tRNA aminoacylation The process of coupling glycine to glycyl-tRNA, catalyzed by glycyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01001092001 22596663 22602230 GO:0006433 prolyl-tRNA aminoacylation The process of coupling proline to prolyl-tRNA, catalyzed by prolyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01001092001 22596663 22602230 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01001092001 22596663 22602230 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01001092001 22596663 22602230 GO:0006426 glycyl-tRNA aminoacylation The process of coupling glycine to glycyl-tRNA, catalyzed by glycyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01001092001 22596663 22602230 GO:0006433 prolyl-tRNA aminoacylation The process of coupling proline to prolyl-tRNA, catalyzed by prolyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01001092001 22596663 22602230 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly). IEA GO:0004820 glycine-tRNA ligase activity GSVIVG01001092001 22596663 22602230 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly). IEA GO:0004820 glycine-tRNA ligase activity GSVIVG01001092001 22596663 22602230 GO:0006426 glycyl-tRNA aminoacylation The process of coupling glycine to glycyl-tRNA, catalyzed by glycyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly). IEA GO:0004820 glycine-tRNA ligase activity GSVIVG01001092001 22596663 22602230 GO:0006433 prolyl-tRNA aminoacylation The process of coupling proline to prolyl-tRNA, catalyzed by prolyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly). IEA GO:0004820 glycine-tRNA ligase activity GSVIVG01001092001 22596663 22602230 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro). IEA GO:0004827 proline-tRNA ligase activity GSVIVG01001092001 22596663 22602230 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro). IEA GO:0004827 proline-tRNA ligase activity GSVIVG01001092001 22596663 22602230 GO:0006426 glycyl-tRNA aminoacylation The process of coupling glycine to glycyl-tRNA, catalyzed by glycyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro). IEA GO:0004827 proline-tRNA ligase activity GSVIVG01001092001 22596663 22602230 GO:0006433 prolyl-tRNA aminoacylation The process of coupling proline to prolyl-tRNA, catalyzed by prolyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro). IEA GO:0004827 proline-tRNA ligase activity GSVIVG01001092001 22596663 22602230 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001092001 22596663 22602230 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001092001 22596663 22602230 GO:0006426 glycyl-tRNA aminoacylation The process of coupling glycine to glycyl-tRNA, catalyzed by glycyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001092001 22596663 22602230 GO:0006433 prolyl-tRNA aminoacylation The process of coupling proline to prolyl-tRNA, catalyzed by prolyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036656001 19919578 19924593 GSVIVG01037341001 15452835 15456922 GSVIVG01000861001 3161588 3169606 GSVIVG01001138001 22898900 22922421 GSVIVG01020003001 11757628 11766675 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01020003001 11757628 11766675 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. IEA GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity GSVIVG01020003001 11757628 11766675 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01020003001 11757628 11766675 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031972001 5808410 5815024 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01031972001 5808410 5815024 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01031972001 5808410 5815024 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01031972001 5808410 5815024 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031972001 5808410 5815024 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034463001 20935211 20942470 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01034463001 20935211 20942470 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034463001 20935211 20942470 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01034463001 20935211 20942470 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01018952001 18401347 18413421 GSVIVG01032478001 27762091 27770553 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01011337001 8775354 8898931 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0042151 nematocyst An organelle found in cnidoblast (nematoblast) cells. When matured, these stinging organelles store toxins and can deliver them when the cnidocil (a short extension of the cnidocyst) is stimulated by a prey or another stimulus. IEA Enables the directed movement of acyl groups into, out of, within or between cells. IEA GO:0000036 acyl carrier activity GSVIVG01011337001 8775354 8898931 GO:0009405 pathogenesis The set of specific processes that generate the ability of an organism to cause disease in another. IEA GO:0042151 nematocyst An organelle found in cnidoblast (nematoblast) cells. When matured, these stinging organelles store toxins and can deliver them when the cnidocil (a short extension of the cnidocyst) is stimulated by a prey or another stimulus. IEA Enables the directed movement of acyl groups into, out of, within or between cells. IEA GO:0000036 acyl carrier activity GSVIVG01011337001 8775354 8898931 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0042151 nematocyst An organelle found in cnidoblast (nematoblast) cells. When matured, these stinging organelles store toxins and can deliver them when the cnidocil (a short extension of the cnidocyst) is stimulated by a prey or another stimulus. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01011337001 8775354 8898931 GO:0009405 pathogenesis The set of specific processes that generate the ability of an organism to cause disease in another. IEA GO:0042151 nematocyst An organelle found in cnidoblast (nematoblast) cells. When matured, these stinging organelles store toxins and can deliver them when the cnidocil (a short extension of the cnidocyst) is stimulated by a prey or another stimulus. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01011337001 8775354 8898931 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0042151 nematocyst An organelle found in cnidoblast (nematoblast) cells. When matured, these stinging organelles store toxins and can deliver them when the cnidocil (a short extension of the cnidocyst) is stimulated by a prey or another stimulus. IEA Stops, prevents, or reduces the activity of a sodium channel. IEA GO:0019871 sodium channel inhibitor activity GSVIVG01011337001 8775354 8898931 GO:0009405 pathogenesis The set of specific processes that generate the ability of an organism to cause disease in another. IEA GO:0042151 nematocyst An organelle found in cnidoblast (nematoblast) cells. When matured, these stinging organelles store toxins and can deliver them when the cnidocil (a short extension of the cnidocyst) is stimulated by a prey or another stimulus. IEA Stops, prevents, or reduces the activity of a sodium channel. IEA GO:0019871 sodium channel inhibitor activity GSVIVG01002966001 37476580 37476987 GSVIVG01037523001 12274369 12283288 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01037523001 12274369 12283288 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01018143001 7004077 7020364 GSVIVG01003940001 8219718 8222855 Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01003940001 8219718 8222855 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003940001 8219718 8222855 Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. IEA GO:0016831 carboxy-lyase activity GSVIVG01003940001 8219718 8222855 Interacting selectively and non-covalently with thiamin pyrophosphate, the diphosphoric ester of thiamin. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases. IEA GO:0030976 thiamin pyrophosphate binding GSVIVG01000594001 6701543 6712881 GO:0051205 protein insertion into membrane The process by which a protein is incorporated into a biological membrane. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01012516001 408071 409423 GSVIVG01027384001 15481752 15483069 GSVIVG01035420001 1179166 1183181 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035420001 1179166 1183181 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. IEA GO:0004722 protein serine/threonine phosphatase activity GSVIVG01027401001 17027707 17045754 GSVIVG01014549001 5043980 5046526 GSVIVG01020453001 19180148 19180384 GSVIVG01036879001 18336213 18337133 GSVIVG01035851001 4881183 4886034 GSVIVG01027481001 16430050 16441708 GSVIVG01003948001 13962625 13968360 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01003948001 13962625 13968360 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028857001 18045535 18052668 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001661001 14033384 14034350 GSVIVG01004126001 15103254 15104285 GSVIVG01023115001 22403922 22405945 GSVIVG01016092001 18744451 18788612 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain. IEA GO:0008239 dipeptidyl-peptidase activity GSVIVG01016092001 18744451 18788612 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01013414001 614195 619058 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01013414001 614195 619058 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01013414001 614195 619058 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01013414001 614195 619058 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01028795001 18743092 18743343 GSVIVG01026986001 18789471 18809558 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01018512001 14017550 14023017 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01003754001 12373534 12385308 GSVIVG01016020001 17443183 17447946 GSVIVG01004898001 16571590 16573148 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. IEA GO:0004364 glutathione transferase activity GSVIVG01009811001 11429216 11475051 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and carries out proton transport across a membrane. The proton-transporting domain (F0, V0, or A0) includes integral and peripheral membrane proteins. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01020823001 1518958 1520885 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01020823001 1518958 1520885 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01020823001 1518958 1520885 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001320001 5288438 5296580 GO:0006479 protein amino acid methylation The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01020774001 2158317 2158712 GSVIVG01013040001 9395764 9397535 GSVIVG01027269001 17348150 17350590 GSVIVG01017132001 4464848 4472977 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GSVIVG01027015001 18561659 18564253 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01027015001 18561659 18564253 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01027015001 18561659 18564253 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01027015001 18561659 18564253 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01027015001 18561659 18564253 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01027015001 18561659 18564253 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01027015001 18561659 18564253 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water. IEA GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water GSVIVG01027015001 18561659 18564253 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water. IEA GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water GSVIVG01027015001 18561659 18564253 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water. IEA GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water GSVIVG01027015001 18561659 18564253 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01027015001 18561659 18564253 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01027015001 18561659 18564253 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01014864001 10785518 10830108 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028232001 4811816 4813325 GSVIVG01012447001 915072 922558 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01016313001 5228249 5231188 GO:0006414 translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01016313001 5228249 5231188 GO:0006414 translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01016313001 5228249 5231188 GO:0042254 ribosome biogenesis The process of the formation of the constituents of the ribosome subunits, their assembly, and their transport to the sites of protein synthesis. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01016313001 5228249 5231188 GO:0042254 ribosome biogenesis The process of the formation of the constituents of the ribosome subunits, their assembly, and their transport to the sites of protein synthesis. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01012160001 958551 959737 GSVIVG01028221001 4737490 4738813 GSVIVG01013731001 8105311 8106237 GSVIVG01008180001 4959316 4963930 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01033810001 17586605 17590525 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01033810001 17586605 17590525 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01033810001 17586605 17590525 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01033810001 17586605 17590525 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01002384001 937533 939151 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01028775001 18969068 18978429 GSVIVG01030408001 5330739 5331187 GSVIVG01036387001 4510464 4517611 GSVIVG01027131001 17582079 17582499 GSVIVG01029823001 46445 104512 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01029823001 46445 104512 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01035712001 3540647 3545598 GSVIVG01033840001 17313644 17318728 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c The transfer of electrons from ubiquinol to cytochrome c that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex III. IEA GO:0005740 mitochondrial envelope The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+. IEA GO:0008121 ubiquinol-cytochrome-c reductase activity GSVIVG01004276001 37916265 37916711 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01004276001 37916265 37916711 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01004276001 37916265 37916711 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01004276001 37916265 37916711 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01005413001 40085980 40089818 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01005413001 40085980 40089818 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA Catalysis of the hydrolysis of ester linkages within nucleic acids. IEA GO:0004518 nuclease activity GSVIVG01017204001 5316069 5343724 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01017204001 5316069 5343724 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017204001 5316069 5343724 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01017204001 5316069 5343724 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01026718001 5388307 5392653 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01022123001 16762703 16768736 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion. IEA GO:0004806 triglyceride lipase activity GSVIVG01024164001 666618 670971 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016001001 17166200 17167638 GSVIVG01023128001 22289097 22296036 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023128001 22289097 22296036 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01003143001 6282001 6283721 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01025049001 5012784 5014183 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01024639001 8138163 8139910 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024639001 8138163 8139910 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024639001 8138163 8139910 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01027517001 16020950 16023047 GO:0016559 peroxisome fission The division of a mature peroxisome within a cell to form two or more separate peroxisome compartments. IEA GO:0005778 peroxisomal membrane The lipid bilayer surrounding a peroxisome. IEA GSVIVG01013458001 307575 308424 GSVIVG01037357001 15204661 15228479 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01037357001 15204661 15228479 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005663 DNA replication factor C complex A complex of five polypeptides in eukaryotes, and two in prokaryotes, that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01037357001 15204661 15228479 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01037357001 15204661 15228479 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0005663 DNA replication factor C complex A complex of five polypeptides in eukaryotes, and two in prokaryotes, that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01037357001 15204661 15228479 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01037357001 15204661 15228479 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005663 DNA replication factor C complex A complex of five polypeptides in eukaryotes, and two in prokaryotes, that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01037357001 15204661 15228479 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01037357001 15204661 15228479 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0005663 DNA replication factor C complex A complex of five polypeptides in eukaryotes, and two in prokaryotes, that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01037357001 15204661 15228479 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their closing around the DNA duplex. IEA GO:0003689 DNA clamp loader activity GSVIVG01037357001 15204661 15228479 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005663 DNA replication factor C complex A complex of five polypeptides in eukaryotes, and two in prokaryotes, that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their closing around the DNA duplex. IEA GO:0003689 DNA clamp loader activity GSVIVG01037357001 15204661 15228479 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their closing around the DNA duplex. IEA GO:0003689 DNA clamp loader activity GSVIVG01037357001 15204661 15228479 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0005663 DNA replication factor C complex A complex of five polypeptides in eukaryotes, and two in prokaryotes, that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their closing around the DNA duplex. IEA GO:0003689 DNA clamp loader activity GSVIVG01037357001 15204661 15228479 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037357001 15204661 15228479 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005663 DNA replication factor C complex A complex of five polypeptides in eukaryotes, and two in prokaryotes, that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037357001 15204661 15228479 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037357001 15204661 15228479 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0005663 DNA replication factor C complex A complex of five polypeptides in eukaryotes, and two in prokaryotes, that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037357001 15204661 15228479 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01037357001 15204661 15228479 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005663 DNA replication factor C complex A complex of five polypeptides in eukaryotes, and two in prokaryotes, that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01037357001 15204661 15228479 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01037357001 15204661 15228479 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0005663 DNA replication factor C complex A complex of five polypeptides in eukaryotes, and two in prokaryotes, that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01035448001 1350185 1354369 GO:0007596 blood coagulation The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01035448001 1350185 1354369 GO:0007596 blood coagulation The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01035448001 1350185 1354369 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01035448001 1350185 1354369 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01031265001 691084 693474 GSVIVG01008759001 1758026 1758094 GSVIVG01030880001 18297665 18298470 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01030880001 18297665 18298470 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01030880001 18297665 18298470 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01030880001 18297665 18298470 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01026865001 19807621 19812627 GSVIVG01008804001 2255022 2258087 GSVIVG01038198001 24276952 24279902 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function that links a sequence-specific transcription factor to the core RNA polymerase II complex but does not bind DNA itself. IEA GO:0003712 transcription cofactor activity GSVIVG01038198001 24276952 24279902 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone. IEA GO:0004402 histone acetyltransferase activity GSVIVG01038198001 24276952 24279902 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01038198001 24276952 24279902 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01010035001 13682339 13692522 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01010035001 13682339 13692522 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01022890001 18244520 18246373 GSVIVG01011753001 4493673 4545871 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01011753001 4493673 4545871 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01011753001 4493673 4545871 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate, driving the unwinding of the DNA helix. IEA GO:0004003 ATP-dependent DNA helicase activity GSVIVG01011753001 4493673 4545871 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate, driving the unwinding of the DNA helix. IEA GO:0004003 ATP-dependent DNA helicase activity GSVIVG01011753001 4493673 4545871 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01011753001 4493673 4545871 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01011753001 4493673 4545871 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011753001 4493673 4545871 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011753001 4493673 4545871 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01011753001 4493673 4545871 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01030867001 18013740 18014909 GSVIVG01034254001 13529348 13578374 GSVIVG01015197001 1733867 1756012 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01015197001 1733867 1756012 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015197001 1733867 1756012 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01035689001 3339976 3350798 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01035689001 3339976 3350798 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01035689001 3339976 3350798 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01035689001 3339976 3350798 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01035689001 3339976 3350798 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01035689001 3339976 3350798 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01009366001 7813571 7833032 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01009366001 7813571 7833032 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01009366001 7813571 7833032 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01009366001 7813571 7833032 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01009366001 7813571 7833032 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001944001 15144901 15145881 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01024888001 6225292 6226452 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024888001 6225292 6226452 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024888001 6225292 6226452 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024888001 6225292 6226452 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024888001 6225292 6226452 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024888001 6225292 6226452 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024888001 6225292 6226452 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01024888001 6225292 6226452 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01024888001 6225292 6226452 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01024888001 6225292 6226452 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024888001 6225292 6226452 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024888001 6225292 6226452 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01023877001 2766208 2771472 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01023877001 2766208 2771472 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01023877001 2766208 2771472 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01023877001 2766208 2771472 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033923001 16696524 16697176 GSVIVG01010480001 20940812 20944087 GSVIVG01032439001 27415674 27419367 GO:0000162 tryptophan biosynthetic process The chemical reactions and pathways resulting in the formation of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; tryptophan is synthesized from chorismate via anthranilate. IEA Catalysis of the reaction: N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-a-D-ribose 1-diphosphate. IEA GO:0004048 anthranilate phosphoribosyltransferase activity GSVIVG01032439001 27415674 27419367 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-a-D-ribose 1-diphosphate. IEA GO:0004048 anthranilate phosphoribosyltransferase activity GSVIVG01032439001 27415674 27419367 GO:0000162 tryptophan biosynthetic process The chemical reactions and pathways resulting in the formation of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; tryptophan is synthesized from chorismate via anthranilate. IEA Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01032439001 27415674 27419367 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01011501001 30070300 30072330 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017566001 10636781 10639618 GSVIVG01012104001 1425250 1426536 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012104001 1425250 1426536 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH = peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R. IEA GO:0032542 sulfiredoxin activity GSVIVG01008738001 1566764 1576208 GSVIVG01038721001 20615306 20618269 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01038721001 20615306 20618269 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01038721001 20615306 20618269 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01038721001 20615306 20618269 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037615001 6254701 6263751 GSVIVG01026459001 23237231 23252027 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01026459001 23237231 23252027 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01026459001 23237231 23252027 GO:0006268 DNA unwinding involved in replication The process by which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01026459001 23237231 23252027 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01026459001 23237231 23252027 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01026459001 23237231 23252027 GO:0006268 DNA unwinding involved in replication The process by which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01026459001 23237231 23252027 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA. IEA GO:0003916 DNA topoisomerase activity GSVIVG01026459001 23237231 23252027 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA. IEA GO:0003916 DNA topoisomerase activity GSVIVG01026459001 23237231 23252027 GO:0006268 DNA unwinding involved in replication The process by which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA. IEA GO:0003916 DNA topoisomerase activity GSVIVG01026459001 23237231 23252027 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle. IEA GO:0003917 DNA topoisomerase type I activity GSVIVG01026459001 23237231 23252027 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle. IEA GO:0003917 DNA topoisomerase type I activity GSVIVG01026459001 23237231 23252027 GO:0006268 DNA unwinding involved in replication The process by which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle. IEA GO:0003917 DNA topoisomerase type I activity GSVIVG01025590001 13802791 13803590 GSVIVG01026310001 13400788 13400892 GSVIVG01000773001 702390 707008 GSVIVG01036052001 21346766 21354746 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01036052001 21346766 21354746 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end. IEA GO:0004527 exonuclease activity GSVIVG01009761001 11056811 11061172 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01017071001 3956449 3958756 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009538 photosystem I reaction center A photochemical system containing P700, the chlorophyll a dimer that functions as a primary electron donor. Functioning as a light-dependent plastocyanin-ferredoxin oxidoreductase, it transfers electrons from plastocyanin to ferredoxin. IEA GSVIVG01032511001 27995698 27998537 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + shikimate = ADP + shikimate 3-phosphate. IEA GO:0004765 shikimate kinase activity GSVIVG01032511001 27995698 27998537 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007683001 10459769 10483350 GSVIVG01035944001 6271231 6277645 GSVIVG01025578001 13920962 13934564 GSVIVG01032025001 23425164 23445399 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01032025001 23425164 23445399 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032025001 23425164 23445399 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01032025001 23425164 23445399 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01032025001 23425164 23445399 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01022894001 18216287 18218134 GSVIVG01036689001 23832465 23836195 GO:0006102 isocitrate metabolic process The chemical reactions and pathways involving isocitrate, the anion of isocitric acid, 1-hydroxy-1,2,3-propanetricarboxylic acid. Isocitrate is an important intermediate in the TCA cycle and the glycoxylate cycle. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01036689001 23832465 23836195 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01036689001 23832465 23836195 GO:0006102 isocitrate metabolic process The chemical reactions and pathways involving isocitrate, the anion of isocitric acid, 1-hydroxy-1,2,3-propanetricarboxylic acid. Isocitrate is an important intermediate in the TCA cycle and the glycoxylate cycle. IEA Catalysis of the reaction: isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH + H+. IEA GO:0004450 isocitrate dehydrogenase (NADP+) activity GSVIVG01036689001 23832465 23836195 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH + H+. IEA GO:0004450 isocitrate dehydrogenase (NADP+) activity GSVIVG01036689001 23832465 23836195 GO:0006102 isocitrate metabolic process The chemical reactions and pathways involving isocitrate, the anion of isocitric acid, 1-hydroxy-1,2,3-propanetricarboxylic acid. Isocitrate is an important intermediate in the TCA cycle and the glycoxylate cycle. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01036689001 23832465 23836195 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01036689001 23832465 23836195 GO:0006102 isocitrate metabolic process The chemical reactions and pathways involving isocitrate, the anion of isocitric acid, 1-hydroxy-1,2,3-propanetricarboxylic acid. Isocitrate is an important intermediate in the TCA cycle and the glycoxylate cycle. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01036689001 23832465 23836195 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01008963001 3887490 3898689 GSVIVG01029003001 10543148 10544181 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. IEA GO:0004364 glutathione transferase activity GSVIVG01010206001 17391225 17403345 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01010206001 17391225 17403345 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01010206001 17391225 17403345 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01031826001 4723791 4725151 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01031826001 4723791 4725151 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01018845001 19351213 19359850 GSVIVG01014114001 524432 526729 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014114001 524432 526729 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014114001 524432 526729 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038228001 24490072 24496810 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01038228001 24490072 24496810 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01038228001 24490072 24496810 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01038228001 24490072 24496810 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01034012001 15891485 15895267 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of arsenite from one side of a membrane to the other. IEA GO:0015105 arsenite transmembrane transporter activity GSVIVG01038252001 24695552 24717064 GO:0032957 inositol trisphosphate metabolic process The chemical reactions and pathways involving myo-inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with three phosphate groups attached. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01038252001 24695552 24717064 GO:0032957 inositol trisphosphate metabolic process The chemical reactions and pathways involving myo-inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with three phosphate groups attached. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038252001 24695552 24717064 GO:0032957 inositol trisphosphate metabolic process The chemical reactions and pathways involving myo-inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with three phosphate groups attached. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reactions: ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate and ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate. IEA GO:0035300 inositol-1,3,4-trisphosphate 5/6-kinase activity GSVIVG01038252001 24695552 24717064 GO:0032957 inositol trisphosphate metabolic process The chemical reactions and pathways involving myo-inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with three phosphate groups attached. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: 1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP. IEA GO:0047325 inositol tetrakisphosphate 1-kinase activity GSVIVG01025534001 14247902 14250749 GO:0006270 DNA-dependent DNA replication initiation The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025534001 14247902 14250749 GO:0006270 DNA-dependent DNA replication initiation The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001714001 365035 388375 GSVIVG01021927001 5496829 5498608 GSVIVG01020261001 22143585 22145706 GSVIVG01015223001 1948503 1950590 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01015223001 1948503 1950590 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01015223001 1948503 1950590 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01026122001 24315228 24322276 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01015368001 3057394 3057525 GSVIVG01005412001 40083579 40084748 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01005412001 40083579 40084748 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01005412001 40083579 40084748 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01005412001 40083579 40084748 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01004903001 4671233 4672854 GSVIVG01013634001 1993605 2011353 GSVIVG01027834001 8359943 8367514 GSVIVG01001464001 21208630 21212916 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GSVIVG01001464001 21208630 21212916 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GSVIVG01014640001 8116655 8120740 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with transfer RNA. IEA GO:0000049 tRNA binding GSVIVG01014640001 8116655 8120740 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with transfer RNA. IEA GO:0000049 tRNA binding GSVIVG01014640001 8116655 8120740 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015935 small ribosomal subunit The smaller of the two subunits of a ribosome. IEA Interacting selectively and non-covalently with transfer RNA. IEA GO:0000049 tRNA binding GSVIVG01014640001 8116655 8120740 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01014640001 8116655 8120740 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01014640001 8116655 8120740 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015935 small ribosomal subunit The smaller of the two subunits of a ribosome. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01014640001 8116655 8120740 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01014640001 8116655 8120740 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01014640001 8116655 8120740 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015935 small ribosomal subunit The smaller of the two subunits of a ribosome. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01010364001 19850530 19856793 GSVIVG01000575001 6936328 6938135 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01000575001 6936328 6938135 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01000575001 6936328 6938135 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01000575001 6936328 6938135 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01022852001 18765200 18766166 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01013542001 20437926 20445323 GSVIVG01033078001 25573027 25580767 GSVIVG01038094001 23457927 23461484 GSVIVG01032975001 24741144 24753959 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01001985001 6061478 6062469 GSVIVG01015025001 542212 547987 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01015025001 542212 547987 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01015025001 542212 547987 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01015025001 542212 547987 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01015025001 542212 547987 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01015025001 542212 547987 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01015025001 542212 547987 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01015025001 542212 547987 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01015025001 542212 547987 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01015025001 542212 547987 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01015025001 542212 547987 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01015025001 542212 547987 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01015025001 542212 547987 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces an oxygen molecule. IEA GO:0050664 oxidoreductase activity, acting on NADH or NADPH, with oxygen as acceptor GSVIVG01015025001 542212 547987 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces an oxygen molecule. IEA GO:0050664 oxidoreductase activity, acting on NADH or NADPH, with oxygen as acceptor GSVIVG01023245001 20686937 20688126 Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme. IEA GO:0004867 serine-type endopeptidase inhibitor activity GSVIVG01025691001 12924236 12928912 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025691001 12924236 12928912 GO:0009725 response to hormone stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025691001 12924236 12928912 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025691001 12924236 12928912 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01025691001 12924236 12928912 GO:0009725 response to hormone stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01025691001 12924236 12928912 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01015217001 1892866 1896685 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01033292001 21772582 21775978 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033292001 21772582 21775978 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033292001 21772582 21775978 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033292001 21772582 21775978 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017700001 2751284 2771189 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01017700001 2751284 2771189 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01017700001 2751284 2771189 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01017700001 2751284 2771189 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016268001 5707150 5718261 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. IEA GO:0008080 N-acetyltransferase activity GSVIVG01008191001 4820279 4826327 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: 3-alpha(S)-strictosidine = tryptamine + secologanin. IEA GO:0016844 strictosidine synthase activity GSVIVG01005108001 18180495 18181629 GSVIVG01009104001 5062036 5076971 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01009104001 5062036 5076971 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01009104001 5062036 5076971 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01009104001 5062036 5076971 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01028089001 3715570 3718889 GSVIVG01011263001 10225844 10229298 GSVIVG01036763001 22854358 22885790 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01036763001 22854358 22885790 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01036763001 22854358 22885790 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036763001 22854358 22885790 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01002886001 36968030 36970246 GSVIVG01011963001 2545036 2563372 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01011963001 2545036 2563372 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01011963001 2545036 2563372 GO:0015886 heme transport The directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01011963001 2545036 2563372 GO:0017004 cytochrome complex assembly The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01011963001 2545036 2563372 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01011963001 2545036 2563372 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells. IEA GO:0015232 heme transporter activity GSVIVG01011963001 2545036 2563372 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells. IEA GO:0015232 heme transporter activity GSVIVG01011963001 2545036 2563372 GO:0015886 heme transport The directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells. IEA GO:0015232 heme transporter activity GSVIVG01011963001 2545036 2563372 GO:0017004 cytochrome complex assembly The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells. IEA GO:0015232 heme transporter activity GSVIVG01011963001 2545036 2563372 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells. IEA GO:0015232 heme transporter activity GSVIVG01033614001 19270131 19298262 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01033614001 19270131 19298262 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026998001 18683536 18685264 GSVIVG01019359001 464885 506009 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01019359001 464885 506009 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019359001 464885 506009 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01019359001 464885 506009 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019359001 464885 506009 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009666001 10314905 10317391 GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA GSVIVG01005727001 21754438 21754938 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016471 vacuolar proton-transporting V-type ATPase complex A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01038041001 16675414 16687774 GSVIVG01025512001 129470 138528 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01025512001 129470 138528 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028442001 7601858 7610470 GSVIVG01023151001 21915954 21925197 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01023151001 21915954 21925197 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01023151001 21915954 21925197 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01023151001 21915954 21925197 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01023151001 21915954 21925197 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01023151001 21915954 21925197 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01023151001 21915954 21925197 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01023151001 21915954 21925197 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01023151001 21915954 21925197 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01023151001 21915954 21925197 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01023151001 21915954 21925197 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01023151001 21915954 21925197 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01023151001 21915954 21925197 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01023151001 21915954 21925197 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01023151001 21915954 21925197 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01010127001 15925062 15931368 GSVIVG01022781001 16490275 16499446 GSVIVG01018488001 14381446 14384745 GSVIVG01014922001 12022775 12023370 GSVIVG01011728001 4747827 4748971 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GSVIVG01011728001 4747827 4748971 GO:0009607 response to biotic stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism. IEA GSVIVG01033971001 16207268 16208616 GSVIVG01008453001 1857307 1861479 GSVIVG01020635001 3615415 3627821 Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. IEA GO:0008171 O-methyltransferase activity GSVIVG01010779001 22500903 22503567 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. IEA GO:0004175 endopeptidase activity GSVIVG01010779001 22500903 22503567 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01010779001 22500903 22503567 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01012068001 1652446 1676628 GO:0005795 Golgi stack The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack. IEA Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid. IEA GO:0008378 galactosyltransferase activity GSVIVG01003089001 8571724 8591073 GO:0007205 activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway The initiation of the activity of the inactive enzyme protein kinase C as the result of a series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol 3-phosphate. IEA GO:0004143 diacylglycerol kinase activity GSVIVG01030065001 9413012 9415993 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01022824001 19036194 19038228 GO:0006306 DNA methylation The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01011590001 6168519 6169676 GO:0048268 clathrin coat assembly The process by which clathrin triskelia are assembled into the ordered structure known as a clathrin cage. IEA GO:0030118 clathrin coat A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes. IEA Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester. IEA GO:0005543 phospholipid binding GSVIVG01011590001 6168519 6169676 GO:0048268 clathrin coat assembly The process by which clathrin triskelia are assembled into the ordered structure known as a clathrin cage. IEA GO:0030118 clathrin coat A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes. IEA Interacting selectively and non-covalently with phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. IEA GO:0005545 phosphatidylinositol binding GSVIVG01011590001 6168519 6169676 GO:0048268 clathrin coat assembly The process by which clathrin triskelia are assembled into the ordered structure known as a clathrin cage. IEA GO:0030118 clathrin coat A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes. IEA Interacting selectively and non-covalently with a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles. IEA GO:0030276 clathrin binding GSVIVG01021188001 2431577 2432883 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion. IEA GO:0004806 triglyceride lipase activity GSVIVG01036206001 9058944 9061708 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). IEA GO:0003755 peptidyl-prolyl cis-trans isomerase activity GSVIVG01032527001 28104988 28107423 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01036797001 22420569 22445496 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031225001 1050502 1058003 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+. IEA GO:0004148 dihydrolipoyl dehydrogenase activity GSVIVG01031225001 1050502 1058003 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+. IEA GO:0004148 dihydrolipoyl dehydrogenase activity GSVIVG01031225001 1050502 1058003 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+. IEA GO:0004148 dihydrolipoyl dehydrogenase activity GSVIVG01031225001 1050502 1058003 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+. IEA GO:0004148 dihydrolipoyl dehydrogenase activity GSVIVG01031225001 1050502 1058003 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+. IEA GO:0004148 dihydrolipoyl dehydrogenase activity GSVIVG01031225001 1050502 1058003 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+. IEA GO:0004148 dihydrolipoyl dehydrogenase activity GSVIVG01031225001 1050502 1058003 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+. IEA GO:0004148 dihydrolipoyl dehydrogenase activity GSVIVG01031225001 1050502 1058003 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+. IEA GO:0004148 dihydrolipoyl dehydrogenase activity GSVIVG01031225001 1050502 1058003 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor. IEA GO:0004368 glycerol-3-phosphate dehydrogenase activity GSVIVG01031225001 1050502 1058003 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor. IEA GO:0004368 glycerol-3-phosphate dehydrogenase activity GSVIVG01031225001 1050502 1058003 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor. IEA GO:0004368 glycerol-3-phosphate dehydrogenase activity GSVIVG01031225001 1050502 1058003 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor. IEA GO:0004368 glycerol-3-phosphate dehydrogenase activity GSVIVG01031225001 1050502 1058003 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor. IEA GO:0004368 glycerol-3-phosphate dehydrogenase activity GSVIVG01031225001 1050502 1058003 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor. IEA GO:0004368 glycerol-3-phosphate dehydrogenase activity GSVIVG01031225001 1050502 1058003 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor. IEA GO:0004368 glycerol-3-phosphate dehydrogenase activity GSVIVG01031225001 1050502 1058003 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor. IEA GO:0004368 glycerol-3-phosphate dehydrogenase activity GSVIVG01031225001 1050502 1058003 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01031225001 1050502 1058003 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01031225001 1050502 1058003 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01031225001 1050502 1058003 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01031225001 1050502 1058003 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01031225001 1050502 1058003 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01031225001 1050502 1058003 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01031225001 1050502 1058003 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01031225001 1050502 1058003 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031225001 1050502 1058003 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031225001 1050502 1058003 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031225001 1050502 1058003 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031225001 1050502 1058003 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031225001 1050502 1058003 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031225001 1050502 1058003 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031225001 1050502 1058003 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031225001 1050502 1058003 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01031225001 1050502 1058003 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01031225001 1050502 1058003 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01031225001 1050502 1058003 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01031225001 1050502 1058003 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01031225001 1050502 1058003 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01031225001 1050502 1058003 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01031225001 1050502 1058003 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01031225001 1050502 1058003 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01031225001 1050502 1058003 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01031225001 1050502 1058003 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01031225001 1050502 1058003 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01031225001 1050502 1058003 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01031225001 1050502 1058003 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01031225001 1050502 1058003 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01031225001 1050502 1058003 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01009583001 9625307 9628766 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01009583001 9625307 9628766 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01009583001 9625307 9628766 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01009583001 9625307 9628766 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01009583001 9625307 9628766 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01009583001 9625307 9628766 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01024979001 5555623 5563964 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01024979001 5555623 5563964 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01024979001 5555623 5563964 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01024979001 5555623 5563964 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01024979001 5555623 5563964 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01024979001 5555623 5563964 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01024979001 5555623 5563964 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01024979001 5555623 5563964 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01024979001 5555623 5563964 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01024979001 5555623 5563964 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01024979001 5555623 5563964 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01024979001 5555623 5563964 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01024979001 5555623 5563964 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024979001 5555623 5563964 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024979001 5555623 5563964 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010928001 15517208 15532999 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01010928001 15517208 15532999 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01038577001 21749319 21751201 GO:0006413 translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01038577001 21749319 21751201 GO:0006413 translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. IEA Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. IEA GO:0003743 translation initiation factor activity GSVIVG01009479001 8724790 8727096 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01032673001 1612663 1617095 GSVIVG01031569001 18289490 18297376 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019641001 2141900 2143945 GSVIVG01033751001 18123856 18135276 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01033751001 18123856 18135276 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01027047001 18374875 18376597 GSVIVG01023568001 9494020 9497708 GSVIVG01017210001 5445593 5447655 GO:0009416 response to light stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01013291001 65488 76017 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01013291001 65488 76017 Catalysis of the reaction: ATP + shikimate = ADP + shikimate 3-phosphate. IEA GO:0004765 shikimate kinase activity GSVIVG01013291001 65488 76017 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013291001 65488 76017 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01031798001 4450821 4454744 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028651001 11593558 11595223 GSVIVG01018490001 14344649 14350934 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01018490001 14344649 14350934 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01018490001 14344649 14350934 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01018490001 14344649 14350934 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018490001 14344649 14350934 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012242001 279359 279820 GSVIVG01003704001 15229180 15229604 GSVIVG01036389001 4542034 4542582 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01036389001 4542034 4542582 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01036389001 4542034 4542582 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01036389001 4542034 4542582 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01036389001 4542034 4542582 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01036389001 4542034 4542582 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01033822001 17454776 17460718 Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum. IEA GO:0003993 acid phosphatase activity GSVIVG01033822001 17454776 17460718 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01033822001 17454776 17460718 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01006926001 29125246 29130159 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01006926001 29125246 29130159 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01006926001 29125246 29130159 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the formation of a 2,3-epoxide in squalene. IEA GO:0004506 squalene monooxygenase activity GSVIVG01006926001 29125246 29130159 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the formation of a 2,3-epoxide in squalene. IEA GO:0004506 squalene monooxygenase activity GSVIVG01006926001 29125246 29130159 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01006926001 29125246 29130159 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01006926001 29125246 29130159 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01006926001 29125246 29130159 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01007685001 10423630 10448147 GSVIVG01008249001 4126786 4142234 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA GSVIVG01033267001 22003786 22005472 GSVIVG01027348001 16040740 16066729 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01033303001 21672956 21675817 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01033303001 21672956 21675817 GO:0007047 cellular cell wall organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01033303001 21672956 21675817 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01033303001 21672956 21675817 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01033303001 21672956 21675817 GO:0007047 cellular cell wall organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01033303001 21672956 21675817 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01033303001 21672956 21675817 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01033303001 21672956 21675817 GO:0007047 cellular cell wall organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01033303001 21672956 21675817 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01022251001 17850124 17854660 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01013880001 5887666 5887890 GSVIVG01028336001 6269691 6270625 GSVIVG01021209001 2554953 2565719 GSVIVG01012111001 1343520 1344663 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + Na+(out) = amino acid(in) + Na+(in). IEA GO:0005283 sodium:amino acid symporter activity GSVIVG01035914001 5732353 5739585 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035914001 5732353 5739585 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035914001 5732353 5739585 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate. IEA GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity GSVIVG01035914001 5732353 5739585 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate. IEA GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity GSVIVG01035914001 5732353 5739585 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. IEA GO:0008483 transaminase activity GSVIVG01035914001 5732353 5739585 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. IEA GO:0008483 transaminase activity GSVIVG01035914001 5732353 5739585 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01035914001 5732353 5739585 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01035914001 5732353 5739585 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). IEA GO:0016769 transferase activity, transferring nitrogenous groups GSVIVG01035914001 5732353 5739585 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). IEA GO:0016769 transferase activity, transferring nitrogenous groups GSVIVG01035914001 5732353 5739585 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01035914001 5732353 5739585 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01012688001 655491 656786 GSVIVG01034905001 16296859 16297513 GSVIVG01036583001 18585463 18604171 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01036583001 18585463 18604171 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01036583001 18585463 18604171 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01036583001 18585463 18604171 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01004892001 16480976 16481119 GSVIVG01000316001 11313845 11316805 GO:0008299 isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. IEA GSVIVG01036812001 17293487 17296105 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01036812001 17293487 17296105 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01036812001 17293487 17296105 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01036812001 17293487 17296105 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01036959001 9524910 9527107 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01035430001 1225847 1228461 GSVIVG01031862001 4969557 4976362 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01031862001 4969557 4976362 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01031862001 4969557 4976362 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01031862001 4969557 4976362 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031862001 4969557 4976362 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01031862001 4969557 4976362 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01018908001 18735669 18737405 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01015618001 14136488 14155287 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01009826001 11581989 11587461 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01009826001 11581989 11587461 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01015261001 2175417 2176296 GSVIVG01013795001 7512990 7513366 GSVIVG01023998001 1824920 1835490 GO:0006397 mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023998001 1824920 1835490 GO:0006397 mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01023998001 1824920 1835490 GO:0006397 mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01001286001 4989461 4989778 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01001286001 4989461 4989778 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01034409001 16737697 16747054 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01034409001 16737697 16747054 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01022141001 16910734 16914148 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01022141001 16910734 16914148 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01022141001 16910734 16914148 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01022141001 16910734 16914148 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01016724001 664041 668956 GSVIVG01030607001 7130381 7137097 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013824001 4896297 4897340 GSVIVG01021835001 6689564 6706224 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016197001 6787891 6812746 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GSVIVG01033862001 17169688 17180081 GO:0006614 SRP-dependent cotranslational protein targeting to membrane The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. IEA GO:0048500 signal recognition particle A complex of protein and RNA which facilitates translocation of proteins across membranes. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01033862001 17169688 17180081 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0048500 signal recognition particle A complex of protein and RNA which facilitates translocation of proteins across membranes. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01033862001 17169688 17180081 GO:0006614 SRP-dependent cotranslational protein targeting to membrane The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. IEA GO:0048500 signal recognition particle A complex of protein and RNA which facilitates translocation of proteins across membranes. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033862001 17169688 17180081 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0048500 signal recognition particle A complex of protein and RNA which facilitates translocation of proteins across membranes. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033862001 17169688 17180081 GO:0006614 SRP-dependent cotranslational protein targeting to membrane The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. IEA GO:0048500 signal recognition particle A complex of protein and RNA which facilitates translocation of proteins across membranes. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01033862001 17169688 17180081 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0048500 signal recognition particle A complex of protein and RNA which facilitates translocation of proteins across membranes. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01033862001 17169688 17180081 GO:0006614 SRP-dependent cotranslational protein targeting to membrane The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. IEA GO:0048500 signal recognition particle A complex of protein and RNA which facilitates translocation of proteins across membranes. IEA Interacting selectively and non-covalently with 7S RNA, the RNA component of the signal recognition particle (SRP). IEA GO:0008312 7S RNA binding GSVIVG01033862001 17169688 17180081 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0048500 signal recognition particle A complex of protein and RNA which facilitates translocation of proteins across membranes. IEA Interacting selectively and non-covalently with 7S RNA, the RNA component of the signal recognition particle (SRP). IEA GO:0008312 7S RNA binding GSVIVG01033862001 17169688 17180081 GO:0006614 SRP-dependent cotranslational protein targeting to membrane The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. IEA GO:0048500 signal recognition particle A complex of protein and RNA which facilitates translocation of proteins across membranes. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01033862001 17169688 17180081 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0048500 signal recognition particle A complex of protein and RNA which facilitates translocation of proteins across membranes. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01033826001 17429265 17429498 GSVIVG01036086001 20839462 20862534 GSVIVG01027904001 9220874 9222724 GSVIVG01015508001 4319249 4320559 GSVIVG01026051001 25288684 25288797 GSVIVG01004776001 16010464 16011359 GSVIVG01013573001 21087894 21093137 GSVIVG01005737001 13969701 13971564 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01023044001 16437257 16445082 GSVIVG01015759001 17028352 17034085 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015759001 17028352 17034085 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015759001 17028352 17034085 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2 2-nitropropane + O2 = 2 acetone + 2 NO2(-) (nitrite). IEA GO:0018580 2-nitropropane dioxygenase activity GSVIVG01015759001 17028352 17034085 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2 2-nitropropane + O2 = 2 acetone + 2 NO2(-) (nitrite). IEA GO:0018580 2-nitropropane dioxygenase activity GSVIVG01015585001 5232586 5233563 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01025382001 1215735 1219197 GSVIVG01003481001 10637437 10654208 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01015280001 2360968 2364383 GO:0007010 cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01015280001 2360968 2364383 GO:0007010 cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. IEA GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01015280001 2360968 2364383 GO:0007010 cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01015280001 2360968 2364383 GO:0030036 actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01015280001 2360968 2364383 GO:0030036 actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. IEA GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01015280001 2360968 2364383 GO:0030036 actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01033566001 19709120 19714921 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01033566001 19709120 19714921 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01026359001 14943620 14962982 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01020629001 3659974 3661500 Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. IEA GO:0008171 O-methyltransferase activity GSVIVG01017816001 3685000 3691063 The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01012847001 6073015 6074330 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031800001 4473082 4476262 GSVIVG01022459001 3263145 3264891 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01022459001 3263145 3264891 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01022459001 3263145 3264891 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01022459001 3263145 3264891 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01016312001 5231721 5243840 GO:0006367 transcription initiation from RNA polymerase II promoter A transcription initiation process that results in RNA synthesis by RNA polymerase II. IEA GO:0005674 transcription factor TFIIF complex A general transcription initiation factor which in humans consists of a heterodimer of an alpha and a beta subunit. Helps recruit RNA polymerase II to the initiation complex and promotes translation elongation. IEA Functions to initiate or regulate RNA polymerase II transcription. IEA GO:0003702 RNA polymerase II transcription factor activity GSVIVG01016312001 5231721 5243840 GO:0006367 transcription initiation from RNA polymerase II promoter A transcription initiation process that results in RNA synthesis by RNA polymerase II. IEA GO:0005674 transcription factor TFIIF complex A general transcription initiation factor which in humans consists of a heterodimer of an alpha and a beta subunit. Helps recruit RNA polymerase II to the initiation complex and promotes translation elongation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016312001 5231721 5243840 GO:0006367 transcription initiation from RNA polymerase II promoter A transcription initiation process that results in RNA synthesis by RNA polymerase II. IEA GO:0005674 transcription factor TFIIF complex A general transcription initiation factor which in humans consists of a heterodimer of an alpha and a beta subunit. Helps recruit RNA polymerase II to the initiation complex and promotes translation elongation. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011106001 1525869 1526210 GSVIVG01008533001 1043080 1048331 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01015006001 396544 400278 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01021569001 7174313 7195344 GO:0006519 cellular amino acid and derivative metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021569001 7174313 7195344 GO:0019752 carboxylic acid metabolic process The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021569001 7174313 7195344 GO:0006519 cellular amino acid and derivative metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells. IEA Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. IEA GO:0016831 carboxy-lyase activity GSVIVG01021569001 7174313 7195344 GO:0019752 carboxylic acid metabolic process The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). IEA Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. IEA GO:0016831 carboxy-lyase activity GSVIVG01021569001 7174313 7195344 GO:0006519 cellular amino acid and derivative metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01021569001 7174313 7195344 GO:0019752 carboxylic acid metabolic process The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01019067001 17151856 17154684 GSVIVG01033839001 17322989 17332968 GSVIVG01031547001 17270831 17272824 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01031547001 17270831 17272824 GO:0019941 modification-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01031547001 17270831 17272824 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01031547001 17270831 17272824 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01031547001 17270831 17272824 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031547001 17270831 17272824 GO:0019941 modification-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031547001 17270831 17272824 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031547001 17270831 17272824 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031547001 17270831 17272824 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01031547001 17270831 17272824 GO:0019941 modification-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01031547001 17270831 17272824 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01031547001 17270831 17272824 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01031547001 17270831 17272824 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01031547001 17270831 17272824 GO:0019941 modification-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01031547001 17270831 17272824 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01031547001 17270831 17272824 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01021048001 14661981 14664993 GSVIVG01022620001 13478753 13525358 GSVIVG01036421001 4930209 4932695 GSVIVG01025745001 12291992 12300335 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01025745001 12291992 12300335 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01025745001 12291992 12300335 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01025745001 12291992 12300335 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025745001 12291992 12300335 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009795001 11307616 11310938 GSVIVG01019385001 209926 211742 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01019385001 209926 211742 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008592001 568127 580106 GSVIVG01016814001 1620100 1624105 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01033318001 21558928 21561593 GSVIVG01009080001 4773002 4780140 GSVIVG01015237001 2023389 2032456 GO:0009987 cellular process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. IEA Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain. IEA GO:0004177 aminopeptidase activity GSVIVG01015237001 2023389 2032456 GO:0009987 cellular process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. IEA Interacting selectively and non-covalently with manganese (Mn) ions. IEA GO:0030145 manganese ion binding GSVIVG01018431001 15272480 15276383 GSVIVG01038641001 21269851 21283495 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01038641001 21269851 21283495 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01038641001 21269851 21283495 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01038641001 21269851 21283495 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01000942001 22102565 22108124 GSVIVG01007339001 31435805 31437668 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01013103001 8259203 8260480 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003687001 12135661 12181854 GSVIVG01034257001 13603903 13604907 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01005841001 22189571 22191875 GO:0006308 DNA catabolic process The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01005841001 22189571 22191875 GO:0006308 DNA catabolic process The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. IEA GO:0004519 endonuclease activity GSVIVG01005841001 22189571 22191875 GO:0006308 DNA catabolic process The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01019198001 3670796 3671044 GSVIVG01011167001 7623465 7641697 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01011167001 7623465 7641697 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01011167001 7623465 7641697 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01011167001 7623465 7641697 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01011167001 7623465 7641697 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034809001 21906965 21909587 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01034809001 21906965 21909587 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01034809001 21906965 21909587 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01034809001 21906965 21909587 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01034809001 21906965 21909587 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01034809001 21906965 21909587 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01034809001 21906965 21909587 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01034809001 21906965 21909587 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01034809001 21906965 21909587 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01034809001 21906965 21909587 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01034809001 21906965 21909587 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01034809001 21906965 21909587 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01034809001 21906965 21909587 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034809001 21906965 21909587 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034809001 21906965 21909587 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034809001 21906965 21909587 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034809001 21906965 21909587 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01034809001 21906965 21909587 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01034809001 21906965 21909587 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01034809001 21906965 21909587 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01031722001 3823723 3830160 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01031722001 3823723 3830160 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01031722001 3823723 3830160 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01031722001 3823723 3830160 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027177001 17233810 17234578 GSVIVG01025031001 5136505 5148455 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01023590001 7715926 7721814 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01023590001 7715926 7721814 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01015825001 17935113 17947035 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01000137001 15576353 15579494 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide. IEA GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides GSVIVG01014622001 5768652 5779409 GSVIVG01010346001 19685493 19688706 GSVIVG01038105001 23520466 23524730 GSVIVG01033708001 18446519 18449828 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01033708001 18446519 18449828 Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. IEA GO:0008171 O-methyltransferase activity GSVIVG01033708001 18446519 18449828 The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01024329001 1043887 1045279 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01007888001 7909778 7916412 GSVIVG01024274001 484963 486219 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01024274001 484963 486219 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01024274001 484963 486219 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01024274001 484963 486219 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01017393001 7802281 7803222 GSVIVG01003497001 10774808 10775227 GO:0008219 cell death A biological process that results in permanent cessation of all vital functions of a cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01002505001 35090260 35100032 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH3. IEA GO:0004418 hydroxymethylbilane synthase activity GSVIVG01002505001 35090260 35100032 GO:0033014 tetrapyrrole biosynthetic process The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. IEA Catalysis of the reaction: 4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH3. IEA GO:0004418 hydroxymethylbilane synthase activity GSVIVG01002505001 35090260 35100032 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH3. IEA GO:0004418 hydroxymethylbilane synthase activity GSVIVG01002505001 35090260 35100032 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01002505001 35090260 35100032 GO:0033014 tetrapyrrole biosynthetic process The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01002505001 35090260 35100032 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033753001 18090891 18101173 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01033753001 18090891 18101173 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01033753001 18090891 18101173 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01033753001 18090891 18101173 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033753001 18090891 18101173 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01033753001 18090891 18101173 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01030272001 9639529 9640517 GSVIVG01038447001 12518294 12520356 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01003078001 8339529 8354567 GSVIVG01032009001 23595417 23596136 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032009001 23595417 23596136 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01032009001 23595417 23596136 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01016863001 2079795 2081318 GSVIVG01001137001 22897010 22897774 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01001137001 22897010 22897774 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01030021001 8979854 8980044 GSVIVG01029476001 22433209 22433544 GSVIVG01015019001 494466 497941 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Stops, prevents or reduces the activity of an enzyme. IEA GO:0004857 enzyme inhibitor activity GSVIVG01015019001 494466 497941 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the reaction: pectin + n H2O = n methanol + pectate. IEA GO:0030599 pectinesterase activity GSVIVG01035427001 1213611 1221561 GSVIVG01000981001 11113910 11119234 GSVIVG01022920001 18030513 18043335 GSVIVG01015359001 2971817 2974633 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01015359001 2971817 2974633 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01015359001 2971817 2974633 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01015359001 2971817 2974633 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01015359001 2971817 2974633 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01015359001 2971817 2974633 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01015359001 2971817 2974633 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01015359001 2971817 2974633 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01015359001 2971817 2974633 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01015359001 2971817 2974633 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01015359001 2971817 2974633 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01015359001 2971817 2974633 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01015359001 2971817 2974633 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01015359001 2971817 2974633 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01015359001 2971817 2974633 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01015359001 2971817 2974633 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01015359001 2971817 2974633 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01015359001 2971817 2974633 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01015359001 2971817 2974633 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01015359001 2971817 2974633 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01015359001 2971817 2974633 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01015359001 2971817 2974633 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01015359001 2971817 2974633 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01015359001 2971817 2974633 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01015359001 2971817 2974633 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01015359001 2971817 2974633 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01015359001 2971817 2974633 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01015359001 2971817 2974633 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01015359001 2971817 2974633 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01015359001 2971817 2974633 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01015359001 2971817 2974633 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01015359001 2971817 2974633 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01015359001 2971817 2974633 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01015359001 2971817 2974633 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01015359001 2971817 2974633 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01015359001 2971817 2974633 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01015359001 2971817 2974633 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01015359001 2971817 2974633 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01015359001 2971817 2974633 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01015359001 2971817 2974633 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01034633001 13671455 13671925 GSVIVG01026735001 5846729 5848439 GSVIVG01035974001 6665974 6668116 GSVIVG01008867001 2909150 2910931 GSVIVG01038017001 12662202 12662813 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01038017001 12662202 12662813 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01038017001 12662202 12662813 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01038017001 12662202 12662813 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01038017001 12662202 12662813 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01038017001 12662202 12662813 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01038017001 12662202 12662813 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01038017001 12662202 12662813 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01025600001 13704229 13711120 GSVIVG01016137001 19580414 19587903 GSVIVG01021304001 3756459 3758115 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01017198001 5257252 5268154 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01017198001 5257252 5268154 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017198001 5257252 5268154 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01017198001 5257252 5268154 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01001321001 5296956 5326061 Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01003658001 11855012 11856387 GSVIVG01034878001 15784878 15786089 GSVIVG01024084001 1252097 1255340 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01007333001 31413744 31415587 GSVIVG01031940001 5578028 5578995 GSVIVG01013977001 8352001 8367844 GSVIVG01034491001 20461678 20465965 GO:0006415 translational termination The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code). IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA A translation release factor that is specific for one or more particular termination codons; acts at the ribosomal A-site and require polypeptidyl-tRNA at the P-site. IEA GO:0016149 translation release factor activity, codon specific GSVIVG01029553001 21653466 21671950 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01029553001 21653466 21671950 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008150001 5315019 5318138 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01030364001 5029820 5030799 GSVIVG01022495001 3906843 3907205 GSVIVG01018447001 14986277 14992069 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with lysosphingolipid or lysophosphatidic acid to initiate a change in cell activity. IEA GO:0001619 lysosphingolipid and lysophosphatidic acid receptor activity GSVIVG01013561001 20911870 20913529 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01013561001 20911870 20913529 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01013565001 20962434 20963774 GSVIVG01012780001 23345966 23348947 GSVIVG01009737001 10874144 10879349 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0005839 proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. IEA Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. IEA GO:0004298 threonine-type endopeptidase activity GSVIVG01036547001 23295018 23298857 GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds. IEA GO:0015035 protein disulfide oxidoreductase activity GSVIVG01012985001 10652275 10716631 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01014288001 2328736 2354460 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035128001 1683017 1690188 GO:0006631 fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035128001 1683017 1690188 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035128001 1683017 1690188 GO:0006631 fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035128001 1683017 1690188 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035128001 1683017 1690188 GO:0006631 fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01035128001 1683017 1690188 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01035128001 1683017 1690188 GO:0006631 fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01035128001 1683017 1690188 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01009224001 6411758 6415993 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GSVIVG01032782001 806477 809493 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01026551001 21928994 21930032 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01026551001 21928994 21930032 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01026551001 21928994 21930032 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01026551001 21928994 21930032 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016782001 1317408 1323628 GSVIVG01011538001 12817478 12826831 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01011538001 12817478 12826831 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01011538001 12817478 12826831 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01011538001 12817478 12826831 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01000726001 222103 227988 GSVIVG01031714001 3717642 3718712 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01031714001 3717642 3718712 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01019709001 2624684 2626283 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01019709001 2624684 2626283 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029546001 21769589 21779189 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01029546001 21769589 21779189 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01029546001 21769589 21779189 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033180 proton-transporting V-type ATPase, V1 domain A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01029546001 21769589 21779189 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01029546001 21769589 21779189 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01029546001 21769589 21779189 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033180 proton-transporting V-type ATPase, V1 domain A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01029546001 21769589 21779189 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01029546001 21769589 21779189 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01029546001 21769589 21779189 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0033180 proton-transporting V-type ATPase, V1 domain A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01029546001 21769589 21779189 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01029546001 21769589 21779189 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01029546001 21769589 21779189 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033180 proton-transporting V-type ATPase, V1 domain A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01029546001 21769589 21779189 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01029546001 21769589 21779189 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01029546001 21769589 21779189 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033180 proton-transporting V-type ATPase, V1 domain A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01029546001 21769589 21779189 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01029546001 21769589 21779189 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01029546001 21769589 21779189 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0033180 proton-transporting V-type ATPase, V1 domain A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01029546001 21769589 21779189 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01029546001 21769589 21779189 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01029546001 21769589 21779189 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033180 proton-transporting V-type ATPase, V1 domain A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01029546001 21769589 21779189 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01029546001 21769589 21779189 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01029546001 21769589 21779189 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033180 proton-transporting V-type ATPase, V1 domain A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01029546001 21769589 21779189 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01029546001 21769589 21779189 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01029546001 21769589 21779189 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0033180 proton-transporting V-type ATPase, V1 domain A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01029546001 21769589 21779189 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01029546001 21769589 21779189 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01029546001 21769589 21779189 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033180 proton-transporting V-type ATPase, V1 domain A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01029546001 21769589 21779189 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01029546001 21769589 21779189 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01029546001 21769589 21779189 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033180 proton-transporting V-type ATPase, V1 domain A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01029546001 21769589 21779189 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01029546001 21769589 21779189 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01029546001 21769589 21779189 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0033180 proton-transporting V-type ATPase, V1 domain A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01029546001 21769589 21779189 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01029546001 21769589 21779189 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01029546001 21769589 21779189 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033180 proton-transporting V-type ATPase, V1 domain A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01029546001 21769589 21779189 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01029546001 21769589 21779189 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01029546001 21769589 21779189 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033180 proton-transporting V-type ATPase, V1 domain A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01029546001 21769589 21779189 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01029546001 21769589 21779189 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01029546001 21769589 21779189 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0033180 proton-transporting V-type ATPase, V1 domain A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01028176001 4422473 4424163 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01027344001 16210514 16229601 GSVIVG01002334001 34169552 34172397 GSVIVG01030581001 6884921 6885771 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01030581001 6884921 6885771 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01030581001 6884921 6885771 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01030581001 6884921 6885771 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01001130001 22861922 22863800 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01001130001 22861922 22863800 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01003245001 8272146 8273099 GSVIVG01012381001 281501 285434 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01011561001 6467603 6468781 GSVIVG01028165001 4336437 4338840 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA GSVIVG01028165001 4336437 4338840 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GSVIVG01023028001 16671797 16681215 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023028001 16671797 16681215 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023028001 16671797 16681215 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023028001 16671797 16681215 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023028001 16671797 16681215 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01023028001 16671797 16681215 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01023028001 16671797 16681215 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01023028001 16671797 16681215 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01023028001 16671797 16681215 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023028001 16671797 16681215 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023028001 16671797 16681215 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023028001 16671797 16681215 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023028001 16671797 16681215 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023028001 16671797 16681215 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023028001 16671797 16681215 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023028001 16671797 16681215 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023028001 16671797 16681215 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01023028001 16671797 16681215 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01023028001 16671797 16681215 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01023028001 16671797 16681215 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01029855001 472211 476877 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: 2 H2O2 = O2 + 2 H2O. IEA GO:0004096 catalase activity GSVIVG01029855001 472211 476877 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2 H2O2 = O2 + 2 H2O. IEA GO:0004096 catalase activity GSVIVG01029855001 472211 476877 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01029855001 472211 476877 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01029855001 472211 476877 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01029855001 472211 476877 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01019689001 2479858 2482925 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01017623001 2094223 2097169 GSVIVG01009421001 8205967 8217973 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01009421001 8205967 8217973 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01009421001 8205967 8217973 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01009421001 8205967 8217973 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01009421001 8205967 8217973 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01009421001 8205967 8217973 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01009421001 8205967 8217973 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009421001 8205967 8217973 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009421001 8205967 8217973 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01009421001 8205967 8217973 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01023688001 9327776 9351864 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004185 serine-type carboxypeptidase activity GSVIVG01032020001 23474793 23475558 GSVIVG01023476001 11291090 11294210 GSVIVG01021167001 2112286 2113434 GSVIVG01032622001 2128112 2138401 GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O. IEA GO:0004129 cytochrome-c oxidase activity GSVIVG01020312001 21505372 21505737 GSVIVG01027051001 18355042 18355643 GSVIVG01033934001 16603680 16607543 GSVIVG01018257001 12372089 12373023 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01028372001 6760619 6761954 GSVIVG01026969001 18940954 18942146 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01026969001 18940954 18942146 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01026969001 18940954 18942146 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01026969001 18940954 18942146 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01026969001 18940954 18942146 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01026969001 18940954 18942146 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01032730001 1207472 1209002 Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate. IEA GO:0008146 sulfotransferase activity GSVIVG01004471001 38722437 38722959 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01004471001 38722437 38722959 GO:0019295 coenzyme M biosynthetic process The chemical reactions and pathways resulting in the formation of coenzyme M (2-thioethansulfonate), a coenzyme involved in the utilization of methane by methanogenic prokaryotes. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008605001 467822 477779 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028911001 17625001 17630168 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01028911001 17625001 17630168 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013622001 1801932 1805675 GSVIVG01029760001 14331302 14334752 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01028964001 17026799 17029223 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01034700001 7973617 7982087 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01034700001 7973617 7982087 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01025990001 26196038 26212515 GSVIVG01024714001 7524249 7527514 GSVIVG01021243001 2920858 2921460 GSVIVG01007844001 8441137 8447388 GSVIVG01029661001 12661588 12663496 GO:0009772 photosynthetic electron transport in photosystem II Electrons move from the primary electron acceptor (Quinone, Q) through a chain of electron transport molecules in the thylakoid membrane until they reach the ultimate electron acceptor of Photosystem II, which is plastocyanin (PC). The electron is then passed to the P700 chlorophyll a molecules of the reaction centre of photosystem I. IEA GO:0030077 plasma membrane light-harvesting complex A plasma membrane protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center. Examples of this complex are found in bacterial species. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01029661001 12661588 12663496 GO:0019684 photosynthesis, light reaction The light reactions of photosynthesis, which take place in photosystems II and I. Light energy is harvested and used to power the transfer of electrons among a series of electron donors and acceptors. The final electron acceptor is NADP+, which is reduced to NADPH. NADPH generated from light reactions is used in sugar synthesis in dark reactions. Light reactions also generate a proton motive force across the thylakoid membrane, and the proton gradient is used to synthesize ATP. There are two chemical reactions involved in the light reactions: water oxidation in photosystem II, and NADP reduction in photosystem I. IEA GO:0030077 plasma membrane light-harvesting complex A plasma membrane protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center. Examples of this complex are found in bacterial species. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01024418001 2314603 2333068 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024418001 2314603 2333068 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01019625001 2040491 2040918 GSVIVG01009319001 7332606 7337314 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004185 serine-type carboxypeptidase activity GSVIVG01020793001 1916439 1923051 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01020793001 1916439 1923051 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020793001 1916439 1923051 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01013960001 7862637 7862855 GSVIVG01007971001 7060726 7066945 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01007971001 7060726 7066945 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end. IEA GO:0004527 exonuclease activity GSVIVG01025934001 27016036 27023669 GSVIVG01025843001 11307999 11312605 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01025843001 11307999 11312605 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01014470001 4190151 4190744 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014470001 4190151 4190744 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009851001 11778507 11781055 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01009851001 11778507 11781055 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01009851001 11778507 11781055 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01009851001 11778507 11781055 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01013340001 12338251 12364001 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033703001 18472901 18474970 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01009394001 7977194 7980354 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01009394001 7977194 7980354 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01009394001 7977194 7980354 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01009394001 7977194 7980354 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01009394001 7977194 7980354 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035350001 684294 687056 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01035350001 684294 687056 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01018466001 14692378 14695065 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01018466001 14692378 14695065 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01018466001 14692378 14695065 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01018466001 14692378 14695065 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01009849001 11764401 11773531 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01009849001 11764401 11773531 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01009849001 11764401 11773531 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01009849001 11764401 11773531 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01037988001 12080841 12082934 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01037988001 12080841 12082934 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01037988001 12080841 12082934 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01037988001 12080841 12082934 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033473001 20406504 20408855 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01033473001 20406504 20408855 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01033473001 20406504 20408855 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01033473001 20406504 20408855 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033473001 20406504 20408855 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033473001 20406504 20408855 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033473001 20406504 20408855 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01033473001 20406504 20408855 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01033473001 20406504 20408855 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01033473001 20406504 20408855 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01033473001 20406504 20408855 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01033473001 20406504 20408855 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01029830001 236988 254730 GSVIVG01018421001 9259833 9309376 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01018421001 9259833 9309376 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01018421001 9259833 9309376 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01018421001 9259833 9309376 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01029048001 11376715 11380856 Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01036194001 9222993 9223518 GSVIVG01019094001 16772358 16776281 GSVIVG01017558001 10527183 10533020 GSVIVG01003465001 10527489 10527638 GSVIVG01024216001 155824 159081 Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum. IEA GO:0003993 acid phosphatase activity GSVIVG01024216001 155824 159081 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01024216001 155824 159081 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01037853001 7098160 7099838 GSVIVG01011381001 29196604 29203917 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01011381001 29196604 29203917 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01011381001 29196604 29203917 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011381001 29196604 29203917 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011381001 29196604 29203917 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01011381001 29196604 29203917 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01011381001 29196604 29203917 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01011381001 29196604 29203917 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01011381001 29196604 29203917 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01011381001 29196604 29203917 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01036130001 20346712 20352628 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01036130001 20346712 20352628 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01036130001 20346712 20352628 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01036130001 20346712 20352628 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01036130001 20346712 20352628 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01036130001 20346712 20352628 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01036130001 20346712 20352628 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01036130001 20346712 20352628 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01036130001 20346712 20352628 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01036130001 20346712 20352628 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01036130001 20346712 20352628 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01036130001 20346712 20352628 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01019924001 4501194 4502162 GSVIVG01037674001 6732346 6747822 GO:0006298 mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037674001 6732346 6747822 GO:0006298 mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. IEA Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches. IEA GO:0030983 mismatched DNA binding GSVIVG01028321001 6142757 6144597 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01016018001 17396134 17396412 GSVIVG01015174001 1567287 1577661 GSVIVG01016701001 472103 473410 GSVIVG01032134001 22308830 22345503 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027108001 17822483 17824942 GSVIVG01034795001 21740707 21742565 GSVIVG01001768001 6347768 6348097 GSVIVG01024451001 2742528 2745605 GSVIVG01013236001 6421696 6433453 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01003377001 9558101 9561702 GSVIVG01037452001 13480676 13492144 GSVIVG01005192001 19018332 19022461 GSVIVG01014725001 9002001 9008545 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005267 potassium channel activity GSVIVG01014725001 9002001 9008545 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005267 potassium channel activity GSVIVG01010961001 2619326 2622316 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01006674001 27377714 27378045 GSVIVG01022027001 4148995 4154841 GSVIVG01026561001 21807685 21809320 GSVIVG01015481001 4078615 4082046 GSVIVG01013384001 813503 815618 GSVIVG01006443001 26030465 26037136 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01017211001 5453528 5458751 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP(out) + ADP(in) = ATP(in) + ADP(out). IEA GO:0005471 ATP:ADP antiporter activity GSVIVG01017211001 5453528 5458751 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01004602001 39194560 39197260 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033956001 16333968 16338164 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01033956001 16333968 16338164 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01033956001 16333968 16338164 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01033956001 16333968 16338164 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033956001 16333968 16338164 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016520001 3182601 3184550 GSVIVG01022868001 18567609 18570935 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01022868001 18567609 18570935 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01022868001 18567609 18570935 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01022868001 18567609 18570935 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006262001 24155921 24156007 GSVIVG01015088001 939506 945402 GSVIVG01015473001 3992754 4002921 GSVIVG01037491001 12766106 12771428 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01037491001 12766106 12771428 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01030470001 5931092 5935262 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01011971001 2508128 2516980 GSVIVG01000012001 2775388 2776822 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01032932001 24257572 24259523 GSVIVG01015130001 1287131 1288334 GSVIVG01000450001 8125120 8126503 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019559001 1610314 1615187 GSVIVG01005138001 18497626 18499100 GSVIVG01010611001 16062537 16066034 GSVIVG01034778001 21252633 21263505 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid. IEA GO:0008417 fucosyltransferase activity GSVIVG01034778001 21252633 21263505 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid. IEA GO:0008417 fucosyltransferase activity GSVIVG01034778001 21252633 21263505 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid. IEA GO:0008417 fucosyltransferase activity GSVIVG01034778001 21252633 21263505 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0032580 Golgi cisterna membrane The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex. IEA Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid. IEA GO:0008417 fucosyltransferase activity GSVIVG01034778001 21252633 21263505 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01034778001 21252633 21263505 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01034778001 21252633 21263505 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01034778001 21252633 21263505 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0032580 Golgi cisterna membrane The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01034778001 21252633 21263505 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01034778001 21252633 21263505 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01034778001 21252633 21263505 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01034778001 21252633 21263505 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0032580 Golgi cisterna membrane The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex. IEA Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01027985001 2997523 3006621 GO:0006298 mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027985001 2997523 3006621 GO:0006298 mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. IEA Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches. IEA GO:0030983 mismatched DNA binding GSVIVG01031408001 19001053 19004260 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01031408001 19001053 19004260 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01010948001 2742536 2747173 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01010948001 2742536 2747173 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01010948001 2742536 2747173 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01010948001 2742536 2747173 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028619001 10909964 10911621 GSVIVG01006498001 42349528 42350824 GSVIVG01003813001 356348 359724 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: bile acid(out) + Na+(out) = bile acid(in) + Na+(in). IEA GO:0008508 bile acid:sodium symporter activity GSVIVG01015424001 3539907 3550291 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015424001 3539907 3550291 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015424001 3539907 3550291 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01015424001 3539907 3550291 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01033821001 17461484 17462665 GSVIVG01020585001 3997203 3999226 GO:0006519 cellular amino acid and derivative metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01020585001 3997203 3999226 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01020585001 3997203 3999226 GO:0006519 cellular amino acid and derivative metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells. IEA Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. IEA GO:0008483 transaminase activity GSVIVG01020585001 3997203 3999226 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. IEA GO:0008483 transaminase activity GSVIVG01020585001 3997203 3999226 GO:0006519 cellular amino acid and derivative metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells. IEA Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). IEA GO:0016769 transferase activity, transferring nitrogenous groups GSVIVG01020585001 3997203 3999226 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). IEA GO:0016769 transferase activity, transferring nitrogenous groups GSVIVG01020585001 3997203 3999226 GO:0006519 cellular amino acid and derivative metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells. IEA Catalysis of the reaction: S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + methylthioadenosine. IEA GO:0016847 1-aminocyclopropane-1-carboxylate synthase activity GSVIVG01020585001 3997203 3999226 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + methylthioadenosine. IEA GO:0016847 1-aminocyclopropane-1-carboxylate synthase activity GSVIVG01020585001 3997203 3999226 GO:0006519 cellular amino acid and derivative metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01020585001 3997203 3999226 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01000553001 7171468 7178529 GSVIVG01026411001 23834850 23834978 GSVIVG01023109001 22461570 22477993 GO:0009072 aromatic amino acid family metabolic process The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033731001 18270757 18280508 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033731001 18270757 18280508 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033731001 18270757 18280508 GO:0009097 isoleucine biosynthetic process The chemical reactions and pathways resulting in the formation of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033731001 18270757 18280508 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the reaction: L-threonine = 2-oxobutanoate + NH3. IEA GO:0004794 L-threonine ammonia-lyase activity GSVIVG01033731001 18270757 18280508 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: L-threonine = 2-oxobutanoate + NH3. IEA GO:0004794 L-threonine ammonia-lyase activity GSVIVG01033731001 18270757 18280508 GO:0009097 isoleucine biosynthetic process The chemical reactions and pathways resulting in the formation of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid. IEA Catalysis of the reaction: L-threonine = 2-oxobutanoate + NH3. IEA GO:0004794 L-threonine ammonia-lyase activity GSVIVG01033731001 18270757 18280508 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01033731001 18270757 18280508 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01033731001 18270757 18280508 GO:0009097 isoleucine biosynthetic process The chemical reactions and pathways resulting in the formation of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01023963001 2109844 2121573 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01012003001 2281187 2282306 GSVIVG01005997001 24316787 24318805 GSVIVG01021724001 10098039 10101011 GSVIVG01009662001 10288253 10294905 GSVIVG01006045001 23471585 23474443 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01006045001 23471585 23474443 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01038348001 13362976 13365590 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01038348001 13362976 13365590 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01038348001 13362976 13365590 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01038348001 13362976 13365590 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021719001 9989397 9990678 GSVIVG01013499001 1936009 1936962 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01013499001 1936009 1936962 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01030588001 6936165 6946525 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051539 4 iron, 4 sulfur cluster binding GSVIVG01036850001 18019984 18028031 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01032027001 23398491 23402604 GSVIVG01024759001 7171014 7175876 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01024759001 7171014 7175876 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01024759001 7171014 7175876 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01024759001 7171014 7175876 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01036881001 18311223 18323244 GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA GSVIVG01005837001 22168463 22171517 GSVIVG01033137001 8256197 8282552 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033137001 8256197 8282552 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033137001 8256197 8282552 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033137001 8256197 8282552 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033137001 8256197 8282552 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01033137001 8256197 8282552 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01027652001 14632297 14635061 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the reaction: pectin + n H2O = n methanol + pectate. IEA GO:0030599 pectinesterase activity GSVIVG01027499001 16182893 16185511 GSVIVG01022673001 14478819 14480844 GSVIVG01014112001 496541 500699 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014112001 496541 500699 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014112001 496541 500699 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. IEA GO:0004969 histamine receptor activity GSVIVG01014112001 496541 500699 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. IEA GO:0004969 histamine receptor activity GSVIVG01014112001 496541 500699 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014112001 496541 500699 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009076001 4742538 4745017 Interacting selectively and non-covalently with a specific domain of a protein. IEA GO:0019904 protein domain specific binding GSVIVG01032501001 27931300 27931488 GSVIVG01021651001 8772052 8772588 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: 3-alpha(S)-strictosidine = tryptamine + secologanin. IEA GO:0016844 strictosidine synthase activity GSVIVG01001695001 14385809 14386706 GSVIVG01017465001 8835848 8836527 GSVIVG01027559001 15582323 15591909 GSVIVG01001290001 5062531 5074048 GO:0008202 steroid metabolic process The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. IEA GSVIVG01034941001 262046 271104 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01034941001 262046 271104 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01033429001 20788274 20789420 GSVIVG01024515001 9413380 9415970 GSVIVG01034729001 8532504 8542055 GSVIVG01010320001 19466227 19475589 GO:0006614 SRP-dependent cotranslational protein targeting to membrane The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. IEA GO:0048500 signal recognition particle A complex of protein and RNA which facilitates translocation of proteins across membranes. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01010320001 19466227 19475589 GO:0006614 SRP-dependent cotranslational protein targeting to membrane The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. IEA GO:0048500 signal recognition particle A complex of protein and RNA which facilitates translocation of proteins across membranes. IEA Interacting selectively and non-covalently with 7S RNA, the RNA component of the signal recognition particle (SRP). IEA GO:0008312 7S RNA binding GSVIVG01038234001 24529157 24533756 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01029083001 12188267 12188410 GSVIVG01017822001 3759485 3791485 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01017822001 3759485 3791485 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01017822001 3759485 3791485 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: 3-dehydroquinate = 3-dehydroshikimate + H2O. IEA GO:0003855 3-dehydroquinate dehydratase activity GSVIVG01017822001 3759485 3791485 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: 3-dehydroquinate = 3-dehydroshikimate + H2O. IEA GO:0003855 3-dehydroquinate dehydratase activity GSVIVG01017822001 3759485 3791485 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: shikimate + NADP+ = 5-dehydroshikimate + NADPH + H+. IEA GO:0004764 shikimate 5-dehydrogenase activity GSVIVG01017822001 3759485 3791485 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: shikimate + NADP+ = 5-dehydroshikimate + NADPH + H+. IEA GO:0004764 shikimate 5-dehydrogenase activity GSVIVG01017822001 3759485 3791485 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017822001 3759485 3791485 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017822001 3759485 3791485 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01017822001 3759485 3791485 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01003739001 7531329 7537302 GSVIVG01025514001 106476 108096 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01023954001 2202701 2207438 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01023954001 2202701 2207438 Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. IEA GO:0008171 O-methyltransferase activity GSVIVG01023954001 2202701 2207438 The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01012258001 46794 47258 GSVIVG01008184001 4921251 4931711 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01008184001 4921251 4931711 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01008184001 4921251 4931711 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01008184001 4921251 4931711 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025625001 13496706 13498417 GSVIVG01011433001 29617353 29620701 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01011433001 29617353 29620701 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01017695001 2701609 2715812 GSVIVG01024874001 6322453 6331093 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01024874001 6322453 6331093 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01024874001 6322453 6331093 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024874001 6322453 6331093 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016434001 3934957 3940429 Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. IEA GO:0005089 Rho guanyl-nucleotide exchange factor activity GSVIVG01014322001 2613231 2621035 GSVIVG01027619001 14999696 15021317 GSVIVG01019369001 252946 256302 GSVIVG01032038001 23295905 23301496 GO:0000228 nuclear chromosome A chromosome found in the nucleus of a eukaryotic cell. IEA GSVIVG01019982001 12006749 12014396 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01033341001 21357231 21358071 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01033341001 21357231 21358071 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01023840001 3056278 3059289 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01023840001 3056278 3059289 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01023840001 3056278 3059289 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01023840001 3056278 3059289 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01023840001 3056278 3059289 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01023840001 3056278 3059289 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01038128001 23693567 23695945 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01038128001 23693567 23695945 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01028038001 3351619 3352410 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01028038001 3351619 3352410 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01021119001 1625051 1626049 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01021119001 1625051 1626049 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01021119001 1625051 1626049 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01021119001 1625051 1626049 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033501001 20217445 20219575 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01033501001 20217445 20219575 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01033501001 20217445 20219575 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01033501001 20217445 20219575 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01033501001 20217445 20219575 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033501001 20217445 20219575 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008363001 2871428 2872600 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01008363001 2871428 2872600 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01008363001 2871428 2872600 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008363001 2871428 2872600 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008363001 2871428 2872600 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01008363001 2871428 2872600 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01030611001 7162998 7166130 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. IEA GO:0003743 translation initiation factor activity GSVIVG01030611001 7162998 7166130 GO:0006413 translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. IEA Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. IEA GO:0003743 translation initiation factor activity GSVIVG01024789001 6937301 6942751 GO:0009228 thiamin biosynthetic process The chemical reactions and pathways resulting in the formation of thiamin (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver. IEA GSVIVG01001833001 26184035 26186471 GSVIVG01011981001 2429294 2433043 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01011981001 2429294 2433043 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011981001 2429294 2433043 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01011981001 2429294 2433043 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01000503001 15137462 15139011 GSVIVG01030943001 19549560 19555471 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01030441001 5574793 5578484 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01030441001 5574793 5578484 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01007122001 30184885 30188758 GSVIVG01015393001 3249494 3250798 GSVIVG01012311001 13425714 13425944 GSVIVG01029846001 345582 355530 GSVIVG01038159001 23990713 23991618 GO:0006631 fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01038159001 23990713 23991618 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01038159001 23990713 23991618 GO:0006631 fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. IEA Catalysis of the reaction: stearoyl-[acyl-carrier protein] + reduced acceptor + O2 = oleoyl-[acyl-carrier protein] + acceptor + H2O. The enzyme requires ferredoxin. IEA GO:0045300 acyl-[acyl-carrier-protein] desaturase activity GSVIVG01038159001 23990713 23991618 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: stearoyl-[acyl-carrier protein] + reduced acceptor + O2 = oleoyl-[acyl-carrier protein] + acceptor + H2O. The enzyme requires ferredoxin. IEA GO:0045300 acyl-[acyl-carrier-protein] desaturase activity GSVIVG01038159001 23990713 23991618 GO:0006631 fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01038159001 23990713 23991618 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01014854001 10665036 10669055 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01014854001 10665036 10669055 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01010578001 16411731 16413395 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010578001 16411731 16413395 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010578001 16411731 16413395 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01010578001 16411731 16413395 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01022367001 19106768 19130673 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022367001 19106768 19130673 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01024031001 1640991 1645417 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0009341 beta-galactosidase complex A multimeric enzyme complex that in E. coli is a heterooctamer made up of four alpha subunits and four beta subunits. Catalyzes the hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024031001 1640991 1645417 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0009341 beta-galactosidase complex A multimeric enzyme complex that in E. coli is a heterooctamer made up of four alpha subunits and four beta subunits. Catalyzes the hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01024031001 1640991 1645417 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0009341 beta-galactosidase complex A multimeric enzyme complex that in E. coli is a heterooctamer made up of four alpha subunits and four beta subunits. Catalyzes the hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides. IEA Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides. IEA GO:0004565 beta-galactosidase activity GSVIVG01024031001 1640991 1645417 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0009341 beta-galactosidase complex A multimeric enzyme complex that in E. coli is a heterooctamer made up of four alpha subunits and four beta subunits. Catalyzes the hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01024031001 1640991 1645417 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0009341 beta-galactosidase complex A multimeric enzyme complex that in E. coli is a heterooctamer made up of four alpha subunits and four beta subunits. Catalyzes the hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01017991001 5310890 5316248 GSVIVG01011960001 2606152 2608392 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01025604001 13683616 13684753 GSVIVG01011859001 3517780 3520132 GSVIVG01022111001 16661373 16668053 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01016273001 5614859 5625575 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01016273001 5614859 5625575 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01016273001 5614859 5625575 Interacting selectively and non-covalently with manganese (Mn) ions. IEA GO:0030145 manganese ion binding GSVIVG01038481001 10150394 10151378 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01011700001 4989641 5011798 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01011700001 4989641 5011798 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the transfer of a phosphate group from one position to another within a single molecule. IEA GO:0016868 intramolecular transferase activity, phosphotransferases GSVIVG01031195001 1282304 1289551 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025977001 26399782 26401436 GSVIVG01008720001 1446641 1449144 GSVIVG01000122001 15426936 15432003 GO:0006820 anion transport The directed movement of anions, atoms or small molecules with a net negative charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005741 mitochondrial outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope. IEA Catalysis of the transmembrane transfer of an anion by a voltage-gated channel. An anion is a negatively charged ion. IEA GO:0008308 voltage-gated anion channel activity GSVIVG01000122001 15426936 15432003 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005741 mitochondrial outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope. IEA Catalysis of the transmembrane transfer of an anion by a voltage-gated channel. An anion is a negatively charged ion. IEA GO:0008308 voltage-gated anion channel activity GSVIVG01025143001 4002408 4013052 GSVIVG01001783001 3068050 3070405 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01001783001 3068050 3070405 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01001783001 3068050 3070405 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01033458001 20515947 20516976 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01036355001 4144541 4150911 GSVIVG01030605001 7101002 7106874 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01030605001 7101002 7106874 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01030605001 7101002 7106874 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01030605001 7101002 7106874 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01030605001 7101002 7106874 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01030605001 7101002 7106874 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01030605001 7101002 7106874 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01030605001 7101002 7106874 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01019794001 3352541 3353184 GSVIVG01030099001 9804269 9811886 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01030099001 9804269 9811886 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009551001 9313562 9332778 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01009551001 9313562 9332778 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01009551001 9313562 9332778 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01003096001 8637799 8658367 GO:0007205 activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway The initiation of the activity of the inactive enzyme protein kinase C as the result of a series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol 3-phosphate. IEA GO:0004143 diacylglycerol kinase activity GSVIVG01008926001 3432983 3445082 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01008926001 3432983 3445082 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01008926001 3432983 3445082 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01008926001 3432983 3445082 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020422001 19655290 19660706 GSVIVG01021825001 6812186 6867055 GSVIVG01023438001 11938528 11942000 GSVIVG01024441001 2612661 2625514 GSVIVG01012187001 710556 714160 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012187001 710556 714160 Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01037164001 28417918 28419222 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01037164001 28417918 28419222 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01025734001 12481890 12484073 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01031704001 3587104 3588547 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01027833001 8339150 8359048 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01027833001 8339150 8359048 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01027833001 8339150 8359048 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01027833001 8339150 8359048 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01027833001 8339150 8359048 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027833001 8339150 8359048 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01027833001 8339150 8359048 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01015023001 528067 530450 GSVIVG01031252001 788614 789198 GSVIVG01012347001 805166 807275 GSVIVG01009461001 8549863 8563296 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01009461001 8549863 8563296 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular peptide to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state. IEA GO:0008528 peptide receptor activity, G-protein coupled GSVIVG01019047001 17388144 17391078 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019047001 17388144 17391078 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01009730001 10838352 10839671 GSVIVG01028357001 6526860 6539177 GO:0018279 protein amino acid N-linked glycosylation via asparagine The posttranslational glycosylation of protein via the N4 atom of peptidyl-asparagine forming N4-glycosyl-L-asparagine; the most common form is N-acetylglucosaminyl asparagine; N-acetylgalactosaminyl asparagine also occurs; this modification typically occurs in extracellular peptides with an N-X-(ST) motif. Partial modification has been observed to occur with cysteine, rather than serine or threonine, in the third position; secondary structure features are important, and proline in the second or fourth positions inhibits modification. IEA GO:0005789 endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum. IEA Catalysis of the reaction: dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by glycosylamine linkage to protein L-asparagine. IEA GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity GSVIVG01028357001 6526860 6539177 GO:0018279 protein amino acid N-linked glycosylation via asparagine The posttranslational glycosylation of protein via the N4 atom of peptidyl-asparagine forming N4-glycosyl-L-asparagine; the most common form is N-acetylglucosaminyl asparagine; N-acetylgalactosaminyl asparagine also occurs; this modification typically occurs in extracellular peptides with an N-X-(ST) motif. Partial modification has been observed to occur with cysteine, rather than serine or threonine, in the third position; secondary structure features are important, and proline in the second or fourth positions inhibits modification. IEA GO:0008250 oligosaccharyltransferase complex A protein complex that is found in the endoplasmic reticulum membrane of eukaryotes and transfers lipid-linked oligosaccharide precursor to asparagine residues on nascent proteins. In yeast, the complex includes at least nine different subunits, whereas in mammalian cells at least three different forms of the complex have been detected. IEA Catalysis of the reaction: dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by glycosylamine linkage to protein L-asparagine. IEA GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity GSVIVG01017543001 10283284 10288804 GSVIVG01003692001 12254860 12255202 GSVIVG01001014001 20023875 20024809 GSVIVG01012486001 13745873 13755481 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01012486001 13745873 13755481 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012486001 13745873 13755481 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription. IEA GO:0008134 transcription factor binding GSVIVG01012486001 13745873 13755481 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01012486001 13745873 13755481 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01012455001 1118281 1120301 GSVIVG01029030001 10938188 10941512 GSVIVG01007473001 32150801 32152120 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: 3-alpha(S)-strictosidine = tryptamine + secologanin. IEA GO:0016844 strictosidine synthase activity GSVIVG01037800001 7813667 7818295 GSVIVG01034803001 21844611 21844960 GSVIVG01008097001 5809177 5813070 GSVIVG01009082001 4791465 4794870 GSVIVG01008440001 2042323 2043706 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01034532001 19797743 19801223 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01034532001 19797743 19801223 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01034532001 19797743 19801223 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01034532001 19797743 19801223 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01034532001 19797743 19801223 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01034532001 19797743 19801223 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01031734001 3907433 3915967 GSVIVG01021393001 4865119 4867607 GSVIVG01026667001 4555530 4556089 GSVIVG01029723001 13762928 13764165 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GSVIVG01003943001 8239682 8240845 GSVIVG01017213001 5499349 5499556 GSVIVG01034560001 19466090 19471788 GSVIVG01037263001 16763794 16765563 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027410001 16940880 16945845 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA GSVIVG01007740001 9703426 9704372 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025168001 3794139 3802520 GSVIVG01002375001 34449874 34454632 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01002375001 34449874 34454632 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01002375001 34449874 34454632 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01002375001 34449874 34454632 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01025358001 1563246 1568948 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025358001 1563246 1568948 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025358001 1563246 1568948 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025358001 1563246 1568948 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Catalysis of the reaction: acyl-[acyl-carrier protein] + NAD+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+. IEA GO:0004318 enoyl-[acyl-carrier-protein] reductase (NADH) activity GSVIVG01025358001 1563246 1568948 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: acyl-[acyl-carrier protein] + NAD+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+. IEA GO:0004318 enoyl-[acyl-carrier-protein] reductase (NADH) activity GSVIVG01025358001 1563246 1568948 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: acyl-[acyl-carrier protein] + NAD+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+. IEA GO:0004318 enoyl-[acyl-carrier-protein] reductase (NADH) activity GSVIVG01025358001 1563246 1568948 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025358001 1563246 1568948 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025358001 1563246 1568948 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025358001 1563246 1568948 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025358001 1563246 1568948 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025358001 1563246 1568948 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01035686001 3333796 3334424 GSVIVG01024854001 6468016 6471011 GSVIVG01013726001 8170604 8175052 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01003971001 26400813 26407428 GSVIVG01011163001 7570995 7572928 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01016189001 6884838 6892692 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004185 serine-type carboxypeptidase activity GSVIVG01035178001 12865608 12869140 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033763001 18037979 18040088 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01033763001 18037979 18040088 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01033763001 18037979 18040088 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01033763001 18037979 18040088 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01001377001 24098843 24100253 GSVIVG01006892001 28915840 28918772 GSVIVG01002332001 34161697 34167622 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01002332001 34161697 34167622 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01002332001 34161697 34167622 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01002332001 34161697 34167622 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025309001 2201086 2202854 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01025309001 2201086 2202854 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01025309001 2201086 2202854 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01025309001 2201086 2202854 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01004818001 157052 158379 GSVIVG01001529001 1041468 1046204 GSVIVG01008844001 2734587 2737586 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01029220001 18377334 18384816 GSVIVG01013617001 1675518 1682503 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of potassium ions (K+) from one side of a membrane to the other. IEA GO:0015079 potassium ion transmembrane transporter activity GSVIVG01024121001 918671 922108 GSVIVG01019969001 12212093 12215480 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019969001 12212093 12215480 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008015001 6668795 6671476 GSVIVG01015380001 3138626 3143400 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01000351001 11895010 11895610 GSVIVG01013799001 7469367 7474277 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01013799001 7469367 7474277 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01013799001 7469367 7474277 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01013799001 7469367 7474277 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029432001 22970640 22991938 GSVIVG01018981001 18116506 18126495 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01018981001 18116506 18126495 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01029171001 18957733 18958954 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01029171001 18957733 18958954 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01029171001 18957733 18958954 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01029171001 18957733 18958954 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01029171001 18957733 18958954 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01029171001 18957733 18958954 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01029171001 18957733 18958954 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01029171001 18957733 18958954 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01019621001 2016486 2019135 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01009149001 5539753 5544866 GSVIVG01016840001 1857004 1858110 GSVIVG01033133001 8186337 8201310 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033133001 8186337 8201310 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033133001 8186337 8201310 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033133001 8186337 8201310 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033133001 8186337 8201310 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01033133001 8186337 8201310 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01033779001 17884683 17902051 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01033779001 17884683 17902051 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01033779001 17884683 17902051 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01033779001 17884683 17902051 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038643001 21255005 21256990 GO:0044238 primary metabolic process The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026348001 14527354 14529566 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01026348001 14527354 14529566 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01017918001 4651064 4670328 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01017918001 4651064 4670328 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01035817001 4590126 4595121 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01014044001 9935936 9941669 GSVIVG01030557001 6707557 6709533 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008374001 2707209 2720616 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. IEA GO:0004364 glutathione transferase activity GSVIVG01020171001 9454040 9455898 GSVIVG01000723001 186113 192116 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000723001 186113 192116 Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01014894001 11317430 11332874 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01014894001 11317430 11332874 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01014894001 11317430 11332874 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01014894001 11317430 11332874 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01038420001 12047634 12047798 GSVIVG01003216001 13988502 14007397 GSVIVG01035161001 12442335 12449324 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035161001 12442335 12449324 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nucleotidyl group to a reactant. IEA GO:0016779 nucleotidyltransferase activity GSVIVG01032875001 64796 72635 GSVIVG01001550001 1446107 1446905 GSVIVG01026163001 13244487 13245775 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005839 proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. IEA Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. IEA GO:0004298 threonine-type endopeptidase activity GSVIVG01026163001 13244487 13245775 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. IEA GO:0004298 threonine-type endopeptidase activity GSVIVG01026163001 13244487 13245775 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0005839 proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. IEA Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. IEA GO:0004298 threonine-type endopeptidase activity GSVIVG01026163001 13244487 13245775 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. IEA GO:0004298 threonine-type endopeptidase activity GSVIVG01026163001 13244487 13245775 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005839 proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. IEA Catalysis of the reaction: diphosphate + H2O = 2 phosphate. IEA GO:0004427 inorganic diphosphatase activity GSVIVG01026163001 13244487 13245775 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: diphosphate + H2O = 2 phosphate. IEA GO:0004427 inorganic diphosphatase activity GSVIVG01026163001 13244487 13245775 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0005839 proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. IEA Catalysis of the reaction: diphosphate + H2O = 2 phosphate. IEA GO:0004427 inorganic diphosphatase activity GSVIVG01026163001 13244487 13245775 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: diphosphate + H2O = 2 phosphate. IEA GO:0004427 inorganic diphosphatase activity GSVIVG01026163001 13244487 13245775 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005839 proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. IEA Catalysis of the hydrolysis of pyrophosphate, which generates a proton motive force. IEA GO:0009678 hydrogen-translocating pyrophosphatase activity GSVIVG01026163001 13244487 13245775 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of pyrophosphate, which generates a proton motive force. IEA GO:0009678 hydrogen-translocating pyrophosphatase activity GSVIVG01026163001 13244487 13245775 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0005839 proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. IEA Catalysis of the hydrolysis of pyrophosphate, which generates a proton motive force. IEA GO:0009678 hydrogen-translocating pyrophosphatase activity GSVIVG01026163001 13244487 13245775 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of pyrophosphate, which generates a proton motive force. IEA GO:0009678 hydrogen-translocating pyrophosphatase activity GSVIVG01019125001 16523401 16527061 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01028929001 17357370 17397188 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01006083001 41242961 41245076 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01027351001 16003387 16007439 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01027351001 16003387 16007439 The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01011651001 5592959 5593891 GSVIVG01025540001 14198022 14201325 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025540001 14198022 14201325 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025540001 14198022 14201325 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025540001 14198022 14201325 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025540001 14198022 14201325 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. IEA GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity GSVIVG01025540001 14198022 14201325 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. IEA GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity GSVIVG01025540001 14198022 14201325 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025540001 14198022 14201325 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017309001 6610696 6619481 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01017309001 6610696 6619481 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01012394001 378484 380883 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012394001 378484 380883 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012394001 378484 380883 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01012394001 378484 380883 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01012394001 378484 380883 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01012394001 378484 380883 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01032414001 27139003 27145873 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01032414001 27139003 27145873 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01032414001 27139003 27145873 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01032414001 27139003 27145873 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030736001 14808365 14808988 GSVIVG01002500001 35076076 35082225 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029415001 16976054 16982389 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. IEA GO:0003743 translation initiation factor activity GSVIVG01029415001 16976054 16982389 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. IEA GO:0003743 translation initiation factor activity GSVIVG01029415001 16976054 16982389 GO:0006413 translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. IEA Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. IEA GO:0003743 translation initiation factor activity GSVIVG01029415001 16976054 16982389 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. IEA GO:0003743 translation initiation factor activity GSVIVG01029415001 16976054 16982389 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029415001 16976054 16982389 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029415001 16976054 16982389 GO:0006413 translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029415001 16976054 16982389 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029415001 16976054 16982389 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01029415001 16976054 16982389 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01029415001 16976054 16982389 GO:0006413 translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01029415001 16976054 16982389 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01029415001 16976054 16982389 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01029415001 16976054 16982389 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01029415001 16976054 16982389 GO:0006413 translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01029415001 16976054 16982389 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01003555001 14606893 14611837 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01003555001 14606893 14611837 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01003555001 14606893 14611837 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003555001 14606893 14611837 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003555001 14606893 14611837 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01003555001 14606893 14611837 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01033861001 17180440 17181362 GSVIVG01014225001 1660410 1665583 GSVIVG01027440001 16699400 16704472 GSVIVG01007124001 30204348 30205134 GSVIVG01009490001 8810965 8814646 GSVIVG01016847001 1902966 1916128 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01016847001 1902966 1916128 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01016847001 1902966 1916128 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016847001 1902966 1916128 Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01001223001 1459686 1461202 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01001223001 1459686 1461202 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01013998001 8701375 8703294 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01013417001 599936 601322 GSVIVG01004850001 49937 53027 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01032741001 1107276 1138054 GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01004075001 14568884 14571901 GSVIVG01023910001 2528389 2528867 GSVIVG01021973001 4855160 4862890 GSVIVG01031119001 2017360 2018190 GO:0051260 protein homooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01020131001 10044523 10046730 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01020131001 10044523 10046730 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01020131001 10044523 10046730 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01020131001 10044523 10046730 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020619001 3698087 3699569 Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. IEA GO:0008171 O-methyltransferase activity GSVIVG01012644001 315173 317435 GO:0006568 tryptophan metabolic process The chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012644001 315173 317435 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012644001 315173 317435 GO:0006568 tryptophan metabolic process The chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid. IEA Catalysis of the reaction: L-serine + 1-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H2O. IEA GO:0004834 tryptophan synthase activity GSVIVG01012644001 315173 317435 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: L-serine + 1-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H2O. IEA GO:0004834 tryptophan synthase activity GSVIVG01012644001 315173 317435 GO:0006568 tryptophan metabolic process The chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01012644001 315173 317435 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01004948001 16913692 16914998 GSVIVG01022032001 4086918 4090600 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01000818001 561908 589861 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01001872001 6517126 6518157 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01001872001 6517126 6518157 Catalysis of the reaction: ATP + shikimate = ADP + shikimate 3-phosphate. IEA GO:0004765 shikimate kinase activity GSVIVG01001872001 6517126 6518157 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001872001 6517126 6518157 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01017876001 4221453 4226424 GSVIVG01031312001 456872 466070 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01031312001 456872 466070 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01031312001 456872 466070 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01031312001 456872 466070 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01000570001 6977775 6982566 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000570001 6977775 6982566 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01015956001 16128196 16160750 GO:0006644 phospholipid metabolic process The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester. IEA Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule. IEA GO:0008170 N-methyltransferase activity GSVIVG01012721001 964308 971082 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid. IEA GO:0008378 galactosyltransferase activity GSVIVG01012044001 1839816 1883645 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012044001 1839816 1883645 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012044001 1839816 1883645 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008238001 4274453 4277479 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008238001 4274453 4277479 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008238001 4274453 4277479 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008238001 4274453 4277479 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008238001 4274453 4277479 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01008238001 4274453 4277479 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01031842001 4804014 4809985 GSVIVG01015282001 2371104 2375298 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015282001 2371104 2375298 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01015282001 2371104 2375298 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01010232001 18012152 18020938 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01010232001 18012152 18020938 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds. IEA GO:0015035 protein disulfide oxidoreductase activity GSVIVG01025353001 1589297 1606549 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01022015001 4289795 4291828 GO:0006614 SRP-dependent cotranslational protein targeting to membrane The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01022015001 4289795 4291828 GO:0006614 SRP-dependent cotranslational protein targeting to membrane The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01018957001 18370563 18382064 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01019935001 4597637 4600917 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. IEA GO:0016597 amino acid binding GSVIVG01012862001 6322268 6327957 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01020065001 10863424 10880276 GSVIVG01009775001 11175010 11180097 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GSVIVG01036936001 17330098 17381317 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01036936001 17330098 17381317 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01036936001 17330098 17381317 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01036936001 17330098 17381317 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036936001 17330098 17381317 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008640001 201292 212911 GO:0032312 regulation of ARF GTPase activity Any process that modulates the activity of the GTPase ARF. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01008640001 201292 212911 GO:0032312 regulation of ARF GTPase activity Any process that modulates the activity of the GTPase ARF. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Increases the rate of GTP hydrolysis by the GTPase ARF. IEA GO:0008060 ARF GTPase activator activity GSVIVG01008640001 201292 212911 GO:0032312 regulation of ARF GTPase activity Any process that modulates the activity of the GTPase ARF. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01034544001 19628751 19649753 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01034544001 19628751 19649753 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01034544001 19628751 19649753 GO:0030259 lipid glycosylation Covalent attachment of a glycosyl residue to a lipid molecule. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01020289001 21850794 21853319 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01015624001 14249408 14249473 GSVIVG01014873001 11020046 11020558 GSVIVG01024378001 1762632 1765497 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01024378001 1762632 1765497 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01019631001 2100594 2102056 GSVIVG01000069001 3208547 3209619 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with manganese (Mn) ions. IEA GO:0030145 manganese ion binding GSVIVG01000069001 3208547 3209619 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Functions in the storage of nutritious substrates. IEA GO:0045735 nutrient reservoir activity GSVIVG01011984001 2410021 2422646 GSVIVG01016176001 7050995 7055397 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01001435001 20954941 20967561 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004185 serine-type carboxypeptidase activity GSVIVG01037627001 6342763 6345353 GSVIVG01016811001 1586756 1589503 GO:0006499 N-terminal protein myristoylation The covalent or non-covalent attachment of a myristoyl moiety to the N-terminal amino acid residue of a protein. IEA Catalysis of the reaction: tetradecanoyl-CoA + glycyl-peptide = CoA + N-tetradecanoylglycyl-peptide. IEA GO:0004379 glycylpeptide N-tetradecanoyltransferase activity GSVIVG01028825001 18328789 18337702 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01028825001 18328789 18337702 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01031636001 19303220 19374596 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01031636001 19303220 19374596 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01031636001 19303220 19374596 GO:0006268 DNA unwinding involved in replication The process by which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01031636001 19303220 19374596 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01031636001 19303220 19374596 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01031636001 19303220 19374596 GO:0006268 DNA unwinding involved in replication The process by which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01031636001 19303220 19374596 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA. IEA GO:0003916 DNA topoisomerase activity GSVIVG01031636001 19303220 19374596 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA. IEA GO:0003916 DNA topoisomerase activity GSVIVG01031636001 19303220 19374596 GO:0006268 DNA unwinding involved in replication The process by which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA. IEA GO:0003916 DNA topoisomerase activity GSVIVG01031636001 19303220 19374596 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle. IEA GO:0003917 DNA topoisomerase type I activity GSVIVG01031636001 19303220 19374596 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle. IEA GO:0003917 DNA topoisomerase type I activity GSVIVG01031636001 19303220 19374596 GO:0006268 DNA unwinding involved in replication The process by which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle. IEA GO:0003917 DNA topoisomerase type I activity GSVIVG01022242001 17780029 17780654 Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01022242001 17780029 17780654 Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01022242001 17780029 17780654 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01022242001 17780029 17780654 Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01023547001 9852816 9853055 GSVIVG01019605001 1885294 1889123 GO:0000272 polysaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019605001 1885294 1889123 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019605001 1885294 1889123 GO:0000272 polysaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages. IEA Catalysis of the hydrolysis of 1,4-alpha-glucosidic linkages in polysaccharides so as to remove successive maltose units from the non-reducing ends of the chains. IEA GO:0016161 beta-amylase activity GSVIVG01019605001 1885294 1889123 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of 1,4-alpha-glucosidic linkages in polysaccharides so as to remove successive maltose units from the non-reducing ends of the chains. IEA GO:0016161 beta-amylase activity GSVIVG01019605001 1885294 1889123 GO:0000272 polysaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01019605001 1885294 1889123 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01020824001 1514071 1514724 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020824001 1514071 1514724 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020824001 1514071 1514724 Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01020824001 1514071 1514724 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01033556001 19773543 19778963 GO:0006415 translational termination The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code). IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Involved in catalyzing the release of a nascent polypeptide chain from a ribosome. IEA GO:0003747 translation release factor activity GSVIVG01033556001 19773543 19778963 GO:0006415 translational termination The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code). IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA A translation release factor that is specific for one or more particular termination codons; acts at the ribosomal A-site and require polypeptidyl-tRNA at the P-site. IEA GO:0016149 translation release factor activity, codon specific GSVIVG01023798001 3404384 3408097 GSVIVG01004004001 14253563 14257187 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01004004001 14253563 14257187 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01004004001 14253563 14257187 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01004004001 14253563 14257187 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01004004001 14253563 14257187 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001167001 1117072 1120196 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01001167001 1117072 1120196 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01001167001 1117072 1120196 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01001167001 1117072 1120196 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01001167001 1117072 1120196 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01001167001 1117072 1120196 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01033705001 18465212 18467336 GO:0015931 nucleobase, nucleoside, nucleotide and nucleic acid transport The directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acidfrom one side of a membrane to the other. IEA GO:0015205 nucleobase transmembrane transporter activity GSVIVG01033705001 18465212 18467336 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acidfrom one side of a membrane to the other. IEA GO:0015205 nucleobase transmembrane transporter activity GSVIVG01031598001 18718170 18750726 GSVIVG01008921001 3401893 3411202 GSVIVG01032987001 24882602 24885510 GSVIVG01017870001 4177158 4180017 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017870001 4177158 4180017 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017870001 4177158 4180017 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01017870001 4177158 4180017 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01021512001 6430623 6433838 GSVIVG01008825001 2496618 2503398 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005663 DNA replication factor C complex A complex of five polypeptides in eukaryotes, and two in prokaryotes, that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01008825001 2496618 2503398 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005663 DNA replication factor C complex A complex of five polypeptides in eukaryotes, and two in prokaryotes, that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01008825001 2496618 2503398 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005663 DNA replication factor C complex A complex of five polypeptides in eukaryotes, and two in prokaryotes, that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their closing around the DNA duplex. IEA GO:0003689 DNA clamp loader activity GSVIVG01008825001 2496618 2503398 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005663 DNA replication factor C complex A complex of five polypeptides in eukaryotes, and two in prokaryotes, that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008825001 2496618 2503398 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005663 DNA replication factor C complex A complex of five polypeptides in eukaryotes, and two in prokaryotes, that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01002635001 35558410 35560465 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. IEA GO:0005516 calmodulin binding GSVIVG01002635001 35558410 35560465 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01031290001 588113 593075 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01017005001 3396960 3397982 GSVIVG01017836001 3900557 3903993 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01035025001 982886 985406 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01011997001 2339822 2340254 GSVIVG01003765001 12486013 12503228 GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA GSVIVG01024630001 8249119 8253061 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01024630001 8249119 8253061 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01037520001 12309298 12319547 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01000421001 7749616 7750707 GSVIVG01028632001 11264351 11273150 GO:0006120 mitochondrial electron transport, NADH to ubiquinone The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex I. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028632001 11264351 11273150 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028632001 11264351 11273150 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028632001 11264351 11273150 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028632001 11264351 11273150 GO:0006120 mitochondrial electron transport, NADH to ubiquinone The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex I. IEA Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. IEA GO:0008137 NADH dehydrogenase (ubiquinone) activity GSVIVG01028632001 11264351 11273150 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. IEA GO:0008137 NADH dehydrogenase (ubiquinone) activity GSVIVG01028632001 11264351 11273150 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. IEA GO:0008137 NADH dehydrogenase (ubiquinone) activity GSVIVG01028632001 11264351 11273150 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. IEA GO:0008137 NADH dehydrogenase (ubiquinone) activity GSVIVG01022354001 18930438 18932497 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035997001 6981231 6982155 GSVIVG01033820001 17474437 17477988 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GSVIVG01035834001 4758787 4759438 GSVIVG01001697001 12199843 12207930 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01001697001 12199843 12207930 Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01020557001 4390938 4406316 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01020557001 4390938 4406316 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01020557001 4390938 4406316 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01020557001 4390938 4406316 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01020557001 4390938 4406316 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020557001 4390938 4406316 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014172001 1082309 1086930 GSVIVG01027432001 16779787 16780362 GSVIVG01035748001 3875333 3885838 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01035748001 3875333 3885838 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01035748001 3875333 3885838 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01035748001 3875333 3885838 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01035748001 3875333 3885838 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01035748001 3875333 3885838 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01033432001 20728208 20735141 GSVIVG01006710001 27689948 27695280 GSVIVG01014842001 10465711 10466295 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009522 photosystem I A photosystem that contains an iron-sulfur reaction center associated with accessory pigments and electron carriers. In cyanobacteria and chloroplasts, photosystem I functions as a light-dependent plastocyanin-ferredoxin oxidoreductase, transferring electrons from plastocyanin to ferredoxin; in photosynthetic bacteria that have only a single type I photosystem, such as the green sulfur bacteria, electrons can go either to ferredoxin (Fd) -> NAD+ or to menaquinone (MK) -> Cytb/FeS -> Cytc555 -> photosystem I (cyclic photophosphorylation). IEA GSVIVG01014842001 10465711 10466295 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01034315001 14754861 14772206 GSVIVG01010017001 13493089 13494429 GSVIVG01014799001 9933098 9933415 Interacting selectively and non-covalently with thiamin pyrophosphate, the diphosphoric ester of thiamin. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases. IEA GO:0030976 thiamin pyrophosphate binding GSVIVG01013979001 8378573 8402273 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025373001 1263824 1274454 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01025373001 1263824 1274454 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01025373001 1263824 1274454 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01025373001 1263824 1274454 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01025373001 1263824 1274454 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025373001 1263824 1274454 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025373001 1263824 1274454 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01025373001 1263824 1274454 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01025373001 1263824 1274454 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01025373001 1263824 1274454 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01028292001 5798598 5813156 GSVIVG01010088001 15211274 15212244 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01010088001 15211274 15212244 Catalysis of the two-stage endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides with 2',3'-cyclic phosphate intermediates. IEA GO:0033897 ribonuclease T2 activity GSVIVG01027529001 15965410 15970076 GO:0000154 rRNA modification The covalent alteration of one or more nucleotides within an rRNA molecule to produce an rRNA molecule with a sequence that differs from that coded genetically. IEA Catalysis of the dimethylation two adjacent A residues in the loop closing the 3'-terminal stem of the 18S rRNA, using S-adenosyl-L-methionine as a methyl donor. IEA GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity GSVIVG01027529001 15965410 15970076 GO:0006364 rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. IEA Catalysis of the dimethylation two adjacent A residues in the loop closing the 3'-terminal stem of the 18S rRNA, using S-adenosyl-L-methionine as a methyl donor. IEA GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity GSVIVG01027529001 15965410 15970076 GO:0000154 rRNA modification The covalent alteration of one or more nucleotides within an rRNA molecule to produce an rRNA molecule with a sequence that differs from that coded genetically. IEA Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule. IEA GO:0008649 rRNA methyltransferase activity GSVIVG01027529001 15965410 15970076 GO:0006364 rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. IEA Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule. IEA GO:0008649 rRNA methyltransferase activity GSVIVG01027529001 15965410 15970076 GO:0000154 rRNA modification The covalent alteration of one or more nucleotides within an rRNA molecule to produce an rRNA molecule with a sequence that differs from that coded genetically. IEA Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to an adenine residue in an rRNA molecule. IEA GO:0016433 rRNA (adenine) methyltransferase activity GSVIVG01027529001 15965410 15970076 GO:0006364 rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. IEA Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to an adenine residue in an rRNA molecule. IEA GO:0016433 rRNA (adenine) methyltransferase activity GSVIVG01020446001 19293518 19296332 GSVIVG01029976001 2551103 2589289 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0008076 voltage-gated potassium channel complex A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01029976001 2551103 2589289 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01029976001 2551103 2589289 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0008076 voltage-gated potassium channel complex A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029976001 2551103 2589289 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01003726001 7439422 7444194 GSVIVG01001963001 16323933 16326346 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the transfer of a phosphate group from one position to another within a single molecule. IEA GO:0016868 intramolecular transferase activity, phosphotransferases GSVIVG01000003001 2616036 2620460 GSVIVG01032817001 515139 523641 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01032817001 515139 523641 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01025948001 26814787 26824073 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01020198001 9185076 9187047 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01036151001 20050389 20050541 GSVIVG01014389001 3302032 3310746 GSVIVG01034190001 14541923 14548657 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005667 transcription factor complex A protein complex, distinct from RNA polymerase, that associates with DNA at promoters or at cis-acting regulatory sequences, by direct binding or by interaction with other DNA-binding polypeptides or complexes, and regulates transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01021895001 5966593 5969845 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01021895001 5966593 5969845 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021036001 14942827 14946221 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA Catalysis of the reaction: protein serine/threonine/tyrosine phosphate + H2O = protein serine/threonine/tyrosine + phosphate. IEA GO:0008138 protein tyrosine/serine/threonine phosphatase activity GSVIVG01021036001 14942827 14946221 GO:0016311 dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. IEA Catalysis of the reaction: protein serine/threonine/tyrosine phosphate + H2O = protein serine/threonine/tyrosine + phosphate. IEA GO:0008138 protein tyrosine/serine/threonine phosphatase activity GSVIVG01021036001 14942827 14946221 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. IEA GO:0016791 phosphatase activity GSVIVG01021036001 14942827 14946221 GO:0016311 dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. IEA Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. IEA GO:0016791 phosphatase activity GSVIVG01010949001 2728562 2734306 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of potassium ions (K+) from one side of a membrane to the other. IEA GO:0015079 potassium ion transmembrane transporter activity GSVIVG01015198001 1758086 1767553 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01015198001 1758086 1767553 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01015198001 1758086 1767553 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01015198001 1758086 1767553 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017324001 6723784 6725857 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01038738001 200956 208628 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of potassium ions (K+) from one side of a membrane to the other. IEA GO:0015079 potassium ion transmembrane transporter activity GSVIVG01022183001 17258807 17261225 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GSVIVG01022843001 18842700 18856106 GO:0006544 glycine metabolic process The chemical reactions and pathways involving glycine, aminoethanoic acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01022843001 18842700 18856106 GO:0006563 L-serine metabolic process The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01022843001 18842700 18856106 GO:0006544 glycine metabolic process The chemical reactions and pathways involving glycine, aminoethanoic acid. IEA Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine. IEA GO:0004372 glycine hydroxymethyltransferase activity GSVIVG01022843001 18842700 18856106 GO:0006563 L-serine metabolic process The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. IEA Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine. IEA GO:0004372 glycine hydroxymethyltransferase activity GSVIVG01022843001 18842700 18856106 GO:0006544 glycine metabolic process The chemical reactions and pathways involving glycine, aminoethanoic acid. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01022843001 18842700 18856106 GO:0006563 L-serine metabolic process The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01036069001 21077729 21109308 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01036069001 21077729 21109308 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01036069001 21077729 21109308 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01036069001 21077729 21109308 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01036069001 21077729 21109308 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01036069001 21077729 21109308 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01036069001 21077729 21109308 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01036069001 21077729 21109308 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01036069001 21077729 21109308 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01036069001 21077729 21109308 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01036069001 21077729 21109308 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01036069001 21077729 21109308 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01036069001 21077729 21109308 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01036069001 21077729 21109308 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01036069001 21077729 21109308 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01036069001 21077729 21109308 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01036069001 21077729 21109308 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01036069001 21077729 21109308 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01036069001 21077729 21109308 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01036069001 21077729 21109308 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01036069001 21077729 21109308 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01036069001 21077729 21109308 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01036069001 21077729 21109308 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01036069001 21077729 21109308 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01034031001 15713311 15714875 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025103001 4475820 4475882 GSVIVG01034142001 14861870 14862034 GSVIVG01024929001 5951143 5953064 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GSVIVG01035344001 653635 659952 GSVIVG01016899001 2383308 2386577 GSVIVG01006278001 24460771 24461672 GSVIVG01010752001 22176870 22177581 GSVIVG01025803001 11710332 11711297 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01037203001 28012083 28015625 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000222001 16228570 16231247 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01000222001 16228570 16231247 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01000222001 16228570 16231247 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01000222001 16228570 16231247 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01000222001 16228570 16231247 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01000222001 16228570 16231247 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01000222001 16228570 16231247 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000222001 16228570 16231247 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000222001 16228570 16231247 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000222001 16228570 16231247 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000222001 16228570 16231247 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01000222001 16228570 16231247 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01031549001 17260847 17261185 GSVIVG01023452001 11629989 11632712 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01034329001 18059724 18060047 GSVIVG01027169001 17287486 17290863 GSVIVG01031662001 19770329 19774873 GSVIVG01017343001 6900919 6917995 GSVIVG01027017001 18550288 18555827 GSVIVG01002330001 34130232 34130670 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004185 serine-type carboxypeptidase activity GSVIVG01037838001 7321433 7322062 GSVIVG01033268001 21988932 21989480 GSVIVG01028487001 8285635 8286528 GSVIVG01006243001 23935333 23939075 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01006243001 23935333 23939075 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01006243001 23935333 23939075 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006243001 23935333 23939075 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003347001 9232016 9237698 GSVIVG01009312001 7278385 7282582 GSVIVG01016227001 6232343 6239138 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016227001 6232343 6239138 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016227001 6232343 6239138 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016227001 6232343 6239138 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016227001 6232343 6239138 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016227001 6232343 6239138 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01016227001 6232343 6239138 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01016227001 6232343 6239138 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01016227001 6232343 6239138 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01016227001 6232343 6239138 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01016227001 6232343 6239138 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016227001 6232343 6239138 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016227001 6232343 6239138 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016227001 6232343 6239138 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016227001 6232343 6239138 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016227001 6232343 6239138 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01016227001 6232343 6239138 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01016227001 6232343 6239138 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01016227001 6232343 6239138 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01016227001 6232343 6239138 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01023290001 20052150 20062569 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity. IEA GO:0004721 phosphoprotein phosphatase activity GSVIVG01002049001 32458347 32462089 GSVIVG01012760001 23755966 23757141 GSVIVG01011064001 1873745 1879108 GSVIVG01012539001 955568 961102 The action of a molecule that contributes to the structural integrity of a cell wall. IEA GO:0005199 structural constituent of cell wall GSVIVG01008737001 1565405 1566718 GO:0006694 steroid biosynthetic process The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01008737001 1565405 1566718 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01008737001 1565405 1566718 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01008737001 1565405 1566718 GO:0006694 steroid biosynthetic process The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification. IEA Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid. IEA GO:0008825 cyclopropane-fatty-acyl-phospholipid synthase activity GSVIVG01008737001 1565405 1566718 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid. IEA GO:0008825 cyclopropane-fatty-acyl-phospholipid synthase activity GSVIVG01008737001 1565405 1566718 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid. IEA GO:0008825 cyclopropane-fatty-acyl-phospholipid synthase activity GSVIVG01004963001 17105370 17107329 GSVIVG01005194001 19029286 19030304 GSVIVG01014602001 5486471 5495533 GSVIVG01012272001 12864198 12866540 Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01012272001 12864198 12866540 Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01019453001 790197 790679 GSVIVG01009655001 10233988 10235820 GO:0006464 protein modification process The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009655001 10233988 10235820 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009655001 10233988 10235820 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009655001 10233988 10235820 GO:0006464 protein modification process The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). IEA Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. IEA GO:0016881 acid-amino acid ligase activity GSVIVG01009655001 10233988 10235820 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. IEA GO:0016881 acid-amino acid ligase activity GSVIVG01009655001 10233988 10235820 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. IEA GO:0016881 acid-amino acid ligase activity GSVIVG01009655001 10233988 10235820 GO:0006464 protein modification process The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01009655001 10233988 10235820 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01009655001 10233988 10235820 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01000643001 20331039 20334809 GSVIVG01012652001 364438 365964 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01012652001 364438 365964 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01012652001 364438 365964 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01012652001 364438 365964 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01014024001 9126428 9159944 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014024001 9126428 9159944 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014024001 9126428 9159944 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012279001 12951440 12952290 GO:0022904 respiratory electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01012279001 12951440 12952290 GO:0022904 respiratory electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01029382001 15915385 15917742 GSVIVG01015967001 16399893 16408556 GSVIVG01000205001 16097589 16100336 GSVIVG01031308001 495254 498938 GO:0009987 cellular process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. IEA GSVIVG01033513001 20117786 20130999 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01029884001 931599 932179 GSVIVG01034272001 13924117 13925698 GSVIVG01030941001 19440155 19446055 GSVIVG01023560001 9683605 9685074 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01023560001 9683605 9685074 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01023560001 9683605 9685074 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01023560001 9683605 9685074 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01038069001 17407195 17408381 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01038069001 17407195 17408381 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01038069001 17407195 17408381 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01038069001 17407195 17408381 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01014287001 2325685 2327321 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01009932001 12509086 12513293 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01009932001 12509086 12513293 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01001871001 6491783 6505242 GSVIVG01015821001 17886450 17891388 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015821001 17886450 17891388 Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. IEA GO:0008483 transaminase activity GSVIVG01015821001 17886450 17891388 Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01002093001 32802260 32815128 GSVIVG01016300001 5369865 5375890 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01016300001 5369865 5375890 GO:0019941 modification-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01016300001 5369865 5375890 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01016300001 5369865 5375890 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01016300001 5369865 5375890 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016300001 5369865 5375890 GO:0019941 modification-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016300001 5369865 5375890 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016300001 5369865 5375890 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016300001 5369865 5375890 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01016300001 5369865 5375890 GO:0019941 modification-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01016300001 5369865 5375890 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01016300001 5369865 5375890 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01016300001 5369865 5375890 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01016300001 5369865 5375890 GO:0019941 modification-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01016300001 5369865 5375890 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01016300001 5369865 5375890 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01015874001 18805391 18807920 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01015874001 18805391 18807920 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008751001 1711994 1712514 GSVIVG01005131001 18450333 18451588 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01034171001 14647463 14659445 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01024986001 5491931 5493551 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01024986001 5491931 5493551 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01024244001 157262 162152 GSVIVG01009063001 4631192 4631628 GSVIVG01033323001 21501285 21513580 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01033323001 21501285 21513580 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01033323001 21501285 21513580 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033323001 21501285 21513580 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01033323001 21501285 21513580 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01018027001 5595930 5622085 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01018027001 5595930 5622085 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01018027001 5595930 5622085 GO:0008272 sulfate transport The directed movement of sulfate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01018027001 5595930 5622085 GO:0008272 sulfate transport The directed movement of sulfate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01018027001 5595930 5622085 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01018027001 5595930 5622085 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01018027001 5595930 5622085 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01018027001 5595930 5622085 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01018027001 5595930 5622085 GO:0008272 sulfate transport The directed movement of sulfate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01018027001 5595930 5622085 GO:0008272 sulfate transport The directed movement of sulfate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01018027001 5595930 5622085 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01018027001 5595930 5622085 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01000210001 16109278 16111770 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01000210001 16109278 16111770 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01000210001 16109278 16111770 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01000210001 16109278 16111770 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01000210001 16109278 16111770 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036729001 23237784 23238509 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01036729001 23237784 23238509 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01012618001 77027 90103 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01012618001 77027 90103 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01012618001 77027 90103 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01012618001 77027 90103 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012529001 675654 679494 GSVIVG01016083001 18596480 18602131 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01018887001 18957444 18961992 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01034510001 20145938 20146577 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01014743001 9136131 9146070 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01009480001 8731499 8735504 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion. IEA GO:0004806 triglyceride lipase activity GSVIVG01015658001 15117058 15117570 GSVIVG01020314001 21494508 21498389 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020314001 21494508 21498389 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020314001 21494508 21498389 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020314001 21494508 21498389 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020314001 21494508 21498389 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01020314001 21494508 21498389 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01023830001 3151787 3152495 GSVIVG01009886001 12136487 12137121 GSVIVG01000755001 411294 412711 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01000755001 411294 412711 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01030116001 9995859 10000278 GO:0006568 tryptophan metabolic process The chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030116001 9995859 10000278 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030116001 9995859 10000278 GO:0006568 tryptophan metabolic process The chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid. IEA Catalysis of the reaction: 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O. IEA GO:0004425 indole-3-glycerol-phosphate synthase activity GSVIVG01030116001 9995859 10000278 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O. IEA GO:0004425 indole-3-glycerol-phosphate synthase activity GSVIVG01021420001 5163352 5167643 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01021420001 5163352 5167643 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030077 plasma membrane light-harvesting complex A plasma membrane protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center. Examples of this complex are found in bacterial species. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01021420001 5163352 5167643 GO:0009772 photosynthetic electron transport in photosystem II Electrons move from the primary electron acceptor (Quinone, Q) through a chain of electron transport molecules in the thylakoid membrane until they reach the ultimate electron acceptor of Photosystem II, which is plastocyanin (PC). The electron is then passed to the P700 chlorophyll a molecules of the reaction centre of photosystem I. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01021420001 5163352 5167643 GO:0009772 photosynthetic electron transport in photosystem II Electrons move from the primary electron acceptor (Quinone, Q) through a chain of electron transport molecules in the thylakoid membrane until they reach the ultimate electron acceptor of Photosystem II, which is plastocyanin (PC). The electron is then passed to the P700 chlorophyll a molecules of the reaction centre of photosystem I. IEA GO:0030077 plasma membrane light-harvesting complex A plasma membrane protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center. Examples of this complex are found in bacterial species. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01021420001 5163352 5167643 GO:0019684 photosynthesis, light reaction The light reactions of photosynthesis, which take place in photosystems II and I. Light energy is harvested and used to power the transfer of electrons among a series of electron donors and acceptors. The final electron acceptor is NADP+, which is reduced to NADPH. NADPH generated from light reactions is used in sugar synthesis in dark reactions. Light reactions also generate a proton motive force across the thylakoid membrane, and the proton gradient is used to synthesize ATP. There are two chemical reactions involved in the light reactions: water oxidation in photosystem II, and NADP reduction in photosystem I. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01021420001 5163352 5167643 GO:0019684 photosynthesis, light reaction The light reactions of photosynthesis, which take place in photosystems II and I. Light energy is harvested and used to power the transfer of electrons among a series of electron donors and acceptors. The final electron acceptor is NADP+, which is reduced to NADPH. NADPH generated from light reactions is used in sugar synthesis in dark reactions. Light reactions also generate a proton motive force across the thylakoid membrane, and the proton gradient is used to synthesize ATP. There are two chemical reactions involved in the light reactions: water oxidation in photosystem II, and NADP reduction in photosystem I. IEA GO:0030077 plasma membrane light-harvesting complex A plasma membrane protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center. Examples of this complex are found in bacterial species. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01021420001 5163352 5167643 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01021420001 5163352 5167643 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0030077 plasma membrane light-harvesting complex A plasma membrane protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center. Examples of this complex are found in bacterial species. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01021420001 5163352 5167643 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01021420001 5163352 5167643 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030077 plasma membrane light-harvesting complex A plasma membrane protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center. Examples of this complex are found in bacterial species. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01021420001 5163352 5167643 GO:0009772 photosynthetic electron transport in photosystem II Electrons move from the primary electron acceptor (Quinone, Q) through a chain of electron transport molecules in the thylakoid membrane until they reach the ultimate electron acceptor of Photosystem II, which is plastocyanin (PC). The electron is then passed to the P700 chlorophyll a molecules of the reaction centre of photosystem I. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01021420001 5163352 5167643 GO:0009772 photosynthetic electron transport in photosystem II Electrons move from the primary electron acceptor (Quinone, Q) through a chain of electron transport molecules in the thylakoid membrane until they reach the ultimate electron acceptor of Photosystem II, which is plastocyanin (PC). The electron is then passed to the P700 chlorophyll a molecules of the reaction centre of photosystem I. IEA GO:0030077 plasma membrane light-harvesting complex A plasma membrane protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center. Examples of this complex are found in bacterial species. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01021420001 5163352 5167643 GO:0019684 photosynthesis, light reaction The light reactions of photosynthesis, which take place in photosystems II and I. Light energy is harvested and used to power the transfer of electrons among a series of electron donors and acceptors. The final electron acceptor is NADP+, which is reduced to NADPH. NADPH generated from light reactions is used in sugar synthesis in dark reactions. Light reactions also generate a proton motive force across the thylakoid membrane, and the proton gradient is used to synthesize ATP. There are two chemical reactions involved in the light reactions: water oxidation in photosystem II, and NADP reduction in photosystem I. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01021420001 5163352 5167643 GO:0019684 photosynthesis, light reaction The light reactions of photosynthesis, which take place in photosystems II and I. Light energy is harvested and used to power the transfer of electrons among a series of electron donors and acceptors. The final electron acceptor is NADP+, which is reduced to NADPH. NADPH generated from light reactions is used in sugar synthesis in dark reactions. Light reactions also generate a proton motive force across the thylakoid membrane, and the proton gradient is used to synthesize ATP. There are two chemical reactions involved in the light reactions: water oxidation in photosystem II, and NADP reduction in photosystem I. IEA GO:0030077 plasma membrane light-harvesting complex A plasma membrane protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center. Examples of this complex are found in bacterial species. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01021420001 5163352 5167643 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01021420001 5163352 5167643 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0030077 plasma membrane light-harvesting complex A plasma membrane protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center. Examples of this complex are found in bacterial species. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01018753001 20178885 20189283 GSVIVG01009758001 11025678 11029475 GO:0006231 dTMP biosynthetic process The chemical reactions and pathways resulting in the formation of dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate). IEA Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+. IEA GO:0004146 dihydrofolate reductase activity GSVIVG01009758001 11025678 11029475 GO:0006545 glycine biosynthetic process The chemical reactions and pathways resulting in the formation of glycine, aminoethanoic acid. IEA Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+. IEA GO:0004146 dihydrofolate reductase activity GSVIVG01009758001 11025678 11029475 GO:0006730 one-carbon metabolic process The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. IEA Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+. IEA GO:0004146 dihydrofolate reductase activity GSVIVG01009758001 11025678 11029475 GO:0009165 nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates). IEA Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+. IEA GO:0004146 dihydrofolate reductase activity GSVIVG01009758001 11025678 11029475 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+. IEA GO:0004146 dihydrofolate reductase activity GSVIVG01009758001 11025678 11029475 GO:0006231 dTMP biosynthetic process The chemical reactions and pathways resulting in the formation of dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate). IEA Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP. IEA GO:0004799 thymidylate synthase activity GSVIVG01009758001 11025678 11029475 GO:0006545 glycine biosynthetic process The chemical reactions and pathways resulting in the formation of glycine, aminoethanoic acid. IEA Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP. IEA GO:0004799 thymidylate synthase activity GSVIVG01009758001 11025678 11029475 GO:0006730 one-carbon metabolic process The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. IEA Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP. IEA GO:0004799 thymidylate synthase activity GSVIVG01009758001 11025678 11029475 GO:0009165 nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates). IEA Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP. IEA GO:0004799 thymidylate synthase activity GSVIVG01009758001 11025678 11029475 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP. IEA GO:0004799 thymidylate synthase activity GSVIVG01009758001 11025678 11029475 GO:0006231 dTMP biosynthetic process The chemical reactions and pathways resulting in the formation of dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate). IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01009758001 11025678 11029475 GO:0006545 glycine biosynthetic process The chemical reactions and pathways resulting in the formation of glycine, aminoethanoic acid. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01009758001 11025678 11029475 GO:0006730 one-carbon metabolic process The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01009758001 11025678 11029475 GO:0009165 nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates). IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01009758001 11025678 11029475 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01029947001 1993964 1994625 GSVIVG01025809001 11628640 11632801 GSVIVG01013631001 1949856 1952420 GSVIVG01003343001 9191203 9194236 GO:0015991 ATP hydrolysis coupled proton transport The transport of protons against an electrochemical gradient, using energy from ATP hydrolysis. IEA GO:0033179 proton-transporting V-type ATPase, V0 domain A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01033118001 25883409 25885120 GSVIVG01033628001 19122483 19124117 GSVIVG01032399001 26961570 26966511 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01032399001 26961570 26966511 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01032399001 26961570 26966511 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01032399001 26961570 26966511 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037289001 16409042 16413561 GSVIVG01027493001 16221913 16224544 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01036084001 20868559 20879661 GSVIVG01031248001 835998 839975 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031248001 835998 839975 GO:0007596 blood coagulation The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031248001 835998 839975 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with thrombin to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state. IEA GO:0015057 thrombin receptor activity GSVIVG01031248001 835998 839975 GO:0007596 blood coagulation The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with thrombin to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state. IEA GO:0015057 thrombin receptor activity GSVIVG01021519001 6483414 6522203 GSVIVG01010804001 22803233 22809231 GSVIVG01027420001 16892319 16893060 GSVIVG01013251001 6211851 6213577 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01013251001 6211851 6213577 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008318001 3301318 3304411 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008318001 3301318 3304411 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008318001 3301318 3304411 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008318001 3301318 3304411 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008318001 3301318 3304411 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008318001 3301318 3304411 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008318001 3301318 3304411 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01008318001 3301318 3304411 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01008318001 3301318 3304411 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01008318001 3301318 3304411 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01008318001 3301318 3304411 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01008318001 3301318 3304411 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01008318001 3301318 3304411 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01008318001 3301318 3304411 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01008318001 3301318 3304411 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01008318001 3301318 3304411 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01008318001 3301318 3304411 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01008318001 3301318 3304411 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01033278001 21929973 21934990 GSVIVG01038685001 21017273 21022887 GSVIVG01028159001 4301428 4303090 GSVIVG01007216001 30924809 30928166 GSVIVG01033691001 18623547 18625680 GO:0009664 plant-type cell wall organization A process that results in the assembly and arrangement of constituent parts of the cellulose and pectin-containing cell wall, or in the disassembly of the cellulose and pectin-containing cell wall. This process is carried out at the cellular level. An example of this process is found in Arabidopsis thaliana. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA GSVIVG01033691001 18623547 18625680 GO:0009664 plant-type cell wall organization A process that results in the assembly and arrangement of constituent parts of the cellulose and pectin-containing cell wall, or in the disassembly of the cellulose and pectin-containing cell wall. This process is carried out at the cellular level. An example of this process is found in Arabidopsis thaliana. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01009989001 13176556 13178357 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01009989001 13176556 13178357 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01009989001 13176556 13178357 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01009989001 13176556 13178357 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01033129001 8105892 8110129 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01033129001 8105892 8110129 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01033129001 8105892 8110129 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01033129001 8105892 8110129 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01033129001 8105892 8110129 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01033129001 8105892 8110129 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01033129001 8105892 8110129 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033129001 8105892 8110129 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033129001 8105892 8110129 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033129001 8105892 8110129 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033129001 8105892 8110129 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033129001 8105892 8110129 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033129001 8105892 8110129 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033129001 8105892 8110129 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033129001 8105892 8110129 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033129001 8105892 8110129 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033129001 8105892 8110129 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033129001 8105892 8110129 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033129001 8105892 8110129 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01033129001 8105892 8110129 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01033129001 8105892 8110129 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01033129001 8105892 8110129 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01033129001 8105892 8110129 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01033129001 8105892 8110129 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01035471001 1529078 1552457 GSVIVG01028427001 7439192 7445615 GSVIVG01002369001 34431115 34437835 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01024025001 1674326 1677060 GSVIVG01023355001 19393434 19401940 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01022169001 17201678 17202441 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01022169001 17201678 17202441 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01013258001 6161355 6173803 GSVIVG01011034001 2082807 2083625 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01011034001 2082807 2083625 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01011034001 2082807 2083625 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01009894001 12200592 12208186 GSVIVG01036110001 20570749 20572268 GSVIVG01022814001 16903940 16905266 GO:0007585 respiratory gaseous exchange The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. IEA GO:0005740 mitochondrial envelope The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01022814001 16903940 16905266 GO:0007585 respiratory gaseous exchange The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01022814001 16903940 16905266 GO:0007585 respiratory gaseous exchange The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01022814001 16903940 16905266 GO:0007585 respiratory gaseous exchange The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. IEA GO:0070469 respiratory chain The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01022814001 16903940 16905266 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0005740 mitochondrial envelope The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01022814001 16903940 16905266 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01022814001 16903940 16905266 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01022814001 16903940 16905266 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0070469 respiratory chain The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01022814001 16903940 16905266 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005740 mitochondrial envelope The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01022814001 16903940 16905266 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01022814001 16903940 16905266 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01022814001 16903940 16905266 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0070469 respiratory chain The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01022814001 16903940 16905266 GO:0007585 respiratory gaseous exchange The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. IEA GO:0005740 mitochondrial envelope The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022814001 16903940 16905266 GO:0007585 respiratory gaseous exchange The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022814001 16903940 16905266 GO:0007585 respiratory gaseous exchange The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022814001 16903940 16905266 GO:0007585 respiratory gaseous exchange The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. IEA GO:0070469 respiratory chain The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022814001 16903940 16905266 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0005740 mitochondrial envelope The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022814001 16903940 16905266 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022814001 16903940 16905266 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022814001 16903940 16905266 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0070469 respiratory chain The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022814001 16903940 16905266 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005740 mitochondrial envelope The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022814001 16903940 16905266 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022814001 16903940 16905266 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022814001 16903940 16905266 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0070469 respiratory chain The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022814001 16903940 16905266 GO:0007585 respiratory gaseous exchange The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. IEA GO:0005740 mitochondrial envelope The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01022814001 16903940 16905266 GO:0007585 respiratory gaseous exchange The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01022814001 16903940 16905266 GO:0007585 respiratory gaseous exchange The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01022814001 16903940 16905266 GO:0007585 respiratory gaseous exchange The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. IEA GO:0070469 respiratory chain The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01022814001 16903940 16905266 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0005740 mitochondrial envelope The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01022814001 16903940 16905266 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01022814001 16903940 16905266 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01022814001 16903940 16905266 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0070469 respiratory chain The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01022814001 16903940 16905266 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005740 mitochondrial envelope The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01022814001 16903940 16905266 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01022814001 16903940 16905266 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01022814001 16903940 16905266 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0070469 respiratory chain The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01022814001 16903940 16905266 GO:0007585 respiratory gaseous exchange The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. IEA GO:0005740 mitochondrial envelope The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01022814001 16903940 16905266 GO:0007585 respiratory gaseous exchange The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01022814001 16903940 16905266 GO:0007585 respiratory gaseous exchange The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01022814001 16903940 16905266 GO:0007585 respiratory gaseous exchange The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. IEA GO:0070469 respiratory chain The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01022814001 16903940 16905266 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0005740 mitochondrial envelope The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01022814001 16903940 16905266 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01022814001 16903940 16905266 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01022814001 16903940 16905266 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0070469 respiratory chain The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01022814001 16903940 16905266 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005740 mitochondrial envelope The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01022814001 16903940 16905266 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01022814001 16903940 16905266 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01022814001 16903940 16905266 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0070469 respiratory chain The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01030502001 6254942 6262636 GSVIVG01027862001 8742110 8744123 GSVIVG01034538001 19691814 19692987 GSVIVG01024701001 7625670 7628115 GSVIVG01021237001 2861874 2866847 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01021237001 2861874 2866847 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01014935001 12274776 12280143 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01014935001 12274776 12280143 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01014935001 12274776 12280143 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01014935001 12274776 12280143 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01034152001 14801716 14806480 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01034152001 14801716 14806480 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01034152001 14801716 14806480 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01034152001 14801716 14806480 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01034152001 14801716 14806480 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01034152001 14801716 14806480 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01037354001 15277852 15282116 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008778001 1897286 1948700 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01008778001 1897286 1948700 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01008778001 1897286 1948700 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA helix. IEA GO:0003678 DNA helicase activity GSVIVG01008778001 1897286 1948700 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA helix. IEA GO:0003678 DNA helicase activity GSVIVG01008778001 1897286 1948700 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008778001 1897286 1948700 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032832001 387588 397585 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01032832001 387588 397585 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031552001 17232675 17239493 GSVIVG01027683001 14343591 14350488 The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01024256001 270916 272612 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0005886 plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01024256001 270916 272612 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01031240001 941773 955196 GO:0030418 nicotianamine biosynthetic process The chemical reactions and pathways resulting in the formation of nicotianamine, 2(S),3'2(S),3''(S)-N-(N-(3-amino-3-carboxypropyl)-3-amino-3-carboxypropyl)-azetidine-2-carboxylic acid. IEA Catalysis of the reaction: 3 S-adenosyl-L-methionine = 3 5'-S-methyl-5'-thioadenosine + nicotianamine. IEA GO:0030410 nicotianamine synthase activity GSVIVG01017045001 3744451 3748619 GSVIVG01001627001 21500110 21501071 GSVIVG01001896001 6899438 6908810 GSVIVG01011075001 1791162 1794730 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01005206001 19190912 19196143 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01005206001 19190912 19196143 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01023966001 2084983 2086497 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024921001 6014664 6018771 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01024921001 6014664 6018771 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01015373001 3088785 3105908 GSVIVG01034651001 13277703 13347678 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01034651001 13277703 13347678 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01021401001 4934999 4936787 GSVIVG01018127001 6784989 6797069 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018127001 6784989 6797069 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018127001 6784989 6797069 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018127001 6784989 6797069 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028099001 3788865 3792519 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion. IEA GO:0004806 triglyceride lipase activity GSVIVG01015218001 1896779 1898922 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01006145001 42128015 42128509 GSVIVG01007176001 30638839 30663034 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GSVIVG01035879001 5201795 5204455 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. IEA GO:0016597 amino acid binding GSVIVG01023765001 10783401 10783538 GSVIVG01032739001 1152601 1154833 GSVIVG01011979001 2445362 2456449 GO:0006099 tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01011979001 2445362 2456449 GO:0006099 tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. IEA Catalysis of the reaction: phosphate + oxaloacetate = H2O + phosphoenolpyruvate + CO2. IEA GO:0008964 phosphoenolpyruvate carboxylase activity GSVIVG01010538001 16825488 16834648 GO:0006298 mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010538001 16825488 16834648 GO:0006298 mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. IEA Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches. IEA GO:0030983 mismatched DNA binding GSVIVG01028403001 7210986 7220524 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019673001 2368434 2370940 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019673001 2368434 2370940 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019673001 2368434 2370940 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019673001 2368434 2370940 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019673001 2368434 2370940 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01019673001 2368434 2370940 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01019673001 2368434 2370940 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01019673001 2368434 2370940 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01028689001 12160515 12170599 GSVIVG01031694001 20269993 20270547 GSVIVG01038562001 21822211 21823097 GSVIVG01032756001 997651 1002507 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01032756001 997651 1002507 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01032756001 997651 1002507 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01032756001 997651 1002507 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01029558001 21572109 21572642 GSVIVG01016953001 2920372 2934725 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016953001 2920372 2934725 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016953001 2920372 2934725 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016953001 2920372 2934725 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Interacting selectively and non-covalently with damaged DNA. IEA GO:0003684 damaged DNA binding GSVIVG01016953001 2920372 2934725 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with damaged DNA. IEA GO:0003684 damaged DNA binding GSVIVG01016953001 2920372 2934725 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA Interacting selectively and non-covalently with damaged DNA. IEA GO:0003684 damaged DNA binding GSVIVG01016953001 2920372 2934725 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01016953001 2920372 2934725 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01016953001 2920372 2934725 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01016953001 2920372 2934725 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01016953001 2920372 2934725 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01016953001 2920372 2934725 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01016953001 2920372 2934725 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016953001 2920372 2934725 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016953001 2920372 2934725 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016953001 2920372 2934725 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01016953001 2920372 2934725 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01016953001 2920372 2934725 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01016953001 2920372 2934725 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01016953001 2920372 2934725 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01016953001 2920372 2934725 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01006150001 42172806 42174948 GO:0009690 cytokinin metabolic process The chemical reactions and pathways involving cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01006150001 42172806 42174948 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01006150001 42172806 42174948 GO:0009690 cytokinin metabolic process The chemical reactions and pathways involving cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01006150001 42172806 42174948 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01006150001 42172806 42174948 GO:0009690 cytokinin metabolic process The chemical reactions and pathways involving cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators. IEA Catalysis of the reaction: N6-dimethylallyladenine + acceptor + H2O = adenine + 3-methylbut-2-enal + reduced electron acceptor. IEA GO:0019139 cytokinin dehydrogenase activity GSVIVG01006150001 42172806 42174948 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: N6-dimethylallyladenine + acceptor + H2O = adenine + 3-methylbut-2-enal + reduced electron acceptor. IEA GO:0019139 cytokinin dehydrogenase activity GSVIVG01006150001 42172806 42174948 GO:0009690 cytokinin metabolic process The chemical reactions and pathways involving cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01006150001 42172806 42174948 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01031219001 1088665 1101637 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. IEA GO:0016853 isomerase activity GSVIVG01009379001 7890140 7891713 GSVIVG01023022001 16777315 16778939 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01015021001 516935 517620 GSVIVG01011622001 5829740 5832049 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01037200001 28030022 28034687 GSVIVG01018133001 6896712 6914835 GSVIVG01000732001 282368 284868 GSVIVG01000789001 176579 178617 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01000789001 176579 178617 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01000789001 176579 178617 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01000789001 176579 178617 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01000789001 176579 178617 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01000789001 176579 178617 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01000789001 176579 178617 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01000789001 176579 178617 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01033257001 22132237 22133757 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01033257001 22132237 22133757 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01003684001 12098218 12101113 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with a mating-type factor pheromone to initiate a change in cell activity. IEA GO:0004932 mating-type factor pheromone receptor activity GSVIVG01003684001 12098218 12101113 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with a mating-type factor pheromone to initiate a change in cell activity. IEA GO:0004932 mating-type factor pheromone receptor activity GSVIVG01003684001 12098218 12101113 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with a mating-type factor pheromone to initiate a change in cell activity. IEA GO:0004932 mating-type factor pheromone receptor activity GSVIVG01003684001 12098218 12101113 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with a mating-type factor pheromone to initiate a change in cell activity. IEA GO:0004932 mating-type factor pheromone receptor activity GSVIVG01003684001 12098218 12101113 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with a mating-type factor pheromone to initiate a change in cell activity. IEA GO:0004932 mating-type factor pheromone receptor activity GSVIVG01003684001 12098218 12101113 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with a mating-type factor pheromone to initiate a change in cell activity. IEA GO:0004932 mating-type factor pheromone receptor activity GSVIVG01003684001 12098218 12101113 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01003684001 12098218 12101113 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01003684001 12098218 12101113 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01003684001 12098218 12101113 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01003684001 12098218 12101113 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01003684001 12098218 12101113 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01018258001 12350318 12363285 GSVIVG01008060001 6161761 6166581 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01034296001 14317113 14317987 GSVIVG01036787001 22546264 22547496 GSVIVG01033097001 25686541 25691433 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01001279001 4948964 4950534 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01021527001 6650569 6650700 GSVIVG01015177001 1593487 1593853 GSVIVG01022098001 16573422 16578723 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate. IEA GO:0004629 phospholipase C activity GSVIVG01022098001 16573422 16578723 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. IEA GO:0008081 phosphoric diester hydrolase activity GSVIVG01014704001 8791187 8805475 GSVIVG01025678001 13002743 13004984 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016471 vacuolar proton-transporting V-type ATPase complex A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01001126001 22842549 22844572 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01001126001 22842549 22844572 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01007201001 30747467 30753512 GSVIVG01034732001 8571291 8574916 GSVIVG01012877001 6454578 6464691 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01012877001 6454578 6464691 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01010204001 17305088 17308607 GSVIVG01024108001 1004686 1005093 GSVIVG01002470001 34928637 34933442 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01002470001 34928637 34933442 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01002470001 34928637 34933442 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036620001 19294756 19295735 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01035803001 4513024 4516324 GSVIVG01015534001 4628056 4629002 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01015534001 4628056 4629002 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01010335001 19577702 19585175 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01023124001 22321793 22322668 GSVIVG01028854001 18058680 18062107 GSVIVG01023871001 2857244 2858851 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01023871001 2857244 2858851 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01023871001 2857244 2858851 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01023871001 2857244 2858851 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01010876001 16540456 16541682 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01028065001 3566084 3570106 GSVIVG01007075001 30064850 30072419 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007075001 30064850 30072419 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007075001 30064850 30072419 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007075001 30064850 30072419 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007075001 30064850 30072419 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007075001 30064850 30072419 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007075001 30064850 30072419 GO:0015693 magnesium ion transport The directed movement of magnesium (Mg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007075001 30064850 30072419 GO:0015693 magnesium ion transport The directed movement of magnesium (Mg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007075001 30064850 30072419 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007075001 30064850 30072419 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007075001 30064850 30072419 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007075001 30064850 30072419 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007075001 30064850 30072419 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007075001 30064850 30072419 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007075001 30064850 30072419 GO:0015693 magnesium ion transport The directed movement of magnesium (Mg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007075001 30064850 30072419 GO:0015693 magnesium ion transport The directed movement of magnesium (Mg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007075001 30064850 30072419 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mg2+(out) = ADP + phosphate + Mg2+(in). IEA GO:0015444 magnesium-importing ATPase activity GSVIVG01007075001 30064850 30072419 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mg2+(out) = ADP + phosphate + Mg2+(in). IEA GO:0015444 magnesium-importing ATPase activity GSVIVG01007075001 30064850 30072419 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mg2+(out) = ADP + phosphate + Mg2+(in). IEA GO:0015444 magnesium-importing ATPase activity GSVIVG01007075001 30064850 30072419 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mg2+(out) = ADP + phosphate + Mg2+(in). IEA GO:0015444 magnesium-importing ATPase activity GSVIVG01007075001 30064850 30072419 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mg2+(out) = ADP + phosphate + Mg2+(in). IEA GO:0015444 magnesium-importing ATPase activity GSVIVG01007075001 30064850 30072419 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mg2+(out) = ADP + phosphate + Mg2+(in). IEA GO:0015444 magnesium-importing ATPase activity GSVIVG01007075001 30064850 30072419 GO:0015693 magnesium ion transport The directed movement of magnesium (Mg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mg2+(out) = ADP + phosphate + Mg2+(in). IEA GO:0015444 magnesium-importing ATPase activity GSVIVG01007075001 30064850 30072419 GO:0015693 magnesium ion transport The directed movement of magnesium (Mg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mg2+(out) = ADP + phosphate + Mg2+(in). IEA GO:0015444 magnesium-importing ATPase activity GSVIVG01007075001 30064850 30072419 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01007075001 30064850 30072419 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01007075001 30064850 30072419 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01007075001 30064850 30072419 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01007075001 30064850 30072419 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01007075001 30064850 30072419 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01007075001 30064850 30072419 GO:0015693 magnesium ion transport The directed movement of magnesium (Mg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01007075001 30064850 30072419 GO:0015693 magnesium ion transport The directed movement of magnesium (Mg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01007075001 30064850 30072419 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01007075001 30064850 30072419 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01007075001 30064850 30072419 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01007075001 30064850 30072419 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01007075001 30064850 30072419 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01007075001 30064850 30072419 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01007075001 30064850 30072419 GO:0015693 magnesium ion transport The directed movement of magnesium (Mg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01007075001 30064850 30072419 GO:0015693 magnesium ion transport The directed movement of magnesium (Mg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01003907001 13420850 13424904 GSVIVG01033284001 21832206 21876909 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033284001 21832206 21876909 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01033284001 21832206 21876909 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01033284001 21832206 21876909 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01033402001 20945010 20949952 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033402001 20945010 20949952 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033402001 20945010 20949952 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033402001 20945010 20949952 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the reaction: L-glutamate + H2O + NAD+ = 2-oxoglutarate + NH3 + NADH + H+. IEA GO:0004352 glutamate dehydrogenase activity GSVIVG01033402001 20945010 20949952 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: L-glutamate + H2O + NAD+ = 2-oxoglutarate + NH3 + NADH + H+. IEA GO:0004352 glutamate dehydrogenase activity GSVIVG01033402001 20945010 20949952 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: L-glutamate + H2O + NAD+ = 2-oxoglutarate + NH3 + NADH + H+. IEA GO:0004352 glutamate dehydrogenase activity GSVIVG01033402001 20945010 20949952 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033402001 20945010 20949952 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033402001 20945010 20949952 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033402001 20945010 20949952 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033402001 20945010 20949952 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033402001 20945010 20949952 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033402001 20945010 20949952 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor GSVIVG01033402001 20945010 20949952 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor GSVIVG01033402001 20945010 20949952 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor GSVIVG01007909001 7668205 7676883 GO:0007205 activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway The initiation of the activity of the inactive enzyme protein kinase C as the result of a series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol 3-phosphate. IEA GO:0004143 diacylglycerol kinase activity GSVIVG01019255001 2480145 2481694 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01013365001 937802 944696 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035040001 1088147 1099307 GSVIVG01022257001 17932419 17940351 GSVIVG01008997001 4143560 4147853 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008997001 4143560 4147853 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008997001 4143560 4147853 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the transfer of a phosphate group from one position to another within a single molecule. IEA GO:0016868 intramolecular transferase activity, phosphotransferases GSVIVG01008997001 4143560 4147853 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a phosphate group from one position to another within a single molecule. IEA GO:0016868 intramolecular transferase activity, phosphotransferases GSVIVG01036189001 9305084 9305669 GSVIVG01038095001 23463411 23471324 GO:0032313 regulation of Rab GTPase activity Any process that modulates the activity of a GTPase of the Rab family. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Increases the rate of GTP hydrolysis by a GTPase of the Rab family. IEA GO:0005097 Rab GTPase activator activity GSVIVG01027494001 16217574 16220644 GSVIVG01017733001 3001169 3003605 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01029435001 22940972 22945580 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01029435001 22940972 22945580 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01029435001 22940972 22945580 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01029435001 22940972 22945580 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01029435001 22940972 22945580 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01029435001 22940972 22945580 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01029435001 22940972 22945580 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01029435001 22940972 22945580 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01029435001 22940972 22945580 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01028644001 11488121 11496236 GSVIVG01016948001 2883492 2893404 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01016948001 2883492 2893404 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01016948001 2883492 2893404 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01016948001 2883492 2893404 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016948001 2883492 2893404 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011476001 29934781 29936781 Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01011476001 29934781 29936781 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01013278001 5715973 5719517 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01013278001 5715973 5719517 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01014168001 1034870 1045969 GSVIVG01006464001 26185375 26189425 Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01006464001 26185375 26189425 Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01005165001 18887231 18888593 GSVIVG01018206001 13234927 13235988 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005578 proteinaceous extracellular matrix A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01018206001 13234927 13235988 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0031012 extracellular matrix A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as in plants). IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01018206001 13234927 13235988 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005578 proteinaceous extracellular matrix A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01018206001 13234927 13235988 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0031012 extracellular matrix A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as in plants). IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01018206001 13234927 13235988 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005578 proteinaceous extracellular matrix A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01018206001 13234927 13235988 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0031012 extracellular matrix A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as in plants). IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01018206001 13234927 13235988 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005578 proteinaceous extracellular matrix A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01018206001 13234927 13235988 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0031012 extracellular matrix A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as in plants). IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01018206001 13234927 13235988 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005578 proteinaceous extracellular matrix A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008237 metallopeptidase activity GSVIVG01018206001 13234927 13235988 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0031012 extracellular matrix A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as in plants). IEA Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008237 metallopeptidase activity GSVIVG01018206001 13234927 13235988 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005578 proteinaceous extracellular matrix A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008237 metallopeptidase activity GSVIVG01018206001 13234927 13235988 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0031012 extracellular matrix A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as in plants). IEA Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008237 metallopeptidase activity GSVIVG01018206001 13234927 13235988 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005578 proteinaceous extracellular matrix A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01018206001 13234927 13235988 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0031012 extracellular matrix A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as in plants). IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01018206001 13234927 13235988 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005578 proteinaceous extracellular matrix A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01018206001 13234927 13235988 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0031012 extracellular matrix A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as in plants). IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01018206001 13234927 13235988 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005578 proteinaceous extracellular matrix A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01018206001 13234927 13235988 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0031012 extracellular matrix A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as in plants). IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01018206001 13234927 13235988 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005578 proteinaceous extracellular matrix A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01018206001 13234927 13235988 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0031012 extracellular matrix A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as in plants). IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01018206001 13234927 13235988 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005578 proteinaceous extracellular matrix A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01018206001 13234927 13235988 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0031012 extracellular matrix A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as in plants). IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01018206001 13234927 13235988 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005578 proteinaceous extracellular matrix A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01018206001 13234927 13235988 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0031012 extracellular matrix A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as in plants). IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01016380001 4350297 4356550 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01000756001 422306 437312 GSVIVG01034427001 16417754 16444387 GO:0016459 myosin complex A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01034427001 16417754 16444387 GO:0016459 myosin complex A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. IEA Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate. IEA GO:0003774 motor activity GSVIVG01034427001 16417754 16444387 GO:0016459 myosin complex A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034427001 16417754 16444387 GO:0016459 myosin complex A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01001278001 4923752 4935337 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001278001 4923752 4935337 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001278001 4923752 4935337 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001278001 4923752 4935337 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Catalysis of the reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]. IEA GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity GSVIVG01001278001 4923752 4935337 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]. IEA GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity GSVIVG01001278001 4923752 4935337 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]. IEA GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity GSVIVG01001278001 4923752 4935337 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01001278001 4923752 4935337 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01001278001 4923752 4935337 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01023516001 10549103 10549471 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01023516001 10549103 10549471 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01026584001 21388376 21395590 GO:0006541 glutamine metabolic process The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026584001 21388376 21395590 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026584001 21388376 21395590 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026584001 21388376 21395590 GO:0006541 glutamine metabolic process The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid. IEA Catalysis of a reaction that results in the formation of carbamoyl phosphate. IEA GO:0004086 carbamoyl-phosphate synthase activity GSVIVG01026584001 21388376 21395590 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA Catalysis of a reaction that results in the formation of carbamoyl phosphate. IEA GO:0004086 carbamoyl-phosphate synthase activity GSVIVG01026584001 21388376 21395590 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a reaction that results in the formation of carbamoyl phosphate. IEA GO:0004086 carbamoyl-phosphate synthase activity GSVIVG01032919001 24127143 24129065 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01023065001 15967871 15968140 GSVIVG01017042001 3713110 3714187 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01007563001 11993839 12000969 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01007563001 11993839 12000969 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01025328001 1988366 1989826 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01025328001 1988366 1989826 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: linoleate + O2 = (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate. IEA GO:0016165 lipoxygenase activity GSVIVG01025328001 1988366 1989826 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor. IEA GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen GSVIVG01025328001 1988366 1989826 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01019859001 3898374 3904052 GSVIVG01014505001 4596864 4600127 GSVIVG01036432001 5072803 5079670 GSVIVG01012746001 24120937 24121952 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01012746001 24120937 24121952 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025724001 12639897 12641957 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01020822001 1521116 1546616 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020822001 1521116 1546616 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01020822001 1521116 1546616 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01020822001 1521116 1546616 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020822001 1521116 1546616 Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01020822001 1521116 1546616 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01000637001 20283956 20284063 GSVIVG01008043001 6368468 6379348 GSVIVG01001953001 16043352 16044854 GSVIVG01013601001 1135274 1137500 GSVIVG01013122001 8014613 8020562 GO:0005992 trehalose biosynthetic process The chemical reactions and pathways resulting in the formation of trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007860001 8239660 8241675 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion. IEA GO:0004806 triglyceride lipase activity GSVIVG01034997001 783315 788171 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028811001 18501787 18503389 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01004070001 744509 762129 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01004070001 744509 762129 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01035769001 4157702 4159725 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035769001 4157702 4159725 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035769001 4157702 4159725 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035769001 4157702 4159725 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01035769001 4157702 4159725 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01035769001 4157702 4159725 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01035769001 4157702 4159725 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01035769001 4157702 4159725 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01035769001 4157702 4159725 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01033563001 19734994 19736181 GSVIVG01018824001 19579519 19585872 GSVIVG01003426001 14890681 14891466 GSVIVG01036033001 7599228 7641472 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01036033001 7599228 7641472 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017867001 4133108 4134158 GSVIVG01006795001 253665 253802 GSVIVG01011629001 5758853 5764898 GSVIVG01009245001 6636211 6638672 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: UDP-glucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein = UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein. IEA GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity GSVIVG01025953001 26733761 26735477 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01025953001 26733761 26735477 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01025953001 26733761 26735477 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01025953001 26733761 26735477 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01031785001 4346115 4351793 Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. IEA GO:0004519 endonuclease activity GSVIVG01025082001 4659515 4675186 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01025082001 4659515 4675186 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01025082001 4659515 4675186 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01025082001 4659515 4675186 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01025082001 4659515 4675186 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01025082001 4659515 4675186 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01025082001 4659515 4675186 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01025082001 4659515 4675186 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01025082001 4659515 4675186 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01025082001 4659515 4675186 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01025082001 4659515 4675186 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01025082001 4659515 4675186 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01025082001 4659515 4675186 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01025082001 4659515 4675186 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01025082001 4659515 4675186 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01025082001 4659515 4675186 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01025082001 4659515 4675186 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01025082001 4659515 4675186 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01025082001 4659515 4675186 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01025082001 4659515 4675186 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01025082001 4659515 4675186 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025082001 4659515 4675186 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025082001 4659515 4675186 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025082001 4659515 4675186 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019948001 12552047 12562188 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0031461 cullin-RING ubiquitin ligase complex Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity. IEA Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins. IEA GO:0031625 ubiquitin protein ligase binding GSVIVG01018592001 12647727 12649157 GSVIVG01029489001 22307438 22338999 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029489001 22307438 22338999 Catalysis of the transfer of a functional group from one position to another within a single molecule. IEA GO:0016866 intramolecular transferase activity GSVIVG01026482001 22902952 22906517 GSVIVG01013254001 6196286 6199394 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01013254001 6196286 6199394 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01013254001 6196286 6199394 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01013254001 6196286 6199394 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01013254001 6196286 6199394 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01013254001 6196286 6199394 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008357001 2900282 2907002 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01008357001 2900282 2907002 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01008357001 2900282 2907002 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008357001 2900282 2907002 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006242001 23931272 23931454 GSVIVG01027543001 15882269 15885257 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01027543001 15882269 15885257 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01027543001 15882269 15885257 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01027543001 15882269 15885257 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01037945001 11360027 11362116 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA GSVIVG01037945001 11360027 11362116 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GSVIVG01018104001 6575875 6586571 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01018104001 6575875 6586571 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01011843001 3698336 3709017 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nucleotidyl group to a reactant. IEA GO:0016779 nucleotidyltransferase activity GSVIVG01019018001 17682215 17686563 GO:0006464 protein modification process The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019018001 17682215 17686563 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019018001 17682215 17686563 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019018001 17682215 17686563 GO:0006464 protein modification process The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). IEA Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. IEA GO:0016881 acid-amino acid ligase activity GSVIVG01019018001 17682215 17686563 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. IEA GO:0016881 acid-amino acid ligase activity GSVIVG01019018001 17682215 17686563 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. IEA GO:0016881 acid-amino acid ligase activity GSVIVG01019018001 17682215 17686563 GO:0006464 protein modification process The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01019018001 17682215 17686563 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01019018001 17682215 17686563 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01031045001 21416708 21418682 GSVIVG01038144001 23827252 23863361 GSVIVG01014938001 12392274 12392915 GSVIVG01033937001 16581910 16588393 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01033937001 16581910 16588393 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01033937001 16581910 16588393 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01029745001 14045506 14058187 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GSVIVG01021550001 6940079 6943509 GSVIVG01033596001 19445249 19447201 GSVIVG01018890001 18902110 18934303 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01018890001 18902110 18934303 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018890001 18902110 18934303 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01005218001 19308691 19309641 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01031504001 17866116 17866499 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01031504001 17866116 17866499 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01026826001 20152817 20157975 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026826001 20152817 20157975 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026826001 20152817 20157975 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026826001 20152817 20157975 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026826001 20152817 20157975 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026826001 20152817 20157975 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026826001 20152817 20157975 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01026826001 20152817 20157975 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01026826001 20152817 20157975 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01026826001 20152817 20157975 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01026826001 20152817 20157975 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01026826001 20152817 20157975 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01035122001 1620965 1622613 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of arsenite from one side of a membrane to the other. IEA GO:0015105 arsenite transmembrane transporter activity GSVIVG01035122001 1620965 1622613 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of arsenite from one side of a membrane to the other. IEA GO:0015105 arsenite transmembrane transporter activity GSVIVG01035122001 1620965 1622613 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of arsenite from one side of a membrane to the other. IEA GO:0015105 arsenite transmembrane transporter activity GSVIVG01035122001 1620965 1622613 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of arsenite from one side of a membrane to the other. IEA GO:0015105 arsenite transmembrane transporter activity GSVIVG01035122001 1620965 1622613 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01035122001 1620965 1622613 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01035122001 1620965 1622613 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01035122001 1620965 1622613 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01035122001 1620965 1622613 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01035122001 1620965 1622613 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01035122001 1620965 1622613 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01035122001 1620965 1622613 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01008464001 1714388 1715151 GSVIVG01037344001 15391215 15393158 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the reaction: pectin + n H2O = n methanol + pectate. IEA GO:0030599 pectinesterase activity GSVIVG01001649001 21778406 21781126 GSVIVG01032848001 273277 293652 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01032848001 273277 293652 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01032848001 273277 293652 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032848001 273277 293652 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036207001 9035397 9042507 GSVIVG01021276001 3306300 3307545 GSVIVG01000816001 495534 525800 GSVIVG01004463001 38678222 38678398 GSVIVG01015549001 4753254 4787694 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01015549001 4753254 4787694 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01015549001 4753254 4787694 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01015549001 4753254 4787694 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01015549001 4753254 4787694 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01015549001 4753254 4787694 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01015549001 4753254 4787694 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01015549001 4753254 4787694 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01015549001 4753254 4787694 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015549001 4753254 4787694 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015549001 4753254 4787694 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01015549001 4753254 4787694 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01015549001 4753254 4787694 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01015549001 4753254 4787694 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01006635001 27186295 27189650 GSVIVG01033701001 18490721 18496879 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01022306001 18383556 18384104 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01022306001 18383556 18384104 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01026462001 23153007 23156975 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01026462001 23153007 23156975 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01026462001 23153007 23156975 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01026462001 23153007 23156975 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01026462001 23153007 23156975 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01026462001 23153007 23156975 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01026462001 23153007 23156975 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026462001 23153007 23156975 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024694001 7667663 7669004 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. IEA GO:0008080 N-acetyltransferase activity GSVIVG01035233001 10905015 10909860 GO:0009664 plant-type cell wall organization A process that results in the assembly and arrangement of constituent parts of the cellulose and pectin-containing cell wall, or in the disassembly of the cellulose and pectin-containing cell wall. This process is carried out at the cellular level. An example of this process is found in Arabidopsis thaliana. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA GSVIVG01035233001 10905015 10909860 GO:0019953 sexual reproduction The regular alternation, in the life cycle of haplontic, diplontic and diplohaplontic organisms, of meiosis and fertilization which provides for the production offspring. In diplontic organisms there is a life cycle in which the products of meiosis behave directly as gametes, fusing to form a zygote from which the diploid, or sexually reproductive polyploid, adult organism will develop. In diplohaplontic organisms a haploid phase (gametophyte) exists in the life cycle between meiosis and fertilization (e.g. higher plants, many algae and Fungi); the products of meiosis are spores that develop as haploid individuals from which haploid gametes develop to form a diploid zygote; diplohaplontic organisms show an alternation of haploid and diploid generations. In haplontic organisms meiosis occurs in the zygote, giving rise to four haploid cells (e.g. many algae and protozoa), only the zygote is diploid and this may form a resistant spore, tiding organisms over hard times. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA GSVIVG01016445001 3845018 3848534 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01016445001 3845018 3848534 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01016445001 3845018 3848534 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01016445001 3845018 3848534 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01037831001 7412393 7415825 GSVIVG01032057001 23137304 23140938 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01032057001 23137304 23140938 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. IEA GO:0008173 RNA methyltransferase activity GSVIVG01024014001 1740700 1746162 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01010789001 22606844 22611712 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01017412001 8107508 8107831 GSVIVG01033774001 17965628 17967061 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01033774001 17965628 17967061 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01033774001 17965628 17967061 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01033774001 17965628 17967061 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01033774001 17965628 17967061 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01033774001 17965628 17967061 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01021286001 3464257 3493620 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01021286001 3464257 3493620 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01021286001 3464257 3493620 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01021286001 3464257 3493620 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01021286001 3464257 3493620 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015598001 5375945 5377407 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01015598001 5375945 5377407 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01030456001 5704769 5720784 GSVIVG01014605001 5547677 5560992 GSVIVG01024971001 5604195 5609217 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01022728001 15717983 15718087 GSVIVG01030570001 6825578 6832825 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01000227001 16265282 16267397 GSVIVG01037230001 17147303 17205751 GO:0016070 RNA metabolic process The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01037230001 17147303 17205751 GO:0016070 RNA metabolic process The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032922001 24159695 24204470 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032922001 24159695 24204470 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the endohydrolysis of 1,4-alpha-D-glucosidic linkages in polysaccharides containing three or more 1,4-alpha-linked D-glucose units. IEA GO:0004556 alpha-amylase activity GSVIVG01032922001 24159695 24204470 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01032922001 24159695 24204470 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01005189001 18991048 18993638 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01005189001 18991048 18993638 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01035021001 940974 957385 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01009799001 11335660 11337653 GSVIVG01006889001 28888657 28893380 GSVIVG01016067001 18284173 18284391 GSVIVG01030703001 13957988 14049816 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024450001 2734985 2737116 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: ATP + shikimate = ADP + shikimate 3-phosphate. IEA GO:0004765 shikimate kinase activity GSVIVG01024450001 2734985 2737116 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024450001 2734985 2737116 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01017037001 3682815 3686303 GSVIVG01028380001 6844159 6845397 GSVIVG01017756001 3179044 3181240 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01017756001 3179044 3181240 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01003841001 20599725 20603686 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01003841001 20599725 20603686 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Catalysis of the transfer of a nucleotidyl group to a reactant. IEA GO:0016779 nucleotidyltransferase activity GSVIVG01038151001 23903946 23911052 GSVIVG01028141001 4152503 4157352 GSVIVG01020319001 21410608 21416816 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with transfer RNA. IEA GO:0000049 tRNA binding GSVIVG01020319001 21410608 21416816 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe). IEA GO:0004826 phenylalanine-tRNA ligase activity GSVIVG01020319001 21410608 21416816 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013355001 1039270 1054180 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01013355001 1039270 1054180 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01013355001 1039270 1054180 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01013355001 1039270 1054180 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01026101001 24574674 24579669 GSVIVG01018418001 9349201 9353094 GSVIVG01037476001 13008870 13012584 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01034555001 19526362 19539811 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01034555001 19526362 19539811 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01034555001 19526362 19539811 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01021662001 8903917 8907377 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01021662001 8903917 8907377 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01021662001 8903917 8907377 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01021662001 8903917 8907377 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021404001 4955669 5013956 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. IEA GO:0005096 GTPase activator activity GSVIVG01021404001 4955669 5013956 GO:0009250 glucan biosynthetic process The chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues. IEA Increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. IEA GO:0005096 GTPase activator activity GSVIVG01021404001 4955669 5013956 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation. IEA GO:0008083 growth factor activity GSVIVG01021404001 4955669 5013956 GO:0009250 glucan biosynthetic process The chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues. IEA The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation. IEA GO:0008083 growth factor activity GSVIVG01021404001 4955669 5013956 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: ADP-glucose + (1,4)-alpha-D-glucosyl(n) = ADP + (1,4)-alpha-D-glucosyl(n+1). IEA GO:0009011 starch synthase activity GSVIVG01021404001 4955669 5013956 GO:0009250 glucan biosynthetic process The chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues. IEA Catalysis of the reaction: ADP-glucose + (1,4)-alpha-D-glucosyl(n) = ADP + (1,4)-alpha-D-glucosyl(n+1). IEA GO:0009011 starch synthase activity GSVIVG01021379001 4659243 4669920 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01021379001 4659243 4669920 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01020120001 10164110 10164993 GSVIVG01016429001 3999431 4007100 GSVIVG01015219001 1903505 1905244 GSVIVG01000268001 20754604 20827306 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01000268001 20754604 20827306 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01000268001 20754604 20827306 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01000268001 20754604 20827306 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01035981001 6786214 6792883 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01035981001 6786214 6792883 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01035981001 6786214 6792883 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: 2 glutathione + H2O2 = oxidized glutathione + 2 H2O. IEA GO:0004602 glutathione peroxidase activity GSVIVG01035981001 6786214 6792883 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2 glutathione + H2O2 = oxidized glutathione + 2 H2O. IEA GO:0004602 glutathione peroxidase activity GSVIVG01035981001 6786214 6792883 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01035981001 6786214 6792883 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031645001 19561953 19570171 GSVIVG01027510001 16098026 16109678 GSVIVG01024925001 5973296 5977279 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01024925001 5973296 5977279 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01024925001 5973296 5977279 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01024925001 5973296 5977279 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01021695001 9715378 9715662 GSVIVG01014131001 655789 657245 GSVIVG01014816001 10110447 10113213 GSVIVG01001678001 14204584 14205216 GSVIVG01034035001 15682406 15687298 GSVIVG01009334001 7519686 7520846 GSVIVG01034276001 13929719 13959012 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031840001 4798768 4800935 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01031840001 4798768 4800935 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01019419001 512163 513533 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01019419001 512163 513533 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01033994001 16034549 16040052 GSVIVG01025881001 27514537 27525652 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025881001 27514537 27525652 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01025881001 27514537 27525652 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025881001 27514537 27525652 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01025881001 27514537 27525652 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01025881001 27514537 27525652 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01009544001 9238035 9246098 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA GSVIVG01009544001 9238035 9246098 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GSVIVG01017336001 6852097 6856673 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01017336001 6852097 6856673 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017336001 6852097 6856673 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01017336001 6852097 6856673 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01028761001 19120410 19123943 GSVIVG01022523001 4325760 4326629 GSVIVG01001268001 4851663 4855934 GSVIVG01038575001 21758099 21763009 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01038575001 21758099 21763009 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01029460001 22603668 22613667 GSVIVG01018560001 13378319 13382537 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01018560001 13378319 13382537 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01018560001 13378319 13382537 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01018560001 13378319 13382537 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01015262001 2177674 2178341 GSVIVG01032086001 22857538 22879636 GO:0006278 RNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01032086001 22857538 22879636 GO:0006278 RNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the extension of the 3' end of a DNA strand by one deoxynucleotide at a time. Cannot initiate a chain de novo; uses the RNA subunit of the telomerase enzyme complex as its template. IEA GO:0003721 telomeric template RNA reverse transcriptase activity GSVIVG01032086001 22857538 22879636 GO:0006278 RNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01032086001 22857538 22879636 GO:0006278 RNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time. IEA GO:0003964 RNA-directed DNA polymerase activity GSVIVG01014790001 9756852 9758439 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01019544001 1482108 1488349 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01022236001 17746944 17751135 GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA GSVIVG01018037001 5725671 5726108 GSVIVG01025513001 111926 120245 GSVIVG01018456001 14823445 14826786 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01018456001 14823445 14826786 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01018456001 14823445 14826786 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018456001 14823445 14826786 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the two-stage endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides with 2',3'-cyclic phosphate intermediates. IEA GO:0033897 ribonuclease T2 activity GSVIVG01005029001 17327712 17333216 GSVIVG01027014001 18569969 18570865 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027014001 18569969 18570865 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01027014001 18569969 18570865 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01022888001 18325476 18329174 GSVIVG01030395001 5196855 5198820 GSVIVG01037560001 11421450 11425494 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01037560001 11421450 11425494 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01037560001 11421450 11425494 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01037560001 11421450 11425494 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01037560001 11421450 11425494 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01037560001 11421450 11425494 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01018111001 6635387 6637839 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01017075001 4002156 4004102 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033748001 18147298 18157170 GO:0006221 pyrimidine nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-glutamate = ADP + L-glutamate 5-phosphate. IEA GO:0004349 glutamate 5-kinase activity GSVIVG01033748001 18147298 18157170 GO:0006561 proline biosynthetic process The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-glutamate = ADP + L-glutamate 5-phosphate. IEA GO:0004349 glutamate 5-kinase activity GSVIVG01033748001 18147298 18157170 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-glutamate = ADP + L-glutamate 5-phosphate. IEA GO:0004349 glutamate 5-kinase activity GSVIVG01033748001 18147298 18157170 GO:0006221 pyrimidine nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + UMP = ADP + UDP. IEA GO:0033862 UMP kinase activity GSVIVG01033748001 18147298 18157170 GO:0006561 proline biosynthetic process The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + UMP = ADP + UDP. IEA GO:0033862 UMP kinase activity GSVIVG01033748001 18147298 18157170 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + UMP = ADP + UDP. IEA GO:0033862 UMP kinase activity GSVIVG01022083001 16448284 16459427 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01000791001 184543 190834 GSVIVG01032380001 26830865 26837199 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032380001 26830865 26837199 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01026980001 18867546 18870026 GSVIVG01000874001 3067143 3079488 GSVIVG01018872001 19069129 19069734 GSVIVG01011390001 29283073 29288997 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01015653001 14993698 14993826 GSVIVG01029054001 11503639 11518716 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01029054001 11503639 11518716 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01029054001 11503639 11518716 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01028601001 10473600 10474690 GSVIVG01019342001 776418 776531 GSVIVG01008476001 1537423 1538551 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01008476001 1537423 1538551 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01008476001 1537423 1538551 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01008476001 1537423 1538551 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033074001 25557680 25557889 GSVIVG01023556001 9715660 9716247 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023556001 9715660 9716247 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014437001 3749995 3776743 GO:0016459 myosin complex A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01014437001 3749995 3776743 GO:0016459 myosin complex A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. IEA Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate. IEA GO:0003774 motor activity GSVIVG01014437001 3749995 3776743 GO:0016459 myosin complex A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014437001 3749995 3776743 GO:0016459 myosin complex A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01009861001 11893639 11897902 GSVIVG01022727001 15684005 15686062 GSVIVG01020320001 21399795 21403434 GSVIVG01023131001 22263568 22270055 GO:0008299 isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01005096001 14494569 14495486 GSVIVG01035789001 4352129 4353580 GSVIVG01010251001 18351868 18371377 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01010251001 18351868 18371377 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01010251001 18351868 18371377 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate, driving the unwinding of the DNA helix. IEA GO:0004003 ATP-dependent DNA helicase activity GSVIVG01010251001 18351868 18371377 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010251001 18351868 18371377 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01010251001 18351868 18371377 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01019435001 674198 674380 GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA GSVIVG01014099001 374955 375178 GSVIVG01029994001 8777106 8784401 GSVIVG01014326001 2673118 2682722 GSVIVG01033588001 19489477 19499273 GO:0006561 proline biosynthetic process The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033588001 19489477 19499273 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033588001 19489477 19499273 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033588001 19489477 19499273 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033588001 19489477 19499273 GO:0006561 proline biosynthetic process The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: L-proline + NADP+ = 1-pyrroline-5-carboxylate + NADPH + H+. IEA GO:0004735 pyrroline-5-carboxylate reductase activity GSVIVG01033588001 19489477 19499273 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: L-proline + NADP+ = 1-pyrroline-5-carboxylate + NADPH + H+. IEA GO:0004735 pyrroline-5-carboxylate reductase activity GSVIVG01033588001 19489477 19499273 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: L-proline + NADP+ = 1-pyrroline-5-carboxylate + NADPH + H+. IEA GO:0004735 pyrroline-5-carboxylate reductase activity GSVIVG01033588001 19489477 19499273 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: L-proline + NADP+ = 1-pyrroline-5-carboxylate + NADPH + H+. IEA GO:0004735 pyrroline-5-carboxylate reductase activity GSVIVG01033588001 19489477 19499273 GO:0006561 proline biosynthetic process The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033588001 19489477 19499273 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033588001 19489477 19499273 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033588001 19489477 19499273 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033588001 19489477 19499273 GO:0006561 proline biosynthetic process The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01033588001 19489477 19499273 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01033588001 19489477 19499273 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01033588001 19489477 19499273 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01033588001 19489477 19499273 GO:0006561 proline biosynthetic process The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01033588001 19489477 19499273 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01033588001 19489477 19499273 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01033588001 19489477 19499273 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01030200001 10572426 10589939 GSVIVG01016999001 3328286 3336959 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016999001 3328286 3336959 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01016999001 3328286 3336959 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01016999001 3328286 3336959 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016999001 3328286 3336959 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01016999001 3328286 3336959 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01024600001 8542818 8545255 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01024600001 8542818 8545255 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01024600001 8542818 8545255 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01024600001 8542818 8545255 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01024600001 8542818 8545255 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024600001 8542818 8545255 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024600001 8542818 8545255 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01024600001 8542818 8545255 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01024600001 8542818 8545255 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01024600001 8542818 8545255 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01017136001 4497203 4509529 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01017136001 4497203 4509529 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01017136001 4497203 4509529 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017136001 4497203 4509529 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017136001 4497203 4509529 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01017136001 4497203 4509529 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01017136001 4497203 4509529 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01017136001 4497203 4509529 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01013336001 12285036 12308837 GO:0007205 activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway The initiation of the activity of the inactive enzyme protein kinase C as the result of a series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol 3-phosphate. IEA GO:0004143 diacylglycerol kinase activity GSVIVG01009425001 8244437 8245150 GSVIVG01008774001 1835240 1835677 GSVIVG01024119001 930890 960586 GO:0009086 methionine biosynthetic process The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. IEA Catalysis of the reaction: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine. IEA GO:0003871 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity GSVIVG01024119001 930890 960586 GO:0009086 methionine biosynthetic process The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01020404001 19972384 19975720 Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01020404001 19972384 19975720 Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01027788001 7779514 7784012 GSVIVG01028682001 12042352 12043393 GSVIVG01025102001 4475885 4484503 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025102001 4475885 4484503 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01025102001 4475885 4484503 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025102001 4475885 4484503 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01025102001 4475885 4484503 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01026936001 19246285 19253749 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01026936001 19246285 19253749 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01026936001 19246285 19253749 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01026936001 19246285 19253749 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01026936001 19246285 19253749 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01026936001 19246285 19253749 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01026936001 19246285 19253749 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01026936001 19246285 19253749 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01026936001 19246285 19253749 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01026936001 19246285 19253749 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01026936001 19246285 19253749 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026936001 19246285 19253749 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022645001 14032865 14036930 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012112001 1340900 1343491 GSVIVG01012875001 6431171 6446791 GSVIVG01031841001 4802389 4802910 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01031841001 4802389 4802910 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the synthesis of a short RNA primer on a DNA template, providing a free 3'-OH that can be extended by DNA-directed DNA polymerases. Catalyzed by a DNA-directed RNA polymerase that forms a complex with alpha DNA polymerase. IEA GO:0003896 DNA primase activity GSVIVG01031841001 4802389 4802910 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01031841001 4802389 4802910 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01010091001 15229260 15243545 GO:0009073 aromatic amino acid family biosynthetic process The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). IEA Catalysis of the reaction: chorismate = prephenate. IEA GO:0004106 chorismate mutase activity GSVIVG01010091001 15229260 15243545 GO:0046417 chorismate metabolic process The chemical reactions and pathways involving chorismate, the anion of (3R-trans)-3-((1-carboxyethenyl)oxy)-4-hydroxy-1,5-cyclohexadiene-1-carboxylic acid. IEA Catalysis of the reaction: chorismate = prephenate. IEA GO:0004106 chorismate mutase activity GSVIVG01036469001 22411832 22425883 GSVIVG01030020001 8975020 8979835 GSVIVG01022404001 19734179 19751874 GSVIVG01013603001 1166948 1167390 GSVIVG01000164001 15798066 15799979 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01005168001 18906284 18912195 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01005168001 18906284 18912195 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01005168001 18906284 18912195 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01005168001 18906284 18912195 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021236001 2856549 2860861 GSVIVG01010650001 15621697 15623941 GO:0006066 alcohol metabolic process The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GSVIVG01010650001 15621697 15623941 GO:0006066 alcohol metabolic process The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01038556001 21853425 21867415 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01038556001 21853425 21867415 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01007621001 11153636 11159809 GO:0009435 NAD biosynthetic process The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH. IEA Catalysis of the reaction: iminoaspartate + dihydroxy-acetone-phosphate = quinolinate + 2 H2O + phosphate. IEA GO:0008987 quinolinate synthetase A activity GSVIVG01028239001 4871414 4874278 GSVIVG01026242001 14711691 14713871 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01026242001 14711691 14713871 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01026242001 14711691 14713871 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01026242001 14711691 14713871 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01026242001 14711691 14713871 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01026242001 14711691 14713871 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01026242001 14711691 14713871 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01026242001 14711691 14713871 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01026242001 14711691 14713871 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01026242001 14711691 14713871 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01026242001 14711691 14713871 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01026242001 14711691 14713871 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01026242001 14711691 14713871 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026242001 14711691 14713871 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026242001 14711691 14713871 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026242001 14711691 14713871 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026242001 14711691 14713871 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026242001 14711691 14713871 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026242001 14711691 14713871 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026242001 14711691 14713871 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026242001 14711691 14713871 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026242001 14711691 14713871 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026242001 14711691 14713871 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026242001 14711691 14713871 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01023687001 9287826 9323652 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004185 serine-type carboxypeptidase activity GSVIVG01016988001 3205112 3219645 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016988001 3205112 3219645 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. IEA GO:0004722 protein serine/threonine phosphatase activity GSVIVG01018835001 19448561 19450492 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01002619001 35416684 35420469 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01002619001 35416684 35420469 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01002619001 35416684 35420469 Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01028114001 3908332 3913910 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01028114001 3908332 3913910 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01031246001 852709 855754 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01018946001 18456922 18459114 GSVIVG01009067001 4659693 4663337 GSVIVG01037255001 16879472 16882230 GSVIVG01010061001 14402385 14405941 GSVIVG01009937001 12608249 12608970 GSVIVG01012771001 23528929 23531125 GSVIVG01006270001 24379898 24384550 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. IEA GO:0004725 protein tyrosine phosphatase activity GSVIVG01006270001 24379898 24384550 GO:0016311 dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. IEA Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. IEA GO:0004725 protein tyrosine phosphatase activity GSVIVG01006270001 24379898 24384550 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA Catalysis of the reaction: protein serine/threonine/tyrosine phosphate + H2O = protein serine/threonine/tyrosine + phosphate. IEA GO:0008138 protein tyrosine/serine/threonine phosphatase activity GSVIVG01006270001 24379898 24384550 GO:0016311 dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. IEA Catalysis of the reaction: protein serine/threonine/tyrosine phosphate + H2O = protein serine/threonine/tyrosine + phosphate. IEA GO:0008138 protein tyrosine/serine/threonine phosphatase activity GSVIVG01006270001 24379898 24384550 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. IEA GO:0016791 phosphatase activity GSVIVG01006270001 24379898 24384550 GO:0016311 dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. IEA Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. IEA GO:0016791 phosphatase activity GSVIVG01000109001 15344499 15345968 GSVIVG01028075001 3628217 3629013 GSVIVG01008766001 1791337 1803062 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA GSVIVG01010115001 15722218 15727580 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01021381001 4672999 4683341 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01021381001 4672999 4683341 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01021381001 4672999 4683341 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01021381001 4672999 4683341 GO:0007600 sensory perception The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01021381001 4672999 4683341 GO:0009585 red, far-red light phototransduction The sequence of reactions within a cell required to convert absorbed photons from red or far-red light into a molecular signal; the red, far-red light range is defined as having a wavelength within the range 660-730 nm. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01021381001 4672999 4683341 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01021381001 4672999 4683341 GO:0017006 protein-tetrapyrrole linkage The covalent linking of a tetrapyrrole to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01021381001 4672999 4683341 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01021381001 4672999 4683341 GO:0018298 protein-chromophore linkage The covalent or noncovalent linking of a chromophore to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01021381001 4672999 4683341 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01021381001 4672999 4683341 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01021381001 4672999 4683341 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01021381001 4672999 4683341 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01021381001 4672999 4683341 GO:0007600 sensory perception The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01021381001 4672999 4683341 GO:0009585 red, far-red light phototransduction The sequence of reactions within a cell required to convert absorbed photons from red or far-red light into a molecular signal; the red, far-red light range is defined as having a wavelength within the range 660-730 nm. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01021381001 4672999 4683341 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01021381001 4672999 4683341 GO:0017006 protein-tetrapyrrole linkage The covalent linking of a tetrapyrrole to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01021381001 4672999 4683341 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01021381001 4672999 4683341 GO:0018298 protein-chromophore linkage The covalent or noncovalent linking of a chromophore to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01021381001 4672999 4683341 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01021381001 4672999 4683341 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01021381001 4672999 4683341 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01021381001 4672999 4683341 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01021381001 4672999 4683341 GO:0007600 sensory perception The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01021381001 4672999 4683341 GO:0009585 red, far-red light phototransduction The sequence of reactions within a cell required to convert absorbed photons from red or far-red light into a molecular signal; the red, far-red light range is defined as having a wavelength within the range 660-730 nm. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01021381001 4672999 4683341 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01021381001 4672999 4683341 GO:0017006 protein-tetrapyrrole linkage The covalent linking of a tetrapyrrole to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01021381001 4672999 4683341 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01021381001 4672999 4683341 GO:0018298 protein-chromophore linkage The covalent or noncovalent linking of a chromophore to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01021381001 4672999 4683341 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01021381001 4672999 4683341 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01021381001 4672999 4683341 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01021381001 4672999 4683341 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01021381001 4672999 4683341 GO:0007600 sensory perception The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01021381001 4672999 4683341 GO:0009585 red, far-red light phototransduction The sequence of reactions within a cell required to convert absorbed photons from red or far-red light into a molecular signal; the red, far-red light range is defined as having a wavelength within the range 660-730 nm. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01021381001 4672999 4683341 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01021381001 4672999 4683341 GO:0017006 protein-tetrapyrrole linkage The covalent linking of a tetrapyrrole to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01021381001 4672999 4683341 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01021381001 4672999 4683341 GO:0018298 protein-chromophore linkage The covalent or noncovalent linking of a chromophore to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01021381001 4672999 4683341 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01021381001 4672999 4683341 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021381001 4672999 4683341 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021381001 4672999 4683341 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021381001 4672999 4683341 GO:0007600 sensory perception The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021381001 4672999 4683341 GO:0009585 red, far-red light phototransduction The sequence of reactions within a cell required to convert absorbed photons from red or far-red light into a molecular signal; the red, far-red light range is defined as having a wavelength within the range 660-730 nm. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021381001 4672999 4683341 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021381001 4672999 4683341 GO:0017006 protein-tetrapyrrole linkage The covalent linking of a tetrapyrrole to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021381001 4672999 4683341 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021381001 4672999 4683341 GO:0018298 protein-chromophore linkage The covalent or noncovalent linking of a chromophore to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021381001 4672999 4683341 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021381001 4672999 4683341 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A G-protein coupled receptor that responds to incidental electromagnetic radiation, particularly visible light. IEA GO:0008020 G-protein coupled photoreceptor activity GSVIVG01021381001 4672999 4683341 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A G-protein coupled receptor that responds to incidental electromagnetic radiation, particularly visible light. IEA GO:0008020 G-protein coupled photoreceptor activity GSVIVG01021381001 4672999 4683341 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A G-protein coupled receptor that responds to incidental electromagnetic radiation, particularly visible light. IEA GO:0008020 G-protein coupled photoreceptor activity GSVIVG01021381001 4672999 4683341 GO:0007600 sensory perception The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A G-protein coupled receptor that responds to incidental electromagnetic radiation, particularly visible light. IEA GO:0008020 G-protein coupled photoreceptor activity GSVIVG01021381001 4672999 4683341 GO:0009585 red, far-red light phototransduction The sequence of reactions within a cell required to convert absorbed photons from red or far-red light into a molecular signal; the red, far-red light range is defined as having a wavelength within the range 660-730 nm. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A G-protein coupled receptor that responds to incidental electromagnetic radiation, particularly visible light. IEA GO:0008020 G-protein coupled photoreceptor activity GSVIVG01021381001 4672999 4683341 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A G-protein coupled receptor that responds to incidental electromagnetic radiation, particularly visible light. IEA GO:0008020 G-protein coupled photoreceptor activity GSVIVG01021381001 4672999 4683341 GO:0017006 protein-tetrapyrrole linkage The covalent linking of a tetrapyrrole to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A G-protein coupled receptor that responds to incidental electromagnetic radiation, particularly visible light. IEA GO:0008020 G-protein coupled photoreceptor activity GSVIVG01021381001 4672999 4683341 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A G-protein coupled receptor that responds to incidental electromagnetic radiation, particularly visible light. IEA GO:0008020 G-protein coupled photoreceptor activity GSVIVG01021381001 4672999 4683341 GO:0018298 protein-chromophore linkage The covalent or noncovalent linking of a chromophore to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A G-protein coupled receptor that responds to incidental electromagnetic radiation, particularly visible light. IEA GO:0008020 G-protein coupled photoreceptor activity GSVIVG01021381001 4672999 4683341 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A G-protein coupled receptor that responds to incidental electromagnetic radiation, particularly visible light. IEA GO:0008020 G-protein coupled photoreceptor activity GSVIVG01021381001 4672999 4683341 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation. IEA GO:0009881 photoreceptor activity GSVIVG01021381001 4672999 4683341 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation. IEA GO:0009881 photoreceptor activity GSVIVG01021381001 4672999 4683341 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation. IEA GO:0009881 photoreceptor activity GSVIVG01021381001 4672999 4683341 GO:0007600 sensory perception The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation. IEA GO:0009881 photoreceptor activity GSVIVG01021381001 4672999 4683341 GO:0009585 red, far-red light phototransduction The sequence of reactions within a cell required to convert absorbed photons from red or far-red light into a molecular signal; the red, far-red light range is defined as having a wavelength within the range 660-730 nm. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation. IEA GO:0009881 photoreceptor activity GSVIVG01021381001 4672999 4683341 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation. IEA GO:0009881 photoreceptor activity GSVIVG01021381001 4672999 4683341 GO:0017006 protein-tetrapyrrole linkage The covalent linking of a tetrapyrrole to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation. IEA GO:0009881 photoreceptor activity GSVIVG01021381001 4672999 4683341 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation. IEA GO:0009881 photoreceptor activity GSVIVG01021381001 4672999 4683341 GO:0018298 protein-chromophore linkage The covalent or noncovalent linking of a chromophore to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation. IEA GO:0009881 photoreceptor activity GSVIVG01021381001 4672999 4683341 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation. IEA GO:0009881 photoreceptor activity GSVIVG01021381001 4672999 4683341 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01021381001 4672999 4683341 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01021381001 4672999 4683341 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01021381001 4672999 4683341 GO:0007600 sensory perception The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01021381001 4672999 4683341 GO:0009585 red, far-red light phototransduction The sequence of reactions within a cell required to convert absorbed photons from red or far-red light into a molecular signal; the red, far-red light range is defined as having a wavelength within the range 660-730 nm. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01021381001 4672999 4683341 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01021381001 4672999 4683341 GO:0017006 protein-tetrapyrrole linkage The covalent linking of a tetrapyrrole to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01021381001 4672999 4683341 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01021381001 4672999 4683341 GO:0018298 protein-chromophore linkage The covalent or noncovalent linking of a chromophore to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01021381001 4672999 4683341 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01021381001 4672999 4683341 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with an identical protein to form a homodimer. IEA GO:0042803 protein homodimerization activity GSVIVG01021381001 4672999 4683341 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with an identical protein to form a homodimer. IEA GO:0042803 protein homodimerization activity GSVIVG01021381001 4672999 4683341 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with an identical protein to form a homodimer. IEA GO:0042803 protein homodimerization activity GSVIVG01021381001 4672999 4683341 GO:0007600 sensory perception The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with an identical protein to form a homodimer. IEA GO:0042803 protein homodimerization activity GSVIVG01021381001 4672999 4683341 GO:0009585 red, far-red light phototransduction The sequence of reactions within a cell required to convert absorbed photons from red or far-red light into a molecular signal; the red, far-red light range is defined as having a wavelength within the range 660-730 nm. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with an identical protein to form a homodimer. IEA GO:0042803 protein homodimerization activity GSVIVG01021381001 4672999 4683341 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with an identical protein to form a homodimer. IEA GO:0042803 protein homodimerization activity GSVIVG01021381001 4672999 4683341 GO:0017006 protein-tetrapyrrole linkage The covalent linking of a tetrapyrrole to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with an identical protein to form a homodimer. IEA GO:0042803 protein homodimerization activity GSVIVG01021381001 4672999 4683341 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with an identical protein to form a homodimer. IEA GO:0042803 protein homodimerization activity GSVIVG01021381001 4672999 4683341 GO:0018298 protein-chromophore linkage The covalent or noncovalent linking of a chromophore to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with an identical protein to form a homodimer. IEA GO:0042803 protein homodimerization activity GSVIVG01021381001 4672999 4683341 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with an identical protein to form a homodimer. IEA GO:0042803 protein homodimerization activity GSVIVG01025699001 12864654 12870921 GSVIVG01007647001 10869022 10874179 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01031780001 4306720 4311753 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01031780001 4306720 4311753 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01027388001 15420452 15421795 GSVIVG01021827001 6801973 6811488 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GSVIVG01028369001 6733544 6739764 GO:0010038 response to metal ion A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus. IEA Catalysis of the reaction: glutathione + Glu(-Cys)(n)-Gly = Gly + Glu(-Cys)(n+1)-Gly. IEA GO:0016756 glutathione gamma-glutamylcysteinyltransferase activity GSVIVG01028369001 6733544 6739764 GO:0046938 phytochelatin biosynthetic process The chemical reactions and pathways resulting in the formation of phytochelatins, any of a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes. The structure is of the type (gamma-glutamyl-cysteinyl)n-glycine, where n is 2 to 11. IEA Catalysis of the reaction: glutathione + Glu(-Cys)(n)-Gly = Gly + Glu(-Cys)(n+1)-Gly. IEA GO:0016756 glutathione gamma-glutamylcysteinyltransferase activity GSVIVG01028369001 6733544 6739764 GO:0010038 response to metal ion A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01028369001 6733544 6739764 GO:0046938 phytochelatin biosynthetic process The chemical reactions and pathways resulting in the formation of phytochelatins, any of a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes. The structure is of the type (gamma-glutamyl-cysteinyl)n-glycine, where n is 2 to 11. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01030715001 14450436 14451168 GSVIVG01018076001 6247177 6257664 GSVIVG01003781001 12637034 12638959 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003781001 12637034 12638959 Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01027854001 8668794 8672743 GSVIVG01031877001 5052307 5052789 GSVIVG01020562001 4313914 4316030 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate. IEA GO:0004629 phospholipase C activity GSVIVG01020562001 4313914 4316030 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate. IEA GO:0004629 phospholipase C activity GSVIVG01020562001 4313914 4316030 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01020562001 4313914 4316030 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01007344001 31458620 31460692 GSVIVG01031103001 2273667 2274231 GSVIVG01024279001 504576 508957 Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01024279001 504576 508957 Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01024279001 504576 508957 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01024279001 504576 508957 Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01009762001 11070661 11090733 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01009762001 11070661 11090733 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01009762001 11070661 11090733 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01009762001 11070661 11090733 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01008072001 6061886 6063576 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01001864001 226946 247509 GSVIVG01030505001 6277163 6280131 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01009318001 7324243 7332148 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01030038001 9055263 9068023 GSVIVG01030419001 5427894 5430712 GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Prevents the dissociation of GDP from the small GTPase Rho, thereby preventing GTP from binding. IEA GO:0005094 Rho GDP-dissociation inhibitor activity GSVIVG01014732001 9054784 9058957 GSVIVG01024117001 967527 969830 GSVIVG01023816001 3239810 3255189 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01018524001 13818127 13819671 GSVIVG01017552001 10463188 10473531 GSVIVG01011766001 4359602 4363135 GSVIVG01000552001 7179039 7188209 GSVIVG01026000001 26025915 26031969 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01026000001 26025915 26031969 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01026000001 26025915 26031969 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01026000001 26025915 26031969 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01026000001 26025915 26031969 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019717001 2708196 2718224 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019717001 2708196 2718224 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01006497001 42340200 42341861 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01006497001 42340200 42341861 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01028484001 8189434 8212529 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01012639001 256137 258276 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Stops, prevents or reduces the activity of an enzyme. IEA GO:0004857 enzyme inhibitor activity GSVIVG01012639001 256137 258276 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the reaction: pectin + n H2O = n methanol + pectate. IEA GO:0030599 pectinesterase activity GSVIVG01011820001 3854482 3857650 GSVIVG01006716001 27744340 27745418 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion. IEA GO:0005484 SNAP receptor activity GSVIVG01006716001 27744340 27745418 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion. IEA GO:0005484 SNAP receptor activity GSVIVG01006716001 27744340 27745418 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01006716001 27744340 27745418 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01010009001 13418282 13429828 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01010009001 13418282 13429828 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end. IEA GO:0004527 exonuclease activity GSVIVG01019165001 15777315 15779531 GSVIVG01021514001 6456017 6457306 GSVIVG01038118001 23602082 23602877 GSVIVG01028653001 11636036 11638184 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01028653001 11636036 11638184 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01028653001 11636036 11638184 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01028653001 11636036 11638184 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01002731001 36225069 36235771 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024286001 547607 554514 GSVIVG01026162001 13229740 13235618 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01026162001 13229740 13235618 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01026162001 13229740 13235618 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026162001 13229740 13235618 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026162001 13229740 13235618 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01026162001 13229740 13235618 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01024305001 699979 702603 GO:0006559 L-phenylalanine catabolic process The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024305001 699979 702603 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024305001 699979 702603 GO:0006559 L-phenylalanine catabolic process The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of ammonia (NH3) to another substance via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. IEA GO:0016211 ammonia ligase activity GSVIVG01024305001 699979 702603 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of ammonia (NH3) to another substance via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. IEA GO:0016211 ammonia ligase activity GSVIVG01024305001 699979 702603 GO:0006559 L-phenylalanine catabolic process The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate. IEA GO:0016841 ammonia-lyase activity GSVIVG01024305001 699979 702603 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate. IEA GO:0016841 ammonia-lyase activity GSVIVG01019630001 2093246 2099598 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01019630001 2093246 2099598 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01019630001 2093246 2099598 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01019630001 2093246 2099598 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01019630001 2093246 2099598 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01019630001 2093246 2099598 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01019630001 2093246 2099598 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01019630001 2093246 2099598 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01019630001 2093246 2099598 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019630001 2093246 2099598 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019630001 2093246 2099598 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01019630001 2093246 2099598 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01030246001 9914915 9920719 GSVIVG01037089001 29276688 29278041 GSVIVG01017322001 6710092 6711196 GSVIVG01038726001 20562919 20563134 GSVIVG01034772001 21198143 21199088 GSVIVG01033587001 19499319 19503546 GSVIVG01021830001 6781993 6784048 GSVIVG01016881001 2235001 2236355 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. IEA GO:0016791 phosphatase activity GSVIVG01028029001 3291714 3298888 GO:0006471 protein amino acid ADP-ribosylation The transfer, from NAD, of ADP-ribose to protein amino acids. IEA Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor. IEA GO:0003950 NAD+ ADP-ribosyltransferase activity GSVIVG01008881001 3084053 3095775 GSVIVG01035718001 3630778 3637892 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01024408001 2174455 2178843 GSVIVG01023037001 16524280 16552240 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01023037001 16524280 16552240 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01023037001 16524280 16552240 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01023037001 16524280 16552240 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008459001 1776168 1784724 GSVIVG01038561001 21823284 21826992 GSVIVG01017318001 6687564 6688330 GSVIVG01038459001 12799413 12800017 GSVIVG01000010001 2692594 2693228 GSVIVG01026383001 15381841 15382560 GSVIVG01019873001 4110679 4113795 GO:0009308 amine metabolic process The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01019873001 4110679 4113795 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01019873001 4110679 4113795 GO:0009308 amine metabolic process The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. IEA Catalysis of the reaction: R-CH2-NH2 + H2O + O2 = R-CHO + NH3 + H2O2. IEA GO:0008131 amine oxidase activity GSVIVG01019873001 4110679 4113795 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: R-CH2-NH2 + H2O + O2 = R-CHO + NH3 + H2O2. IEA GO:0008131 amine oxidase activity GSVIVG01019873001 4110679 4113795 GO:0009308 amine metabolic process The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. IEA Interacting selectively and non-covalently with a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds. IEA GO:0048038 quinone binding GSVIVG01019873001 4110679 4113795 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds. IEA GO:0048038 quinone binding GSVIVG01035966001 6578504 6598826 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015350001 2881386 2885223 The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01004035001 14415702 14417252 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012856001 6216649 6229005 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01038148001 23891152 23894151 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035298001 176405 181717 GSVIVG01033988001 16063998 16070822 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01028242001 4888167 4889140 The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01026339001 14283235 14286771 GSVIVG01016218001 6501373 6505907 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01016218001 6501373 6505907 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01016218001 6501373 6505907 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01003618001 11315826 11322463 GSVIVG01035022001 964608 973232 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+. IEA GO:0004148 dihydrolipoyl dehydrogenase activity GSVIVG01035022001 964608 973232 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+. IEA GO:0004148 dihydrolipoyl dehydrogenase activity GSVIVG01035022001 964608 973232 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+. IEA GO:0004148 dihydrolipoyl dehydrogenase activity GSVIVG01035022001 964608 973232 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+. IEA GO:0004148 dihydrolipoyl dehydrogenase activity GSVIVG01035022001 964608 973232 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+. IEA GO:0004148 dihydrolipoyl dehydrogenase activity GSVIVG01035022001 964608 973232 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+. IEA GO:0004148 dihydrolipoyl dehydrogenase activity GSVIVG01035022001 964608 973232 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+. IEA GO:0004148 dihydrolipoyl dehydrogenase activity GSVIVG01035022001 964608 973232 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+. IEA GO:0004148 dihydrolipoyl dehydrogenase activity GSVIVG01035022001 964608 973232 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor. IEA GO:0004368 glycerol-3-phosphate dehydrogenase activity GSVIVG01035022001 964608 973232 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor. IEA GO:0004368 glycerol-3-phosphate dehydrogenase activity GSVIVG01035022001 964608 973232 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor. IEA GO:0004368 glycerol-3-phosphate dehydrogenase activity GSVIVG01035022001 964608 973232 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor. IEA GO:0004368 glycerol-3-phosphate dehydrogenase activity GSVIVG01035022001 964608 973232 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor. IEA GO:0004368 glycerol-3-phosphate dehydrogenase activity GSVIVG01035022001 964608 973232 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor. IEA GO:0004368 glycerol-3-phosphate dehydrogenase activity GSVIVG01035022001 964608 973232 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor. IEA GO:0004368 glycerol-3-phosphate dehydrogenase activity GSVIVG01035022001 964608 973232 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor. IEA GO:0004368 glycerol-3-phosphate dehydrogenase activity GSVIVG01035022001 964608 973232 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01035022001 964608 973232 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01035022001 964608 973232 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01035022001 964608 973232 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01035022001 964608 973232 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01035022001 964608 973232 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01035022001 964608 973232 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01035022001 964608 973232 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01035022001 964608 973232 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01035022001 964608 973232 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01035022001 964608 973232 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01035022001 964608 973232 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01035022001 964608 973232 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01035022001 964608 973232 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01035022001 964608 973232 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01035022001 964608 973232 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01028903001 17676678 17678461 GSVIVG01014837001 10399638 10401741 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01014837001 10399638 10401741 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01014837001 10399638 10401741 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the reaction: D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate. IEA GO:0004332 fructose-bisphosphate aldolase activity GSVIVG01014837001 10399638 10401741 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate. IEA GO:0004332 fructose-bisphosphate aldolase activity GSVIVG01014837001 10399638 10401741 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01014837001 10399638 10401741 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01011145001 7213550 7222569 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01026806001 7543843 7547660 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01026806001 7543843 7547660 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01026806001 7543843 7547660 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01026806001 7543843 7547660 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01037329001 15591134 15591873 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01037329001 15591134 15591873 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01037329001 15591134 15591873 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01001983001 6033392 6050001 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GSVIVG01033166001 8831627 8851182 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin. IEA GO:0004221 ubiquitin thiolesterase activity GSVIVG01033166001 8831627 8851182 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01009483001 8745189 8755025 GO:0001510 RNA methylation Posttranscriptional addition of a methyl group to either a nucleotide or 2'-O ribose in a polyribonucleotide. Usually uses S-adenosylmethionine as a cofactor. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01009483001 8745189 8755025 GO:0009452 RNA capping The sequence of enzymatic reactions by which the 5' cap structure, an inverted 7-methylguanosine linked via a 5'-5' triphosphate bridge (m7G(5')ppp(5')X) to the first transcribed residue, is added to a nascent RNA polymerase II transcript. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01009483001 8745189 8755025 GO:0001510 RNA methylation Posttranscriptional addition of a methyl group to either a nucleotide or 2'-O ribose in a polyribonucleotide. Usually uses S-adenosylmethionine as a cofactor. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01009483001 8745189 8755025 GO:0009452 RNA capping The sequence of enzymatic reactions by which the 5' cap structure, an inverted 7-methylguanosine linked via a 5'-5' triphosphate bridge (m7G(5')ppp(5')X) to the first transcribed residue, is added to a nascent RNA polymerase II transcript. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01005209001 19212908 19213815 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01005209001 19212908 19213815 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01005209001 19212908 19213815 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01005209001 19212908 19213815 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01032469001 27711324 27720536 GSVIVG01018735001 20310393 20310911 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01017763001 3244891 3246711 GSVIVG01018677001 11279989 11283599 GSVIVG01011606001 6028424 6029565 GO:0022904 respiratory electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01024782001 6996546 6998308 GSVIVG01008877001 3042409 3045657 GSVIVG01037215001 27912068 27913691 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01037215001 27912068 27913691 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01037215001 27912068 27913691 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01021502001 6283880 6321286 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0031461 cullin-RING ubiquitin ligase complex Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity. IEA Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins. IEA GO:0031625 ubiquitin protein ligase binding GSVIVG01034927001 170510 170794 GSVIVG01008132001 5521945 5526410 GSVIVG01026381001 15364008 15364667 GSVIVG01022938001 17802297 17803337 GSVIVG01004087001 14706826 14709999 GSVIVG01021057001 14365853 14385345 GO:0006621 protein retention in ER lumen The retention in the endoplasmic reticulum (ER) lumen of soluble resident proteins. Sorting receptors retrieve proteins with ER localization signals, such as KDEL and HDEL sequences or some transmembrane domains, that have escaped to the cis-Golgi network and return them to the ER. Abnormally folded proteins and unassembled subunits are also selectively retained in the ER. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01021057001 14365853 14385345 GO:0006621 protein retention in ER lumen The retention in the endoplasmic reticulum (ER) lumen of soluble resident proteins. Sorting receptors retrieve proteins with ER localization signals, such as KDEL and HDEL sequences or some transmembrane domains, that have escaped to the cis-Golgi network and return them to the ER. Abnormally folded proteins and unassembled subunits are also selectively retained in the ER. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01021057001 14365853 14385345 GO:0006621 protein retention in ER lumen The retention in the endoplasmic reticulum (ER) lumen of soluble resident proteins. Sorting receptors retrieve proteins with ER localization signals, such as KDEL and HDEL sequences or some transmembrane domains, that have escaped to the cis-Golgi network and return them to the ER. Abnormally folded proteins and unassembled subunits are also selectively retained in the ER. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01021057001 14365853 14385345 GO:0006621 protein retention in ER lumen The retention in the endoplasmic reticulum (ER) lumen of soluble resident proteins. Sorting receptors retrieve proteins with ER localization signals, such as KDEL and HDEL sequences or some transmembrane domains, that have escaped to the cis-Golgi network and return them to the ER. Abnormally folded proteins and unassembled subunits are also selectively retained in the ER. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01021057001 14365853 14385345 GO:0006621 protein retention in ER lumen The retention in the endoplasmic reticulum (ER) lumen of soluble resident proteins. Sorting receptors retrieve proteins with ER localization signals, such as KDEL and HDEL sequences or some transmembrane domains, that have escaped to the cis-Golgi network and return them to the ER. Abnormally folded proteins and unassembled subunits are also selectively retained in the ER. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an endoplasmic reticulum (ER) retention sequence, a specific peptide sequence that ensures a protein is retained within the ER. IEA GO:0046923 ER retention sequence binding GSVIVG01021057001 14365853 14385345 GO:0006621 protein retention in ER lumen The retention in the endoplasmic reticulum (ER) lumen of soluble resident proteins. Sorting receptors retrieve proteins with ER localization signals, such as KDEL and HDEL sequences or some transmembrane domains, that have escaped to the cis-Golgi network and return them to the ER. Abnormally folded proteins and unassembled subunits are also selectively retained in the ER. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with an endoplasmic reticulum (ER) retention sequence, a specific peptide sequence that ensures a protein is retained within the ER. IEA GO:0046923 ER retention sequence binding GSVIVG01024811001 6689157 6691285 GSVIVG01018962001 18301283 18304437 GSVIVG01016768001 1176542 1187791 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012735001 1098657 1108943 GSVIVG01026089001 24707445 24716860 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01026089001 24707445 24716860 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01032390001 26904968 26908182 GSVIVG01001782001 3051775 3065361 GSVIVG01006002001 24356997 24360326 GSVIVG01000596001 6678843 6691641 GSVIVG01031781001 4315102 4317754 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004185 serine-type carboxypeptidase activity GSVIVG01012475001 13660622 13660717 GSVIVG01031657001 19681838 19700399 GSVIVG01038802001 1387660 1387767 GSVIVG01000127001 15484125 15494123 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01000127001 15484125 15494123 GO:0016043 cellular component organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cellular component. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01000127001 15484125 15494123 GO:0030036 actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01000127001 15484125 15494123 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01000127001 15484125 15494123 GO:0016043 cellular component organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cellular component. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01000127001 15484125 15494123 GO:0030036 actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01001371001 24064477 24067463 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01020977001 16036558 16036890 GSVIVG01008770001 1818068 1820567 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008770001 1818068 1820567 Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity. IEA GO:0004721 phosphoprotein phosphatase activity GSVIVG01000648001 20385194 20393370 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01000648001 20385194 20393370 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01000648001 20385194 20393370 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01000648001 20385194 20393370 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000648001 20385194 20393370 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000648001 20385194 20393370 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000648001 20385194 20393370 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01000648001 20385194 20393370 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01000648001 20385194 20393370 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01000648001 20385194 20393370 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01000648001 20385194 20393370 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01000648001 20385194 20393370 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01021639001 8525942 8526426 GSVIVG01033640001 19024829 19025572 GSVIVG01023184001 21445509 21449885 GSVIVG01026912001 19447292 19450278 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012724001 1013056 1025984 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012724001 1013056 1025984 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01012724001 1013056 1025984 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01008118001 5641390 5648710 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023631001 8236010 8237979 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01025815001 11548182 11560153 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule following transcription initiation. IEA GO:0003711 transcription elongation regulator activity GSVIVG01025815001 11548182 11560153 GO:0006357 regulation of transcription from RNA polymerase II promoter Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. IEA Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule following transcription initiation. IEA GO:0003711 transcription elongation regulator activity GSVIVG01025815001 11548182 11560153 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01025815001 11548182 11560153 GO:0006357 regulation of transcription from RNA polymerase II promoter Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01025815001 11548182 11560153 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025815001 11548182 11560153 GO:0006357 regulation of transcription from RNA polymerase II promoter Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025815001 11548182 11560153 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01025815001 11548182 11560153 GO:0006357 regulation of transcription from RNA polymerase II promoter Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01014691001 8679588 8686228 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nucleotidyl group to a reactant. IEA GO:0016779 nucleotidyltransferase activity GSVIVG01014691001 8679588 8686228 GO:0009435 NAD biosynthetic process The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH. IEA Catalysis of the transfer of a nucleotidyl group to a reactant. IEA GO:0016779 nucleotidyltransferase activity GSVIVG01003283001 14109323 14110551 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003283001 14109323 14110551 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01003283001 14109323 14110551 Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01018995001 17966566 17998572 GSVIVG01008732001 1529488 1530816 GSVIVG01009071001 4705950 4722243 GSVIVG01020914001 17250964 17270067 GO:0030041 actin filament polymerization Assembly of actin filaments by the addition of actin monomers to a filament. IEA GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA GSVIVG01013488001 1580738 1606619 GO:0019064 viral envelope fusion with host membrane A form of viral penetration which involves the fusion of the virion envelope with the cellular membrane. IEA GO:0019031 viral envelope The lipid bilayer and associated glycoproteins that surround many types of virus particle. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01013488001 1580738 1606619 GO:0019064 viral envelope fusion with host membrane A form of viral penetration which involves the fusion of the virion envelope with the cellular membrane. IEA GO:0019031 viral envelope The lipid bilayer and associated glycoproteins that surround many types of virus particle. IEA Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. IEA GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GSVIVG01013488001 1580738 1606619 GO:0019064 viral envelope fusion with host membrane A form of viral penetration which involves the fusion of the virion envelope with the cellular membrane. IEA GO:0019031 viral envelope The lipid bilayer and associated glycoproteins that surround many types of virus particle. IEA Interacting selectively and non-covalently with a receptor on the host cell surface. IEA GO:0046789 host cell surface receptor binding GSVIVG01028717001 19488836 19492409 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01028717001 19488836 19492409 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01028717001 19488836 19492409 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01028717001 19488836 19492409 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01028717001 19488836 19492409 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA A sigma factor is the promoter specificity subunit of eubacterial-type multisubunit RNA polymerases, those whose core subunit composition is often described as alpha(2)-beta-beta-prime. (This type of multisubunit RNA polymerase complex is known to be found in eubacteria and plant plastids). Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, this binds specifically to promoter sequences, with the sigma factor making sequence specific contacts with the promoter elements. The sigma subunit is released from the elongating form of the polymerase and is thus free to act catalytically for multiple RNA polymerase core enzymes. IEA GO:0016987 sigma factor activity GSVIVG01028717001 19488836 19492409 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA A sigma factor is the promoter specificity subunit of eubacterial-type multisubunit RNA polymerases, those whose core subunit composition is often described as alpha(2)-beta-beta-prime. (This type of multisubunit RNA polymerase complex is known to be found in eubacteria and plant plastids). Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, this binds specifically to promoter sequences, with the sigma factor making sequence specific contacts with the promoter elements. The sigma subunit is released from the elongating form of the polymerase and is thus free to act catalytically for multiple RNA polymerase core enzymes. IEA GO:0016987 sigma factor activity GSVIVG01035190001 10148036 10148398 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in). IEA GO:0005432 calcium:sodium antiporter activity GSVIVG01016979001 3130094 3132502 GSVIVG01036338001 3944684 3959725 Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01036338001 3944684 3959725 Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01023720001 9959660 10010205 GSVIVG01023638001 8303024 8313124 GO:0016070 RNA metabolic process The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01023638001 8303024 8313124 GO:0016070 RNA metabolic process The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023491001 11048292 11049764 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01023491001 11048292 11049764 GO:0008299 isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01023491001 11048292 11049764 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA. IEA GO:0004421 hydroxymethylglutaryl-CoA synthase activity GSVIVG01023491001 11048292 11049764 GO:0008299 isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. IEA Catalysis of the reaction: acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA. IEA GO:0004421 hydroxymethylglutaryl-CoA synthase activity GSVIVG01007064001 29971136 29975700 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01001837001 26209022 26210127 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01035713001 3574952 3579692 GO:0015671 oxygen transport The directed movement of oxygen (O2) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01035713001 3574952 3579692 GO:0015671 oxygen transport The directed movement of oxygen (O2) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with oxygen (O2). IEA GO:0019825 oxygen binding GSVIVG01035713001 3574952 3579692 GO:0015671 oxygen transport The directed movement of oxygen (O2) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01018268001 12252400 12255367 GSVIVG01006809001 28720378 28720689 GSVIVG01025747001 12276214 12277848 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01029086001 12253154 12259771 GSVIVG01024939001 5877617 5881733 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01027001001 18657101 18665922 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01027001001 18657101 18665922 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01027001001 18657101 18665922 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01027001001 18657101 18665922 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01027001001 18657101 18665922 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014335001 2734507 2744265 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014335001 2734507 2744265 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014335001 2734507 2744265 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014335001 2734507 2744265 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033391001 21000078 21002628 GO:0000245 spliceosome assembly The aggregation, arrangement and bonding together of the spliceosome, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033391001 21000078 21002628 GO:0000398 nuclear mRNA splicing, via spliceosome The joining together of exons from one or more primary transcripts of nuclear messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028241001 4880423 4884925 GO:0006779 porphyrin biosynthetic process The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group. IEA Catalysis of the reaction: protoporphyrinogen-IX + O2 = protoporphyrin-IX + H2O2. IEA GO:0004729 oxygen-dependent protoporphyrinogen oxidase activity GSVIVG01028241001 4880423 4884925 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: protoporphyrinogen-IX + O2 = protoporphyrin-IX + H2O2. IEA GO:0004729 oxygen-dependent protoporphyrinogen oxidase activity GSVIVG01028241001 4880423 4884925 GO:0006779 porphyrin biosynthetic process The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01028241001 4880423 4884925 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024551001 8918039 8924375 GSVIVG01013523001 2314818 2314985 GSVIVG01012274001 12887817 12920590 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018850001 19266018 19268731 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01015951001 16065309 16074853 GSVIVG01022941001 17777713 17780786 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01022941001 17777713 17780786 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01022941001 17777713 17780786 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022941001 17777713 17780786 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022941001 17777713 17780786 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01022941001 17777713 17780786 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01029826001 162012 164839 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029826001 162012 164839 GO:0009396 folic acid and derivative biosynthetic process The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029826001 162012 164839 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate. IEA GO:0004477 methenyltetrahydrofolate cyclohydrolase activity GSVIVG01029826001 162012 164839 GO:0009396 folic acid and derivative biosynthetic process The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. IEA Catalysis of the reaction: 5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate. IEA GO:0004477 methenyltetrahydrofolate cyclohydrolase activity GSVIVG01029826001 162012 164839 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NADP+ = 5,10-methenyltetrahydrofolate + NADPH + H+. IEA GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity GSVIVG01029826001 162012 164839 GO:0009396 folic acid and derivative biosynthetic process The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. IEA Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NADP+ = 5,10-methenyltetrahydrofolate + NADPH + H+. IEA GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity GSVIVG01029826001 162012 164839 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01029826001 162012 164839 GO:0009396 folic acid and derivative biosynthetic process The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01006642001 27236994 27239452 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01030053001 9272133 9273934 GO:0009765 photosynthesis, light harvesting Absorption and transfer of the energy absorbed from light photons between photosystem reaction centers. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01002871001 36942905 36945653 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01002871001 36942905 36945653 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001199001 852762 859488 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01001199001 852762 859488 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01001199001 852762 859488 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01001199001 852762 859488 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031807001 4586630 4589079 GSVIVG01018388001 9906323 9906996 GSVIVG01026974001 18902731 18903893 GO:0009269 response to desiccation A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a desiccation stimulus, extreme dryness resulting from the prolonged deprivation of water. IEA GSVIVG01019722001 2746469 2750881 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012001001 2286639 2292078 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01028194001 4525870 4528850 GSVIVG01007123001 30188867 30191174 GSVIVG01030061001 9329350 9331956 GSVIVG01023807001 3311927 3325896 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01038568001 21798663 21804471 GSVIVG01026409001 23844524 23862507 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01000482001 14642629 14652553 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01028256001 4974180 4981456 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01028256001 4974180 4981456 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01028256001 4974180 4981456 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028256001 4974180 4981456 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028256001 4974180 4981456 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01028256001 4974180 4981456 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01028256001 4974180 4981456 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01028256001 4974180 4981456 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01028256001 4974180 4981456 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01028256001 4974180 4981456 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01028256001 4974180 4981456 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01028256001 4974180 4981456 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01027694001 14243938 14246299 GSVIVG01027572001 15453533 15455130 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01027851001 8615163 8617937 GSVIVG01027957001 10088505 10130208 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01027957001 10088505 10130208 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01027957001 10088505 10130208 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027957001 10088505 10130208 Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01025524001 14334031 14336489 GSVIVG01007777001 9162806 9164179 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01003730001 7461533 7468498 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01003730001 7461533 7468498 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01003730001 7461533 7468498 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01003730001 7461533 7468498 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01036946001 17095512 17133614 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01035363001 773916 775796 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01035363001 773916 775796 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035363001 773916 775796 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01015766001 17152459 17154221 GSVIVG01022971001 17414353 17415189 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01022971001 17414353 17415189 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01020679001 3172610 3173094 GSVIVG01037190001 28167808 28168860 GSVIVG01012273001 12883160 12884144 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01036663001 19973316 19973552 GSVIVG01022933001 17838867 17845380 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01006742001 27946525 27960886 GSVIVG01031516001 17745838 17756072 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01031516001 17745838 17756072 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031516001 17745838 17756072 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01031516001 17745838 17756072 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01009656001 10237358 10239107 GSVIVG01030031001 9003706 9004468 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01024173001 594823 598576 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01009966001 12893670 12898468 GSVIVG01027210001 18236830 18251417 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01037851001 7125278 7126323 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01032427001 27293960 27303125 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar. IEA GO:0008375 acetylglucosaminyltransferase activity GSVIVG01024176001 584367 587948 GSVIVG01009862001 11898718 11909253 GSVIVG01038529001 11113462 11140644 Catalysis of the transfer of the amide nitrogen of glutamine to a variety of substrates. GATases catalyze two separate reactions at two active sites, which are located either on a single polypeptide chain or on different subunits. In the glutaminase reaction, glutamine is hydrolyzed to glutamate and ammonia, which is added to an acceptor substrate in the synthase reaction. IEA GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor GSVIVG01016777001 1249505 1264169 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01014452001 3894331 3896647 GO:0009296 flagellum assembly The assembly of a flagellum. In bacteria, this is a whiplike motility appendage present on the surface of some species; in eukaryotes, flagella are threadlike protoplasmic extensions used to propel flagellates and sperm. Flagella are composed of flagellin and have the same basic structure as cilia but are longer in proportion to the cell and present in much smaller numbers. IEA GO:0009424 bacterial-type flagellum hook The portion of the flagellum that connects the filament to the basal body. Examples of this component are found in bacteria. IEA Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate. IEA GO:0003774 motor activity GSVIVG01027373001 15568862 15569020 GO:0016568 chromatin modification The alteration of DNA or protein in chromatin, which may result in changing the chromatin structure. IEA Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone. IEA GO:0004402 histone acetyltransferase activity GSVIVG01037451001 13500158 13511953 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01037451001 13500158 13511953 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01018506001 14100069 14218176 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01026177001 13465520 13466423 GSVIVG01006790001 28537062 28537393 GSVIVG01007147001 30474292 30476452 GSVIVG01019659001 2286157 2287242 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01029844001 342116 344455 Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity. IEA GO:0004721 phosphoprotein phosphatase activity GSVIVG01029844001 342116 344455 Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01029844001 342116 344455 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01020454001 19171698 19179184 GSVIVG01037229001 27667979 27672909 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012152001 997178 1000812 GSVIVG01010392001 20100521 20102317 GSVIVG01034208001 14426406 14427041 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01034208001 14426406 14427041 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01034208001 14426406 14427041 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01034208001 14426406 14427041 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01034208001 14426406 14427041 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA IEA GO:0016986 transcription initiation factor activity GSVIVG01034208001 14426406 14427041 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA IEA GO:0016986 transcription initiation factor activity GSVIVG01034208001 14426406 14427041 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA IEA GO:0016986 transcription initiation factor activity GSVIVG01034208001 14426406 14427041 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA IEA GO:0016986 transcription initiation factor activity GSVIVG01030085001 9707559 9714683 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01030085001 9707559 9714683 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01017487001 9247141 9256160 GSVIVG01010011001 13444139 13444288 GSVIVG01013219001 6637768 6638812 GSVIVG01020981001 15961076 15961633 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014887001 11176754 11178908 GSVIVG01036091001 20781049 20782250 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025961001 26569314 26572123 GO:0006094 gluconeogenesis The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. IEA Catalysis of the reaction: D-glucose 6-phosphate = D-fructose 6-phosphate. IEA GO:0004347 glucose-6-phosphate isomerase activity GSVIVG01025961001 26569314 26572123 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the reaction: D-glucose 6-phosphate = D-fructose 6-phosphate. IEA GO:0004347 glucose-6-phosphate isomerase activity GSVIVG01025961001 26569314 26572123 GO:0006094 gluconeogenesis The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025961001 26569314 26572123 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01022591001 5622898 5678479 GSVIVG01002666001 35790526 35790564 GSVIVG01035873001 5107008 5116987 GO:0007154 cell communication Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035873001 5107008 5116987 GO:0007154 cell communication Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. IEA Interacting selectively and non-covalently with any inositol-containing glycerophospholipid. Phosphatidylinositol (PtdIns) and its phosphorylated derivatives are collectively referred to as phosphoinositides (PIs). IEA GO:0035091 phosphoinositide binding GSVIVG01022813001 16903456 16903928 GSVIVG01012146001 1063042 1070438 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01012146001 1063042 1070438 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01012146001 1063042 1070438 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01008940001 3638735 3639936 GSVIVG01022398001 19653799 19665312 GSVIVG01017379001 7551131 7576787 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01017379001 7551131 7576787 GO:0006284 base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01017379001 7551131 7576787 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01017379001 7551131 7576787 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Interacting selectively and non-covalently with damaged DNA. IEA GO:0003684 damaged DNA binding GSVIVG01017379001 7551131 7576787 GO:0006284 base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. IEA Interacting selectively and non-covalently with damaged DNA. IEA GO:0003684 damaged DNA binding GSVIVG01017379001 7551131 7576787 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA Interacting selectively and non-covalently with damaged DNA. IEA GO:0003684 damaged DNA binding GSVIVG01017379001 7551131 7576787 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the cleavage of the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. IEA GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity GSVIVG01017379001 7551131 7576787 GO:0006284 base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. IEA Catalysis of the cleavage of the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. IEA GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity GSVIVG01017379001 7551131 7576787 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA Catalysis of the cleavage of the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. IEA GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity GSVIVG01017379001 7551131 7576787 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01017379001 7551131 7576787 GO:0006284 base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01017379001 7551131 7576787 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01017379001 7551131 7576787 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the removal of oxidized purine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme-substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apurinic (AP) site. IEA GO:0008534 oxidized purine base lesion DNA N-glycosylase activity GSVIVG01017379001 7551131 7576787 GO:0006284 base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. IEA Catalysis of the removal of oxidized purine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme-substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apurinic (AP) site. IEA GO:0008534 oxidized purine base lesion DNA N-glycosylase activity GSVIVG01017379001 7551131 7576787 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA Catalysis of the removal of oxidized purine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme-substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apurinic (AP) site. IEA GO:0008534 oxidized purine base lesion DNA N-glycosylase activity GSVIVG01017379001 7551131 7576787 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the hydrolysis of any N-glycosyl bond. IEA GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds GSVIVG01017379001 7551131 7576787 GO:0006284 base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. IEA Catalysis of the hydrolysis of any N-glycosyl bond. IEA GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds GSVIVG01017379001 7551131 7576787 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA Catalysis of the hydrolysis of any N-glycosyl bond. IEA GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds GSVIVG01015429001 3591246 3603227 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01020262001 22135684 22139255 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01020262001 22135684 22139255 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01002973001 37481941 37483487 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01002973001 37481941 37483487 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01002973001 37481941 37483487 Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01015880001 18906657 18917473 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01015880001 18906657 18917473 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01013792001 7543670 7543982 GSVIVG01007653001 10831351 10834156 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01007653001 10831351 10834156 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01007653001 10831351 10834156 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01007653001 10831351 10834156 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01013704001 2820609 2821349 GSVIVG01037074001 8141263 8145242 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004185 serine-type carboxypeptidase activity GSVIVG01037810001 7673857 7675758 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01012523001 527226 560073 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01012523001 527226 560073 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01012523001 527226 560073 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01028360001 6578091 6585812 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01028360001 6578091 6585812 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028360001 6578091 6585812 Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01028360001 6578091 6585812 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01020424001 19626826 19643204 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020424001 19626826 19643204 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01014457001 3942747 3944969 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01014457001 3942747 3944969 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01014457001 3942747 3944969 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0042651 thylakoid membrane The pigmented membrane of any thylakoid. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01014457001 3942747 3944969 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01014457001 3942747 3944969 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01014457001 3942747 3944969 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0042651 thylakoid membrane The pigmented membrane of any thylakoid. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01014457001 3942747 3944969 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01014457001 3942747 3944969 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01014457001 3942747 3944969 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0042651 thylakoid membrane The pigmented membrane of any thylakoid. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01014457001 3942747 3944969 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+. IEA GO:0008121 ubiquinol-cytochrome-c reductase activity GSVIVG01014457001 3942747 3944969 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+. IEA GO:0008121 ubiquinol-cytochrome-c reductase activity GSVIVG01014457001 3942747 3944969 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0042651 thylakoid membrane The pigmented membrane of any thylakoid. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+. IEA GO:0008121 ubiquinol-cytochrome-c reductase activity GSVIVG01014457001 3942747 3944969 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+. IEA GO:0008121 ubiquinol-cytochrome-c reductase activity GSVIVG01014457001 3942747 3944969 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+. IEA GO:0008121 ubiquinol-cytochrome-c reductase activity GSVIVG01014457001 3942747 3944969 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0042651 thylakoid membrane The pigmented membrane of any thylakoid. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+. IEA GO:0008121 ubiquinol-cytochrome-c reductase activity GSVIVG01014457001 3942747 3944969 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+. IEA GO:0008121 ubiquinol-cytochrome-c reductase activity GSVIVG01014457001 3942747 3944969 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+. IEA GO:0008121 ubiquinol-cytochrome-c reductase activity GSVIVG01014457001 3942747 3944969 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0042651 thylakoid membrane The pigmented membrane of any thylakoid. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+. IEA GO:0008121 ubiquinol-cytochrome-c reductase activity GSVIVG01014457001 3942747 3944969 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: plastoquinol-1 + 2 oxidized plastocyanin = plastoquinone + 2 reduced plastocyanin. IEA GO:0009496 plastoquinol-plastocyanin reductase activity GSVIVG01014457001 3942747 3944969 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: plastoquinol-1 + 2 oxidized plastocyanin = plastoquinone + 2 reduced plastocyanin. IEA GO:0009496 plastoquinol-plastocyanin reductase activity GSVIVG01014457001 3942747 3944969 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0042651 thylakoid membrane The pigmented membrane of any thylakoid. IEA Catalysis of the reaction: plastoquinol-1 + 2 oxidized plastocyanin = plastoquinone + 2 reduced plastocyanin. IEA GO:0009496 plastoquinol-plastocyanin reductase activity GSVIVG01014457001 3942747 3944969 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: plastoquinol-1 + 2 oxidized plastocyanin = plastoquinone + 2 reduced plastocyanin. IEA GO:0009496 plastoquinol-plastocyanin reductase activity GSVIVG01014457001 3942747 3944969 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: plastoquinol-1 + 2 oxidized plastocyanin = plastoquinone + 2 reduced plastocyanin. IEA GO:0009496 plastoquinol-plastocyanin reductase activity GSVIVG01014457001 3942747 3944969 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0042651 thylakoid membrane The pigmented membrane of any thylakoid. IEA Catalysis of the reaction: plastoquinol-1 + 2 oxidized plastocyanin = plastoquinone + 2 reduced plastocyanin. IEA GO:0009496 plastoquinol-plastocyanin reductase activity GSVIVG01014457001 3942747 3944969 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: plastoquinol-1 + 2 oxidized plastocyanin = plastoquinone + 2 reduced plastocyanin. IEA GO:0009496 plastoquinol-plastocyanin reductase activity GSVIVG01014457001 3942747 3944969 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: plastoquinol-1 + 2 oxidized plastocyanin = plastoquinone + 2 reduced plastocyanin. IEA GO:0009496 plastoquinol-plastocyanin reductase activity GSVIVG01014457001 3942747 3944969 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0042651 thylakoid membrane The pigmented membrane of any thylakoid. IEA Catalysis of the reaction: plastoquinol-1 + 2 oxidized plastocyanin = plastoquinone + 2 reduced plastocyanin. IEA GO:0009496 plastoquinol-plastocyanin reductase activity GSVIVG01014457001 3942747 3944969 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01014457001 3942747 3944969 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01014457001 3942747 3944969 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0042651 thylakoid membrane The pigmented membrane of any thylakoid. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01014457001 3942747 3944969 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01014457001 3942747 3944969 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01014457001 3942747 3944969 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0042651 thylakoid membrane The pigmented membrane of any thylakoid. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01014457001 3942747 3944969 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01014457001 3942747 3944969 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01014457001 3942747 3944969 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0042651 thylakoid membrane The pigmented membrane of any thylakoid. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01014457001 3942747 3944969 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction in which a diphenol or related substance acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016679 oxidoreductase activity, acting on diphenols and related substances as donors GSVIVG01014457001 3942747 3944969 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction in which a diphenol or related substance acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016679 oxidoreductase activity, acting on diphenols and related substances as donors GSVIVG01014457001 3942747 3944969 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0042651 thylakoid membrane The pigmented membrane of any thylakoid. IEA Catalysis of an oxidation-reduction (redox) reaction in which a diphenol or related substance acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016679 oxidoreductase activity, acting on diphenols and related substances as donors GSVIVG01014457001 3942747 3944969 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction in which a diphenol or related substance acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016679 oxidoreductase activity, acting on diphenols and related substances as donors GSVIVG01014457001 3942747 3944969 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction in which a diphenol or related substance acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016679 oxidoreductase activity, acting on diphenols and related substances as donors GSVIVG01014457001 3942747 3944969 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0042651 thylakoid membrane The pigmented membrane of any thylakoid. IEA Catalysis of an oxidation-reduction (redox) reaction in which a diphenol or related substance acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016679 oxidoreductase activity, acting on diphenols and related substances as donors GSVIVG01014457001 3942747 3944969 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction in which a diphenol or related substance acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016679 oxidoreductase activity, acting on diphenols and related substances as donors GSVIVG01014457001 3942747 3944969 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction in which a diphenol or related substance acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016679 oxidoreductase activity, acting on diphenols and related substances as donors GSVIVG01014457001 3942747 3944969 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0042651 thylakoid membrane The pigmented membrane of any thylakoid. IEA Catalysis of an oxidation-reduction (redox) reaction in which a diphenol or related substance acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016679 oxidoreductase activity, acting on diphenols and related substances as donors GSVIVG01014457001 3942747 3944969 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01014457001 3942747 3944969 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01014457001 3942747 3944969 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0042651 thylakoid membrane The pigmented membrane of any thylakoid. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01014457001 3942747 3944969 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01014457001 3942747 3944969 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01014457001 3942747 3944969 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0042651 thylakoid membrane The pigmented membrane of any thylakoid. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01014457001 3942747 3944969 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01014457001 3942747 3944969 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01014457001 3942747 3944969 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0042651 thylakoid membrane The pigmented membrane of any thylakoid. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01014457001 3942747 3944969 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01014457001 3942747 3944969 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01014457001 3942747 3944969 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0042651 thylakoid membrane The pigmented membrane of any thylakoid. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01014457001 3942747 3944969 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01014457001 3942747 3944969 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01014457001 3942747 3944969 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0042651 thylakoid membrane The pigmented membrane of any thylakoid. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01014457001 3942747 3944969 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01014457001 3942747 3944969 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01014457001 3942747 3944969 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0042651 thylakoid membrane The pigmented membrane of any thylakoid. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01014457001 3942747 3944969 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051537 2 iron, 2 sulfur cluster binding GSVIVG01014457001 3942747 3944969 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051537 2 iron, 2 sulfur cluster binding GSVIVG01014457001 3942747 3944969 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0042651 thylakoid membrane The pigmented membrane of any thylakoid. IEA Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051537 2 iron, 2 sulfur cluster binding GSVIVG01014457001 3942747 3944969 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051537 2 iron, 2 sulfur cluster binding GSVIVG01014457001 3942747 3944969 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051537 2 iron, 2 sulfur cluster binding GSVIVG01014457001 3942747 3944969 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0042651 thylakoid membrane The pigmented membrane of any thylakoid. IEA Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051537 2 iron, 2 sulfur cluster binding GSVIVG01014457001 3942747 3944969 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051537 2 iron, 2 sulfur cluster binding GSVIVG01014457001 3942747 3944969 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051537 2 iron, 2 sulfur cluster binding GSVIVG01014457001 3942747 3944969 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0042651 thylakoid membrane The pigmented membrane of any thylakoid. IEA Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051537 2 iron, 2 sulfur cluster binding GSVIVG01024193001 457048 458789 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01024193001 457048 458789 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01024193001 457048 458789 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01024193001 457048 458789 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01024781001 7005672 7007231 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01024781001 7005672 7007231 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01024781001 7005672 7007231 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01024781001 7005672 7007231 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01013615001 1614722 1619739 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013615001 1614722 1619739 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01013615001 1614722 1619739 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01013615001 1614722 1619739 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01027855001 8681356 8685240 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01027855001 8681356 8685240 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GSVIVG01027855001 8681356 8685240 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01033404001 20939535 20943791 GSVIVG01021417001 5088557 5090999 GSVIVG01023934001 2372022 2379593 GSVIVG01000657001 20477219 20494562 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000657001 20477219 20494562 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000657001 20477219 20494562 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000657001 20477219 20494562 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014236001 1804594 1806793 GSVIVG01035732001 3778153 3790808 GSVIVG01028933001 17263940 17278204 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01028933001 17263940 17278204 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01022576001 5325803 5327236 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01022576001 5325803 5327236 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013762001 7839046 7856993 GSVIVG01024247001 175244 175993 GSVIVG01004585001 39133967 39137315 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01022197001 17383505 17389637 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01022197001 17383505 17389637 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01022197001 17383505 17389637 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01022197001 17383505 17389637 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01022197001 17383505 17389637 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01022197001 17383505 17389637 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01014599001 5477937 5482499 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01014599001 5477937 5482499 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01014599001 5477937 5482499 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014599001 5477937 5482499 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014599001 5477937 5482499 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014599001 5477937 5482499 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014599001 5477937 5482499 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01014599001 5477937 5482499 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01011991001 2369606 2370258 GSVIVG01013163001 7360572 7365558 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01013163001 7360572 7365558 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01013163001 7360572 7365558 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01013163001 7360572 7365558 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01013163001 7360572 7365558 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01013163001 7360572 7365558 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01013163001 7360572 7365558 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01013163001 7360572 7365558 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016819001 1651220 1654645 GSVIVG01036438001 21915049 21915827 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01036438001 21915049 21915827 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01023006001 17003284 17009885 GSVIVG01017421001 8298662 8307420 GSVIVG01000452001 8142143 8142424 GSVIVG01028094001 3750368 3757393 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01028094001 3750368 3757393 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01020121001 10146181 10150591 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01010719001 12747651 12749219 GSVIVG01030539001 6578837 6585356 Interacting selectively and non-covalently with a lipid. IEA GO:0008289 lipid binding GSVIVG01018495001 14302148 14302916 GSVIVG01021499001 6192248 6193694 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021499001 6192248 6193694 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01021499001 6192248 6193694 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01018266001 12267476 12285581 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01026899001 19572127 19576382 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01026899001 19572127 19576382 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01026899001 19572127 19576382 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01026899001 19572127 19576382 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009934001 12533121 12534693 GSVIVG01009307001 7189863 7220111 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01009307001 7189863 7220111 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01013266001 6021601 6023561 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013266001 6021601 6023561 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01030046001 9116731 9122807 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01030046001 9116731 9122807 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01017227001 5664443 5665683 GSVIVG01001899001 6929325 6954013 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin. IEA GO:0004221 ubiquitin thiolesterase activity GSVIVG01031287001 608260 611627 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005801 cis-Golgi network The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum. IEA GSVIVG01031287001 608260 611627 GO:0006888 ER to Golgi vesicle-mediated transport The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi. IEA GO:0005801 cis-Golgi network The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum. IEA GSVIVG01029321001 16917096 16919662 GSVIVG01012448001 950626 959518 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GSVIVG01012448001 950626 959518 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GSVIVG01009477001 8708556 8710114 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01009477001 8708556 8710114 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01026595001 21239773 21242831 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01003129001 7509309 7513858 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003129001 7509309 7513858 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003129001 7509309 7513858 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003129001 7509309 7513858 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003129001 7509309 7513858 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003129001 7509309 7513858 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01003129001 7509309 7513858 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01003129001 7509309 7513858 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01003129001 7509309 7513858 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01003129001 7509309 7513858 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01003129001 7509309 7513858 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01003129001 7509309 7513858 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01003129001 7509309 7513858 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01003129001 7509309 7513858 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01003129001 7509309 7513858 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01003129001 7509309 7513858 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003129001 7509309 7513858 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003129001 7509309 7513858 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003129001 7509309 7513858 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003129001 7509309 7513858 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003129001 7509309 7513858 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of calcium (Ca) ions from one side of a membrane to the other. IEA GO:0015085 calcium ion transmembrane transporter activity GSVIVG01003129001 7509309 7513858 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of calcium (Ca) ions from one side of a membrane to the other. IEA GO:0015085 calcium ion transmembrane transporter activity GSVIVG01003129001 7509309 7513858 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of calcium (Ca) ions from one side of a membrane to the other. IEA GO:0015085 calcium ion transmembrane transporter activity GSVIVG01003129001 7509309 7513858 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of calcium (Ca) ions from one side of a membrane to the other. IEA GO:0015085 calcium ion transmembrane transporter activity GSVIVG01003129001 7509309 7513858 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of calcium (Ca) ions from one side of a membrane to the other. IEA GO:0015085 calcium ion transmembrane transporter activity GSVIVG01003129001 7509309 7513858 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01003129001 7509309 7513858 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01003129001 7509309 7513858 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01003129001 7509309 7513858 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01003129001 7509309 7513858 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01003129001 7509309 7513858 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01003129001 7509309 7513858 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01003129001 7509309 7513858 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01003129001 7509309 7513858 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01003129001 7509309 7513858 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01028693001 19786593 19787144 GSVIVG01037119001 28939533 28940614 GSVIVG01016412001 4153360 4156461 GSVIVG01008846001 2761095 2772564 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01008846001 2761095 2772564 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01008846001 2761095 2772564 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01008846001 2761095 2772564 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01014914001 11722131 11723599 GO:0009987 cellular process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. IEA GSVIVG01015454001 3811540 3816537 GSVIVG01004502001 38861093 38861959 GSVIVG01024566001 8804399 8809509 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01024566001 8804399 8809509 GO:0006419 alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01024566001 8804399 8809509 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala). IEA GO:0004813 alanine-tRNA ligase activity GSVIVG01024566001 8804399 8809509 GO:0006419 alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala). IEA GO:0004813 alanine-tRNA ligase activity GSVIVG01024566001 8804399 8809509 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024566001 8804399 8809509 GO:0006419 alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033882001 17044753 17046970 GSVIVG01006894001 28931224 28934832 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01038578001 21746015 21749300 GSVIVG01005579001 40696118 40697483 GSVIVG01013677001 2465510 2468182 GSVIVG01010856001 16800509 16867999 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010856001 16800509 16867999 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01010856001 16800509 16867999 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01033715001 18393888 18394471 GSVIVG01015535001 4630268 4635183 GO:0006788 heme oxidation The chemical reactions and pathways resulting in the loss of electrons from one or more atoms in heme. IEA Catalysis of the reaction: heme + 3 donor-H2 + 3 O2 = biliverdin + Fe2+ + CO + 3 acceptor + 3 H2O. IEA GO:0004392 heme oxygenase (decyclizing) activity GSVIVG01015535001 4630268 4635183 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: heme + 3 donor-H2 + 3 O2 = biliverdin + Fe2+ + CO + 3 acceptor + 3 H2O. IEA GO:0004392 heme oxygenase (decyclizing) activity GSVIVG01000828001 2645438 2649347 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01000828001 2645438 2649347 Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium. IEA GO:0005544 calcium-dependent phospholipid binding GSVIVG01015644001 14784225 14797327 GSVIVG01021822001 6920455 6929047 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01007565001 11958350 11967045 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids. IEA GO:0004518 nuclease activity GSVIVG01005874001 22418505 22436337 GSVIVG01012670001 496819 502885 GSVIVG01034678001 7529742 7538842 GSVIVG01033517001 20068603 20072280 GSVIVG01026338001 14265392 14267197 GSVIVG01009501001 8883484 8885782 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01022290001 18275255 18275629 GSVIVG01004595001 39153866 39155898 GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA GSVIVG01029394001 16178829 16197202 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01029394001 16178829 16197202 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01029394001 16178829 16197202 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01024961001 5660990 5664273 GO:0006626 protein targeting to mitochondrion The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein. IEA GO:0042719 mitochondrial intermembrane space protein transporter complex Soluble complex of the mitochondrial intermembrane space composed of various combinations of small Tim proteins; acts as a protein transporter to guide proteins to the Tim22 complex for insertion into the mitochondrial inner membrane. IEA GSVIVG01024961001 5660990 5664273 GO:0045039 protein import into mitochondrial inner membrane The import of proteins into the mitochondria inner membrane. Inner membrane proteins are first imported into the matrix space where the matrix-targeting sequence is removed; how these proteins then are incorporated into the inner membrane is not known. IEA GO:0042719 mitochondrial intermembrane space protein transporter complex Soluble complex of the mitochondrial intermembrane space composed of various combinations of small Tim proteins; acts as a protein transporter to guide proteins to the Tim22 complex for insertion into the mitochondrial inner membrane. IEA GSVIVG01031615001 18984607 19001277 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01031280001 631496 634713 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01015929001 15261892 15262137 GSVIVG01022278001 18114524 18121281 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005971 ribonucleoside-diphosphate reductase complex An enzyme complex composed of 2-4 or more subunits, which usually contains nonheme iron and requires ATP for catalysis. Catalyzes the formation of 2'-deoxyribonucleoside diphosphate and thioredoxin disulfide from ribonucleoside diphosphate and thioredoxin. IEA Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin. IEA GO:0004748 ribonucleoside-diphosphate reductase activity GSVIVG01022278001 18114524 18121281 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005971 ribonucleoside-diphosphate reductase complex An enzyme complex composed of 2-4 or more subunits, which usually contains nonheme iron and requires ATP for catalysis. Catalyzes the formation of 2'-deoxyribonucleoside diphosphate and thioredoxin disulfide from ribonucleoside diphosphate and thioredoxin. IEA Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin. IEA GO:0004748 ribonucleoside-diphosphate reductase activity GSVIVG01022278001 18114524 18121281 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005971 ribonucleoside-diphosphate reductase complex An enzyme complex composed of 2-4 or more subunits, which usually contains nonheme iron and requires ATP for catalysis. Catalyzes the formation of 2'-deoxyribonucleoside diphosphate and thioredoxin disulfide from ribonucleoside diphosphate and thioredoxin. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01022278001 18114524 18121281 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005971 ribonucleoside-diphosphate reductase complex An enzyme complex composed of 2-4 or more subunits, which usually contains nonheme iron and requires ATP for catalysis. Catalyzes the formation of 2'-deoxyribonucleoside diphosphate and thioredoxin disulfide from ribonucleoside diphosphate and thioredoxin. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01022278001 18114524 18121281 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005971 ribonucleoside-diphosphate reductase complex An enzyme complex composed of 2-4 or more subunits, which usually contains nonheme iron and requires ATP for catalysis. Catalyzes the formation of 2'-deoxyribonucleoside diphosphate and thioredoxin disulfide from ribonucleoside diphosphate and thioredoxin. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022278001 18114524 18121281 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005971 ribonucleoside-diphosphate reductase complex An enzyme complex composed of 2-4 or more subunits, which usually contains nonheme iron and requires ATP for catalysis. Catalyzes the formation of 2'-deoxyribonucleoside diphosphate and thioredoxin disulfide from ribonucleoside diphosphate and thioredoxin. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022483001 3640817 3646762 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01034893001 16137227 16137823 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034893001 16137227 16137823 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01005665001 20997673 20998472 GSVIVG01037883001 6775424 6776620 GSVIVG01033192001 9388596 9395789 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01035766001 4133781 4133891 GSVIVG01027667001 14506625 14510690 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027667001 14506625 14510690 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reversible transfer of a 2-carbon ketol group (CH2OH-CO-) from a ketose phosphate donor to an aldose phosphate acceptor. IEA GO:0004802 transketolase activity GSVIVG01032128001 22384156 22415709 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032128001 22384156 22415709 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032128001 22384156 22415709 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032128001 22384156 22415709 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA Catalysis of the reaction: tRNA-uracil + acceptor = tRNA-dihydrouridine + reduced acceptor. IEA GO:0017150 tRNA dihydrouridine synthase activity GSVIVG01032128001 22384156 22415709 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: tRNA-uracil + acceptor = tRNA-dihydrouridine + reduced acceptor. IEA GO:0017150 tRNA dihydrouridine synthase activity GSVIVG01032128001 22384156 22415709 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: tRNA-uracil + acceptor = tRNA-dihydrouridine + reduced acceptor. IEA GO:0017150 tRNA dihydrouridine synthase activity GSVIVG01032128001 22384156 22415709 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01032128001 22384156 22415709 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01032128001 22384156 22415709 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01009188001 5914014 5917916 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with vasopressin to initiate a change in cell activity. IEA GO:0005000 vasopressin receptor activity GSVIVG01024855001 6462050 6463448 GSVIVG01012247001 230334 235218 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01017907001 4535668 4538945 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01017907001 4535668 4538945 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01017907001 4535668 4538945 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017907001 4535668 4538945 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017907001 4535668 4538945 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01017907001 4535668 4538945 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01038206001 24336681 24348881 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01028765001 19092048 19094299 GSVIVG01008821001 2460774 2467215 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0008236 serine-type peptidase activity GSVIVG01008821001 2460774 2467215 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0008236 serine-type peptidase activity GSVIVG01026376001 15268980 15280281 GSVIVG01010361001 19802033 19816465 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01010361001 19802033 19816465 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01010361001 19802033 19816465 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Catalysis of the reaction: ATP + AMP = 2 ADP. IEA GO:0004017 adenylate kinase activity GSVIVG01010361001 19802033 19816465 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Catalysis of the reaction: ATP + AMP = 2 ADP. IEA GO:0004017 adenylate kinase activity GSVIVG01010361001 19802033 19816465 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010361001 19802033 19816465 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010361001 19802033 19816465 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a phosphate group (acceptor). IEA GO:0016776 phosphotransferase activity, phosphate group as acceptor GSVIVG01010361001 19802033 19816465 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a phosphate group (acceptor). IEA GO:0016776 phosphotransferase activity, phosphate group as acceptor GSVIVG01010361001 19802033 19816465 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Catalysis of the reaction: ATP + nucleoside monophosphate = ADP + nucleoside diphosphate. IEA GO:0019201 nucleotide kinase activity GSVIVG01010361001 19802033 19816465 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Catalysis of the reaction: ATP + nucleoside monophosphate = ADP + nucleoside diphosphate. IEA GO:0019201 nucleotide kinase activity GSVIVG01010361001 19802033 19816465 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate. IEA GO:0019205 nucleobase, nucleoside, nucleotide kinase activity GSVIVG01010361001 19802033 19816465 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate. IEA GO:0019205 nucleobase, nucleoside, nucleotide kinase activity GSVIVG01035461001 1439746 1447540 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01017501001 9530661 9537136 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01017501001 9530661 9537136 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01017501001 9530661 9537136 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017501001 9530661 9537136 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017501001 9530661 9537136 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01017501001 9530661 9537136 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01017501001 9530661 9537136 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01017501001 9530661 9537136 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01029396001 16227031 16230509 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01029396001 16227031 16230509 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01029396001 16227031 16230509 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01029396001 16227031 16230509 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01029396001 16227031 16230509 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01029396001 16227031 16230509 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01029396001 16227031 16230509 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01029396001 16227031 16230509 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01006456001 26113016 26113347 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01006456001 26113016 26113347 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01004891001 16457844 16459777 GSVIVG01022366001 19079908 19094430 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01022366001 19079908 19094430 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01022366001 19079908 19094430 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01022366001 19079908 19094430 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036888001 18148043 18167990 GSVIVG01035398001 1004337 1006409 GSVIVG01008852001 2822057 2827234 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008237 metallopeptidase activity GSVIVG01008852001 2822057 2827234 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008237 metallopeptidase activity GSVIVG01008852001 2822057 2827234 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01008852001 2822057 2827234 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01008852001 2822057 2827234 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01008852001 2822057 2827234 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01023367001 19243401 19255626 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01005203001 19165017 19168667 GO:0009103 lipopolysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate. IEA GO:0008690 3-deoxy-manno-octulosonate cytidylyltransferase activity GSVIVG01005203001 19165017 19168667 GO:0019294 keto-3-deoxy-D-manno-octulosonic acid biosynthetic process The chemical reactions and pathways resulting in the formation of keto-3-deoxy-D-manno-octulosonic acid, an acidic sugar present in lipopolysaccharides of the outer membranes of some Gram-negative bacteria. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate. IEA GO:0008690 3-deoxy-manno-octulosonate cytidylyltransferase activity GSVIVG01007904001 7713434 7715371 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025225001 3060641 3064388 GSVIVG01013173001 7149352 7159858 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01013173001 7149352 7159858 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01013173001 7149352 7159858 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01013173001 7149352 7159858 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01013173001 7149352 7159858 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001251001 4711931 4719433 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01001251001 4711931 4719433 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006294001 24611602 24611859 GSVIVG01028471001 8070762 8072533 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01028471001 8070762 8072533 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01028471001 8070762 8072533 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01028471001 8070762 8072533 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01012459001 1166884 1168222 GSVIVG01030766001 15623296 15623490 GSVIVG01006347001 25095978 25102339 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01035140001 1797070 1798034 GSVIVG01012831001 5911003 5913079 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01034578001 19152607 19156541 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01029852001 410291 415882 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01005091001 14427784 14431822 GSVIVG01003371001 9475118 9477045 GSVIVG01032719001 1280451 1282648 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01011098001 1609890 1611372 GSVIVG01033261001 22063148 22076083 GO:0007010 cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01026299001 13006928 13017295 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01001373001 24074026 24081260 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01014763001 9387450 9392138 GSVIVG01011808001 3981902 3993615 GO:0006659 phosphatidylserine biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine. IEA GSVIVG01017795001 3539744 3541957 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01017795001 3539744 3541957 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01016733001 738872 741026 GSVIVG01018321001 11123361 11137148 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01018321001 11123361 11137148 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01018321001 11123361 11137148 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01018321001 11123361 11137148 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01029011001 10653001 10654241 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. IEA GO:0004364 glutathione transferase activity GSVIVG01025059001 4873544 4881334 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01023608001 7931552 7957611 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01023608001 7931552 7957611 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01023608001 7931552 7957611 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01023608001 7931552 7957611 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01023608001 7931552 7957611 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01023608001 7931552 7957611 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01019894001 4296413 4298771 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019894001 4296413 4298771 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019894001 4296413 4298771 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01019894001 4296413 4298771 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. IEA GO:0048037 cofactor binding GSVIVG01019894001 4296413 4298771 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01010373001 19921837 19923437 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01010373001 19921837 19923437 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010373001 19921837 19923437 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01036635001 19521293 19522773 GSVIVG01007988001 6886160 6887564 GO:0009765 photosynthesis, light harvesting Absorption and transfer of the energy absorbed from light photons between photosystem reaction centers. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA GSVIVG01007988001 6886160 6887564 GO:0009765 photosynthesis, light harvesting Absorption and transfer of the energy absorbed from light photons between photosystem reaction centers. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01035173001 12769375 12789437 GSVIVG01029116001 19455412 19458442 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01029116001 19455412 19458442 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01029116001 19455412 19458442 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01029116001 19455412 19458442 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01029116001 19455412 19458442 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01029116001 19455412 19458442 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01029116001 19455412 19458442 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029116001 19455412 19458442 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029116001 19455412 19458442 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01029116001 19455412 19458442 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01005456001 40338851 40340553 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01005456001 40338851 40340553 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01005456001 40338851 40340553 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01005456001 40338851 40340553 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01005456001 40338851 40340553 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032706001 1360880 1362840 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01032706001 1360880 1362840 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01032706001 1360880 1362840 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01032706001 1360880 1362840 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01032706001 1360880 1362840 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01032706001 1360880 1362840 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01017716001 2867206 2868567 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01021638001 8514407 8520194 GSVIVG01024172001 607518 613848 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01024172001 607518 613848 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate. IEA GO:0003774 motor activity GSVIVG01024172001 607518 613848 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01024172001 607518 613848 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01004332001 38130645 38135568 GSVIVG01011628001 5765351 5767833 GSVIVG01036712001 23462617 23464298 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01032839001 341585 342881 GSVIVG01011724001 4765517 4767180 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GSVIVG01011724001 4765517 4767180 GO:0009607 response to biotic stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism. IEA GSVIVG01008428001 2193457 2193654 GSVIVG01033456001 20551190 20556017 GSVIVG01024774001 7063507 7065748 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01013196001 6868973 6869682 GO:0009790 embryo development The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant. IEA GSVIVG01000848001 2884115 2898583 Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum. IEA GO:0003993 acid phosphatase activity GSVIVG01000848001 2884115 2898583 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01000848001 2884115 2898583 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01021884001 6026347 6048725 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01021884001 6026347 6048725 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01021884001 6026347 6048725 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01021884001 6026347 6048725 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020827001 1479996 1485616 GSVIVG01003861001 12966966 12984054 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01003861001 12966966 12984054 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01036721001 23319003 23339683 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01036721001 23319003 23339683 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01038469001 9826460 9827998 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01038469001 9826460 9827998 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01038469001 9826460 9827998 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01038469001 9826460 9827998 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01038469001 9826460 9827998 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01002913001 37226447 37227355 GSVIVG01019744001 2898046 2908205 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01030562001 6762058 6764987 GSVIVG01020658001 3365915 3367561 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01020658001 3365915 3367561 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01020658001 3365915 3367561 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01020658001 3365915 3367561 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01020658001 3365915 3367561 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01020658001 3365915 3367561 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01020658001 3365915 3367561 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01020658001 3365915 3367561 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01003995001 14146234 14147644 GSVIVG01019832001 3727275 3728813 GSVIVG01029850001 396579 401857 GSVIVG01028227001 4773584 4776241 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000977001 11036550 11043795 GSVIVG01033286001 21822247 21824214 GO:0006694 steroid biosynthetic process The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01033286001 21822247 21824214 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01030903001 18769893 18770273 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01003970001 26398046 26398916 GSVIVG01035321001 450931 456000 GSVIVG01019469001 886847 894005 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01019469001 886847 894005 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01019469001 886847 894005 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01019469001 886847 894005 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019469001 886847 894005 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019469001 886847 894005 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019469001 886847 894005 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01019469001 886847 894005 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01019469001 886847 894005 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01019469001 886847 894005 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01019469001 886847 894005 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01019469001 886847 894005 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01019469001 886847 894005 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01019469001 886847 894005 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01019469001 886847 894005 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01019469001 886847 894005 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01019469001 886847 894005 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01019469001 886847 894005 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01037438001 13743650 13745997 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01037438001 13743650 13745997 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01021212001 2577241 2577870 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01021212001 2577241 2577870 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the synthesis of a short RNA primer on a DNA template, providing a free 3'-OH that can be extended by DNA-directed DNA polymerases. Catalyzed by a DNA-directed RNA polymerase that forms a complex with alpha DNA polymerase. IEA GO:0003896 DNA primase activity GSVIVG01021212001 2577241 2577870 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01021212001 2577241 2577870 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01032516001 28024251 28024997 GSVIVG01015055001 753904 759768 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA GSVIVG01015055001 753904 759768 GO:0044249 cellular biosynthetic process The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. IEA GSVIVG01036173001 19825041 19832803 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01036173001 19825041 19832803 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027421001 16877122 16882572 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01027421001 16877122 16882572 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01027421001 16877122 16882572 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01027421001 16877122 16882572 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01027421001 16877122 16882572 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01027421001 16877122 16882572 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01027421001 16877122 16882572 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027421001 16877122 16882572 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027421001 16877122 16882572 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01027421001 16877122 16882572 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01023805001 3353229 3358041 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA Catalysis of the reaction: ATP + alpha-D-glucose 1-phosphate = diphosphate + ADP-glucose. IEA GO:0008878 glucose-1-phosphate adenylyltransferase activity GSVIVG01023805001 3353229 3358041 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: ATP + alpha-D-glucose 1-phosphate = diphosphate + ADP-glucose. IEA GO:0008878 glucose-1-phosphate adenylyltransferase activity GSVIVG01023805001 3353229 3358041 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01023805001 3353229 3358041 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01023805001 3353229 3358041 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA Catalysis of the transfer of a nucleotidyl group to a reactant. IEA GO:0016779 nucleotidyltransferase activity GSVIVG01023805001 3353229 3358041 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nucleotidyl group to a reactant. IEA GO:0016779 nucleotidyltransferase activity GSVIVG01005717001 21555421 21559976 GSVIVG01008151001 5295200 5310273 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01008151001 5295200 5310273 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01008151001 5295200 5310273 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008151001 5295200 5310273 Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01027179001 17223857 17226144 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01027179001 17223857 17226144 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01027179001 17223857 17226144 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01027179001 17223857 17226144 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01027179001 17223857 17226144 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01027179001 17223857 17226144 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01027179001 17223857 17226144 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01027179001 17223857 17226144 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01018455001 14839808 14840800 GSVIVG01037835001 7342140 7357074 GO:0000103 sulfate assimilation The pathways by which inorganic sulfate is processed and incorporated into sulfated compounds. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037835001 7342140 7357074 GO:0000103 sulfate assimilation The pathways by which inorganic sulfate is processed and incorporated into sulfated compounds. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01037835001 7342140 7357074 GO:0000103 sulfate assimilation The pathways by which inorganic sulfate is processed and incorporated into sulfated compounds. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01005551001 40617615 40618067 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin. IEA GO:0004221 ubiquitin thiolesterase activity GSVIVG01020603001 3887616 3892967 Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. IEA GO:0008171 O-methyltransferase activity GSVIVG01012667001 462316 466886 GSVIVG01002274001 33832168 33835552 GO:0009416 response to light stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01002274001 33832168 33835552 GO:0009416 response to light stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01034099001 15153012 15157096 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01026940001 19216956 19218563 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01026940001 19216956 19218563 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01026940001 19216956 19218563 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01026940001 19216956 19218563 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01007652001 10834158 10834817 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01007652001 10834158 10834817 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01007652001 10834158 10834817 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01007652001 10834158 10834817 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01030125001 10069804 10071244 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030125001 10069804 10071244 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01022035001 4034741 4038791 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01022035001 4034741 4038791 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01022035001 4034741 4038791 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01022035001 4034741 4038791 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01030953001 19613189 19614219 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01030953001 19613189 19614219 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01030953001 19613189 19614219 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01030953001 19613189 19614219 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01001484001 5007824 5009555 GSVIVG01027492001 16252689 16269416 GO:0001503 ossification The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance. IEA GSVIVG01027492001 16252689 16269416 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GSVIVG01005284001 490485 509186 GSVIVG01008090001 5860757 5862334 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01038759001 608653 609138 GSVIVG01013049001 9179293 9192139 GO:0006914 autophagy The process by which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA GSVIVG01018682001 11177416 11179974 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029784001 14627943 14636401 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01029784001 14627943 14636401 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01029784001 14627943 14636401 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01029784001 14627943 14636401 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01017634001 2171260 2173222 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01003467001 10539130 10543945 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01003467001 10539130 10543945 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01003467001 10539130 10543945 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003467001 10539130 10543945 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003467001 10539130 10543945 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01003467001 10539130 10543945 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01012833001 5917617 5931419 GSVIVG01021868001 6246150 6260990 GO:0006535 cysteine biosynthetic process from serine The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021868001 6246150 6260990 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021868001 6246150 6260990 GO:0006535 cysteine biosynthetic process from serine The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine. IEA Catalysis of the reaction: O3-acetyl-L-serine + H2S = L-cysteine + acetate. IEA GO:0004124 cysteine synthase activity GSVIVG01021868001 6246150 6260990 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: O3-acetyl-L-serine + H2S = L-cysteine + acetate. IEA GO:0004124 cysteine synthase activity GSVIVG01021868001 6246150 6260990 GO:0006535 cysteine biosynthetic process from serine The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01021868001 6246150 6260990 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01028367001 6686911 6707310 GO:0032313 regulation of Rab GTPase activity Any process that modulates the activity of a GTPase of the Rab family. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Increases the rate of GTP hydrolysis by a GTPase of the Rab family. IEA GO:0005097 Rab GTPase activator activity GSVIVG01024698001 7643002 7643805 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01024698001 7643002 7643805 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01011699001 5011824 5018047 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the reaction: pectin + n H2O = n methanol + pectate. IEA GO:0030599 pectinesterase activity GSVIVG01003362001 9369975 9370343 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA GSVIVG01003362001 9369975 9370343 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA GSVIVG01033669001 18791535 18796619 GSVIVG01013433001 509645 513093 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01013433001 509645 513093 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01013433001 509645 513093 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01013433001 509645 513093 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01013433001 509645 513093 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01013433001 509645 513093 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01013433001 509645 513093 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01013433001 509645 513093 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01013433001 509645 513093 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01000724001 193329 199382 GSVIVG01037959001 11627282 11642515 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01018305001 11401995 11402840 GSVIVG01028870001 17944977 17949854 GSVIVG01033356001 21244264 21247057 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01029937001 1761043 1769183 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033977001 16147769 16154624 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01033977001 16147769 16154624 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01033977001 16147769 16154624 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01033977001 16147769 16154624 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033977001 16147769 16154624 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030248001 9904673 9906733 GSVIVG01011815001 3887165 3889989 GSVIVG01005229001 19536952 19537932 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01031779001 4299948 4306720 GSVIVG01019269001 2292296 2293572 GSVIVG01022437001 3034519 3035221 GSVIVG01019860001 3923541 3929358 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019860001 3923541 3929358 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01007604001 11352417 11359966 GSVIVG01014391001 3331337 3333335 GSVIVG01011952001 2692100 2698939 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01011952001 2692100 2698939 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01011952001 2692100 2698939 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004185 serine-type carboxypeptidase activity GSVIVG01011952001 2692100 2698939 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004185 serine-type carboxypeptidase activity GSVIVG01011952001 2692100 2698939 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01011952001 2692100 2698939 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01011952001 2692100 2698939 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01011952001 2692100 2698939 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01011952001 2692100 2698939 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011952001 2692100 2698939 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031014001 20978049 20988219 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01021111001 1507666 1557047 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: 1,4-alpha-D-glucosyl(n) + phosphate = 1,4-alpha-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate. The name should be qualified in each instance by adding the name of the natural substrate, e.g. maltodextrin phosphorylase, starch phosphorylase, glycogen phosphorylase. IEA GO:0004645 phosphorylase activity GSVIVG01021111001 1507666 1557047 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01018696001 10998689 11005427 GSVIVG01037863001 6998808 6999663 GSVIVG01013242001 6355689 6376881 GSVIVG01011738001 4685930 4687708 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01011738001 4685930 4687708 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01011738001 4685930 4687708 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01011738001 4685930 4687708 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01011738001 4685930 4687708 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01011738001 4685930 4687708 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01001734001 641312 644211 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01024134001 867890 868156 GSVIVG01029757001 14248653 14249752 GSVIVG01020866001 798469 823317 GSVIVG01037837001 7322988 7324195 GSVIVG01033951001 16385082 16391942 GSVIVG01004979001 17213063 17222030 GSVIVG01032980001 24790728 24792370 GSVIVG01031610001 18907193 18915663 GSVIVG01030347001 8380825 8381136 GSVIVG01003554001 14600782 14606877 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01003554001 14600782 14606877 GO:0006970 response to osmotic stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01003554001 14600782 14606877 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01003554001 14600782 14606877 GO:0006970 response to osmotic stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01003554001 14600782 14606877 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01003554001 14600782 14606877 GO:0006970 response to osmotic stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01003554001 14600782 14606877 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003554001 14600782 14606877 GO:0006970 response to osmotic stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000219001 16208203 16209037 GSVIVG01031282001 624152 626233 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01030064001 9405822 9406860 GSVIVG01028647001 11547103 11555478 GSVIVG01028156001 4278001 4282772 GSVIVG01036761001 22897111 22905063 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01036761001 22897111 22905063 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01036761001 22897111 22905063 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01036761001 22897111 22905063 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036761001 22897111 22905063 Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01036761001 22897111 22905063 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01031137001 1830278 1835941 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01031137001 1830278 1835941 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031137001 1830278 1835941 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01031137001 1830278 1835941 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01031137001 1830278 1835941 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01026106001 24517302 24517710 GSVIVG01030340001 8540623 8570256 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029539001 21846622 21854752 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01027657001 14564997 14583676 GO:0009306 protein secretion The controlled release of proteins from a cell or group of cells. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01020306001 21634750 21638325 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020306001 21634750 21638325 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009615001 9901320 9904980 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01009615001 9901320 9904980 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01009615001 9901320 9904980 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01009615001 9901320 9904980 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001662001 14041068 14042290 GSVIVG01030973001 20089741 20099710 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01038688001 20998715 21001887 GSVIVG01021413001 5074553 5076856 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01021394001 4867693 4868628 GSVIVG01038446001 12490597 12492761 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038446001 12490597 12492761 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035000001 803251 807772 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). IEA GO:0003755 peptidyl-prolyl cis-trans isomerase activity GSVIVG01024793001 6901466 6907000 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01028464001 7990589 7996479 GSVIVG01010778001 22497566 22500287 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01010778001 22497566 22500287 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01023504001 10843486 10846651 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01010486001 20997839 21002039 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01010486001 20997839 21002039 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01034231001 13115765 13117457 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01034231001 13115765 13117457 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01034231001 13115765 13117457 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01034231001 13115765 13117457 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01034231001 13115765 13117457 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01034231001 13115765 13117457 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01034231001 13115765 13117457 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034231001 13115765 13117457 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014987001 11619 12694 GSVIVG01016426001 4036186 4049281 GSVIVG01029837001 314155 314398 GSVIVG01027714001 13947695 13956656 GSVIVG01011794001 4095417 4103225 GSVIVG01000777001 22151 24184 GSVIVG01035108001 1527457 1537313 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Stops, prevents or reduces the activity of an enzyme. IEA GO:0004857 enzyme inhibitor activity GSVIVG01035108001 1527457 1537313 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the reaction: pectin + n H2O = n methanol + pectate. IEA GO:0030599 pectinesterase activity GSVIVG01023030001 16624200 16625307 GSVIVG01000996001 11241300 11242543 GSVIVG01024651001 8022314 8025083 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01021020001 15201477 15223939 GSVIVG01016276001 5602025 5605019 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01016276001 5602025 5605019 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01016276001 5602025 5605019 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01016276001 5602025 5605019 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01036009001 7134442 7137026 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01036009001 7134442 7137026 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01036009001 7134442 7137026 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01036009001 7134442 7137026 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01020912001 17290606 17357547 GSVIVG01008361001 2877374 2879496 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01005702001 21385707 21389271 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA GSVIVG01037484001 12920298 12920903 GSVIVG01023681001 9110352 9113797 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01023681001 9110352 9113797 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01023681001 9110352 9113797 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01023681001 9110352 9113797 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023681001 9110352 9113797 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009456001 8532151 8534767 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01007694001 10309381 10311030 GSVIVG01037247001 16924481 16931362 GSVIVG01001006001 19870951 19874400 GSVIVG01010760001 22341410 22356380 GSVIVG01029193001 18714225 18720501 GSVIVG01022788001 16648893 16649144 GSVIVG01032753001 1009762 1011205 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01032753001 1009762 1011205 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01020339001 21087508 21109170 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with transfer RNA. IEA GO:0000049 tRNA binding GSVIVG01020339001 21087508 21109170 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with transfer RNA. IEA GO:0000049 tRNA binding GSVIVG01020339001 21087508 21109170 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with transfer RNA. IEA GO:0000049 tRNA binding GSVIVG01020339001 21087508 21109170 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with transfer RNA. IEA GO:0000049 tRNA binding GSVIVG01020339001 21087508 21109170 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020339001 21087508 21109170 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020339001 21087508 21109170 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020339001 21087508 21109170 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020339001 21087508 21109170 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01020339001 21087508 21109170 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01020339001 21087508 21109170 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01020339001 21087508 21109170 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01020339001 21087508 21109170 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01020339001 21087508 21109170 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01020339001 21087508 21109170 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01020339001 21087508 21109170 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01020339001 21087508 21109170 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe). IEA GO:0004826 phenylalanine-tRNA ligase activity GSVIVG01020339001 21087508 21109170 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe). IEA GO:0004826 phenylalanine-tRNA ligase activity GSVIVG01020339001 21087508 21109170 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe). IEA GO:0004826 phenylalanine-tRNA ligase activity GSVIVG01020339001 21087508 21109170 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe). IEA GO:0004826 phenylalanine-tRNA ligase activity GSVIVG01020339001 21087508 21109170 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020339001 21087508 21109170 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020339001 21087508 21109170 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020339001 21087508 21109170 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017006001 3404650 3408094 GSVIVG01001401001 24284451 24288563 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01001401001 24284451 24288563 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01001401001 24284451 24288563 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01001401001 24284451 24288563 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036120001 20423171 20431450 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01036120001 20423171 20431450 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01011656001 5559855 5567209 GSVIVG01037206001 27982615 27983482 GSVIVG01009864001 11917352 11919625 GSVIVG01024653001 7994669 7996737 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01005159001 18833889 18839913 GSVIVG01012144001 1079054 1081341 GSVIVG01008475001 1553719 1569449 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01008475001 1553719 1569449 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01008475001 1553719 1569449 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01008475001 1553719 1569449 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01008475001 1553719 1569449 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01008475001 1553719 1569449 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01037483001 12931174 12934461 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01037483001 12931174 12934461 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01037483001 12931174 12934461 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01037483001 12931174 12934461 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01001104001 22666634 22667976 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the reaction: pectin + n H2O = n methanol + pectate. IEA GO:0030599 pectinesterase activity GSVIVG01003706001 15166126 15197600 GSVIVG01021297001 3643628 3657896 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01021297001 3643628 3657896 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01021297001 3643628 3657896 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01021297001 3643628 3657896 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035456001 1391339 1403082 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01035456001 1391339 1403082 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01035456001 1391339 1403082 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01035456001 1391339 1403082 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01035456001 1391339 1403082 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035456001 1391339 1403082 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035456001 1391339 1403082 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01035456001 1391339 1403082 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01023690001 9389409 9394206 GSVIVG01011490001 30012394 30016919 GSVIVG01027787001 7762286 7763194 GSVIVG01032688001 1527055 1539043 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01032688001 1527055 1539043 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01032688001 1527055 1539043 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01032688001 1527055 1539043 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01007146001 30467699 30474275 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01007146001 30467699 30474275 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01007146001 30467699 30474275 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007146001 30467699 30474275 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007146001 30467699 30474275 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01007146001 30467699 30474275 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01020631001 3649392 3650615 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01020631001 3649392 3650615 Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. IEA GO:0008171 O-methyltransferase activity GSVIVG01020631001 3649392 3650615 The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01011462001 29803874 29808257 GSVIVG01028047001 3431929 3433055 GSVIVG01032121001 22470190 22477054 GSVIVG01000064001 3185338 3186328 GSVIVG01017143001 4552298 4555897 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017143001 4552298 4555897 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017143001 4552298 4555897 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017143001 4552298 4555897 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038403001 11821653 11822232 GSVIVG01028370001 6750380 6750838 GSVIVG01026647001 20771154 20773249 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01026647001 20771154 20773249 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01018763001 20111409 20111450 GSVIVG01023843001 3033390 3037328 GSVIVG01037296001 16316504 16320405 GSVIVG01018446001 14995536 15032836 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01018446001 14995536 15032836 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01016215001 6527099 6527191 GSVIVG01035406001 1062805 1064236 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01035406001 1062805 1064236 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01035406001 1062805 1064236 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01035406001 1062805 1064236 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01022478001 3512187 3515902 GSVIVG01027313001 16829238 16834515 GSVIVG01016583001 2633300 2635646 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01013678001 2480412 2485048 GSVIVG01004125001 15088322 15096478 GO:0008219 cell death A biological process that results in permanent cessation of all vital functions of a cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01037640001 6477611 6482034 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate. IEA GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity GSVIVG01037640001 6477611 6482034 GO:0008654 phospholipid biosynthetic process The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate. IEA GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity GSVIVG01037640001 6477611 6482034 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01037640001 6477611 6482034 GO:0008654 phospholipid biosynthetic process The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01020649001 3462915 3470985 GSVIVG01020135001 9978811 9987365 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017173001 4993413 4995290 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01017173001 4993413 4995290 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01007863001 8213729 8215907 GO:0006887 exocytosis A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell. This is the process whereby most molecules are secreted from eukaryotic cells. IEA GO:0000145 exocyst A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals. IEA GSVIVG01025417001 972785 983838 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023995001 1871442 1872348 GSVIVG01021531001 6712174 6713150 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01021531001 6712174 6713150 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds. IEA GO:0015035 protein disulfide oxidoreductase activity GSVIVG01014477001 4277012 4277346 GSVIVG01009969001 12914012 12933737 GSVIVG01037139001 28703323 28733078 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01037139001 28703323 28733078 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01037139001 28703323 28733078 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01010799001 22722239 22724013 GSVIVG01036457001 22303428 22307059 GSVIVG01012101001 1495867 1499100 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GSVIVG01008599001 514981 521034 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01008599001 514981 521034 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01030478001 6009243 6010711 GSVIVG01023682001 9114304 9133302 GSVIVG01001210001 761888 770381 GSVIVG01009845001 11742626 11743871 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with the neurotransmitter dopamine to initiate a change in cell activity. IEA GO:0004952 dopamine receptor activity GSVIVG01010830001 23134189 23149240 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01010830001 23134189 23149240 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01010830001 23134189 23149240 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010830001 23134189 23149240 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010830001 23134189 23149240 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01010830001 23134189 23149240 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01004404001 38411158 38412958 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01026764001 6577161 6577758 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01032749001 1045595 1052890 GSVIVG01022963001 17510489 17521707 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01022963001 17510489 17521707 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01022963001 17510489 17521707 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022963001 17510489 17521707 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025885001 27481319 27483541 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01001717001 449526 471234 GSVIVG01027018001 18542162 18547970 GSVIVG01003685001 12110122 12128723 GSVIVG01025220001 3098092 3107496 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025220001 3098092 3107496 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025220001 3098092 3107496 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01025220001 3098092 3107496 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01025220001 3098092 3107496 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01025220001 3098092 3107496 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01001856001 54903 59276 GSVIVG01012701001 832789 835873 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012701001 832789 835873 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020775001 2155556 2157608 GSVIVG01028534001 9362706 9364085 GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA GSVIVG01000960001 22299990 22304575 GSVIVG01000336001 11598411 11619004 GO:0006573 valine metabolic process The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid. IEA Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH + H+. IEA GO:0004491 methylmalonate-semialdehyde dehydrogenase (acylating) activity GSVIVG01000336001 11598411 11619004 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH + H+. IEA GO:0004491 methylmalonate-semialdehyde dehydrogenase (acylating) activity GSVIVG01000336001 11598411 11619004 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH + H+. IEA GO:0004491 methylmalonate-semialdehyde dehydrogenase (acylating) activity GSVIVG01000336001 11598411 11619004 GO:0006573 valine metabolic process The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01000336001 11598411 11619004 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01000336001 11598411 11619004 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01036440001 21931957 21942258 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01036440001 21931957 21942258 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01036440001 21931957 21942258 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01036440001 21931957 21942258 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01036440001 21931957 21942258 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01036440001 21931957 21942258 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01036440001 21931957 21942258 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01036440001 21931957 21942258 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01034928001 172088 179376 GSVIVG01010181001 16897462 16906512 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01017621001 2078370 2079158 GSVIVG01011828001 3798580 3803627 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029956001 2169774 2169944 GSVIVG01018436001 15204367 15205565 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01018436001 15204367 15205565 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01018436001 15204367 15205565 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01018436001 15204367 15205565 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01018436001 15204367 15205565 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01018436001 15204367 15205565 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01018436001 15204367 15205565 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01018436001 15204367 15205565 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01018436001 15204367 15205565 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01018436001 15204367 15205565 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01025539001 14202422 14204857 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025539001 14202422 14204857 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025539001 14202422 14204857 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01025539001 14202422 14204857 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01036682001 23954168 23955962 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01032938001 24438581 24451276 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032938001 24438581 24451276 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. IEA GO:0003987 acetate-CoA ligase activity GSVIVG01032938001 24438581 24451276 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with AMP, adenosine monophosphate. IEA GO:0016208 AMP binding GSVIVG01014083001 241617 242370 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014083001 241617 242370 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01011120001 1420740 1427299 GSVIVG01038706001 20803338 20807607 GSVIVG01024734001 7365268 7369025 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = D-myo-inositol 1,4,5-trisphosphate + diacylglycerol. IEA GO:0004435 phosphoinositide phospholipase C activity GSVIVG01024734001 7365268 7369025 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = D-myo-inositol 1,4,5-trisphosphate + diacylglycerol. IEA GO:0004435 phosphoinositide phospholipase C activity GSVIVG01024734001 7365268 7369025 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate. IEA GO:0004629 phospholipase C activity GSVIVG01024734001 7365268 7369025 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate. IEA GO:0004629 phospholipase C activity GSVIVG01024734001 7365268 7369025 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. IEA GO:0008081 phosphoric diester hydrolase activity GSVIVG01024734001 7365268 7369025 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. IEA GO:0008081 phosphoric diester hydrolase activity GSVIVG01016494001 3420904 3424708 GSVIVG01019624001 2035370 2036535 GSVIVG01014284001 2304393 2306969 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028122001 4003379 4006654 GSVIVG01001526001 1026091 1028874 GSVIVG01033785001 17857967 17859055 GO:0008283 cell proliferation The multiplication or reproduction of cells, resulting in the expansion of a cell population. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation. IEA GO:0008083 growth factor activity GSVIVG01001352001 23876897 23878462 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026621001 20960330 20962884 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01026621001 20960330 20962884 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01026621001 20960330 20962884 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01026621001 20960330 20962884 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01037807001 7710715 7711709 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009522 photosystem I A photosystem that contains an iron-sulfur reaction center associated with accessory pigments and electron carriers. In cyanobacteria and chloroplasts, photosystem I functions as a light-dependent plastocyanin-ferredoxin oxidoreductase, transferring electrons from plastocyanin to ferredoxin; in photosynthetic bacteria that have only a single type I photosystem, such as the green sulfur bacteria, electrons can go either to ferredoxin (Fd) -> NAD+ or to menaquinone (MK) -> Cytb/FeS -> Cytc555 -> photosystem I (cyclic photophosphorylation). IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01037807001 7710715 7711709 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0042651 thylakoid membrane The pigmented membrane of any thylakoid. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01003198001 7793091 7795209 GSVIVG01027412001 16926728 16928476 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01025208001 3297204 3302018 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01025208001 3297204 3302018 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01025208001 3297204 3302018 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01025208001 3297204 3302018 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01025208001 3297204 3302018 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01025208001 3297204 3302018 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01028351001 6483761 6490784 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01015861001 18544552 18544851 GSVIVG01022810001 16879684 16884544 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01022810001 16879684 16884544 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01031718001 3785857 3788100 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01024000001 1816069 1818709 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01024000001 1816069 1818709 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01024000001 1816069 1818709 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024000001 1816069 1818709 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01034019001 15795737 15800563 GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA GSVIVG01032093001 22774849 22779261 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01032093001 22774849 22779261 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01005092001 14445759 14480215 GO:0008104 protein localization Any process by which a protein is transported to, or maintained in, a specific location. IEA GSVIVG01033610001 19337997 19340055 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01033610001 19337997 19340055 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01033188001 9363169 9365026 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01033188001 9363169 9365026 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01028645001 11524803 11525042 GSVIVG01016162001 7289701 7300305 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016162001 7289701 7300305 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01037418001 14126556 14129950 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01019768001 3156563 3161990 GSVIVG01013180001 7019468 7043516 GO:0016226 iron-sulfur cluster assembly The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036505001 22768564 22768923 GSVIVG01031691001 20251497 20251637 GSVIVG01030204001 10497833 10502987 GSVIVG01024398001 2093624 2099985 GSVIVG01031218001 1107441 1109201 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031218001 1107441 1109201 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031218001 1107441 1109201 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031218001 1107441 1109201 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031218001 1107441 1109201 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01031218001 1107441 1109201 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01017305001 6544703 6553874 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01035673001 3191979 3196494 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01037530001 12043331 12069631 GSVIVG01023302001 19947481 19948741 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01023302001 19947481 19948741 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01023302001 19947481 19948741 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01023302001 19947481 19948741 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01008223001 4502588 4505873 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA GSVIVG01030120001 10028914 10031710 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01030120001 10028914 10031710 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01030120001 10028914 10031710 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01017985001 5290150 5291427 GO:0016068 type I hypersensitivity An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells or basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines. IEA GSVIVG01025396001 1095357 1110322 GSVIVG01010904001 15936369 15940173 GSVIVG01012583001 4296618 4297380 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01012583001 4296618 4297380 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012583001 4296618 4297380 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters. IEA GO:0004523 ribonuclease H activity GSVIVG01003117001 7374871 7413498 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003117001 7374871 7413498 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01003117001 7374871 7413498 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01003117001 7374871 7413498 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001214001 734677 735964 GSVIVG01025834001 11393657 11397581 GSVIVG01037134001 28763886 28768659 GO:0005578 proteinaceous extracellular matrix A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01037134001 28763886 28768659 GO:0005578 proteinaceous extracellular matrix A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01037134001 28763886 28768659 GO:0005578 proteinaceous extracellular matrix A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus. IEA The action of a molecule that contributes to the structural integrity of the extracellular matrix. IEA GO:0005201 extracellular matrix structural constituent GSVIVG01010157001 16525845 16535560 GSVIVG01013191001 6915186 6925613 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01013191001 6915186 6925613 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01013191001 6915186 6925613 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051537 2 iron, 2 sulfur cluster binding GSVIVG01010104001 15551007 15556266 Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01027849001 8609833 8611014 GSVIVG01025899001 27396665 27397644 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01021722001 10081576 10087103 GSVIVG01009441001 8391930 8393726 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01009441001 8391930 8393726 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01009441001 8391930 8393726 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01009441001 8391930 8393726 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01009441001 8391930 8393726 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01009441001 8391930 8393726 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01025423001 903605 911945 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01025423001 903605 911945 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01025423001 903605 911945 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01022256001 17903000 17920841 GSVIVG01019386001 213715 224334 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035797001 4436277 4443299 GSVIVG01030181001 10770593 10775412 GO:0006414 translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Functions in chain elongation during polypeptide synthesis at the ribosome. IEA GO:0003746 translation elongation factor activity GSVIVG01004437001 38525249 38525954 GO:0008283 cell proliferation The multiplication or reproduction of cells, resulting in the expansion of a cell population. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation. IEA GO:0008083 growth factor activity GSVIVG01010060001 14353829 14356884 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010060001 14353829 14356884 GO:0006284 base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010060001 14353829 14356884 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the hydrolysis of alkylated DNA; only recognizes and removes the alkylated base 3-methyladenine by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site. IEA GO:0008725 DNA-3-methyladenine glycosylase I activity GSVIVG01010060001 14353829 14356884 GO:0006284 base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. IEA Catalysis of the hydrolysis of alkylated DNA; only recognizes and removes the alkylated base 3-methyladenine by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site. IEA GO:0008725 DNA-3-methyladenine glycosylase I activity GSVIVG01032090001 22812330 22816847 GSVIVG01016592001 2559302 2568627 GO:0006011 UDP-glucose metabolic process The chemical reactions and pathways involving UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01038414001 11960802 11962317 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01020922001 17090553 17104721 GSVIVG01033623001 19153732 19155357 GSVIVG01019614001 1964782 1965840 GSVIVG01037231001 17123855 17143658 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01037231001 17123855 17143658 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01021796001 7275721 7279576 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01021796001 7275721 7279576 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01021796001 7275721 7279576 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals. IEA GO:0008519 ammonium transmembrane transporter activity GSVIVG01021796001 7275721 7279576 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals. IEA GO:0008519 ammonium transmembrane transporter activity GSVIVG01020001001 11779064 11779369 GSVIVG01020966001 16253689 16260410 GSVIVG01009890001 12151852 12158339 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005667 transcription factor complex A protein complex, distinct from RNA polymerase, that associates with DNA at promoters or at cis-acting regulatory sequences, by direct binding or by interaction with other DNA-binding polypeptides or complexes, and regulates transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01015425001 3553469 3557622 GSVIVG01005734001 13940199 13942568 GSVIVG01025688001 12950058 12953148 GSVIVG01035090001 1400042 1407785 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01035090001 1400042 1407785 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01015141001 1330507 1332127 GSVIVG01030353001 8277837 8281079 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018125001 6777136 6780522 GO:0006302 double-strand break repair The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01018125001 6777136 6780522 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01018125001 6777136 6780522 GO:0006302 double-strand break repair The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018125001 6777136 6780522 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01010727001 21854708 21857506 GSVIVG01034442001 16209520 16210316 GSVIVG01006110001 41646482 41648164 GSVIVG01023684001 9172153 9186879 GO:0007049 cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01016447001 3808859 3821300 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01016447001 3808859 3821300 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01016447001 3808859 3821300 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01016447001 3808859 3821300 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01003388001 9791751 9792551 GSVIVG01007630001 11102025 11102394 GSVIVG01037024001 8793246 8793890 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01037024001 8793246 8793890 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01035727001 3695825 3742593 GSVIVG01002709001 35954856 35955970 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01009621001 9946872 9949051 GSVIVG01027872001 8866527 8872218 GSVIVG01005706001 21414138 21414967 GSVIVG01009550001 9306605 9313005 GSVIVG01017768001 3301315 3305240 GSVIVG01038224001 24467983 24470845 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01038224001 24467983 24470845 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01038224001 24467983 24470845 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01038224001 24467983 24470845 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01038224001 24467983 24470845 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01038224001 24467983 24470845 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01038224001 24467983 24470845 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01038224001 24467983 24470845 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031234001 995776 1001644 GSVIVG01010896001 16080037 16085813 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010896001 16080037 16085813 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010896001 16080037 16085813 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010896001 16080037 16085813 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010896001 16080037 16085813 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010896001 16080037 16085813 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010896001 16080037 16085813 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010896001 16080037 16085813 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010896001 16080037 16085813 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010896001 16080037 16085813 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010896001 16080037 16085813 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01010896001 16080037 16085813 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01010896001 16080037 16085813 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01010896001 16080037 16085813 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01010896001 16080037 16085813 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01010896001 16080037 16085813 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01010896001 16080037 16085813 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01010896001 16080037 16085813 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01010896001 16080037 16085813 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01010896001 16080037 16085813 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01010896001 16080037 16085813 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient. IEA GO:0005261 cation channel activity GSVIVG01010896001 16080037 16085813 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient. IEA GO:0005261 cation channel activity GSVIVG01010896001 16080037 16085813 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient. IEA GO:0005261 cation channel activity GSVIVG01010896001 16080037 16085813 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient. IEA GO:0005261 cation channel activity GSVIVG01010896001 16080037 16085813 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient. IEA GO:0005261 cation channel activity GSVIVG01010896001 16080037 16085813 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient. IEA GO:0005261 cation channel activity GSVIVG01010896001 16080037 16085813 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient. IEA GO:0005261 cation channel activity GSVIVG01010896001 16080037 16085813 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient. IEA GO:0005261 cation channel activity GSVIVG01010896001 16080037 16085813 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient. IEA GO:0005261 cation channel activity GSVIVG01010896001 16080037 16085813 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient. IEA GO:0005261 cation channel activity GSVIVG01010896001 16080037 16085813 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010896001 16080037 16085813 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010896001 16080037 16085813 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010896001 16080037 16085813 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010896001 16080037 16085813 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010896001 16080037 16085813 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010896001 16080037 16085813 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010896001 16080037 16085813 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010896001 16080037 16085813 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010896001 16080037 16085813 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010896001 16080037 16085813 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01010896001 16080037 16085813 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01010896001 16080037 16085813 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01010896001 16080037 16085813 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01010896001 16080037 16085813 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01010896001 16080037 16085813 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01010896001 16080037 16085813 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01010896001 16080037 16085813 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01010896001 16080037 16085813 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01010896001 16080037 16085813 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01010896001 16080037 16085813 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01010896001 16080037 16085813 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01010896001 16080037 16085813 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01010896001 16080037 16085813 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01010896001 16080037 16085813 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01010896001 16080037 16085813 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01010896001 16080037 16085813 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01010896001 16080037 16085813 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01010896001 16080037 16085813 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01010896001 16080037 16085813 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01010896001 16080037 16085813 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. IEA GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GSVIVG01010896001 16080037 16085813 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. IEA GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GSVIVG01010896001 16080037 16085813 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. IEA GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GSVIVG01010896001 16080037 16085813 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. IEA GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GSVIVG01010896001 16080037 16085813 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. IEA GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GSVIVG01010896001 16080037 16085813 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. IEA GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GSVIVG01010896001 16080037 16085813 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. IEA GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GSVIVG01010896001 16080037 16085813 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. IEA GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GSVIVG01010896001 16080037 16085813 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. IEA GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GSVIVG01010896001 16080037 16085813 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. IEA GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GSVIVG01010896001 16080037 16085813 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01010896001 16080037 16085813 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01010896001 16080037 16085813 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01010896001 16080037 16085813 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01010896001 16080037 16085813 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01010896001 16080037 16085813 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01010896001 16080037 16085813 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01010896001 16080037 16085813 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01010896001 16080037 16085813 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01010896001 16080037 16085813 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01010896001 16080037 16085813 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01010896001 16080037 16085813 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01010896001 16080037 16085813 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01010896001 16080037 16085813 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01010896001 16080037 16085813 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01010896001 16080037 16085813 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01010896001 16080037 16085813 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01010896001 16080037 16085813 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01010896001 16080037 16085813 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01010896001 16080037 16085813 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01010896001 16080037 16085813 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01010896001 16080037 16085813 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01010896001 16080037 16085813 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01010896001 16080037 16085813 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01010896001 16080037 16085813 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01010896001 16080037 16085813 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01010896001 16080037 16085813 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01010896001 16080037 16085813 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01010896001 16080037 16085813 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01010896001 16080037 16085813 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01027774001 7580440 7581363 GSVIVG01005299001 20398875 20399913 GSVIVG01033712001 18402845 18412633 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004185 serine-type carboxypeptidase activity GSVIVG01033712001 18402845 18412633 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004185 serine-type carboxypeptidase activity GSVIVG01033712001 18402845 18412633 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the reaction: pectin + n H2O = n methanol + pectate. IEA GO:0030599 pectinesterase activity GSVIVG01033712001 18402845 18412633 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the reaction: pectin + n H2O = n methanol + pectate. IEA GO:0030599 pectinesterase activity GSVIVG01022253001 17857238 17870799 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01022253001 17857238 17870799 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01022253001 17857238 17870799 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01015505001 4296049 4306315 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01015505001 4296049 4306315 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01003661001 11869351 11875353 Catalysis of the removal of a phosphate group from phosphorylated myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol. IEA GO:0004437 inositol or phosphatidylinositol phosphatase activity GSVIVG01036333001 3887653 3888101 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01021293001 3591467 3595236 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01021293001 3591467 3595236 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01021293001 3591467 3595236 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01021293001 3591467 3595236 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009373001 7866961 7871581 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01009373001 7866961 7871581 GO:0048193 Golgi vesicle transport The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033543001 19866408 19867472 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033543001 19866408 19867472 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01033543001 19866408 19867472 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01028352001 6491532 6491897 GSVIVG01018058001 5884388 5899015 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018058001 5884388 5899015 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018058001 5884388 5899015 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018058001 5884388 5899015 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018058001 5884388 5899015 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01018058001 5884388 5899015 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01018058001 5884388 5899015 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01018058001 5884388 5899015 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01018058001 5884388 5899015 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018058001 5884388 5899015 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018058001 5884388 5899015 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018058001 5884388 5899015 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018058001 5884388 5899015 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of calcium (Ca) ions from one side of a membrane to the other. IEA GO:0015085 calcium ion transmembrane transporter activity GSVIVG01018058001 5884388 5899015 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of calcium (Ca) ions from one side of a membrane to the other. IEA GO:0015085 calcium ion transmembrane transporter activity GSVIVG01018058001 5884388 5899015 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of calcium (Ca) ions from one side of a membrane to the other. IEA GO:0015085 calcium ion transmembrane transporter activity GSVIVG01018058001 5884388 5899015 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of calcium (Ca) ions from one side of a membrane to the other. IEA GO:0015085 calcium ion transmembrane transporter activity GSVIVG01018058001 5884388 5899015 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01018058001 5884388 5899015 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01018058001 5884388 5899015 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01018058001 5884388 5899015 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01018058001 5884388 5899015 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01018058001 5884388 5899015 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01018058001 5884388 5899015 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01018058001 5884388 5899015 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01027641001 14768737 14769341 GO:0006869 lipid transport The directed movement of lipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GSVIVG01029993001 8770585 8777088 GSVIVG01009339001 7541102 7547150 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01009339001 7541102 7547150 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01003536001 192497 193716 GSVIVG01017302001 6501025 6504291 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01010594001 16208718 16210275 GSVIVG01016388001 4299875 4306061 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01015511001 4337102 4342191 GSVIVG01033562001 19740517 19747957 GO:0006506 GPI anchor biosynthetic process The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol moiety is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate moiety, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01033562001 19740517 19747957 GO:0006506 GPI anchor biosynthetic process The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol moiety is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate moiety, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01033562001 19740517 19747957 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01033562001 19740517 19747957 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01033562001 19740517 19747957 GO:0006506 GPI anchor biosynthetic process The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol moiety is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate moiety, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + phosphatidylinositol = UDP + N-acetyl-D-glucosaminylphosphatidylinositol. IEA GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity GSVIVG01033562001 19740517 19747957 GO:0006506 GPI anchor biosynthetic process The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol moiety is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate moiety, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + phosphatidylinositol = UDP + N-acetyl-D-glucosaminylphosphatidylinositol. IEA GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity GSVIVG01033562001 19740517 19747957 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + phosphatidylinositol = UDP + N-acetyl-D-glucosaminylphosphatidylinositol. IEA GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity GSVIVG01033562001 19740517 19747957 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + phosphatidylinositol = UDP + N-acetyl-D-glucosaminylphosphatidylinositol. IEA GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity GSVIVG01026835001 20100041 20102187 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026835001 20100041 20102187 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026835001 20100041 20102187 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026835001 20100041 20102187 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026835001 20100041 20102187 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01026835001 20100041 20102187 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01027555001 15654856 15688221 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01027555001 15654856 15688221 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01027555001 15654856 15688221 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01027555001 15654856 15688221 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01010854001 23365000 23368333 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01010854001 23365000 23368333 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01003801001 272383 274655 GSVIVG01020531001 4750768 4757408 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01032751001 1027118 1037127 GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the endohydrolysis of the N,N'-diacetylchitobiosyl unit in high-mannose glycopeptides and glycoproteins containing the -[Man(GlcNAc)2]Asn-structure. One N-acetyl-D-glucosamine residue remains attached to the protein; the rest of the oligosaccharide is released intact. IEA GO:0033925 mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity GSVIVG01032830001 408581 417657 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01032830001 408581 417657 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01032830001 408581 417657 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032830001 408581 417657 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032830001 408581 417657 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01032830001 408581 417657 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01012855001 6216524 6216613 GSVIVG01029945001 1954732 1955641 GSVIVG01016578001 2656260 2658810 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01016578001 2656260 2658810 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01016578001 2656260 2658810 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01016578001 2656260 2658810 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01016578001 2656260 2658810 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA IEA GO:0016986 transcription initiation factor activity GSVIVG01016578001 2656260 2658810 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA IEA GO:0016986 transcription initiation factor activity GSVIVG01016578001 2656260 2658810 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA IEA GO:0016986 transcription initiation factor activity GSVIVG01016578001 2656260 2658810 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA IEA GO:0016986 transcription initiation factor activity GSVIVG01014340001 2789196 2790307 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01020999001 15612760 15655133 GSVIVG01017149001 4681771 4684819 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017149001 4681771 4684819 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017149001 4681771 4684819 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017149001 4681771 4684819 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020671001 3207671 3217255 GSVIVG01001400001 24282716 24284448 GSVIVG01007568001 11917357 11918658 GSVIVG01029819001 15314614 15315444 GO:0007205 activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway The initiation of the activity of the inactive enzyme protein kinase C as the result of a series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol 3-phosphate. IEA GO:0004143 diacylglycerol kinase activity GSVIVG01015768001 17178217 17218628 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01015768001 17178217 17218628 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015768001 17178217 17218628 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01015768001 17178217 17218628 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01036247001 8133051 8134585 GSVIVG01021650001 8748783 8753791 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0042651 thylakoid membrane The pigmented membrane of any thylakoid. IEA Catalysis of the reaction: reduced ferredoxin + NADP+ = oxidized ferredoxin + NADPH + H+. IEA GO:0004324 ferredoxin-NADP+ reductase activity GSVIVG01021650001 8748783 8753791 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0042651 thylakoid membrane The pigmented membrane of any thylakoid. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021650001 8748783 8753791 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0042651 thylakoid membrane The pigmented membrane of any thylakoid. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01021650001 8748783 8753791 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0042651 thylakoid membrane The pigmented membrane of any thylakoid. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01012385001 307938 311000 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012385001 307938 311000 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012385001 307938 311000 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01012385001 307938 311000 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01012385001 307938 311000 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01012385001 307938 311000 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01021577001 7367051 7368558 GSVIVG01026652001 20669032 20711919 GSVIVG01012778001 23406742 23419601 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01018724001 20384129 20390368 GSVIVG01037062001 8241138 8242407 GSVIVG01025613001 13568175 13569453 GSVIVG01021110001 1500882 1505824 GSVIVG01037734001 7349367 7366438 Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity. IEA GO:0004721 phosphoprotein phosphatase activity GSVIVG01037734001 7349367 7366438 Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01037734001 7349367 7366438 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01016330001 4972456 4973665 GSVIVG01008134001 5512215 5513288 GSVIVG01033064001 25486818 25489754 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01027451001 16645033 16646455 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01027451001 16645033 16646455 Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. IEA GO:0008171 O-methyltransferase activity GSVIVG01027451001 16645033 16646455 The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01017439001 8525562 8536177 GO:0006571 tyrosine biosynthetic process The chemical reactions and pathways resulting in the formation of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01017439001 8525562 8536177 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01017439001 8525562 8536177 GO:0006571 tyrosine biosynthetic process The chemical reactions and pathways resulting in the formation of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid. IEA Catalysis of the reaction: prephenate + NADP+ = 4-hydroxyphenylpyruvate + CO2 + NADPH + H+. IEA GO:0004665 prephenate dehydrogenase (NADP+) activity GSVIVG01017439001 8525562 8536177 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: prephenate + NADP+ = 4-hydroxyphenylpyruvate + CO2 + NADPH + H+. IEA GO:0004665 prephenate dehydrogenase (NADP+) activity GSVIVG01017439001 8525562 8536177 GO:0006571 tyrosine biosynthetic process The chemical reactions and pathways resulting in the formation of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017439001 8525562 8536177 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01010765001 22392732 22398235 GSVIVG01007628001 11103650 11105095 GSVIVG01016723001 661938 664024 GO:0006887 exocytosis A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell. This is the process whereby most molecules are secreted from eukaryotic cells. IEA GO:0000145 exocyst A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals. IEA GSVIVG01016530001 3083106 3084858 GSVIVG01031749001 4031293 4040609 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01027583001 15340666 15344250 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01027583001 15340666 15344250 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01027583001 15340666 15344250 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01027583001 15340666 15344250 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01003420001 14831122 14837193 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01017717001 2869464 2876265 GSVIVG01017580001 10955290 10959002 GSVIVG01008523001 1116769 1128710 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. IEA GO:0004618 phosphoglycerate kinase activity GSVIVG01008523001 1116769 1128710 GO:0007030 Golgi organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. IEA GO:0004618 phosphoglycerate kinase activity GSVIVG01008523001 1116769 1128710 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. IEA GO:0004618 phosphoglycerate kinase activity GSVIVG01023507001 10692856 10811597 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01030804001 16356705 16360130 GSVIVG01010139001 16157069 16202539 GO:0009063 cellular amino acid catabolic process The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01010139001 16157069 16202539 GO:0009234 menaquinone biosynthetic process The chemical reactions and pathways resulting in the formation of any of the menaquinones, any of the quinone-derived compounds synthesized by intestinal bacteria. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones have vitamin K activity and are known as vitamin K2. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01010139001 16157069 16202539 GO:0009063 cellular amino acid catabolic process The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010139001 16157069 16202539 GO:0009234 menaquinone biosynthetic process The chemical reactions and pathways resulting in the formation of any of the menaquinones, any of the quinone-derived compounds synthesized by intestinal bacteria. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones have vitamin K activity and are known as vitamin K2. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010139001 16157069 16202539 GO:0009063 cellular amino acid catabolic process The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. IEA GO:0016836 hydro-lyase activity GSVIVG01010139001 16157069 16202539 GO:0009234 menaquinone biosynthetic process The chemical reactions and pathways resulting in the formation of any of the menaquinones, any of the quinone-derived compounds synthesized by intestinal bacteria. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones have vitamin K activity and are known as vitamin K2. IEA Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. IEA GO:0016836 hydro-lyase activity GSVIVG01034684001 7599222 7624536 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01034684001 7599222 7624536 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01034684001 7599222 7624536 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the reaction: ATP + pyruvate = ADP + phosphoenolpyruvate. IEA GO:0004743 pyruvate kinase activity GSVIVG01034684001 7599222 7624536 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01034684001 7599222 7624536 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01034684001 7599222 7624536 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Interacting selectively and non-covalently with potassium (K+) ions. IEA GO:0030955 potassium ion binding GSVIVG01015279001 2356205 2357712 GSVIVG01011726001 4757211 4758358 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GSVIVG01011726001 4757211 4758358 GO:0009607 response to biotic stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism. IEA GSVIVG01008147001 5376018 5377433 Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate. IEA GO:0008146 sulfotransferase activity GSVIVG01037130001 28796898 28797942 GSVIVG01012820001 5736757 5739075 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01005095001 14492022 14493170 GSVIVG01003996001 14148241 14152990 GSVIVG01016191001 6865527 6870248 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. IEA GO:0016597 amino acid binding GSVIVG01029878001 892733 896421 GO:0009416 response to light stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01029878001 892733 896421 GO:0009416 response to light stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01019749001 2940011 2941068 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01019749001 2940011 2941068 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031995001 23685723 23690271 GSVIVG01024972001 5599392 5603809 GSVIVG01030566001 6790965 6801813 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01033883001 17033457 17043399 GO:0007154 cell communication Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033883001 17033457 17043399 GO:0007154 cell communication Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. IEA Interacting selectively and non-covalently with any inositol-containing glycerophospholipid. Phosphatidylinositol (PtdIns) and its phosphorylated derivatives are collectively referred to as phosphoinositides (PIs). IEA GO:0035091 phosphoinositide binding GSVIVG01033928001 16637902 16649900 GSVIVG01020484001 18708699 18709996 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009654 oxygen evolving complex A complex, composed of a cluster of manganese, calcium and chloride ions bound to extrinsic proteins, that catalyzes the splitting of water to O2 and 4 H+. In cyanobacteria there are five extrinsic proteins in OEC (PsbO, PsbP-like, PsbQ-like, PsbU and PsbV), while in plants there are only three (PsbO, PsbP and PsbQ). IEA GSVIVG01020484001 18708699 18709996 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0042651 thylakoid membrane The pigmented membrane of any thylakoid. IEA GSVIVG01002630001 35504285 35505586 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01023419001 12348595 12348732 GSVIVG01004102001 14820378 14845197 GSVIVG01000717001 138160 145185 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01002362001 34390217 34393271 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: 2 H2O2 = O2 + 2 H2O. IEA GO:0004096 catalase activity GSVIVG01002362001 34390217 34393271 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2 H2O2 = O2 + 2 H2O. IEA GO:0004096 catalase activity GSVIVG01026159001 13141394 13145163 GO:0016459 myosin complex A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. IEA Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate. IEA GO:0003774 motor activity GSVIVG01026159001 13141394 13145163 GO:0016459 myosin complex A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020458001 19094251 19106285 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01020458001 19094251 19106285 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01020458001 19094251 19106285 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01020458001 19094251 19106285 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01011664001 5414342 5433963 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01005975001 23070771 23072458 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01005975001 23070771 23072458 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01005975001 23070771 23072458 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01005975001 23070771 23072458 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01003743001 7554225 7554385 GSVIVG01000491001 14894755 14897484 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01000491001 14894755 14897484 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01000491001 14894755 14897484 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01000491001 14894755 14897484 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01015149001 1381431 1386842 GSVIVG01026649001 20738356 20739576 GSVIVG01013452001 347645 353985 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01008154001 5258946 5270412 GSVIVG01017017001 3474654 3478940 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01017017001 3474654 3478940 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01017017001 3474654 3478940 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017017001 3474654 3478940 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017017001 3474654 3478940 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017017001 3474654 3478940 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017017001 3474654 3478940 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01017017001 3474654 3478940 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01014065001 44337 45540 GO:0006278 RNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01014065001 44337 45540 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01014065001 44337 45540 GO:0006278 RNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01014065001 44337 45540 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01014065001 44337 45540 GO:0006278 RNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time. IEA GO:0003964 RNA-directed DNA polymerase activity GSVIVG01014065001 44337 45540 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time. IEA GO:0003964 RNA-directed DNA polymerase activity GSVIVG01014065001 44337 45540 GO:0006278 RNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. IEA GO:0004519 endonuclease activity GSVIVG01014065001 44337 45540 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. IEA GO:0004519 endonuclease activity GSVIVG01033775001 17962761 17965626 GSVIVG01022163001 17147446 17153603 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01022163001 17147446 17153603 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). IEA GO:0016769 transferase activity, transferring nitrogenous groups GSVIVG01022163001 17147446 17153603 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01018197001 13342406 13344186 GSVIVG01030844001 17476414 17478327 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01035121001 1602118 1614345 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035121001 1602118 1614345 GO:0046949 fatty-acyl-CoA biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty-acyl group. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035121001 1602118 1614345 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01035121001 1602118 1614345 GO:0046949 fatty-acyl-CoA biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty-acyl group. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01035121001 1602118 1614345 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01035121001 1602118 1614345 GO:0046949 fatty-acyl-CoA biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty-acyl group. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01035121001 1602118 1614345 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with lipoic acid, 1,2-dithiolane-3-pentanoic acid. IEA GO:0031405 lipoic acid binding GSVIVG01035121001 1602118 1614345 GO:0046949 fatty-acyl-CoA biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty-acyl group. IEA Interacting selectively and non-covalently with lipoic acid, 1,2-dithiolane-3-pentanoic acid. IEA GO:0031405 lipoic acid binding GSVIVG01035121001 1602118 1614345 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2-methylpropanoyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-[2-methylpropanoyl]dihydrolipoyl)lysine. IEA GO:0043754 dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity GSVIVG01035121001 1602118 1614345 GO:0046949 fatty-acyl-CoA biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty-acyl group. IEA Catalysis of the reaction: 2-methylpropanoyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-[2-methylpropanoyl]dihydrolipoyl)lysine. IEA GO:0043754 dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity GSVIVG01035121001 1602118 1614345 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. IEA GO:0048037 cofactor binding GSVIVG01035121001 1602118 1614345 GO:0046949 fatty-acyl-CoA biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty-acyl group. IEA Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. IEA GO:0048037 cofactor binding GSVIVG01024788001 6946476 6947765 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01024788001 6946476 6947765 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01005818001 22093627 22094745 GSVIVG01023831001 3142872 3151289 GO:0006464 protein modification process The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01023831001 3142872 3151289 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01023831001 3142872 3151289 GO:0006464 protein modification process The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01023831001 3142872 3151289 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01023831001 3142872 3151289 GO:0006464 protein modification process The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023831001 3142872 3151289 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023831001 3142872 3151289 GO:0006464 protein modification process The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). IEA Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond. IEA GO:0008641 small protein activating enzyme activity GSVIVG01023831001 3142872 3151289 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond. IEA GO:0008641 small protein activating enzyme activity GSVIVG01015829001 17992264 17995838 GO:0006313 transposition, DNA-mediated Any process involved in a type of transpositional recombination which occurs via a DNA intermediate. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01015829001 17992264 17995838 GO:0006313 transposition, DNA-mediated Any process involved in a type of transpositional recombination which occurs via a DNA intermediate. IEA Catalysis of the transposition of transposable elements or transposons. Transposases are involved in site-specific DNA recombination required for transposition in bacteria and other organisms. IEA GO:0004803 transposase activity GSVIVG01015829001 17992264 17995838 GO:0006313 transposition, DNA-mediated Any process involved in a type of transpositional recombination which occurs via a DNA intermediate. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01032943001 24484982 24492325 GSVIVG01017894001 4453167 4455917 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01001347001 23815317 23845626 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01013407001 653647 659479 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01038051001 17054531 17055451 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. IEA GO:0004364 glutathione transferase activity GSVIVG01012518001 451954 465083 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01012518001 451954 465083 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01012518001 451954 465083 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01016699001 452713 458157 GSVIVG01032748001 1057242 1061647 GSVIVG01010024001 13539023 13541804 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010024001 13539023 13541804 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010024001 13539023 13541804 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01010024001 13539023 13541804 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01010024001 13539023 13541804 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01010024001 13539023 13541804 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01010024001 13539023 13541804 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01010024001 13539023 13541804 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01010024001 13539023 13541804 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01010024001 13539023 13541804 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01010024001 13539023 13541804 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01010024001 13539023 13541804 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01030222001 10305172 10307033 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01027653001 14614856 14617208 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Stops, prevents or reduces the activity of an enzyme. IEA GO:0004857 enzyme inhibitor activity GSVIVG01027653001 14614856 14617208 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01027653001 14614856 14617208 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the reaction: pectin + n H2O = n methanol + pectate. IEA GO:0030599 pectinesterase activity GSVIVG01027653001 14614856 14617208 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue. IEA GO:0045330 aspartyl esterase activity GSVIVG01037949001 11427457 11427941 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035941001 6237415 6238065 GSVIVG01022721001 15558752 15559784 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. IEA GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GSVIVG01021275001 3278240 3281378 GSVIVG01016338001 4811076 4829687 GSVIVG01037972001 11859652 11910014 GO:0042147 retrograde transport, endosome to Golgi The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036277001 7612811 7613875 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01036277001 7612811 7613875 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01036277001 7612811 7613875 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01036277001 7612811 7613875 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0009523 photosystem II A photosystem that contains a pheophytin-quinone reaction center with associated accessory pigments and electron carriers. In cyanobacteria and chloroplasts, in the presence of light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone, whereas other photosynthetic bacteria carry out anoxygenic photosynthesis and oxidize other compounds to re-reduce the photoreaction center. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01000528001 13719220 13791705 GSVIVG01027191001 17145789 17147069 GSVIVG01029933001 1641016 1685282 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01029933001 1641016 1685282 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01017845001 3978962 3984862 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01002636001 35561049 35565845 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01002636001 35561049 35565845 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01002636001 35561049 35565845 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035864001 5011754 5014271 GO:0048268 clathrin coat assembly The process by which clathrin triskelia are assembled into the ordered structure known as a clathrin cage. IEA GO:0030118 clathrin coat A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes. IEA Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester. IEA GO:0005543 phospholipid binding GSVIVG01035864001 5011754 5014271 GO:0048268 clathrin coat assembly The process by which clathrin triskelia are assembled into the ordered structure known as a clathrin cage. IEA GO:0030118 clathrin coat A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes. IEA Interacting selectively and non-covalently with phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. IEA GO:0005545 phosphatidylinositol binding GSVIVG01035864001 5011754 5014271 GO:0048268 clathrin coat assembly The process by which clathrin triskelia are assembled into the ordered structure known as a clathrin cage. IEA GO:0030118 clathrin coat A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes. IEA Interacting selectively and non-covalently with a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles. IEA GO:0030276 clathrin binding GSVIVG01011086001 1714278 1715913 GSVIVG01017061001 3864923 3871846 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01017061001 3864923 3871846 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01017061001 3864923 3871846 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01017061001 3864923 3871846 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01017061001 3864923 3871846 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01017061001 3864923 3871846 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01017061001 3864923 3871846 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01017061001 3864923 3871846 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01017061001 3864923 3871846 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01017061001 3864923 3871846 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01017061001 3864923 3871846 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01017061001 3864923 3871846 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01017061001 3864923 3871846 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017061001 3864923 3871846 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017061001 3864923 3871846 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017061001 3864923 3871846 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017061001 3864923 3871846 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017061001 3864923 3871846 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017061001 3864923 3871846 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017061001 3864923 3871846 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017061001 3864923 3871846 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017061001 3864923 3871846 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017061001 3864923 3871846 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017061001 3864923 3871846 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017061001 3864923 3871846 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01017061001 3864923 3871846 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01017061001 3864923 3871846 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01017061001 3864923 3871846 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01017061001 3864923 3871846 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01017061001 3864923 3871846 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01028151001 4226622 4231596 GSVIVG01017804001 3584705 3592030 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01017804001 3584705 3592030 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01012980001 10833512 10835788 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01012980001 10833512 10835788 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01012980001 10833512 10835788 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01012980001 10833512 10835788 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor. IEA GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GSVIVG01012980001 10833512 10835788 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01001304001 5166429 5166605 GSVIVG01028302001 5910684 5913078 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01029711001 13516703 13520175 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01036501001 22700290 22702204 GSVIVG01006118001 41765184 41766695 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01006118001 41765184 41766695 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01006118001 41765184 41766695 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01006118001 41765184 41766695 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009356001 7692729 7708608 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01009356001 7692729 7708608 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01009384001 7913344 7915123 GSVIVG01020726001 2646825 2655025 GO:0006904 vesicle docking involved in exocytosis The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis. IEA GSVIVG01020726001 2646825 2655025 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GSVIVG01013740001 8010191 8012475 Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor. IEA GO:0003950 NAD+ ADP-ribosyltransferase activity GSVIVG01003309001 8911979 8912912 GSVIVG01008376001 2703715 2704981 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. IEA GO:0004364 glutathione transferase activity GSVIVG01031188001 1370206 1374560 GSVIVG01012699001 804943 811930 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012699001 804943 811930 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012699001 804943 811930 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012699001 804943 811930 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01012699001 804943 811930 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01021808001 7108217 7111721 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01027166001 17300322 17304725 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01027166001 17300322 17304725 GO:0009725 response to hormone stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01027166001 17300322 17304725 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01027166001 17300322 17304725 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01027166001 17300322 17304725 GO:0009725 response to hormone stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01027166001 17300322 17304725 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01028648001 11575003 11583437 GSVIVG01021011001 15339882 15340519 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01021011001 15339882 15340519 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01016974001 3096510 3097802 GSVIVG01006749001 28067440 28068726 GSVIVG01020734001 2540851 2542435 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01020734001 2540851 2542435 Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. IEA GO:0008171 O-methyltransferase activity GSVIVG01020734001 2540851 2542435 The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01018300001 11498970 11504729 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01018300001 11498970 11504729 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01012880001 6473688 6487240 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GSVIVG01036067001 21118170 21128534 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01020091001 10409284 10411107 GSVIVG01015245001 2085587 2087072 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01015245001 2085587 2087072 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01015245001 2085587 2087072 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. IEA GO:0008171 O-methyltransferase activity GSVIVG01032764001 938312 941575 GSVIVG01003617001 11308117 11315071 GSVIVG01017652001 2390891 2394802 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01019502001 1164898 1168589 GSVIVG01025259001 2631858 2647190 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01010771001 22444843 22453266 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01010771001 22444843 22453266 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01010771001 22444843 22453266 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01003122001 7448443 7450554 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01003122001 7448443 7450554 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01001203001 840895 843953 GSVIVG01028743001 19230435 19234443 GSVIVG01004794001 117104 118883 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01004794001 117104 118883 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). IEA GO:0016769 transferase activity, transferring nitrogenous groups GSVIVG01004794001 117104 118883 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + methylthioadenosine. IEA GO:0016847 1-aminocyclopropane-1-carboxylate synthase activity GSVIVG01004794001 117104 118883 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01013131001 7878002 7879125 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01013131001 7878002 7879125 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01013131001 7878002 7879125 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01031773001 4262854 4270341 GSVIVG01017848001 3999815 4002525 GSVIVG01022484001 3674027 3674233 GSVIVG01014072001 114618 145720 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01015932001 15295827 15296086 GSVIVG01010030001 13650264 13655312 GSVIVG01015046001 704010 706403 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01015046001 704010 706403 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01015046001 704010 706403 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01015046001 704010 706403 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013496001 1858487 1886223 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01010109001 15664463 15666483 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010109001 15664463 15666483 GO:0006284 base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010109001 15664463 15666483 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the hydrolysis of alkylated DNA; only recognizes and removes the alkylated base 3-methyladenine by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site. IEA GO:0008725 DNA-3-methyladenine glycosylase I activity GSVIVG01010109001 15664463 15666483 GO:0006284 base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. IEA Catalysis of the hydrolysis of alkylated DNA; only recognizes and removes the alkylated base 3-methyladenine by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site. IEA GO:0008725 DNA-3-methyladenine glycosylase I activity GSVIVG01003646001 11619455 11620981 GSVIVG01027486001 16407196 16411129 Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. IEA GO:0008171 O-methyltransferase activity GSVIVG01020329001 21265508 21281525 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01016291001 5479517 5501570 GO:0006541 glutamine metabolic process The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016291001 5479517 5501570 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016291001 5479517 5501570 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016291001 5479517 5501570 GO:0009396 folic acid and derivative biosynthetic process The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016291001 5479517 5501570 GO:0006541 glutamine metabolic process The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid. IEA Catalysis of the reaction: chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate. IEA GO:0004049 anthranilate synthase activity GSVIVG01016291001 5479517 5501570 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate. IEA GO:0004049 anthranilate synthase activity GSVIVG01016291001 5479517 5501570 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate. IEA GO:0004049 anthranilate synthase activity GSVIVG01016291001 5479517 5501570 GO:0009396 folic acid and derivative biosynthetic process The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. IEA Catalysis of the reaction: chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate. IEA GO:0004049 anthranilate synthase activity GSVIVG01016291001 5479517 5501570 GO:0006541 glutamine metabolic process The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid. IEA Catalysis of the cleavage of a C-C bond by other means than by hydrolysis or oxidation, of a 3-hydroxy acid. IEA GO:0016833 oxo-acid-lyase activity GSVIVG01016291001 5479517 5501570 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of a C-C bond by other means than by hydrolysis or oxidation, of a 3-hydroxy acid. IEA GO:0016833 oxo-acid-lyase activity GSVIVG01016291001 5479517 5501570 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the cleavage of a C-C bond by other means than by hydrolysis or oxidation, of a 3-hydroxy acid. IEA GO:0016833 oxo-acid-lyase activity GSVIVG01016291001 5479517 5501570 GO:0009396 folic acid and derivative biosynthetic process The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. IEA Catalysis of the cleavage of a C-C bond by other means than by hydrolysis or oxidation, of a 3-hydroxy acid. IEA GO:0016833 oxo-acid-lyase activity GSVIVG01008331001 3189753 3194345 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01008331001 3189753 3194345 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008331001 3189753 3194345 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01028703001 19642629 19664832 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01028703001 19642629 19664832 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01028703001 19642629 19664832 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01028703001 19642629 19664832 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01028703001 19642629 19664832 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01028703001 19642629 19664832 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01028703001 19642629 19664832 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028703001 19642629 19664832 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028703001 19642629 19664832 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01028703001 19642629 19664832 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01028703001 19642629 19664832 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01028703001 19642629 19664832 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01018095001 6455677 6489255 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018095001 6455677 6489255 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017207001 5412814 5430837 GSVIVG01029765001 14399527 14402117 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01029765001 14399527 14402117 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01029765001 14399527 14402117 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01029765001 14399527 14402117 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01000525001 13691793 13693411 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the reaction: pectin + n H2O = n methanol + pectate. IEA GO:0030599 pectinesterase activity GSVIVG01024554001 8882429 8886021 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01024554001 8882429 8886021 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01024554001 8882429 8886021 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01024554001 8882429 8886021 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01037008001 8986184 8986955 GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA GSVIVG01011668001 5374311 5375923 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01010156001 16513246 16515107 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01010156001 16513246 16515107 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01010156001 16513246 16515107 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01010156001 16513246 16515107 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01027568001 15505640 15506749 GSVIVG01031959001 5719179 5724128 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031959001 5719179 5724128 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01031959001 5719179 5724128 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01008477001 1529100 1531743 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0000808 origin recognition complex A multisubunit complex that is located at the replication origins of a chromosome. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01008477001 1529100 1531743 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01008477001 1529100 1531743 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005761 mitochondrial ribosome A ribosome found in the mitochondrion of a eukaryotic cell; contains a characteristic set of proteins distinct from those of cytosolic ribosomes. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01008477001 1529100 1531743 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0015935 small ribosomal subunit The smaller of the two subunits of a ribosome. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01008477001 1529100 1531743 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0000808 origin recognition complex A multisubunit complex that is located at the replication origins of a chromosome. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01008477001 1529100 1531743 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01008477001 1529100 1531743 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0005761 mitochondrial ribosome A ribosome found in the mitochondrion of a eukaryotic cell; contains a characteristic set of proteins distinct from those of cytosolic ribosomes. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01008477001 1529100 1531743 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0015935 small ribosomal subunit The smaller of the two subunits of a ribosome. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01008477001 1529100 1531743 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0000808 origin recognition complex A multisubunit complex that is located at the replication origins of a chromosome. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01008477001 1529100 1531743 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01008477001 1529100 1531743 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005761 mitochondrial ribosome A ribosome found in the mitochondrion of a eukaryotic cell; contains a characteristic set of proteins distinct from those of cytosolic ribosomes. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01008477001 1529100 1531743 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0015935 small ribosomal subunit The smaller of the two subunits of a ribosome. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01008477001 1529100 1531743 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0000808 origin recognition complex A multisubunit complex that is located at the replication origins of a chromosome. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01008477001 1529100 1531743 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01008477001 1529100 1531743 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0005761 mitochondrial ribosome A ribosome found in the mitochondrion of a eukaryotic cell; contains a characteristic set of proteins distinct from those of cytosolic ribosomes. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01008477001 1529100 1531743 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0015935 small ribosomal subunit The smaller of the two subunits of a ribosome. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01000889001 3488130 3497849 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01000889001 3488130 3497849 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01012465001 1250453 1256555 GSVIVG01000788001 153373 154997 GSVIVG01028216001 4684209 4685074 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01025508001 183245 227075 GSVIVG01034756001 9086197 9091461 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01025352001 1607345 1614985 GSVIVG01016833001 1767625 1767940 GSVIVG01011379001 29167521 29176890 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01011379001 29167521 29176890 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01011379001 29167521 29176890 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01007818001 8732711 8739622 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of the terminal 1,2-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2). IEA GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity GSVIVG01007818001 8732711 8739622 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01026475001 22974120 22978475 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01001146001 1320240 1322417 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA GSVIVG01001146001 1320240 1322417 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GSVIVG01011565001 6433123 6436008 GO:0006536 glutamate metabolic process The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01011565001 6433123 6436008 GO:0019752 carboxylic acid metabolic process The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01011565001 6433123 6436008 GO:0006536 glutamate metabolic process The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid. IEA Catalysis of the reaction: L-glutamate = 4-aminobutanoate + CO2. IEA GO:0004351 glutamate decarboxylase activity GSVIVG01011565001 6433123 6436008 GO:0019752 carboxylic acid metabolic process The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). IEA Catalysis of the reaction: L-glutamate = 4-aminobutanoate + CO2. IEA GO:0004351 glutamate decarboxylase activity GSVIVG01011565001 6433123 6436008 GO:0006536 glutamate metabolic process The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01011565001 6433123 6436008 GO:0019752 carboxylic acid metabolic process The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01011565001 6433123 6436008 GO:0006536 glutamate metabolic process The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid. IEA Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. IEA GO:0016831 carboxy-lyase activity GSVIVG01011565001 6433123 6436008 GO:0019752 carboxylic acid metabolic process The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). IEA Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. IEA GO:0016831 carboxy-lyase activity GSVIVG01011565001 6433123 6436008 GO:0006536 glutamate metabolic process The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01011565001 6433123 6436008 GO:0019752 carboxylic acid metabolic process The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01003649001 11664514 11678382 GSVIVG01033521001 20043857 20045963 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01035930001 6067869 6071553 GSVIVG01028561001 9833371 9839020 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01028561001 9833371 9839020 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01025788001 11857567 11860728 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025788001 11857567 11860728 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01025788001 11857567 11860728 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01025788001 11857567 11860728 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01024631001 8246592 8249000 GO:0006887 exocytosis A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell. This is the process whereby most molecules are secreted from eukaryotic cells. IEA GO:0000145 exocyst A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals. IEA GSVIVG01019633001 2104835 2108803 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GSVIVG01023353001 19405011 19406408 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01023353001 19405011 19406408 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01023353001 19405011 19406408 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01023353001 19405011 19406408 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012238001 302206 305739 GO:0009396 folic acid and derivative biosynthetic process The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. IEA Catalysis of the reaction: ATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine = AMP + 2-amino-7,8-dihydro-4-hydroxy-6-(diphosphooxymethyl)pteridine. IEA GO:0003848 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity GSVIVG01012238001 302206 305739 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of the reaction: ATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine = AMP + 2-amino-7,8-dihydro-4-hydroxy-6-(diphosphooxymethyl)pteridine. IEA GO:0003848 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity GSVIVG01012238001 302206 305739 GO:0009396 folic acid and derivative biosynthetic process The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. IEA Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate. IEA GO:0004156 dihydropteroate synthase activity GSVIVG01012238001 302206 305739 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate. IEA GO:0004156 dihydropteroate synthase activity GSVIVG01011698001 5018050 5026418 GSVIVG01035459001 1418711 1420503 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01033931001 16621527 16626844 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005667 transcription factor complex A protein complex, distinct from RNA polymerase, that associates with DNA at promoters or at cis-acting regulatory sequences, by direct binding or by interaction with other DNA-binding polypeptides or complexes, and regulates transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01025729001 12541804 12543638 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019004001 17890575 17904569 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019004001 17890575 17904569 Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity. IEA GO:0004721 phosphoprotein phosphatase activity GSVIVG01018514001 14001400 14003593 GSVIVG01001414001 18882118 18882775 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001414001 18882118 18882775 Catalysis of the elimination of H2S or substituted H2S. IEA GO:0016846 carbon-sulfur lyase activity GSVIVG01001414001 18882118 18882775 Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01021224001 2720041 2723551 GSVIVG01029404001 16330182 16454350 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01029404001 16330182 16454350 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01029404001 16330182 16454350 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01029404001 16330182 16454350 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01029404001 16330182 16454350 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01029404001 16330182 16454350 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01024732001 7375147 7382236 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = D-myo-inositol 1,4,5-trisphosphate + diacylglycerol. IEA GO:0004435 phosphoinositide phospholipase C activity GSVIVG01024732001 7375147 7382236 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = D-myo-inositol 1,4,5-trisphosphate + diacylglycerol. IEA GO:0004435 phosphoinositide phospholipase C activity GSVIVG01024732001 7375147 7382236 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate. IEA GO:0004629 phospholipase C activity GSVIVG01024732001 7375147 7382236 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate. IEA GO:0004629 phospholipase C activity GSVIVG01024732001 7375147 7382236 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. IEA GO:0008081 phosphoric diester hydrolase activity GSVIVG01024732001 7375147 7382236 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. IEA GO:0008081 phosphoric diester hydrolase activity GSVIVG01015034001 613339 620215 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01015034001 613339 620215 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01015034001 613339 620215 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01015034001 613339 620215 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015034001 613339 620215 Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01015034001 613339 620215 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01038261001 24776997 24786203 GO:0009231 riboflavin biosynthetic process The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). IEA GO:0009349 riboflavin synthase complex An flavoprotein that catalyzes the reaction the breakdown of dimethyl(ribityl)lumazine to form riboflavin and ribitylamino-amino-dihydroxypyrimidine. IEA GSVIVG01029868001 777087 784687 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01029868001 777087 784687 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01031724001 3836734 3850849 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01031724001 3836734 3850849 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01031724001 3836734 3850849 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01031724001 3836734 3850849 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01027372001 15573700 15574034 GO:0006909 phagocytosis The process whereby phagocytes engulf external particulate material. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles. IEA GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA GSVIVG01034092001 15204286 15222976 GO:0006223 uracil salvage Any process that generates uracil, 2,4-dioxopyrimidine, from derivatives of it without de novo synthesis. IEA Catalysis of the reaction: UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate. IEA GO:0004845 uracil phosphoribosyltransferase activity GSVIVG01034092001 15204286 15222976 GO:0009116 nucleoside metabolic process The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine). IEA Catalysis of the reaction: UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate. IEA GO:0004845 uracil phosphoribosyltransferase activity GSVIVG01031434001 18633153 18637191 GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly The aggregation, arrangement and bonding together of a proton-transporting ATP synthase in the mitochondrial inner membrane. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA GSVIVG01023642001 8350267 8368462 GO:0006413 translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. IEA Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. IEA GO:0003743 translation initiation factor activity GSVIVG01015850001 18343142 18371399 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01015850001 18343142 18371399 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01015850001 18343142 18371399 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01015850001 18343142 18371399 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01004933001 21626788 21633564 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity. IEA GO:0004721 phosphoprotein phosphatase activity GSVIVG01004933001 21626788 21633564 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity. IEA GO:0004721 phosphoprotein phosphatase activity GSVIVG01030984001 20267119 20267379 GSVIVG01010993001 2367917 2369607 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01030482001 6048341 6054656 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01030482001 6048341 6054656 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01030482001 6048341 6054656 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01030482001 6048341 6054656 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01030482001 6048341 6054656 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01030482001 6048341 6054656 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01030482001 6048341 6054656 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030482001 6048341 6054656 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037751001 7512781 7517479 GSVIVG01016106001 19070829 19086523 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016106001 19070829 19086523 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01014590001 5405275 5406294 GSVIVG01025790001 11817435 11821789 GSVIVG01018505001 14225405 14227114 GSVIVG01001794001 3273932 3274535 GSVIVG01025213001 3261098 3266377 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025213001 3261098 3266377 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01023441001 11862308 11889003 GO:0007010 cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. IEA GO:0005778 peroxisomal membrane The lipid bilayer surrounding a peroxisome. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01023441001 11862308 11889003 GO:0007031 peroxisome organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules. IEA GO:0005778 peroxisomal membrane The lipid bilayer surrounding a peroxisome. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01023441001 11862308 11889003 GO:0007010 cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. IEA GO:0005778 peroxisomal membrane The lipid bilayer surrounding a peroxisome. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023441001 11862308 11889003 GO:0007031 peroxisome organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules. IEA GO:0005778 peroxisomal membrane The lipid bilayer surrounding a peroxisome. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023441001 11862308 11889003 GO:0007010 cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. IEA GO:0005778 peroxisomal membrane The lipid bilayer surrounding a peroxisome. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01023441001 11862308 11889003 GO:0007031 peroxisome organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules. IEA GO:0005778 peroxisomal membrane The lipid bilayer surrounding a peroxisome. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008979001 4003411 4004435 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01008979001 4003411 4004435 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01008979001 4003411 4004435 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01008979001 4003411 4004435 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01033092001 25655360 25658365 GSVIVG01033421001 20848501 20850417 GSVIVG01029164001 18994246 18996244 GSVIVG01017952001 5040289 5043717 GO:0009308 amine metabolic process The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01017952001 5040289 5043717 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01017952001 5040289 5043717 GO:0009308 amine metabolic process The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. IEA Catalysis of the reaction: R-CH2-NH2 + H2O + O2 = R-CHO + NH3 + H2O2. IEA GO:0008131 amine oxidase activity GSVIVG01017952001 5040289 5043717 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: R-CH2-NH2 + H2O + O2 = R-CHO + NH3 + H2O2. IEA GO:0008131 amine oxidase activity GSVIVG01017952001 5040289 5043717 GO:0009308 amine metabolic process The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. IEA Interacting selectively and non-covalently with a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds. IEA GO:0048038 quinone binding GSVIVG01017952001 5040289 5043717 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds. IEA GO:0048038 quinone binding GSVIVG01010380001 20007761 20013929 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01038360001 13583576 13630846 GSVIVG01022895001 18199891 18209795 GO:0007067 mitosis A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell. IEA GO:0000775 chromosome, centromeric region The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome. IEA GSVIVG01021220001 2677202 2706936 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01021220001 2677202 2706936 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01021220001 2677202 2706936 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01021220001 2677202 2706936 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019472001 914881 916167 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01035858001 4942548 4950572 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: 2 H2O2 = O2 + 2 H2O. IEA GO:0004096 catalase activity GSVIVG01035858001 4942548 4950572 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2 H2O2 = O2 + 2 H2O. IEA GO:0004096 catalase activity GSVIVG01035858001 4942548 4950572 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01035858001 4942548 4950572 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01035858001 4942548 4950572 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01035858001 4942548 4950572 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01025559001 14063164 14066114 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. IEA GO:0004364 glutathione transferase activity GSVIVG01037667001 6691784 6695136 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035640001 2903931 2905762 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01035640001 2903931 2905762 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01035640001 2903931 2905762 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01035640001 2903931 2905762 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01027473001 16465782 16469473 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01013692001 2709744 2714717 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01013692001 2709744 2714717 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01030681001 13462876 13464826 GSVIVG01028394001 7058091 7062281 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01028394001 7058091 7062281 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01028394001 7058091 7062281 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01033899001 16875916 16905339 GSVIVG01033574001 19635901 19649002 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033574001 19635901 19649002 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: D-arabinono-1,4-lactone + O2 = dehydro-D-arabinono-1,4-lactone + H2O2. IEA GO:0003885 D-arabinono-1,4-lactone oxidase activity GSVIVG01033574001 19635901 19649002 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033574001 19635901 19649002 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: L-galactono-1,4-lactone + 2 ferricytochrome c = L-ascorbate + 2 ferrocytochrome c. IEA GO:0016633 galactonolactone dehydrogenase activity GSVIVG01033574001 19635901 19649002 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01011949001 2717670 2719510 GSVIVG01021211001 2574232 2575192 GSVIVG01027898001 9167986 9170443 GSVIVG01016413001 4149115 4151088 GSVIVG01007634001 11013564 11013698 GSVIVG01022239001 17761409 17769272 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01022239001 17761409 17769272 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01022239001 17761409 17769272 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01022239001 17761409 17769272 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01022118001 16732778 16733411 GSVIVG01015738001 16654192 16659203 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01015738001 16654192 16659203 GO:0006419 alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01015738001 16654192 16659203 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala). IEA GO:0004813 alanine-tRNA ligase activity GSVIVG01015738001 16654192 16659203 GO:0006419 alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala). IEA GO:0004813 alanine-tRNA ligase activity GSVIVG01015738001 16654192 16659203 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015738001 16654192 16659203 GO:0006419 alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038591001 21635865 21637951 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01038591001 21635865 21637951 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01003176001 5962592 5966795 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01007732001 9828365 9840079 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01007732001 9828365 9840079 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01034794001 21737277 21739446 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GSVIVG01034601001 14671869 14684852 GSVIVG01019539001 1453847 1458053 GO:0006183 GTP biosynthetic process The chemical reactions and pathways resulting in the formation of GTP, guanosine triphosphate. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01019539001 1453847 1458053 GO:0006228 UTP biosynthetic process The chemical reactions and pathways resulting in the formation of UTP, uridine (5'-)triphosphate. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01019539001 1453847 1458053 GO:0006241 CTP biosynthetic process The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01019539001 1453847 1458053 GO:0006183 GTP biosynthetic process The chemical reactions and pathways resulting in the formation of GTP, guanosine triphosphate. IEA Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. IEA GO:0004550 nucleoside diphosphate kinase activity GSVIVG01019539001 1453847 1458053 GO:0006228 UTP biosynthetic process The chemical reactions and pathways resulting in the formation of UTP, uridine (5'-)triphosphate. IEA Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. IEA GO:0004550 nucleoside diphosphate kinase activity GSVIVG01019539001 1453847 1458053 GO:0006241 CTP biosynthetic process The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate. IEA Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. IEA GO:0004550 nucleoside diphosphate kinase activity GSVIVG01019539001 1453847 1458053 GO:0006183 GTP biosynthetic process The chemical reactions and pathways resulting in the formation of GTP, guanosine triphosphate. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019539001 1453847 1458053 GO:0006228 UTP biosynthetic process The chemical reactions and pathways resulting in the formation of UTP, uridine (5'-)triphosphate. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019539001 1453847 1458053 GO:0006241 CTP biosynthetic process The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019539001 1453847 1458053 GO:0006183 GTP biosynthetic process The chemical reactions and pathways resulting in the formation of GTP, guanosine triphosphate. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01019539001 1453847 1458053 GO:0006228 UTP biosynthetic process The chemical reactions and pathways resulting in the formation of UTP, uridine (5'-)triphosphate. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01019539001 1453847 1458053 GO:0006241 CTP biosynthetic process The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01019539001 1453847 1458053 GO:0006183 GTP biosynthetic process The chemical reactions and pathways resulting in the formation of GTP, guanosine triphosphate. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01019539001 1453847 1458053 GO:0006228 UTP biosynthetic process The chemical reactions and pathways resulting in the formation of UTP, uridine (5'-)triphosphate. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01019539001 1453847 1458053 GO:0006241 CTP biosynthetic process The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01019852001 3838090 3841971 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01019852001 3838090 3841971 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01019852001 3838090 3841971 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01019852001 3838090 3841971 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01004028001 1502144 1513029 GSVIVG01030438001 5553056 5555560 GSVIVG01004674001 39564152 39568010 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha1-adrenergic receptors; the activity involves transmitting the signal to the Gq alpha subunit of a heterotrimeric G protein. IEA GO:0004937 alpha1-adrenergic receptor activity GSVIVG01029548001 21709227 21726296 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01029440001 22879356 22886287 GSVIVG01038418001 12006027 12006360 GO:0006909 phagocytosis The process whereby phagocytes engulf external particulate material. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles. IEA GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA GSVIVG01007278001 31225304 31230205 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01007278001 31225304 31230205 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01007278001 31225304 31230205 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the formation of a 2,3-epoxide in squalene. IEA GO:0004506 squalene monooxygenase activity GSVIVG01007278001 31225304 31230205 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the formation of a 2,3-epoxide in squalene. IEA GO:0004506 squalene monooxygenase activity GSVIVG01007278001 31225304 31230205 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01007278001 31225304 31230205 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01007278001 31225304 31230205 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01007278001 31225304 31230205 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01028866001 17986030 17989757 GSVIVG01023724001 10134887 10137254 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01023724001 10134887 10137254 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01004810001 83833 89606 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01004810001 83833 89606 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01031495001 17955504 17959506 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031495001 17955504 17959506 GO:0006004 fucose metabolic process The chemical reactions and pathways involving fucose, or 6-deoxygalactose, which has two enantiomers, D-fucose and L-fucose. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031495001 17955504 17959506 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: an alpha-L-fucoside + H2O = an alcohol + L-fucose. IEA GO:0004560 alpha-L-fucosidase activity GSVIVG01031495001 17955504 17959506 GO:0006004 fucose metabolic process The chemical reactions and pathways involving fucose, or 6-deoxygalactose, which has two enantiomers, D-fucose and L-fucose. IEA Catalysis of the reaction: an alpha-L-fucoside + H2O = an alcohol + L-fucose. IEA GO:0004560 alpha-L-fucosidase activity GSVIVG01031495001 17955504 17959506 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01031495001 17955504 17959506 GO:0006004 fucose metabolic process The chemical reactions and pathways involving fucose, or 6-deoxygalactose, which has two enantiomers, D-fucose and L-fucose. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01028428001 7445666 7447162 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01000354001 11939928 11940490 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01000354001 11939928 11940490 GO:0006935 chemotaxis The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01000354001 11939928 11940490 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01000354001 11939928 11940490 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with anaphylatoxin to initiate a change in cell activity. IEA GO:0004942 anaphylatoxin receptor activity GSVIVG01000354001 11939928 11940490 GO:0006935 chemotaxis The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with anaphylatoxin to initiate a change in cell activity. IEA GO:0004942 anaphylatoxin receptor activity GSVIVG01000354001 11939928 11940490 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with anaphylatoxin to initiate a change in cell activity. IEA GO:0004942 anaphylatoxin receptor activity GSVIVG01000354001 11939928 11940490 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000354001 11939928 11940490 GO:0006935 chemotaxis The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000354001 11939928 11940490 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036990001 9168263 9182594 GSVIVG01006024001 23214985 23216989 GSVIVG01021687001 9536363 9541714 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01021687001 9536363 9541714 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01021687001 9536363 9541714 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01021687001 9536363 9541714 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037897001 6548597 6549754 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01030995001 20520289 20527173 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01030995001 20520289 20527173 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01030995001 20520289 20527173 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01030995001 20520289 20527173 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024280001 511711 512953 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01024280001 511711 512953 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01024280001 511711 512953 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01024280001 511711 512953 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01023173001 21647419 21655095 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023173001 21647419 21655095 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023173001 21647419 21655095 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023173001 21647419 21655095 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023173001 21647419 21655095 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023173001 21647419 21655095 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023173001 21647419 21655095 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01023173001 21647419 21655095 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01034333001 17921288 17926846 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01034333001 17921288 17926846 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01034333001 17921288 17926846 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01034333001 17921288 17926846 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01022869001 18552858 18553629 GSVIVG01017542001 10245402 10246292 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01017542001 10245402 10246292 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01006909001 29058931 29063621 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O. IEA GO:0004129 cytochrome-c oxidase activity GSVIVG01006909001 29058931 29063621 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O. IEA GO:0004129 cytochrome-c oxidase activity GSVIVG01006909001 29058931 29063621 GO:0022904 respiratory electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O. IEA GO:0004129 cytochrome-c oxidase activity GSVIVG01006909001 29058931 29063621 GO:0022904 respiratory electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O. IEA GO:0004129 cytochrome-c oxidase activity GSVIVG01006909001 29058931 29063621 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01006909001 29058931 29063621 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01006909001 29058931 29063621 GO:0022904 respiratory electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01006909001 29058931 29063621 GO:0022904 respiratory electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01006909001 29058931 29063621 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01006909001 29058931 29063621 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01006909001 29058931 29063621 GO:0022904 respiratory electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01006909001 29058931 29063621 GO:0022904 respiratory electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01006909001 29058931 29063621 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01006909001 29058931 29063621 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01006909001 29058931 29063621 GO:0022904 respiratory electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01006909001 29058931 29063621 GO:0022904 respiratory electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01023199001 21230860 21234361 GSVIVG01019807001 3496354 3498474 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01001158001 1183383 1188619 GO:0008380 RNA splicing The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA. IEA GO:0005681 spliceosomal complex Any of a series of ribonucleoprotein complexes that contain RNA and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the splicing of a messenger RNA primary transcript to excise an intron. IEA GSVIVG01033613001 19298905 19304538 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033613001 19298905 19304538 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2-phosphoglycolate + H2O = glycolate + phosphate. IEA GO:0008967 phosphoglycolate phosphatase activity GSVIVG01033613001 19298905 19304538 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01006796001 262786 263088 GSVIVG01001091001 22586178 22593857 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01001091001 22586178 22593857 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01001091001 22586178 22593857 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01003179001 5934427 5937550 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004197 cysteine-type endopeptidase activity GSVIVG01003179001 5934427 5937550 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01035091001 1413786 1420996 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion. IEA GO:0004091 carboxylesterase activity GSVIVG01035091001 1413786 1420996 GO:0016042 lipid catabolic process The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion. IEA GO:0004091 carboxylesterase activity GSVIVG01035091001 1413786 1420996 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion. IEA GO:0004806 triglyceride lipase activity GSVIVG01035091001 1413786 1420996 GO:0016042 lipid catabolic process The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion. IEA GO:0004806 triglyceride lipase activity GSVIVG01019560001 1617930 1624103 GSVIVG01024162001 679190 684422 GSVIVG01025719001 12677750 12684231 GSVIVG01015969001 16428179 16471625 GSVIVG01019558001 1605079 1609494 GSVIVG01030994001 20500606 20518957 GSVIVG01021636001 8501860 8506094 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01021636001 8501860 8506094 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01021636001 8501860 8506094 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01021636001 8501860 8506094 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01021636001 8501860 8506094 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013694001 2720579 2724686 GO:0009405 pathogenesis The set of specific processes that generate the ability of an organism to cause disease in another. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01013694001 2720579 2724686 GO:0009405 pathogenesis The set of specific processes that generate the ability of an organism to cause disease in another. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01013694001 2720579 2724686 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01013694001 2720579 2724686 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01013694001 2720579 2724686 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01013694001 2720579 2724686 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01013694001 2720579 2724686 GO:0009405 pathogenesis The set of specific processes that generate the ability of an organism to cause disease in another. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01013694001 2720579 2724686 GO:0009405 pathogenesis The set of specific processes that generate the ability of an organism to cause disease in another. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01013694001 2720579 2724686 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01013694001 2720579 2724686 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01013694001 2720579 2724686 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01013694001 2720579 2724686 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01013694001 2720579 2724686 GO:0009405 pathogenesis The set of specific processes that generate the ability of an organism to cause disease in another. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01013694001 2720579 2724686 GO:0009405 pathogenesis The set of specific processes that generate the ability of an organism to cause disease in another. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01013694001 2720579 2724686 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01013694001 2720579 2724686 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01013694001 2720579 2724686 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01013694001 2720579 2724686 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01013694001 2720579 2724686 GO:0009405 pathogenesis The set of specific processes that generate the ability of an organism to cause disease in another. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01013694001 2720579 2724686 GO:0009405 pathogenesis The set of specific processes that generate the ability of an organism to cause disease in another. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01013694001 2720579 2724686 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01013694001 2720579 2724686 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01013694001 2720579 2724686 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01013694001 2720579 2724686 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01012624001 155483 156963 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01012624001 155483 156963 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01012624001 155483 156963 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01012624001 155483 156963 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01024225001 24426 40615 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01024225001 24426 40615 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01024225001 24426 40615 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01024225001 24426 40615 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012441001 831496 836124 GSVIVG01036051001 21361924 21362550 GSVIVG01035868001 5060733 5066712 GSVIVG01024917001 6049347 6050274 GSVIVG01034097001 15161601 15170258 GO:0006561 proline biosynthetic process The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01034097001 15161601 15170258 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01034097001 15161601 15170258 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01034097001 15161601 15170258 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01034097001 15161601 15170258 GO:0006561 proline biosynthetic process The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-glutamate = ADP + L-glutamate 5-phosphate. IEA GO:0004349 glutamate 5-kinase activity GSVIVG01034097001 15161601 15170258 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-glutamate = ADP + L-glutamate 5-phosphate. IEA GO:0004349 glutamate 5-kinase activity GSVIVG01034097001 15161601 15170258 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-glutamate = ADP + L-glutamate 5-phosphate. IEA GO:0004349 glutamate 5-kinase activity GSVIVG01034097001 15161601 15170258 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-glutamate = ADP + L-glutamate 5-phosphate. IEA GO:0004349 glutamate 5-kinase activity GSVIVG01034097001 15161601 15170258 GO:0006561 proline biosynthetic process The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: L-glutamate 5-semialdehyde + phosphate + NADP+ = L-gamma-glutamyl 5-phosphate + NADPH + H+. IEA GO:0004350 glutamate-5-semialdehyde dehydrogenase activity GSVIVG01034097001 15161601 15170258 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: L-glutamate 5-semialdehyde + phosphate + NADP+ = L-gamma-glutamyl 5-phosphate + NADPH + H+. IEA GO:0004350 glutamate-5-semialdehyde dehydrogenase activity GSVIVG01034097001 15161601 15170258 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: L-glutamate 5-semialdehyde + phosphate + NADP+ = L-gamma-glutamyl 5-phosphate + NADPH + H+. IEA GO:0004350 glutamate-5-semialdehyde dehydrogenase activity GSVIVG01034097001 15161601 15170258 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: L-glutamate 5-semialdehyde + phosphate + NADP+ = L-gamma-glutamyl 5-phosphate + NADPH + H+. IEA GO:0004350 glutamate-5-semialdehyde dehydrogenase activity GSVIVG01034097001 15161601 15170258 GO:0006561 proline biosynthetic process The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01034097001 15161601 15170258 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01034097001 15161601 15170258 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01034097001 15161601 15170258 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01019509001 1211765 1218586 GSVIVG01035609001 2669216 2670256 GSVIVG01012846001 6061779 6063674 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01012846001 6061779 6063674 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01012325001 169828 170334 GSVIVG01019892001 4282246 4283948 GSVIVG01003898001 13348037 13350379 GSVIVG01016588001 2599623 2602003 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016588001 2599623 2602003 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01029943001 1937153 1940033 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01029943001 1937153 1940033 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01006282001 24495964 24496104 GSVIVG01003984001 26481801 26483502 GSVIVG01025658001 13208773 13211555 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01027757001 7455361 7457511 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01027757001 7455361 7457511 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01013127001 7918085 7919566 GO:0032957 inositol trisphosphate metabolic process The chemical reactions and pathways involving myo-inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with three phosphate groups attached. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01013127001 7918085 7919566 GO:0032957 inositol trisphosphate metabolic process The chemical reactions and pathways involving myo-inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with three phosphate groups attached. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013127001 7918085 7919566 GO:0032957 inositol trisphosphate metabolic process The chemical reactions and pathways involving myo-inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with three phosphate groups attached. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reactions: ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate and ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate. IEA GO:0035300 inositol-1,3,4-trisphosphate 5/6-kinase activity GSVIVG01013127001 7918085 7919566 GO:0032957 inositol trisphosphate metabolic process The chemical reactions and pathways involving myo-inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with three phosphate groups attached. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: 1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP. IEA GO:0047325 inositol tetrakisphosphate 1-kinase activity GSVIVG01014191001 1360589 1367394 GSVIVG01029537001 21856828 21857945 GSVIVG01024776001 7052113 7052997 GSVIVG01031554001 17226267 17231076 GSVIVG01031370001 19464015 19467635 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01031370001 19464015 19467635 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01031370001 19464015 19467635 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01031370001 19464015 19467635 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023904001 2568801 2571113 GSVIVG01016239001 6049536 6055742 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01016239001 6049536 6055742 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01016239001 6049536 6055742 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01016239001 6049536 6055742 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030767001 15623508 15628240 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01030767001 15623508 15628240 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01030767001 15623508 15628240 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01028923001 17473366 17494545 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036924001 17518996 17520457 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GSVIVG01021768001 10851943 10855465 GSVIVG01021433001 5291324 5293768 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01021433001 5291324 5293768 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01006102001 41501570 41502029 GSVIVG01015170001 1530192 1542903 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01015170001 1530192 1542903 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01015170001 1530192 1542903 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01015170001 1530192 1542903 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01029190001 18735010 18737944 GSVIVG01003027001 37566189 37568791 GSVIVG01019905001 4381266 4389110 GSVIVG01009883001 12116588 12118772 GSVIVG01009280001 6923748 6925293 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01004726001 15554323 15559705 GO:0006298 mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01004726001 15554323 15559705 GO:0006298 mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. IEA Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches. IEA GO:0030983 mismatched DNA binding GSVIVG01033321001 21520048 21526760 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01033321001 21520048 21526760 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033321001 21520048 21526760 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01033321001 21520048 21526760 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01030462001 5789627 5793748 GSVIVG01014447001 3859502 3860403 GSVIVG01011616001 5940758 5942086 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01011616001 5940758 5942086 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01020509001 18194905 18198944 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01020509001 18194905 18198944 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01020509001 18194905 18198944 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01020509001 18194905 18198944 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01009098001 5020555 5021751 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01009098001 5020555 5021751 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01026050001 25307237 25310613 GSVIVG01031366001 19536917 19538630 GO:0006414 translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01031366001 19536917 19538630 GO:0006414 translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01016002001 17182168 17187214 GSVIVG01005295001 20332150 20332293 GSVIVG01035546001 2187374 2190925 GO:0006364 rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01018137001 6954596 6960201 GO:0009611 response to wounding A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism. IEA Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme. IEA GO:0004867 serine-type endopeptidase inhibitor activity GSVIVG01018137001 6954596 6960201 GO:0009611 response to wounding A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01007649001 10859611 10862639 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01007649001 10859611 10862639 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01007649001 10859611 10862639 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01007649001 10859611 10862639 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01024767001 7117548 7118655 GSVIVG01031334001 280442 286055 GSVIVG01005051001 17696019 17698346 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01018558001 13400395 13404929 GSVIVG01002036001 32425556 32428783 GSVIVG01027511001 16088931 16091721 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01027511001 16088931 16091721 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01027511001 16088931 16091721 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01027511001 16088931 16091721 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01016349001 4742981 4744114 GSVIVG01017262001 6043625 6044603 GSVIVG01035511001 1902517 1909484 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01035511001 1902517 1909484 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030126 COPI vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01035511001 1902517 1909484 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01035511001 1902517 1909484 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030126 COPI vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01035511001 1902517 1909484 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035511001 1902517 1909484 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030126 COPI vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035511001 1902517 1909484 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035511001 1902517 1909484 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030126 COPI vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035511001 1902517 1909484 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035511001 1902517 1909484 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030126 COPI vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035511001 1902517 1909484 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035511001 1902517 1909484 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030126 COPI vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018864001 19134301 19137992 GSVIVG01016199001 6704230 6772374 GO:0006904 vesicle docking involved in exocytosis The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis. IEA GSVIVG01016199001 6704230 6772374 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GSVIVG01027954001 10014087 10062107 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027954001 10014087 10062107 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2-phosphoglycolate + H2O = glycolate + phosphate. IEA GO:0008967 phosphoglycolate phosphatase activity GSVIVG01027954001 10014087 10062107 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01029529001 21916350 21918841 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01029529001 21916350 21918841 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01029529001 21916350 21918841 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01029529001 21916350 21918841 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029529001 21916350 21918841 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027725001 7174676 7177875 GSVIVG01007520001 12814374 12826449 GSVIVG01029199001 18615912 18633127 GSVIVG01035041001 1104509 1106640 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01032649001 1817276 1822001 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032649001 1817276 1822001 GO:0019370 leukotriene biosynthetic process The chemical reactions and pathways resulting in the formation of leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032649001 1817276 1822001 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008237 metallopeptidase activity GSVIVG01032649001 1817276 1822001 GO:0019370 leukotriene biosynthetic process The chemical reactions and pathways resulting in the formation of leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid. IEA Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008237 metallopeptidase activity GSVIVG01032649001 1817276 1822001 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01032649001 1817276 1822001 GO:0019370 leukotriene biosynthetic process The chemical reactions and pathways resulting in the formation of leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01021886001 6011968 6013878 GSVIVG01031789001 4368310 4388395 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01031789001 4368310 4388395 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01031789001 4368310 4388395 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01031789001 4368310 4388395 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01031789001 4368310 4388395 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01031789001 4368310 4388395 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031789001 4368310 4388395 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01005751001 21827044 21827908 GSVIVG01027844001 8549658 8553417 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01027844001 8549658 8553417 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01024878001 6301370 6301855 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024878001 6301370 6301855 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024878001 6301370 6301855 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01027710001 13970076 13976998 GSVIVG01024724001 7446084 7447156 GSVIVG01028664001 11839706 11840402 GSVIVG01023497001 10937899 10955728 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01010507001 21183538 21185707 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01010507001 21183538 21185707 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01005921001 859655 862354 GSVIVG01033612001 19309010 19311600 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: 3-alpha(S)-strictosidine = tryptamine + secologanin. IEA GO:0016844 strictosidine synthase activity GSVIVG01035499001 1807544 1816843 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035499001 1807544 1816843 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035499001 1807544 1816843 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035499001 1807544 1816843 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035499001 1807544 1816843 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01035499001 1807544 1816843 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01007692001 10332288 10338338 GSVIVG01002034001 32423637 32424658 GSVIVG01022752001 16133393 16143005 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01000938001 22072445 22074122 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01037658001 6615174 6623463 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. IEA GO:0008137 NADH dehydrogenase (ubiquinone) activity GSVIVG01037658001 6615174 6623463 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01030724001 14579933 14580707 GSVIVG01026670001 4573618 4576653 GSVIVG01013782001 7656708 7665503 GSVIVG01008532001 1048898 1056090 GSVIVG01035266001 11620379 11620570 GSVIVG01021320001 3990588 3995796 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01021320001 3990588 3995796 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01021320001 3990588 3995796 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01021320001 3990588 3995796 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01010426001 20492302 20493162 GSVIVG01007835001 8563255 8583094 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01007835001 8563255 8583094 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01037111001 29067483 29070189 GO:0009765 photosynthesis, light harvesting Absorption and transfer of the energy absorbed from light photons between photosystem reaction centers. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA GSVIVG01037111001 29067483 29070189 GO:0009765 photosynthesis, light harvesting Absorption and transfer of the energy absorbed from light photons between photosystem reaction centers. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01023201001 21196456 21204717 GSVIVG01006574001 26531369 26534143 GSVIVG01016469001 3590205 3601060 GSVIVG01009169001 5683706 5685041 GSVIVG01014468001 4181541 4182679 GSVIVG01021466001 5810542 5811054 GSVIVG01008659001 55861 62009 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01008659001 55861 62009 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01008733001 1535488 1536276 Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01008733001 1535488 1536276 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01038657001 21156215 21158377 GO:0001503 ossification The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance. IEA GSVIVG01038657001 21156215 21158377 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GSVIVG01037895001 6566136 6569256 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01017065001 3903009 3915595 GSVIVG01017297001 6466342 6468810 GSVIVG01018925001 18598157 18604366 GSVIVG01024840001 6513924 6515067 GSVIVG01016854001 1994220 1998581 GSVIVG01016565001 2725961 2727559 GSVIVG01036025001 7425297 7426276 GSVIVG01030884001 18319583 18321146 GSVIVG01025121001 4251511 4259279 GSVIVG01017709001 2824973 2828379 GSVIVG01017397001 7893112 7895197 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01017397001 7893112 7895197 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01015106001 1094197 1097212 GSVIVG01033228001 22381444 22383054 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01033228001 22381444 22383054 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01016417001 4112605 4117850 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01023657001 8612363 8614478 GSVIVG01038603001 21554278 21569250 GSVIVG01022070001 16337943 16345589 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01022070001 16337943 16345589 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01022070001 16337943 16345589 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023193001 21292635 21294012 GSVIVG01007876001 8040092 8045434 GSVIVG01003246001 8291810 8292294 GSVIVG01013301001 1072538 1073733 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01005213001 19258511 19258963 GSVIVG01025574001 13954821 13964238 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01005904001 695182 696499 GSVIVG01031450001 18386516 18387683 GSVIVG01013230001 6504399 6504841 GSVIVG01003722001 7401213 7409072 GSVIVG01019681001 2425763 2427048 GSVIVG01022047001 3797710 3799911 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01022047001 3797710 3799911 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01022047001 3797710 3799911 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01022047001 3797710 3799911 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01022047001 3797710 3799911 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022047001 3797710 3799911 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022047001 3797710 3799911 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01022047001 3797710 3799911 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01018573001 13190473 13212812 GSVIVG01008119001 5631966 5637919 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01036954001 9698361 9706951 GO:0006796 phosphate metabolic process The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01036954001 9698361 9706951 GO:0006796 phosphate metabolic process The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: diphosphate + H2O = 2 phosphate. IEA GO:0004427 inorganic diphosphatase activity GSVIVG01017513001 9757952 9758200 GSVIVG01030948001 19591245 19594622 Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01030948001 19591245 19594622 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030948001 19591245 19594622 Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01030948001 19591245 19594622 Interacting selectively and non-covalently with thiamin pyrophosphate, the diphosphoric ester of thiamin. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases. IEA GO:0030976 thiamin pyrophosphate binding GSVIVG01014268001 2170949 2179821 GSVIVG01032436001 27371460 27397700 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule. IEA GO:0000175 3'-5'-exoribonuclease activity GSVIVG01032436001 27371460 27397700 GO:0006402 mRNA catabolic process The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule. IEA GO:0000175 3'-5'-exoribonuclease activity GSVIVG01032436001 27371460 27397700 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01032436001 27371460 27397700 GO:0006402 mRNA catabolic process The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01032436001 27371460 27397700 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of the reaction: ATP + RNA(n) = diphosphate + RNA(n+1). IEA GO:0004654 polyribonucleotide nucleotidyltransferase activity GSVIVG01032436001 27371460 27397700 GO:0006402 mRNA catabolic process The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of the reaction: ATP + RNA(n) = diphosphate + RNA(n+1). IEA GO:0004654 polyribonucleotide nucleotidyltransferase activity GSVIVG01019609001 1919317 1929177 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01019609001 1919317 1929177 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019609001 1919317 1929177 Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01019609001 1919317 1929177 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01019436001 678147 679886 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019436001 678147 679886 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01019436001 678147 679886 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01021911001 5694165 5695051 GSVIVG01001190001 965314 971757 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001190001 965314 971757 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01001190001 965314 971757 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01001190001 965314 971757 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01001190001 965314 971757 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018927001 18592600 18593688 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018927001 18592600 18593688 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018927001 18592600 18593688 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01018927001 18592600 18593688 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01018927001 18592600 18593688 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01018927001 18592600 18593688 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01001076001 7317082 7319681 GSVIVG01021907001 5779877 5786948 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01021907001 5779877 5786948 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01021907001 5779877 5786948 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01021907001 5779877 5786948 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli. IEA GO:0004707 MAP kinase activity GSVIVG01021907001 5779877 5786948 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01021907001 5779877 5786948 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016758001 1047021 1048056 GSVIVG01012842001 6016844 6019602 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01032967001 24664018 24669912 GO:0000105 histidine biosynthetic process The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. IEA Catalysis of the reaction: 1-(5-phosphoribosyl)-AMP + H2O = 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide. IEA GO:0004635 phosphoribosyl-AMP cyclohydrolase activity GSVIVG01032967001 24664018 24669912 GO:0000105 histidine biosynthetic process The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. IEA Catalysis of the reaction: 5-phosphoribosyl-ATP + H2O = 5-phosphoribosyl-AMP + diphosphate. IEA GO:0004636 phosphoribosyl-ATP diphosphatase activity GSVIVG01026107001 24512440 24512963 GSVIVG01018471001 14603135 14607841 GSVIVG01038019001 16375070 16380407 GSVIVG01017914001 4607597 4617180 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01017914001 4607597 4617180 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01017914001 4607597 4617180 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01017914001 4607597 4617180 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01017914001 4607597 4617180 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017914001 4607597 4617180 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017914001 4607597 4617180 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017914001 4607597 4617180 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025346001 1670958 1688125 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01025346001 1670958 1688125 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01025346001 1670958 1688125 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01025346001 1670958 1688125 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025346001 1670958 1688125 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01000535001 7290490 7296526 GO:0006487 protein amino acid N-linked glycosylation A protein amino acid glycosylation process in which a sugar unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-mannosyl-R = UDP + 4-(N-acetyl-beta-D-glucosaminyl)-beta-D-mannosyl-R. IEA GO:0003830 beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity GSVIVG01000588001 6772858 6781078 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01000588001 6772858 6781078 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01024828001 6575328 6579034 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01012241001 279894 281109 GSVIVG01016476001 3539507 3547141 GSVIVG01030474001 5970028 5975989 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01030474001 5970028 5975989 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01030474001 5970028 5975989 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01030474001 5970028 5975989 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01027016001 18559929 18560865 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027016001 18559929 18560865 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01029421001 17031733 17034212 GO:0015671 oxygen transport The directed movement of oxygen (O2) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01029421001 17031733 17034212 GO:0015671 oxygen transport The directed movement of oxygen (O2) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with oxygen (O2). IEA GO:0019825 oxygen binding GSVIVG01029421001 17031733 17034212 GO:0015671 oxygen transport The directed movement of oxygen (O2) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01018109001 6624065 6632689 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01033962001 16261332 16266123 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01033962001 16261332 16266123 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01028672001 11926605 11932421 GSVIVG01024610001 8438976 8442467 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01002333001 34168471 34168979 GSVIVG01003077001 8336827 8338877 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033824001 17435947 17440650 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Enables the directed movement of acyl groups into, out of, within or between cells. IEA GO:0000036 acyl carrier activity GSVIVG01033824001 17435947 17440650 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. IEA GO:0048037 cofactor binding GSVIVG01024315001 777034 779523 GO:0006559 L-phenylalanine catabolic process The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024315001 777034 779523 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024315001 777034 779523 GO:0006559 L-phenylalanine catabolic process The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of ammonia (NH3) to another substance via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. IEA GO:0016211 ammonia ligase activity GSVIVG01024315001 777034 779523 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of ammonia (NH3) to another substance via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. IEA GO:0016211 ammonia ligase activity GSVIVG01024315001 777034 779523 GO:0006559 L-phenylalanine catabolic process The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate. IEA GO:0016841 ammonia-lyase activity GSVIVG01024315001 777034 779523 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate. IEA GO:0016841 ammonia-lyase activity GSVIVG01034243001 13400541 13408116 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01034243001 13400541 13408116 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01008494001 1351757 1355016 GO:0006097 glyoxylate cycle A modification of the TCA cycle occurring in some plants and microorganisms, in which isocitrate is cleaved to glyoxylate and succinate. Glyoxylate can then react with acetyl-CoA to form malate. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008494001 1351757 1355016 GO:0006097 glyoxylate cycle A modification of the TCA cycle occurring in some plants and microorganisms, in which isocitrate is cleaved to glyoxylate and succinate. Glyoxylate can then react with acetyl-CoA to form malate. IEA Catalysis of the reaction: acetyl-CoA + H2O + glyoxylate = L-malate + CoA. IEA GO:0004474 malate synthase activity GSVIVG01036998001 9111919 9120041 GSVIVG01029113001 19509439 19545517 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01029113001 19509439 19545517 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01029113001 19509439 19545517 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01029113001 19509439 19545517 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01029113001 19509439 19545517 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01029113001 19509439 19545517 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01029113001 19509439 19545517 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01029113001 19509439 19545517 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01029113001 19509439 19545517 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate. IEA GO:0019001 guanyl nucleotide binding GSVIVG01029113001 19509439 19545517 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate. IEA GO:0019001 guanyl nucleotide binding GSVIVG01029113001 19509439 19545517 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate. IEA GO:0019001 guanyl nucleotide binding GSVIVG01029113001 19509439 19545517 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate. IEA GO:0019001 guanyl nucleotide binding GSVIVG01003978001 26436070 26436859 Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01003978001 26436070 26436859 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01027950001 9935078 9953608 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01027950001 9935078 9953608 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01027950001 9935078 9953608 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01027950001 9935078 9953608 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01038647001 21228111 21238026 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01038647001 21228111 21238026 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01000925001 21945723 21956866 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01000925001 21945723 21956866 Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. IEA GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GSVIVG01016024001 17503162 17513980 GSVIVG01014515001 4714503 4715407 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014515001 4714503 4715407 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014515001 4714503 4715407 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014515001 4714503 4715407 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009979001 12997417 13013502 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01009979001 12997417 13013502 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01009979001 12997417 13013502 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01009979001 12997417 13013502 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01005732001 13935232 13937980 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01019801001 3445601 3447792 GSVIVG01013532001 2432873 2443345 GO:0032312 regulation of ARF GTPase activity Any process that modulates the activity of the GTPase ARF. IEA Increases the rate of GTP hydrolysis by the GTPase ARF. IEA GO:0008060 ARF GTPase activator activity GSVIVG01013532001 2432873 2443345 GO:0032312 regulation of ARF GTPase activity Any process that modulates the activity of the GTPase ARF. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008187001 4885701 4888937 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01008187001 4885701 4888937 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01038279001 24928355 24933739 GSVIVG01018843001 19373393 19378100 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01018843001 19373393 19378100 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds. IEA GO:0015035 protein disulfide oxidoreductase activity GSVIVG01033858001 17201882 17202192 GSVIVG01027800001 7893718 7899140 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01027870001 8803756 8806188 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01027870001 8803756 8806188 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01014750001 9194802 9198616 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014750001 9194802 9198616 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014750001 9194802 9198616 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014750001 9194802 9198616 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014750001 9194802 9198616 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014750001 9194802 9198616 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014750001 9194802 9198616 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014750001 9194802 9198616 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014750001 9194802 9198616 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014750001 9194802 9198616 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003887001 13164664 13165564 GSVIVG01025004001 5357060 5358214 GSVIVG01021736001 10325986 10327774 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021736001 10325986 10327774 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021736001 10325986 10327774 Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01024299001 649922 652537 GO:0006559 L-phenylalanine catabolic process The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024299001 649922 652537 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024299001 649922 652537 GO:0006559 L-phenylalanine catabolic process The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of ammonia (NH3) to another substance via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. IEA GO:0016211 ammonia ligase activity GSVIVG01024299001 649922 652537 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of ammonia (NH3) to another substance via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. IEA GO:0016211 ammonia ligase activity GSVIVG01024299001 649922 652537 GO:0006559 L-phenylalanine catabolic process The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate. IEA GO:0016841 ammonia-lyase activity GSVIVG01024299001 649922 652537 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate. IEA GO:0016841 ammonia-lyase activity GSVIVG01012359001 1282784 1289702 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01012359001 1282784 1289702 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01012359001 1282784 1289702 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01012359001 1282784 1289702 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01012359001 1282784 1289702 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01012359001 1282784 1289702 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01012359001 1282784 1289702 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01012359001 1282784 1289702 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01009028001 4391879 4398813 GSVIVG01020524001 4845865 4847466 GSVIVG01000121001 15423553 15424064 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01000121001 15423553 15424064 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01000121001 15423553 15424064 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015934 large ribosomal subunit The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01010721001 12750778 12790983 GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01010721001 12750778 12790983 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01009564001 9445759 9458200 GSVIVG01003470001 10553765 10556235 GSVIVG01023535001 10097731 10112715 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01020548001 4594677 4607983 GO:0006075 1,3-beta-glucan biosynthetic process The chemical reactions and pathways resulting in the formation of beta-1,3 glucans, compounds composed of glucose residues linked by 1,3-beta-D-glucosidic bonds. IEA GO:0000148 1,3-beta-glucan synthase complex A protein complex that catalyzes the transfer of a glucose moiety from UDP-glucose to a 1,3-beta-D-glucan chain. IEA Catalysis of the reaction: UDP-glucose + 1,3-beta-D-glucosyl(n) = UDP + 1,3-beta-D-glucosyl(n+1). IEA GO:0003843 1,3-beta-glucan synthase activity GSVIVG01020548001 4594677 4607983 GO:0006075 1,3-beta-glucan biosynthetic process The chemical reactions and pathways resulting in the formation of beta-1,3 glucans, compounds composed of glucose residues linked by 1,3-beta-D-glucosidic bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: UDP-glucose + 1,3-beta-D-glucosyl(n) = UDP + 1,3-beta-D-glucosyl(n+1). IEA GO:0003843 1,3-beta-glucan synthase activity GSVIVG01024661001 7975616 7976912 GSVIVG01032472001 27737288 27737584 GSVIVG01027569001 15481573 15486589 GSVIVG01005520001 40531244 40532544 GSVIVG01035470001 1524969 1528585 GSVIVG01004700001 15284209 15286387 GSVIVG01038353001 13418372 13419580 GSVIVG01002633001 35538830 35547034 GSVIVG01030443001 5589738 5591768 GSVIVG01019009001 17832554 17863982 GO:0006351 transcription, DNA-dependent The cellular synthesis of RNA on a template of DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019009001 17832554 17863982 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019009001 17832554 17863982 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019009001 17832554 17863982 GO:0006351 transcription, DNA-dependent The cellular synthesis of RNA on a template of DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01019009001 17832554 17863982 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01019009001 17832554 17863982 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01019009001 17832554 17863982 GO:0006351 transcription, DNA-dependent The cellular synthesis of RNA on a template of DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01019009001 17832554 17863982 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01019009001 17832554 17863982 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01019009001 17832554 17863982 GO:0006351 transcription, DNA-dependent The cellular synthesis of RNA on a template of DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01019009001 17832554 17863982 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01019009001 17832554 17863982 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01015140001 1327977 1330009 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015140001 1327977 1330009 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the ligation of ammonia (NH3) to another substance via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. IEA GO:0016211 ammonia ligase activity GSVIVG01004517001 38986774 38992091 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01005963001 22993794 22994797 GSVIVG01026450001 23417241 23454255 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01026450001 23417241 23454255 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01026450001 23417241 23454255 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01026450001 23417241 23454255 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014492001 4430250 4433793 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014492001 4430250 4433793 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014492001 4430250 4433793 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014492001 4430250 4433793 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014492001 4430250 4433793 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014492001 4430250 4433793 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014492001 4430250 4433793 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014492001 4430250 4433793 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013364001 945271 948428 GSVIVG01009938001 12620619 12628019 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01009938001 12620619 12628019 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028671001 11922098 11926081 GSVIVG01030141001 10196870 10201648 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA Catalysis of the reaction: ATP + alpha-D-glucose 1-phosphate = diphosphate + ADP-glucose. IEA GO:0008878 glucose-1-phosphate adenylyltransferase activity GSVIVG01030141001 10196870 10201648 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: ATP + alpha-D-glucose 1-phosphate = diphosphate + ADP-glucose. IEA GO:0008878 glucose-1-phosphate adenylyltransferase activity GSVIVG01030141001 10196870 10201648 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA Catalysis of the transfer of a nucleotidyl group to a reactant. IEA GO:0016779 nucleotidyltransferase activity GSVIVG01030141001 10196870 10201648 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nucleotidyl group to a reactant. IEA GO:0016779 nucleotidyltransferase activity GSVIVG01021406001 5026588 5028897 GO:0009765 photosynthesis, light harvesting Absorption and transfer of the energy absorbed from light photons between photosystem reaction centers. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01031955001 5675383 5686006 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005798 Golgi-associated vesicle Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01031955001 5675383 5686006 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01031955001 5675383 5686006 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030126 COPI vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01031955001 5675383 5686006 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0005798 Golgi-associated vesicle Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01031955001 5675383 5686006 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01031955001 5675383 5686006 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030126 COPI vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01031955001 5675383 5686006 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005798 Golgi-associated vesicle Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031955001 5675383 5686006 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031955001 5675383 5686006 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030126 COPI vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031955001 5675383 5686006 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0005798 Golgi-associated vesicle Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031955001 5675383 5686006 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031955001 5675383 5686006 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030126 COPI vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031955001 5675383 5686006 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005798 Golgi-associated vesicle Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031955001 5675383 5686006 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031955001 5675383 5686006 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030126 COPI vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031955001 5675383 5686006 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0005798 Golgi-associated vesicle Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031955001 5675383 5686006 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031955001 5675383 5686006 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030126 COPI vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035186001 10076961 10087441 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01035186001 10076961 10087441 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01035186001 10076961 10087441 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01035186001 10076961 10087441 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012878001 6464745 6465020 GSVIVG01031845001 4827172 4848481 GO:0007154 cell communication Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031845001 4827172 4848481 GO:0007154 cell communication Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. IEA Interacting selectively and non-covalently with any inositol-containing glycerophospholipid. Phosphatidylinositol (PtdIns) and its phosphorylated derivatives are collectively referred to as phosphoinositides (PIs). IEA GO:0035091 phosphoinositide binding GSVIVG01016442001 3879632 3883469 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01016442001 3879632 3883469 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01016442001 3879632 3883469 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01016442001 3879632 3883469 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01001586001 5573397 5574802 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036523001 23043321 23046274 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01027059001 18267121 18267274 GSVIVG01037214001 27919150 27920966 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01037214001 27919150 27920966 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01037214001 27919150 27920966 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01015398001 3271417 3276160 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01015398001 3271417 3276160 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01015398001 3271417 3276160 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01015398001 3271417 3276160 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01015398001 3271417 3276160 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01015398001 3271417 3276160 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01015398001 3271417 3276160 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01015398001 3271417 3276160 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01015398001 3271417 3276160 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01015398001 3271417 3276160 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01015398001 3271417 3276160 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01015398001 3271417 3276160 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01015398001 3271417 3276160 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01015398001 3271417 3276160 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01015398001 3271417 3276160 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01008538001 1010133 1017233 GSVIVG01017755001 3167517 3178049 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01017755001 3167517 3178049 GO:0006419 alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01017755001 3167517 3178049 GO:0043039 tRNA aminoacylation The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01017755001 3167517 3178049 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01017755001 3167517 3178049 GO:0006419 alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01017755001 3167517 3178049 GO:0043039 tRNA aminoacylation The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01017755001 3167517 3178049 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala). IEA GO:0004813 alanine-tRNA ligase activity GSVIVG01017755001 3167517 3178049 GO:0006419 alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala). IEA GO:0004813 alanine-tRNA ligase activity GSVIVG01017755001 3167517 3178049 GO:0043039 tRNA aminoacylation The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala). IEA GO:0004813 alanine-tRNA ligase activity GSVIVG01017755001 3167517 3178049 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017755001 3167517 3178049 GO:0006419 alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017755001 3167517 3178049 GO:0043039 tRNA aminoacylation The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017755001 3167517 3178049 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances via a carbon-oxygen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate, to form aminoacyl-tRNA or a related compound. IEA GO:0016876 ligase activity, forming aminoacyl-tRNA and related compounds GSVIVG01017755001 3167517 3178049 GO:0006419 alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances via a carbon-oxygen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate, to form aminoacyl-tRNA or a related compound. IEA GO:0016876 ligase activity, forming aminoacyl-tRNA and related compounds GSVIVG01017755001 3167517 3178049 GO:0043039 tRNA aminoacylation The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances via a carbon-oxygen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate, to form aminoacyl-tRNA or a related compound. IEA GO:0016876 ligase activity, forming aminoacyl-tRNA and related compounds GSVIVG01011395001 29309226 29314642 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01011395001 29309226 29314642 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01011395001 29309226 29314642 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006782001 273777 278538 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA GSVIVG01015772001 17278267 17287864 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor). IEA GO:0004659 prenyltransferase activity GSVIVG01015772001 17278267 17287864 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor). IEA GO:0004659 prenyltransferase activity GSVIVG01015772001 17278267 17287864 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01015772001 17278267 17287864 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01030589001 6947569 6952846 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01030589001 6947569 6952846 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01030589001 6947569 6952846 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01030589001 6947569 6952846 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01008490001 1396401 1415227 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01001603001 18330212 18334024 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01001603001 18330212 18334024 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01001603001 18330212 18334024 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01001603001 18330212 18334024 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01001603001 18330212 18334024 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001603001 18330212 18334024 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01020740001 2446160 2448416 GSVIVG01017407001 8083126 8101856 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01010429001 20529405 20530313 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01010429001 20529405 20530313 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01004031001 14341509 14342500 GSVIVG01026528001 22252566 22254371 GSVIVG01005074001 17999913 18002879 GSVIVG01007479001 32177030 32183199 GSVIVG01001140001 22961219 22972983 GSVIVG01018715001 10691873 10719210 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01018715001 10691873 10719210 GO:0051276 chromosome organization A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01018715001 10691873 10719210 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018715001 10691873 10719210 GO:0051276 chromosome organization A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018715001 10691873 10719210 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018715001 10691873 10719210 GO:0051276 chromosome organization A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018715001 10691873 10719210 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01018715001 10691873 10719210 GO:0051276 chromosome organization A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01010600001 16145022 16162952 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01010600001 16145022 16162952 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01010600001 16145022 16162952 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01010600001 16145022 16162952 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01010600001 16145022 16162952 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01010600001 16145022 16162952 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01010600001 16145022 16162952 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01010600001 16145022 16162952 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01025929001 27135201 27138565 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025929001 27135201 27138565 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0010181 FMN binding GSVIVG01025929001 27135201 27138565 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01028704001 19636837 19641201 GSVIVG01017246001 5874911 5882490 GSVIVG01012941001 14000594 14084302 GO:0006071 glycerol metabolic process The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + glycerone = ADP + glycerone phosphate. IEA GO:0004371 glycerone kinase activity GSVIVG01012941001 14000594 14084302 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + glycerone = ADP + glycerone phosphate. IEA GO:0004371 glycerone kinase activity GSVIVG01012941001 14000594 14084302 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + glycerone = ADP + glycerone phosphate. IEA GO:0004371 glycerone kinase activity GSVIVG01012941001 14000594 14084302 GO:0006071 glycerol metabolic process The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012941001 14000594 14084302 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012941001 14000594 14084302 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012941001 14000594 14084302 GO:0006071 glycerol metabolic process The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01012941001 14000594 14084302 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01012941001 14000594 14084302 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01033199001 9458118 9459081 GSVIVG01030174001 10843756 10846082 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01030174001 10843756 10846082 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01037975001 11930376 11932348 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01037975001 11930376 11932348 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01037975001 11930376 11932348 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01037975001 11930376 11932348 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01002894001 37070241 37072198 GSVIVG01032013001 23566199 23569939 GSVIVG01031278001 645197 647269 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01003214001 13949445 13973750 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01003214001 13949445 13973750 GO:0009966 regulation of signal transduction Any process that modulates the frequency, rate or extent of signal transduction. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01003214001 13949445 13973750 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01003214001 13949445 13973750 GO:0009966 regulation of signal transduction Any process that modulates the frequency, rate or extent of signal transduction. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01003214001 13949445 13973750 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01003214001 13949445 13973750 GO:0009966 regulation of signal transduction Any process that modulates the frequency, rate or extent of signal transduction. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01003214001 13949445 13973750 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003214001 13949445 13973750 GO:0009966 regulation of signal transduction Any process that modulates the frequency, rate or extent of signal transduction. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018154001 13812762 13829500 Catalysis of the transfer of a nucleotidyl group to a reactant. IEA GO:0016779 nucleotidyltransferase activity GSVIVG01016118001 19317143 19330227 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01016118001 19317143 19330227 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01016118001 19317143 19330227 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01016118001 19317143 19330227 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01008934001 3564130 3567538 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01003488001 10683980 10684735 GSVIVG01014509001 4653435 4658268 GSVIVG01024779001 7015915 7016088 GSVIVG01031796001 4433890 4442649 Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01031796001 4433890 4442649 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01025537001 14214160 14226917 GO:0006464 protein modification process The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025537001 14214160 14226917 GO:0006464 protein modification process The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. IEA GO:0016881 acid-amino acid ligase activity GSVIVG01015082001 905952 912492 GO:0006464 protein modification process The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). IEA Catalysis of the reaction: ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate. IEA GO:0004835 tubulin-tyrosine ligase activity GSVIVG01007042001 29841760 29849049 GSVIVG01028326001 6177974 6190004 GSVIVG01002734001 36267022 36278604 GSVIVG01029726001 13787195 13787504 GSVIVG01036201001 9102878 9103504 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01036201001 9102878 9103504 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01013554001 20732551 20735315 GSVIVG01007669001 10669113 10682432 GO:0009308 amine metabolic process The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01007669001 10669113 10682432 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01007669001 10669113 10682432 GO:0009308 amine metabolic process The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01007669001 10669113 10682432 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01007669001 10669113 10682432 GO:0009308 amine metabolic process The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. IEA Catalysis of the reaction: R-CH2-NH2 + H2O + O2 = R-CHO + NH3 + H2O2. IEA GO:0008131 amine oxidase activity GSVIVG01007669001 10669113 10682432 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: R-CH2-NH2 + H2O + O2 = R-CHO + NH3 + H2O2. IEA GO:0008131 amine oxidase activity GSVIVG01007669001 10669113 10682432 GO:0009308 amine metabolic process The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. IEA Interacting selectively and non-covalently with a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds. IEA GO:0048038 quinone binding GSVIVG01007669001 10669113 10682432 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds. IEA GO:0048038 quinone binding GSVIVG01024544001 8989627 8995587 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01024544001 8989627 8995587 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024544001 8989627 8995587 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01024544001 8989627 8995587 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01024544001 8989627 8995587 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01019872001 4105426 4105566 GSVIVG01034814001 21988536 21991912 GSVIVG01011259001 10207403 10208656 Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate. IEA GO:0008146 sulfotransferase activity GSVIVG01030672001 13279934 13281307 GSVIVG01000720001 165517 166674 The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01031170001 1541576 1545075 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01027467001 16503725 16505772 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01018537001 13667253 13670907 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01018537001 13667253 13670907 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01022213001 17541013 17544022 GSVIVG01037923001 6313287 6314625 GSVIVG01027891001 9110996 9114911 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01027891001 9110996 9114911 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01021995001 4574739 4581966 GSVIVG01000035001 2954033 2962085 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000035001 2954033 2962085 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01001821001 26092717 26096789 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01001821001 26092717 26096789 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01025357001 1568993 1572434 GSVIVG01011894001 3223092 3227774 GSVIVG01010340001 19621573 19632678 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01010340001 19621573 19632678 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01010340001 19621573 19632678 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01010340001 19621573 19632678 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01006393001 25595584 25595978 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01006393001 25595584 25595978 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01013646001 2128319 2149798 GSVIVG01036717001 23388000 23390312 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01031112001 2059336 2063219 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01036118001 20506693 20507961 GSVIVG01028972001 16992466 16995367 GSVIVG01026147001 12993694 12993789 GSVIVG01009750001 10968173 10971522 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01009750001 10968173 10971522 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01009750001 10968173 10971522 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01009750001 10968173 10971522 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01009750001 10968173 10971522 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01009750001 10968173 10971522 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01018669001 11422046 11423718 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01018669001 11422046 11423718 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024835001 6537163 6542533 GSVIVG01038630001 21341512 21343257 GO:0016068 type I hypersensitivity An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells or basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01038630001 21341512 21343257 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01038630001 21341512 21343257 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01034910001 32006 36655 GSVIVG01032061001 23114526 23117627 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01032061001 23114526 23117627 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01001745001 721632 722114 GSVIVG01010238001 18082562 18106134 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01028268001 5043747 5044351 GSVIVG01020655001 3379784 3383297 GSVIVG01035322001 458259 466276 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005945 6-phosphofructokinase complex A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known. IEA Catalysis of the reaction: ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate. IEA GO:0003872 6-phosphofructokinase activity GSVIVG01035322001 458259 466276 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005945 6-phosphofructokinase complex A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015562001 4943429 4944970 Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01015562001 4943429 4944970 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01017758001 3183731 3190850 GSVIVG01028683001 12046991 12050079 GSVIVG01014078001 192853 198053 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01014078001 192853 198053 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01007271001 1190020 1198807 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0000159 protein phosphatase type 2A complex A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit. IEA Modulation of the activity of the enzyme protein phosphatase type 2A. IEA GO:0008601 protein phosphatase type 2A regulator activity GSVIVG01019196001 3692666 3710910 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01011303001 8191592 8193573 GSVIVG01035699001 3427250 3438858 GSVIVG01000132001 15540264 15554852 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01000132001 15540264 15554852 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01000132001 15540264 15554852 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01000132001 15540264 15554852 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01000132001 15540264 15554852 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014715001 8932025 8934203 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01014715001 8932025 8934203 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA A ligand-dependent receptor found in the nucleus of the cell. IEA GO:0004879 ligand-dependent nuclear receptor activity GSVIVG01001810001 26002558 26007200 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001810001 26002558 26007200 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001810001 26002558 26007200 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: D-ribulose 5-phosphate = D-xylulose 5-phosphate. IEA GO:0004750 ribulose-phosphate 3-epimerase activity GSVIVG01001810001 26002558 26007200 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: D-ribulose 5-phosphate = D-xylulose 5-phosphate. IEA GO:0004750 ribulose-phosphate 3-epimerase activity GSVIVG01022009001 4356940 4369523 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01000659001 20510337 20514702 GSVIVG01029650001 20199168 20203653 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01028182001 4464037 4466497 GSVIVG01021700001 9750970 9753190 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with manganese (Mn) ions. IEA GO:0030145 manganese ion binding GSVIVG01021700001 9750970 9753190 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Functions in the storage of nutritious substrates. IEA GO:0045735 nutrient reservoir activity GSVIVG01036062001 21224750 21225736 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01017689001 2667668 2671970 GO:0015969 guanosine tetraphosphate metabolic process The chemical reactions and pathways involving guanine tetraphosphate (5'-ppGpp-3'), a derivative of guanine riboside with four phosphates. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01000099001 3525107 3528061 GSVIVG01026811001 7647421 7648971 GSVIVG01029331001 14475340 14480298 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GSVIVG01036708001 23495533 23508846 GSVIVG01013409001 642569 645549 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GSVIVG01033924001 16686637 16690462 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01033924001 16686637 16690462 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01029194001 18708816 18714223 GO:0006820 anion transport The directed movement of anions, atoms or small molecules with a net negative charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005741 mitochondrial outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope. IEA Catalysis of the transmembrane transfer of an anion by a voltage-gated channel. An anion is a negatively charged ion. IEA GO:0008308 voltage-gated anion channel activity GSVIVG01029194001 18708816 18714223 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005741 mitochondrial outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope. IEA Catalysis of the transmembrane transfer of an anion by a voltage-gated channel. An anion is a negatively charged ion. IEA GO:0008308 voltage-gated anion channel activity GSVIVG01017714001 2859892 2863796 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01017714001 2859892 2863796 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01017714001 2859892 2863796 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01017714001 2859892 2863796 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01038315001 12640641 12640853 GSVIVG01027717001 7052205 7076037 GSVIVG01031900001 5258910 5261637 GO:0015671 oxygen transport The directed movement of oxygen (O2) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01031900001 5258910 5261637 GO:0015671 oxygen transport The directed movement of oxygen (O2) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with oxygen (O2). IEA GO:0019825 oxygen binding GSVIVG01031900001 5258910 5261637 GO:0015671 oxygen transport The directed movement of oxygen (O2) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01012464001 1222899 1249898 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function that links a sequence-specific transcription factor to the core RNA polymerase II complex but does not bind DNA itself. IEA GO:0003712 transcription cofactor activity GSVIVG01012464001 1222899 1249898 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023723001 10114262 10128936 GO:0006506 GPI anchor biosynthetic process The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol moiety is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate moiety, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage. IEA GO:0031227 intrinsic to endoplasmic reticulum membrane Located in the endoplasmic reticulum membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01025841001 11320916 11323320 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01025841001 11320916 11323320 GO:0015995 chlorophyll biosynthetic process The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01025841001 11320916 11323320 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01025841001 11320916 11323320 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025841001 11320916 11323320 GO:0015995 chlorophyll biosynthetic process The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025841001 11320916 11323320 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025841001 11320916 11323320 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01025841001 11320916 11323320 GO:0015995 chlorophyll biosynthetic process The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01025841001 11320916 11323320 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01025841001 11320916 11323320 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01025841001 11320916 11323320 GO:0015995 chlorophyll biosynthetic process The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01025841001 11320916 11323320 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01025841001 11320916 11323320 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA Catalysis of the reaction: magnesium-protoporphyrin IX 13-monomethyl ester + 3 NADPH + 3 H+ + 3 O2 = divinylprotochlorophyllide + 3 NADP+ + 5 H2O. IEA GO:0048529 magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase activity GSVIVG01025841001 11320916 11323320 GO:0015995 chlorophyll biosynthetic process The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors. IEA Catalysis of the reaction: magnesium-protoporphyrin IX 13-monomethyl ester + 3 NADPH + 3 H+ + 3 O2 = divinylprotochlorophyllide + 3 NADP+ + 5 H2O. IEA GO:0048529 magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase activity GSVIVG01025841001 11320916 11323320 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: magnesium-protoporphyrin IX 13-monomethyl ester + 3 NADPH + 3 H+ + 3 O2 = divinylprotochlorophyllide + 3 NADP+ + 5 H2O. IEA GO:0048529 magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase activity GSVIVG01017980001 5261959 5263005 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01017980001 5261959 5263005 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01022530001 4430524 4436947 GO:0005986 sucrose biosynthetic process The chemical reactions and pathways resulting in the formation of sucrose, the disaccharide fructofuranosyl-glucopyranoside. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01022530001 4430524 4436947 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01022530001 4430524 4436947 GO:0005986 sucrose biosynthetic process The chemical reactions and pathways resulting in the formation of sucrose, the disaccharide fructofuranosyl-glucopyranoside. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01022530001 4430524 4436947 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01022530001 4430524 4436947 GO:0005986 sucrose biosynthetic process The chemical reactions and pathways resulting in the formation of sucrose, the disaccharide fructofuranosyl-glucopyranoside. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. IEA GO:0016791 phosphatase activity GSVIVG01022530001 4430524 4436947 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. IEA GO:0016791 phosphatase activity GSVIVG01022530001 4430524 4436947 GO:0005986 sucrose biosynthetic process The chemical reactions and pathways resulting in the formation of sucrose, the disaccharide fructofuranosyl-glucopyranoside. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: sucrose 6F-phosphate + H2O = sucrose + phosphate. IEA GO:0050307 sucrose-phosphatase activity GSVIVG01022530001 4430524 4436947 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: sucrose 6F-phosphate + H2O = sucrose + phosphate. IEA GO:0050307 sucrose-phosphatase activity GSVIVG01015039001 666331 667415 GSVIVG01009633001 10068356 10074521 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01009633001 10068356 10074521 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01009633001 10068356 10074521 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01009633001 10068356 10074521 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01009633001 10068356 10074521 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01009633001 10068356 10074521 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01023577001 9397552 9398059 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032176001 21804005 21805560 GSVIVG01022126001 16779987 16789641 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01022126001 16779987 16789641 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01014596001 5439380 5442644 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01014596001 5439380 5442644 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01014596001 5439380 5442644 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014596001 5439380 5442644 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014596001 5439380 5442644 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01014596001 5439380 5442644 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01024709001 7573772 7575277 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01024709001 7573772 7575277 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01024709001 7573772 7575277 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031462001 18276926 18280918 GO:0006801 superoxide metabolic process The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + H2O2. IEA GO:0004784 superoxide dismutase activity GSVIVG01031462001 18276926 18280918 GO:0006801 superoxide metabolic process The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + H2O2. IEA GO:0004784 superoxide dismutase activity GSVIVG01031462001 18276926 18280918 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + H2O2. IEA GO:0004784 superoxide dismutase activity GSVIVG01031462001 18276926 18280918 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + H2O2. IEA GO:0004784 superoxide dismutase activity GSVIVG01031462001 18276926 18280918 GO:0006801 superoxide metabolic process The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01031462001 18276926 18280918 GO:0006801 superoxide metabolic process The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01031462001 18276926 18280918 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01031462001 18276926 18280918 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01031462001 18276926 18280918 GO:0006801 superoxide metabolic process The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01031462001 18276926 18280918 GO:0006801 superoxide metabolic process The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01031462001 18276926 18280918 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01031462001 18276926 18280918 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01031462001 18276926 18280918 GO:0006801 superoxide metabolic process The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage. IEA GO:0016209 antioxidant activity GSVIVG01031462001 18276926 18280918 GO:0006801 superoxide metabolic process The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage. IEA GO:0016209 antioxidant activity GSVIVG01031462001 18276926 18280918 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage. IEA GO:0016209 antioxidant activity GSVIVG01031462001 18276926 18280918 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage. IEA GO:0016209 antioxidant activity GSVIVG01031462001 18276926 18280918 GO:0006801 superoxide metabolic process The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031462001 18276926 18280918 GO:0006801 superoxide metabolic process The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031462001 18276926 18280918 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031462001 18276926 18280918 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031462001 18276926 18280918 GO:0006801 superoxide metabolic process The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01031462001 18276926 18280918 GO:0006801 superoxide metabolic process The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01031462001 18276926 18280918 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01031462001 18276926 18280918 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01031058001 21558798 21560892 GSVIVG01011825001 3826036 3828965 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01011825001 3826036 3828965 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01011825001 3826036 3828965 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01011825001 3826036 3828965 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01011825001 3826036 3828965 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01011825001 3826036 3828965 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01031649001 19600419 19604497 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031649001 19600419 19604497 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031649001 19600419 19604497 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008828001 2519475 2521072 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01001380001 24107258 24108847 GSVIVG01003926001 13856059 13856265 GSVIVG01037929001 11069248 11073222 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01037929001 11069248 11073222 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01034495001 20356682 20367644 GO:0005923 tight junction An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01022204001 17437769 17441237 GSVIVG01003390001 9826030 9833560 GSVIVG01016394001 4240678 4246840 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01015461001 3887993 3897672 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01015461001 3887993 3897672 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015461001 3887993 3897672 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01015461001 3887993 3897672 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01030300001 9270702 9271574 GSVIVG01036089001 20803183 20813031 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01036089001 20803183 20813031 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01036089001 20803183 20813031 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01036089001 20803183 20813031 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01036089001 20803183 20813031 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01036089001 20803183 20813031 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01036089001 20803183 20813031 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01036089001 20803183 20813031 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01030275001 9628266 9633445 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01030275001 9628266 9633445 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01030275001 9628266 9633445 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01030275001 9628266 9633445 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033649001 18925170 18940308 GSVIVG01021164001 2087171 2091080 GO:0009405 pathogenesis The set of specific processes that generate the ability of an organism to cause disease in another. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01021164001 2087171 2091080 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01023935001 2346118 2352506 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01017169001 4901145 4908637 GO:0006506 GPI anchor biosynthetic process The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol moiety is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate moiety, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01017169001 4901145 4908637 GO:0006506 GPI anchor biosynthetic process The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol moiety is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate moiety, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage. IEA GO:0005789 endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01017169001 4901145 4908637 GO:0006506 GPI anchor biosynthetic process The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol moiety is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate moiety, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01009062001 4612777 4631139 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01033589001 19486629 19487294 GSVIVG01021686001 9476332 9511615 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01021686001 9476332 9511615 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01021686001 9476332 9511615 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01021686001 9476332 9511615 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01021686001 9476332 9511615 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013932001 6988584 6988861 GSVIVG01011696001 5061081 5062107 GSVIVG01018782001 19923029 19924620 GSVIVG01035402001 1036988 1039484 GO:0006829 zinc ion transport The directed movement of zinc (Zn) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. IEA GO:0005385 zinc ion transmembrane transporter activity GSVIVG01035402001 1036988 1039484 GO:0006829 zinc ion transport The directed movement of zinc (Zn) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. IEA GO:0005385 zinc ion transmembrane transporter activity GSVIVG01035402001 1036988 1039484 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. IEA GO:0005385 zinc ion transmembrane transporter activity GSVIVG01035402001 1036988 1039484 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. IEA GO:0005385 zinc ion transmembrane transporter activity GSVIVG01035402001 1036988 1039484 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. IEA GO:0005385 zinc ion transmembrane transporter activity GSVIVG01035402001 1036988 1039484 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. IEA GO:0005385 zinc ion transmembrane transporter activity GSVIVG01035402001 1036988 1039484 GO:0006829 zinc ion transport The directed movement of zinc (Zn) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01035402001 1036988 1039484 GO:0006829 zinc ion transport The directed movement of zinc (Zn) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01035402001 1036988 1039484 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01035402001 1036988 1039484 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01035402001 1036988 1039484 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01035402001 1036988 1039484 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01021802001 7174322 7174970 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021802001 7174322 7174970 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021802001 7174322 7174970 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021802001 7174322 7174970 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021802001 7174322 7174970 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01021802001 7174322 7174970 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01018974001 18201454 18202166 GSVIVG01026045001 25338627 25339264 GO:0015671 oxygen transport The directed movement of oxygen (O2) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01026045001 25338627 25339264 GO:0015671 oxygen transport The directed movement of oxygen (O2) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with oxygen (O2). IEA GO:0019825 oxygen binding GSVIVG01026045001 25338627 25339264 GO:0015671 oxygen transport The directed movement of oxygen (O2) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01021990001 4682542 4683548 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01021990001 4682542 4683548 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01021990001 4682542 4683548 GO:0006431 methionyl-tRNA aminoacylation The process of coupling methionine to methionyl-tRNA, catalyzed by methionyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01021990001 4682542 4683548 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01021990001 4682542 4683548 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01021990001 4682542 4683548 GO:0006431 methionyl-tRNA aminoacylation The process of coupling methionine to methionyl-tRNA, catalyzed by methionyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01021990001 4682542 4683548 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met). IEA GO:0004825 methionine-tRNA ligase activity GSVIVG01021990001 4682542 4683548 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met). IEA GO:0004825 methionine-tRNA ligase activity GSVIVG01021990001 4682542 4683548 GO:0006431 methionyl-tRNA aminoacylation The process of coupling methionine to methionyl-tRNA, catalyzed by methionyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met). IEA GO:0004825 methionine-tRNA ligase activity GSVIVG01021990001 4682542 4683548 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021990001 4682542 4683548 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021990001 4682542 4683548 GO:0006431 methionyl-tRNA aminoacylation The process of coupling methionine to methionyl-tRNA, catalyzed by methionyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010018001 13494965 13497893 GSVIVG01024825001 6589718 6591552 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01024825001 6589718 6591552 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01024825001 6589718 6591552 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01024825001 6589718 6591552 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01024825001 6589718 6591552 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01024825001 6589718 6591552 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01024825001 6589718 6591552 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01024825001 6589718 6591552 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01024825001 6589718 6591552 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01024825001 6589718 6591552 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01024825001 6589718 6591552 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01024825001 6589718 6591552 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01024825001 6589718 6591552 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01024825001 6589718 6591552 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01024825001 6589718 6591552 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01024825001 6589718 6591552 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01024825001 6589718 6591552 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01024825001 6589718 6591552 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01003421001 14850173 14852448 Interacting selectively and non-covalently with a specific domain of a protein. IEA GO:0019904 protein domain specific binding GSVIVG01037857001 7065044 7065631 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01028412001 7316929 7319461 GSVIVG01016628001 2353916 2354982 GSVIVG01013780001 7676013 7685109 GSVIVG01023563001 9581758 9587255 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023563001 9581758 9587255 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023563001 9581758 9587255 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023563001 9581758 9587255 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023563001 9581758 9587255 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023563001 9581758 9587255 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023563001 9581758 9587255 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01023563001 9581758 9587255 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01026146001 12965839 12972578 GSVIVG01011742001 4661913 4662737 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024926001 5967219 5968466 GO:0006481 C-terminal protein amino acid methylation The methylation of the C-terminal amino acid of a protein. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester. IEA GO:0004671 protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity GSVIVG01006980001 29563113 29571555 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01006980001 29563113 29571555 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01006980001 29563113 29571555 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01006980001 29563113 29571555 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01006980001 29563113 29571555 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01006980001 29563113 29571555 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01006980001 29563113 29571555 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006980001 29563113 29571555 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010045001 13805368 13806761 GSVIVG01004465001 38697362 38703055 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01004465001 38697362 38703055 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01004465001 38697362 38703055 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01004465001 38697362 38703055 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01004465001 38697362 38703055 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036771001 22763855 22769558 GSVIVG01027509001 16111659 16122638 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01034926001 168302 170427 GSVIVG01026925001 19352294 19355234 GSVIVG01033299001 21712009 21715096 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01033299001 21712009 21715096 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01033299001 21712009 21715096 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015935 small ribosomal subunit The smaller of the two subunits of a ribosome. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01033299001 21712009 21715096 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01033299001 21712009 21715096 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01033299001 21712009 21715096 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01033299001 21712009 21715096 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015935 small ribosomal subunit The smaller of the two subunits of a ribosome. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01033299001 21712009 21715096 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01001480001 12136529 12197093 GSVIVG01011436001 29640510 29648656 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01028474001 8110141 8111055 GO:0009664 plant-type cell wall organization A process that results in the assembly and arrangement of constituent parts of the cellulose and pectin-containing cell wall, or in the disassembly of the cellulose and pectin-containing cell wall. This process is carried out at the cellular level. An example of this process is found in Arabidopsis thaliana. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA GSVIVG01028474001 8110141 8111055 GO:0019953 sexual reproduction The regular alternation, in the life cycle of haplontic, diplontic and diplohaplontic organisms, of meiosis and fertilization which provides for the production offspring. In diplontic organisms there is a life cycle in which the products of meiosis behave directly as gametes, fusing to form a zygote from which the diploid, or sexually reproductive polyploid, adult organism will develop. In diplohaplontic organisms a haploid phase (gametophyte) exists in the life cycle between meiosis and fertilization (e.g. higher plants, many algae and Fungi); the products of meiosis are spores that develop as haploid individuals from which haploid gametes develop to form a diploid zygote; diplohaplontic organisms show an alternation of haploid and diploid generations. In haplontic organisms meiosis occurs in the zygote, giving rise to four haploid cells (e.g. many algae and protozoa), only the zygote is diploid and this may form a resistant spore, tiding organisms over hard times. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA GSVIVG01030063001 9384934 9397632 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033528001 19994166 19995195 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01022919001 18055371 18057048 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01022919001 18055371 18057048 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01022919001 18055371 18057048 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01022919001 18055371 18057048 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01022919001 18055371 18057048 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01022919001 18055371 18057048 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01022919001 18055371 18057048 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01022919001 18055371 18057048 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01022919001 18055371 18057048 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01022526001 4360478 4369702 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01022526001 4360478 4369702 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022526001 4360478 4369702 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01022526001 4360478 4369702 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01006280001 24474839 24476058 GSVIVG01027361001 15729790 15734445 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01027361001 15729790 15734445 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025228001 3012711 3016721 GSVIVG01025997001 26112888 26132974 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01003489001 10709152 10710131 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01005668001 21045695 21062595 GSVIVG01006058001 23611013 23617607 GSVIVG01016711001 541938 544967 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01016711001 541938 544967 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01028769001 19045739 19045972 GSVIVG01031254001 767891 769924 GSVIVG01024964001 5649844 5652375 GSVIVG01017509001 9646405 9649662 GSVIVG01028896001 17723468 17727425 GO:0015746 citrate transport The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of arsenite from one side of a membrane to the other. IEA GO:0015105 arsenite transmembrane transporter activity GSVIVG01028896001 17723468 17727425 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of arsenite from one side of a membrane to the other. IEA GO:0015105 arsenite transmembrane transporter activity GSVIVG01028896001 17723468 17727425 GO:0015746 citrate transport The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, from one side of the membrane to the other. IEA GO:0015137 citrate transmembrane transporter activity GSVIVG01028896001 17723468 17727425 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, from one side of the membrane to the other. IEA GO:0015137 citrate transmembrane transporter activity GSVIVG01014434001 3721386 3724388 GSVIVG01037655001 6587061 6593530 GSVIVG01021816001 7022425 7028308 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01012840001 5975369 5979690 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012840001 5975369 5979690 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01012840001 5975369 5979690 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01012656001 392627 392974 GSVIVG01037092001 29243610 29244818 GO:0048268 clathrin coat assembly The process by which clathrin triskelia are assembled into the ordered structure known as a clathrin cage. IEA GO:0030118 clathrin coat A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes. IEA Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester. IEA GO:0005543 phospholipid binding GSVIVG01037092001 29243610 29244818 GO:0048268 clathrin coat assembly The process by which clathrin triskelia are assembled into the ordered structure known as a clathrin cage. IEA GO:0030118 clathrin coat A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes. IEA Interacting selectively and non-covalently with phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. IEA GO:0005545 phosphatidylinositol binding GSVIVG01037092001 29243610 29244818 GO:0048268 clathrin coat assembly The process by which clathrin triskelia are assembled into the ordered structure known as a clathrin cage. IEA GO:0030118 clathrin coat A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes. IEA Interacting selectively and non-covalently with a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles. IEA GO:0030276 clathrin binding GSVIVG01025464001 632497 649683 GO:0006414 translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. IEA Functions in chain elongation during polypeptide synthesis at the ribosome. IEA GO:0003746 translation elongation factor activity GSVIVG01037075001 8120762 8124112 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01037075001 8120762 8124112 Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01020976001 16042062 16042274 GSVIVG01018955001 18389367 18393847 GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA GSVIVG01023600001 7835815 7846137 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01023600001 7835815 7846137 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01023600001 7835815 7846137 GO:0017004 cytochrome complex assembly The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01023600001 7835815 7846137 GO:0017004 cytochrome complex assembly The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01023600001 7835815 7846137 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01023600001 7835815 7846137 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01023600001 7835815 7846137 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01023600001 7835815 7846137 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01023600001 7835815 7846137 GO:0017004 cytochrome complex assembly The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01023600001 7835815 7846137 GO:0017004 cytochrome complex assembly The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01023600001 7835815 7846137 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01023600001 7835815 7846137 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01023600001 7835815 7846137 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01023600001 7835815 7846137 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01023600001 7835815 7846137 GO:0017004 cytochrome complex assembly The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01023600001 7835815 7846137 GO:0017004 cytochrome complex assembly The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01023600001 7835815 7846137 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01023600001 7835815 7846137 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01023600001 7835815 7846137 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023600001 7835815 7846137 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023600001 7835815 7846137 GO:0017004 cytochrome complex assembly The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023600001 7835815 7846137 GO:0017004 cytochrome complex assembly The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023600001 7835815 7846137 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023600001 7835815 7846137 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023600001 7835815 7846137 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01023600001 7835815 7846137 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01023600001 7835815 7846137 GO:0017004 cytochrome complex assembly The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01023600001 7835815 7846137 GO:0017004 cytochrome complex assembly The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01023600001 7835815 7846137 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01023600001 7835815 7846137 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01023600001 7835815 7846137 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01023600001 7835815 7846137 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01023600001 7835815 7846137 GO:0017004 cytochrome complex assembly The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01023600001 7835815 7846137 GO:0017004 cytochrome complex assembly The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01023600001 7835815 7846137 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01023600001 7835815 7846137 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01009546001 9254405 9256571 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA GSVIVG01009546001 9254405 9256571 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GSVIVG01017452001 8726123 8728804 GSVIVG01000443001 8066019 8069151 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA GSVIVG01033181001 9060434 9112245 GO:0051276 chromosome organization A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033181001 9060434 9112245 GO:0051276 chromosome organization A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008960001 3861742 3869760 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01008960001 3861742 3869760 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01008960001 3861742 3869760 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01008960001 3861742 3869760 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01036662001 19968663 19969511 GSVIVG01030320001 8901763 8902209 GSVIVG01026883001 19663226 19665638 GSVIVG01036351001 4106981 4108226 Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01036351001 4106981 4108226 Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01019383001 197961 209292 GSVIVG01008818001 2421815 2426715 Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01008723001 1453377 1455960 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01008723001 1453377 1455960 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01006520001 42775795 42776959 GSVIVG01033776001 17940106 17962021 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01033776001 17940106 17962021 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01030146001 10288706 10291584 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01012316001 13817798 13820399 GSVIVG01000422001 7753342 7755364 GSVIVG01033062001 25458835 25462316 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033062001 25458835 25462316 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033062001 25458835 25462316 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033062001 25458835 25462316 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033062001 25458835 25462316 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033062001 25458835 25462316 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01012643001 300629 304962 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012643001 300629 304962 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012643001 300629 304962 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01012643001 300629 304962 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01012643001 300629 304962 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01012643001 300629 304962 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01012643001 300629 304962 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01012643001 300629 304962 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01010350001 19710737 19712696 GSVIVG01028030001 3306894 3310648 GSVIVG01025591001 13793341 13797771 GSVIVG01018184001 13461345 13464332 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018184001 13461345 13464332 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain. IEA GO:0004177 aminopeptidase activity GSVIVG01035882001 5217811 5232786 GO:0005985 sucrose metabolic process The chemical reactions and pathways involving sucrose, the disaccharide fructofuranosyl-glucopyranoside. IEA Catalysis of the reaction: UDP-glucose + D-fructose 6-phosphate = UDP + sucrose 6-phosphate. IEA GO:0046524 sucrose-phosphate synthase activity GSVIVG01035882001 5217811 5232786 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: UDP-glucose + D-fructose 6-phosphate = UDP + sucrose 6-phosphate. IEA GO:0046524 sucrose-phosphate synthase activity GSVIVG01033328001 21435392 21441980 GSVIVG01035285001 24525 25255 GSVIVG01037626001 6330847 6341263 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01029009001 10628176 10632064 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01029009001 10628176 10632064 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01029009001 10628176 10632064 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029009001 10628176 10632064 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029009001 10628176 10632064 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029009001 10628176 10632064 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029009001 10628176 10632064 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01029009001 10628176 10632064 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01027077001 18136473 18143872 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin. IEA GO:0004221 ubiquitin thiolesterase activity GSVIVG01006802001 28689359 28693309 GSVIVG01033357001 21240782 21242739 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01033357001 21240782 21242739 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01033357001 21240782 21242739 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01033357001 21240782 21242739 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01033357001 21240782 21242739 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01033357001 21240782 21242739 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01033357001 21240782 21242739 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01033357001 21240782 21242739 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01033357001 21240782 21242739 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01033357001 21240782 21242739 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01033357001 21240782 21242739 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033357001 21240782 21242739 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033357001 21240782 21242739 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033357001 21240782 21242739 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033357001 21240782 21242739 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033357001 21240782 21242739 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01033357001 21240782 21242739 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01033357001 21240782 21242739 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01033357001 21240782 21242739 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01033357001 21240782 21242739 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01031183001 1425106 1426730 GSVIVG01001207001 789268 810816 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01001207001 789268 810816 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. IEA GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity GSVIVG01001207001 789268 810816 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038451001 12635987 12636292 GSVIVG01006679001 27409050 27412520 GSVIVG01015324001 2694989 2699918 GSVIVG01003527001 41315 50184 GSVIVG01029109001 19599532 19603061 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029109001 19599532 19603061 GO:0016114 terpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029109001 19599532 19603061 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. IEA GO:0008661 1-deoxy-D-xylulose-5-phosphate synthase activity GSVIVG01029109001 19599532 19603061 GO:0016114 terpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure. IEA Catalysis of the reaction: pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. IEA GO:0008661 1-deoxy-D-xylulose-5-phosphate synthase activity GSVIVG01029109001 19599532 19603061 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide. IEA GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor GSVIVG01029109001 19599532 19603061 GO:0016114 terpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure. IEA Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide. IEA GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor GSVIVG01024642001 8129329 8133473 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01024642001 8129329 8133473 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01024642001 8129329 8133473 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01024642001 8129329 8133473 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01024642001 8129329 8133473 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024642001 8129329 8133473 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024642001 8129329 8133473 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024642001 8129329 8133473 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01014215001 1528687 1547441 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01014215001 1528687 1547441 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01004468001 38708004 38711099 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01019159001 15930193 15931579 GSVIVG01016182001 7002302 7004484 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01009619001 9932714 9937031 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01009619001 9932714 9937031 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01009619001 9932714 9937031 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01009619001 9932714 9937031 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01035753001 3992668 4000655 GSVIVG01027152001 17400334 17405409 GSVIVG01020220001 8905520 8916899 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020220001 8905520 8916899 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01020220001 8905520 8916899 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01034957001 441759 444928 GO:0001503 ossification The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. IEA GO:0005179 hormone activity GSVIVG01034957001 441759 444928 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. IEA GO:0005179 hormone activity GSVIVG01008046001 6316168 6320317 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01008046001 6316168 6320317 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01025960001 26572450 26573443 GSVIVG01009801001 11347342 11347947 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01009801001 11347342 11347947 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01024086001 1237994 1248575 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024086001 1237994 1248575 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: D-glyceraldehyde 3-phosphate = glycerone phosphate. IEA GO:0004807 triose-phosphate isomerase activity GSVIVG01026399001 15645008 15646649 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01012711001 876735 883328 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012711001 876735 883328 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01012711001 876735 883328 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01012711001 876735 883328 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01033060001 25427480 25440193 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01033060001 25427480 25440193 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033060001 25427480 25440193 Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01033060001 25427480 25440193 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01015213001 1870241 1872577 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01036085001 20863384 20864451 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01036085001 20863384 20864451 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01035612001 2700607 2710044 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035612001 2700607 2710044 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035612001 2700607 2710044 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01035612001 2700607 2710044 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01035612001 2700607 2710044 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01035612001 2700607 2710044 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01001509001 5332554 5333006 GSVIVG01013111001 8175757 8185460 GSVIVG01032123001 22440619 22441176 GSVIVG01002629001 35487091 35492998 GSVIVG01021426001 5227247 5235270 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01021426001 5227247 5235270 GO:0006270 DNA-dependent DNA replication initiation The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01021426001 5227247 5235270 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01021426001 5227247 5235270 GO:0015995 chlorophyll biosynthetic process The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01021426001 5227247 5235270 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01021426001 5227247 5235270 GO:0006270 DNA-dependent DNA replication initiation The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01021426001 5227247 5235270 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01021426001 5227247 5235270 GO:0015995 chlorophyll biosynthetic process The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01021426001 5227247 5235270 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021426001 5227247 5235270 GO:0006270 DNA-dependent DNA replication initiation The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021426001 5227247 5235270 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021426001 5227247 5235270 GO:0015995 chlorophyll biosynthetic process The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021426001 5227247 5235270 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + protoporphyrin IX + Mg2+ + H2O = ADP + phosphate + Mg-protoporphyrin IX + 2 H+. IEA GO:0016851 magnesium chelatase activity GSVIVG01021426001 5227247 5235270 GO:0006270 DNA-dependent DNA replication initiation The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + protoporphyrin IX + Mg2+ + H2O = ADP + phosphate + Mg-protoporphyrin IX + 2 H+. IEA GO:0016851 magnesium chelatase activity GSVIVG01021426001 5227247 5235270 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + protoporphyrin IX + Mg2+ + H2O = ADP + phosphate + Mg-protoporphyrin IX + 2 H+. IEA GO:0016851 magnesium chelatase activity GSVIVG01021426001 5227247 5235270 GO:0015995 chlorophyll biosynthetic process The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + protoporphyrin IX + Mg2+ + H2O = ADP + phosphate + Mg-protoporphyrin IX + 2 H+. IEA GO:0016851 magnesium chelatase activity GSVIVG01021426001 5227247 5235270 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01021426001 5227247 5235270 GO:0006270 DNA-dependent DNA replication initiation The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01021426001 5227247 5235270 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01021426001 5227247 5235270 GO:0015995 chlorophyll biosynthetic process The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01020134001 9995025 9997121 GSVIVG01013041001 9393862 9395234 GSVIVG01034403001 16819542 16821063 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01029063001 11700909 11750474 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029063001 11700909 11750474 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01023644001 8376954 8379299 GSVIVG01037580001 10694309 10694986 GSVIVG01032757001 992156 997287 Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum. IEA GO:0003993 acid phosphatase activity GSVIVG01014062001 20819 28405 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01014062001 20819 28405 GO:0019538 protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01014062001 20819 28405 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014062001 20819 28405 GO:0019538 protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014062001 20819 28405 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014062001 20819 28405 GO:0019538 protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014062001 20819 28405 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01014062001 20819 28405 GO:0019538 protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01014062001 20819 28405 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01014062001 20819 28405 GO:0019538 protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01004056001 564244 564913 GSVIVG01029738001 13928524 13935532 GSVIVG01034104001 15127978 15129017 GSVIVG01023216001 21019776 21020867 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01023216001 21019776 21020867 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01023216001 21019776 21020867 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01023216001 21019776 21020867 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020401001 20026272 20062932 Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0010181 FMN binding GSVIVG01020401001 20026272 20062932 Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016651 oxidoreductase activity, acting on NADH or NADPH GSVIVG01020401001 20026272 20062932 Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01020401001 20026272 20062932 Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051539 4 iron, 4 sulfur cluster binding GSVIVG01010619001 15947210 15949471 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01003981001 26461025 26461680 GSVIVG01001333001 313853 314239 GSVIVG01026868001 19778733 19781736 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01022421001 19954472 19970255 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01022421001 19954472 19970255 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01022421001 19954472 19970255 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01022421001 19954472 19970255 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01022421001 19954472 19970255 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01022421001 19954472 19970255 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01022421001 19954472 19970255 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022421001 19954472 19970255 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01023528001 10219838 10221295 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023528001 10219838 10221295 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023528001 10219838 10221295 GO:0006437 tyrosyl-tRNA aminoacylation The process of coupling tyrosine to tyrosyl-tRNA, catalyzed by tyrosyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023528001 10219838 10221295 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01023528001 10219838 10221295 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01023528001 10219838 10221295 GO:0006437 tyrosyl-tRNA aminoacylation The process of coupling tyrosine to tyrosyl-tRNA, catalyzed by tyrosyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01023528001 10219838 10221295 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01023528001 10219838 10221295 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01023528001 10219838 10221295 GO:0006437 tyrosyl-tRNA aminoacylation The process of coupling tyrosine to tyrosyl-tRNA, catalyzed by tyrosyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01023528001 10219838 10221295 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr). IEA GO:0004831 tyrosine-tRNA ligase activity GSVIVG01023528001 10219838 10221295 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr). IEA GO:0004831 tyrosine-tRNA ligase activity GSVIVG01023528001 10219838 10221295 GO:0006437 tyrosyl-tRNA aminoacylation The process of coupling tyrosine to tyrosyl-tRNA, catalyzed by tyrosyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr). IEA GO:0004831 tyrosine-tRNA ligase activity GSVIVG01023528001 10219838 10221295 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023528001 10219838 10221295 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023528001 10219838 10221295 GO:0006437 tyrosyl-tRNA aminoacylation The process of coupling tyrosine to tyrosyl-tRNA, catalyzed by tyrosyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000163001 15768283 15796141 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01015369001 3057526 3060231 Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. IEA GO:0005089 Rho guanyl-nucleotide exchange factor activity GSVIVG01013454001 325071 327505 GSVIVG01036325001 3847565 3864332 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01036325001 3847565 3864332 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01035876001 5150331 5155629 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01035876001 5150331 5155629 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01032996001 24952041 24957767 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: ATP + L-aspartate = ADP + 4-phospho-L-aspartate. IEA GO:0004072 aspartate kinase activity GSVIVG01032996001 24952041 24957767 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the reaction: ATP + L-aspartate = ADP + 4-phospho-L-aspartate. IEA GO:0004072 aspartate kinase activity GSVIVG01032996001 24952041 24957767 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. IEA GO:0016597 amino acid binding GSVIVG01032996001 24952041 24957767 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. IEA GO:0016597 amino acid binding GSVIVG01030967001 19950410 19965299 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with manganese (Mn) ions. IEA GO:0030145 manganese ion binding GSVIVG01030967001 19950410 19965299 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Functions in the storage of nutritious substrates. IEA GO:0045735 nutrient reservoir activity GSVIVG01025114001 4320266 4324243 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0000159 protein phosphatase type 2A complex A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit. IEA Modulation of the activity of the enzyme protein phosphatase type 2A. IEA GO:0008601 protein phosphatase type 2A regulator activity GSVIVG01022300001 18330315 18345510 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01022300001 18330315 18345510 Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA. IEA GO:0004540 ribonuclease activity GSVIVG01006480001 26368946 26376275 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01006480001 26368946 26376275 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01006480001 26368946 26376275 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01006480001 26368946 26376275 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01006480001 26368946 26376275 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01006480001 26368946 26376275 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01006480001 26368946 26376275 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006480001 26368946 26376275 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006480001 26368946 26376275 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01006480001 26368946 26376275 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01032550001 28275211 28278223 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01032550001 28275211 28278223 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01003141001 7600049 7602393 GSVIVG01008328001 3215529 3219814 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01008328001 3215529 3219814 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01008328001 3215529 3219814 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01008328001 3215529 3219814 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003335001 9143310 9146246 GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Prevents the dissociation of GDP from the small GTPase Rho, thereby preventing GTP from binding. IEA GO:0005094 Rho GDP-dissociation inhibitor activity GSVIVG01003973001 26410238 26412677 GSVIVG01023333001 19647984 19649341 GSVIVG01034009001 15939370 15940479 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01012120001 1248327 1254994 GO:0006164 purine nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012120001 1248327 1254994 GO:0006188 IMP biosynthetic process The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012120001 1248327 1254994 GO:0006164 purine nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. IEA Catalysis of the reaction: IMP + H2O = 5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide. IEA GO:0003937 IMP cyclohydrolase activity GSVIVG01012120001 1248327 1254994 GO:0006188 IMP biosynthetic process The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate. IEA Catalysis of the reaction: IMP + H2O = 5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide. IEA GO:0003937 IMP cyclohydrolase activity GSVIVG01012120001 1248327 1254994 GO:0006164 purine nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. IEA Catalysis of the reaction: 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide = tetrahydrofolate + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide. IEA GO:0004643 phosphoribosylaminoimidazolecarboxamide formyltransferase activity GSVIVG01012120001 1248327 1254994 GO:0006188 IMP biosynthetic process The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate. IEA Catalysis of the reaction: 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide = tetrahydrofolate + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide. IEA GO:0004643 phosphoribosylaminoimidazolecarboxamide formyltransferase activity GSVIVG01021186001 2377799 2409593 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01012122001 1242559 1244964 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Interacting selectively and non-covalently with damaged DNA. IEA GO:0003684 damaged DNA binding GSVIVG01012122001 1242559 1244964 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA Interacting selectively and non-covalently with damaged DNA. IEA GO:0003684 damaged DNA binding GSVIVG01012122001 1242559 1244964 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012122001 1242559 1244964 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012122001 1242559 1244964 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Interacting selectively and non-covalently with nickel (Ni) ions. IEA GO:0016151 nickel ion binding GSVIVG01012122001 1242559 1244964 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA Interacting selectively and non-covalently with nickel (Ni) ions. IEA GO:0016151 nickel ion binding GSVIVG01020233001 8775791 8787091 GO:0006397 mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020233001 8775791 8787091 GO:0006397 mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01020233001 8775791 8787091 GO:0006397 mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. IEA The action of a molecule that contributes to the structural integrity of a cell wall. IEA GO:0005199 structural constituent of cell wall GSVIVG01036388001 4529837 4530370 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01036388001 4529837 4530370 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01005296001 20338459 20379269 GSVIVG01010738001 21972250 21973645 GSVIVG01009804001 11374221 11381696 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01021312001 3852106 3878590 GO:0005992 trehalose biosynthetic process The chemical reactions and pathways resulting in the formation of trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01037059001 8252532 8257124 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004185 serine-type carboxypeptidase activity GSVIVG01032726001 1228756 1242071 GSVIVG01022936001 17813638 17815284 GSVIVG01018923001 18617295 18620099 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018923001 18617295 18620099 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01018923001 18617295 18620099 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01015259001 2168574 2170745 GSVIVG01037284001 16492569 16494773 GSVIVG01030846001 17518670 17520154 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01018291001 11695555 11698149 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01018291001 11695555 11698149 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01018291001 11695555 11698149 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01018291001 11695555 11698149 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01018291001 11695555 11698149 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01018291001 11695555 11698149 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018291001 11695555 11698149 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018291001 11695555 11698149 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018291001 11695555 11698149 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018291001 11695555 11698149 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018291001 11695555 11698149 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01018291001 11695555 11698149 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01018291001 11695555 11698149 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01018291001 11695555 11698149 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01018291001 11695555 11698149 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01003225001 14194102 14198256 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01022468001 3386260 3417708 GO:0015684 ferrous iron transport The directed movement of ferrous iron (Fe(II) or Fe2+) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01022468001 3386260 3417708 GO:0015684 ferrous iron transport The directed movement of ferrous iron (Fe(II) or Fe2+) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01022468001 3386260 3417708 GO:0015684 ferrous iron transport The directed movement of ferrous iron (Fe(II) or Fe2+) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the transfer of ferrous iron (Fe(II) or Fe2+) ions from one side of a membrane to the other. IEA GO:0015093 ferrous iron transmembrane transporter activity GSVIVG01022468001 3386260 3417708 GO:0015684 ferrous iron transport The directed movement of ferrous iron (Fe(II) or Fe2+) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of ferrous iron (Fe(II) or Fe2+) ions from one side of a membrane to the other. IEA GO:0015093 ferrous iron transmembrane transporter activity GSVIVG01027803001 7949427 7953006 GSVIVG01021712001 9919278 9920931 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01021712001 9919278 9920931 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01021712001 9919278 9920931 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01021712001 9919278 9920931 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01021712001 9919278 9920931 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021712001 9919278 9920931 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021712001 9919278 9920931 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021712001 9919278 9920931 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021712001 9919278 9920931 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with manganese (Mn) ions. IEA GO:0030145 manganese ion binding GSVIVG01021712001 9919278 9920931 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with manganese (Mn) ions. IEA GO:0030145 manganese ion binding GSVIVG01021712001 9919278 9920931 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with manganese (Mn) ions. IEA GO:0030145 manganese ion binding GSVIVG01021712001 9919278 9920931 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with manganese (Mn) ions. IEA GO:0030145 manganese ion binding GSVIVG01021712001 9919278 9920931 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Functions in the storage of nutritious substrates. IEA GO:0045735 nutrient reservoir activity GSVIVG01021712001 9919278 9920931 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Functions in the storage of nutritious substrates. IEA GO:0045735 nutrient reservoir activity GSVIVG01021712001 9919278 9920931 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Functions in the storage of nutritious substrates. IEA GO:0045735 nutrient reservoir activity GSVIVG01021712001 9919278 9920931 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Functions in the storage of nutritious substrates. IEA GO:0045735 nutrient reservoir activity GSVIVG01021712001 9919278 9920931 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01021712001 9919278 9920931 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01021712001 9919278 9920931 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01021712001 9919278 9920931 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01013015001 10191223 10201433 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01013015001 10191223 10201433 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01013015001 10191223 10201433 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate. IEA GO:0019001 guanyl nucleotide binding GSVIVG01013015001 10191223 10201433 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate. IEA GO:0019001 guanyl nucleotide binding GSVIVG01012628001 190065 195087 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01018311001 11264616 11265577 GSVIVG01024527001 9155464 9213374 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01024527001 9155464 9213374 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01024527001 9155464 9213374 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024527001 9155464 9213374 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024527001 9155464 9213374 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01024527001 9155464 9213374 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01024527001 9155464 9213374 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01024527001 9155464 9213374 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01024527001 9155464 9213374 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01024527001 9155464 9213374 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01025333001 1917990 1921800 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0008021 synaptic vesicle A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and is secreted these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01025333001 1917990 1921800 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01032196001 21626858 21631768 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01032196001 21626858 21631768 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01032196001 21626858 21631768 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0015934 large ribosomal subunit The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01032196001 21626858 21631768 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01032196001 21626858 21631768 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01032196001 21626858 21631768 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015934 large ribosomal subunit The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01032196001 21626858 21631768 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01032196001 21626858 21631768 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01032196001 21626858 21631768 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0015934 large ribosomal subunit The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01032196001 21626858 21631768 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01032196001 21626858 21631768 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01032196001 21626858 21631768 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015934 large ribosomal subunit The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01038253001 24721429 24725735 GSVIVG01009308001 7253935 7254270 GSVIVG01021326001 4055584 4057634 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01021326001 4055584 4057634 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01011510001 30192961 30203567 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01011510001 30192961 30203567 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01011510001 30192961 30203567 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01011510001 30192961 30203567 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01023971001 2034767 2037175 GSVIVG01017864001 4115615 4117564 GSVIVG01008662001 44411 46742 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01008662001 44411 46742 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01016393001 4249970 4255614 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01038406001 11838745 11839682 GSVIVG01006061001 40953133 40953366 GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. IEA GO:0033179 proton-transporting V-type ATPase, V0 domain A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01006061001 40953133 40953366 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0033179 proton-transporting V-type ATPase, V0 domain A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01006061001 40953133 40953366 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033179 proton-transporting V-type ATPase, V0 domain A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01006061001 40953133 40953366 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0033179 proton-transporting V-type ATPase, V0 domain A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01006061001 40953133 40953366 GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. IEA GO:0033179 proton-transporting V-type ATPase, V0 domain A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring. IEA Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+. IEA GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity GSVIVG01006061001 40953133 40953366 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0033179 proton-transporting V-type ATPase, V0 domain A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring. IEA Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+. IEA GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity GSVIVG01006061001 40953133 40953366 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033179 proton-transporting V-type ATPase, V0 domain A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring. IEA Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+. IEA GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity GSVIVG01006061001 40953133 40953366 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0033179 proton-transporting V-type ATPase, V0 domain A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring. IEA Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+. IEA GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity GSVIVG01006061001 40953133 40953366 GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. IEA GO:0033179 proton-transporting V-type ATPase, V0 domain A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01006061001 40953133 40953366 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0033179 proton-transporting V-type ATPase, V0 domain A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01006061001 40953133 40953366 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033179 proton-transporting V-type ATPase, V0 domain A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01006061001 40953133 40953366 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0033179 proton-transporting V-type ATPase, V0 domain A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01006061001 40953133 40953366 GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. IEA GO:0033179 proton-transporting V-type ATPase, V0 domain A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01006061001 40953133 40953366 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0033179 proton-transporting V-type ATPase, V0 domain A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01006061001 40953133 40953366 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033179 proton-transporting V-type ATPase, V0 domain A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01006061001 40953133 40953366 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0033179 proton-transporting V-type ATPase, V0 domain A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01009002001 4176691 4180053 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01020366001 20500225 20510750 GSVIVG01003814001 367021 367269 GSVIVG01026512001 22411378 22436792 GSVIVG01019353001 586033 587491 GSVIVG01010810001 22881865 22883976 GSVIVG01020385001 20274021 20274296 GSVIVG01000801001 268087 268574 GSVIVG01003355001 9297518 9305231 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01033679001 18741419 18746917 GSVIVG01029731001 13826463 13828618 GSVIVG01029250001 18010842 18015419 GSVIVG01019408001 422317 424434 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01012558001 3563462 3564445 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01034351001 17691765 17698618 GSVIVG01032936001 24341805 24359981 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01032936001 24341805 24359981 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds. IEA GO:0015035 protein disulfide oxidoreductase activity GSVIVG01027480001 16442203 16444527 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01003764001 12479314 12484400 GSVIVG01027623001 14956381 14973839 GO:0032012 regulation of ARF protein signal transduction Any process that modulates the frequency, rate or extent of ARF protein signal transduction. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Stimulates the exchange of guanyl nucleotides associated with the GTPase ARF. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. IEA GO:0005086 ARF guanyl-nucleotide exchange factor activity GSVIVG01027623001 14956381 14973839 GO:0032012 regulation of ARF protein signal transduction Any process that modulates the frequency, rate or extent of ARF protein signal transduction. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01021267001 3219089 3219676 GSVIVG01014617001 5753821 5754800 GSVIVG01033441001 20668185 20672685 GSVIVG01020253001 22233245 22235162 GSVIVG01014758001 9349179 9350972 GO:0019941 modification-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01014758001 9349179 9350972 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01014758001 9349179 9350972 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01014758001 9349179 9350972 GO:0019941 modification-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01014758001 9349179 9350972 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01014758001 9349179 9350972 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01034956001 431248 437819 GSVIVG01033046001 25316395 25318488 GSVIVG01017691001 2683950 2685430 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012328001 175713 180137 GSVIVG01034132001 14953586 14958217 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01020833001 1410810 1411067 GSVIVG01023905001 2549517 2565520 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01023905001 2549517 2565520 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01032404001 27051487 27063649 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01032404001 27051487 27063649 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01032404001 27051487 27063649 GO:0015833 peptide transport The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01032404001 27051487 27063649 GO:0015833 peptide transport The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01032404001 27051487 27063649 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01032404001 27051487 27063649 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01032404001 27051487 27063649 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032404001 27051487 27063649 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032404001 27051487 27063649 GO:0015833 peptide transport The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032404001 27051487 27063649 GO:0015833 peptide transport The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032404001 27051487 27063649 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032404001 27051487 27063649 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032404001 27051487 27063649 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of, within or between cells. IEA GO:0015197 peptide transporter activity GSVIVG01032404001 27051487 27063649 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of, within or between cells. IEA GO:0015197 peptide transporter activity GSVIVG01032404001 27051487 27063649 GO:0015833 peptide transport The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of, within or between cells. IEA GO:0015197 peptide transporter activity GSVIVG01032404001 27051487 27063649 GO:0015833 peptide transport The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of, within or between cells. IEA GO:0015197 peptide transporter activity GSVIVG01032404001 27051487 27063649 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of, within or between cells. IEA GO:0015197 peptide transporter activity GSVIVG01032404001 27051487 27063649 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of, within or between cells. IEA GO:0015197 peptide transporter activity GSVIVG01032404001 27051487 27063649 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01032404001 27051487 27063649 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01032404001 27051487 27063649 GO:0015833 peptide transport The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01032404001 27051487 27063649 GO:0015833 peptide transport The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01032404001 27051487 27063649 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01032404001 27051487 27063649 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01032404001 27051487 27063649 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01032404001 27051487 27063649 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01032404001 27051487 27063649 GO:0015833 peptide transport The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01032404001 27051487 27063649 GO:0015833 peptide transport The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01032404001 27051487 27063649 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01032404001 27051487 27063649 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01032404001 27051487 27063649 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01032404001 27051487 27063649 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01032404001 27051487 27063649 GO:0015833 peptide transport The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01032404001 27051487 27063649 GO:0015833 peptide transport The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01032404001 27051487 27063649 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01032404001 27051487 27063649 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01011870001 3396142 3407109 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: D-mannose 6-phosphate = D-fructose 6-phosphate. IEA GO:0004476 mannose-6-phosphate isomerase activity GSVIVG01011870001 3396142 3407109 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008011001 6701815 6702672 GSVIVG01008109001 5711518 5719116 GSVIVG01003790001 12750115 12751228 GSVIVG01019271001 2230223 2236094 GSVIVG01029150001 19103861 19124799 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01012147001 1060701 1062011 GSVIVG01031293001 581764 581862 GSVIVG01013970001 8182198 8182456 GSVIVG01035109001 1538530 1539312 GSVIVG01023051001 16341929 16348554 GSVIVG01010431001 20542070 20544780 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01010955001 2669799 2683357 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of potassium ions (K+) from one side of a membrane to the other. IEA GO:0015079 potassium ion transmembrane transporter activity GSVIVG01008070001 6076049 6081450 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01008070001 6076049 6081450 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01008070001 6076049 6081450 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01008070001 6076049 6081450 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01008070001 6076049 6081450 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000027001 2909953 2914570 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01035092001 1421204 1424461 GSVIVG01008095001 5826970 5832055 GO:0009396 folic acid and derivative biosynthetic process The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008095001 5826970 5832055 GO:0009396 folic acid and derivative biosynthetic process The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. IEA Catalysis of the reaction: ATP + 5-formyltetrahydrofolate = ADP + phosphate + 5,10-methenyltetrahydrofolate. IEA GO:0030272 5-formyltetrahydrofolate cyclo-ligase activity GSVIVG01031674001 19975589 19979672 GSVIVG01023562001 9641947 9643200 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01023562001 9641947 9643200 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01023562001 9641947 9643200 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01023562001 9641947 9643200 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01032452001 27556527 27560472 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01017910001 4554257 4559694 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01017910001 4554257 4559694 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01017910001 4554257 4559694 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01017910001 4554257 4559694 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017910001 4554257 4559694 Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01017910001 4554257 4559694 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01007549001 12284470 12313319 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01007549001 12284470 12313319 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01007549001 12284470 12313319 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01007549001 12284470 12313319 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01007549001 12284470 12313319 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01007549001 12284470 12313319 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01006739001 27927662 27931198 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01006739001 27927662 27931198 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01006739001 27927662 27931198 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01006739001 27927662 27931198 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028343001 6291110 6348702 GO:0051276 chromosome organization A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01028343001 6291110 6348702 GO:0051276 chromosome organization A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013539001 20385240 20410166 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01037040001 8486713 8618755 Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01037040001 8486713 8618755 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01037040001 8486713 8618755 Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01037040001 8486713 8618755 Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01034328001 18067361 18085523 GSVIVG01028202001 4585465 4588818 GSVIVG01016521001 3175766 3182587 GSVIVG01030779001 15847690 15876701 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01021124001 1675524 1676398 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01021124001 1675524 1676398 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds. IEA GO:0015035 protein disulfide oxidoreductase activity GSVIVG01016925001 2626915 2651601 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01016925001 2626915 2651601 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01016925001 2626915 2651601 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01016925001 2626915 2651601 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016925001 2626915 2651601 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028314001 6029368 6029826 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01028314001 6029368 6029826 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01019068001 17142613 17150031 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0009317 acetyl-CoA carboxylase complex A protein complex that catalyzes the first step in long-chain fatty acid biosynthesis. For example, in E. coli the complex is heterohexameric and composed of biotin carbonyl carrier protein, biotin carboxylase and the acetate CoA-transferase complex. IEA Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA. IEA GO:0003989 acetyl-CoA carboxylase activity GSVIVG01019068001 17142613 17150031 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA GO:0009317 acetyl-CoA carboxylase complex A protein complex that catalyzes the first step in long-chain fatty acid biosynthesis. For example, in E. coli the complex is heterohexameric and composed of biotin carbonyl carrier protein, biotin carboxylase and the acetate CoA-transferase complex. IEA Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA. IEA GO:0003989 acetyl-CoA carboxylase activity GSVIVG01019068001 17142613 17150031 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA GO:0009317 acetyl-CoA carboxylase complex A protein complex that catalyzes the first step in long-chain fatty acid biosynthesis. For example, in E. coli the complex is heterohexameric and composed of biotin carbonyl carrier protein, biotin carboxylase and the acetate CoA-transferase complex. IEA Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA. IEA GO:0003989 acetyl-CoA carboxylase activity GSVIVG01019068001 17142613 17150031 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0009317 acetyl-CoA carboxylase complex A protein complex that catalyzes the first step in long-chain fatty acid biosynthesis. For example, in E. coli the complex is heterohexameric and composed of biotin carbonyl carrier protein, biotin carboxylase and the acetate CoA-transferase complex. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01019068001 17142613 17150031 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA GO:0009317 acetyl-CoA carboxylase complex A protein complex that catalyzes the first step in long-chain fatty acid biosynthesis. For example, in E. coli the complex is heterohexameric and composed of biotin carbonyl carrier protein, biotin carboxylase and the acetate CoA-transferase complex. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01019068001 17142613 17150031 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA GO:0009317 acetyl-CoA carboxylase complex A protein complex that catalyzes the first step in long-chain fatty acid biosynthesis. For example, in E. coli the complex is heterohexameric and composed of biotin carbonyl carrier protein, biotin carboxylase and the acetate CoA-transferase complex. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01017859001 4088416 4095100 GSVIVG01023848001 3000469 3006751 GSVIVG01021153001 1875979 1880329 GO:0006461 protein complex assembly The aggregation, arrangement and bonding together of a set of components to form a protein complex. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA GSVIVG01008007001 6737153 6740262 GSVIVG01003151001 6198943 6211821 GSVIVG01021845001 6596774 6597795 GSVIVG01010309001 19281786 19282972 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01030151001 10337071 10340693 GSVIVG01012672001 507749 508892 GSVIVG01037334001 15546634 15547373 GO:0006094 gluconeogenesis The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. IEA Catalysis of the reaction: D-glucose 6-phosphate = D-fructose 6-phosphate. IEA GO:0004347 glucose-6-phosphate isomerase activity GSVIVG01037334001 15546634 15547373 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the reaction: D-glucose 6-phosphate = D-fructose 6-phosphate. IEA GO:0004347 glucose-6-phosphate isomerase activity GSVIVG01024471001 3063881 3066717 GSVIVG01012883001 6503756 6504121 GSVIVG01012229001 397351 400531 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01022102001 16593089 16593470 GSVIVG01003496001 10745115 10769646 GSVIVG01035540001 2148061 2148714 GSVIVG01034105001 15127085 15127978 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033735001 18233653 18236355 GSVIVG01014516001 4715855 4721730 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014516001 4715855 4721730 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001053001 7108567 7114040 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01001053001 7108567 7114040 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01009091001 4972234 4973975 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01009091001 4972234 4973975 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01003325001 9065348 9065473 GSVIVG01014961001 13001509 13011984 GSVIVG01027380001 15502234 15510624 GSVIVG01002113001 33009792 33015697 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01002113001 33009792 33015697 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01002113001 33009792 33015697 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036486001 22598873 22609602 GSVIVG01023270001 20398305 20405552 GSVIVG01011225001 9803990 9816760 GSVIVG01037193001 28120533 28137285 Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01037193001 28120533 28137285 Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01029161001 19007670 19010594 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01034685001 7658584 7659542 Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. IEA GO:0008171 O-methyltransferase activity GSVIVG01015830001 18008254 18010868 GSVIVG01014165001 1012164 1014463 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01014165001 1012164 1014463 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01014165001 1012164 1014463 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01014165001 1012164 1014463 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01014165001 1012164 1014463 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01014165001 1012164 1014463 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01014165001 1012164 1014463 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01014165001 1012164 1014463 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01014165001 1012164 1014463 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01014165001 1012164 1014463 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01014165001 1012164 1014463 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014165001 1012164 1014463 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014165001 1012164 1014463 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014165001 1012164 1014463 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014165001 1012164 1014463 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014165001 1012164 1014463 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01014165001 1012164 1014463 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01014165001 1012164 1014463 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01014165001 1012164 1014463 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01014165001 1012164 1014463 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01006736001 27854699 27857074 GSVIVG01032473001 27739062 27740646 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01020802001 1778998 1792093 GSVIVG01032367001 26757719 26764617 GSVIVG01019019001 17674974 17681364 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GSVIVG01015059001 776141 781452 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with follicle-stimulating hormone to initiate a change in cell activity. IEA GO:0004963 follicle-stimulating hormone receptor activity GSVIVG01015059001 776141 781452 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with follicle-stimulating hormone to initiate a change in cell activity. IEA GO:0004963 follicle-stimulating hormone receptor activity GSVIVG01015059001 776141 781452 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: 3-alpha(S)-strictosidine = tryptamine + secologanin. IEA GO:0016844 strictosidine synthase activity GSVIVG01015059001 776141 781452 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: 3-alpha(S)-strictosidine = tryptamine + secologanin. IEA GO:0016844 strictosidine synthase activity GSVIVG01017144001 4572419 4572523 GSVIVG01027004001 18622263 18628502 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01037258001 16865146 16868072 GSVIVG01030149001 10311165 10312078 GSVIVG01017156001 4821806 4838497 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017156001 4821806 4838497 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01017156001 4821806 4838497 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01013914001 6692473 6693594 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01013914001 6692473 6693594 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01038127001 23679891 23690900 GSVIVG01016632001 2327909 2328955 GSVIVG01026847001 19993006 19993926 GSVIVG01009643001 10145977 10147817 GSVIVG01019297001 1765842 1766963 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01036484001 22580921 22585204 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01036484001 22580921 22585204 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036484001 22580921 22585204 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01010303001 19226855 19229542 GSVIVG01036444001 22001354 22012585 GSVIVG01014379001 3246771 3250280 GSVIVG01009099001 5029707 5032279 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001945001 15149127 15167106 GSVIVG01022286001 18225070 18225477 GSVIVG01037524001 12257670 12260421 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01037524001 12257670 12260421 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01037524001 12257670 12260421 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01028750001 19193725 19196236 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028750001 19193725 19196236 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01028750001 19193725 19196236 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01025919001 27237099 27243046 GSVIVG01000198001 16039699 16055149 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01000198001 16039699 16055149 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01000198001 16039699 16055149 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01000198001 16039699 16055149 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01033197001 9417305 9419688 GSVIVG01031266001 687104 689034 GSVIVG01023016001 16858838 16862617 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01023016001 16858838 16862617 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01035059001 1242418 1243351 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GSVIVG01035059001 1242418 1243351 GO:0009607 response to biotic stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism. IEA GSVIVG01012193001 656270 666920 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012193001 656270 666920 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01012193001 656270 666920 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01012193001 656270 666920 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01024572001 8696058 8697877 GO:0009664 plant-type cell wall organization A process that results in the assembly and arrangement of constituent parts of the cellulose and pectin-containing cell wall, or in the disassembly of the cellulose and pectin-containing cell wall. This process is carried out at the cellular level. An example of this process is found in Arabidopsis thaliana. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA GSVIVG01013447001 397216 398057 GSVIVG01027083001 18082173 18101648 Catalysis of the transfer of a nucleotidyl group to a reactant. IEA GO:0016779 nucleotidyltransferase activity GSVIVG01025735001 12423920 12466184 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025735001 12423920 12466184 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025735001 12423920 12466184 GO:0006427 histidyl-tRNA aminoacylation The process of coupling histidine to histidyl-tRNA, catalyzed by histidyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025735001 12423920 12466184 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01025735001 12423920 12466184 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01025735001 12423920 12466184 GO:0006427 histidyl-tRNA aminoacylation The process of coupling histidine to histidyl-tRNA, catalyzed by histidyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01025735001 12423920 12466184 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His). IEA GO:0004821 histidine-tRNA ligase activity GSVIVG01025735001 12423920 12466184 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His). IEA GO:0004821 histidine-tRNA ligase activity GSVIVG01025735001 12423920 12466184 GO:0006427 histidyl-tRNA aminoacylation The process of coupling histidine to histidyl-tRNA, catalyzed by histidyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His). IEA GO:0004821 histidine-tRNA ligase activity GSVIVG01025735001 12423920 12466184 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025735001 12423920 12466184 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025735001 12423920 12466184 GO:0006427 histidyl-tRNA aminoacylation The process of coupling histidine to histidyl-tRNA, catalyzed by histidyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030511001 6341675 6351993 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01030511001 6341675 6351993 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030511001 6341675 6351993 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01030511001 6341675 6351993 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01031963001 5760788 5767481 GSVIVG01024565001 8824205 8825900 GSVIVG01027476001 16454590 16456057 GSVIVG01015382001 3153636 3162167 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01005489001 40427669 40428004 GSVIVG01017850001 4007203 4024721 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01017850001 4007203 4024721 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017850001 4007203 4024721 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01017850001 4007203 4024721 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01017850001 4007203 4024721 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA Catalysis of the reaction: ATP + pyruvate + phosphate = AMP + phosphoenolpyruvate + diphosphate. IEA GO:0050242 pyruvate, phosphate dikinase activity GSVIVG01028044001 3392426 3394784 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01003957001 14041600 14044192 GSVIVG01022968001 17429946 17434864 GSVIVG01017743001 3068210 3074183 GSVIVG01013101001 8280640 8285351 GO:0006506 GPI anchor biosynthetic process The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol moiety is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate moiety, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage. IEA GO:0005789 endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum. IEA GSVIVG01034767001 21155002 21155451 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01021924001 5521748 5524149 GSVIVG01021250001 2968131 2975403 GSVIVG01036373001 4318038 4319277 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01003107001 7291896 7292033 GSVIVG01023402001 12478840 12479584 GSVIVG01030440001 5568627 5571330 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: adenosine 3',5'-bisphosphate + sulfite + thioredoxin disulfide = 3'-phosphoadenosine 5'-phosphosulfate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin; 3'-phosphoadenosine 5'-phosphosulfate is also known as PAPS. IEA GO:0004604 phosphoadenylyl-sulfate reductase (thioredoxin) activity GSVIVG01030440001 5568627 5571330 GO:0019344 cysteine biosynthetic process The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid. IEA Catalysis of the reaction: adenosine 3',5'-bisphosphate + sulfite + thioredoxin disulfide = 3'-phosphoadenosine 5'-phosphosulfate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin; 3'-phosphoadenosine 5'-phosphosulfate is also known as PAPS. IEA GO:0004604 phosphoadenylyl-sulfate reductase (thioredoxin) activity GSVIVG01030440001 5568627 5571330 GO:0019419 sulfate reduction The chemical reactions and pathways resulting in the reduction of sulfate to another sulfur-containing ion or compound such as hydrogen sulfide, adenosine-phosphosulfate (APS) or thiosulfate. IEA Catalysis of the reaction: adenosine 3',5'-bisphosphate + sulfite + thioredoxin disulfide = 3'-phosphoadenosine 5'-phosphosulfate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin; 3'-phosphoadenosine 5'-phosphosulfate is also known as PAPS. IEA GO:0004604 phosphoadenylyl-sulfate reductase (thioredoxin) activity GSVIVG01030440001 5568627 5571330 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Catalysis of the reaction: adenosine 3',5'-bisphosphate + sulfite + thioredoxin disulfide = 3'-phosphoadenosine 5'-phosphosulfate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin; 3'-phosphoadenosine 5'-phosphosulfate is also known as PAPS. IEA GO:0004604 phosphoadenylyl-sulfate reductase (thioredoxin) activity GSVIVG01030440001 5568627 5571330 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: adenosine 3',5'-bisphosphate + sulfite + thioredoxin disulfide = 3'-phosphoadenosine 5'-phosphosulfate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin; 3'-phosphoadenosine 5'-phosphosulfate is also known as PAPS. IEA GO:0004604 phosphoadenylyl-sulfate reductase (thioredoxin) activity GSVIVG01030440001 5568627 5571330 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide. IEA GO:0016671 oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor GSVIVG01030440001 5568627 5571330 GO:0019344 cysteine biosynthetic process The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid. IEA Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide. IEA GO:0016671 oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor GSVIVG01030440001 5568627 5571330 GO:0019419 sulfate reduction The chemical reactions and pathways resulting in the reduction of sulfate to another sulfur-containing ion or compound such as hydrogen sulfide, adenosine-phosphosulfate (APS) or thiosulfate. IEA Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide. IEA GO:0016671 oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor GSVIVG01030440001 5568627 5571330 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide. IEA GO:0016671 oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor GSVIVG01030440001 5568627 5571330 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide. IEA GO:0016671 oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor GSVIVG01030440001 5568627 5571330 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01030440001 5568627 5571330 GO:0019344 cysteine biosynthetic process The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01030440001 5568627 5571330 GO:0019419 sulfate reduction The chemical reactions and pathways resulting in the reduction of sulfate to another sulfur-containing ion or compound such as hydrogen sulfide, adenosine-phosphosulfate (APS) or thiosulfate. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01030440001 5568627 5571330 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01030440001 5568627 5571330 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01001583001 5541919 5551415 GSVIVG01036058001 21286826 21293262 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA GSVIVG01023716001 9932821 9943110 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017215001 5518323 5525522 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01017215001 5518323 5525522 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain. IEA GO:0004177 aminopeptidase activity GSVIVG01031767001 4238893 4239063 GSVIVG01001064001 7208639 7209726 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001064001 7208639 7209726 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001064001 7208639 7209726 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01001064001 7208639 7209726 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01001064001 7208639 7209726 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01001064001 7208639 7209726 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01001064001 7208639 7209726 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01001064001 7208639 7209726 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01036901001 17957867 17976378 GSVIVG01035865001 5017843 5022700 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029219001 18415748 18418615 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01029219001 18415748 18418615 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01029219001 18415748 18418615 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01029219001 18415748 18418615 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01029219001 18415748 18418615 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01029219001 18415748 18418615 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01029219001 18415748 18418615 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01029219001 18415748 18418615 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01029219001 18415748 18418615 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01035802001 4494804 4501943 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c The transfer of electrons from ubiquinol to cytochrome c that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex III. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+. IEA GO:0008121 ubiquinol-cytochrome-c reductase activity GSVIVG01019344001 759831 763593 GSVIVG01022364001 19044008 19052032 GO:0009306 protein secretion The controlled release of proteins from a cell or group of cells. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. IEA GO:0016853 isomerase activity GSVIVG01022364001 19044008 19052032 GO:0009306 protein secretion The controlled release of proteins from a cell or group of cells. IEA GO:0005788 endoplasmic reticulum lumen The volume enclosed by the membranes of the endoplasmic reticulum. IEA Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. IEA GO:0016853 isomerase activity GSVIVG01022364001 19044008 19052032 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. IEA GO:0016853 isomerase activity GSVIVG01022364001 19044008 19052032 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GO:0005788 endoplasmic reticulum lumen The volume enclosed by the membranes of the endoplasmic reticulum. IEA Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. IEA GO:0016853 isomerase activity GSVIVG01028198001 4556805 4558017 GSVIVG01003334001 9135550 9141461 GSVIVG01034783001 21551208 21566009 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01034783001 21551208 21566009 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01034783001 21551208 21566009 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01034783001 21551208 21566009 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01034783001 21551208 21566009 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01034783001 21551208 21566009 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01029437001 22904970 22906281 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01034183001 14585704 14588173 GSVIVG01027085001 18071376 18073084 GO:0005992 trehalose biosynthetic process The chemical reactions and pathways resulting in the formation of trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027085001 18071376 18073084 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01034269001 13792213 13843698 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin. IEA GO:0004221 ubiquitin thiolesterase activity GSVIVG01024713001 7527765 7531758 GO:0006529 asparagine biosynthetic process The chemical reactions and pathways resulting in the formation of asparagine, 2-amino-3-carbamoylpropanoic acid. IEA Catalysis of the reaction: ATP + L-aspartate + L-glutamine = AMP + diphosphate + L-asparagine + L-glutamate. IEA GO:0004066 asparagine synthase (glutamine-hydrolyzing) activity GSVIVG01024713001 7527765 7531758 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: ATP + L-aspartate + L-glutamine = AMP + diphosphate + L-asparagine + L-glutamate. IEA GO:0004066 asparagine synthase (glutamine-hydrolyzing) activity GSVIVG01029165001 18992835 18994165 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01029165001 18992835 18994165 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01029165001 18992835 18994165 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01029165001 18992835 18994165 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01029165001 18992835 18994165 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01029165001 18992835 18994165 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01029165001 18992835 18994165 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01029165001 18992835 18994165 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01027506001 16152065 16157785 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01027506001 16152065 16157785 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01027506001 16152065 16157785 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01027506001 16152065 16157785 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034013001 15886350 15889386 GSVIVG01025902001 27367072 27377291 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025902001 27367072 27377291 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025902001 27367072 27377291 Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01025902001 27367072 27377291 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01032614001 2199375 2205993 GSVIVG01018863001 19138458 19141545 GSVIVG01003427001 14892870 14895630 GSVIVG01030627001 7271486 7286368 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01031200001 1242325 1251135 GSVIVG01038225001 24472633 24476376 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01038225001 24472633 24476376 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01038225001 24472633 24476376 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01038225001 24472633 24476376 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01038225001 24472633 24476376 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01038225001 24472633 24476376 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01038225001 24472633 24476376 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01038225001 24472633 24476376 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01035828001 4710459 4715512 GSVIVG01022881001 18452410 18454770 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01019537001 1427739 1444597 GSVIVG01016446001 3821847 3838396 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01016446001 3821847 3838396 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01016446001 3821847 3838396 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01016446001 3821847 3838396 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01006100001 41492270 41492668 GSVIVG01028132001 4057889 4060032 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01025071001 4779879 4787376 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01025071001 4779879 4787376 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019715001 2660189 2662100 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01018405001 9606144 9606951 GSVIVG01015523001 4466615 4472538 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01015523001 4466615 4472538 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033953001 16361299 16380725 GSVIVG01032880001 23702632 23703602 GSVIVG01032422001 27240979 27246727 GSVIVG01028431001 7456848 7465834 GSVIVG01030481001 6043908 6045557 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01030481001 6043908 6045557 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with double-stranded RNA. IEA GO:0003725 double-stranded RNA binding GSVIVG01030481001 6043908 6045557 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt. IEA GO:0004525 ribonuclease III activity GSVIVG01014061001 1176 19554 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01014061001 1176 19554 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. IEA GO:0008081 phosphoric diester hydrolase activity GSVIVG01014061001 1176 19554 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01014061001 1176 19554 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. IEA GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GSVIVG01013353001 12555009 12556441 GSVIVG01030251001 9862159 9863030 GSVIVG01000186001 15976676 15982748 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01000186001 15976676 15982748 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01000186001 15976676 15982748 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01000186001 15976676 15982748 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01032143001 22209555 22221044 GSVIVG01027470001 16477804 16479937 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01007874001 8104283 8106302 GSVIVG01037250001 16907629 16910320 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01037250001 16907629 16910320 Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium. IEA GO:0005544 calcium-dependent phospholipid binding GSVIVG01032598001 28706702 28740422 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum. IEA GO:0003993 acid phosphatase activity GSVIVG01032598001 28706702 28740422 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01032598001 28706702 28740422 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01026220001 14304703 14306598 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026220001 14304703 14306598 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026220001 14304703 14306598 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01026220001 14304703 14306598 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01012096001 1515090 1528970 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012096001 1515090 1528970 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01007389001 923263 926555 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01010257001 18487515 18500361 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01010257001 18487515 18500361 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010257001 18487515 18500361 Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01003546001 14506356 14507958 GSVIVG01035473001 1554759 1557419 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01014874001 11030365 11030922 GSVIVG01010598001 16172929 16174043 GSVIVG01018716001 10658512 10661212 GSVIVG01023487001 11056371 11056666 GSVIVG01033007001 25028976 25030714 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01022215001 17551734 17556673 GSVIVG01022064001 16305666 16312973 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: UDP-glucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein = UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein. IEA GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity GSVIVG01017683001 2622991 2635488 GSVIVG01000898001 3689311 3696177 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01034542001 19674978 19675780 GSVIVG01016541001 2981236 2983190 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01016541001 2981236 2983190 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01020733001 2544006 2547117 GSVIVG01034267001 13695703 13699381 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016473001 3570901 3573648 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01016473001 3570901 3573648 GO:0007596 blood coagulation The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01016473001 3570901 3573648 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01016473001 3570901 3573648 GO:0007596 blood coagulation The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01016473001 3570901 3573648 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01016473001 3570901 3573648 GO:0007596 blood coagulation The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01016473001 3570901 3573648 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01016473001 3570901 3573648 GO:0007596 blood coagulation The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01016473001 3570901 3573648 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016473001 3570901 3573648 GO:0007596 blood coagulation The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008803001 2245947 2250187 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01008803001 2245947 2250187 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01008803001 2245947 2250187 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01008803001 2245947 2250187 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01008803001 2245947 2250187 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01008803001 2245947 2250187 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01008803001 2245947 2250187 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008803001 2245947 2250187 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034533001 19750076 19751858 GSVIVG01017629001 2141832 2142422 GSVIVG01013014001 10221814 10224480 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01035897001 5460208 5460736 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01023327001 19696122 19697534 GSVIVG01028877001 17881724 17898213 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01028877001 17881724 17898213 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01028877001 17881724 17898213 GO:0006433 prolyl-tRNA aminoacylation The process of coupling proline to prolyl-tRNA, catalyzed by prolyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01028877001 17881724 17898213 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01028877001 17881724 17898213 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01028877001 17881724 17898213 GO:0006433 prolyl-tRNA aminoacylation The process of coupling proline to prolyl-tRNA, catalyzed by prolyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01028877001 17881724 17898213 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro). IEA GO:0004827 proline-tRNA ligase activity GSVIVG01028877001 17881724 17898213 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro). IEA GO:0004827 proline-tRNA ligase activity GSVIVG01028877001 17881724 17898213 GO:0006433 prolyl-tRNA aminoacylation The process of coupling proline to prolyl-tRNA, catalyzed by prolyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro). IEA GO:0004827 proline-tRNA ligase activity GSVIVG01028877001 17881724 17898213 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028877001 17881724 17898213 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028877001 17881724 17898213 GO:0006433 prolyl-tRNA aminoacylation The process of coupling proline to prolyl-tRNA, catalyzed by prolyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018738001 20291207 20293244 GSVIVG01007234001 31001213 31002813 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). IEA GO:0003755 peptidyl-prolyl cis-trans isomerase activity GSVIVG01018815001 19637857 19646091 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01018815001 19637857 19646091 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01018815001 19637857 19646091 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01018815001 19637857 19646091 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01018815001 19637857 19646091 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. IEA GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity GSVIVG01018815001 19637857 19646091 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. IEA GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity GSVIVG01018815001 19637857 19646091 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018815001 19637857 19646091 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030074001 9605517 9611930 GSVIVG01019622001 2020339 2023481 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01037854001 7082071 7098157 GSVIVG01033115001 25857620 25858179 GSVIVG01028022001 3242981 3244699 GSVIVG01026235001 14539724 14540773 GSVIVG01012990001 10573744 10587530 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01012990001 10573744 10587530 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01012990001 10573744 10587530 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01012990001 10573744 10587530 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01012990001 10573744 10587530 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012990001 10573744 10587530 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020556001 4410441 4425457 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01020556001 4410441 4425457 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01020556001 4410441 4425457 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01020556001 4410441 4425457 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01020556001 4410441 4425457 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014094001 338323 344985 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01014094001 338323 344985 The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01008297001 3517941 3530407 GSVIVG01007420001 31706085 31707069 GSVIVG01004397001 38360479 38366705 GSVIVG01030574001 6849903 6851953 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines. IEA GO:0005542 folic acid binding GSVIVG01030574001 6849903 6851953 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01019563001 1637891 1640114 GSVIVG01008889001 3180624 3189934 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01007576001 11776048 11781289 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01007533001 12553282 12553743 GSVIVG01033317001 21562260 21568050 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. IEA GO:0008137 NADH dehydrogenase (ubiquinone) activity GSVIVG01033317001 21562260 21568050 GO:0042773 ATP synthesis coupled electron transport The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. IEA GO:0008137 NADH dehydrogenase (ubiquinone) activity GSVIVG01033317001 21562260 21568050 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. IEA GO:0008137 NADH dehydrogenase (ubiquinone) activity GSVIVG01033317001 21562260 21568050 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. IEA GO:0008137 NADH dehydrogenase (ubiquinone) activity GSVIVG01033317001 21562260 21568050 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01033317001 21562260 21568050 GO:0042773 ATP synthesis coupled electron transport The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01033317001 21562260 21568050 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01033317001 21562260 21568050 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01033317001 21562260 21568050 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01033317001 21562260 21568050 GO:0042773 ATP synthesis coupled electron transport The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01033317001 21562260 21568050 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01033317001 21562260 21568050 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01015781001 17433235 17434221 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01007772001 9199303 9201475 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01017838001 3929621 3935511 GSVIVG01008224001 4493690 4501284 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01008224001 4493690 4501284 The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01004281001 37939022 37942958 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01006669001 27349731 27350819 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01023841001 3050206 3052674 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01023841001 3050206 3052674 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01023841001 3050206 3052674 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01023841001 3050206 3052674 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01023841001 3050206 3052674 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01023841001 3050206 3052674 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01023841001 3050206 3052674 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01023841001 3050206 3052674 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01017635001 2173792 2174477 GSVIVG01033746001 18167205 18168821 GSVIVG01014524001 4799621 4801550 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01033484001 20339203 20340580 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01033484001 20339203 20340580 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01033484001 20339203 20340580 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01033484001 20339203 20340580 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01001895001 6896746 6897718 GSVIVG01034618001 14139494 14140796 GSVIVG01028199001 4559892 4563119 GSVIVG01003116001 7374050 7374866 GSVIVG01030232001 10158924 10176853 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025989001 26213032 26220576 GSVIVG01030330001 8774573 8776213 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals. IEA GO:0008519 ammonium transmembrane transporter activity GSVIVG01030330001 8774573 8776213 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals. IEA GO:0008519 ammonium transmembrane transporter activity GSVIVG01030330001 8774573 8776213 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals. IEA GO:0008519 ammonium transmembrane transporter activity GSVIVG01030330001 8774573 8776213 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals. IEA GO:0008519 ammonium transmembrane transporter activity GSVIVG01036543001 23255198 23256315 GSVIVG01033247001 22212685 22221515 GSVIVG01020163001 9542890 9555896 GSVIVG01027596001 15196650 15201155 GSVIVG01026467001 23072108 23108432 GSVIVG01023876001 2771959 2805318 GSVIVG01034468001 20839816 20855197 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005575 cellular_component The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01034468001 20839816 20855197 GO:0009451 RNA modification The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. IEA GO:0005575 cellular_component The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01034468001 20839816 20855197 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005575 cellular_component The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01034468001 20839816 20855197 GO:0009451 RNA modification The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. IEA GO:0005575 cellular_component The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01034468001 20839816 20855197 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005575 cellular_component The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together. IEA Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051539 4 iron, 4 sulfur cluster binding GSVIVG01034468001 20839816 20855197 GO:0009451 RNA modification The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. IEA GO:0005575 cellular_component The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together. IEA Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051539 4 iron, 4 sulfur cluster binding GSVIVG01009724001 10801758 10809741 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01009724001 10801758 10809741 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01011542001 12702814 12703038 GSVIVG01009946001 12710695 12716741 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01009946001 12710695 12716741 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01009946001 12710695 12716741 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009946001 12710695 12716741 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009946001 12710695 12716741 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01009946001 12710695 12716741 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01009946001 12710695 12716741 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01009946001 12710695 12716741 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01009946001 12710695 12716741 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01009946001 12710695 12716741 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01018079001 6284075 6299193 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01018079001 6284075 6299193 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018079001 6284075 6299193 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the reaction: ATP + pyruvate = ADP + phosphoenolpyruvate. IEA GO:0004743 pyruvate kinase activity GSVIVG01018079001 6284075 6299193 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Interacting selectively and non-covalently with potassium (K+) ions. IEA GO:0030955 potassium ion binding GSVIVG01011432001 29610843 29612253 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01011432001 29610843 29612253 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01010730001 21865161 21867431 GSVIVG01001582001 5540757 5541187 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01001582001 5540757 5541187 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015852001 18407105 18409640 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the reaction: pectin + n H2O = n methanol + pectate. IEA GO:0030599 pectinesterase activity GSVIVG01008367001 2801895 2818700 GO:0006659 phosphatidylserine biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine. IEA GSVIVG01031056001 21553355 21554075 GSVIVG01017370001 7473762 7476692 GSVIVG01007946001 7286222 7292038 GSVIVG01022584001 5482922 5485235 GO:0006635 fatty acid beta-oxidation A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Catalysis of the reaction: acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2. IEA GO:0003997 acyl-CoA oxidase activity GSVIVG01022584001 5482922 5485235 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Catalysis of the reaction: acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2. IEA GO:0003997 acyl-CoA oxidase activity GSVIVG01022584001 5482922 5485235 GO:0006635 fatty acid beta-oxidation A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GSVIVG01022584001 5482922 5485235 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GSVIVG01024802001 6835581 6840349 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GSVIVG01019858001 3894151 3895743 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01019858001 3894151 3895743 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01019858001 3894151 3895743 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01019858001 3894151 3895743 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01030631001 7305305 7311622 Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. IEA GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GSVIVG01019590001 1803177 1803783 GSVIVG01002530001 35221902 35224484 GSVIVG01007725001 9893078 9898404 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01007725001 9893078 9898404 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01019920001 4460708 4468028 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + methylthioadenosine. IEA GO:0016847 1-aminocyclopropane-1-carboxylate synthase activity GSVIVG01026445001 23591105 23592241 GSVIVG01004474001 38748615 38748939 GSVIVG01018406001 9585339 9605595 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01018406001 9585339 9605595 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate, driving the unwinding of the DNA helix. IEA GO:0004003 ATP-dependent DNA helicase activity GSVIVG01018406001 9585339 9605595 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021383001 4706008 4762410 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA GSVIVG01025972001 26433783 26458644 GSVIVG01020808001 1713828 1716944 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01020808001 1713828 1716944 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01020808001 1713828 1716944 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01020808001 1713828 1716944 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01031107001 2129795 2148385 GSVIVG01017976001 5228981 5252763 GSVIVG01002138001 33166344 33167965 GSVIVG01019769001 3162110 3184219 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019769001 3162110 3184219 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019769001 3162110 3184219 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019769001 3162110 3184219 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019769001 3162110 3184219 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019769001 3162110 3184219 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019769001 3162110 3184219 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019769001 3162110 3184219 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019769001 3162110 3184219 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019769001 3162110 3184219 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019769001 3162110 3184219 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019769001 3162110 3184219 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019769001 3162110 3184219 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01019769001 3162110 3184219 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01019769001 3162110 3184219 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01019769001 3162110 3184219 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01019769001 3162110 3184219 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01019769001 3162110 3184219 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01019769001 3162110 3184219 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01019769001 3162110 3184219 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01019769001 3162110 3184219 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01019769001 3162110 3184219 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01019769001 3162110 3184219 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01019769001 3162110 3184219 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01019769001 3162110 3184219 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient. IEA GO:0005261 cation channel activity GSVIVG01019769001 3162110 3184219 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient. IEA GO:0005261 cation channel activity GSVIVG01019769001 3162110 3184219 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient. IEA GO:0005261 cation channel activity GSVIVG01019769001 3162110 3184219 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient. IEA GO:0005261 cation channel activity GSVIVG01019769001 3162110 3184219 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient. IEA GO:0005261 cation channel activity GSVIVG01019769001 3162110 3184219 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient. IEA GO:0005261 cation channel activity GSVIVG01019769001 3162110 3184219 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient. IEA GO:0005261 cation channel activity GSVIVG01019769001 3162110 3184219 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient. IEA GO:0005261 cation channel activity GSVIVG01019769001 3162110 3184219 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient. IEA GO:0005261 cation channel activity GSVIVG01019769001 3162110 3184219 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient. IEA GO:0005261 cation channel activity GSVIVG01019769001 3162110 3184219 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient. IEA GO:0005261 cation channel activity GSVIVG01019769001 3162110 3184219 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient. IEA GO:0005261 cation channel activity GSVIVG01019769001 3162110 3184219 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01019769001 3162110 3184219 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01019769001 3162110 3184219 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01019769001 3162110 3184219 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01019769001 3162110 3184219 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01019769001 3162110 3184219 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01019769001 3162110 3184219 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01019769001 3162110 3184219 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01019769001 3162110 3184219 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01019769001 3162110 3184219 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01019769001 3162110 3184219 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01019769001 3162110 3184219 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01019769001 3162110 3184219 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019769001 3162110 3184219 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019769001 3162110 3184219 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019769001 3162110 3184219 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019769001 3162110 3184219 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019769001 3162110 3184219 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019769001 3162110 3184219 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019769001 3162110 3184219 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019769001 3162110 3184219 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019769001 3162110 3184219 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019769001 3162110 3184219 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019769001 3162110 3184219 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019769001 3162110 3184219 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01019769001 3162110 3184219 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01019769001 3162110 3184219 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01019769001 3162110 3184219 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01019769001 3162110 3184219 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01019769001 3162110 3184219 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01019769001 3162110 3184219 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01019769001 3162110 3184219 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01019769001 3162110 3184219 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01019769001 3162110 3184219 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01019769001 3162110 3184219 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01019769001 3162110 3184219 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01019769001 3162110 3184219 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01019769001 3162110 3184219 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01019769001 3162110 3184219 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01019769001 3162110 3184219 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01019769001 3162110 3184219 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01019769001 3162110 3184219 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01019769001 3162110 3184219 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01019769001 3162110 3184219 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01019769001 3162110 3184219 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01019769001 3162110 3184219 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01019769001 3162110 3184219 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01019769001 3162110 3184219 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01019769001 3162110 3184219 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01019769001 3162110 3184219 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01019769001 3162110 3184219 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01019769001 3162110 3184219 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01019769001 3162110 3184219 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01019769001 3162110 3184219 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01019769001 3162110 3184219 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01019769001 3162110 3184219 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01019769001 3162110 3184219 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01019769001 3162110 3184219 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01019769001 3162110 3184219 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01019769001 3162110 3184219 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01019769001 3162110 3184219 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01019769001 3162110 3184219 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01019769001 3162110 3184219 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01019769001 3162110 3184219 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01019769001 3162110 3184219 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01019769001 3162110 3184219 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01019769001 3162110 3184219 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01019769001 3162110 3184219 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01019769001 3162110 3184219 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01019769001 3162110 3184219 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01019769001 3162110 3184219 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01019769001 3162110 3184219 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01019769001 3162110 3184219 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01019769001 3162110 3184219 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01019769001 3162110 3184219 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01019769001 3162110 3184219 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01019769001 3162110 3184219 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01019769001 3162110 3184219 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01019769001 3162110 3184219 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01019769001 3162110 3184219 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01019769001 3162110 3184219 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01019769001 3162110 3184219 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01019769001 3162110 3184219 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01019769001 3162110 3184219 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01030550001 6652495 6655305 GSVIVG01006096001 41419564 41421314 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01006096001 41419564 41421314 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01006096001 41419564 41421314 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036775001 22721760 22727850 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. IEA GO:0004618 phosphoglycerate kinase activity GSVIVG01036775001 22721760 22727850 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01036775001 22721760 22727850 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01012661001 413837 414543 GSVIVG01037509001 12540330 12542531 GSVIVG01008121001 5620016 5627317 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01008121001 5620016 5627317 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01008121001 5620016 5627317 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008121001 5620016 5627317 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008121001 5620016 5627317 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01008121001 5620016 5627317 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01008121001 5620016 5627317 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01008121001 5620016 5627317 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01008121001 5620016 5627317 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01008121001 5620016 5627317 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01031158001 1637615 1640109 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01031158001 1637615 1640109 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01028174001 4416339 4418032 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01018162001 13742179 13744203 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01038161001 23995248 24005036 GSVIVG01014717001 8940759 8945632 GO:0006364 rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01014717001 8940759 8945632 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01014717001 8940759 8945632 GO:0006364 rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01014717001 8940759 8945632 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01014717001 8940759 8945632 GO:0006364 rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. IEA Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate. IEA GO:0008757 S-adenosylmethionine-dependent methyltransferase activity GSVIVG01014717001 8940759 8945632 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate. IEA GO:0008757 S-adenosylmethionine-dependent methyltransferase activity GSVIVG01015205001 1823192 1831180 GSVIVG01028597001 10425437 10425547 GSVIVG01030446001 5615239 5615622 GSVIVG01006643001 27246079 27246360 GSVIVG01022109001 16641499 16644428 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01022109001 16641499 16644428 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01017449001 8708514 8712146 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022820001 19061625 19063390 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032497001 27901769 27912173 GSVIVG01030838001 17327937 17347173 GO:0006014 D-ribose metabolic process The chemical reactions and pathways involving D-ribose (ribo-pentose). As beta-D-ribofuranose, D-ribose forms the glycose moiety of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12. IEA Catalysis of the reaction: ATP + adenosine = ADP + AMP. IEA GO:0004001 adenosine kinase activity GSVIVG01030838001 17327937 17347173 GO:0006166 purine ribonucleoside salvage Any process which produces a purine nucleoside from derivatives of it, without de novo synthesis. IEA Catalysis of the reaction: ATP + adenosine = ADP + AMP. IEA GO:0004001 adenosine kinase activity GSVIVG01030838001 17327937 17347173 GO:0006014 D-ribose metabolic process The chemical reactions and pathways involving D-ribose (ribo-pentose). As beta-D-ribofuranose, D-ribose forms the glycose moiety of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12. IEA Catalysis of the reaction: ATP + D-ribose = ADP + D-ribose 5-phosphate. IEA GO:0004747 ribokinase activity GSVIVG01030838001 17327937 17347173 GO:0006166 purine ribonucleoside salvage Any process which produces a purine nucleoside from derivatives of it, without de novo synthesis. IEA Catalysis of the reaction: ATP + D-ribose = ADP + D-ribose 5-phosphate. IEA GO:0004747 ribokinase activity GSVIVG01011642001 5660586 5662488 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01018122001 6744587 6749194 GSVIVG01023218001 20990898 20997413 Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01023218001 20990898 20997413 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01023218001 20990898 20997413 Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01028852001 18073809 18081913 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01014970001 13249350 13250137 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of potassium ions (K+) from one side of a membrane to the other. IEA GO:0015079 potassium ion transmembrane transporter activity GSVIVG01032619001 2162264 2164227 GO:0009813 flavonoid biosynthetic process The chemical reactions and pathways resulting in the formation of flavonoids, a group of phenolic derivatives containing a flavan skeleton. IEA Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. IEA GO:0016853 isomerase activity GSVIVG01032619001 2162264 2164227 GO:0042398 cellular amino acid derivative biosynthetic process The chemical reactions and pathways resulting in the formation of compounds derived from amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. IEA GO:0016853 isomerase activity GSVIVG01032619001 2162264 2164227 GO:0009813 flavonoid biosynthetic process The chemical reactions and pathways resulting in the formation of flavonoids, a group of phenolic derivatives containing a flavan skeleton. IEA The catalysis of certain rearrangements of a molecule to break or form a ring. IEA GO:0016872 intramolecular lyase activity GSVIVG01032619001 2162264 2164227 GO:0042398 cellular amino acid derivative biosynthetic process The chemical reactions and pathways resulting in the formation of compounds derived from amino acids, organic acids containing one or more amino substituents. IEA The catalysis of certain rearrangements of a molecule to break or form a ring. IEA GO:0016872 intramolecular lyase activity GSVIVG01032619001 2162264 2164227 GO:0009813 flavonoid biosynthetic process The chemical reactions and pathways resulting in the formation of flavonoids, a group of phenolic derivatives containing a flavan skeleton. IEA Catalysis of the reaction: a chalcone = a flavanone. IEA GO:0045430 chalcone isomerase activity GSVIVG01032619001 2162264 2164227 GO:0042398 cellular amino acid derivative biosynthetic process The chemical reactions and pathways resulting in the formation of compounds derived from amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the reaction: a chalcone = a flavanone. IEA GO:0045430 chalcone isomerase activity GSVIVG01021682001 9278873 9281720 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01021682001 9278873 9281720 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01021682001 9278873 9281720 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01021682001 9278873 9281720 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01021682001 9278873 9281720 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033902001 16861285 16864429 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01001093001 22603169 22607807 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01001093001 22603169 22607807 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01001093001 22603169 22607807 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0070469 respiratory chain The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01001093001 22603169 22607807 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01001093001 22603169 22607807 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01001093001 22603169 22607807 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0070469 respiratory chain The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01001093001 22603169 22607807 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01001093001 22603169 22607807 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01001093001 22603169 22607807 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0070469 respiratory chain The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01001093001 22603169 22607807 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+. IEA GO:0008121 ubiquinol-cytochrome-c reductase activity GSVIVG01001093001 22603169 22607807 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+. IEA GO:0008121 ubiquinol-cytochrome-c reductase activity GSVIVG01001093001 22603169 22607807 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0070469 respiratory chain The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+. IEA GO:0008121 ubiquinol-cytochrome-c reductase activity GSVIVG01001093001 22603169 22607807 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+. IEA GO:0008121 ubiquinol-cytochrome-c reductase activity GSVIVG01001093001 22603169 22607807 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+. IEA GO:0008121 ubiquinol-cytochrome-c reductase activity GSVIVG01001093001 22603169 22607807 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0070469 respiratory chain The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+. IEA GO:0008121 ubiquinol-cytochrome-c reductase activity GSVIVG01001093001 22603169 22607807 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+. IEA GO:0008121 ubiquinol-cytochrome-c reductase activity GSVIVG01001093001 22603169 22607807 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+. IEA GO:0008121 ubiquinol-cytochrome-c reductase activity GSVIVG01001093001 22603169 22607807 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0070469 respiratory chain The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+. IEA GO:0008121 ubiquinol-cytochrome-c reductase activity GSVIVG01001093001 22603169 22607807 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001093001 22603169 22607807 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001093001 22603169 22607807 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0070469 respiratory chain The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001093001 22603169 22607807 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001093001 22603169 22607807 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001093001 22603169 22607807 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0070469 respiratory chain The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001093001 22603169 22607807 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001093001 22603169 22607807 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001093001 22603169 22607807 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0070469 respiratory chain The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001093001 22603169 22607807 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of an oxidation-reduction (redox) reaction in which a diphenol or related substance acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016679 oxidoreductase activity, acting on diphenols and related substances as donors GSVIVG01001093001 22603169 22607807 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction in which a diphenol or related substance acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016679 oxidoreductase activity, acting on diphenols and related substances as donors GSVIVG01001093001 22603169 22607807 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0070469 respiratory chain The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. IEA Catalysis of an oxidation-reduction (redox) reaction in which a diphenol or related substance acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016679 oxidoreductase activity, acting on diphenols and related substances as donors GSVIVG01001093001 22603169 22607807 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of an oxidation-reduction (redox) reaction in which a diphenol or related substance acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016679 oxidoreductase activity, acting on diphenols and related substances as donors GSVIVG01001093001 22603169 22607807 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction in which a diphenol or related substance acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016679 oxidoreductase activity, acting on diphenols and related substances as donors GSVIVG01001093001 22603169 22607807 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0070469 respiratory chain The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. IEA Catalysis of an oxidation-reduction (redox) reaction in which a diphenol or related substance acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016679 oxidoreductase activity, acting on diphenols and related substances as donors GSVIVG01001093001 22603169 22607807 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of an oxidation-reduction (redox) reaction in which a diphenol or related substance acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016679 oxidoreductase activity, acting on diphenols and related substances as donors GSVIVG01001093001 22603169 22607807 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction in which a diphenol or related substance acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016679 oxidoreductase activity, acting on diphenols and related substances as donors GSVIVG01001093001 22603169 22607807 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0070469 respiratory chain The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. IEA Catalysis of an oxidation-reduction (redox) reaction in which a diphenol or related substance acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016679 oxidoreductase activity, acting on diphenols and related substances as donors GSVIVG01001093001 22603169 22607807 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01001093001 22603169 22607807 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01001093001 22603169 22607807 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0070469 respiratory chain The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01001093001 22603169 22607807 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01001093001 22603169 22607807 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01001093001 22603169 22607807 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0070469 respiratory chain The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01001093001 22603169 22607807 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01001093001 22603169 22607807 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01001093001 22603169 22607807 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0070469 respiratory chain The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01001093001 22603169 22607807 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01001093001 22603169 22607807 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01001093001 22603169 22607807 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0070469 respiratory chain The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01001093001 22603169 22607807 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01001093001 22603169 22607807 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01001093001 22603169 22607807 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0070469 respiratory chain The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01001093001 22603169 22607807 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01001093001 22603169 22607807 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01001093001 22603169 22607807 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0070469 respiratory chain The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01001093001 22603169 22607807 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051537 2 iron, 2 sulfur cluster binding GSVIVG01001093001 22603169 22607807 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051537 2 iron, 2 sulfur cluster binding GSVIVG01001093001 22603169 22607807 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0070469 respiratory chain The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. IEA Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051537 2 iron, 2 sulfur cluster binding GSVIVG01001093001 22603169 22607807 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051537 2 iron, 2 sulfur cluster binding GSVIVG01001093001 22603169 22607807 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051537 2 iron, 2 sulfur cluster binding GSVIVG01001093001 22603169 22607807 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0070469 respiratory chain The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. IEA Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051537 2 iron, 2 sulfur cluster binding GSVIVG01001093001 22603169 22607807 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051537 2 iron, 2 sulfur cluster binding GSVIVG01001093001 22603169 22607807 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051537 2 iron, 2 sulfur cluster binding GSVIVG01001093001 22603169 22607807 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0070469 respiratory chain The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. IEA Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051537 2 iron, 2 sulfur cluster binding GSVIVG01026734001 5843881 5846726 GSVIVG01032891001 23826909 23828426 GSVIVG01025706001 12808234 12809799 GSVIVG01016954001 2935552 2945817 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016954001 2935552 2945817 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016954001 2935552 2945817 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016954001 2935552 2945817 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Interacting selectively and non-covalently with damaged DNA. IEA GO:0003684 damaged DNA binding GSVIVG01016954001 2935552 2945817 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with damaged DNA. IEA GO:0003684 damaged DNA binding GSVIVG01016954001 2935552 2945817 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA Interacting selectively and non-covalently with damaged DNA. IEA GO:0003684 damaged DNA binding GSVIVG01016954001 2935552 2945817 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01016954001 2935552 2945817 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01016954001 2935552 2945817 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01016954001 2935552 2945817 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01016954001 2935552 2945817 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01016954001 2935552 2945817 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01016954001 2935552 2945817 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016954001 2935552 2945817 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016954001 2935552 2945817 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016954001 2935552 2945817 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01016954001 2935552 2945817 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01016954001 2935552 2945817 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01016954001 2935552 2945817 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01016954001 2935552 2945817 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01016954001 2935552 2945817 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01038091001 23407514 23410306 GSVIVG01028080001 3658148 3662106 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028080001 3658148 3662106 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). IEA GO:0016769 transferase activity, transferring nitrogenous groups GSVIVG01028080001 3658148 3662106 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01037020001 8828257 8831730 GSVIVG01022969001 17424024 17426843 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01022969001 17424024 17426843 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA A ligand-dependent receptor found in the nucleus of the cell. IEA GO:0004879 ligand-dependent nuclear receptor activity GSVIVG01029283001 17591728 17640205 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029283001 17591728 17640205 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029283001 17591728 17640205 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029283001 17591728 17640205 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029283001 17591728 17640205 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01029283001 17591728 17640205 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01029283001 17591728 17640205 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01029283001 17591728 17640205 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01029283001 17591728 17640205 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029283001 17591728 17640205 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029283001 17591728 17640205 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029283001 17591728 17640205 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029283001 17591728 17640205 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of calcium (Ca) ions from one side of a membrane to the other. IEA GO:0015085 calcium ion transmembrane transporter activity GSVIVG01029283001 17591728 17640205 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of calcium (Ca) ions from one side of a membrane to the other. IEA GO:0015085 calcium ion transmembrane transporter activity GSVIVG01029283001 17591728 17640205 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of calcium (Ca) ions from one side of a membrane to the other. IEA GO:0015085 calcium ion transmembrane transporter activity GSVIVG01029283001 17591728 17640205 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of calcium (Ca) ions from one side of a membrane to the other. IEA GO:0015085 calcium ion transmembrane transporter activity GSVIVG01029283001 17591728 17640205 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01029283001 17591728 17640205 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01029283001 17591728 17640205 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01029283001 17591728 17640205 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01029283001 17591728 17640205 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01029283001 17591728 17640205 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01029283001 17591728 17640205 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01029283001 17591728 17640205 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01011796001 4084591 4090555 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024470001 3057321 3063100 GSVIVG01018821001 19589675 19597480 Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01020485001 18679154 18679264 GSVIVG01000235001 20280188 20302163 GSVIVG01022011001 4330836 4334580 GSVIVG01033868001 17142119 17142496 GSVIVG01000736001 293473 295752 GSVIVG01003964001 26334936 26339106 GSVIVG01007763001 9300911 9306438 GSVIVG01023891001 2641395 2643174 GSVIVG01016919001 2571555 2574171 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01016919001 2571555 2574171 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016919001 2571555 2574171 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021396001 4878473 4890234 GSVIVG01013839001 5102506 5106639 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01013839001 5102506 5106639 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the reaction: pectin + n H2O = n methanol + pectate. IEA GO:0030599 pectinesterase activity GSVIVG01013839001 5102506 5106639 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue. IEA GO:0045330 aspartyl esterase activity GSVIVG01018756001 20147677 20163066 GSVIVG01024648001 8051860 8057999 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01024648001 8051860 8057999 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01024648001 8051860 8057999 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01024648001 8051860 8057999 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01024648001 8051860 8057999 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01024648001 8051860 8057999 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01024648001 8051860 8057999 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01024648001 8051860 8057999 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01024648001 8051860 8057999 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024648001 8051860 8057999 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028580001 10137662 10139202 GO:0019538 protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028580001 10137662 10139202 GO:0019538 protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01028580001 10137662 10139202 GO:0019538 protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01028580001 10137662 10139202 GO:0019538 protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01013344001 12454440 12460035 GSVIVG01035995001 6948586 6957422 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01035995001 6948586 6957422 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01035995001 6948586 6957422 GO:0009247 glycolipid biosynthetic process The chemical reactions and pathways resulting in the formation of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide). IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01035995001 6948586 6957422 GO:0030259 lipid glycosylation Covalent attachment of a glycosyl residue to a lipid molecule. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01035995001 6948586 6957422 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01035995001 6948586 6957422 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01035995001 6948586 6957422 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01035995001 6948586 6957422 GO:0009247 glycolipid biosynthetic process The chemical reactions and pathways resulting in the formation of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide). IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01035995001 6948586 6957422 GO:0030259 lipid glycosylation Covalent attachment of a glycosyl residue to a lipid molecule. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01035995001 6948586 6957422 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01035995001 6948586 6957422 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01035995001 6948586 6957422 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01035995001 6948586 6957422 GO:0009247 glycolipid biosynthetic process The chemical reactions and pathways resulting in the formation of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide). IEA Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01035995001 6948586 6957422 GO:0030259 lipid glycosylation Covalent attachment of a glycosyl residue to a lipid molecule. IEA Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01035995001 6948586 6957422 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01000233001 20183034 20211829 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000233001 20183034 20211829 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01030191001 10683310 10683967 GSVIVG01018404001 9607467 9631231 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01018404001 9607467 9631231 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate, driving the unwinding of the DNA helix. IEA GO:0004003 ATP-dependent DNA helicase activity GSVIVG01018404001 9607467 9631231 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026852001 19954690 19965367 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0009317 acetyl-CoA carboxylase complex A protein complex that catalyzes the first step in long-chain fatty acid biosynthesis. For example, in E. coli the complex is heterohexameric and composed of biotin carbonyl carrier protein, biotin carboxylase and the acetate CoA-transferase complex. IEA Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA. IEA GO:0003989 acetyl-CoA carboxylase activity GSVIVG01026852001 19954690 19965367 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0009317 acetyl-CoA carboxylase complex A protein complex that catalyzes the first step in long-chain fatty acid biosynthesis. For example, in E. coli the complex is heterohexameric and composed of biotin carbonyl carrier protein, biotin carboxylase and the acetate CoA-transferase complex. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01021292001 3581850 3586042 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014427001 3639943 3650257 GO:0032312 regulation of ARF GTPase activity Any process that modulates the activity of the GTPase ARF. IEA Increases the rate of GTP hydrolysis by the GTPase ARF. IEA GO:0008060 ARF GTPase activator activity GSVIVG01014427001 3639943 3650257 GO:0032312 regulation of ARF GTPase activity Any process that modulates the activity of the GTPase ARF. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01013194001 6879277 6882848 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013194001 6879277 6882848 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013194001 6879277 6882848 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01013194001 6879277 6882848 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01013194001 6879277 6882848 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01013194001 6879277 6882848 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01003828001 20475612 20476783 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: 3-alpha(S)-strictosidine = tryptamine + secologanin. IEA GO:0016844 strictosidine synthase activity GSVIVG01016798001 1487017 1492889 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01016043001 17810247 17810387 GSVIVG01007148001 5393507 5396372 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007148001 5393507 5396372 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007148001 5393507 5396372 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007148001 5393507 5396372 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007148001 5393507 5396372 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01007148001 5393507 5396372 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01007148001 5393507 5396372 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01007148001 5393507 5396372 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01007148001 5393507 5396372 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01007148001 5393507 5396372 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01007148001 5393507 5396372 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01007148001 5393507 5396372 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01007148001 5393507 5396372 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01007148001 5393507 5396372 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01007148001 5393507 5396372 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01007148001 5393507 5396372 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01000444001 8070650 8074229 GSVIVG01019195001 3725973 3727752 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01019195001 3725973 3727752 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01019195001 3725973 3727752 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026403001 15676483 15676833 GSVIVG01035847001 4838888 4840624 GSVIVG01021277001 3308084 3309197 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01001265001 4841365 4841723 GSVIVG01037262001 16772318 16772661 GSVIVG01008980001 4014840 4015257 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01008980001 4014840 4015257 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01032885001 23790128 23792131 GO:0015671 oxygen transport The directed movement of oxygen (O2) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01032885001 23790128 23792131 GO:0015671 oxygen transport The directed movement of oxygen (O2) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with oxygen (O2). IEA GO:0019825 oxygen binding GSVIVG01032885001 23790128 23792131 GO:0015671 oxygen transport The directed movement of oxygen (O2) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01014039001 9641691 9645484 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01014039001 9641691 9645484 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01038251001 24673706 24694003 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01038251001 24673706 24694003 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01038251001 24673706 24694003 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01038251001 24673706 24694003 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01038251001 24673706 24694003 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01038251001 24673706 24694003 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01032397001 26954397 26955677 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028920001 17534538 17540449 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01019463001 848928 850935 GO:0042318 penicillin biosynthetic process The chemical reactions and pathways resulting in the formation of any antibiotic that contains the condensed beta-lactamthiazolidine ring system. IEA GSVIVG01018928001 18579203 18592042 Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01032466001 27702554 27707121 GO:0015976 carbon utilization A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbon sources and then activates genes to scavenge the last traces of the primary carbon source and to transport and metabolize alternative carbon sources such as carbon dioxide or carbonic acid. The utilization process begins when the cell or organism detects carbon levels, includes the activation of genes whose products detect, transport or metabolize carbon-containing substances, and ends when carbon is incorporated into the cell or organism's metabolism. IEA Catalysis of the reaction: H2CO3 = CO2 + H2O. IEA GO:0004089 carbonate dehydratase activity GSVIVG01032466001 27702554 27707121 GO:0015976 carbon utilization A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbon sources and then activates genes to scavenge the last traces of the primary carbon source and to transport and metabolize alternative carbon sources such as carbon dioxide or carbonic acid. The utilization process begins when the cell or organism detects carbon levels, includes the activation of genes whose products detect, transport or metabolize carbon-containing substances, and ends when carbon is incorporated into the cell or organism's metabolism. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01032466001 27702554 27707121 GO:0015976 carbon utilization A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbon sources and then activates genes to scavenge the last traces of the primary carbon source and to transport and metabolize alternative carbon sources such as carbon dioxide or carbonic acid. The utilization process begins when the cell or organism detects carbon levels, includes the activation of genes whose products detect, transport or metabolize carbon-containing substances, and ends when carbon is incorporated into the cell or organism's metabolism. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01007838001 8541793 8543646 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01007838001 8541793 8543646 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01034688001 7726373 7726549 GSVIVG01008002001 6778789 6782640 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01036455001 22255076 22277284 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01036455001 22255076 22277284 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01038486001 10227598 10230155 GSVIVG01018242001 12687559 12688032 GSVIVG01011465001 29853967 29855166 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01011465001 29853967 29855166 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01037836001 7326029 7339940 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Interacting selectively and non-covalently with damaged DNA. IEA GO:0003684 damaged DNA binding GSVIVG01037836001 7326029 7339940 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and primer. IEA GO:0003887 DNA-directed DNA polymerase activity GSVIVG01003879001 13065448 13067066 GSVIVG01025195001 3463282 3486032 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01018638001 11851653 11853088 GSVIVG01019095001 16767618 16770353 GSVIVG01027010001 18584141 18590484 GSVIVG01032909001 23997438 24018763 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01032909001 23997438 24018763 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01020466001 18990270 19006513 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01020466001 18990270 19006513 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01020466001 18990270 19006513 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01020466001 18990270 19006513 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01035891001 5399282 5403785 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01035891001 5399282 5403785 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01027624001 14953797 14955411 GSVIVG01033522001 20037653 20042794 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01033522001 20037653 20042794 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01033522001 20037653 20042794 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01033522001 20037653 20042794 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033522001 20037653 20042794 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032276001 14372147 14372326 GSVIVG01029690001 13112038 13115305 GSVIVG01019654001 2239747 2248426 GO:0006357 regulation of transcription from RNA polymerase II promoter Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. IEA GO:0016592 mediator complex A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. IEA Functions to mediate the interaction of transcriptional activators with the RNA polymerase II-general RNA polymerase II transcription factor complex. IEA GO:0016455 RNA polymerase II transcription mediator activity GSVIVG01019654001 2239747 2248426 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA GO:0016592 mediator complex A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. IEA Functions to mediate the interaction of transcriptional activators with the RNA polymerase II-general RNA polymerase II transcription factor complex. IEA GO:0016455 RNA polymerase II transcription mediator activity GSVIVG01019654001 2239747 2248426 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA GO:0016592 mediator complex A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. IEA Functions to mediate the interaction of transcriptional activators with the RNA polymerase II-general RNA polymerase II transcription factor complex. IEA GO:0016455 RNA polymerase II transcription mediator activity GSVIVG01019654001 2239747 2248426 GO:0006357 regulation of transcription from RNA polymerase II promoter Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. IEA GO:0016592 mediator complex A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01019654001 2239747 2248426 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA GO:0016592 mediator complex A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01019654001 2239747 2248426 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA GO:0016592 mediator complex A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01021478001 5980915 5981675 GSVIVG01013843001 5134872 5142601 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004197 cysteine-type endopeptidase activity GSVIVG01004943001 21736728 21739613 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01004943001 21736728 21739613 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01023663001 8705144 8706413 GSVIVG01026526001 22273572 22279015 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01026526001 22273572 22279015 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01002270001 33817039 33819476 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01002270001 33817039 33819476 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01002270001 33817039 33819476 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01002270001 33817039 33819476 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01002270001 33817039 33819476 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01002270001 33817039 33819476 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01002270001 33817039 33819476 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01002270001 33817039 33819476 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01037466001 13221652 13245311 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01037466001 13221652 13245311 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01037466001 13221652 13245311 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01037466001 13221652 13245311 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01037466001 13221652 13245311 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01037466001 13221652 13245311 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01037466001 13221652 13245311 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01037466001 13221652 13245311 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01037466001 13221652 13245311 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01037466001 13221652 13245311 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01037466001 13221652 13245311 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01037466001 13221652 13245311 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01037466001 13221652 13245311 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01037466001 13221652 13245311 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01037466001 13221652 13245311 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01001645001 21698253 21703725 GSVIVG01037021001 8825459 8827504 GSVIVG01027075001 18151471 18156142 GSVIVG01000829001 2654994 2658006 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01000829001 2654994 2658006 Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium. IEA GO:0005544 calcium-dependent phospholipid binding GSVIVG01037830001 7415826 7415992 GSVIVG01018084001 6340890 6344320 GSVIVG01034489001 20503034 20524687 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01034489001 20503034 20524687 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01034489001 20503034 20524687 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01034489001 20503034 20524687 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01034489001 20503034 20524687 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033460001 20507193 20507334 GSVIVG01023098001 22660454 22669273 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01023098001 22660454 22669273 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01022058001 3573438 3596608 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005744 mitochondrial inner membrane presequence translocase complex The protein transport machinery of the mitochondrial inner membrane that contains three essential Tim proteins: Tim17 and Tim23 are thought to build a preprotein translocation channel while Tim44 interacts transiently with the matrix heat-shock protein Hsp70 to form an ATP-driven import motor. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01006305001 24767387 24771491 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01006305001 24767387 24771491 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01006305001 24767387 24771491 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01006305001 24767387 24771491 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01006305001 24767387 24771491 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01006305001 24767387 24771491 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01006305001 24767387 24771491 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01006305001 24767387 24771491 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01029389001 16030703 16074072 GSVIVG01027705001 14069022 14071752 GSVIVG01016765001 1161830 1162768 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01004067001 734720 734887 GSVIVG01027839001 8499367 8501424 GSVIVG01008294001 3553075 3561452 GSVIVG01019010001 17821355 17829046 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01019010001 17821355 17829046 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01019010001 17821355 17829046 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01019010001 17821355 17829046 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000401001 7534013 7535952 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01000401001 7534013 7535952 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01008810001 2336971 2345266 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: ATP + NAD+ = ADP + NADP+. IEA GO:0003951 NAD+ kinase activity GSVIVG01021239001 2888543 2893621 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01021239001 2888543 2893621 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01021239001 2888543 2893621 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01021239001 2888543 2893621 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016903001 2422109 2426052 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar. IEA GO:0008375 acetylglucosaminyltransferase activity GSVIVG01019441001 709707 709739 GSVIVG01018393001 9855961 9859805 GSVIVG01019848001 3821889 3822828 GSVIVG01018803001 19724027 19725390 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018803001 19724027 19725390 GO:0019673 GDP-mannose metabolic process The chemical reactions and pathways involving GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018803001 19724027 19725390 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018803001 19724027 19725390 GO:0045226 extracellular polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018803001 19724027 19725390 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01018803001 19724027 19725390 GO:0019673 GDP-mannose metabolic process The chemical reactions and pathways involving GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01018803001 19724027 19725390 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01018803001 19724027 19725390 GO:0045226 extracellular polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01018803001 19724027 19725390 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GDP-mannose = GDP-4-dehydro-6-deoxy-D-mannose + H2O. IEA GO:0008446 GDP-mannose 4,6-dehydratase activity GSVIVG01018803001 19724027 19725390 GO:0019673 GDP-mannose metabolic process The chemical reactions and pathways involving GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GDP-mannose = GDP-4-dehydro-6-deoxy-D-mannose + H2O. IEA GO:0008446 GDP-mannose 4,6-dehydratase activity GSVIVG01018803001 19724027 19725390 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GDP-mannose = GDP-4-dehydro-6-deoxy-D-mannose + H2O. IEA GO:0008446 GDP-mannose 4,6-dehydratase activity GSVIVG01018803001 19724027 19725390 GO:0045226 extracellular polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GDP-mannose = GDP-4-dehydro-6-deoxy-D-mannose + H2O. IEA GO:0008446 GDP-mannose 4,6-dehydratase activity GSVIVG01018803001 19724027 19725390 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + NADPH + H+. IEA GO:0008831 dTDP-4-dehydrorhamnose reductase activity GSVIVG01018803001 19724027 19725390 GO:0019673 GDP-mannose metabolic process The chemical reactions and pathways involving GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + NADPH + H+. IEA GO:0008831 dTDP-4-dehydrorhamnose reductase activity GSVIVG01018803001 19724027 19725390 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + NADPH + H+. IEA GO:0008831 dTDP-4-dehydrorhamnose reductase activity GSVIVG01018803001 19724027 19725390 GO:0045226 extracellular polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + NADPH + H+. IEA GO:0008831 dTDP-4-dehydrorhamnose reductase activity GSVIVG01018803001 19724027 19725390 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01018803001 19724027 19725390 GO:0019673 GDP-mannose metabolic process The chemical reactions and pathways involving GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01018803001 19724027 19725390 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01018803001 19724027 19725390 GO:0045226 extracellular polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01017892001 4441484 4442765 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01014206001 1470024 1477163 GO:0006099 tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01014206001 1470024 1477163 GO:0006099 tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. IEA Catalysis of the reaction: phosphate + oxaloacetate = H2O + phosphoenolpyruvate + CO2. IEA GO:0008964 phosphoenolpyruvate carboxylase activity GSVIVG01038489001 10239520 10241172 GSVIVG01007956001 7210718 7218050 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01007956001 7210718 7218050 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01007956001 7210718 7218050 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli. IEA GO:0004707 MAP kinase activity GSVIVG01007956001 7210718 7218050 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01007956001 7210718 7218050 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017237001 5785788 5788706 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01017237001 5785788 5788706 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01017237001 5785788 5788706 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01017237001 5785788 5788706 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01027754001 7417580 7444624 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01030338001 8591271 8622974 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025122001 4242089 4245228 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01029213001 18463009 18469738 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01029213001 18463009 18469738 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0010181 FMN binding GSVIVG01029213001 18463009 18469738 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008509001 1252340 1260721 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01008509001 1252340 1260721 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01008509001 1252340 1260721 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01008509001 1252340 1260721 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01008509001 1252340 1260721 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032577001 28498072 28532256 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01032577001 28498072 28532256 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01032577001 28498072 28532256 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032577001 28498072 28532256 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032577001 28498072 28532256 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01032577001 28498072 28532256 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01032577001 28498072 28532256 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01032577001 28498072 28532256 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01032577001 28498072 28532256 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01032577001 28498072 28532256 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01026283001 15550538 15561858 GSVIVG01014068001 75853 77852 GSVIVG01021564001 7138487 7138645 GSVIVG01001969001 5891333 5892292 GSVIVG01016163001 7258773 7279760 GSVIVG01013264001 6092736 6112317 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01013264001 6092736 6112317 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01013264001 6092736 6112317 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01013264001 6092736 6112317 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01013264001 6092736 6112317 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01013264001 6092736 6112317 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01013264001 6092736 6112317 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013264001 6092736 6112317 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013264001 6092736 6112317 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01013264001 6092736 6112317 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01013264001 6092736 6112317 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0008236 serine-type peptidase activity GSVIVG01013264001 6092736 6112317 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0008236 serine-type peptidase activity GSVIVG01013264001 6092736 6112317 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01013264001 6092736 6112317 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01013264001 6092736 6112317 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01013264001 6092736 6112317 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01013264001 6092736 6112317 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01013264001 6092736 6112317 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01034690001 7760025 7809938 GO:0016311 dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. IEA Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. IEA GO:0004725 protein tyrosine phosphatase activity GSVIVG01034690001 7760025 7809938 GO:0016311 dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. IEA Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. IEA GO:0016791 phosphatase activity GSVIVG01019454001 798757 804686 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01019454001 798757 804686 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01023773001 10913644 10915065 GO:0006631 fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Catalysis of the reaction: acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2. IEA GO:0003997 acyl-CoA oxidase activity GSVIVG01023773001 10913644 10915065 GO:0006635 fatty acid beta-oxidation A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Catalysis of the reaction: acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2. IEA GO:0003997 acyl-CoA oxidase activity GSVIVG01023773001 10913644 10915065 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Catalysis of the reaction: acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2. IEA GO:0003997 acyl-CoA oxidase activity GSVIVG01023773001 10913644 10915065 GO:0006631 fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01023773001 10913644 10915065 GO:0006635 fatty acid beta-oxidation A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01023773001 10913644 10915065 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01023773001 10913644 10915065 GO:0006631 fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GSVIVG01023773001 10913644 10915065 GO:0006635 fatty acid beta-oxidation A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GSVIVG01023773001 10913644 10915065 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GSVIVG01023773001 10913644 10915065 GO:0006631 fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01023773001 10913644 10915065 GO:0006635 fatty acid beta-oxidation A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01023773001 10913644 10915065 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01025530001 14279035 14282995 GSVIVG01011443001 29693817 29695173 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01011443001 29693817 29695173 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01031329001 327811 331186 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005764 lysosome A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01031329001 327811 331186 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA GO:0005764 lysosome A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01031329001 327811 331186 GO:0006665 sphingolipid metabolic process The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). IEA GO:0005764 lysosome A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01005680001 21174506 21176696 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01005680001 21174506 21176696 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01024677001 7865613 7867123 GSVIVG01023743001 10495568 10496780 GSVIVG01020705001 2965633 2973018 GO:0006099 tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01020705001 2965633 2973018 GO:0006099 tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. IEA Catalysis of the reaction: phosphate + oxaloacetate = H2O + phosphoenolpyruvate + CO2. IEA GO:0008964 phosphoenolpyruvate carboxylase activity GSVIVG01011059001 1896838 1924534 GSVIVG01027390001 15369916 15400809 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01027390001 15369916 15400809 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01027390001 15369916 15400809 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01014156001 909763 916258 GSVIVG01010687001 11799837 11800526 GSVIVG01003178001 5941804 5961856 GO:0016311 dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. IEA Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. IEA GO:0004725 protein tyrosine phosphatase activity GSVIVG01003178001 5941804 5961856 GO:0016311 dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. IEA Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. IEA GO:0016791 phosphatase activity GSVIVG01033400001 20953939 20960829 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01033400001 20953939 20960829 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01033400001 20953939 20960829 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01033400001 20953939 20960829 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037249001 16912618 16920281 GSVIVG01022153001 17025760 17030189 GSVIVG01006713001 27719169 27719318 GSVIVG01012841001 6010881 6016818 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: diphosphate + H2O = 2 phosphate. IEA GO:0004427 inorganic diphosphatase activity GSVIVG01012841001 6010881 6016818 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of pyrophosphate, which generates a proton motive force. IEA GO:0009678 hydrogen-translocating pyrophosphatase activity GSVIVG01037496001 12684861 12687577 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01037496001 12684861 12687577 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01033553001 19800883 19808234 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01033553001 19800883 19808234 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01033553001 19800883 19808234 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids. IEA GO:0004518 nuclease activity GSVIVG01033553001 19800883 19808234 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. IEA GO:0004519 endonuclease activity GSVIVG01010964001 2571672 2582070 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01031197001 1271227 1277962 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01031197001 1271227 1277962 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026487001 22814276 22820209 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01026487001 22814276 22820209 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01026487001 22814276 22820209 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01026487001 22814276 22820209 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009814001 11503598 11506380 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01032988001 24888099 24902171 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032988001 24888099 24902171 GO:0006013 mannose metabolic process The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032988001 24888099 24902171 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01032988001 24888099 24902171 GO:0006013 mannose metabolic process The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01032988001 24888099 24902171 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. IEA GO:0004559 alpha-mannosidase activity GSVIVG01032988001 24888099 24902171 GO:0006013 mannose metabolic process The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins. IEA Catalysis of the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. IEA GO:0004559 alpha-mannosidase activity GSVIVG01032988001 24888099 24902171 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01032988001 24888099 24902171 GO:0006013 mannose metabolic process The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01032988001 24888099 24902171 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of mannosyl compounds, substances containing a group derived from a cyclic form of mannose or a mannose derivative. IEA GO:0015923 mannosidase activity GSVIVG01032988001 24888099 24902171 GO:0006013 mannose metabolic process The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins. IEA Catalysis of the hydrolysis of mannosyl compounds, substances containing a group derived from a cyclic form of mannose or a mannose derivative. IEA GO:0015923 mannosidase activity GSVIVG01032988001 24888099 24902171 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01032988001 24888099 24902171 GO:0006013 mannose metabolic process The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins. IEA Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01037395001 14418825 14421330 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032626001 2085320 2085937 GSVIVG01030160001 11396186 11397609 GSVIVG01019404001 371214 372075 GSVIVG01027232001 17846226 17846729 GSVIVG01022501001 3973270 3987765 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01022501001 3973270 3987765 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01022501001 3973270 3987765 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015934 large ribosomal subunit The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01000179001 15920890 15944704 GSVIVG01001653001 13949519 13961249 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01001653001 13949519 13961249 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01001653001 13949519 13961249 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01001653001 13949519 13961249 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01001653001 13949519 13961249 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029963001 2406308 2407691 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01020704001 2982075 2982760 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01020704001 2982075 2982760 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01020704001 2982075 2982760 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01020704001 2982075 2982760 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01028980001 16921284 16925918 GSVIVG01010728001 21858900 21860381 GSVIVG01030054001 9274307 9276355 GSVIVG01006728001 27759191 27794027 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01006728001 27759191 27794027 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01006728001 27759191 27794027 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. IEA GO:0004563 beta-N-acetylhexosaminidase activity GSVIVG01006728001 27759191 27794027 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01027266001 17373215 17373256 GSVIVG01037150001 28596636 28597566 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01037150001 28596636 28597566 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019580001 1711563 1715073 GSVIVG01036184001 19713908 19723295 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01036184001 19713908 19723295 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036184001 19713908 19723295 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01036184001 19713908 19723295 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01034250001 13486128 13487484 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01022528001 4388885 4390027 GSVIVG01008581001 740806 743853 GSVIVG01017383001 7623898 7626075 GSVIVG01037947001 11395128 11395271 GSVIVG01020166001 9510816 9518104 GSVIVG01008291001 3581768 3583750 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019138001 16325051 16325705 GSVIVG01008461001 1736380 1773393 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008461001 1736380 1773393 GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008461001 1736380 1773393 GO:0006573 valine metabolic process The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008461001 1736380 1773393 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008461001 1736380 1773393 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008461001 1736380 1773393 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the reaction: D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate. IEA GO:0004332 fructose-bisphosphate aldolase activity GSVIVG01008461001 1736380 1773393 GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. IEA Catalysis of the reaction: D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate. IEA GO:0004332 fructose-bisphosphate aldolase activity GSVIVG01008461001 1736380 1773393 GO:0006573 valine metabolic process The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid. IEA Catalysis of the reaction: D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate. IEA GO:0004332 fructose-bisphosphate aldolase activity GSVIVG01008461001 1736380 1773393 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate. IEA GO:0004332 fructose-bisphosphate aldolase activity GSVIVG01008461001 1736380 1773393 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate. IEA GO:0004332 fructose-bisphosphate aldolase activity GSVIVG01008461001 1736380 1773393 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+. IEA GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity GSVIVG01008461001 1736380 1773393 GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. IEA Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+. IEA GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity GSVIVG01008461001 1736380 1773393 GO:0006573 valine metabolic process The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid. IEA Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+. IEA GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity GSVIVG01008461001 1736380 1773393 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+. IEA GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity GSVIVG01008461001 1736380 1773393 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+. IEA GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity GSVIVG01008461001 1736380 1773393 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008461001 1736380 1773393 GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008461001 1736380 1773393 GO:0006573 valine metabolic process The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008461001 1736380 1773393 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008461001 1736380 1773393 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008461001 1736380 1773393 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008461001 1736380 1773393 GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008461001 1736380 1773393 GO:0006573 valine metabolic process The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008461001 1736380 1773393 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008461001 1736380 1773393 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008461001 1736380 1773393 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the reaction: 3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH + H+. IEA GO:0008442 3-hydroxyisobutyrate dehydrogenase activity GSVIVG01008461001 1736380 1773393 GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. IEA Catalysis of the reaction: 3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH + H+. IEA GO:0008442 3-hydroxyisobutyrate dehydrogenase activity GSVIVG01008461001 1736380 1773393 GO:0006573 valine metabolic process The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid. IEA Catalysis of the reaction: 3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH + H+. IEA GO:0008442 3-hydroxyisobutyrate dehydrogenase activity GSVIVG01008461001 1736380 1773393 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH + H+. IEA GO:0008442 3-hydroxyisobutyrate dehydrogenase activity GSVIVG01008461001 1736380 1773393 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH + H+. IEA GO:0008442 3-hydroxyisobutyrate dehydrogenase activity GSVIVG01008461001 1736380 1773393 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008461001 1736380 1773393 GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008461001 1736380 1773393 GO:0006573 valine metabolic process The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008461001 1736380 1773393 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008461001 1736380 1773393 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008461001 1736380 1773393 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01008461001 1736380 1773393 GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01008461001 1736380 1773393 GO:0006573 valine metabolic process The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01008461001 1736380 1773393 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01008461001 1736380 1773393 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01003113001 7351862 7359676 GSVIVG01036914001 17728597 17733321 GSVIVG01026589001 21301124 21302040 GSVIVG01022104001 16607540 16613125 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01022104001 16607540 16613125 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01017334001 6834878 6836462 GSVIVG01000284001 2245750 2251431 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01000284001 2245750 2251431 Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium. IEA GO:0005544 calcium-dependent phospholipid binding GSVIVG01027309001 16872229 16872495 GSVIVG01013793001 7536464 7537993 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01013793001 7536464 7537993 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010330001 19565567 19569566 GSVIVG01029494001 22255626 22265771 GSVIVG01014318001 2599266 2600477 GSVIVG01031108001 2093877 2120417 GSVIVG01017053001 3809451 3816881 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01006526001 42869773 42870925 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01006526001 42869773 42870925 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014786001 9727791 9736298 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01010629001 15837589 15839249 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01010629001 15837589 15839249 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01018069001 6206914 6210538 GSVIVG01016761001 1126148 1126774 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with manganese (Mn) ions. IEA GO:0030145 manganese ion binding GSVIVG01016761001 1126148 1126774 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Functions in the storage of nutritious substrates. IEA GO:0045735 nutrient reservoir activity GSVIVG01016761001 1126148 1126774 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01007974001 7050696 7055235 GSVIVG01002106001 32969924 32973477 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01002106001 32969924 32973477 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01002106001 32969924 32973477 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01002106001 32969924 32973477 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01002106001 32969924 32973477 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01002106001 32969924 32973477 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01002106001 32969924 32973477 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01002106001 32969924 32973477 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01035775001 4193361 4196318 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01035775001 4193361 4196318 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01035775001 4193361 4196318 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and carries out proton transport across a membrane. The proton-transporting domain (F0, V0, or A0) includes integral and peripheral membrane proteins. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01035775001 4193361 4196318 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0033179 proton-transporting V-type ATPase, V0 domain A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01035775001 4193361 4196318 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01035775001 4193361 4196318 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01035775001 4193361 4196318 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and carries out proton transport across a membrane. The proton-transporting domain (F0, V0, or A0) includes integral and peripheral membrane proteins. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01035775001 4193361 4196318 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033179 proton-transporting V-type ATPase, V0 domain A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01035775001 4193361 4196318 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01035775001 4193361 4196318 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01035775001 4193361 4196318 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and carries out proton transport across a membrane. The proton-transporting domain (F0, V0, or A0) includes integral and peripheral membrane proteins. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01035775001 4193361 4196318 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033179 proton-transporting V-type ATPase, V0 domain A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01035775001 4193361 4196318 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01035775001 4193361 4196318 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01035775001 4193361 4196318 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and carries out proton transport across a membrane. The proton-transporting domain (F0, V0, or A0) includes integral and peripheral membrane proteins. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01035775001 4193361 4196318 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033179 proton-transporting V-type ATPase, V0 domain A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01035906001 5636703 5639632 GO:0005759 mitochondrial matrix The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. IEA GSVIVG01033549001 19839130 19841739 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01031492001 17978217 17980194 GO:0006730 one-carbon metabolic process The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. IEA Catalysis of the reaction: ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine. IEA GO:0004478 methionine adenosyltransferase activity GSVIVG01031492001 17978217 17980194 GO:0006730 one-carbon metabolic process The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015908001 19173481 19192428 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01015908001 19173481 19192428 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01020569001 4221428 4227355 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0016272 prefoldin complex A multisubunit chaperone that acts to delivers unfolded proteins to cytosolic chaperonin. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01019044001 17420699 17425264 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031017001 21000393 21005138 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: D-mannose 6-phosphate = D-fructose 6-phosphate. IEA GO:0004476 mannose-6-phosphate isomerase activity GSVIVG01031017001 21000393 21005138 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01001040001 6757784 6771069 GSVIVG01017016001 3471674 3472216 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017016001 3471674 3472216 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009418001 8196678 8199086 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01009418001 8196678 8199086 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01009418001 8196678 8199086 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01009418001 8196678 8199086 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009418001 8196678 8199086 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01014104001 434983 456680 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01014104001 434983 456680 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01014104001 434983 456680 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01037269001 16681873 16687232 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01037269001 16681873 16687232 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01013716001 8275280 8276291 GSVIVG01019476001 952858 960480 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01019476001 952858 960480 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01019476001 952858 960480 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019476001 952858 960480 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019476001 952858 960480 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01019476001 952858 960480 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01019476001 952858 960480 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01019476001 952858 960480 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01019476001 952858 960480 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01019476001 952858 960480 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01008956001 3832557 3832826 GSVIVG01018949001 18430782 18437824 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01018949001 18430782 18437824 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01018949001 18430782 18437824 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01018949001 18430782 18437824 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01018949001 18430782 18437824 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01018949001 18430782 18437824 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01018949001 18430782 18437824 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01018949001 18430782 18437824 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01025515001 96179 97337 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01020344001 21026564 21027012 GSVIVG01010777001 22482002 22483571 GSVIVG01037444001 13638819 13645443 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01037444001 13638819 13645443 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01037444001 13638819 13645443 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01037444001 13638819 13645443 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01037444001 13638819 13645443 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01037444001 13638819 13645443 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01037444001 13638819 13645443 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01037444001 13638819 13645443 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01037444001 13638819 13645443 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01037444001 13638819 13645443 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01037444001 13638819 13645443 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01037444001 13638819 13645443 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01037444001 13638819 13645443 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037444001 13638819 13645443 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037444001 13638819 13645443 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037444001 13638819 13645443 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01037444001 13638819 13645443 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01037444001 13638819 13645443 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01005128001 18400457 18401880 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01005128001 18400457 18401880 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01005128001 18400457 18401880 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01005128001 18400457 18401880 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01005128001 18400457 18401880 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01005128001 18400457 18401880 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01005128001 18400457 18401880 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01005128001 18400457 18401880 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01005128001 18400457 18401880 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01005128001 18400457 18401880 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01005128001 18400457 18401880 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01005128001 18400457 18401880 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01005128001 18400457 18401880 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01005128001 18400457 18401880 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01005128001 18400457 18401880 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01005128001 18400457 18401880 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01005128001 18400457 18401880 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01005128001 18400457 18401880 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01029393001 16119131 16147753 GSVIVG01004084001 14677117 14684660 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01004084001 14677117 14684660 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). IEA GO:0016769 transferase activity, transferring nitrogenous groups GSVIVG01004084001 14677117 14684660 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + methylthioadenosine. IEA GO:0016847 1-aminocyclopropane-1-carboxylate synthase activity GSVIVG01004084001 14677117 14684660 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01023324001 19749932 19751723 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017675001 2539624 2542890 GO:0006730 one-carbon metabolic process The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. IEA Catalysis of the reaction: ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine. IEA GO:0004478 methionine adenosyltransferase activity GSVIVG01017675001 2539624 2542890 GO:0006730 one-carbon metabolic process The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026815001 20300677 20302418 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01026815001 20300677 20302418 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01014132001 657407 658074 GSVIVG01017781001 3432514 3443155 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01025775001 12030366 12031142 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA Catalysis of the reaction: isopentenyl diphosphate + tRNA = diphosphate + tRNA containing 6-isopentenyladenosine. IEA GO:0004811 tRNA isopentenyltransferase activity GSVIVG01025775001 12030366 12031142 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013385001 807455 809607 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035395001 982056 986881 GO:0006413 translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. IEA Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. IEA GO:0003743 translation initiation factor activity GSVIVG01023325001 19727867 19746047 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023325001 19727867 19746047 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023325001 19727867 19746047 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023325001 19727867 19746047 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023325001 19727867 19746047 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01023325001 19727867 19746047 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01023325001 19727867 19746047 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01023325001 19727867 19746047 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01023325001 19727867 19746047 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01023325001 19727867 19746047 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01023325001 19727867 19746047 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01023325001 19727867 19746047 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01023325001 19727867 19746047 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01023325001 19727867 19746047 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01023325001 19727867 19746047 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01023325001 19727867 19746047 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01023325001 19727867 19746047 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023325001 19727867 19746047 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023325001 19727867 19746047 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023325001 19727867 19746047 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023325001 19727867 19746047 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01023325001 19727867 19746047 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01023325001 19727867 19746047 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01023325001 19727867 19746047 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01023325001 19727867 19746047 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwinding of the DNA helix in the direction 3' to 5'. IEA GO:0043140 ATP-dependent 3'-5' DNA helicase activity GSVIVG01023325001 19727867 19746047 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwinding of the DNA helix in the direction 3' to 5'. IEA GO:0043140 ATP-dependent 3'-5' DNA helicase activity GSVIVG01023325001 19727867 19746047 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwinding of the DNA helix in the direction 3' to 5'. IEA GO:0043140 ATP-dependent 3'-5' DNA helicase activity GSVIVG01023325001 19727867 19746047 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwinding of the DNA helix in the direction 3' to 5'. IEA GO:0043140 ATP-dependent 3'-5' DNA helicase activity GSVIVG01019733001 2814262 2824023 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0008076 voltage-gated potassium channel complex A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01019733001 2814262 2824023 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01019733001 2814262 2824023 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01019733001 2814262 2824023 GO:0015746 citrate transport The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0008076 voltage-gated potassium channel complex A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01019733001 2814262 2824023 GO:0015746 citrate transport The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01019733001 2814262 2824023 GO:0015746 citrate transport The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01019733001 2814262 2824023 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0008076 voltage-gated potassium channel complex A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01019733001 2814262 2824023 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01019733001 2814262 2824023 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01019733001 2814262 2824023 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0008076 voltage-gated potassium channel complex A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01019733001 2814262 2824023 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01019733001 2814262 2824023 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01019733001 2814262 2824023 GO:0015746 citrate transport The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0008076 voltage-gated potassium channel complex A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01019733001 2814262 2824023 GO:0015746 citrate transport The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01019733001 2814262 2824023 GO:0015746 citrate transport The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01019733001 2814262 2824023 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0008076 voltage-gated potassium channel complex A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01019733001 2814262 2824023 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01019733001 2814262 2824023 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01019733001 2814262 2824023 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0008076 voltage-gated potassium channel complex A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. IEA Catalysis of the transfer of arsenite from one side of a membrane to the other. IEA GO:0015105 arsenite transmembrane transporter activity GSVIVG01019733001 2814262 2824023 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of arsenite from one side of a membrane to the other. IEA GO:0015105 arsenite transmembrane transporter activity GSVIVG01019733001 2814262 2824023 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of arsenite from one side of a membrane to the other. IEA GO:0015105 arsenite transmembrane transporter activity GSVIVG01019733001 2814262 2824023 GO:0015746 citrate transport The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0008076 voltage-gated potassium channel complex A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. IEA Catalysis of the transfer of arsenite from one side of a membrane to the other. IEA GO:0015105 arsenite transmembrane transporter activity GSVIVG01019733001 2814262 2824023 GO:0015746 citrate transport The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of arsenite from one side of a membrane to the other. IEA GO:0015105 arsenite transmembrane transporter activity GSVIVG01019733001 2814262 2824023 GO:0015746 citrate transport The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of arsenite from one side of a membrane to the other. IEA GO:0015105 arsenite transmembrane transporter activity GSVIVG01019733001 2814262 2824023 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0008076 voltage-gated potassium channel complex A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. IEA Catalysis of the transfer of arsenite from one side of a membrane to the other. IEA GO:0015105 arsenite transmembrane transporter activity GSVIVG01019733001 2814262 2824023 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of arsenite from one side of a membrane to the other. IEA GO:0015105 arsenite transmembrane transporter activity GSVIVG01019733001 2814262 2824023 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of arsenite from one side of a membrane to the other. IEA GO:0015105 arsenite transmembrane transporter activity GSVIVG01019733001 2814262 2824023 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0008076 voltage-gated potassium channel complex A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. IEA Catalysis of the transfer of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, from one side of the membrane to the other. IEA GO:0015137 citrate transmembrane transporter activity GSVIVG01019733001 2814262 2824023 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, from one side of the membrane to the other. IEA GO:0015137 citrate transmembrane transporter activity GSVIVG01019733001 2814262 2824023 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, from one side of the membrane to the other. IEA GO:0015137 citrate transmembrane transporter activity GSVIVG01019733001 2814262 2824023 GO:0015746 citrate transport The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0008076 voltage-gated potassium channel complex A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. IEA Catalysis of the transfer of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, from one side of the membrane to the other. IEA GO:0015137 citrate transmembrane transporter activity GSVIVG01019733001 2814262 2824023 GO:0015746 citrate transport The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, from one side of the membrane to the other. IEA GO:0015137 citrate transmembrane transporter activity GSVIVG01019733001 2814262 2824023 GO:0015746 citrate transport The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, from one side of the membrane to the other. IEA GO:0015137 citrate transmembrane transporter activity GSVIVG01019733001 2814262 2824023 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0008076 voltage-gated potassium channel complex A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. IEA Catalysis of the transfer of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, from one side of the membrane to the other. IEA GO:0015137 citrate transmembrane transporter activity GSVIVG01019733001 2814262 2824023 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, from one side of the membrane to the other. IEA GO:0015137 citrate transmembrane transporter activity GSVIVG01019733001 2814262 2824023 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, from one side of the membrane to the other. IEA GO:0015137 citrate transmembrane transporter activity GSVIVG01027992001 3049273 3052392 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01027992001 3049273 3052392 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01025159001 3879687 3888448 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025159001 3879687 3888448 GO:0009725 response to hormone stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025159001 3879687 3888448 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025159001 3879687 3888448 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01025159001 3879687 3888448 GO:0009725 response to hormone stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01025159001 3879687 3888448 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01013397001 727431 730939 GSVIVG01000875001 3079496 3079759 GSVIVG01005109001 18181653 18183854 GSVIVG01009614001 9896911 9897714 GSVIVG01009721001 10782941 10787106 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01009721001 10782941 10787106 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01009721001 10782941 10787106 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01009721001 10782941 10787106 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01009721001 10782941 10787106 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01009721001 10782941 10787106 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01013060001 8943009 8975937 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate. IEA GO:0004366 glycerol-3-phosphate O-acyltransferase activity GSVIVG01013060001 8943009 8975937 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01014150001 846312 864401 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014150001 846312 864401 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014150001 846312 864401 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014150001 846312 864401 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014150001 846312 864401 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022858001 18696832 18697588 GSVIVG01002111001 32993289 32998698 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GSVIVG01022577001 5357282 5359524 GSVIVG01010363001 19834919 19840992 GSVIVG01006143001 42071609 42072583 GSVIVG01021666001 8946177 8982146 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01021666001 8946177 8982146 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01021666001 8946177 8982146 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01006515001 42682851 42684925 GSVIVG01008667001 23971 30618 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008667001 23971 30618 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008667001 23971 30618 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008667001 23971 30618 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008667001 23971 30618 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01008667001 23971 30618 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01008667001 23971 30618 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01008667001 23971 30618 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01005614001 40887496 40887984 GSVIVG01004713001 15431299 15432246 GSVIVG01030058001 9316914 9325218 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01030058001 9316914 9325218 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01030058001 9316914 9325218 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01030058001 9316914 9325218 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01030058001 9316914 9325218 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01030058001 9316914 9325218 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01030058001 9316914 9325218 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01030058001 9316914 9325218 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01030058001 9316914 9325218 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01030058001 9316914 9325218 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01030058001 9316914 9325218 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01030058001 9316914 9325218 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01030058001 9316914 9325218 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01030058001 9316914 9325218 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01030058001 9316914 9325218 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01030058001 9316914 9325218 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01030058001 9316914 9325218 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01030058001 9316914 9325218 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01030058001 9316914 9325218 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01030058001 9316914 9325218 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01030058001 9316914 9325218 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030058001 9316914 9325218 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030058001 9316914 9325218 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030058001 9316914 9325218 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030058001 9316914 9325218 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030058001 9316914 9325218 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01030058001 9316914 9325218 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01030058001 9316914 9325218 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01030058001 9316914 9325218 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01030058001 9316914 9325218 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01029266001 17806339 17808766 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01014187001 1337604 1338174 GSVIVG01028317001 6067508 6068523 GSVIVG01016962001 2987336 3007327 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016962001 2987336 3007327 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016962001 2987336 3007327 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016962001 2987336 3007327 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016962001 2987336 3007327 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016962001 2987336 3007327 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016962001 2987336 3007327 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01016962001 2987336 3007327 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01005063001 17813419 17815009 GSVIVG01006665001 27323067 27323372 GSVIVG01016308001 5296887 5298182 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033674001 18768420 18771398 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033674001 18768420 18771398 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01026952001 19083546 19097009 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01026952001 19083546 19097009 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01026952001 19083546 19097009 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01026952001 19083546 19097009 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026952001 19083546 19097009 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. IEA GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GSVIVG01025371001 1347067 1350208 GSVIVG01013967001 8081748 8134681 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01012900001 6653566 6682777 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01000209001 16105485 16106369 GSVIVG01029859001 627163 629682 GSVIVG01023496001 10955760 10956570 GSVIVG01033288001 21784498 21787274 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01033288001 21784498 21787274 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01033288001 21784498 21787274 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01033288001 21784498 21787274 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033288001 21784498 21787274 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003326001 9073394 9078605 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01003326001 9073394 9078605 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01003326001 9073394 9078605 GO:0015746 citrate transport The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01003326001 9073394 9078605 GO:0015746 citrate transport The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01003326001 9073394 9078605 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01003326001 9073394 9078605 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01003326001 9073394 9078605 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, from one side of the membrane to the other. IEA GO:0015137 citrate transmembrane transporter activity GSVIVG01003326001 9073394 9078605 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, from one side of the membrane to the other. IEA GO:0015137 citrate transmembrane transporter activity GSVIVG01003326001 9073394 9078605 GO:0015746 citrate transport The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, from one side of the membrane to the other. IEA GO:0015137 citrate transmembrane transporter activity GSVIVG01003326001 9073394 9078605 GO:0015746 citrate transport The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, from one side of the membrane to the other. IEA GO:0015137 citrate transmembrane transporter activity GSVIVG01003326001 9073394 9078605 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, from one side of the membrane to the other. IEA GO:0015137 citrate transmembrane transporter activity GSVIVG01003326001 9073394 9078605 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, from one side of the membrane to the other. IEA GO:0015137 citrate transmembrane transporter activity GSVIVG01037868001 6923378 6930220 GSVIVG01020797001 1854164 1886313 GSVIVG01014238001 1809114 1811504 GSVIVG01032870001 101740 106579 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. IEA GO:0008080 N-acetyltransferase activity GSVIVG01019173001 4134743 4135927 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019173001 4134743 4135927 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01036271001 7682304 7686341 GSVIVG01024807001 6799970 6806465 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01024807001 6799970 6806465 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01024807001 6799970 6806465 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01009840001 11726572 11729535 GSVIVG01009756001 11018628 11019094 GSVIVG01029265001 17821900 17823266 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01029265001 17821900 17823266 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01026084001 24806056 24809727 GSVIVG01014369001 3098250 3107821 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01032335001 15146495 15180631 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01032335001 15146495 15180631 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01032335001 15146495 15180631 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01032335001 15146495 15180631 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032335001 15146495 15180631 Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01032335001 15146495 15180631 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01032055001 23164792 23167627 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01008020001 6616974 6623015 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01009971001 12941202 12948404 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01009971001 12941202 12948404 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01015710001 16159523 16162192 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01015710001 16159523 16162192 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01015710001 16159523 16162192 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015710001 16159523 16162192 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015710001 16159523 16162192 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01015710001 16159523 16162192 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01013576001 21109915 21114224 GSVIVG01035512001 1909484 1910022 GSVIVG01028346001 6400790 6403550 GO:0006353 transcription termination The process by which transcription is completed; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any activity that brings about termination of transcription. IEA GO:0003715 transcription termination factor activity GSVIVG01028346001 6400790 6403550 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any activity that brings about termination of transcription. IEA GO:0003715 transcription termination factor activity GSVIVG01028346001 6400790 6403550 GO:0006353 transcription termination The process by which transcription is completed; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028346001 6400790 6403550 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028346001 6400790 6403550 GO:0006353 transcription termination The process by which transcription is completed; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01028346001 6400790 6403550 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01027942001 9819374 9821392 GO:0016568 chromatin modification The alteration of DNA or protein in chromatin, which may result in changing the chromatin structure. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01027942001 9819374 9821392 GO:0016568 chromatin modification The alteration of DNA or protein in chromatin, which may result in changing the chromatin structure. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives. IEA GO:0018024 histone-lysine N-methyltransferase activity GSVIVG01028437001 7508694 7509266 GSVIVG01037435001 13799987 13801712 Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01037435001 13799987 13801712 Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01037435001 13799987 13801712 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01037435001 13799987 13801712 Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01033362001 21207239 21210593 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01033362001 21207239 21210593 GO:0007047 cellular cell wall organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01033362001 21207239 21210593 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01033362001 21207239 21210593 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01033362001 21207239 21210593 GO:0007047 cellular cell wall organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01033362001 21207239 21210593 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01033362001 21207239 21210593 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. IEA GO:0016791 phosphatase activity GSVIVG01033362001 21207239 21210593 GO:0007047 cellular cell wall organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. IEA Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. IEA GO:0016791 phosphatase activity GSVIVG01033362001 21207239 21210593 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. IEA GO:0016791 phosphatase activity GSVIVG01033362001 21207239 21210593 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01033362001 21207239 21210593 GO:0007047 cellular cell wall organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01033362001 21207239 21210593 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01036552001 23384136 23385107 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01036391001 4564392 4567572 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA GSVIVG01032147001 22119357 22120940 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01008433001 2109307 2134845 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008433001 2109307 2134845 Catalysis of the transfer of the amide nitrogen of glutamine to a variety of substrates. GATases catalyze two separate reactions at two active sites, which are located either on a single polypeptide chain or on different subunits. In the glutaminase reaction, glutamine is hydrolyzed to glutamate and ammonia, which is added to an acceptor substrate in the synthase reaction. IEA GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor GSVIVG01001706001 12485372 12485512 GSVIVG01016260001 5820447 5824348 GSVIVG01029154001 19026528 19030790 GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA GSVIVG01016477001 3534353 3534610 GSVIVG01038290001 25018224 25021287 GSVIVG01025981001 26355121 26358597 GSVIVG01035557001 2283623 2287194 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01035557001 2283623 2287194 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01035557001 2283623 2287194 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01018979001 18137893 18145402 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01018979001 18137893 18145402 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01018979001 18137893 18145402 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01018979001 18137893 18145402 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033759001 18056453 18058653 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01033759001 18056453 18058653 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01033759001 18056453 18058653 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01033759001 18056453 18058653 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01026967001 18948900 18953274 GO:0015940 pantothenate biosynthetic process The chemical reactions and pathways resulting in the formation of pantothenate, the anion of pantothenic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026967001 18948900 18953274 GO:0015940 pantothenate biosynthetic process The chemical reactions and pathways resulting in the formation of pantothenate, the anion of pantothenic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods. IEA Catalysis of the reaction: 5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate = tetrahydrofolate + 2-dehydropantoate. IEA GO:0003864 3-methyl-2-oxobutanoate hydroxymethyltransferase activity GSVIVG01018855001 19219490 19220055 GSVIVG01030858001 17769279 17855734 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030858001 17769279 17855734 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01030858001 17769279 17855734 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023679001 9048423 9048727 GSVIVG01020114001 10214817 10216764 GSVIVG01036167001 19892167 19895908 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01036167001 19892167 19895908 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01036167001 19892167 19895908 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01036167001 19892167 19895908 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01019615001 1969470 1970524 GSVIVG01028578001 10113415 10116734 GO:0015940 pantothenate biosynthetic process The chemical reactions and pathways resulting in the formation of pantothenate, the anion of pantothenic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods. IEA Catalysis of the reaction: ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate. IEA GO:0004592 pantoate-beta-alanine ligase activity GSVIVG01034137001 14901372 14905867 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01034137001 14901372 14905867 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01034137001 14901372 14905867 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01034137001 14901372 14905867 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01034137001 14901372 14905867 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01034137001 14901372 14905867 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033527001 19996866 20013989 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01015319001 2659289 2662827 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01003904001 13400158 13403845 GSVIVG01006298001 24726795 24731088 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01006298001 24726795 24731088 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01031578001 18409764 18411439 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01012259001 32355 36097 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. IEA GO:0016597 amino acid binding GSVIVG01018462001 14729817 14737730 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01018462001 14729817 14737730 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01018462001 14729817 14737730 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01018462001 14729817 14737730 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007963001 7124403 7126089 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01014990001 23502 34778 GSVIVG01012809001 5594298 5595027 GSVIVG01035849001 4844000 4845216 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01000071001 3215339 3216409 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with manganese (Mn) ions. IEA GO:0030145 manganese ion binding GSVIVG01000071001 3215339 3216409 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Functions in the storage of nutritious substrates. IEA GO:0045735 nutrient reservoir activity GSVIVG01000071001 3215339 3216409 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01021341001 4256750 4257528 GSVIVG01037758001 7622503 7624507 GSVIVG01012549001 1166823 1172773 GSVIVG01008527001 1085035 1089874 GSVIVG01028142001 4164455 4165675 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha1-adrenergic receptors; the activity involves transmitting the signal to the Gq alpha subunit of a heterotrimeric G protein. IEA GO:0004937 alpha1-adrenergic receptor activity GSVIVG01028142001 4164455 4165675 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha1-adrenergic receptors; the activity involves transmitting the signal to the Gq alpha subunit of a heterotrimeric G protein. IEA GO:0004937 alpha1-adrenergic receptor activity GSVIVG01028142001 4164455 4165675 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha1-adrenergic receptors; the activity involves transmitting the signal to the Gq alpha subunit of a heterotrimeric G protein. IEA GO:0004937 alpha1-adrenergic receptor activity GSVIVG01028142001 4164455 4165675 GO:0051260 protein homooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha1-adrenergic receptors; the activity involves transmitting the signal to the Gq alpha subunit of a heterotrimeric G protein. IEA GO:0004937 alpha1-adrenergic receptor activity GSVIVG01028142001 4164455 4165675 GO:0051260 protein homooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha1-adrenergic receptors; the activity involves transmitting the signal to the Gq alpha subunit of a heterotrimeric G protein. IEA GO:0004937 alpha1-adrenergic receptor activity GSVIVG01028142001 4164455 4165675 GO:0051260 protein homooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha1-adrenergic receptors; the activity involves transmitting the signal to the Gq alpha subunit of a heterotrimeric G protein. IEA GO:0004937 alpha1-adrenergic receptor activity GSVIVG01028142001 4164455 4165675 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01028142001 4164455 4165675 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01028142001 4164455 4165675 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01028142001 4164455 4165675 GO:0051260 protein homooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01028142001 4164455 4165675 GO:0051260 protein homooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01028142001 4164455 4165675 GO:0051260 protein homooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01020684001 3124271 3130203 GSVIVG01008406001 2388619 2393012 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01008406001 2388619 2393012 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01008406001 2388619 2393012 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01008406001 2388619 2393012 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01008406001 2388619 2393012 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008406001 2388619 2393012 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008406001 2388619 2393012 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01008406001 2388619 2393012 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01016104001 19020079 19038655 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016104001 19020079 19038655 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01027627001 14897266 14903449 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027627001 14897266 14903449 GO:0019877 diaminopimelate biosynthetic process The chemical reactions and pathways resulting in the formation of diaminopimelate, both as an intermediate in lysine biosynthesis and as a component (as meso-diaminopimelate) of the peptidoglycan of Gram-negative bacterial cell walls. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027627001 14897266 14903449 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: L-aspartate-4-semialdehyde + pyruvate = dihydrodipicolinate + 2 H2O. IEA GO:0008840 dihydrodipicolinate synthase activity GSVIVG01027627001 14897266 14903449 GO:0019877 diaminopimelate biosynthetic process The chemical reactions and pathways resulting in the formation of diaminopimelate, both as an intermediate in lysine biosynthesis and as a component (as meso-diaminopimelate) of the peptidoglycan of Gram-negative bacterial cell walls. IEA Catalysis of the reaction: L-aspartate-4-semialdehyde + pyruvate = dihydrodipicolinate + 2 H2O. IEA GO:0008840 dihydrodipicolinate synthase activity GSVIVG01027627001 14897266 14903449 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01027627001 14897266 14903449 GO:0019877 diaminopimelate biosynthetic process The chemical reactions and pathways resulting in the formation of diaminopimelate, both as an intermediate in lysine biosynthesis and as a component (as meso-diaminopimelate) of the peptidoglycan of Gram-negative bacterial cell walls. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01020431001 19539045 19540048 GSVIVG01017078001 4021016 4021502 GSVIVG01021457001 5598848 5601327 GSVIVG01009634001 10074527 10075917 GSVIVG01009407001 8069331 8072096 GSVIVG01013718001 8251529 8252874 GSVIVG01034332001 17936525 17954261 GSVIVG01015498001 4233549 4234708 GSVIVG01037803001 7759653 7762665 GSVIVG01009698001 10583930 10587905 GSVIVG01000074001 3245459 3268889 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008139001 5457738 5464643 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01008139001 5457738 5464643 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01035949001 6327029 6327610 GSVIVG01005961001 22979050 22984591 GSVIVG01015870001 18683770 18684164 GSVIVG01011675001 5320670 5323273 GSVIVG01038560001 21827672 21831491 GSVIVG01004130001 15158077 15161785 GSVIVG01035572001 2397246 2404845 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01035572001 2397246 2404845 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01035572001 2397246 2404845 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01035572001 2397246 2404845 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01035572001 2397246 2404845 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01035572001 2397246 2404845 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01035572001 2397246 2404845 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01035572001 2397246 2404845 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01035572001 2397246 2404845 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01035572001 2397246 2404845 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035572001 2397246 2404845 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035572001 2397246 2404845 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035572001 2397246 2404845 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01035572001 2397246 2404845 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01035572001 2397246 2404845 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01035572001 2397246 2404845 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage. IEA GO:0016209 antioxidant activity GSVIVG01035572001 2397246 2404845 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage. IEA GO:0016209 antioxidant activity GSVIVG01035572001 2397246 2404845 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage. IEA GO:0016209 antioxidant activity GSVIVG01035572001 2397246 2404845 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01035572001 2397246 2404845 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01035572001 2397246 2404845 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01020133001 9998976 10003925 GSVIVG01014446001 3858392 3858658 GSVIVG01036549001 23320331 23341234 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01036549001 23320331 23341234 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01036549001 23320331 23341234 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01036549001 23320331 23341234 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01036549001 23320331 23341234 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01036549001 23320331 23341234 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01036549001 23320331 23341234 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01036549001 23320331 23341234 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01036549001 23320331 23341234 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01024956001 5683032 5684428 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024956001 5683032 5684428 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024956001 5683032 5684428 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01024956001 5683032 5684428 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01024956001 5683032 5684428 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01024956001 5683032 5684428 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01024956001 5683032 5684428 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01024956001 5683032 5684428 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01024956001 5683032 5684428 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01024956001 5683032 5684428 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01023382001 19143603 19147732 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01023382001 19143603 19147732 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01023382001 19143603 19147732 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01023382001 19143603 19147732 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023382001 19143603 19147732 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000571001 6976808 6977762 GSVIVG01022152001 17010095 17012318 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA GSVIVG01022152001 17010095 17012318 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GSVIVG01009611001 9884660 9889936 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01009611001 9884660 9889936 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01009611001 9884660 9889936 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01009611001 9884660 9889936 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021761001 10721148 10732597 GSVIVG01018856001 19196640 19199888 GSVIVG01036171001 19851934 19857138 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01036171001 19851934 19857138 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01029224001 18358253 18361723 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01029224001 18358253 18361723 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01029224001 18358253 18361723 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01029224001 18358253 18361723 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037416001 14133581 14138528 GSVIVG01022051001 3679285 3679996 GSVIVG01008359001 2893561 2898013 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01008359001 2893561 2898013 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01008359001 2893561 2898013 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008359001 2893561 2898013 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023683001 9158743 9171405 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004185 serine-type carboxypeptidase activity GSVIVG01005045001 17670560 17675970 GSVIVG01007328001 31394495 31395800 GSVIVG01030260001 9783214 9785509 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01025698001 12874188 12876708 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01020152001 9764040 9764869 GSVIVG01013569001 21065720 21066532 GSVIVG01009213001 6278100 6282770 GO:0006367 transcription initiation from RNA polymerase II promoter A transcription initiation process that results in RNA synthesis by RNA polymerase II. IEA GO:0005672 transcription factor TFIIA complex A component of the transcription machinery of RNA Polymerase II. In humans, TFIIA is a heterotrimer composed of an alpha (P35), beta (P19) and gamma subunits (P12). IEA Functions to initiate or regulate RNA polymerase II transcription. IEA GO:0003702 RNA polymerase II transcription factor activity GSVIVG01012957001 11785462 11786162 GSVIVG01015231001 1984908 1987420 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. IEA GO:0016791 phosphatase activity GSVIVG01014019001 9040789 9047113 GSVIVG01011798001 4064495 4072882 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01033117001 25878161 25883317 GSVIVG01006094001 41396457 41397747 GSVIVG01021444001 5420618 5440749 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0016272 prefoldin complex A multisubunit chaperone that acts to delivers unfolded proteins to cytosolic chaperonin. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01013443001 420616 423710 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01013443001 420616 423710 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01013443001 420616 423710 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01013443001 420616 423710 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01027114001 17741122 17743552 GSVIVG01014632001 7977107 7983555 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01014632001 7977107 7983555 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01014632001 7977107 7983555 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014632001 7977107 7983555 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014632001 7977107 7983555 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01014632001 7977107 7983555 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01014632001 7977107 7983555 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01014632001 7977107 7983555 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01014632001 7977107 7983555 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01014632001 7977107 7983555 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01023832001 3116926 3136608 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01023832001 3116926 3136608 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016071001 18329459 18338253 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016071001 18329459 18338253 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016071001 18329459 18338253 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016071001 18329459 18338253 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016071001 18329459 18338253 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016071001 18329459 18338253 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016071001 18329459 18338253 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01016071001 18329459 18338253 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01016071001 18329459 18338253 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01016071001 18329459 18338253 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016071001 18329459 18338253 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016071001 18329459 18338253 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025870001 10966632 10972180 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025870001 10966632 10972180 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01025870001 10966632 10972180 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01025870001 10966632 10972180 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01025870001 10966632 10972180 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025870001 10966632 10972180 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017040001 3700720 3707942 GO:0042779 tRNA 3'-trailer cleavage Cleavage of the 3'-end of the pre-tRNA as part of the process of generating the mature 3'-end of the tRNA; may involve endonucleolytic or exonucleolytic cleavage, or both. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01017040001 3700720 3707942 GO:0042779 tRNA 3'-trailer cleavage Cleavage of the 3'-end of the pre-tRNA as part of the process of generating the mature 3'-end of the tRNA; may involve endonucleolytic or exonucleolytic cleavage, or both. IEA Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters. IEA GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters GSVIVG01025042001 5056470 5059371 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: GTP + 3 H2O = formate + 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine + diphosphate. IEA GO:0003935 GTP cyclohydrolase II activity GSVIVG01025042001 5056470 5059371 GO:0009231 riboflavin biosynthetic process The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). IEA Catalysis of the reaction: GTP + 3 H2O = formate + 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine + diphosphate. IEA GO:0003935 GTP cyclohydrolase II activity GSVIVG01025042001 5056470 5059371 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: ribulose-5-phosphate = 3,4-dihydroxy-2-butanone-4-phosphate + formate. IEA GO:0008686 3,4-dihydroxy-2-butanone-4-phosphate synthase activity GSVIVG01025042001 5056470 5059371 GO:0009231 riboflavin biosynthetic process The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). IEA Catalysis of the reaction: ribulose-5-phosphate = 3,4-dihydroxy-2-butanone-4-phosphate + formate. IEA GO:0008686 3,4-dihydroxy-2-butanone-4-phosphate synthase activity GSVIVG01017466001 8837557 8838738 GSVIVG01032854001 229214 235486 GSVIVG01033830001 17384205 17389238 GSVIVG01020584001 4004275 4005147 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01020584001 4004275 4005147 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01020584001 4004275 4005147 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01020584001 4004275 4005147 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01020584001 4004275 4005147 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01020584001 4004275 4005147 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01010341001 19632806 19637702 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003822001 20444701 20445124 GSVIVG01035568001 2369934 2373379 GSVIVG01026424001 23718054 23723233 GSVIVG01025191001 3531021 3548396 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GSVIVG01011427001 29568923 29572092 GSVIVG01007808001 8814032 8814648 GSVIVG01014726001 9008549 9009273 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GSVIVG01012179001 736946 738532 GSVIVG01036736001 23186037 23190813 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01007646001 10874999 10877438 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01007646001 10874999 10877438 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01007646001 10874999 10877438 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01007646001 10874999 10877438 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01007646001 10874999 10877438 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034914001 85362 86460 GSVIVG01016108001 19131227 19133522 GSVIVG01010452001 20714759 20734567 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01010452001 20714759 20734567 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01010452001 20714759 20734567 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01010452001 20714759 20734567 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01008264001 3823248 3831307 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01008264001 3823248 3831307 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01008264001 3823248 3831307 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01008264001 3823248 3831307 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01021434001 5295654 5301884 GSVIVG01007601001 11401980 11406344 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01007601001 11401980 11406344 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01026692001 4878697 4896719 GSVIVG01035528001 2033559 2054695 GSVIVG01026997001 18695079 18699178 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA GSVIVG01026997001 18695079 18699178 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01024984001 5507543 5513858 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01012061001 1716350 1724237 GSVIVG01000524001 13658613 13670444 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01000524001 13658613 13670444 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01000524001 13658613 13670444 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01000524001 13658613 13670444 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01033266001 22005989 22007547 GSVIVG01000461001 8196440 8210716 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01030911001 18872816 18881390 GSVIVG01005597001 40798670 40801670 GSVIVG01031387001 19254220 19255122 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01031387001 19254220 19255122 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01019508001 1208153 1209559 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01019508001 1208153 1209559 GO:0008037 cell recognition The process by which a cell in a multicellular organism interprets its surroundings. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01019508001 1208153 1209559 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01019508001 1208153 1209559 GO:0019058 viral infectious cycle A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01036565001 23525331 23527758 Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01017431001 8446262 8456872 GSVIVG01024813001 6672781 6678951 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01024813001 6672781 6678951 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01024813001 6672781 6678951 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01024813001 6672781 6678951 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01024813001 6672781 6678951 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01024813001 6672781 6678951 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01024813001 6672781 6678951 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01024813001 6672781 6678951 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01024813001 6672781 6678951 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01024813001 6672781 6678951 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024813001 6672781 6678951 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024813001 6672781 6678951 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024813001 6672781 6678951 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024813001 6672781 6678951 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024813001 6672781 6678951 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024813001 6672781 6678951 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024813001 6672781 6678951 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024813001 6672781 6678951 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025317001 2082239 2106871 GSVIVG01025169001 3784960 3793396 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025169001 3784960 3793396 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01035714001 3580616 3585025 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01035714001 3580616 3585025 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01035714001 3580616 3585025 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01035714001 3580616 3585025 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038699001 20848483 20851612 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01038699001 20848483 20851612 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01038699001 20848483 20851612 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01038699001 20848483 20851612 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01038699001 20848483 20851612 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024330001 1063880 1081270 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01024330001 1063880 1081270 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01024330001 1063880 1081270 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01016372001 4397319 4400966 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01016372001 4397319 4400966 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01016372001 4397319 4400966 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01016372001 4397319 4400966 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01016372001 4397319 4400966 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016372001 4397319 4400966 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01037607001 9604127 9611879 GSVIVG01000798001 237084 237777 GSVIVG01006776001 28328860 28332255 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01023779001 11037020 11041491 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01023779001 11037020 11041491 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023779001 11037020 11041491 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024253001 244880 261847 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01024253001 244880 261847 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01024253001 244880 261847 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024253001 244880 261847 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01024253001 244880 261847 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01002543001 35271321 35274398 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01002543001 35271321 35274398 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01002543001 35271321 35274398 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01002543001 35271321 35274398 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020545001 4624639 4634286 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020545001 4624639 4634286 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01035123001 1646055 1646805 GO:0007218 neuropeptide signaling pathway The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor. IEA GSVIVG01035123001 1646055 1646805 GO:0007268 synaptic transmission The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. IEA GSVIVG01034980001 658342 667959 GSVIVG01025580001 13909144 13912416 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025580001 13909144 13912416 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01025580001 13909144 13912416 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01018963001 18296443 18301052 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01031289001 593133 600887 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01031289001 593133 600887 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01031289001 593133 600887 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01031289001 593133 600887 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01031289001 593133 600887 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01031289001 593133 600887 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01026913001 19430035 19440282 GO:0006637 acyl-CoA metabolic process The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group. IEA Catalysis of the reaction: acyl-CoA + H2O = corresponding fatty acid + CoA. IEA GO:0016291 acyl-CoA thioesterase activity GSVIVG01011460001 29790641 29793461 GSVIVG01021533001 6726868 6731432 GSVIVG01011802001 4028201 4031264 GSVIVG01031951001 5641165 5655774 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01031951001 5641165 5655774 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01005523001 40570819 40571119 GSVIVG01021953001 5197010 5198508 GO:0006801 superoxide metabolic process The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01021953001 5197010 5198508 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01020020001 11489164 11496595 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01020020001 11489164 11496595 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015935 small ribosomal subunit The smaller of the two subunits of a ribosome. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01020020001 11489164 11496595 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01020020001 11489164 11496595 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015935 small ribosomal subunit The smaller of the two subunits of a ribosome. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01020020001 11489164 11496595 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ribosomal RNA. IEA GO:0019843 rRNA binding GSVIVG01020020001 11489164 11496595 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015935 small ribosomal subunit The smaller of the two subunits of a ribosome. IEA Interacting selectively and non-covalently with ribosomal RNA. IEA GO:0019843 rRNA binding GSVIVG01018847001 19328134 19343256 GSVIVG01012860001 6301690 6308813 GSVIVG01008399001 2475548 2490062 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0000159 protein phosphatase type 2A complex A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit. IEA Modulation of the activity of the enzyme protein phosphatase type 2A. IEA GO:0008601 protein phosphatase type 2A regulator activity GSVIVG01038796001 1131170 1148368 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010040001 13735971 13739523 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01010040001 13735971 13739523 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01010040001 13735971 13739523 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01010040001 13735971 13739523 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01010040001 13735971 13739523 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030813001 16488161 16526754 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA GSVIVG01030813001 16488161 16526754 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA GSVIVG01013070001 8765673 8766279 GSVIVG01012897001 6584507 6590529 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012897001 6584507 6590529 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012897001 6584507 6590529 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01012897001 6584507 6590529 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01012897001 6584507 6590529 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01012897001 6584507 6590529 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01010116001 15732427 15732945 GSVIVG01006460001 26159360 26160916 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01006460001 26159360 26160916 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01006460001 26159360 26160916 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01006460001 26159360 26160916 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01006460001 26159360 26160916 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01006460001 26159360 26160916 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01006460001 26159360 26160916 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01006460001 26159360 26160916 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01030175001 10836390 10837187 GSVIVG01035631001 2843591 2855506 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule. IEA GO:0000175 3'-5'-exoribonuclease activity GSVIVG01035631001 2843591 2855506 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01038618001 21441800 21447160 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01017304001 6539501 6541529 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01017304001 6539501 6541529 GO:0007047 cellular cell wall organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01017304001 6539501 6541529 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01017304001 6539501 6541529 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01017304001 6539501 6541529 GO:0007047 cellular cell wall organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01017304001 6539501 6541529 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01017304001 6539501 6541529 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01017304001 6539501 6541529 GO:0007047 cellular cell wall organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01017304001 6539501 6541529 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01024754001 7205213 7207069 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01024754001 7205213 7207069 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01024754001 7205213 7207069 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01024754001 7205213 7207069 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024754001 7205213 7207069 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01024754001 7205213 7207069 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01022657001 14183472 14191283 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01015291001 2439159 2441049 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01015291001 2439159 2441049 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01017377001 7544775 7545923 GSVIVG01000338001 11685127 11703195 GO:0006573 valine metabolic process The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid. IEA Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH + H+. IEA GO:0004491 methylmalonate-semialdehyde dehydrogenase (acylating) activity GSVIVG01000338001 11685127 11703195 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH + H+. IEA GO:0004491 methylmalonate-semialdehyde dehydrogenase (acylating) activity GSVIVG01000338001 11685127 11703195 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH + H+. IEA GO:0004491 methylmalonate-semialdehyde dehydrogenase (acylating) activity GSVIVG01000338001 11685127 11703195 GO:0006573 valine metabolic process The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01000338001 11685127 11703195 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01000338001 11685127 11703195 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01019116001 16608369 16610633 GSVIVG01010659001 15470366 15475373 GO:0001539 ciliary or flagellar motility Cell motility due to movement of cilia or flagella. IEA GO:0009428 bacterial-type flagellum basal body, distal rod, P ring One of the rings of the flagellar basal body; anchors the basal body to the peptidoglycan layer. Examples of this component are found in bacteria. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01010659001 15470366 15475373 GO:0001539 ciliary or flagellar motility Cell motility due to movement of cilia or flagella. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01005343001 39840362 39840709 GSVIVG01009534001 9117968 9130712 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GSVIVG01030477001 5995106 6008201 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01036872001 18395298 18399974 GSVIVG01031148001 1714011 1716102 GSVIVG01013825001 4903351 4904021 GSVIVG01000799001 238471 241326 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009654 oxygen evolving complex A complex, composed of a cluster of manganese, calcium and chloride ions bound to extrinsic proteins, that catalyzes the splitting of water to O2 and 4 H+. In cyanobacteria there are five extrinsic proteins in OEC (PsbO, PsbP-like, PsbQ-like, PsbU and PsbV), while in plants there are only three (PsbO, PsbP and PsbQ). IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01000799001 238471 241326 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0019898 extrinsic to membrane Loosely bound to one surface of a membrane, but not integrated into the hydrophobic region. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01018511001 14027781 14036451 GSVIVG01006483001 26417089 26417763 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01006483001 26417089 26417763 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01009426001 8258047 8264639 GSVIVG01023005001 17016078 17017505 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01001318001 5263175 5284039 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01006273001 24399834 24407823 GSVIVG01014962001 13044600 13046091 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. IEA GO:0004364 glutathione transferase activity GSVIVG01016770001 1194883 1203175 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0005669 transcription factor TFIID complex A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01016770001 1194883 1203175 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0005669 transcription factor TFIID complex A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters. IEA IEA GO:0016986 transcription initiation factor activity GSVIVG01013300001 1070611 1071163 GSVIVG01008907001 3309837 3311940 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01008907001 3309837 3311940 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01015278001 2348942 2351902 GSVIVG01030225001 10256567 10274742 GSVIVG01019433001 662067 666143 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019433001 662067 666143 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01019433001 662067 666143 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01018989001 18030230 18035626 GSVIVG01037270001 16678380 16680454 GSVIVG01030130001 10115645 10117857 GSVIVG01023847001 3008797 3024629 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01017889001 4385231 4406549 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017889001 4385231 4406549 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01032633001 2005584 2009957 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01032633001 2005584 2009957 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01032633001 2005584 2009957 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01013838001 5068577 5070069 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01013838001 5068577 5070069 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01013838001 5068577 5070069 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01013838001 5068577 5070069 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01013838001 5068577 5070069 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01013838001 5068577 5070069 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01013838001 5068577 5070069 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01013838001 5068577 5070069 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01013838001 5068577 5070069 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01013838001 5068577 5070069 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01013838001 5068577 5070069 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01013838001 5068577 5070069 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01013838001 5068577 5070069 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the reaction: pectin + n H2O = n methanol + pectate. IEA GO:0030599 pectinesterase activity GSVIVG01013838001 5068577 5070069 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: pectin + n H2O = n methanol + pectate. IEA GO:0030599 pectinesterase activity GSVIVG01013838001 5068577 5070069 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the reaction: pectin + n H2O = n methanol + pectate. IEA GO:0030599 pectinesterase activity GSVIVG01013838001 5068577 5070069 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: pectin + n H2O = n methanol + pectate. IEA GO:0030599 pectinesterase activity GSVIVG01013838001 5068577 5070069 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the reaction: pectin + n H2O = n methanol + pectate. IEA GO:0030599 pectinesterase activity GSVIVG01013838001 5068577 5070069 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: pectin + n H2O = n methanol + pectate. IEA GO:0030599 pectinesterase activity GSVIVG01013838001 5068577 5070069 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue. IEA GO:0045330 aspartyl esterase activity GSVIVG01013838001 5068577 5070069 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue. IEA GO:0045330 aspartyl esterase activity GSVIVG01013838001 5068577 5070069 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue. IEA GO:0045330 aspartyl esterase activity GSVIVG01013838001 5068577 5070069 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue. IEA GO:0045330 aspartyl esterase activity GSVIVG01013838001 5068577 5070069 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue. IEA GO:0045330 aspartyl esterase activity GSVIVG01013838001 5068577 5070069 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue. IEA GO:0045330 aspartyl esterase activity GSVIVG01004662001 39427597 39429116 GSVIVG01033018001 25090451 25093317 GSVIVG01008602001 502631 504861 GSVIVG01032682001 1570365 1573278 GO:0006869 lipid transport The directed movement of lipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Interacting selectively and non-covalently with a lipid. IEA GO:0008289 lipid binding GSVIVG01036073001 21030102 21030980 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. IEA GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GSVIVG01014041001 9892377 9893363 GSVIVG01023050001 16355533 16359764 GSVIVG01016258001 5848151 5852377 GSVIVG01034979001 648109 653215 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01034979001 648109 653215 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01034979001 648109 653215 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity. IEA GO:0004721 phosphoprotein phosphatase activity GSVIVG01034979001 648109 653215 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. IEA GO:0004722 protein serine/threonine phosphatase activity GSVIVG01034979001 648109 653215 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01034979001 648109 653215 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01028417001 7381444 7383451 GSVIVG01021859001 6419299 6420687 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0005839 proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. IEA Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. IEA GO:0004298 threonine-type endopeptidase activity GSVIVG01037018001 8842961 8844343 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01037018001 8842961 8844343 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01037018001 8842961 8844343 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01037018001 8842961 8844343 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01037018001 8842961 8844343 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01037018001 8842961 8844343 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01037018001 8842961 8844343 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01037018001 8842961 8844343 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01015510001 4334317 4334409 GSVIVG01029511001 22108558 22109535 GSVIVG01006588001 26860663 26862424 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01022222001 17627134 17630179 GSVIVG01003557001 14628608 14629058 GSVIVG01014076001 157111 163022 GO:0006014 D-ribose metabolic process The chemical reactions and pathways involving D-ribose (ribo-pentose). As beta-D-ribofuranose, D-ribose forms the glycose moiety of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12. IEA Catalysis of the reaction: ATP + D-ribose = ADP + D-ribose 5-phosphate. IEA GO:0004747 ribokinase activity GSVIVG01014076001 157111 163022 GO:0006014 D-ribose metabolic process The chemical reactions and pathways involving D-ribose (ribo-pentose). As beta-D-ribofuranose, D-ribose forms the glycose moiety of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01014076001 157111 163022 GO:0006014 D-ribose metabolic process The chemical reactions and pathways involving D-ribose (ribo-pentose). As beta-D-ribofuranose, D-ribose forms the glycose moiety of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01004508001 38899279 38902087 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01004508001 38899279 38902087 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01004508001 38899279 38902087 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01004508001 38899279 38902087 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01004508001 38899279 38902087 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01004508001 38899279 38902087 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01004508001 38899279 38902087 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01004508001 38899279 38902087 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01028579001 10116989 10123698 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01028579001 10116989 10123698 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01036252001 8030341 8039095 GSVIVG01029701001 13356301 13361148 GSVIVG01008524001 1100351 1115997 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01008524001 1100351 1115997 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008524001 1100351 1115997 Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01008524001 1100351 1115997 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01018732001 20321485 20326332 GO:0009073 aromatic amino acid family biosynthetic process The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: 3-deoxy-arabino-heptulosonate 7-phosphate = 3-dehydroquinate + phosphate. IEA GO:0003856 3-dehydroquinate synthase activity GSVIVG01008937001 3587965 3594834 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01007242001 31051405 31053065 GSVIVG01019041001 17456543 17465760 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01010242001 18163363 18172933 GSVIVG01024186001 510038 511819 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01024186001 510038 511819 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01024186001 510038 511819 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01024186001 510038 511819 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024186001 510038 511819 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01024186001 510038 511819 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01015726001 16433627 16441033 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01015726001 16433627 16441033 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01015726001 16433627 16441033 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01015726001 16433627 16441033 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01014828001 10267544 10270507 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with transfer RNA. IEA GO:0000049 tRNA binding GSVIVG01014828001 10267544 10270507 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe). IEA GO:0004826 phenylalanine-tRNA ligase activity GSVIVG01014828001 10267544 10270507 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016097001 18937900 18941360 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01016097001 18937900 18941360 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01030621001 7218575 7225588 GSVIVG01016251001 5908112 5921409 GSVIVG01035116001 1574359 1575136 GSVIVG01026888001 19638156 19643685 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01032653001 1795243 1798037 GSVIVG01006982001 29599774 29602810 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01006982001 29599774 29602810 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01006982001 29599774 29602810 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01006982001 29599774 29602810 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01006982001 29599774 29602810 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01006982001 29599774 29602810 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01006982001 29599774 29602810 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01006982001 29599774 29602810 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01006982001 29599774 29602810 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006982001 29599774 29602810 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006982001 29599774 29602810 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01006982001 29599774 29602810 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01018776001 20015677 20020532 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01018776001 20015677 20020532 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids. IEA GO:0004518 nuclease activity GSVIVG01018776001 20015677 20020532 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. IEA GO:0004519 endonuclease activity GSVIVG01037749001 7478514 7493598 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01037749001 7478514 7493598 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01037963001 11715577 11716256 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) The catalytic sector of the mitochondrial hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the mitochondrial inner membrane when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01037963001 11715577 11716256 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) The catalytic sector of the mitochondrial hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the mitochondrial inner membrane when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01011160001 7542247 7557341 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01011160001 7542247 7557341 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01004016001 1340753 1343441 GSVIVG01022545001 4597152 4600059 GSVIVG01010182001 16916997 16917977 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01025975001 26414512 26416346 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01025975001 26414512 26416346 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01025975001 26414512 26416346 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01025975001 26414512 26416346 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025975001 26414512 26416346 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01025975001 26414512 26416346 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01018450001 14940190 14955349 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01018450001 14940190 14955349 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01010451001 20711558 20712478 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01010451001 20711558 20712478 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01010451001 20711558 20712478 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015934 large ribosomal subunit The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01025422001 929216 934137 GSVIVG01007672001 10612824 10614033 GSVIVG01034102001 15129876 15142836 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016507001 3314110 3326941 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01016507001 3314110 3326941 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031950001 5627128 5638418 GSVIVG01027180001 17222354 17223855 GSVIVG01017540001 10196125 10197123 GSVIVG01037669001 6702167 6706645 GSVIVG01000107001 15325228 15327698 GSVIVG01034234001 13201088 13201353 GSVIVG01018218001 13101371 13117884 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01018218001 13101371 13117884 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01018218001 13101371 13117884 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01018218001 13101371 13117884 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001489001 5114901 5116573 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012993001 10508820 10511615 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012993001 10508820 10511615 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012993001 10508820 10511615 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012993001 10508820 10511615 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA A ligand-dependent receptor found in the nucleus of the cell. IEA GO:0004879 ligand-dependent nuclear receptor activity GSVIVG01012993001 10508820 10511615 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA A ligand-dependent receptor found in the nucleus of the cell. IEA GO:0004879 ligand-dependent nuclear receptor activity GSVIVG01012993001 10508820 10511615 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA A ligand-dependent receptor found in the nucleus of the cell. IEA GO:0004879 ligand-dependent nuclear receptor activity GSVIVG01012993001 10508820 10511615 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012993001 10508820 10511615 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012993001 10508820 10511615 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012993001 10508820 10511615 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012993001 10508820 10511615 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012993001 10508820 10511615 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007595001 11466273 11469716 GO:0006464 protein modification process The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). IEA Catalysis of the reaction: S-adenosyl-L-methionine + protein L-beta-aspartate = S-adenosyl-L-homocysteine + protein L-beta-aspartate methyl ester. IEA GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity GSVIVG01014257001 2061553 2065112 GSVIVG01019698001 2538267 2543503 GO:0006626 protein targeting to mitochondrion The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein. IEA GO:0042719 mitochondrial intermembrane space protein transporter complex Soluble complex of the mitochondrial intermembrane space composed of various combinations of small Tim proteins; acts as a protein transporter to guide proteins to the Tim22 complex for insertion into the mitochondrial inner membrane. IEA GSVIVG01019698001 2538267 2543503 GO:0045039 protein import into mitochondrial inner membrane The import of proteins into the mitochondria inner membrane. Inner membrane proteins are first imported into the matrix space where the matrix-targeting sequence is removed; how these proteins then are incorporated into the inner membrane is not known. IEA GO:0042719 mitochondrial intermembrane space protein transporter complex Soluble complex of the mitochondrial intermembrane space composed of various combinations of small Tim proteins; acts as a protein transporter to guide proteins to the Tim22 complex for insertion into the mitochondrial inner membrane. IEA GSVIVG01019108001 16695327 16700045 GSVIVG01037213001 27922457 27924085 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01037213001 27922457 27924085 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01037213001 27922457 27924085 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01027789001 7787811 7788943 GSVIVG01021423001 5177313 5178332 GSVIVG01025199001 3427975 3432516 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01025199001 3427975 3432516 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01025199001 3427975 3432516 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01011892001 3235341 3237805 GSVIVG01010261001 18557851 18558676 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01010261001 18557851 18558676 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01010261001 18557851 18558676 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01010261001 18557851 18558676 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01007810001 8792559 8793921 GSVIVG01006459001 26144016 26158872 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01006459001 26144016 26158872 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01006459001 26144016 26158872 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01006459001 26144016 26158872 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01006459001 26144016 26158872 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01006459001 26144016 26158872 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01006459001 26144016 26158872 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01006459001 26144016 26158872 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024083001 1263034 1274247 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01001898001 6919378 6924433 GSVIVG01016281001 5575928 5578876 GSVIVG01037677001 6778730 6779511 GSVIVG01032060001 23120189 23122869 GSVIVG01008714001 1420067 1429156 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008714001 1420067 1429156 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the endohydrolysis of 1,4-alpha-D-glucosidic linkages in polysaccharides containing three or more 1,4-alpha-linked D-glucose units. IEA GO:0004556 alpha-amylase activity GSVIVG01008714001 1420067 1429156 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01008714001 1420067 1429156 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01013079001 8632908 8634857 GO:0009072 aromatic amino acid family metabolic process The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). IEA Catalysis of the reaction: 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2. IEA GO:0003868 4-hydroxyphenylpyruvate dioxygenase activity GSVIVG01009705001 10646973 10650794 GSVIVG01007388001 915009 918812 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01007388001 915009 918812 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01036332001 3882142 3885955 Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01036332001 3882142 3885955 Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01029406001 16520372 16521511 GSVIVG01020781001 2054800 2057841 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01020781001 2054800 2057841 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01038547001 21971524 21974662 Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01017454001 8729353 8735350 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01017454001 8729353 8735350 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01017454001 8729353 8735350 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017454001 8729353 8735350 Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01017454001 8729353 8735350 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01017454001 8729353 8735350 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01008488001 1419221 1420253 GSVIVG01031172001 1522668 1535425 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01012567001 3715718 3719756 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01000561001 7066224 7070866 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01000561001 7066224 7070866 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01000561001 7066224 7070866 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01000561001 7066224 7070866 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034191001 14537424 14541282 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar. IEA GO:0008375 acetylglucosaminyltransferase activity GSVIVG01024420001 2343171 2364713 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01024420001 2343171 2364713 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01024420001 2343171 2364713 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01024420001 2343171 2364713 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01024420001 2343171 2364713 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01024420001 2343171 2364713 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01037292001 16348683 16363465 Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. IEA GO:0016853 isomerase activity GSVIVG01022946001 17725785 17726103 GSVIVG01017888001 4367947 4384254 GSVIVG01022694001 15143097 15143624 GSVIVG01029802001 15034828 15037495 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01025189001 3568686 3573580 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01009119001 5240689 5246884 GSVIVG01011856001 3531010 3533067 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01011856001 3531010 3533067 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01011856001 3531010 3533067 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01011856001 3531010 3533067 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01010679001 11506579 11510669 GSVIVG01029368001 15569452 15578036 GSVIVG01035394001 979131 981610 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035394001 979131 981610 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035394001 979131 981610 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035394001 979131 981610 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035394001 979131 981610 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01035394001 979131 981610 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01031765001 4207533 4210487 GO:0007050 cell cycle arrest The process by which the cell cycle is halted during one of the normal phases (G1, S, G2, M). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Stops, prevents or reduces the activity of a cyclin-dependent protein kinase. IEA GO:0004861 cyclin-dependent protein kinase inhibitor activity GSVIVG01018398001 9763052 9768588 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01018398001 9763052 9768588 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01018398001 9763052 9768588 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01018398001 9763052 9768588 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01024575001 8686648 8687855 GO:0006801 superoxide metabolic process The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species. IEA Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + H2O2. IEA GO:0004784 superoxide dismutase activity GSVIVG01024575001 8686648 8687855 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + H2O2. IEA GO:0004784 superoxide dismutase activity GSVIVG01024575001 8686648 8687855 GO:0006801 superoxide metabolic process The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01024575001 8686648 8687855 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01021028001 15069725 15086324 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01021028001 15069725 15086324 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end. IEA GO:0008408 3'-5' exonuclease activity GSVIVG01033538001 19876259 19877643 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033538001 19876259 19877643 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033538001 19876259 19877643 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01033538001 19876259 19877643 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01033538001 19876259 19877643 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01033538001 19876259 19877643 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01033538001 19876259 19877643 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01033538001 19876259 19877643 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01033538001 19876259 19877643 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01033538001 19876259 19877643 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01015124001 1205755 1213113 GO:0006559 L-phenylalanine catabolic process The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015124001 1205755 1213113 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015124001 1205755 1213113 GO:0006559 L-phenylalanine catabolic process The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of ammonia (NH3) to another substance via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. IEA GO:0016211 ammonia ligase activity GSVIVG01015124001 1205755 1213113 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of ammonia (NH3) to another substance via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. IEA GO:0016211 ammonia ligase activity GSVIVG01015124001 1205755 1213113 GO:0006559 L-phenylalanine catabolic process The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate. IEA GO:0016841 ammonia-lyase activity GSVIVG01015124001 1205755 1213113 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate. IEA GO:0016841 ammonia-lyase activity GSVIVG01027820001 8158983 8170034 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01030757001 15461354 15461822 GSVIVG01027730001 7238277 7299021 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01009434001 8334379 8336883 GSVIVG01001129001 22854790 22859753 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01037533001 11951270 11958015 GSVIVG01030609001 7147555 7148809 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012134001 1143948 1147736 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01012134001 1143948 1147736 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01030432001 5513199 5513456 GSVIVG01016203001 6641768 6659876 GO:0032968 positive regulation of RNA elongation from RNA polymerase II promoter Any process that activates or increases the frequency, rate or extent of RNA elongation, the extension of an RNA molecule after transcription initiation by the addition of ribonucleotides, catalyzed by RNA polymerase II. IEA Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule following transcription initiation. IEA GO:0003711 transcription elongation regulator activity GSVIVG01031305001 512428 517863 GSVIVG01037869001 6917799 6921320 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Interacting selectively and non-covalently with damaged DNA. IEA GO:0003684 damaged DNA binding GSVIVG01037869001 6917799 6921320 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and primer. IEA GO:0003887 DNA-directed DNA polymerase activity GSVIVG01036532001 23121142 23123350 GSVIVG01014969001 13247465 13248191 GSVIVG01000068001 3206061 3206879 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with manganese (Mn) ions. IEA GO:0030145 manganese ion binding GSVIVG01000068001 3206061 3206879 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Functions in the storage of nutritious substrates. IEA GO:0045735 nutrient reservoir activity GSVIVG01030077001 9627077 9631428 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01030077001 9627077 9631428 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01013147001 7572665 7574498 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01013147001 7572665 7574498 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01033127001 8025658 8030106 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01033127001 8025658 8030106 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01033127001 8025658 8030106 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01033127001 8025658 8030106 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01033127001 8025658 8030106 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01033127001 8025658 8030106 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01033127001 8025658 8030106 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01033127001 8025658 8030106 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01033127001 8025658 8030106 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01033127001 8025658 8030106 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01033127001 8025658 8030106 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01033127001 8025658 8030106 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01033127001 8025658 8030106 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01033127001 8025658 8030106 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01033127001 8025658 8030106 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01033127001 8025658 8030106 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01033127001 8025658 8030106 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01033127001 8025658 8030106 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01033127001 8025658 8030106 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033127001 8025658 8030106 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033127001 8025658 8030106 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033127001 8025658 8030106 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033127001 8025658 8030106 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033127001 8025658 8030106 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033127001 8025658 8030106 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033127001 8025658 8030106 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033127001 8025658 8030106 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033127001 8025658 8030106 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033127001 8025658 8030106 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033127001 8025658 8030106 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033127001 8025658 8030106 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033127001 8025658 8030106 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033127001 8025658 8030106 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033127001 8025658 8030106 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033127001 8025658 8030106 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033127001 8025658 8030106 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033127001 8025658 8030106 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01033127001 8025658 8030106 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01033127001 8025658 8030106 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01033127001 8025658 8030106 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01033127001 8025658 8030106 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01033127001 8025658 8030106 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01033127001 8025658 8030106 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01033127001 8025658 8030106 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01033127001 8025658 8030106 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01033127001 8025658 8030106 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01033127001 8025658 8030106 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01033127001 8025658 8030106 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01033127001 8025658 8030106 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01033127001 8025658 8030106 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01033127001 8025658 8030106 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01033127001 8025658 8030106 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01033127001 8025658 8030106 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01033127001 8025658 8030106 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01025089001 4593470 4599724 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025089001 4593470 4599724 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025089001 4593470 4599724 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025089001 4593470 4599724 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025089001 4593470 4599724 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01025089001 4593470 4599724 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01025089001 4593470 4599724 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025089001 4593470 4599724 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022634001 13919740 13921377 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01022634001 13919740 13921377 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01022634001 13919740 13921377 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01022634001 13919740 13921377 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01013764001 7813881 7823597 GO:0016226 iron-sulfur cluster assembly The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01013764001 7813881 7823597 GO:0016226 iron-sulfur cluster assembly The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01000663001 20532432 20536987 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000663001 20532432 20536987 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000663001 20532432 20536987 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000663001 20532432 20536987 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024495001 3328585 3334227 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035027001 986562 999557 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. IEA GO:0005516 calmodulin binding GSVIVG01035027001 986562 999557 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01025796001 11777899 11779639 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01025796001 11777899 11779639 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01025796001 11777899 11779639 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01025796001 11777899 11779639 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01020434001 19501041 19517554 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019700001 2559585 2561332 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01019700001 2559585 2561332 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01019700001 2559585 2561332 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01019700001 2559585 2561332 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01001440001 21021503 21036800 GSVIVG01026502001 22516462 22518881 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026502001 22516462 22518881 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01033580001 19589062 19590492 GSVIVG01034032001 15696938 15699400 GO:0032968 positive regulation of RNA elongation from RNA polymerase II promoter Any process that activates or increases the frequency, rate or extent of RNA elongation, the extension of an RNA molecule after transcription initiation by the addition of ribonucleotides, catalyzed by RNA polymerase II. IEA Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule following transcription initiation. IEA GO:0003711 transcription elongation regulator activity GSVIVG01012704001 842403 845378 GSVIVG01009449001 8470824 8472314 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01011014001 2201273 2205929 GSVIVG01018097001 6504184 6527319 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of the terminal 1,2-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2). IEA GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity GSVIVG01018097001 6504184 6527319 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01035605001 2647940 2649519 GSVIVG01033638001 19062236 19062754 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01018273001 12199244 12212554 GSVIVG01026548001 21972742 21972843 GSVIVG01017774001 3360724 3368187 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01017774001 3360724 3368187 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01017774001 3360724 3368187 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01014133001 661689 663430 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033480001 20364151 20367264 GSVIVG01004450001 38639449 38639850 GSVIVG01022532001 4444679 4445164 GSVIVG01011180001 7851780 7854004 GSVIVG01018005001 5407543 5409647 GSVIVG01026324001 13974672 13992439 GSVIVG01020478001 18785290 18790280 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01031229001 1034028 1037941 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01031229001 1034028 1037941 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01000309001 2863971 2864243 GSVIVG01023255001 20527034 20533456 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: bile acid(out) + Na+(out) = bile acid(in) + Na+(in). IEA GO:0008508 bile acid:sodium symporter activity GSVIVG01023277001 20218476 20220934 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01007614001 11202228 11204433 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01007614001 11202228 11204433 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01007614001 11202228 11204433 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01007614001 11202228 11204433 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01038008001 12438928 12440844 GSVIVG01035519001 1970579 1975867 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035519001 1970579 1975867 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01025482001 420761 424745 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018970001 18230193 18230728 GSVIVG01007202001 30784662 30798480 GSVIVG01035826001 4688897 4693404 GSVIVG01022935001 17815602 17816108 GSVIVG01013734001 8083562 8085999 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01013734001 8083562 8085999 GO:0009396 folic acid and derivative biosynthetic process The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01013734001 8083562 8085999 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01013734001 8083562 8085999 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate. IEA GO:0004156 dihydropteroate synthase activity GSVIVG01013734001 8083562 8085999 GO:0009396 folic acid and derivative biosynthetic process The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. IEA Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate. IEA GO:0004156 dihydropteroate synthase activity GSVIVG01013734001 8083562 8085999 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate. IEA GO:0004156 dihydropteroate synthase activity GSVIVG01013734001 8083562 8085999 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01013734001 8083562 8085999 GO:0009396 folic acid and derivative biosynthetic process The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01013734001 8083562 8085999 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01013734001 8083562 8085999 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01013734001 8083562 8085999 GO:0009396 folic acid and derivative biosynthetic process The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01013734001 8083562 8085999 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01013734001 8083562 8085999 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01013734001 8083562 8085999 GO:0009396 folic acid and derivative biosynthetic process The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01013734001 8083562 8085999 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01009250001 6649030 6651798 GO:0006796 phosphate metabolic process The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01009250001 6649030 6651798 GO:0006796 phosphate metabolic process The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: diphosphate + H2O = 2 phosphate. IEA GO:0004427 inorganic diphosphatase activity GSVIVG01009561001 9433352 9433845 GSVIVG01007993001 6831714 6832614 GSVIVG01001116001 22737931 22739007 GSVIVG01024893001 6203623 6205245 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024893001 6203623 6205245 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024893001 6203623 6205245 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024893001 6203623 6205245 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01024893001 6203623 6205245 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01024893001 6203623 6205245 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01024893001 6203623 6205245 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024893001 6203623 6205245 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024893001 6203623 6205245 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024893001 6203623 6205245 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01024893001 6203623 6205245 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01024893001 6203623 6205245 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01024893001 6203623 6205245 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024893001 6203623 6205245 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024893001 6203623 6205245 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01034480001 20663925 20667249 GSVIVG01014361001 3010026 3013653 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01014361001 3010026 3013653 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014361001 3010026 3013653 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01001824001 26101822 26112476 GSVIVG01027622001 14976787 14983146 GSVIVG01026454001 23373476 23378726 GSVIVG01015517001 4386362 4390881 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01015517001 4386362 4390881 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01015517001 4386362 4390881 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01015517001 4386362 4390881 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01015517001 4386362 4390881 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01015517001 4386362 4390881 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01015517001 4386362 4390881 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01015517001 4386362 4390881 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01015517001 4386362 4390881 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01001654001 13966224 13967049 GSVIVG01008519001 1152189 1164212 GO:0009116 nucleoside metabolic process The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine). IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008519001 1152189 1164212 GO:0009116 nucleoside metabolic process The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine). IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01023546001 9853098 9885695 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01033814001 17565186 17567607 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01033814001 17565186 17567607 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01033814001 17565186 17567607 GO:0006414 translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01033814001 17565186 17567607 GO:0006414 translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01026746001 6073242 6074220 GSVIVG01011424001 29550874 29557194 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01011424001 29550874 29557194 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid. IEA GO:0008378 galactosyltransferase activity GSVIVG01024849001 6491355 6493969 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. IEA GO:0004364 glutathione transferase activity GSVIVG01014333001 2723240 2724364 GSVIVG01031146001 1733705 1744766 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01025825001 11455514 11461492 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01011746001 4612430 4635979 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01011746001 4612430 4635979 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011746001 4612430 4635979 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: ATP + D-ribulose 5-phosphate = ADP + D-ribulose 1,5-bisphosphate. IEA GO:0008974 phosphoribulokinase activity GSVIVG01011746001 4612430 4635979 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01011746001 4612430 4635979 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01037374001 14817247 14821503 GO:0006414 translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. IEA GO:0005853 eukaryotic translation elongation factor 1 complex A multisubunit nucleotide exchange complex that binds GTP and aminoacyl-tRNAs, and catalyzes their codon-dependent placement at the A-site of the ribosome. In humans, the complex is composed of four subunits, alpha, beta, delta and gamma. IEA Functions in chain elongation during polypeptide synthesis at the ribosome. IEA GO:0003746 translation elongation factor activity GSVIVG01026536001 22138851 22138988 GSVIVG01003285001 14117507 14118163 GSVIVG01025634001 13441942 13448558 Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01026352001 14692222 14705180 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027783001 7681860 7682719 GSVIVG01021053001 14531098 14546195 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin. IEA GO:0004221 ubiquitin thiolesterase activity GSVIVG01016169001 7077044 7084405 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01016169001 7077044 7084405 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01013867001 5684825 5685459 GSVIVG01010642001 15675424 15679159 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010642001 15675424 15679159 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010642001 15675424 15679159 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01010642001 15675424 15679159 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01010642001 15675424 15679159 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01010642001 15675424 15679159 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01010642001 15675424 15679159 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01010642001 15675424 15679159 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01010642001 15675424 15679159 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01010642001 15675424 15679159 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01002463001 34875573 34875785 GSVIVG01004373001 38297288 38302622 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035894001 5421564 5424000 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032016001 23511845 23531457 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032016001 23511845 23531457 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01032016001 23511845 23531457 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01026897001 19589365 19591904 GO:0009231 riboflavin biosynthetic process The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026897001 19589365 19591904 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026897001 19589365 19591904 GO:0009231 riboflavin biosynthetic process The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01026897001 19589365 19591904 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01026897001 19589365 19591904 GO:0009231 riboflavin biosynthetic process The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). IEA Catalysis of the reaction: 5-amino-6-(5-phosphoribitylamino)uracil + NADP+ = 5-amino-6-(5-phosphoribosylamino)uracil + NADPH + H+. IEA GO:0008703 5-amino-6-(5-phosphoribosylamino)uracil reductase activity GSVIVG01026897001 19589365 19591904 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 5-amino-6-(5-phosphoribitylamino)uracil + NADP+ = 5-amino-6-(5-phosphoribosylamino)uracil + NADPH + H+. IEA GO:0008703 5-amino-6-(5-phosphoribosylamino)uracil reductase activity GSVIVG01026897001 19589365 19591904 GO:0009231 riboflavin biosynthetic process The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). IEA Catalysis of the reaction: 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine + H2O = 5-amino-6-(5-phosphoribosylamino)uracil + NH3. IEA GO:0008835 diaminohydroxyphosphoribosylaminopyrimidine deaminase activity GSVIVG01026897001 19589365 19591904 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine + H2O = 5-amino-6-(5-phosphoribosylamino)uracil + NH3. IEA GO:0008835 diaminohydroxyphosphoribosylaminopyrimidine deaminase activity GSVIVG01026897001 19589365 19591904 GO:0009231 riboflavin biosynthetic process The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01026897001 19589365 19591904 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01020812001 1682196 1691573 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01020812001 1682196 1691573 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01020812001 1682196 1691573 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01020812001 1682196 1691573 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01028272001 5156970 5167838 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004197 cysteine-type endopeptidase activity GSVIVG01028272001 5156970 5167838 GO:0050790 regulation of catalytic activity Any process that modulates the activity of an enzyme. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004197 cysteine-type endopeptidase activity GSVIVG01028272001 5156970 5167838 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01028272001 5156970 5167838 GO:0050790 regulation of catalytic activity Any process that modulates the activity of an enzyme. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01034125001 14998835 15000284 GO:0009611 response to wounding A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism. IEA Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme. IEA GO:0004867 serine-type endopeptidase inhibitor activity GSVIVG01034419001 16556697 16566825 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01027061001 18244259 18245636 GSVIVG01013360001 978347 983075 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004181 metallocarboxypeptidase activity GSVIVG01013360001 978347 983075 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01013442001 425430 432998 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005945 6-phosphofructokinase complex A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known. IEA Catalysis of the reaction: ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate. IEA GO:0003872 6-phosphofructokinase activity GSVIVG01013442001 425430 432998 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005945 6-phosphofructokinase complex A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013442001 425430 432998 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005945 6-phosphofructokinase complex A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known. IEA Catalysis of the reaction: fructose-6-phosphate + pyrophosphate = phosphate + fructose-1,6-bisphosphate. IEA GO:0047334 diphosphate-fructose-6-phosphate 1-phosphotransferase activity GSVIVG01021790001 7402850 7408589 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01021790001 7402850 7408589 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01021790001 7402850 7408589 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01021790001 7402850 7408589 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01008601001 507531 508662 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01028797001 18732035 18733702 GSVIVG01003728001 7448658 7453211 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0008236 serine-type peptidase activity GSVIVG01012769001 23538115 23547724 GSVIVG01003830001 20482534 20500673 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: 3-alpha(S)-strictosidine = tryptamine + secologanin. IEA GO:0016844 strictosidine synthase activity GSVIVG01029446001 22794456 22798060 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01004808001 71072 76119 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01004808001 71072 76119 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01004808001 71072 76119 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01004808001 71072 76119 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01004808001 71072 76119 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01004808001 71072 76119 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01004808001 71072 76119 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01004808001 71072 76119 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01003977001 26427663 26434060 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01003977001 26427663 26434060 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01003977001 26427663 26434060 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01000239001 20419753 20422924 GSVIVG01022036001 4023883 4025103 GSVIVG01001914001 7153743 7156337 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001914001 7153743 7156337 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001914001 7153743 7156337 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01001914001 7153743 7156337 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01001914001 7153743 7156337 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01001914001 7153743 7156337 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01001914001 7153743 7156337 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001914001 7153743 7156337 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001914001 7153743 7156337 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01001914001 7153743 7156337 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01001914001 7153743 7156337 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. IEA GO:0048037 cofactor binding GSVIVG01001914001 7153743 7156337 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. IEA GO:0048037 cofactor binding GSVIVG01031517001 17718238 17729710 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01031517001 17718238 17729710 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031517001 17718238 17729710 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031517001 17718238 17729710 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01031517001 17718238 17729710 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01031517001 17718238 17729710 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01031517001 17718238 17729710 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01027864001 8772707 8773778 GSVIVG01020864001 878934 881289 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01020864001 878934 881289 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01018312001 11250557 11257332 GO:0007021 tubulin complex assembly The aggregation and bonding together of alpha- and beta-tubulin to form a tubulin heterodimer. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01032045001 23242201 23254601 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01032045001 23242201 23254601 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01025149001 3975146 3979091 GSVIVG01005934001 22834441 22842707 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01005934001 22834441 22842707 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01032137001 22281156 22286733 GSVIVG01025291001 2403691 2403831 GSVIVG01025057001 4885438 4893750 GSVIVG01034255001 13588665 13601803 GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Functions to increase the rate of ATP hydrolysis. IEA GO:0001671 ATPase activator activity GSVIVG01034255001 13588665 13601803 GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport. IEA GO:0051087 chaperone binding GSVIVG01020916001 17246943 17250635 GSVIVG01009187001 5910176 5912901 The action of a molecule that contributes to the structural integrity of a cytoskeletal structure. IEA GO:0005200 structural constituent of cytoskeleton GSVIVG01018807001 19696477 19697718 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01018807001 19696477 19697718 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01006107001 41577078 41579025 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Prevents the dissociation of GDP from the small GTPase Rab, thereby preventing GTP from binding. IEA GO:0005093 Rab GDP-dissociation inhibitor activity GSVIVG01006107001 41577078 41579025 GO:0043087 regulation of GTPase activity Any process that modulates the rate of GTP hydrolysis by a GTPase. IEA Prevents the dissociation of GDP from the small GTPase Rab, thereby preventing GTP from binding. IEA GO:0005093 Rab GDP-dissociation inhibitor activity GSVIVG01017194001 5189938 5190775 GSVIVG01000152001 15683072 15688842 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01030583001 6891306 6897746 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01003986001 26487067 26489713 GSVIVG01004859001 141698 154258 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin. IEA GO:0004221 ubiquitin thiolesterase activity GSVIVG01025209001 3279865 3288449 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule. IEA GO:0000175 3'-5'-exoribonuclease activity GSVIVG01025209001 3279865 3288449 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01023834001 3104161 3112730 GSVIVG01014941001 12437324 12438413 GSVIVG01014254001 2035403 2044271 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014254001 2035403 2044271 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01001705001 12421540 12422888 GSVIVG01010513001 21240516 21262171 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01018781001 19929609 19931425 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01018781001 19929609 19931425 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01013534001 2484308 2493960 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01006140001 42056934 42057181 GSVIVG01012513001 357404 361732 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the removal of a phosphate group from phosphorylated myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol. IEA GO:0004437 inositol or phosphatidylinositol phosphatase activity GSVIVG01012513001 357404 361732 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3. IEA GO:0042578 phosphoric ester hydrolase activity GSVIVG01016686001 367341 369043 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01007657001 10773204 10775493 GSVIVG01030622001 7238557 7245826 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01030622001 7238557 7245826 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01032981001 24792503 24793876 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+. IEA GO:0008121 ubiquinol-cytochrome-c reductase activity GSVIVG01032981001 24792503 24793876 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction in which a diphenol or related substance acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016679 oxidoreductase activity, acting on diphenols and related substances as donors GSVIVG01032037001 23302026 23305724 GSVIVG01016093001 18797854 18803033 GSVIVG01012964001 11660108 11663331 GSVIVG01026431001 23656230 23670272 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01015348001 2867801 2873780 GO:0006306 DNA methylation The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01015348001 2867801 2873780 GO:0032259 methylation The process by which a methyl group is covalently attached to a molecule. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01015348001 2867801 2873780 GO:0006306 DNA methylation The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01015348001 2867801 2873780 GO:0032259 methylation The process by which a methyl group is covalently attached to a molecule. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01015348001 2867801 2873780 GO:0006306 DNA methylation The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01015348001 2867801 2873780 GO:0032259 methylation The process by which a methyl group is covalently attached to a molecule. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01015348001 2867801 2873780 GO:0006306 DNA methylation The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. IEA Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule. IEA GO:0008170 N-methyltransferase activity GSVIVG01015348001 2867801 2873780 GO:0032259 methylation The process by which a methyl group is covalently attached to a molecule. IEA Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule. IEA GO:0008170 N-methyltransferase activity GSVIVG01011900001 3167525 3170831 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01011900001 3167525 3170831 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01011900001 3167525 3170831 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01011900001 3167525 3170831 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01025660001 13189064 13189783 GSVIVG01015389001 3223952 3225296 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01015389001 3223952 3225296 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01015389001 3223952 3225296 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01014665001 8340947 8343320 GSVIVG01032952001 24545165 24555258 GSVIVG01027385001 15444112 15469444 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01027385001 15444112 15469444 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01027385001 15444112 15469444 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01016435001 3932789 3933535 GO:0006869 lipid transport The directed movement of lipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Interacting selectively and non-covalently with a lipid. IEA GO:0008289 lipid binding GSVIVG01031116001 2034878 2046506 Interacting selectively and non-covalently with acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group. IEA GO:0000062 acyl-CoA binding GSVIVG01031116001 2034878 2046506 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031116001 2034878 2046506 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01009335001 7523275 7526375 GSVIVG01020400001 20068745 20107437 GSVIVG01007833001 8589763 8592049 GSVIVG01018474001 14573430 14574154 GSVIVG01028402001 7204658 7209262 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01028402001 7204658 7209262 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01013422001 572034 577186 GSVIVG01037616001 6267287 6270231 GSVIVG01000758001 461592 479589 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01031404001 19041783 19047544 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01032731001 1205138 1205885 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01001941001 15074590 15079381 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01038620001 21420051 21423341 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01038620001 21420051 21423341 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01038620001 21420051 21423341 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01038620001 21420051 21423341 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01036597001 18888729 18928377 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01036597001 18888729 18928377 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01036597001 18888729 18928377 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with a ribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to ribose. IEA GO:0032549 ribonucleoside binding GSVIVG01006535001 43026244 43027793 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01006535001 43026244 43027793 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01006535001 43026244 43027793 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01027863001 8758143 8760014 GO:0009306 protein secretion The controlled release of proteins from a cell or group of cells. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01027863001 8758143 8760014 GO:0009306 protein secretion The controlled release of proteins from a cell or group of cells. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01027863001 8758143 8760014 GO:0051260 protein homooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01027863001 8758143 8760014 GO:0051260 protein homooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01015027001 552902 554801 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage. IEA GO:0016209 antioxidant activity GSVIVG01015027001 552902 554801 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01014615001 5735553 5737897 GSVIVG01004867001 16213508 16219082 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01004867001 16213508 16219082 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01004867001 16213508 16219082 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01004867001 16213508 16219082 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01004867001 16213508 16219082 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01004867001 16213508 16219082 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01004867001 16213508 16219082 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01004867001 16213508 16219082 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01004867001 16213508 16219082 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01004867001 16213508 16219082 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01004867001 16213508 16219082 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01004867001 16213508 16219082 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01004867001 16213508 16219082 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01004867001 16213508 16219082 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01004867001 16213508 16219082 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01004867001 16213508 16219082 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01004867001 16213508 16219082 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01004867001 16213508 16219082 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01004867001 16213508 16219082 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01004867001 16213508 16219082 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01004867001 16213508 16219082 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01004867001 16213508 16219082 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01004867001 16213508 16219082 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01004867001 16213508 16219082 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01004867001 16213508 16219082 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01004867001 16213508 16219082 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01004867001 16213508 16219082 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01004867001 16213508 16219082 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01004867001 16213508 16219082 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01004867001 16213508 16219082 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01029923001 1539481 1540694 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01029923001 1539481 1540694 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01029923001 1539481 1540694 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01038141001 23799541 23804603 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01022317001 18433115 18434421 GSVIVG01019401001 349466 353491 GSVIVG01037875001 6846058 6849868 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01037875001 6846058 6849868 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. IEA GO:0004722 protein serine/threonine phosphatase activity GSVIVG01025247001 2739890 2745380 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01012890001 6552691 6554026 GSVIVG01035081001 1343317 1345600 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion. IEA GO:0004806 triglyceride lipase activity GSVIVG01018594001 12603700 12605136 GSVIVG01015682001 15529867 15532548 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01015682001 15529867 15532548 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01022120001 16738987 16739745 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01003903001 13398922 13400120 GSVIVG01016868001 2116851 2122604 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01001543001 1345817 1348225 GSVIVG01023448001 11729359 11730791 GSVIVG01022107001 16623222 16623766 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01022107001 16623222 16623766 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01022107001 16623222 16623766 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01031341001 240227 242110 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01024290001 578403 580042 GSVIVG01006430001 25843736 25846937 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01006430001 25843736 25846937 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01006430001 25843736 25846937 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01006430001 25843736 25846937 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033509001 20175993 20181367 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033509001 20175993 20181367 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033509001 20175993 20181367 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033509001 20175993 20181367 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Catalysis of the reaction: acyl-[acyl-carrier protein] + NAD+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+. IEA GO:0004318 enoyl-[acyl-carrier-protein] reductase (NADH) activity GSVIVG01033509001 20175993 20181367 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: acyl-[acyl-carrier protein] + NAD+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+. IEA GO:0004318 enoyl-[acyl-carrier-protein] reductase (NADH) activity GSVIVG01033509001 20175993 20181367 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: acyl-[acyl-carrier protein] + NAD+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+. IEA GO:0004318 enoyl-[acyl-carrier-protein] reductase (NADH) activity GSVIVG01033509001 20175993 20181367 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033509001 20175993 20181367 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033509001 20175993 20181367 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033509001 20175993 20181367 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033509001 20175993 20181367 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033509001 20175993 20181367 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01014098001 371902 374095 GSVIVG01003820001 20405866 20426069 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: 3-alpha(S)-strictosidine = tryptamine + secologanin. IEA GO:0016844 strictosidine synthase activity GSVIVG01010268001 18632672 18633953 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01010268001 18632672 18633953 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01010268001 18632672 18633953 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01010268001 18632672 18633953 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01010268001 18632672 18633953 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01010268001 18632672 18633953 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01010268001 18632672 18633953 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01010268001 18632672 18633953 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01010268001 18632672 18633953 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01010268001 18632672 18633953 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01038192001 24220238 24241107 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01038192001 24220238 24241107 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01038192001 24220238 24241107 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli. IEA GO:0004707 MAP kinase activity GSVIVG01038192001 24220238 24241107 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01038192001 24220238 24241107 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031993001 23694199 23700232 GSVIVG01008269001 3774075 3775250 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01008269001 3774075 3775250 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01025779001 11946600 11963168 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the reaction: ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. IEA GO:0004618 phosphoglycerate kinase activity GSVIVG01012075001 1620551 1621335 GSVIVG01035958001 6510450 6514013 GO:0006452 translational frameshifting A mechanism whereby different proteins may result from a single mRNA molecule, due to a change in the parsing of three nucleotides per codon relative to an initiating AUG codon. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01035958001 6510450 6514013 GO:0008612 peptidyl-lysine modification to hypusine The posttranslational modification of peptidyl-lysine to form hypusine, N6-(4-amino-2-hydroxybutyl)-L-lysine. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01035958001 6510450 6514013 GO:0045901 positive regulation of translational elongation Any process that activates or increases the frequency, rate or extent of translational elongation. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01035958001 6510450 6514013 GO:0045905 positive regulation of translational termination Any process that activates or increases the frequency, rate or extent of translational termination. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01035958001 6510450 6514013 GO:0006452 translational frameshifting A mechanism whereby different proteins may result from a single mRNA molecule, due to a change in the parsing of three nucleotides per codon relative to an initiating AUG codon. IEA Functions in chain elongation during polypeptide synthesis at the ribosome. IEA GO:0003746 translation elongation factor activity GSVIVG01035958001 6510450 6514013 GO:0008612 peptidyl-lysine modification to hypusine The posttranslational modification of peptidyl-lysine to form hypusine, N6-(4-amino-2-hydroxybutyl)-L-lysine. IEA Functions in chain elongation during polypeptide synthesis at the ribosome. IEA GO:0003746 translation elongation factor activity GSVIVG01035958001 6510450 6514013 GO:0045901 positive regulation of translational elongation Any process that activates or increases the frequency, rate or extent of translational elongation. IEA Functions in chain elongation during polypeptide synthesis at the ribosome. IEA GO:0003746 translation elongation factor activity GSVIVG01035958001 6510450 6514013 GO:0045905 positive regulation of translational termination Any process that activates or increases the frequency, rate or extent of translational termination. IEA Functions in chain elongation during polypeptide synthesis at the ribosome. IEA GO:0003746 translation elongation factor activity GSVIVG01035958001 6510450 6514013 GO:0006452 translational frameshifting A mechanism whereby different proteins may result from a single mRNA molecule, due to a change in the parsing of three nucleotides per codon relative to an initiating AUG codon. IEA Interacting selectively and non-covalently with any part of a ribosome. IEA GO:0043022 ribosome binding GSVIVG01035958001 6510450 6514013 GO:0008612 peptidyl-lysine modification to hypusine The posttranslational modification of peptidyl-lysine to form hypusine, N6-(4-amino-2-hydroxybutyl)-L-lysine. IEA Interacting selectively and non-covalently with any part of a ribosome. IEA GO:0043022 ribosome binding GSVIVG01035958001 6510450 6514013 GO:0045901 positive regulation of translational elongation Any process that activates or increases the frequency, rate or extent of translational elongation. IEA Interacting selectively and non-covalently with any part of a ribosome. IEA GO:0043022 ribosome binding GSVIVG01035958001 6510450 6514013 GO:0045905 positive regulation of translational termination Any process that activates or increases the frequency, rate or extent of translational termination. IEA Interacting selectively and non-covalently with any part of a ribosome. IEA GO:0043022 ribosome binding GSVIVG01027586001 15292110 15303630 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01027586001 15292110 15303630 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01027586001 15292110 15303630 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01027586001 15292110 15303630 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01015248001 2093896 2100497 GO:0016568 chromatin modification The alteration of DNA or protein in chromatin, which may result in changing the chromatin structure. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone. IEA GO:0004402 histone acetyltransferase activity GSVIVG01015248001 2093896 2100497 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone. IEA GO:0004402 histone acetyltransferase activity GSVIVG01015248001 2093896 2100497 GO:0016568 chromatin modification The alteration of DNA or protein in chromatin, which may result in changing the chromatin structure. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01015248001 2093896 2100497 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01031741001 3984149 3989228 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031741001 3984149 3989228 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01014513001 4694229 4695212 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014513001 4694229 4695212 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014513001 4694229 4695212 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014513001 4694229 4695212 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009681001 10403901 10426931 GSVIVG01007953001 7231479 7234983 GSVIVG01003714001 15107119 15107241 GSVIVG01019685001 2441373 2448473 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid. IEA GO:0008378 galactosyltransferase activity GSVIVG01029942001 1900037 1901212 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01029942001 1900037 1901212 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01017423001 8314142 8331895 GSVIVG01015525001 4492019 4499398 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar. IEA GO:0008375 acetylglucosaminyltransferase activity GSVIVG01009158001 5634170 5644314 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin. IEA GO:0004221 ubiquitin thiolesterase activity GSVIVG01009158001 5634170 5644314 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01015533001 4611380 4626665 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01015533001 4611380 4626665 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01015533001 4611380 4626665 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01015533001 4611380 4626665 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01031638001 19399774 19401611 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01031638001 19399774 19401611 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01032352001 26604782 26614204 GSVIVG01029724001 13764277 13773404 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025270001 2565436 2567947 GO:0016125 sterol metabolic process The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of the reaction: 5-alpha-cholest-7-en-3-beta-ol = 5-alpha-cholest-8-en-3-beta-ol. IEA GO:0047750 cholestenol delta-isomerase activity GSVIVG01025270001 2565436 2567947 GO:0016125 sterol metabolic process The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: 5-alpha-cholest-7-en-3-beta-ol = 5-alpha-cholest-8-en-3-beta-ol. IEA GO:0047750 cholestenol delta-isomerase activity GSVIVG01024518001 9367358 9373464 GSVIVG01009386001 7926705 7933328 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01009386001 7926705 7933328 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01023517001 10528574 10546325 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025447001 765825 767748 GSVIVG01007550001 12269629 12274239 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01007550001 12269629 12274239 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01007550001 12269629 12274239 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01007550001 12269629 12274239 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01007550001 12269629 12274239 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01007550001 12269629 12274239 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012553001 3507585 3507842 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01012553001 3507585 3507842 GO:0006423 cysteinyl-tRNA aminoacylation The process of coupling cysteine to cysteinyl-tRNA, catalyzed by cysteinyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01012553001 3507585 3507842 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys). IEA GO:0004817 cysteine-tRNA ligase activity GSVIVG01012553001 3507585 3507842 GO:0006423 cysteinyl-tRNA aminoacylation The process of coupling cysteine to cysteinyl-tRNA, catalyzed by cysteinyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys). IEA GO:0004817 cysteine-tRNA ligase activity GSVIVG01012553001 3507585 3507842 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012553001 3507585 3507842 GO:0006423 cysteinyl-tRNA aminoacylation The process of coupling cysteine to cysteinyl-tRNA, catalyzed by cysteinyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006798001 28623374 28623696 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01006798001 28623374 28623696 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01031729001 3882126 3887019 GSVIVG01011171001 7693491 7696200 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01011171001 7693491 7696200 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01000059001 3154938 3155144 GSVIVG01030771001 15705778 15706432 GSVIVG01011598001 6088273 6096479 GO:0050819 negative regulation of coagulation Any process that stops, prevents or reduces the frequency, rate or extent of coagulation. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01011598001 6088273 6096479 GO:0050819 negative regulation of coagulation Any process that stops, prevents or reduces the frequency, rate or extent of coagulation. IEA Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium. IEA GO:0005544 calcium-dependent phospholipid binding GSVIVG01000762001 498142 504281 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01000762001 498142 504281 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000762001 498142 504281 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01015015001 448473 458645 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01015015001 448473 458645 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012268001 12780418 12803911 GSVIVG01000947001 22185832 22196323 GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01024435001 2515225 2516111 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01019261001 2416033 2416758 GSVIVG01018328001 10984269 10987338 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01018328001 10984269 10987338 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01003667001 11936912 11950215 GSVIVG01035987001 6870734 6884939 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01035987001 6870734 6884939 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01035987001 6870734 6884939 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01035987001 6870734 6884939 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008560001 878131 881091 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01008560001 878131 881091 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01030176001 10829021 10834047 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01021703001 9773935 9775724 GSVIVG01029751001 14161384 14176091 GO:0032259 methylation The process by which a methyl group is covalently attached to a molecule. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01029751001 14161384 14176091 GO:0032259 methylation The process by which a methyl group is covalently attached to a molecule. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01010098001 15343874 15346615 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01035845001 4816136 4818232 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01035845001 4816136 4818232 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01020239001 8677831 8680798 GO:0006364 rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01020239001 8677831 8680798 GO:0006364 rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. IEA GO:0008173 RNA methyltransferase activity GSVIVG01020239001 8677831 8680798 GO:0006364 rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01033238001 22291996 22308730 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033238001 22291996 22308730 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033238001 22291996 22308730 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033238001 22291996 22308730 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033238001 22291996 22308730 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01033238001 22291996 22308730 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01033238001 22291996 22308730 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01033238001 22291996 22308730 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01033238001 22291996 22308730 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033238001 22291996 22308730 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033238001 22291996 22308730 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033238001 22291996 22308730 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033238001 22291996 22308730 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of calcium (Ca) ions from one side of a membrane to the other. IEA GO:0015085 calcium ion transmembrane transporter activity GSVIVG01033238001 22291996 22308730 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of calcium (Ca) ions from one side of a membrane to the other. IEA GO:0015085 calcium ion transmembrane transporter activity GSVIVG01033238001 22291996 22308730 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of calcium (Ca) ions from one side of a membrane to the other. IEA GO:0015085 calcium ion transmembrane transporter activity GSVIVG01033238001 22291996 22308730 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of calcium (Ca) ions from one side of a membrane to the other. IEA GO:0015085 calcium ion transmembrane transporter activity GSVIVG01033238001 22291996 22308730 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01033238001 22291996 22308730 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01033238001 22291996 22308730 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01033238001 22291996 22308730 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01033238001 22291996 22308730 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01033238001 22291996 22308730 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01033238001 22291996 22308730 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01033238001 22291996 22308730 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01030267001 9700790 9708407 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024170001 623792 624325 GSVIVG01000187001 15983300 15985109 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01000187001 15983300 15985109 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01000187001 15983300 15985109 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01000187001 15983300 15985109 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01015169001 1519429 1526389 GO:0016117 carotenoid biosynthetic process The chemical reactions and pathways resulting in the formation of carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01015169001 1519429 1526389 GO:0016117 carotenoid biosynthetic process The chemical reactions and pathways resulting in the formation of carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. IEA GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GSVIVG01037887001 6715491 6716068 GSVIVG01037482001 12938408 12939271 GSVIVG01036129001 20353990 20359299 GSVIVG01018581001 12887747 12889129 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GSVIVG01021932001 5491673 5492148 GO:0006801 superoxide metabolic process The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01021932001 5491673 5492148 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01027626001 14918183 14936056 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01027626001 14918183 14936056 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027626001 14918183 14936056 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033034001 25230755 25232710 GO:0006626 protein targeting to mitochondrion The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01033034001 25230755 25232710 GO:0006626 protein targeting to mitochondrion The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01033034001 25230755 25232710 GO:0006626 protein targeting to mitochondrion The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01033034001 25230755 25232710 GO:0006626 protein targeting to mitochondrion The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein. IEA GO:0042719 mitochondrial intermembrane space protein transporter complex Soluble complex of the mitochondrial intermembrane space composed of various combinations of small Tim proteins; acts as a protein transporter to guide proteins to the Tim22 complex for insertion into the mitochondrial inner membrane. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01033034001 25230755 25232710 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01033034001 25230755 25232710 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01033034001 25230755 25232710 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01033034001 25230755 25232710 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0042719 mitochondrial intermembrane space protein transporter complex Soluble complex of the mitochondrial intermembrane space composed of various combinations of small Tim proteins; acts as a protein transporter to guide proteins to the Tim22 complex for insertion into the mitochondrial inner membrane. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01033034001 25230755 25232710 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01033034001 25230755 25232710 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01033034001 25230755 25232710 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01033034001 25230755 25232710 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0042719 mitochondrial intermembrane space protein transporter complex Soluble complex of the mitochondrial intermembrane space composed of various combinations of small Tim proteins; acts as a protein transporter to guide proteins to the Tim22 complex for insertion into the mitochondrial inner membrane. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01033034001 25230755 25232710 GO:0045039 protein import into mitochondrial inner membrane The import of proteins into the mitochondria inner membrane. Inner membrane proteins are first imported into the matrix space where the matrix-targeting sequence is removed; how these proteins then are incorporated into the inner membrane is not known. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01033034001 25230755 25232710 GO:0045039 protein import into mitochondrial inner membrane The import of proteins into the mitochondria inner membrane. Inner membrane proteins are first imported into the matrix space where the matrix-targeting sequence is removed; how these proteins then are incorporated into the inner membrane is not known. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01033034001 25230755 25232710 GO:0045039 protein import into mitochondrial inner membrane The import of proteins into the mitochondria inner membrane. Inner membrane proteins are first imported into the matrix space where the matrix-targeting sequence is removed; how these proteins then are incorporated into the inner membrane is not known. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01033034001 25230755 25232710 GO:0045039 protein import into mitochondrial inner membrane The import of proteins into the mitochondria inner membrane. Inner membrane proteins are first imported into the matrix space where the matrix-targeting sequence is removed; how these proteins then are incorporated into the inner membrane is not known. IEA GO:0042719 mitochondrial intermembrane space protein transporter complex Soluble complex of the mitochondrial intermembrane space composed of various combinations of small Tim proteins; acts as a protein transporter to guide proteins to the Tim22 complex for insertion into the mitochondrial inner membrane. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01033034001 25230755 25232710 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01033034001 25230755 25232710 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01033034001 25230755 25232710 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01033034001 25230755 25232710 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0042719 mitochondrial intermembrane space protein transporter complex Soluble complex of the mitochondrial intermembrane space composed of various combinations of small Tim proteins; acts as a protein transporter to guide proteins to the Tim22 complex for insertion into the mitochondrial inner membrane. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01033034001 25230755 25232710 GO:0006626 protein targeting to mitochondrion The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01033034001 25230755 25232710 GO:0006626 protein targeting to mitochondrion The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01033034001 25230755 25232710 GO:0006626 protein targeting to mitochondrion The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01033034001 25230755 25232710 GO:0006626 protein targeting to mitochondrion The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein. IEA GO:0042719 mitochondrial intermembrane space protein transporter complex Soluble complex of the mitochondrial intermembrane space composed of various combinations of small Tim proteins; acts as a protein transporter to guide proteins to the Tim22 complex for insertion into the mitochondrial inner membrane. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01033034001 25230755 25232710 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01033034001 25230755 25232710 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01033034001 25230755 25232710 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01033034001 25230755 25232710 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0042719 mitochondrial intermembrane space protein transporter complex Soluble complex of the mitochondrial intermembrane space composed of various combinations of small Tim proteins; acts as a protein transporter to guide proteins to the Tim22 complex for insertion into the mitochondrial inner membrane. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01033034001 25230755 25232710 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01033034001 25230755 25232710 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01033034001 25230755 25232710 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01033034001 25230755 25232710 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0042719 mitochondrial intermembrane space protein transporter complex Soluble complex of the mitochondrial intermembrane space composed of various combinations of small Tim proteins; acts as a protein transporter to guide proteins to the Tim22 complex for insertion into the mitochondrial inner membrane. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01033034001 25230755 25232710 GO:0045039 protein import into mitochondrial inner membrane The import of proteins into the mitochondria inner membrane. Inner membrane proteins are first imported into the matrix space where the matrix-targeting sequence is removed; how these proteins then are incorporated into the inner membrane is not known. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01033034001 25230755 25232710 GO:0045039 protein import into mitochondrial inner membrane The import of proteins into the mitochondria inner membrane. Inner membrane proteins are first imported into the matrix space where the matrix-targeting sequence is removed; how these proteins then are incorporated into the inner membrane is not known. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01033034001 25230755 25232710 GO:0045039 protein import into mitochondrial inner membrane The import of proteins into the mitochondria inner membrane. Inner membrane proteins are first imported into the matrix space where the matrix-targeting sequence is removed; how these proteins then are incorporated into the inner membrane is not known. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01033034001 25230755 25232710 GO:0045039 protein import into mitochondrial inner membrane The import of proteins into the mitochondria inner membrane. Inner membrane proteins are first imported into the matrix space where the matrix-targeting sequence is removed; how these proteins then are incorporated into the inner membrane is not known. IEA GO:0042719 mitochondrial intermembrane space protein transporter complex Soluble complex of the mitochondrial intermembrane space composed of various combinations of small Tim proteins; acts as a protein transporter to guide proteins to the Tim22 complex for insertion into the mitochondrial inner membrane. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01033034001 25230755 25232710 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01033034001 25230755 25232710 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01033034001 25230755 25232710 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01033034001 25230755 25232710 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0042719 mitochondrial intermembrane space protein transporter complex Soluble complex of the mitochondrial intermembrane space composed of various combinations of small Tim proteins; acts as a protein transporter to guide proteins to the Tim22 complex for insertion into the mitochondrial inner membrane. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01021823001 6917560 6920202 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01025589001 13806226 13836994 GSVIVG01030936001 19336707 19336926 GSVIVG01016820001 1657565 1659821 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01016820001 1657565 1659821 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01016820001 1657565 1659821 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01016820001 1657565 1659821 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01016820001 1657565 1659821 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA The action of a molecule that contributes to the structural integrity of a cell wall. IEA GO:0005199 structural constituent of cell wall GSVIVG01016820001 1657565 1659821 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The action of a molecule that contributes to the structural integrity of a cell wall. IEA GO:0005199 structural constituent of cell wall GSVIVG01016820001 1657565 1659821 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA The action of a molecule that contributes to the structural integrity of a cell wall. IEA GO:0005199 structural constituent of cell wall GSVIVG01016820001 1657565 1659821 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The action of a molecule that contributes to the structural integrity of a cell wall. IEA GO:0005199 structural constituent of cell wall GSVIVG01016820001 1657565 1659821 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01016820001 1657565 1659821 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01016820001 1657565 1659821 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01016820001 1657565 1659821 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01010595001 16193301 16199121 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01010595001 16193301 16199121 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01037067001 8216601 8219583 GSVIVG01032269001 14297729 14310249 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01032269001 14297729 14310249 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01032269001 14297729 14310249 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01032269001 14297729 14310249 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027550001 15751441 15761968 GSVIVG01037706001 7121824 7124124 GO:0006207 'de novo' pyrimidine base biosynthetic process The chemical reactions and pathways resulting in the formation of pyrimidine bases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors. IEA GO:0009348 ornithine carbamoyltransferase complex A homotrimeric protein complex that catalyzes the transfer of a carbamoyl group to ornithine, forming citrulline. IEA Catalysis of the reaction: carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. IEA GO:0004070 aspartate carbamoyltransferase activity GSVIVG01037706001 7121824 7124124 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA GO:0009348 ornithine carbamoyltransferase complex A homotrimeric protein complex that catalyzes the transfer of a carbamoyl group to ornithine, forming citrulline. IEA Catalysis of the reaction: carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. IEA GO:0004070 aspartate carbamoyltransferase activity GSVIVG01037706001 7121824 7124124 GO:0006207 'de novo' pyrimidine base biosynthetic process The chemical reactions and pathways resulting in the formation of pyrimidine bases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors. IEA GO:0009348 ornithine carbamoyltransferase complex A homotrimeric protein complex that catalyzes the transfer of a carbamoyl group to ornithine, forming citrulline. IEA Catalysis of the reaction: carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. IEA GO:0004585 ornithine carbamoyltransferase activity GSVIVG01037706001 7121824 7124124 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA GO:0009348 ornithine carbamoyltransferase complex A homotrimeric protein complex that catalyzes the transfer of a carbamoyl group to ornithine, forming citrulline. IEA Catalysis of the reaction: carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. IEA GO:0004585 ornithine carbamoyltransferase activity GSVIVG01037706001 7121824 7124124 GO:0006207 'de novo' pyrimidine base biosynthetic process The chemical reactions and pathways resulting in the formation of pyrimidine bases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors. IEA GO:0009348 ornithine carbamoyltransferase complex A homotrimeric protein complex that catalyzes the transfer of a carbamoyl group to ornithine, forming citrulline. IEA Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. IEA GO:0016597 amino acid binding GSVIVG01037706001 7121824 7124124 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA GO:0009348 ornithine carbamoyltransferase complex A homotrimeric protein complex that catalyzes the transfer of a carbamoyl group to ornithine, forming citrulline. IEA Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. IEA GO:0016597 amino acid binding GSVIVG01037706001 7121824 7124124 GO:0006207 'de novo' pyrimidine base biosynthetic process The chemical reactions and pathways resulting in the formation of pyrimidine bases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors. IEA GO:0009348 ornithine carbamoyltransferase complex A homotrimeric protein complex that catalyzes the transfer of a carbamoyl group to ornithine, forming citrulline. IEA Catalysis of the transfer of a carboxyl- or carbamoyl group from one compound (donor) to another (acceptor). IEA GO:0016743 carboxyl- or carbamoyltransferase activity GSVIVG01037706001 7121824 7124124 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA GO:0009348 ornithine carbamoyltransferase complex A homotrimeric protein complex that catalyzes the transfer of a carbamoyl group to ornithine, forming citrulline. IEA Catalysis of the transfer of a carboxyl- or carbamoyl group from one compound (donor) to another (acceptor). IEA GO:0016743 carboxyl- or carbamoyltransferase activity GSVIVG01037668001 6697728 6702141 GSVIVG01025648001 13323755 13326728 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01014980001 13632902 13633389 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01035374001 859049 863968 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01035374001 859049 863968 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01035374001 859049 863968 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01035374001 859049 863968 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035374001 859049 863968 Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01035374001 859049 863968 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01016379001 4357952 4359106 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016379001 4357952 4359106 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016379001 4357952 4359106 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01016379001 4357952 4359106 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01016379001 4357952 4359106 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01016379001 4357952 4359106 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01016379001 4357952 4359106 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01016379001 4357952 4359106 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01016379001 4357952 4359106 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01016379001 4357952 4359106 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01027087001 18026057 18036291 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01027087001 18026057 18036291 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01011255001 10152560 10155130 Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01014499001 4516282 4525721 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014499001 4516282 4525721 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014499001 4516282 4525721 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014499001 4516282 4525721 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014499001 4516282 4525721 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014499001 4516282 4525721 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014499001 4516282 4525721 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014499001 4516282 4525721 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014499001 4516282 4525721 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01014499001 4516282 4525721 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01001061001 7197253 7200946 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001061001 7197253 7200946 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001061001 7197253 7200946 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001061001 7197253 7200946 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01001061001 7197253 7200946 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01001061001 7197253 7200946 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01001061001 7197253 7200946 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01001061001 7197253 7200946 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01001061001 7197253 7200946 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01001061001 7197253 7200946 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01001061001 7197253 7200946 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01001061001 7197253 7200946 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01001061001 7197253 7200946 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01001061001 7197253 7200946 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01001061001 7197253 7200946 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01001061001 7197253 7200946 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01001061001 7197253 7200946 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01001061001 7197253 7200946 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01001061001 7197253 7200946 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001061001 7197253 7200946 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001061001 7197253 7200946 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001061001 7197253 7200946 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01001061001 7197253 7200946 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01001061001 7197253 7200946 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01009519001 9025103 9026342 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01034021001 15786367 15791185 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01034021001 15786367 15791185 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01018827001 19524046 19544727 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01018827001 19524046 19544727 GO:0016570 histone modification The covalent alteration of one or more amino acid residues within a histone protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01018827001 19524046 19544727 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01018827001 19524046 19544727 GO:0016570 histone modification The covalent alteration of one or more amino acid residues within a histone protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01018827001 19524046 19544727 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018827001 19524046 19544727 GO:0016570 histone modification The covalent alteration of one or more amino acid residues within a histone protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018827001 19524046 19544727 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01018827001 19524046 19544727 GO:0016570 histone modification The covalent alteration of one or more amino acid residues within a histone protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01015646001 14836670 14838402 GSVIVG01030780001 15877712 15880885 GO:0006011 UDP-glucose metabolic process The chemical reactions and pathways involving UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030780001 15877712 15880885 GO:0009405 pathogenesis The set of specific processes that generate the ability of an organism to cause disease in another. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01038349001 13374811 13375909 Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01015412001 3381622 3394368 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01015412001 3381622 3394368 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01015412001 3381622 3394368 GO:0008272 sulfate transport The directed movement of sulfate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01015412001 3381622 3394368 GO:0008272 sulfate transport The directed movement of sulfate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01015412001 3381622 3394368 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01015412001 3381622 3394368 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01015412001 3381622 3394368 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01015412001 3381622 3394368 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01015412001 3381622 3394368 GO:0008272 sulfate transport The directed movement of sulfate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01015412001 3381622 3394368 GO:0008272 sulfate transport The directed movement of sulfate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01015412001 3381622 3394368 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01015412001 3381622 3394368 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01036216001 8843293 8843529 GSVIVG01026300001 13017351 13019076 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01026300001 13017351 13019076 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01026300001 13017351 13019076 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010073001 14811852 14816337 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01010073001 14811852 14816337 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01010073001 14811852 14816337 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01010073001 14811852 14816337 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01010073001 14811852 14816337 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016608001 2456935 2458895 GSVIVG01038449001 12554388 12560861 GSVIVG01036380001 4424410 4438540 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035110001 1539367 1543319 GSVIVG01034080001 15334228 15340962 Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01032476001 27753738 27755451 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01032476001 27753738 27755451 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end. IEA GO:0004527 exonuclease activity GSVIVG01032476001 27753738 27755451 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01030760001 15490687 15495087 GSVIVG01016859001 2055028 2062378 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016859001 2055028 2062378 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016859001 2055028 2062378 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016859001 2055028 2062378 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015465001 3959483 3965721 GSVIVG01016454001 3751858 3752355 GSVIVG01021235001 2839559 2855995 GSVIVG01026261001 15100708 15106946 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01017843001 3961007 3965332 GSVIVG01009234001 6502785 6504375 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01000040001 2981439 2989175 GSVIVG01012313001 13475667 13476382 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of copper (Cu) ions from one side of a membrane to the other. IEA GO:0005375 copper ion transmembrane transporter activity GSVIVG01018910001 18723063 18724798 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01025907001 27341191 27342959 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01025907001 27341191 27342959 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01035890001 5372703 5390746 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01035890001 5372703 5390746 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035890001 5372703 5390746 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01018459001 14775868 14778037 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01013436001 492065 492984 GSVIVG01031627001 19111216 19112436 GSVIVG01021547001 6884976 6893965 GSVIVG01037359001 15071172 15072602 Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01037359001 15071172 15072602 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01016626001 2358305 2359845 GSVIVG01005911001 22534379 22534828 GSVIVG01017218001 5563405 5570700 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01017218001 5563405 5570700 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01017218001 5563405 5570700 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01010865001 16724545 16736125 GSVIVG01022837001 18902629 18927920 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022837001 18902629 18927920 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038308001 12578222 12579122 GSVIVG01023951001 2225337 2228568 GO:0006904 vesicle docking involved in exocytosis The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis. IEA GSVIVG01023951001 2225337 2228568 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GSVIVG01008272001 3761460 3762435 GO:0006869 lipid transport The directed movement of lipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Interacting selectively and non-covalently with a lipid. IEA GO:0008289 lipid binding GSVIVG01018760001 20121868 20123157 GSVIVG01032651001 1809332 1811147 GO:0006817 phosphate transport The directed movement of phosphate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a inorganic phosphate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0005315 inorganic phosphate transmembrane transporter activity GSVIVG01032651001 1809332 1811147 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a inorganic phosphate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0005315 inorganic phosphate transmembrane transporter activity GSVIVG01005037001 17557784 17558403 GSVIVG01030800001 16269616 16274875 GSVIVG01022085001 16474650 16478530 GSVIVG01033912001 16793961 16794886 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033912001 16793961 16794886 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033912001 16793961 16794886 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033912001 16793961 16794886 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033912001 16793961 16794886 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033912001 16793961 16794886 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033912001 16793961 16794886 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01033912001 16793961 16794886 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01033912001 16793961 16794886 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01033912001 16793961 16794886 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033912001 16793961 16794886 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033912001 16793961 16794886 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031442001 18538106 18540119 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0008236 serine-type peptidase activity GSVIVG01011864001 3450807 3467015 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01011864001 3450807 3467015 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01014310001 2537068 2537838 GSVIVG01034153001 14800030 14800908 GSVIVG01030356001 4941455 4941937 GSVIVG01000269001 20836494 20837958 GSVIVG01034389001 16923755 16926005 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01034389001 16923755 16926005 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01029561001 21550165 21563150 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01004090001 14723627 14724485 GSVIVG01017070001 3952902 3955812 Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. IEA GO:0005089 Rho guanyl-nucleotide exchange factor activity GSVIVG01028778001 18911455 18912023 GSVIVG01026921001 19386903 19389192 GSVIVG01012857001 6231269 6264098 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020066001 10860182 10861942 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01020066001 10860182 10861942 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01004783001 16092797 16093709 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01004783001 16092797 16093709 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01020647001 3482933 3498071 Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. IEA GO:0008171 O-methyltransferase activity GSVIVG01015504001 4286521 4295659 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01015504001 4286521 4295659 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01005375001 39908700 39909958 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01005375001 39908700 39909958 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01005375001 39908700 39909958 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01005375001 39908700 39909958 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021291001 3556246 3578182 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01021291001 3556246 3578182 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01021291001 3556246 3578182 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01021291001 3556246 3578182 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01021291001 3556246 3578182 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016921001 2575976 2576204 GSVIVG01025503001 264280 274992 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01019320001 1166023 1169412 GSVIVG01004780001 16068101 16068403 GSVIVG01034716001 8297834 8300478 GSVIVG01010162001 16601694 16612318 GSVIVG01011705001 4928289 4931588 GSVIVG01005814001 22057277 22059864 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01005814001 22057277 22059864 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031161001 1593031 1597815 GSVIVG01029282001 17640341 17648014 GO:0006725 cellular aromatic compound metabolic process The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01029282001 17640341 17648014 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01029282001 17640341 17648014 GO:0006725 cellular aromatic compound metabolic process The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01029282001 17640341 17648014 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01029282001 17640341 17648014 GO:0006725 cellular aromatic compound metabolic process The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells. IEA Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051537 2 iron, 2 sulfur cluster binding GSVIVG01029282001 17640341 17648014 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051537 2 iron, 2 sulfur cluster binding GSVIVG01030697001 13742223 13745992 GO:0006542 glutamine biosynthetic process The chemical reactions and pathways resulting in the formation of glutamine, 2-amino-4-carbamoylbutanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01030697001 13742223 13745992 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01030697001 13742223 13745992 GO:0006542 glutamine biosynthetic process The chemical reactions and pathways resulting in the formation of glutamine, 2-amino-4-carbamoylbutanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030697001 13742223 13745992 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030697001 13742223 13745992 GO:0006542 glutamine biosynthetic process The chemical reactions and pathways resulting in the formation of glutamine, 2-amino-4-carbamoylbutanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine. IEA GO:0004356 glutamate-ammonia ligase activity GSVIVG01030697001 13742223 13745992 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine. IEA GO:0004356 glutamate-ammonia ligase activity GSVIVG01030697001 13742223 13745992 GO:0006542 glutamine biosynthetic process The chemical reactions and pathways resulting in the formation of glutamine, 2-amino-4-carbamoylbutanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030697001 13742223 13745992 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030697001 13742223 13745992 GO:0006542 glutamine biosynthetic process The chemical reactions and pathways resulting in the formation of glutamine, 2-amino-4-carbamoylbutanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01030697001 13742223 13745992 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01008030001 6493136 6493937 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01023994001 1872348 1877380 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01023994001 1872348 1877380 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. IEA GO:0004722 protein serine/threonine phosphatase activity GSVIVG01011219001 9685126 9701385 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Interacting selectively and non-covalently with damaged DNA. IEA GO:0003684 damaged DNA binding GSVIVG01011219001 9685126 9701385 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025769001 12093721 12096320 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004185 serine-type carboxypeptidase activity GSVIVG01032613001 2211611 2213305 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032613001 2211611 2213305 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032613001 2211611 2213305 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032613001 2211611 2213305 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01032613001 2211611 2213305 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01032613001 2211611 2213305 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01032613001 2211611 2213305 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01032613001 2211611 2213305 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01032613001 2211611 2213305 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01022205001 17452936 17461521 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01022205001 17452936 17461521 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01022205001 17452936 17461521 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01022205001 17452936 17461521 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01010746001 22077795 22089719 GO:0016485 protein processing Any protein maturation process achieved by the cleavage of peptide bonds. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01010746001 22077795 22089719 GO:0043085 positive regulation of catalytic activity Any process that activates or increases the activity of an enzyme. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01003126001 7495607 7495759 GSVIVG01018028001 5622650 5631076 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01018028001 5622650 5631076 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01018028001 5622650 5631076 GO:0008272 sulfate transport The directed movement of sulfate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01018028001 5622650 5631076 GO:0008272 sulfate transport The directed movement of sulfate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01018028001 5622650 5631076 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01018028001 5622650 5631076 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01018028001 5622650 5631076 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01018028001 5622650 5631076 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01018028001 5622650 5631076 GO:0008272 sulfate transport The directed movement of sulfate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01018028001 5622650 5631076 GO:0008272 sulfate transport The directed movement of sulfate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01018028001 5622650 5631076 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01018028001 5622650 5631076 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01003212001 7958360 7975590 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01003212001 7958360 7975590 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01009907001 12302978 12305109 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01009907001 12302978 12305109 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001365001 24014934 24021411 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01001365001 24014934 24021411 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01020553001 4449171 4452824 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01020553001 4449171 4452824 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01020553001 4449171 4452824 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01016605001 2466582 2468391 GSVIVG01033557001 19763293 19771775 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. IEA GO:0008080 N-acetyltransferase activity GSVIVG01019870001 4081776 4093358 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GSVIVG01036468001 22404874 22411827 GSVIVG01000151001 15674584 15682376 Interacting selectively and non-covalently with acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group. IEA GO:0000062 acyl-CoA binding GSVIVG01000151001 15674584 15682376 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01000005001 2642583 2643125 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01020746001 2402145 2404091 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01020746001 2402145 2404091 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01020746001 2402145 2404091 Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01015509001 4327772 4333487 GSVIVG01001621001 21432950 21433081 GSVIVG01018492001 14336620 14338047 GSVIVG01012819001 5712791 5718234 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036101001 20711501 20713674 GSVIVG01005683001 21235023 21237421 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01005683001 21235023 21237421 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01005683001 21235023 21237421 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01005683001 21235023 21237421 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01005683001 21235023 21237421 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01005683001 21235023 21237421 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01005683001 21235023 21237421 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01005683001 21235023 21237421 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01005683001 21235023 21237421 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01005683001 21235023 21237421 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01005683001 21235023 21237421 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01005683001 21235023 21237421 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01029170001 18960277 18961530 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01029170001 18960277 18961530 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01029170001 18960277 18961530 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01029170001 18960277 18961530 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01029170001 18960277 18961530 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01029170001 18960277 18961530 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01029170001 18960277 18961530 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01029170001 18960277 18961530 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01017718001 2877562 2880014 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01017718001 2877562 2880014 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01011101001 1577482 1583295 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: 2 glutathione + H2O2 = oxidized glutathione + 2 H2O. IEA GO:0004602 glutathione peroxidase activity GSVIVG01011101001 1577482 1583295 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2 glutathione + H2O2 = oxidized glutathione + 2 H2O. IEA GO:0004602 glutathione peroxidase activity GSVIVG01006804001 28704835 28706107 GO:0009186 deoxyribonucleoside diphosphate metabolic process The chemical reactions and pathways involving a deoxyribonucleoside diphosphate, a glycosamine consisting of a base linked to a deoxyribose sugar esterified with diphosphate on its glycose moiety. IEA Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin. IEA GO:0004748 ribonucleoside-diphosphate reductase activity GSVIVG01006804001 28704835 28706107 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin. IEA GO:0004748 ribonucleoside-diphosphate reductase activity GSVIVG01006804001 28704835 28706107 GO:0009186 deoxyribonucleoside diphosphate metabolic process The chemical reactions and pathways involving a deoxyribonucleoside diphosphate, a glycosamine consisting of a base linked to a deoxyribose sugar esterified with diphosphate on its glycose moiety. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01006804001 28704835 28706107 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01006804001 28704835 28706107 GO:0009186 deoxyribonucleoside diphosphate metabolic process The chemical reactions and pathways involving a deoxyribonucleoside diphosphate, a glycosamine consisting of a base linked to a deoxyribose sugar esterified with diphosphate on its glycose moiety. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01006804001 28704835 28706107 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01023800001 3396907 3400842 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01023800001 3396907 3400842 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01023800001 3396907 3400842 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01023800001 3396907 3400842 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01023800001 3396907 3400842 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01023800001 3396907 3400842 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01010366001 19868496 19868696 GSVIVG01008629001 294342 299620 GSVIVG01023362001 19287413 19291695 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01023362001 19287413 19291695 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01023362001 19287413 19291695 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01023362001 19287413 19291695 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023362001 19287413 19291695 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01005876001 22445876 22446247 GSVIVG01032669001 1651787 1660629 Interacting selectively and non-covalently with transfer RNA. IEA GO:0000049 tRNA binding GSVIVG01027910001 9257999 9260162 GSVIVG01028932001 17278298 17309401 GSVIVG01030894001 18484263 18501388 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01013257001 6174298 6176424 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01013257001 6174298 6176424 GO:0008037 cell recognition The process by which a cell in a multicellular organism interprets its surroundings. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01013257001 6174298 6176424 GO:0019058 viral infectious cycle A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01013257001 6174298 6176424 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01013257001 6174298 6176424 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01013257001 6174298 6176424 GO:0008037 cell recognition The process by which a cell in a multicellular organism interprets its surroundings. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01013257001 6174298 6176424 GO:0019058 viral infectious cycle A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01013257001 6174298 6176424 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01005829001 328388 329272 GSVIVG01023233001 20842528 20849118 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01023233001 20842528 20849118 GO:0043087 regulation of GTPase activity Any process that modulates the rate of GTP hydrolysis by a GTPase. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01023233001 20842528 20849118 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024019001 1715843 1721233 GO:0008654 phospholipid biosynthetic process The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor). IEA GO:0016780 phosphotransferase activity, for other substituted phosphate groups GSVIVG01007330001 31398666 31400698 GSVIVG01024905001 6137401 6141857 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024905001 6137401 6141857 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01014069001 79524 84532 GO:0009813 flavonoid biosynthetic process The chemical reactions and pathways resulting in the formation of flavonoids, a group of phenolic derivatives containing a flavan skeleton. IEA The catalysis of certain rearrangements of a molecule to break or form a ring. IEA GO:0016872 intramolecular lyase activity GSVIVG01014069001 79524 84532 GO:0042398 cellular amino acid derivative biosynthetic process The chemical reactions and pathways resulting in the formation of compounds derived from amino acids, organic acids containing one or more amino substituents. IEA The catalysis of certain rearrangements of a molecule to break or form a ring. IEA GO:0016872 intramolecular lyase activity GSVIVG01014069001 79524 84532 GO:0009813 flavonoid biosynthetic process The chemical reactions and pathways resulting in the formation of flavonoids, a group of phenolic derivatives containing a flavan skeleton. IEA Catalysis of the reaction: a chalcone = a flavanone. IEA GO:0045430 chalcone isomerase activity GSVIVG01014069001 79524 84532 GO:0042398 cellular amino acid derivative biosynthetic process The chemical reactions and pathways resulting in the formation of compounds derived from amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the reaction: a chalcone = a flavanone. IEA GO:0045430 chalcone isomerase activity GSVIVG01031788001 4367150 4367733 GSVIVG01028819001 18393312 18395954 GSVIVG01008879001 3064369 3065897 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA GSVIVG01026116001 24385916 24389542 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01026116001 24385916 24389542 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01032327001 15101629 15102609 GSVIVG01021244001 2922910 2925537 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01021244001 2922910 2925537 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01014481001 4300428 4304176 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014481001 4300428 4304176 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014481001 4300428 4304176 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014481001 4300428 4304176 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014481001 4300428 4304176 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014481001 4300428 4304176 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014481001 4300428 4304176 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014481001 4300428 4304176 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014481001 4300428 4304176 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01014481001 4300428 4304176 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01031285001 617074 617834 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01014825001 10195356 10195601 GSVIVG01010549001 16729263 16732006 GSVIVG01012768001 23559862 23561862 GSVIVG01036780001 22662521 22670040 GSVIVG01033764001 18030954 18033862 GSVIVG01013774001 7713304 7718420 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01013774001 7713304 7718420 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01035429001 1224641 1225293 GSVIVG01029051001 11466233 11468334 GSVIVG01015070001 824727 828366 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01015070001 824727 828366 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01015070001 824727 828366 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01032616001 2191932 2193104 GSVIVG01018297001 11580934 11583111 GO:0006183 GTP biosynthetic process The chemical reactions and pathways resulting in the formation of GTP, guanosine triphosphate. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01018297001 11580934 11583111 GO:0006228 UTP biosynthetic process The chemical reactions and pathways resulting in the formation of UTP, uridine (5'-)triphosphate. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01018297001 11580934 11583111 GO:0006241 CTP biosynthetic process The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01018297001 11580934 11583111 GO:0006183 GTP biosynthetic process The chemical reactions and pathways resulting in the formation of GTP, guanosine triphosphate. IEA Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. IEA GO:0004550 nucleoside diphosphate kinase activity GSVIVG01018297001 11580934 11583111 GO:0006228 UTP biosynthetic process The chemical reactions and pathways resulting in the formation of UTP, uridine (5'-)triphosphate. IEA Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. IEA GO:0004550 nucleoside diphosphate kinase activity GSVIVG01018297001 11580934 11583111 GO:0006241 CTP biosynthetic process The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate. IEA Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. IEA GO:0004550 nucleoside diphosphate kinase activity GSVIVG01018297001 11580934 11583111 GO:0006183 GTP biosynthetic process The chemical reactions and pathways resulting in the formation of GTP, guanosine triphosphate. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018297001 11580934 11583111 GO:0006228 UTP biosynthetic process The chemical reactions and pathways resulting in the formation of UTP, uridine (5'-)triphosphate. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018297001 11580934 11583111 GO:0006241 CTP biosynthetic process The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018297001 11580934 11583111 GO:0006183 GTP biosynthetic process The chemical reactions and pathways resulting in the formation of GTP, guanosine triphosphate. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01018297001 11580934 11583111 GO:0006228 UTP biosynthetic process The chemical reactions and pathways resulting in the formation of UTP, uridine (5'-)triphosphate. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01018297001 11580934 11583111 GO:0006241 CTP biosynthetic process The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01018297001 11580934 11583111 GO:0006183 GTP biosynthetic process The chemical reactions and pathways resulting in the formation of GTP, guanosine triphosphate. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01018297001 11580934 11583111 GO:0006228 UTP biosynthetic process The chemical reactions and pathways resulting in the formation of UTP, uridine (5'-)triphosphate. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01018297001 11580934 11583111 GO:0006241 CTP biosynthetic process The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01000504001 15141269 15176293 Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01000504001 15141269 15176293 Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01000504001 15141269 15176293 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01000504001 15141269 15176293 Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01017373001 7518574 7519620 GSVIVG01019729001 2788379 2791515 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01031165001 1572075 1579550 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Stops, prevents or reduces the activity of an enzyme. IEA GO:0004857 enzyme inhibitor activity GSVIVG01031165001 1572075 1579550 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the reaction: pectin + n H2O = n methanol + pectate. IEA GO:0030599 pectinesterase activity GSVIVG01033726001 18308666 18314201 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01011657001 5493954 5552597 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01027011001 18583901 18583984 GSVIVG01010579001 16408256 16409930 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010579001 16408256 16409930 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010579001 16408256 16409930 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01010579001 16408256 16409930 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01006466001 26195557 26197827 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01021694001 9709089 9712190 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01021694001 9709089 9712190 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01021694001 9709089 9712190 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01021694001 9709089 9712190 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01021694001 9709089 9712190 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027744001 7361104 7362625 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01018499001 14269762 14271192 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01019604001 1882204 1882979 GSVIVG01030325001 8867831 8870313 GSVIVG01014537001 4935375 4943417 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014537001 4935375 4943417 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014537001 4935375 4943417 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014537001 4935375 4943417 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014537001 4935375 4943417 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014537001 4935375 4943417 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014537001 4935375 4943417 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014537001 4935375 4943417 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006127001 41879765 41880292 GSVIVG01035755001 4015551 4016530 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01033935001 16595281 16597123 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01008758001 1743055 1758026 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01012223001 448024 451702 GSVIVG01030963001 19804148 19805093 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01030963001 19804148 19805093 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01003333001 9130404 9135066 GSVIVG01017159001 4853689 4862125 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01017159001 4853689 4862125 GO:0009734 auxin mediated signaling pathway The series of molecular signals generated in response to detection of auxin. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01017159001 4853689 4862125 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01026953001 19076770 19083025 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01026953001 19076770 19083025 GO:0019941 modification-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01026953001 19076770 19083025 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01026953001 19076770 19083025 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01026953001 19076770 19083025 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01026953001 19076770 19083025 GO:0019941 modification-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01026953001 19076770 19083025 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01026953001 19076770 19083025 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01026953001 19076770 19083025 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01026953001 19076770 19083025 GO:0019941 modification-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01026953001 19076770 19083025 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01026953001 19076770 19083025 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01014955001 12837510 12837996 GSVIVG01009181001 5833780 5844784 GO:0042450 arginine biosynthetic process via ornithine The chemical reactions and pathways resulting in the formation of arginine (2-amino-5-guanidinopentanoic acid) via the intermediate compound ornithine. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009181001 5833780 5844784 GO:0042450 arginine biosynthetic process via ornithine The chemical reactions and pathways resulting in the formation of arginine (2-amino-5-guanidinopentanoic acid) via the intermediate compound ornithine. IEA Catalysis of the reaction: N-(L-arginino)succinate = fumarate + L-arginine. IEA GO:0004056 argininosuccinate lyase activity GSVIVG01035206001 10466610 10466744 GSVIVG01035539001 2133887 2141467 GSVIVG01009358001 7722609 7729941 GO:0006168 adenine salvage Any process that generates adenine, 6-aminopurine, from derivatives of it without de novo synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate. IEA GO:0003999 adenine phosphoribosyltransferase activity GSVIVG01009358001 7722609 7729941 GO:0009116 nucleoside metabolic process The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine). IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate. IEA GO:0003999 adenine phosphoribosyltransferase activity GSVIVG01026579001 21444204 21466018 GSVIVG01003961001 14100543 14102282 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01023169001 21732913 21733747 GSVIVG01030264001 9740185 9742655 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01016538001 3000466 3002046 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01016538001 3000466 3002046 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01030704001 14061406 14086882 GSVIVG01024927001 5958396 5965557 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01024927001 5958396 5965557 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01024927001 5958396 5965557 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01024927001 5958396 5965557 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01024927001 5958396 5965557 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024927001 5958396 5965557 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024927001 5958396 5965557 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01024927001 5958396 5965557 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01024877001 6302405 6311893 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024877001 6302405 6311893 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024877001 6302405 6311893 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024877001 6302405 6311893 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024877001 6302405 6311893 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024877001 6302405 6311893 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024877001 6302405 6311893 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01024877001 6302405 6311893 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01024877001 6302405 6311893 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01024877001 6302405 6311893 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024877001 6302405 6311893 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024877001 6302405 6311893 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01032165001 21901208 21926021 GSVIVG01019290001 1828181 1831512 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01019290001 1828181 1831512 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01025853001 11211240 11212586 GSVIVG01026563001 21784491 21800688 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a nucleotidyl group to a reactant. IEA GO:0016779 nucleotidyltransferase activity GSVIVG01035617001 2748489 2749818 GSVIVG01019679001 2414503 2415924 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01019679001 2414503 2415924 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01019679001 2414503 2415924 GO:0006414 translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01019679001 2414503 2415924 GO:0006414 translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01015067001 809998 811969 GSVIVG01006367001 25293945 25300234 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. IEA GO:0016836 hydro-lyase activity GSVIVG01018064001 6052180 6053937 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01018064001 6052180 6053937 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01037860001 7044854 7051148 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01037860001 7044854 7051148 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01037860001 7044854 7051148 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01029188001 18750655 18755907 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid. IEA GO:0008378 galactosyltransferase activity GSVIVG01036320001 3763678 3765886 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01036320001 3763678 3765886 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01003463001 10491883 10493615 GSVIVG01037375001 14790169 14796395 GSVIVG01036785001 22575606 22581761 GSVIVG01022207001 17462636 17465843 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01022207001 17462636 17465843 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01022207001 17462636 17465843 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01022207001 17462636 17465843 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01031544001 17324331 17351646 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031544001 17324331 17351646 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01031544001 17324331 17351646 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01035089001 1380484 1388778 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01017058001 3838244 3842000 GSVIVG01006895001 28936408 28937470 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01028281001 5457683 5458417 GSVIVG01000459001 8183982 8194299 GSVIVG01038595001 21617856 21619627 GSVIVG01034338001 17860713 17864400 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01034338001 17860713 17864400 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01034338001 17860713 17864400 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01034338001 17860713 17864400 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01002074001 32717924 32726433 GSVIVG01029189001 18745057 18746311 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid. IEA GO:0008378 galactosyltransferase activity GSVIVG01013100001 8287289 8298042 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion. IEA GO:0005484 SNAP receptor activity GSVIVG01013100001 8287289 8298042 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion. IEA GO:0005484 SNAP receptor activity GSVIVG01013100001 8287289 8298042 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion. IEA GO:0005484 SNAP receptor activity GSVIVG01013100001 8287289 8298042 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion. IEA GO:0005484 SNAP receptor activity GSVIVG01013100001 8287289 8298042 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013100001 8287289 8298042 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013100001 8287289 8298042 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013100001 8287289 8298042 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016319001 5133998 5152612 GSVIVG01038736001 145459 186383 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the random hydrolysis of 1,4-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate. IEA GO:0004415 hyalurononglucosaminidase activity GSVIVG01038736001 145459 186383 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the random hydrolysis of 1,4-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate. IEA GO:0004415 hyalurononglucosaminidase activity GSVIVG01038736001 145459 186383 GO:0007342 fusion of sperm to egg plasma membrane The binding and fusion of a sperm, having penetrated the zona pellucida, with the plasma membrane of the oocyte. Binding occurs at the posterior (post-acrosomal) region of the sperm head. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the random hydrolysis of 1,4-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate. IEA GO:0004415 hyalurononglucosaminidase activity GSVIVG01038736001 145459 186383 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of potassium ions (K+) from one side of a membrane to the other. IEA GO:0015079 potassium ion transmembrane transporter activity GSVIVG01038736001 145459 186383 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of potassium ions (K+) from one side of a membrane to the other. IEA GO:0015079 potassium ion transmembrane transporter activity GSVIVG01038736001 145459 186383 GO:0007342 fusion of sperm to egg plasma membrane The binding and fusion of a sperm, having penetrated the zona pellucida, with the plasma membrane of the oocyte. Binding occurs at the posterior (post-acrosomal) region of the sperm head. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of potassium ions (K+) from one side of a membrane to the other. IEA GO:0015079 potassium ion transmembrane transporter activity GSVIVG01038736001 145459 186383 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01038736001 145459 186383 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01038736001 145459 186383 GO:0007342 fusion of sperm to egg plasma membrane The binding and fusion of a sperm, having penetrated the zona pellucida, with the plasma membrane of the oocyte. Binding occurs at the posterior (post-acrosomal) region of the sperm head. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01019053001 17321650 17322027 GSVIVG01003600001 11150583 11155740 GSVIVG01022665001 14313417 14314479 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01016595001 2540169 2544404 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01016595001 2540169 2544404 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01016595001 2540169 2544404 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01034321001 14822182 14823037 GSVIVG01011286001 10639774 10643745 GSVIVG01005916001 22625437 22632092 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01034252001 13494306 13496903 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01034252001 13494306 13496903 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01034252001 13494306 13496903 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034252001 13494306 13496903 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034252001 13494306 13496903 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01034252001 13494306 13496903 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01020506001 18240229 18240658 GSVIVG01027900001 9178946 9184983 GO:0030833 regulation of actin filament polymerization Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament. IEA GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA GSVIVG01014020001 9058542 9074082 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014020001 9058542 9074082 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014020001 9058542 9074082 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014020001 9058542 9074082 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014020001 9058542 9074082 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014020001 9058542 9074082 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014020001 9058542 9074082 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014020001 9058542 9074082 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014020001 9058542 9074082 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014020001 9058542 9074082 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01014020001 9058542 9074082 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01014020001 9058542 9074082 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01014020001 9058542 9074082 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014020001 9058542 9074082 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014020001 9058542 9074082 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009957001 12821112 12823055 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01032583001 28573089 28578159 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005667 transcription factor complex A protein complex, distinct from RNA polymerase, that associates with DNA at promoters or at cis-acting regulatory sequences, by direct binding or by interaction with other DNA-binding polypeptides or complexes, and regulates transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01026673001 4604899 4611593 GO:0006904 vesicle docking involved in exocytosis The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis. IEA GSVIVG01026673001 4604899 4611593 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GSVIVG01000943001 22115841 22118070 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0005839 proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. IEA Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. IEA GO:0004298 threonine-type endopeptidase activity GSVIVG01034854001 22766637 22767234 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01034854001 22766637 22767234 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01019758001 3047426 3049549 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01019758001 3047426 3049549 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01019758001 3047426 3049549 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01019758001 3047426 3049549 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01019758001 3047426 3049549 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01019758001 3047426 3049549 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01019758001 3047426 3049549 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01019758001 3047426 3049549 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01019758001 3047426 3049549 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01019758001 3047426 3049549 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01019758001 3047426 3049549 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01019758001 3047426 3049549 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01019758001 3047426 3049549 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01019758001 3047426 3049549 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01019758001 3047426 3049549 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01019758001 3047426 3049549 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01019758001 3047426 3049549 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01019758001 3047426 3049549 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01019758001 3047426 3049549 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01019758001 3047426 3049549 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01019758001 3047426 3049549 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01019758001 3047426 3049549 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01019758001 3047426 3049549 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01019758001 3047426 3049549 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01019758001 3047426 3049549 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01019758001 3047426 3049549 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01019758001 3047426 3049549 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01017044001 3727295 3742376 GO:0016070 RNA metabolic process The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01017044001 3727295 3742376 GO:0016070 RNA metabolic process The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01013253001 6199955 6208988 GSVIVG01010753001 22185875 22200029 GSVIVG01015083001 916898 920012 GSVIVG01005222001 19418848 19420364 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01005222001 19418848 19420364 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01005222001 19418848 19420364 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01005222001 19418848 19420364 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011519001 13235350 13237726 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. IEA GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GSVIVG01033642001 19010265 19017959 GSVIVG01035704001 3466051 3471214 GSVIVG01029203001 18581095 18582411 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029203001 18581095 18582411 GO:0048193 Golgi vesicle transport The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01024297001 627483 628189 GO:0006413 translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. IEA GO:0005852 eukaryotic translation initiation factor 3 complex A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs. IEA Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. IEA GO:0003743 translation initiation factor activity GSVIVG01022698001 15210356 15211955 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01016597001 2523623 2532887 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the reaction: 2-oxoglutarate + lipoamide = S-succinyldihydrolipoamide + CO2. IEA GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity GSVIVG01016597001 2523623 2532887 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2-oxoglutarate + lipoamide = S-succinyldihydrolipoamide + CO2. IEA GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity GSVIVG01016597001 2523623 2532887 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide. IEA GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor GSVIVG01016597001 2523623 2532887 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide. IEA GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor GSVIVG01016597001 2523623 2532887 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Interacting selectively and non-covalently with thiamin pyrophosphate, the diphosphoric ester of thiamin. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases. IEA GO:0030976 thiamin pyrophosphate binding GSVIVG01016597001 2523623 2532887 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with thiamin pyrophosphate, the diphosphoric ester of thiamin. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases. IEA GO:0030976 thiamin pyrophosphate binding GSVIVG01016012001 17316782 17334947 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01038465001 9745731 9750978 GSVIVG01034789001 21687840 21692058 GSVIVG01018241001 12692307 12692737 GSVIVG01001317001 5258569 5261179 The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01018933001 18551004 18557058 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012671001 503092 507420 GSVIVG01035815001 4580991 4585068 GO:0005740 mitochondrial envelope The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O. IEA GO:0004129 cytochrome-c oxidase activity GSVIVG01035033001 1049338 1054356 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01025519001 5645 7247 GSVIVG01004265001 37825787 37827015 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01028130001 4045841 4055169 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01016331001 4971058 4972252 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01016331001 4971058 4972252 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01037132001 28781440 28786756 GSVIVG01022121001 16746616 16749211 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion. IEA GO:0004806 triglyceride lipase activity GSVIVG01001463001 21197007 21207343 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001463001 21197007 21207343 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001463001 21197007 21207343 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001463001 21197007 21207343 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001463001 21197007 21207343 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001463001 21197007 21207343 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001463001 21197007 21207343 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001463001 21197007 21207343 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001463001 21197007 21207343 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001463001 21197007 21207343 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001463001 21197007 21207343 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+. IEA GO:0004367 glycerol-3-phosphate dehydrogenase (NAD+) activity GSVIVG01001463001 21197007 21207343 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+. IEA GO:0004367 glycerol-3-phosphate dehydrogenase (NAD+) activity GSVIVG01001463001 21197007 21207343 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+. IEA GO:0004367 glycerol-3-phosphate dehydrogenase (NAD+) activity GSVIVG01001463001 21197007 21207343 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+. IEA GO:0004367 glycerol-3-phosphate dehydrogenase (NAD+) activity GSVIVG01001463001 21197007 21207343 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+. IEA GO:0004367 glycerol-3-phosphate dehydrogenase (NAD+) activity GSVIVG01001463001 21197007 21207343 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+. IEA GO:0004367 glycerol-3-phosphate dehydrogenase (NAD+) activity GSVIVG01001463001 21197007 21207343 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+. IEA GO:0004367 glycerol-3-phosphate dehydrogenase (NAD+) activity GSVIVG01001463001 21197007 21207343 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+. IEA GO:0004367 glycerol-3-phosphate dehydrogenase (NAD+) activity GSVIVG01001463001 21197007 21207343 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+. IEA GO:0004367 glycerol-3-phosphate dehydrogenase (NAD+) activity GSVIVG01001463001 21197007 21207343 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+. IEA GO:0004367 glycerol-3-phosphate dehydrogenase (NAD+) activity GSVIVG01001463001 21197007 21207343 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01001463001 21197007 21207343 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01001463001 21197007 21207343 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01001463001 21197007 21207343 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01001463001 21197007 21207343 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01001463001 21197007 21207343 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01001463001 21197007 21207343 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01001463001 21197007 21207343 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01001463001 21197007 21207343 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01001463001 21197007 21207343 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01001463001 21197007 21207343 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001463001 21197007 21207343 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001463001 21197007 21207343 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001463001 21197007 21207343 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001463001 21197007 21207343 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001463001 21197007 21207343 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001463001 21197007 21207343 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001463001 21197007 21207343 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001463001 21197007 21207343 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001463001 21197007 21207343 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001463001 21197007 21207343 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GSVIVG01001463001 21197007 21207343 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GSVIVG01001463001 21197007 21207343 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GSVIVG01001463001 21197007 21207343 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GSVIVG01001463001 21197007 21207343 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GSVIVG01001463001 21197007 21207343 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GSVIVG01001463001 21197007 21207343 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GSVIVG01001463001 21197007 21207343 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GSVIVG01001463001 21197007 21207343 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GSVIVG01001463001 21197007 21207343 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GSVIVG01001463001 21197007 21207343 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01001463001 21197007 21207343 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01001463001 21197007 21207343 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01001463001 21197007 21207343 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01001463001 21197007 21207343 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01001463001 21197007 21207343 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01001463001 21197007 21207343 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01001463001 21197007 21207343 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01001463001 21197007 21207343 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01001463001 21197007 21207343 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01001463001 21197007 21207343 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01001463001 21197007 21207343 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01001463001 21197007 21207343 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01001463001 21197007 21207343 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01001463001 21197007 21207343 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01001463001 21197007 21207343 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01001463001 21197007 21207343 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01001463001 21197007 21207343 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01001463001 21197007 21207343 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01001463001 21197007 21207343 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01001463001 21197007 21207343 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01001463001 21197007 21207343 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01001463001 21197007 21207343 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01001463001 21197007 21207343 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01001463001 21197007 21207343 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01001463001 21197007 21207343 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01001463001 21197007 21207343 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01001463001 21197007 21207343 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01001463001 21197007 21207343 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01001463001 21197007 21207343 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01037286001 16481600 16484971 GSVIVG01016906001 2442601 2451690 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01016906001 2442601 2451690 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01016906001 2442601 2451690 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end. IEA GO:0008408 3'-5' exonuclease activity GSVIVG01023899001 2591511 2593945 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01023899001 2591511 2593945 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01023899001 2591511 2593945 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01023899001 2591511 2593945 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01002386001 948363 958053 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. IEA GO:0008080 N-acetyltransferase activity GSVIVG01002386001 948363 958053 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. IEA GO:0008080 N-acetyltransferase activity GSVIVG01031833001 4768405 4769397 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010076001 14903168 14903422 GSVIVG01014037001 9543759 9549773 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014037001 9543759 9549773 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014037001 9543759 9549773 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014037001 9543759 9549773 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014037001 9543759 9549773 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008025001 6556968 6562182 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01021402001 4938276 4941787 GSVIVG01021058001 14352480 14355765 GSVIVG01032312001 14981524 14982512 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GSVIVG01032119001 22499777 22501242 GSVIVG01006458001 26141072 26143521 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01006458001 26141072 26143521 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01006458001 26141072 26143521 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01006458001 26141072 26143521 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01006458001 26141072 26143521 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01006458001 26141072 26143521 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01006458001 26141072 26143521 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01006458001 26141072 26143521 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008612001 419129 419605 GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. IEA GO:0005179 hormone activity GSVIVG01011680001 5171670 5272861 GSVIVG01011173001 7721297 7737698 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01026267001 15163112 15163453 GO:0006414 translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01026267001 15163112 15163453 GO:0006414 translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01016757001 1010055 1040829 GSVIVG01015499001 4243191 4244517 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01012199001 599213 602915 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01012199001 599213 602915 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01003459001 10438740 10441571 GSVIVG01018165001 13708127 13710873 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01010980001 2452262 2460607 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01010980001 2452262 2460607 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01013872001 5725665 5733206 GSVIVG01024617001 8375506 8377271 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01033943001 16460955 16498376 GSVIVG01028692001 19798195 19798566 GSVIVG01015417001 3458689 3460509 GSVIVG01013612001 1429686 1453826 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01013612001 1429686 1453826 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01013612001 1429686 1453826 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01013612001 1429686 1453826 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013612001 1429686 1453826 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024481001 3124001 3127389 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024481001 3124001 3127389 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024481001 3124001 3127389 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024481001 3124001 3127389 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the reaction: L-glutamate + H2O + NAD+ = 2-oxoglutarate + NH3 + NADH + H+. IEA GO:0004352 glutamate dehydrogenase activity GSVIVG01024481001 3124001 3127389 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: L-glutamate + H2O + NAD+ = 2-oxoglutarate + NH3 + NADH + H+. IEA GO:0004352 glutamate dehydrogenase activity GSVIVG01024481001 3124001 3127389 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: L-glutamate + H2O + NAD+ = 2-oxoglutarate + NH3 + NADH + H+. IEA GO:0004352 glutamate dehydrogenase activity GSVIVG01024481001 3124001 3127389 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the reaction: L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+. IEA GO:0004353 glutamate dehydrogenase [NAD(P)+] activity GSVIVG01024481001 3124001 3127389 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+. IEA GO:0004353 glutamate dehydrogenase [NAD(P)+] activity GSVIVG01024481001 3124001 3127389 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+. IEA GO:0004353 glutamate dehydrogenase [NAD(P)+] activity GSVIVG01024481001 3124001 3127389 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024481001 3124001 3127389 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024481001 3124001 3127389 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024481001 3124001 3127389 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024481001 3124001 3127389 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024481001 3124001 3127389 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024481001 3124001 3127389 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor GSVIVG01024481001 3124001 3127389 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor GSVIVG01024481001 3124001 3127389 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor GSVIVG01007539001 12494826 12498377 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01032299001 14760595 14762110 GSVIVG01013430001 524837 530439 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01013430001 524837 530439 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01000477001 14523826 14525599 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01000477001 14523826 14525599 Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. IEA GO:0008171 O-methyltransferase activity GSVIVG01000477001 14523826 14525599 The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01022237001 17754385 17757852 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01022237001 17754385 17757852 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01022237001 17754385 17757852 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01022237001 17754385 17757852 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01023118001 22382401 22384047 GSVIVG01007183001 30687682 30688881 GSVIVG01023984001 1917760 1921426 GSVIVG01018336001 10868314 10879047 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01032681001 1578645 1580497 GO:0009664 plant-type cell wall organization A process that results in the assembly and arrangement of constituent parts of the cellulose and pectin-containing cell wall, or in the disassembly of the cellulose and pectin-containing cell wall. This process is carried out at the cellular level. An example of this process is found in Arabidopsis thaliana. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA GSVIVG01032681001 1578645 1580497 GO:0009664 plant-type cell wall organization A process that results in the assembly and arrangement of constituent parts of the cellulose and pectin-containing cell wall, or in the disassembly of the cellulose and pectin-containing cell wall. This process is carried out at the cellular level. An example of this process is found in Arabidopsis thaliana. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01032401001 26968313 26971184 GSVIVG01030836001 17291798 17300538 GSVIVG01026443001 23600816 23604300 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022616001 13456565 13457349 GSVIVG01002062001 1275996 1277450 GSVIVG01016691001 384209 399725 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01032313001 14982522 14983202 GSVIVG01014011001 8925514 8926244 GSVIVG01038121001 23637748 23649385 GSVIVG01008824001 2485710 2489651 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01036745001 23090087 23092179 GSVIVG01008431001 2148938 2150067 GSVIVG01038059001 17210241 17211505 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. IEA GO:0004364 glutathione transferase activity GSVIVG01021208001 2552516 2553529 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01021208001 2552516 2553529 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01021208001 2552516 2553529 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01021208001 2552516 2553529 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel, where the inward rectification is due to a voltage-dependent block of the channel pore by a G protein. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. IEA GO:0015467 G-protein activated inward rectifier potassium channel activity GSVIVG01021208001 2552516 2553529 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel, where the inward rectification is due to a voltage-dependent block of the channel pore by a G protein. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. IEA GO:0015467 G-protein activated inward rectifier potassium channel activity GSVIVG01021208001 2552516 2553529 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel, where the inward rectification is due to a voltage-dependent block of the channel pore by a G protein. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. IEA GO:0015467 G-protein activated inward rectifier potassium channel activity GSVIVG01021208001 2552516 2553529 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01021208001 2552516 2553529 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01021208001 2552516 2553529 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01035284001 16202 17540 GSVIVG01022872001 18524331 18526258 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01022872001 18524331 18526258 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01035098001 1463118 1464392 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035098001 1463118 1464392 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035098001 1463118 1464392 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035098001 1463118 1464392 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01035098001 1463118 1464392 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01035098001 1463118 1464392 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01016194001 6837329 6842497 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016194001 6837329 6842497 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01016194001 6837329 6842497 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016194001 6837329 6842497 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01038227001 24480165 24489603 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01038227001 24480165 24489603 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01038227001 24480165 24489603 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01038227001 24480165 24489603 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01020753001 2333602 2339774 GSVIVG01003279001 14050225 14053743 GSVIVG01025081001 4675993 4679353 GSVIVG01004835001 5523273 5523828 GSVIVG01037297001 16313817 16316480 Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01037297001 16313817 16316480 Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01037297001 16313817 16316480 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01037297001 16313817 16316480 Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01019784001 3263715 3264065 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019784001 3263715 3264065 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019784001 3263715 3264065 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA IEA GO:0016986 transcription initiation factor activity GSVIVG01019784001 3263715 3264065 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA IEA GO:0016986 transcription initiation factor activity GSVIVG01019784001 3263715 3264065 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01019784001 3263715 3264065 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01031405001 19031497 19036516 GSVIVG01035763001 4085350 4088042 GSVIVG01014230001 1707567 1726403 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01014230001 1707567 1726403 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA Catalysis of the reaction: isopentenyl diphosphate + tRNA = diphosphate + tRNA containing 6-isopentenyladenosine. IEA GO:0004811 tRNA isopentenyltransferase activity GSVIVG01014230001 1707567 1726403 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014230001 1707567 1726403 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01031566001 18253021 18257945 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01031566001 18253021 18257945 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01031566001 18253021 18257945 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01028913001 17596768 17598908 GSVIVG01016501001 3348846 3351424 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006787001 28507629 28508033 GSVIVG01001410001 18833385 18834436 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001410001 18833385 18834436 Catalysis of the elimination of H2S or substituted H2S. IEA GO:0016846 carbon-sulfur lyase activity GSVIVG01001410001 18833385 18834436 Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01037194001 28113533 28119091 GSVIVG01018213001 13163460 13176289 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01018213001 13163460 13176289 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01018213001 13163460 13176289 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018213001 13163460 13176289 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018213001 13163460 13176289 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018213001 13163460 13176289 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018213001 13163460 13176289 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01018213001 13163460 13176289 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01000024001 2894817 2900489 GO:0006465 signal peptide processing The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell. IEA GO:0005787 signal peptidase complex A protein complex that is located in the endoplasmic reticulum membrane and cleaves the signal sequence from precursor proteins following their transport out of the cytoplasmic space. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01000024001 2894817 2900489 GO:0006465 signal peptide processing The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01001826001 26123304 26129912 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01037398001 14384496 14385187 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01021074001 14065432 14067113 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01032941001 24478682 24479739 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01020477001 18803652 18822202 GSVIVG01015960001 16187224 16273585 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01015960001 16187224 16273585 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01015960001 16187224 16273585 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01015960001 16187224 16273585 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01015960001 16187224 16273585 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015960001 16187224 16273585 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015960001 16187224 16273585 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01015960001 16187224 16273585 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01015960001 16187224 16273585 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01015960001 16187224 16273585 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01015960001 16187224 16273585 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01015960001 16187224 16273585 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01015960001 16187224 16273585 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01015960001 16187224 16273585 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01003154001 6179625 6179759 GSVIVG01029131001 19300918 19306485 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01029131001 19300918 19306485 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01029131001 19300918 19306485 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01029131001 19300918 19306485 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01004442001 38591234 38591760 GSVIVG01031427001 18703299 18720781 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01031427001 18703299 18720781 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01031427001 18703299 18720781 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01031427001 18703299 18720781 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008286001 3638194 3654846 GSVIVG01015419001 3485719 3493968 GO:0032312 regulation of ARF GTPase activity Any process that modulates the activity of the GTPase ARF. IEA Increases the rate of GTP hydrolysis by the GTPase ARF. IEA GO:0008060 ARF GTPase activator activity GSVIVG01015419001 3485719 3493968 GO:0032312 regulation of ARF GTPase activity Any process that modulates the activity of the GTPase ARF. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01015408001 3358818 3363084 GO:0032012 regulation of ARF protein signal transduction Any process that modulates the frequency, rate or extent of ARF protein signal transduction. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Stimulates the exchange of guanyl nucleotides associated with the GTPase ARF. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. IEA GO:0005086 ARF guanyl-nucleotide exchange factor activity GSVIVG01015408001 3358818 3363084 GO:0032012 regulation of ARF protein signal transduction Any process that modulates the frequency, rate or extent of ARF protein signal transduction. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01029897001 1081745 1107253 GSVIVG01017347001 7022348 7033478 GSVIVG01019346001 718767 719284 GSVIVG01016971001 3062299 3071223 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016971001 3062299 3071223 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016971001 3062299 3071223 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: ATP + D-hexose = ADP + D-hexose 6-phosphate. IEA GO:0004396 hexokinase activity GSVIVG01016971001 3062299 3071223 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the reaction: ATP + D-hexose = ADP + D-hexose 6-phosphate. IEA GO:0004396 hexokinase activity GSVIVG01016971001 3062299 3071223 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016971001 3062299 3071223 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016971001 3062299 3071223 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01016971001 3062299 3071223 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01016971001 3062299 3071223 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01016971001 3062299 3071223 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01016971001 3062299 3071223 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01016971001 3062299 3071223 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01005231001 19576521 19576712 GSVIVG01010478001 20933417 20934933 GO:0007067 mitosis A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell. IEA GSVIVG01003941001 8224482 8229313 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01003941001 8224482 8229313 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003941001 8224482 8229313 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01030635001 7338801 7343377 GSVIVG01017200001 5271845 5280516 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01011661001 5451233 5476280 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005643 nuclear pore Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined. IEA The action of a molecule that contributes to the structural integrity of the nuclear pore complex. IEA GO:0017056 structural constituent of nuclear pore GSVIVG01003761001 12453437 12459678 GSVIVG01003106001 7288643 7289924 GSVIVG01031651001 19608327 19610244 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031651001 19608327 19610244 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031651001 19608327 19610244 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016947001 2856811 2857382 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01016947001 2856811 2857382 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01016947001 2856811 2857382 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027346001 16143332 16147309 GSVIVG01022440001 3056574 3072168 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01022440001 3056574 3072168 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01017705001 2799919 2800164 GSVIVG01009474001 8676604 8677284 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01007924001 7501796 7507663 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01007924001 7501796 7507663 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01033245001 22229041 22231587 GSVIVG01007829001 8614159 8620640 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01007829001 8614159 8620640 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001907001 7079911 7088941 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01026816001 20286421 20300649 GSVIVG01027012001 18574235 18577072 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027012001 18574235 18577072 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01027012001 18574235 18577072 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01000429001 7864685 7865131 GSVIVG01010412001 20330178 20330279 GSVIVG01032818001 507025 515082 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = D-myo-inositol 1,4,5-trisphosphate + diacylglycerol. IEA GO:0004435 phosphoinositide phospholipase C activity GSVIVG01032818001 507025 515082 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = D-myo-inositol 1,4,5-trisphosphate + diacylglycerol. IEA GO:0004435 phosphoinositide phospholipase C activity GSVIVG01032818001 507025 515082 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate. IEA GO:0004629 phospholipase C activity GSVIVG01032818001 507025 515082 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate. IEA GO:0004629 phospholipase C activity GSVIVG01032818001 507025 515082 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01032818001 507025 515082 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01032818001 507025 515082 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01032818001 507025 515082 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01032818001 507025 515082 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. IEA GO:0008081 phosphoric diester hydrolase activity GSVIVG01032818001 507025 515082 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. IEA GO:0008081 phosphoric diester hydrolase activity GSVIVG01000485001 14717386 14720889 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01000485001 14717386 14720889 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01023786001 3477198 3481070 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01023786001 3477198 3481070 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the reaction: pectin + n H2O = n methanol + pectate. IEA GO:0030599 pectinesterase activity GSVIVG01023786001 3477198 3481070 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue. IEA GO:0045330 aspartyl esterase activity GSVIVG01005450001 40276726 40278597 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008009001 6714951 6715998 GSVIVG01006332001 24950558 24951511 GSVIVG01034704001 8019966 8021689 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01034704001 8019966 8021689 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01034704001 8019966 8021689 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01034704001 8019966 8021689 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01034704001 8019966 8021689 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01034704001 8019966 8021689 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01016613001 2435783 2437688 GSVIVG01031591001 18570884 18609930 GSVIVG01035051001 1183937 1188336 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01035051001 1183937 1188336 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01035051001 1183937 1188336 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01035051001 1183937 1188336 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035051001 1183937 1188336 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035051001 1183937 1188336 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01037833001 7374686 7389061 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01037833001 7374686 7389061 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01037833001 7374686 7389061 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01028297001 5863416 5868978 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033388001 21013223 21014343 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033388001 21013223 21014343 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033388001 21013223 21014343 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01034090001 15244298 15250817 GSVIVG01016574001 2679309 2684197 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016574001 2679309 2684197 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016574001 2679309 2684197 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016574001 2679309 2684197 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016574001 2679309 2684197 GO:0045226 extracellular polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016574001 2679309 2684197 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016574001 2679309 2684197 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016574001 2679309 2684197 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016574001 2679309 2684197 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016574001 2679309 2684197 GO:0045226 extracellular polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016574001 2679309 2684197 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + NADPH + H+. IEA GO:0008831 dTDP-4-dehydrorhamnose reductase activity GSVIVG01016574001 2679309 2684197 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + NADPH + H+. IEA GO:0008831 dTDP-4-dehydrorhamnose reductase activity GSVIVG01016574001 2679309 2684197 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + NADPH + H+. IEA GO:0008831 dTDP-4-dehydrorhamnose reductase activity GSVIVG01016574001 2679309 2684197 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + NADPH + H+. IEA GO:0008831 dTDP-4-dehydrorhamnose reductase activity GSVIVG01016574001 2679309 2684197 GO:0045226 extracellular polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. IEA Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + NADPH + H+. IEA GO:0008831 dTDP-4-dehydrorhamnose reductase activity GSVIVG01016574001 2679309 2684197 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. IEA GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GSVIVG01016574001 2679309 2684197 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. IEA GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GSVIVG01016574001 2679309 2684197 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. IEA GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GSVIVG01016574001 2679309 2684197 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. IEA GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GSVIVG01016574001 2679309 2684197 GO:0045226 extracellular polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. IEA Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. IEA GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GSVIVG01016574001 2679309 2684197 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01016574001 2679309 2684197 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01016574001 2679309 2684197 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01016574001 2679309 2684197 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01016574001 2679309 2684197 GO:0045226 extracellular polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01027071001 18177401 18178321 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01028924001 17450061 17472817 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025582001 13902809 13905474 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025582001 13902809 13905474 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025582001 13902809 13905474 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01025582001 13902809 13905474 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01012116001 1303636 1315494 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01012116001 1303636 1315494 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01012116001 1303636 1315494 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01012116001 1303636 1315494 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012798001 23124268 23126799 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030451001 5665642 5670120 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01008715001 1431364 1433475 GSVIVG01013580001 21138854 21161143 GO:0008643 carbohydrate transport The directed movement of carbohydrate into, out of, within or between cells by means of some external agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0000139 Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + H+(out) = sugar(in) + H+(in). IEA GO:0005351 sugar:hydrogen symporter activity GSVIVG01013580001 21138854 21161143 GO:0008643 carbohydrate transport The directed movement of carbohydrate into, out of, within or between cells by means of some external agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + H+(out) = sugar(in) + H+(in). IEA GO:0005351 sugar:hydrogen symporter activity GSVIVG01005906001 717973 733495 GSVIVG01033904001 16849091 16855163 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0008236 serine-type peptidase activity GSVIVG01029981001 2661092 2692657 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01027293001 17029283 17034454 GSVIVG01034525001 19881478 19881979 GSVIVG01032142001 22232610 22235884 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032142001 22232610 22235884 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01032142001 22232610 22235884 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01016053001 18034926 18038239 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01014428001 3653741 3655574 GSVIVG01009831001 11630815 11630958 GSVIVG01009047001 4535173 4537082 GSVIVG01018564001 13303988 13305889 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018564001 13303988 13305889 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025384001 1199805 1206412 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01025384001 1199805 1206412 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01013905001 6635678 6636951 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01013905001 6635678 6636951 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01014265001 2128359 2130017 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01028235001 4829762 4832282 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025633001 13449970 13458217 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025633001 13449970 13458217 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular peptide to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state. IEA GO:0008528 peptide receptor activity, G-protein coupled GSVIVG01015962001 16303469 16347950 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015962001 16303469 16347950 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015962001 16303469 16347950 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01015962001 16303469 16347950 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01009821001 11546246 11548336 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01030304001 9230232 9239024 GO:0006464 protein modification process The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030304001 9230232 9239024 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030304001 9230232 9239024 GO:0006464 protein modification process The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01030304001 9230232 9239024 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01030304001 9230232 9239024 GO:0006464 protein modification process The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030304001 9230232 9239024 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030304001 9230232 9239024 GO:0006464 protein modification process The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). IEA Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond. IEA GO:0008641 small protein activating enzyme activity GSVIVG01030304001 9230232 9239024 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond. IEA GO:0008641 small protein activating enzyme activity GSVIVG01036190001 9292849 9298340 GSVIVG01027967001 2874661 2875127 GSVIVG01025527001 14294207 14298285 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025527001 14294207 14298285 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01025527001 14294207 14298285 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01030207001 10435563 10435682 GSVIVG01016713001 553848 557281 GSVIVG01006444001 26044571 26050096 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01006444001 26044571 26050096 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01006444001 26044571 26050096 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01006444001 26044571 26050096 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021818001 6982910 6991189 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021818001 6982910 6991189 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021818001 6982910 6991189 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01017810001 3627458 3630257 GSVIVG01032882001 23730785 23741807 GSVIVG01028266001 5033443 5035278 Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01026832001 20115182 20118752 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026832001 20115182 20118752 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026832001 20115182 20118752 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026832001 20115182 20118752 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01026832001 20115182 20118752 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01026832001 20115182 20118752 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01026832001 20115182 20118752 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026832001 20115182 20118752 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026832001 20115182 20118752 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026832001 20115182 20118752 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01026832001 20115182 20118752 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01026832001 20115182 20118752 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01026832001 20115182 20118752 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01026832001 20115182 20118752 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01026832001 20115182 20118752 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01011149001 7312815 7340173 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GSVIVG01013578001 21125137 21127612 GSVIVG01023923001 2458653 2459552 GSVIVG01024282001 513299 519856 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01031581001 18426699 18461920 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01013966001 8032513 8033859 GSVIVG01030989001 20383479 20384410 GSVIVG01028283001 5552055 5580494 GSVIVG01026001001 26017661 26020840 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01026001001 26017661 26020840 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01026001001 26017661 26020840 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026001001 26017661 26020840 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026001001 26017661 26020840 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01026001001 26017661 26020840 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01025542001 14172550 14174772 GSVIVG01027971001 2895742 2898425 GSVIVG01000033001 2941501 2944736 GSVIVG01029456001 22658324 22659829 GSVIVG01014888001 11204754 11208099 GO:0008643 carbohydrate transport The directed movement of carbohydrate into, out of, within or between cells by means of some external agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0000139 Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + H+(out) = sugar(in) + H+(in). IEA GO:0005351 sugar:hydrogen symporter activity GSVIVG01014888001 11204754 11208099 GO:0008643 carbohydrate transport The directed movement of carbohydrate into, out of, within or between cells by means of some external agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + H+(out) = sugar(in) + H+(in). IEA GO:0005351 sugar:hydrogen symporter activity GSVIVG01031257001 743075 746614 GSVIVG01010688001 11801260 11804996 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001811001 26008182 26011003 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01001811001 26008182 26011003 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01001811001 26008182 26011003 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01001811001 26008182 26011003 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01001811001 26008182 26011003 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01001811001 26008182 26011003 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01001811001 26008182 26011003 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001811001 26008182 26011003 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020075001 10683528 10690793 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01020075001 10683528 10690793 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01015306001 2530672 2536481 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01015306001 2530672 2536481 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01015306001 2530672 2536481 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015306001 2530672 2536481 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015306001 2530672 2536481 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01015306001 2530672 2536481 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01015306001 2530672 2536481 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01015306001 2530672 2536481 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01015306001 2530672 2536481 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01015306001 2530672 2536481 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01032820001 497413 500806 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). IEA GO:0003755 peptidyl-prolyl cis-trans isomerase activity GSVIVG01010768001 22416012 22421425 GSVIVG01032540001 28180397 28187032 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: reduced ferredoxin + NAD(P)+ = oxidized ferredoxin + NAD(P)H + H+. IEA GO:0008937 ferredoxin reductase activity GSVIVG01000864001 3172541 3187103 GSVIVG01014440001 3780456 3784385 GSVIVG01011435001 29638799 29639395 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01019072001 17078980 17094658 GSVIVG01015649001 14881928 14882711 GSVIVG01035749001 3888015 3967707 GSVIVG01003584001 10965609 10966312 GSVIVG01029589001 21038775 21043063 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01029589001 21038775 21043063 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01003103001 7249621 7251713 GSVIVG01027806001 7973468 7984266 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the repair of a photoproduct resulting from ultraviolet irradiation of two adjacent pyrimidine residues in DNA. IEA GO:0003913 DNA photolyase activity GSVIVG01017749001 3124105 3131662 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01013185001 6982111 6987583 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013185001 6982111 6987583 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01038433001 12148797 12150262 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01013982001 8408247 8409256 GSVIVG01012292001 13104543 13109765 GSVIVG01036401001 4656814 4659502 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01036401001 4656814 4659502 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01036401001 4656814 4659502 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01036401001 4656814 4659502 GO:0043547 positive regulation of GTPase activity Any process that activates or increases the activity of a GTPase. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01036401001 4656814 4659502 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01036401001 4656814 4659502 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. IEA GO:0005096 GTPase activator activity GSVIVG01036401001 4656814 4659502 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. IEA GO:0005096 GTPase activator activity GSVIVG01036401001 4656814 4659502 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. IEA GO:0005096 GTPase activator activity GSVIVG01036401001 4656814 4659502 GO:0043547 positive regulation of GTPase activity Any process that activates or increases the activity of a GTPase. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. IEA GO:0005096 GTPase activator activity GSVIVG01036401001 4656814 4659502 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. IEA GO:0005096 GTPase activator activity GSVIVG01036401001 4656814 4659502 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036401001 4656814 4659502 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036401001 4656814 4659502 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036401001 4656814 4659502 GO:0043547 positive regulation of GTPase activity Any process that activates or increases the activity of a GTPase. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036401001 4656814 4659502 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036401001 4656814 4659502 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036401001 4656814 4659502 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036401001 4656814 4659502 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036401001 4656814 4659502 GO:0043547 positive regulation of GTPase activity Any process that activates or increases the activity of a GTPase. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036401001 4656814 4659502 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030242001 9966775 9968283 GSVIVG01012148001 1049293 1049640 GSVIVG01035508001 1889358 1895999 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035508001 1889358 1895999 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01022771001 16326975 16335400 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01022771001 16326975 16335400 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01022771001 16326975 16335400 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01022771001 16326975 16335400 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037969001 11816720 11821771 GSVIVG01031104001 2261167 2261915 GSVIVG01027978001 2932251 2934023 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01026061001 25094567 25094859 GSVIVG01036148001 20064640 20067730 GSVIVG01020955001 16452017 16453936 GSVIVG01010278001 18797581 18798005 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01010278001 18797581 18798005 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01010278001 18797581 18798005 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01010278001 18797581 18798005 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01032543001 28209116 28215826 Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0010181 FMN binding GSVIVG01003235001 8029023 8030061 GSVIVG01020964001 16266732 16270755 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020964001 16266732 16270755 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020964001 16266732 16270755 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020964001 16266732 16270755 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020964001 16266732 16270755 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020964001 16266732 16270755 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020964001 16266732 16270755 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01020964001 16266732 16270755 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01020964001 16266732 16270755 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01020964001 16266732 16270755 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01013901001 6538759 6540125 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01013901001 6538759 6540125 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01025263001 2605295 2609437 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01025263001 2605295 2609437 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01026893001 19599871 19604217 GSVIVG01002819001 36773174 36776858 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01002819001 36773174 36776858 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01002819001 36773174 36776858 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01012581001 4251316 4252758 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01023558001 9698522 9699325 GSVIVG01023275001 20234010 20248532 GO:0000105 histidine biosynthetic process The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01023275001 20234010 20248532 GO:0000105 histidine biosynthetic process The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: 1-(5-phospho-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate. IEA GO:0003879 ATP phosphoribosyltransferase activity GSVIVG01018857001 19189233 19194277 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01018857001 19189233 19194277 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01018857001 19189233 19194277 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01018857001 19189233 19194277 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01014362001 3020095 3021255 GO:0009664 plant-type cell wall organization A process that results in the assembly and arrangement of constituent parts of the cellulose and pectin-containing cell wall, or in the disassembly of the cellulose and pectin-containing cell wall. This process is carried out at the cellular level. An example of this process is found in Arabidopsis thaliana. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA GSVIVG01003190001 7738986 7744495 GSVIVG01029776001 14512960 14514223 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01029776001 14512960 14514223 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01029776001 14512960 14514223 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01029776001 14512960 14514223 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01000460001 8194787 8196033 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01003826001 20462869 20473622 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: 3-alpha(S)-strictosidine = tryptamine + secologanin. IEA GO:0016844 strictosidine synthase activity GSVIVG01035682001 3287094 3289106 GSVIVG01033167001 8856567 8866591 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01033167001 8856567 8866591 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01033167001 8856567 8866591 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01033167001 8856567 8866591 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01023850001 2985909 2990105 GSVIVG01015033001 603939 606753 GSVIVG01022581001 5409239 5410444 GSVIVG01021486001 6057767 6065135 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000026001 2909591 2909934 GSVIVG01033339001 21361182 21366034 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01033339001 21361182 21366034 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01025626001 13492242 13495566 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01025626001 13492242 13495566 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01025626001 13492242 13495566 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015935 small ribosomal subunit The smaller of the two subunits of a ribosome. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01013358001 993191 996439 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003358001 9328338 9336802 GSVIVG01034740001 8809898 8817438 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01033960001 16287096 16290470 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01033960001 16287096 16290470 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01009566001 9477475 9483122 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01031529001 17493089 17498594 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01031529001 17493089 17498594 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031529001 17493089 17498594 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01031529001 17493089 17498594 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01018031001 5692344 5695265 GSVIVG01035283001 2349 12360 GSVIVG01020851001 1102393 1105236 GSVIVG01000554001 7141955 7167132 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01000554001 7141955 7167132 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01000554001 7141955 7167132 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01000554001 7141955 7167132 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01000554001 7141955 7167132 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000554001 7141955 7167132 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000554001 7141955 7167132 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01000554001 7141955 7167132 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01000554001 7141955 7167132 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01000554001 7141955 7167132 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01000554001 7141955 7167132 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000554001 7141955 7167132 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000554001 7141955 7167132 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01000554001 7141955 7167132 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01000554001 7141955 7167132 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01000554001 7141955 7167132 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01014331001 2716633 2720479 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar. IEA GO:0008375 acetylglucosaminyltransferase activity GSVIVG01013674001 2411588 2414732 GSVIVG01025681001 12986504 12988076 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01009299001 7086633 7089964 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009299001 7086633 7089964 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. IEA GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GSVIVG01030290001 9434299 9437790 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01030290001 9434299 9437790 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01030377001 5102905 5105970 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030377001 5102905 5105970 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain. IEA GO:0004177 aminopeptidase activity GSVIVG01013201001 6802673 6802882 GSVIVG01012030001 2041854 2062434 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01012030001 2041854 2062434 GO:0006419 alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01012030001 2041854 2062434 GO:0043039 tRNA aminoacylation The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01012030001 2041854 2062434 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01012030001 2041854 2062434 GO:0006419 alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01012030001 2041854 2062434 GO:0043039 tRNA aminoacylation The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01012030001 2041854 2062434 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala). IEA GO:0004813 alanine-tRNA ligase activity GSVIVG01012030001 2041854 2062434 GO:0006419 alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala). IEA GO:0004813 alanine-tRNA ligase activity GSVIVG01012030001 2041854 2062434 GO:0043039 tRNA aminoacylation The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala). IEA GO:0004813 alanine-tRNA ligase activity GSVIVG01012030001 2041854 2062434 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012030001 2041854 2062434 GO:0006419 alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012030001 2041854 2062434 GO:0043039 tRNA aminoacylation The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012030001 2041854 2062434 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances via a carbon-oxygen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate, to form aminoacyl-tRNA or a related compound. IEA GO:0016876 ligase activity, forming aminoacyl-tRNA and related compounds GSVIVG01012030001 2041854 2062434 GO:0006419 alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances via a carbon-oxygen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate, to form aminoacyl-tRNA or a related compound. IEA GO:0016876 ligase activity, forming aminoacyl-tRNA and related compounds GSVIVG01012030001 2041854 2062434 GO:0043039 tRNA aminoacylation The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances via a carbon-oxygen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate, to form aminoacyl-tRNA or a related compound. IEA GO:0016876 ligase activity, forming aminoacyl-tRNA and related compounds GSVIVG01013151001 7535738 7537278 GSVIVG01007942001 7311996 7316054 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01007942001 7311996 7316054 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01030910001 18864673 18872817 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01012175001 762706 763140 GSVIVG01023527001 10271664 10279050 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019035001 17528926 17530608 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01007703001 10201724 10209064 GSVIVG01036553001 23391103 23396928 GSVIVG01014203001 1427252 1429656 GSVIVG01032677001 1593175 1597738 GO:0009405 pathogenesis The set of specific processes that generate the ability of an organism to cause disease in another. IEA GO:0009289 pilus A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter. IEA GSVIVG01036471001 22474094 22475198 GSVIVG01025641001 13402660 13410174 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01025641001 13402660 13410174 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01025641001 13402660 13410174 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025641001 13402660 13410174 Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01025641001 13402660 13410174 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01012208001 558161 562819 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01012208001 558161 562819 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0043189 H4/H2A histone acetyltransferase complex A multisubunit complex that catalyzes the acetylation of histones H4 and H2A. IEA GSVIVG01020843001 1169235 1173327 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029225001 18325314 18351277 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004185 serine-type carboxypeptidase activity GSVIVG01025797001 11772947 11774152 GSVIVG01021548001 6907829 6924033 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01028154001 4259454 4262783 GSVIVG01017855001 4056169 4060179 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01006751001 28069148 28071263 GSVIVG01019368001 265767 267233 GSVIVG01032285001 14529121 14586289 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032285001 14529121 14586289 Catalysis of the transfer of a functional group from one position to another within a single molecule. IEA GO:0016866 intramolecular transferase activity GSVIVG01025855001 11202754 11205672 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01025855001 11202754 11205672 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01012106001 1418372 1422376 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01016968001 3040982 3042326 GSVIVG01028261001 5011626 5013015 GSVIVG01028640001 11461362 11464950 GO:0007050 cell cycle arrest The process by which the cell cycle is halted during one of the normal phases (G1, S, G2, M). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Stops, prevents or reduces the activity of a cyclin-dependent protein kinase. IEA GO:0004861 cyclin-dependent protein kinase inhibitor activity GSVIVG01023498001 10935630 10936479 GSVIVG01016213001 6540306 6553298 GSVIVG01037169001 28356404 28357616 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01037169001 28356404 28357616 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01028847001 18110667 18124050 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01008120001 5628041 5629396 GSVIVG01038076001 17498253 17500391 GSVIVG01031355001 94281 98722 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01031355001 94281 98722 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01031355001 94281 98722 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01031355001 94281 98722 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01019110001 16649310 16652943 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01012216001 498867 500438 GSVIVG01035255001 11494435 11499618 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01009302001 7107577 7146936 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01008725001 1461041 1462318 GO:0006821 chloride transport The directed movement of chloride into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a chloride ion by a voltage-gated channel. IEA GO:0005247 voltage-gated chloride channel activity GSVIVG01003244001 8265608 8268161 GSVIVG01027765001 7495529 7497645 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0008076 voltage-gated potassium channel complex A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. IEA Interacting selectively and non-covalently with the sevenless (sev) protein, a receptor tyrosine kinase. IEA GO:0005118 sevenless binding GSVIVG01027765001 7495529 7497645 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with the sevenless (sev) protein, a receptor tyrosine kinase. IEA GO:0005118 sevenless binding GSVIVG01027765001 7495529 7497645 GO:0007601 visual perception The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image. IEA GO:0008076 voltage-gated potassium channel complex A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. IEA Interacting selectively and non-covalently with the sevenless (sev) protein, a receptor tyrosine kinase. IEA GO:0005118 sevenless binding GSVIVG01027765001 7495529 7497645 GO:0007601 visual perception The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with the sevenless (sev) protein, a receptor tyrosine kinase. IEA GO:0005118 sevenless binding GSVIVG01027765001 7495529 7497645 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0008076 voltage-gated potassium channel complex A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01027765001 7495529 7497645 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01027765001 7495529 7497645 GO:0007601 visual perception The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image. IEA GO:0008076 voltage-gated potassium channel complex A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01027765001 7495529 7497645 GO:0007601 visual perception The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01022940001 17785067 17797890 GSVIVG01033575001 19625711 19635107 GSVIVG01009467001 8609031 8612826 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01014843001 10490145 10498164 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01014843001 10490145 10498164 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01010567001 16528780 16543995 GSVIVG01026839001 20073492 20073575 GSVIVG01011539001 12800307 12817428 GSVIVG01010908001 15823192 15870866 GSVIVG01005384001 40052841 40056052 GSVIVG01001247001 4494381 4504754 GSVIVG01037518001 12340022 12351566 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020360001 20593527 20595940 GSVIVG01037890001 6660500 6667636 GSVIVG01030247001 9910681 9912449 GSVIVG01003777001 12546361 12550675 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GSVIVG01020599001 3940088 3944242 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020599001 3940088 3944242 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01017834001 3870662 3884456 GSVIVG01010604001 16113212 16117083 GSVIVG01000555001 7122077 7137723 GSVIVG01016963001 3011803 3014257 GSVIVG01026092001 24653600 24658199 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01026092001 24653600 24658199 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000514001 13407870 13455264 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01000514001 13407870 13455264 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01000514001 13407870 13455264 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023110001 22457882 22461088 GO:0009072 aromatic amino acid family metabolic process The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01017993001 5318274 5333813 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012648001 340675 344914 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01012648001 340675 344914 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01012648001 340675 344914 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01012648001 340675 344914 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01018929001 18570542 18574335 Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01031975001 5845678 5849261 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01013653001 1998633 1999319 GSVIVG01002205001 206778 209922 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01002205001 206778 209922 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01002205001 206778 209922 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01002205001 206778 209922 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001306001 5173996 5175801 GSVIVG01024832001 6562763 6571576 GO:0006626 protein targeting to mitochondrion The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein. IEA GO:0042719 mitochondrial intermembrane space protein transporter complex Soluble complex of the mitochondrial intermembrane space composed of various combinations of small Tim proteins; acts as a protein transporter to guide proteins to the Tim22 complex for insertion into the mitochondrial inner membrane. IEA GSVIVG01024832001 6562763 6571576 GO:0045039 protein import into mitochondrial inner membrane The import of proteins into the mitochondria inner membrane. Inner membrane proteins are first imported into the matrix space where the matrix-targeting sequence is removed; how these proteins then are incorporated into the inner membrane is not known. IEA GO:0042719 mitochondrial intermembrane space protein transporter complex Soluble complex of the mitochondrial intermembrane space composed of various combinations of small Tim proteins; acts as a protein transporter to guide proteins to the Tim22 complex for insertion into the mitochondrial inner membrane. IEA GSVIVG01030214001 10373570 10377545 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA GO:0005764 lysosome A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. IEA GSVIVG01030214001 10373570 10377545 GO:0006665 sphingolipid metabolic process The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). IEA GO:0005764 lysosome A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. IEA GSVIVG01009462001 8563884 8564847 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01033970001 16208622 16211313 GSVIVG01031582001 18465143 18465277 GSVIVG01031245001 856429 861262 GSVIVG01009914001 12339225 12341049 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01009914001 12339225 12341049 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01009914001 12339225 12341049 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01009914001 12339225 12341049 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01009914001 12339225 12341049 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01009914001 12339225 12341049 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01009914001 12339225 12341049 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01009914001 12339225 12341049 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01009914001 12339225 12341049 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01009914001 12339225 12341049 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01009914001 12339225 12341049 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01009914001 12339225 12341049 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01031813001 4640645 4641895 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032201001 21591064 21596265 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01024947001 5783783 5800541 GO:0006614 SRP-dependent cotranslational protein targeting to membrane The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. IEA GO:0048500 signal recognition particle A complex of protein and RNA which facilitates translocation of proteins across membranes. IEA Interacting selectively and non-covalently with 7S RNA, the RNA component of the signal recognition particle (SRP). IEA GO:0008312 7S RNA binding GSVIVG01023450001 11684197 11685092 GSVIVG01029626001 20518375 20527489 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01029626001 20518375 20527489 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01037845001 7195863 7206255 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01037209001 27960813 27964979 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01037209001 27960813 27964979 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01008135001 5506360 5512212 GSVIVG01012117001 1272689 1293994 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01012117001 1272689 1293994 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01012117001 1272689 1293994 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012117001 1272689 1293994 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012117001 1272689 1293994 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Interacting selectively and non-covalently with chromatin, the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase. IEA GO:0003682 chromatin binding GSVIVG01012117001 1272689 1293994 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with chromatin, the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase. IEA GO:0003682 chromatin binding GSVIVG01012117001 1272689 1293994 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01012117001 1272689 1293994 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01012117001 1272689 1293994 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012117001 1272689 1293994 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012117001 1272689 1293994 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012117001 1272689 1293994 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012117001 1272689 1293994 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01012117001 1272689 1293994 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01007138001 30328289 30342452 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01007138001 30328289 30342452 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01007138001 30328289 30342452 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01007138001 30328289 30342452 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01007138001 30328289 30342452 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01007138001 30328289 30342452 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01007138001 30328289 30342452 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007138001 30328289 30342452 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033011001 25056440 25061577 GSVIVG01024570001 8784358 8784933 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01020870001 759588 766986 GSVIVG01022050001 3697434 3698110 GSVIVG01037044001 8426971 8430834 GSVIVG01036005001 7015912 7025331 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01036005001 7015912 7025331 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01028677001 12007013 12026015 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01015199001 1768056 1773663 GSVIVG01004261001 37808389 37810610 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01015919001 15122749 15125669 GSVIVG01030571001 6838606 6838800 GSVIVG01034933001 223492 233735 GSVIVG01027907001 9227788 9230583 GO:0016568 chromatin modification The alteration of DNA or protein in chromatin, which may result in changing the chromatin structure. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01027907001 9227788 9230583 GO:0016568 chromatin modification The alteration of DNA or protein in chromatin, which may result in changing the chromatin structure. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives. IEA GO:0018024 histone-lysine N-methyltransferase activity GSVIVG01029619001 20652043 20656745 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013974001 8196198 8231928 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01007793001 8971971 8977390 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01007793001 8971971 8977390 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01007793001 8971971 8977390 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01007793001 8971971 8977390 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01007793001 8971971 8977390 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007793001 8971971 8977390 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01019921001 4469981 4478285 GSVIVG01010968001 2528621 2541552 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01010968001 2528621 2541552 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01011733001 4722596 4723256 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GSVIVG01011733001 4722596 4723256 GO:0009607 response to biotic stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism. IEA GSVIVG01013086001 8468972 8483353 Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor. IEA GO:0003950 NAD+ ADP-ribosyltransferase activity GSVIVG01017183001 5095102 5096728 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01017183001 5095102 5096728 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01035263001 11595050 11598012 GSVIVG01029980001 2654151 2659935 GSVIVG01032990001 24919663 24932902 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032990001 24919663 24932902 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01032394001 26922234 26927737 GSVIVG01038289001 24999068 24999172 GSVIVG01015087001 936025 937818 GSVIVG01031832001 4762346 4762540 GSVIVG01003413001 14762359 14765617 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01003413001 14762359 14765617 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003413001 14762359 14765617 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01003413001 14762359 14765617 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01007827001 8629208 8646306 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01007827001 8629208 8646306 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01034237001 13242474 13257290 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. IEA GO:0004618 phosphoglycerate kinase activity GSVIVG01034237001 13242474 13257290 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. IEA GO:0004618 phosphoglycerate kinase activity GSVIVG01034237001 13242474 13257290 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01034237001 13242474 13257290 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01007800001 8898831 8901421 GSVIVG01010449001 20703720 20708466 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01010449001 20703720 20708466 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01010449001 20703720 20708466 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015934 large ribosomal subunit The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01010449001 20703720 20708466 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01005714001 21499518 21517972 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01005714001 21499518 21517972 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01005714001 21499518 21517972 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01005714001 21499518 21517972 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01005714001 21499518 21517972 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01005714001 21499518 21517972 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01005714001 21499518 21517972 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01005714001 21499518 21517972 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01005714001 21499518 21517972 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01005714001 21499518 21517972 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01005714001 21499518 21517972 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01005714001 21499518 21517972 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01029232001 18230306 18248714 GSVIVG01029221001 18374490 18375554 GO:0015977 carbon fixation A metabolic process in which carbon (usually derived from carbon dioxide) is incorporated into organic compounds (usually carbohydrates). IEA Catalysis of the reaction: D-ribulose 1,5-bisphosphate + CO2 + H2O = 2 3-phospho-D-glycerate. IEA GO:0016984 ribulose-bisphosphate carboxylase activity GSVIVG01003818001 404625 405681 GSVIVG01014692001 8691935 8704283 GSVIVG01031942001 5580252 5581364 GSVIVG01005709001 21428691 21438968 GSVIVG01006575001 26535295 26569957 GSVIVG01030380001 5114914 5117533 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01006318001 24867703 24869381 GSVIVG01033006001 25023672 25028122 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033180 proton-transporting V-type ATPase, V1 domain A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01008938001 3594893 3606331 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01008938001 3594893 3606331 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01008938001 3594893 3606331 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01008938001 3594893 3606331 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008795001 2150109 2166350 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01008795001 2150109 2166350 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01034498001 20311699 20316360 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01034498001 20311699 20316360 Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. IEA GO:0008171 O-methyltransferase activity GSVIVG01034498001 20311699 20316360 The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01035369001 833252 838822 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035369001 833252 838822 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01021034001 14976881 14979821 GSVIVG01008243001 4191395 4195089 GSVIVG01002224001 33526468 33548029 GSVIVG01007029001 29801784 29809197 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01007029001 29801784 29809197 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01007029001 29801784 29809197 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007029001 29801784 29809197 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010552001 16717905 16718516 GSVIVG01035135001 1771676 1772123 GSVIVG01017924001 4744436 4746762 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01036482001 22562747 22563364 GSVIVG01034362001 17401340 17403115 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033876001 17078604 17080632 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01033876001 17078604 17080632 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01027609001 15075031 15083888 GO:0006303 double-strand break repair via nonhomologous end joining The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01027609001 15075031 15083888 GO:0006303 double-strand break repair via nonhomologous end joining The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate, driving the unwinding of the DNA helix. IEA GO:0004003 ATP-dependent DNA helicase activity GSVIVG01027609001 15075031 15083888 GO:0006303 double-strand break repair via nonhomologous end joining The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01007979001 7023614 7027080 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). IEA GO:0003755 peptidyl-prolyl cis-trans isomerase activity GSVIVG01007979001 7023614 7027080 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. IEA GO:0016853 isomerase activity GSVIVG01001420001 18948926 18949435 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01018453001 14861395 14863190 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01029337001 14593393 14610766 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029337001 14593393 14610766 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: ADP + phosphate + acetyl-CoA + oxaloacetate = ATP + citrate + CoA. IEA GO:0003878 ATP citrate synthase activity GSVIVG01029337001 14593393 14610766 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: ATP + succinate + CoA = ADP + succinyl-CoA + phosphate. IEA GO:0004775 succinate-CoA ligase (ADP-forming) activity GSVIVG01029337001 14593393 14610766 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01021975001 4826073 4828023 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01021975001 4826073 4828023 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01021975001 4826073 4828023 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01021975001 4826073 4828023 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01021975001 4826073 4828023 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015935 small ribosomal subunit The smaller of the two subunits of a ribosome. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01021975001 4826073 4828023 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01021975001 4826073 4828023 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01021975001 4826073 4828023 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01021975001 4826073 4828023 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01021975001 4826073 4828023 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01021975001 4826073 4828023 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015935 small ribosomal subunit The smaller of the two subunits of a ribosome. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01021975001 4826073 4828023 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01021975001 4826073 4828023 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ribosomal RNA. IEA GO:0019843 rRNA binding GSVIVG01021975001 4826073 4828023 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with ribosomal RNA. IEA GO:0019843 rRNA binding GSVIVG01021975001 4826073 4828023 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Interacting selectively and non-covalently with ribosomal RNA. IEA GO:0019843 rRNA binding GSVIVG01021975001 4826073 4828023 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Interacting selectively and non-covalently with ribosomal RNA. IEA GO:0019843 rRNA binding GSVIVG01021975001 4826073 4828023 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015935 small ribosomal subunit The smaller of the two subunits of a ribosome. IEA Interacting selectively and non-covalently with ribosomal RNA. IEA GO:0019843 rRNA binding GSVIVG01021975001 4826073 4828023 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA Interacting selectively and non-covalently with ribosomal RNA. IEA GO:0019843 rRNA binding GSVIVG01010103001 15497306 15497946 GSVIVG01032468001 27711219 27711311 GSVIVG01022962001 17522064 17534730 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with luteinizing hormone (also called lutropin) to initiate a change in cell activity. IEA GO:0004964 luteinizing hormone receptor activity GSVIVG01022962001 17522064 17534730 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01005747001 21784305 21788695 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01005747001 21784305 21788695 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01034947001 365486 371314 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01034947001 365486 371314 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01034947001 365486 371314 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01027144001 17448998 17463861 GSVIVG01014693001 8704992 8712705 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014693001 8704992 8712705 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014693001 8704992 8712705 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014693001 8704992 8712705 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01014693001 8704992 8712705 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01014693001 8704992 8712705 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014693001 8704992 8712705 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01030412001 5370351 5375232 GO:0032313 regulation of Rab GTPase activity Any process that modulates the activity of a GTPase of the Rab family. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Increases the rate of GTP hydrolysis by a GTPase of the Rab family. IEA GO:0005097 Rab GTPase activator activity GSVIVG01028324001 6157858 6160908 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01024130001 885397 885684 GSVIVG01023825001 3181821 3183254 GSVIVG01011062001 1881719 1887450 GO:0005788 endoplasmic reticulum lumen The volume enclosed by the membranes of the endoplasmic reticulum. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01029429001 23005201 23006644 GSVIVG01018745001 20251894 20253027 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01003337001 9152594 9161096 GSVIVG01016138001 19588969 19594664 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01001886001 6780285 6781023 GSVIVG01038099001 23489773 23496002 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GSVIVG01018503001 14231859 14241447 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01018503001 14231859 14241447 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01018503001 14231859 14241447 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01018503001 14231859 14241447 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01025190001 3560642 3561675 GSVIVG01029347001 14953743 14955539 GSVIVG01021495001 6150700 6185828 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003548001 14524923 14526703 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01003548001 14524923 14526703 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01033666001 18818927 18823152 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01033666001 18818927 18823152 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01033666001 18818927 18823152 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01033666001 18818927 18823152 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01019452001 785042 785798 GSVIVG01008935001 3577962 3582206 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01008935001 3577962 3582206 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008935001 3577962 3582206 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01008935001 3577962 3582206 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with molybdenum (Mo) ions. IEA GO:0030151 molybdenum ion binding GSVIVG01008935001 3577962 3582206 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01018589001 12718308 12719702 GSVIVG01009316001 7309172 7310247 GSVIVG01010637001 15726420 15727350 GSVIVG01030210001 10408287 10408421 GSVIVG01037223001 27762784 27764096 GSVIVG01008932001 3555522 3560233 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01006968001 29472045 29475999 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01006968001 29472045 29475999 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01006968001 29472045 29475999 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01006968001 29472045 29475999 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01032698001 1430017 1445333 GSVIVG01032076001 22957538 22960581 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01017565001 10606663 10608477 GO:0005759 mitochondrial matrix The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. IEA GSVIVG01015057001 762973 771322 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01015057001 762973 771322 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01015057001 762973 771322 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015057001 762973 771322 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01032603001 28767155 28769671 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01011710001 4894994 4897616 GSVIVG01031943001 5581839 5591761 GSVIVG01018596001 12536768 12549106 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Catalysis of the reaction: ATP + shikimate = ADP + shikimate 3-phosphate. IEA GO:0004765 shikimate kinase activity GSVIVG01018596001 12536768 12549106 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018596001 12536768 12549106 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a phosphate group (acceptor). IEA GO:0016776 phosphotransferase activity, phosphate group as acceptor GSVIVG01018596001 12536768 12549106 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Catalysis of the reaction: ATP + nucleoside monophosphate = ADP + nucleoside diphosphate. IEA GO:0019201 nucleotide kinase activity GSVIVG01018596001 12536768 12549106 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate. IEA GO:0019205 nucleobase, nucleoside, nucleotide kinase activity GSVIVG01000833001 2680633 2682676 GSVIVG01038723001 20587738 20590722 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01038723001 20587738 20590722 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01038723001 20587738 20590722 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01038723001 20587738 20590722 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027630001 14868350 14890351 GSVIVG01022340001 18672765 18681038 GO:0030328 prenylcysteine catabolic process The chemical reactions and pathways resulting in the breakdown of prenylcysteine, 3-methyl-2-buten-1-yl-cysteine, a derivative of the amino acid cysteine formed by the covalent addition of a prenyl residue. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022340001 18672765 18681038 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022340001 18672765 18681038 GO:0030328 prenylcysteine catabolic process The chemical reactions and pathways resulting in the breakdown of prenylcysteine, 3-methyl-2-buten-1-yl-cysteine, a derivative of the amino acid cysteine formed by the covalent addition of a prenyl residue. IEA Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces oxygen. IEA GO:0016670 oxidoreductase activity, acting on sulfur group of donors, oxygen as acceptor GSVIVG01022340001 18672765 18681038 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces oxygen. IEA GO:0016670 oxidoreductase activity, acting on sulfur group of donors, oxygen as acceptor GSVIVG01027638001 14785253 14791268 GSVIVG01023623001 8132098 8141749 GSVIVG01026545001 22005531 22034340 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026545001 22005531 22034340 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025142001 4013052 4013794 Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01025142001 4013052 4013794 Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01022631001 13772327 13858248 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01022631001 13772327 13858248 GO:0006270 DNA-dependent DNA replication initiation The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01022631001 13772327 13858248 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01022631001 13772327 13858248 GO:0015995 chlorophyll biosynthetic process The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01022631001 13772327 13858248 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01022631001 13772327 13858248 GO:0006270 DNA-dependent DNA replication initiation The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01022631001 13772327 13858248 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01022631001 13772327 13858248 GO:0015995 chlorophyll biosynthetic process The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01022631001 13772327 13858248 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022631001 13772327 13858248 GO:0006270 DNA-dependent DNA replication initiation The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022631001 13772327 13858248 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022631001 13772327 13858248 GO:0015995 chlorophyll biosynthetic process The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022631001 13772327 13858248 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + protoporphyrin IX + Mg2+ + H2O = ADP + phosphate + Mg-protoporphyrin IX + 2 H+. IEA GO:0016851 magnesium chelatase activity GSVIVG01022631001 13772327 13858248 GO:0006270 DNA-dependent DNA replication initiation The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + protoporphyrin IX + Mg2+ + H2O = ADP + phosphate + Mg-protoporphyrin IX + 2 H+. IEA GO:0016851 magnesium chelatase activity GSVIVG01022631001 13772327 13858248 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + protoporphyrin IX + Mg2+ + H2O = ADP + phosphate + Mg-protoporphyrin IX + 2 H+. IEA GO:0016851 magnesium chelatase activity GSVIVG01022631001 13772327 13858248 GO:0015995 chlorophyll biosynthetic process The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + protoporphyrin IX + Mg2+ + H2O = ADP + phosphate + Mg-protoporphyrin IX + 2 H+. IEA GO:0016851 magnesium chelatase activity GSVIVG01022631001 13772327 13858248 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01022631001 13772327 13858248 GO:0006270 DNA-dependent DNA replication initiation The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01022631001 13772327 13858248 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01022631001 13772327 13858248 GO:0015995 chlorophyll biosynthetic process The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01022631001 13772327 13858248 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01022631001 13772327 13858248 GO:0006270 DNA-dependent DNA replication initiation The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01022631001 13772327 13858248 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01022631001 13772327 13858248 GO:0015995 chlorophyll biosynthetic process The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01007755001 9403896 9557083 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01007755001 9403896 9557083 Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01031472001 18179364 18181369 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031472001 18179364 18181369 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031472001 18179364 18181369 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031472001 18179364 18181369 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031472001 18179364 18181369 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031472001 18179364 18181369 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031472001 18179364 18181369 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01031472001 18179364 18181369 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01031472001 18179364 18181369 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01031472001 18179364 18181369 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031472001 18179364 18181369 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031472001 18179364 18181369 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01029485001 22354165 22354489 GSVIVG01021189001 2441876 2445411 GSVIVG01019304001 1564475 1568511 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01019304001 1564475 1568511 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01019304001 1564475 1568511 GO:0051260 protein homooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01019304001 1564475 1568511 GO:0051260 protein homooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01012570001 3750204 3751638 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012570001 3750204 3751638 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01030056001 9294601 9304381 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030056001 9294601 9304381 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030056001 9294601 9304381 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01030056001 9294601 9304381 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01021366001 4527597 4542982 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01021366001 4527597 4542982 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01021366001 4527597 4542982 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021366001 4527597 4542982 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021366001 4527597 4542982 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01021366001 4527597 4542982 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01021366001 4527597 4542982 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01021366001 4527597 4542982 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01021366001 4527597 4542982 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01021366001 4527597 4542982 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01022287001 18228013 18230306 GSVIVG01017480001 9077998 9102859 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017480001 9077998 9102859 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017480001 9077998 9102859 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017480001 9077998 9102859 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024517001 9374011 9384644 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01038474001 9989270 10030836 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01038474001 9989270 10030836 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01032657001 1751857 1775361 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01032657001 1751857 1775361 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01032657001 1751857 1775361 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01032657001 1751857 1775361 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Combining with ecdysteroid hormone to initiate a change in cell activity. IEA GO:0004884 ecdysteroid hormone receptor activity GSVIVG01032657001 1751857 1775361 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene. IEA GO:0005496 steroid binding GSVIVG01032657001 1751857 1775361 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032657001 1751857 1775361 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032657001 1751857 1775361 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01024041001 1540153 1548972 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01024041001 1540153 1548972 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01024041001 1540153 1548972 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01001131001 22865693 22867173 GSVIVG01033083001 25599334 25604371 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01027798001 7860396 7886932 GSVIVG01036971001 9394207 9397960 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01036971001 9394207 9397960 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01036971001 9394207 9397960 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the formation of a 2,3-epoxide in squalene. IEA GO:0004506 squalene monooxygenase activity GSVIVG01036971001 9394207 9397960 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the formation of a 2,3-epoxide in squalene. IEA GO:0004506 squalene monooxygenase activity GSVIVG01036971001 9394207 9397960 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01036971001 9394207 9397960 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01036971001 9394207 9397960 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01036971001 9394207 9397960 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01036971001 9394207 9397960 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01036971001 9394207 9397960 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01002029001 32374568 32389660 GSVIVG01033996001 16021976 16030176 GO:0031167 rRNA methylation The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01033996001 16021976 16030176 GO:0032259 methylation The process by which a methyl group is covalently attached to a molecule. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01033996001 16021976 16030176 GO:0031167 rRNA methylation The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01033996001 16021976 16030176 GO:0032259 methylation The process by which a methyl group is covalently attached to a molecule. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01015715001 16254647 16267837 GSVIVG01029257001 17936593 17938168 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029257001 17936593 17938168 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01023014001 16902043 16904750 GSVIVG01007454001 32045079 32045692 GSVIVG01008609001 433721 440709 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008609001 433721 440709 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01027151001 17405674 17406259 GSVIVG01032760001 960837 961597 GSVIVG01034660001 12945922 12949814 GSVIVG01032917001 24101246 24107321 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000622001 13989275 14016964 GO:0006075 1,3-beta-glucan biosynthetic process The chemical reactions and pathways resulting in the formation of beta-1,3 glucans, compounds composed of glucose residues linked by 1,3-beta-D-glucosidic bonds. IEA GO:0000148 1,3-beta-glucan synthase complex A protein complex that catalyzes the transfer of a glucose moiety from UDP-glucose to a 1,3-beta-D-glucan chain. IEA Catalysis of the reaction: UDP-glucose + 1,3-beta-D-glucosyl(n) = UDP + 1,3-beta-D-glucosyl(n+1). IEA GO:0003843 1,3-beta-glucan synthase activity GSVIVG01000622001 13989275 14016964 GO:0006075 1,3-beta-glucan biosynthetic process The chemical reactions and pathways resulting in the formation of beta-1,3 glucans, compounds composed of glucose residues linked by 1,3-beta-D-glucosidic bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: UDP-glucose + 1,3-beta-D-glucosyl(n) = UDP + 1,3-beta-D-glucosyl(n+1). IEA GO:0003843 1,3-beta-glucan synthase activity GSVIVG01005287001 550877 551982 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01005287001 550877 551982 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01005287001 550877 551982 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01005287001 550877 551982 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01005287001 550877 551982 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01005287001 550877 551982 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014309001 2535019 2537063 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01014309001 2535019 2537063 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01014309001 2535019 2537063 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01014309001 2535019 2537063 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01032423001 27247154 27261360 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01032423001 27247154 27261360 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01027110001 17800046 17804928 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01001248001 4505261 4505934 GSVIVG01035646001 2957072 2958231 GSVIVG01031555001 17213987 17224755 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031555001 17213987 17224755 GO:0015995 chlorophyll biosynthetic process The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031555001 17213987 17224755 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA Catalysis of the reaction: ATP + protoporphyrin IX + Mg2+ + H2O = ADP + phosphate + Mg-protoporphyrin IX + 2 H+. IEA GO:0016851 magnesium chelatase activity GSVIVG01031555001 17213987 17224755 GO:0015995 chlorophyll biosynthetic process The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors. IEA Catalysis of the reaction: ATP + protoporphyrin IX + Mg2+ + H2O = ADP + phosphate + Mg-protoporphyrin IX + 2 H+. IEA GO:0016851 magnesium chelatase activity GSVIVG01014167001 1020158 1034257 GO:0006541 glutamine metabolic process The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01014167001 1020158 1034257 GO:0006541 glutamine metabolic process The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid. IEA Catalysis of the removal of terminal peptide residues that are substituted, cyclized or linked by isopeptide bonds (peptide linkages other than those of alpha-carboxyl to alpha-amino groups). IEA GO:0008242 omega peptidase activity GSVIVG01014167001 1020158 1034257 GO:0006541 glutamine metabolic process The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01028186001 4481602 4485836 GO:0006820 anion transport The directed movement of anions, atoms or small molecules with a net negative charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA IEA GO:0005452 inorganic anion exchanger activity GSVIVG01028186001 4481602 4485836 GO:0006820 anion transport The directed movement of anions, atoms or small molecules with a net negative charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA IEA GO:0005452 inorganic anion exchanger activity GSVIVG01028186001 4481602 4485836 GO:0006820 anion transport The directed movement of anions, atoms or small molecules with a net negative charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA IEA GO:0015380 anion exchanger activity GSVIVG01028186001 4481602 4485836 GO:0006820 anion transport The directed movement of anions, atoms or small molecules with a net negative charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA IEA GO:0015380 anion exchanger activity GSVIVG01035923001 5932038 5936741 GSVIVG01031410001 18952516 18968528 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01031410001 18952516 18968528 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01031410001 18952516 18968528 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01031410001 18952516 18968528 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031410001 18952516 18968528 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031410001 18952516 18968528 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01031410001 18952516 18968528 Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. IEA GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GSVIVG01031210001 1158475 1164483 GSVIVG01024647001 8070873 8071976 GSVIVG01010685001 11724139 11724986 GSVIVG01009381001 7895438 7897711 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01015220001 1906262 1907602 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01029755001 14218206 14219304 GSVIVG01033929001 16632191 16634520 GSVIVG01015729001 16533646 16536550 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01010071001 14794023 14795637 GSVIVG01030035001 9023065 9024961 GSVIVG01015020001 498435 509489 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01019922001 4488150 4493569 GSVIVG01001692001 14365661 14379400 GO:0000105 histidine biosynthetic process The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. IEA Catalysis of the reaction: L-histidinol + NAD+ = L-histidine + NADH + H+. IEA GO:0004399 histidinol dehydrogenase activity GSVIVG01001692001 14365661 14379400 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: L-histidinol + NAD+ = L-histidine + NADH + H+. IEA GO:0004399 histidinol dehydrogenase activity GSVIVG01001692001 14365661 14379400 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: L-histidinol + NAD+ = L-histidine + NADH + H+. IEA GO:0004399 histidinol dehydrogenase activity GSVIVG01001692001 14365661 14379400 GO:0000105 histidine biosynthetic process The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01001692001 14365661 14379400 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01001692001 14365661 14379400 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01001692001 14365661 14379400 GO:0000105 histidine biosynthetic process The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001692001 14365661 14379400 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001692001 14365661 14379400 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001692001 14365661 14379400 GO:0000105 histidine biosynthetic process The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01001692001 14365661 14379400 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01001692001 14365661 14379400 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01036969001 9408764 9412394 GSVIVG01036127001 20380321 20384264 GSVIVG01032508001 27978844 27989286 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01032508001 27978844 27989286 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01032508001 27978844 27989286 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with single-stranded DNA. IEA GO:0003697 single-stranded DNA binding GSVIVG01032508001 27978844 27989286 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with single-stranded DNA. IEA GO:0003697 single-stranded DNA binding GSVIVG01032508001 27978844 27989286 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032508001 27978844 27989286 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032508001 27978844 27989286 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids. IEA GO:0004518 nuclease activity GSVIVG01032508001 27978844 27989286 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids. IEA GO:0004518 nuclease activity GSVIVG01032508001 27978844 27989286 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. IEA GO:0004519 endonuclease activity GSVIVG01032508001 27978844 27989286 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. IEA GO:0004519 endonuclease activity GSVIVG01012263001 12630040 12638121 GSVIVG01019897001 4329210 4331242 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01025811001 11598470 11608650 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01025811001 11598470 11608650 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01025811001 11598470 11608650 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01000062001 3173908 3174962 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with manganese (Mn) ions. IEA GO:0030145 manganese ion binding GSVIVG01000062001 3173908 3174962 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Functions in the storage of nutritious substrates. IEA GO:0045735 nutrient reservoir activity GSVIVG01032046001 23211497 23240120 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024301001 672314 674501 GSVIVG01033498001 20234672 20241344 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01033498001 20234672 20241344 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and primer. IEA GO:0003887 DNA-directed DNA polymerase activity GSVIVG01019024001 17615878 17627150 GO:0018279 protein amino acid N-linked glycosylation via asparagine The posttranslational glycosylation of protein via the N4 atom of peptidyl-asparagine forming N4-glycosyl-L-asparagine; the most common form is N-acetylglucosaminyl asparagine; N-acetylgalactosaminyl asparagine also occurs; this modification typically occurs in extracellular peptides with an N-X-(ST) motif. Partial modification has been observed to occur with cysteine, rather than serine or threonine, in the third position; secondary structure features are important, and proline in the second or fourth positions inhibits modification. IEA GO:0005789 endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum. IEA Catalysis of the reaction: dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by glycosylamine linkage to protein L-asparagine. IEA GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity GSVIVG01011810001 3939296 3943923 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01011810001 3939296 3943923 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01011810001 3939296 3943923 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the reaction: D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate. IEA GO:0004332 fructose-bisphosphate aldolase activity GSVIVG01011810001 3939296 3943923 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate. IEA GO:0004332 fructose-bisphosphate aldolase activity GSVIVG01025185001 3602472 3607341 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01025185001 3602472 3607341 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01025185001 3602472 3607341 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01025185001 3602472 3607341 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035053001 1203948 1224887 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01035053001 1203948 1224887 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01027072001 18163014 18170175 GO:0042254 ribosome biogenesis The process of the formation of the constituents of the ribosome subunits, their assembly, and their transport to the sites of protein synthesis. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01036371001 4309093 4314526 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01036371001 4309093 4314526 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01035671001 3182895 3185794 GSVIVG01006677001 27400009 27401031 GSVIVG01019115001 16612723 16613548 GSVIVG01037079001 7999219 8021041 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004185 serine-type carboxypeptidase activity GSVIVG01037079001 7999219 8021041 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01037251001 16905816 16907402 Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01037251001 16905816 16907402 Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01037251001 16905816 16907402 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01037251001 16905816 16907402 Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01001497001 5162873 5163316 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01001497001 5162873 5163316 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026639001 20833741 20841170 GSVIVG01030182001 10751372 10767781 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01030182001 10751372 10767781 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01018916001 18678517 18680377 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01017138001 4516346 4516732 GSVIVG01031686001 20191284 20210800 GSVIVG01004862001 16173320 16174896 GSVIVG01035555001 2258248 2263610 GSVIVG01011678001 5295143 5301096 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01011767001 4353649 4358006 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01011767001 4353649 4358006 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01037064001 8232628 8239401 GSVIVG01033015001 25072966 25074549 GSVIVG01023137001 22174982 22176298 GO:0051260 protein homooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01012038001 1932548 1958549 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01012038001 1932548 1958549 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012038001 1932548 1958549 Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01012038001 1932548 1958549 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01009259001 6751783 6760147 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01025466001 593134 594091 GSVIVG01015824001 17918851 17928072 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015824001 17918851 17928072 Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. IEA GO:0008483 transaminase activity GSVIVG01015824001 17918851 17928072 Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01036762001 22886899 22896623 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01036762001 22886899 22896623 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01036762001 22886899 22896623 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01036762001 22886899 22896623 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01036762001 22886899 22896623 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01036762001 22886899 22896623 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01036762001 22886899 22896623 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01036762001 22886899 22896623 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01036762001 22886899 22896623 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01036762001 22886899 22896623 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01036762001 22886899 22896623 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01036762001 22886899 22896623 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01018014001 5481021 5492341 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01018014001 5481021 5492341 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01018014001 5481021 5492341 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030255001 9827453 9827677 GSVIVG01001765001 6228051 6228768 GSVIVG01014708001 8878190 8883497 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01035765001 4123087 4132649 GSVIVG01012094001 1537354 1545134 GSVIVG01002252001 33706921 33707610 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017657001 2411938 2413331 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01025467001 585656 587574 GSVIVG01015422001 3521464 3524010 GSVIVG01014576001 5329128 5331056 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01026915001 19418350 19422948 GSVIVG01005576001 40650128 40651612 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01005576001 40650128 40651612 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01027484001 16422227 16423660 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GSVIVG01027484001 16422227 16423660 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GSVIVG01001052001 7097152 7101890 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01001052001 7097152 7101890 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01001052001 7097152 7101890 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01001052001 7097152 7101890 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01001052001 7097152 7101890 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01001052001 7097152 7101890 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01001052001 7097152 7101890 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001052001 7097152 7101890 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001052001 7097152 7101890 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001052001 7097152 7101890 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001052001 7097152 7101890 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001052001 7097152 7101890 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001052001 7097152 7101890 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001052001 7097152 7101890 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001052001 7097152 7101890 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001052001 7097152 7101890 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001052001 7097152 7101890 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001052001 7097152 7101890 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001052001 7097152 7101890 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01001052001 7097152 7101890 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01001052001 7097152 7101890 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01001052001 7097152 7101890 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01001052001 7097152 7101890 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01001052001 7097152 7101890 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01001052001 7097152 7101890 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01001052001 7097152 7101890 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01001052001 7097152 7101890 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01001052001 7097152 7101890 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01001052001 7097152 7101890 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01001052001 7097152 7101890 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01001052001 7097152 7101890 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01001052001 7097152 7101890 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01001052001 7097152 7101890 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01001052001 7097152 7101890 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01001052001 7097152 7101890 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01001052001 7097152 7101890 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01001052001 7097152 7101890 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01001052001 7097152 7101890 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01001052001 7097152 7101890 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01001052001 7097152 7101890 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01001052001 7097152 7101890 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01001052001 7097152 7101890 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01038513001 10825483 10834289 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GSVIVG01001316001 5255210 5256154 GSVIVG01018444001 15047131 15049427 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01018444001 15047131 15049427 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. IEA GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GSVIVG01018444001 15047131 15049427 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species. IEA GO:0031418 L-ascorbic acid binding GSVIVG01024520001 9327648 9331555 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01005290001 20224185 20224645 GSVIVG01004414001 38474156 38476221 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01004414001 38474156 38476221 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01004414001 38474156 38476221 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01004414001 38474156 38476221 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01004414001 38474156 38476221 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01004414001 38474156 38476221 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01004414001 38474156 38476221 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01004414001 38474156 38476221 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01004414001 38474156 38476221 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01004414001 38474156 38476221 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01004414001 38474156 38476221 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01004414001 38474156 38476221 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01004414001 38474156 38476221 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01004414001 38474156 38476221 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01004414001 38474156 38476221 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01004414001 38474156 38476221 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01004414001 38474156 38476221 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01004414001 38474156 38476221 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01012261001 10731 27033 GSVIVG01038221001 24454635 24457984 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01038221001 24454635 24457984 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01038221001 24454635 24457984 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01038221001 24454635 24457984 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01038221001 24454635 24457984 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01038221001 24454635 24457984 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01038221001 24454635 24457984 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01038221001 24454635 24457984 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01017319001 6691280 6698285 GSVIVG01019603001 1877335 1878365 GSVIVG01018322001 11096672 11122882 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01018322001 11096672 11122882 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01018322001 11096672 11122882 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01018322001 11096672 11122882 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01005915001 22613258 22614886 GO:0019953 sexual reproduction The regular alternation, in the life cycle of haplontic, diplontic and diplohaplontic organisms, of meiosis and fertilization which provides for the production offspring. In diplontic organisms there is a life cycle in which the products of meiosis behave directly as gametes, fusing to form a zygote from which the diploid, or sexually reproductive polyploid, adult organism will develop. In diplohaplontic organisms a haploid phase (gametophyte) exists in the life cycle between meiosis and fertilization (e.g. higher plants, many algae and Fungi); the products of meiosis are spores that develop as haploid individuals from which haploid gametes develop to form a diploid zygote; diplohaplontic organisms show an alternation of haploid and diploid generations. In haplontic organisms meiosis occurs in the zygote, giving rise to four haploid cells (e.g. many algae and protozoa), only the zygote is diploid and this may form a resistant spore, tiding organisms over hard times. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA GSVIVG01038664001 21124895 21126512 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01038664001 21124895 21126512 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01038664001 21124895 21126512 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008237 metallopeptidase activity GSVIVG01038664001 21124895 21126512 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008237 metallopeptidase activity GSVIVG01038664001 21124895 21126512 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01038664001 21124895 21126512 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01038664001 21124895 21126512 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01038664001 21124895 21126512 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01024236001 105683 107912 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01024236001 105683 107912 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01024236001 105683 107912 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01024236001 105683 107912 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013225001 6558535 6560391 GSVIVG01018253001 12508492 12509830 GSVIVG01033123001 7943541 7951247 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0031461 cullin-RING ubiquitin ligase complex Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01033123001 7943541 7951247 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0031461 cullin-RING ubiquitin ligase complex Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01033123001 7943541 7951247 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0031461 cullin-RING ubiquitin ligase complex Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01033123001 7943541 7951247 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0031461 cullin-RING ubiquitin ligase complex Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01033123001 7943541 7951247 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0031461 cullin-RING ubiquitin ligase complex Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01033123001 7943541 7951247 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0031461 cullin-RING ubiquitin ligase complex Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01033123001 7943541 7951247 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0031461 cullin-RING ubiquitin ligase complex Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity. IEA Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins. IEA GO:0031625 ubiquitin protein ligase binding GSVIVG01033123001 7943541 7951247 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0031461 cullin-RING ubiquitin ligase complex Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity. IEA Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins. IEA GO:0031625 ubiquitin protein ligase binding GSVIVG01033123001 7943541 7951247 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0031461 cullin-RING ubiquitin ligase complex Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity. IEA Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins. IEA GO:0031625 ubiquitin protein ligase binding GSVIVG01010592001 16227283 16227553 GSVIVG01023855001 2937535 2942467 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023855001 2937535 2942467 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023855001 2937535 2942467 GO:0006424 glutamyl-tRNA aminoacylation The process of coupling glutamate to glutamyl-tRNA, catalyzed by glutamyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'- adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023855001 2937535 2942467 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01023855001 2937535 2942467 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01023855001 2937535 2942467 GO:0006424 glutamyl-tRNA aminoacylation The process of coupling glutamate to glutamyl-tRNA, catalyzed by glutamyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'- adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01023855001 2937535 2942467 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu). IEA GO:0004818 glutamate-tRNA ligase activity GSVIVG01023855001 2937535 2942467 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu). IEA GO:0004818 glutamate-tRNA ligase activity GSVIVG01023855001 2937535 2942467 GO:0006424 glutamyl-tRNA aminoacylation The process of coupling glutamate to glutamyl-tRNA, catalyzed by glutamyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'- adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu). IEA GO:0004818 glutamate-tRNA ligase activity GSVIVG01023855001 2937535 2942467 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023855001 2937535 2942467 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023855001 2937535 2942467 GO:0006424 glutamyl-tRNA aminoacylation The process of coupling glutamate to glutamyl-tRNA, catalyzed by glutamyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'- adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023855001 2937535 2942467 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01023855001 2937535 2942467 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01023855001 2937535 2942467 GO:0006424 glutamyl-tRNA aminoacylation The process of coupling glutamate to glutamyl-tRNA, catalyzed by glutamyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'- adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01034123001 15008245 15011519 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038649001 21215731 21223306 GSVIVG01034421001 16540107 16540545 GSVIVG01021471001 5908070 5913091 GSVIVG01023078001 15719959 15725068 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01028041001 3365104 3368302 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Stops, prevents or reduces the activity of an enzyme. IEA GO:0004857 enzyme inhibitor activity GSVIVG01028041001 3365104 3368302 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the reaction: pectin + n H2O = n methanol + pectate. IEA GO:0030599 pectinesterase activity GSVIVG01019793001 3335864 3346096 GSVIVG01035335001 572418 580248 GSVIVG01011777001 4242907 4245730 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01001991001 6120152 6129270 GSVIVG01023907001 2536206 2541814 GSVIVG01004475001 38785400 38788140 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01011038001 2058311 2059608 GSVIVG01034634001 13621749 13659063 GO:0006144 purine base metabolic process The chemical reactions and pathways involving purine bases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine. IEA Catalysis of the reaction: urate + O2 + H2O = 5-hydroxyisourate + H2O2. IEA GO:0004846 urate oxidase activity GSVIVG01034634001 13621749 13659063 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: urate + O2 + H2O = 5-hydroxyisourate + H2O2. IEA GO:0004846 urate oxidase activity GSVIVG01034634001 13621749 13659063 GO:0006144 purine base metabolic process The chemical reactions and pathways involving purine bases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01034634001 13621749 13659063 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01017607001 1962650 1964733 GSVIVG01017571001 10752760 10753553 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01017571001 10752760 10753553 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01006524001 42854214 42855240 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01006524001 42854214 42855240 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034392001 16910115 16917914 GSVIVG01000123001 15444488 15450475 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01000123001 15444488 15450475 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01000123001 15444488 15450475 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01000123001 15444488 15450475 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000123001 15444488 15450475 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000123001 15444488 15450475 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000123001 15444488 15450475 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of calcium (Ca) ions from one side of a membrane to the other. IEA GO:0015085 calcium ion transmembrane transporter activity GSVIVG01000123001 15444488 15450475 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of calcium (Ca) ions from one side of a membrane to the other. IEA GO:0015085 calcium ion transmembrane transporter activity GSVIVG01000123001 15444488 15450475 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of calcium (Ca) ions from one side of a membrane to the other. IEA GO:0015085 calcium ion transmembrane transporter activity GSVIVG01000123001 15444488 15450475 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01000123001 15444488 15450475 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01000123001 15444488 15450475 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01000123001 15444488 15450475 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01000123001 15444488 15450475 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01000123001 15444488 15450475 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01023130001 22270683 22280802 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0009360 DNA polymerase III complex A DNA polymerase complex that contains two complexes of the catalytic alpha, beta, delta and epsilon polymerase/exonuclease subunits, plus the DnaX complex, a heptamer that includes the tau and gamma products of the dnaX gene and confers structural asymmetry that allows the polymerase to replicate both leading and lagging strands. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023130001 22270683 22280802 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0009360 DNA polymerase III complex A DNA polymerase complex that contains two complexes of the catalytic alpha, beta, delta and epsilon polymerase/exonuclease subunits, plus the DnaX complex, a heptamer that includes the tau and gamma products of the dnaX gene and confers structural asymmetry that allows the polymerase to replicate both leading and lagging strands. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01023130001 22270683 22280802 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0009360 DNA polymerase III complex A DNA polymerase complex that contains two complexes of the catalytic alpha, beta, delta and epsilon polymerase/exonuclease subunits, plus the DnaX complex, a heptamer that includes the tau and gamma products of the dnaX gene and confers structural asymmetry that allows the polymerase to replicate both leading and lagging strands. IEA Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and primer. IEA GO:0003887 DNA-directed DNA polymerase activity GSVIVG01023130001 22270683 22280802 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0009360 DNA polymerase III complex A DNA polymerase complex that contains two complexes of the catalytic alpha, beta, delta and epsilon polymerase/exonuclease subunits, plus the DnaX complex, a heptamer that includes the tau and gamma products of the dnaX gene and confers structural asymmetry that allows the polymerase to replicate both leading and lagging strands. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023130001 22270683 22280802 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0009360 DNA polymerase III complex A DNA polymerase complex that contains two complexes of the catalytic alpha, beta, delta and epsilon polymerase/exonuclease subunits, plus the DnaX complex, a heptamer that includes the tau and gamma products of the dnaX gene and confers structural asymmetry that allows the polymerase to replicate both leading and lagging strands. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01020190001 9257531 9285762 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01034623001 14117602 14119399 GSVIVG01035723001 3669069 3680305 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01021238001 2867315 2877937 GSVIVG01038208001 24365063 24368368 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01038208001 24365063 24368368 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01038208001 24365063 24368368 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01038208001 24365063 24368368 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01038208001 24365063 24368368 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01038208001 24365063 24368368 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01038208001 24365063 24368368 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01038208001 24365063 24368368 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01015946001 16021508 16023034 GSVIVG01008551001 938854 939343 GO:0006605 protein targeting The process of targeting specific proteins to particular membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01008551001 938854 939343 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01008551001 938854 939343 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01008351001 3021897 3034010 GSVIVG01018098001 6530595 6532523 GSVIVG01023000001 17114212 17115211 Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01023000001 17114212 17115211 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01000098001 3517524 3522383 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with manganese (Mn) ions. IEA GO:0030145 manganese ion binding GSVIVG01000098001 3517524 3522383 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Functions in the storage of nutritious substrates. IEA GO:0045735 nutrient reservoir activity GSVIVG01000098001 3517524 3522383 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01028563001 9895504 9900254 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with luteinizing hormone (also called lutropin) to initiate a change in cell activity. IEA GO:0004964 luteinizing hormone receptor activity GSVIVG01001693001 14379717 14382149 GSVIVG01014484001 4321541 4325220 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014484001 4321541 4325220 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014484001 4321541 4325220 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014484001 4321541 4325220 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014484001 4321541 4325220 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014484001 4321541 4325220 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014484001 4321541 4325220 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014484001 4321541 4325220 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019414001 470207 475234 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019414001 470207 475234 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). IEA GO:0016769 transferase activity, transferring nitrogenous groups GSVIVG01019414001 470207 475234 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + methylthioadenosine. IEA GO:0016847 1-aminocyclopropane-1-carboxylate synthase activity GSVIVG01019414001 470207 475234 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01001767001 6250745 6251770 GSVIVG01031965001 5779677 5782836 GSVIVG01006121001 41812900 41815383 GSVIVG01025842001 11313101 11320356 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01011374001 29102130 29132698 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01011374001 29102130 29132698 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01011374001 29102130 29132698 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01011374001 29102130 29132698 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01011374001 29102130 29132698 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019763001 3130323 3137368 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01009594001 9728435 9731085 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01009594001 9728435 9731085 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01009594001 9728435 9731085 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01009594001 9728435 9731085 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01022709001 15383034 15383646 GSVIVG01018050001 5807952 5812140 GSVIVG01001986001 6077331 6085291 GSVIVG01037582001 10638700 10658778 GSVIVG01029339001 14646146 14654828 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a oligosaccharyl group to an acceptor molecule, typically another carbohydrate or a lipid. IEA GO:0004576 oligosaccharyl transferase activity GSVIVG01029339001 14646146 14654828 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01029134001 19291289 19291795 GSVIVG01009338001 7537371 7539440 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01009338001 7537371 7539440 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01010469001 20835862 20852573 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01010469001 20835862 20852573 Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. IEA GO:0008171 O-methyltransferase activity GSVIVG01010469001 20835862 20852573 Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01003823001 20445939 20454938 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: 3-alpha(S)-strictosidine = tryptamine + secologanin. IEA GO:0016844 strictosidine synthase activity GSVIVG01026905001 19519102 19519350 GSVIVG01019835001 3754955 3774888 GSVIVG01032377001 26808121 26812863 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01027327001 16542825 16562965 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029498001 22243829 22244482 GSVIVG01022846001 18791932 18830471 GSVIVG01008018001 6639930 6640340 GSVIVG01014255001 2050404 2057179 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01014255001 2050404 2057179 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end. IEA GO:0004527 exonuclease activity GSVIVG01012617001 72191 76482 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01012617001 72191 76482 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01012617001 72191 76482 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01012617001 72191 76482 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036447001 22050931 22055841 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01036447001 22050931 22055841 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01009068001 4674346 4678256 Increases the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule. IEA GO:0019211 phosphatase activator activity GSVIVG01019227001 3066804 3067106 GSVIVG01005145001 18529304 18530034 GSVIVG01028712001 19516022 19518208 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01029827001 179896 208841 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01020504001 18279468 18280235 GSVIVG01037727001 7288188 7292433 GSVIVG01035373001 855695 856257 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01035373001 855695 856257 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035373001 855695 856257 Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01034007001 15947003 15947414 GSVIVG01024640001 8137169 8138132 GSVIVG01018566001 13271802 13279086 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018566001 13271802 13279086 GO:0008299 isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018566001 13271802 13279086 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA. IEA GO:0004421 hydroxymethylglutaryl-CoA synthase activity GSVIVG01018566001 13271802 13279086 GO:0008299 isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. IEA Catalysis of the reaction: acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA. IEA GO:0004421 hydroxymethylglutaryl-CoA synthase activity GSVIVG01021361001 4438285 4439990 GSVIVG01016523001 3150553 3152835 GSVIVG01012115001 1315728 1316069 GSVIVG01009317001 7322872 7323330 GSVIVG01028589001 10292022 10292150 GSVIVG01026204001 14036531 14036770 GSVIVG01027296001 16984989 16988124 GSVIVG01018032001 5705511 5709264 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01018032001 5705511 5709264 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01025906001 27344311 27347675 GSVIVG01030385001 5128944 5132398 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031737001 3930217 3943910 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031737001 3930217 3943910 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01031737001 3930217 3943910 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01032890001 23824203 23825846 GSVIVG01024915001 6075996 6080151 GSVIVG01009676001 10363407 10370119 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01009676001 10363407 10370119 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01009676001 10363407 10370119 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01009676001 10363407 10370119 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01036342001 3961864 3963611 GSVIVG01008341001 3106995 3109413 GSVIVG01030043001 9084490 9086822 GO:0009416 response to light stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01030043001 9084490 9086822 GO:0009416 response to light stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01011579001 6289243 6290820 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01011579001 6289243 6290820 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: D-galacturonate + NAD+ + H2O = D-galactarate + NADH. IEA GO:0050388 uronate dehydrogenase activity GSVIVG01003159001 6101674 6106138 GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA GSVIVG01031028001 21128259 21130563 GSVIVG01027832001 8304072 8304834 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01027832001 8304072 8304834 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01027832001 8304072 8304834 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01027832001 8304072 8304834 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001670001 14122252 14123294 GSVIVG01036422001 4932804 4934036 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01036422001 4932804 4934036 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01019185001 3844378 3844560 GSVIVG01004795001 125073 140057 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin. IEA GO:0004221 ubiquitin thiolesterase activity GSVIVG01021068001 14171952 14187569 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021068001 14171952 14187569 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01021068001 14171952 14187569 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01010097001 15308919 15323250 GSVIVG01007992001 6845879 6853538 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01007992001 6845879 6853538 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01031766001 4216320 4236204 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031766001 4216320 4236204 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01031766001 4216320 4236204 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008237 metallopeptidase activity GSVIVG01031766001 4216320 4236204 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01031766001 4216320 4236204 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01029780001 14581006 14584175 GSVIVG01027899001 9170578 9176581 GSVIVG01020165001 9518210 9519608 GSVIVG01014400001 3377437 3381785 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01014400001 3377437 3381785 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01014400001 3377437 3381785 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01017981001 5264179 5264916 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01017981001 5264179 5264916 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01017981001 5264179 5264916 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01017981001 5264179 5264916 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01017981001 5264179 5264916 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051537 2 iron, 2 sulfur cluster binding GSVIVG01032169001 21855028 21870589 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032169001 21855028 21870589 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032169001 21855028 21870589 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032169001 21855028 21870589 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033621001 19169513 19217398 GO:0006537 glutamate biosynthetic process The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033621001 19169513 19217398 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033621001 19169513 19217398 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033621001 19169513 19217398 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033621001 19169513 19217398 GO:0006537 glutamate biosynthetic process The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid. IEA Catalysis of the formation of L-glutamine and 2-oxoglutarate from L-glutamate, using NADH, NADPH or ferredoxin as hydrogen acceptors. IEA GO:0015930 glutamate synthase activity GSVIVG01033621001 19169513 19217398 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA Catalysis of the formation of L-glutamine and 2-oxoglutarate from L-glutamate, using NADH, NADPH or ferredoxin as hydrogen acceptors. IEA GO:0015930 glutamate synthase activity GSVIVG01033621001 19169513 19217398 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the formation of L-glutamine and 2-oxoglutarate from L-glutamate, using NADH, NADPH or ferredoxin as hydrogen acceptors. IEA GO:0015930 glutamate synthase activity GSVIVG01033621001 19169513 19217398 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the formation of L-glutamine and 2-oxoglutarate from L-glutamate, using NADH, NADPH or ferredoxin as hydrogen acceptors. IEA GO:0015930 glutamate synthase activity GSVIVG01033621001 19169513 19217398 GO:0006537 glutamate biosynthetic process The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid. IEA Catalysis of the reaction: 2 L-glutamate + 2 oxidized ferredoxin = L-glutamine + 2-oxoglutarate + 2 reduced ferredoxin + 2 H+. IEA GO:0016041 glutamate synthase (ferredoxin) activity GSVIVG01033621001 19169513 19217398 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA Catalysis of the reaction: 2 L-glutamate + 2 oxidized ferredoxin = L-glutamine + 2-oxoglutarate + 2 reduced ferredoxin + 2 H+. IEA GO:0016041 glutamate synthase (ferredoxin) activity GSVIVG01033621001 19169513 19217398 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2 L-glutamate + 2 oxidized ferredoxin = L-glutamine + 2-oxoglutarate + 2 reduced ferredoxin + 2 H+. IEA GO:0016041 glutamate synthase (ferredoxin) activity GSVIVG01033621001 19169513 19217398 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2 L-glutamate + 2 oxidized ferredoxin = L-glutamine + 2-oxoglutarate + 2 reduced ferredoxin + 2 H+. IEA GO:0016041 glutamate synthase (ferredoxin) activity GSVIVG01033621001 19169513 19217398 GO:0006537 glutamate biosynthetic process The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033621001 19169513 19217398 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033621001 19169513 19217398 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033621001 19169513 19217398 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01032167001 21878524 21878658 GSVIVG01037609001 6224946 6231062 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028945001 17185801 17186091 GSVIVG01000118001 15400830 15402370 GSVIVG01033609001 19342861 19351977 GSVIVG01010716001 12422926 12424354 GSVIVG01033665001 18825174 18828689 GSVIVG01032092001 22791693 22797039 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells. IEA GO:0015232 heme transporter activity GSVIVG01032092001 22791693 22797039 GO:0015886 heme transport The directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells. IEA GO:0015232 heme transporter activity GSVIVG01032092001 22791693 22797039 GO:0017004 cytochrome complex assembly The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells. IEA GO:0015232 heme transporter activity GSVIVG01032092001 22791693 22797039 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells. IEA GO:0015232 heme transporter activity GSVIVG01032092001 22791693 22797039 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01032092001 22791693 22797039 GO:0015886 heme transport The directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01032092001 22791693 22797039 GO:0017004 cytochrome complex assembly The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01032092001 22791693 22797039 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01032092001 22791693 22797039 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01032092001 22791693 22797039 GO:0015886 heme transport The directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01032092001 22791693 22797039 GO:0017004 cytochrome complex assembly The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01032092001 22791693 22797039 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01026057001 25182870 25199639 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01026057001 25182870 25199639 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01024249001 181447 188133 GSVIVG01004286001 37960840 37961490 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01004286001 37960840 37961490 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01027801001 7922304 7924729 GSVIVG01029198001 18635069 18638538 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01029198001 18635069 18638538 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01029198001 18635069 18638538 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01029198001 18635069 18638538 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01029198001 18635069 18638538 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01029198001 18635069 18638538 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01024768001 7114678 7116574 GO:0016481 negative regulation of transcription Any cellular process that stops, prevents or reduces the frequency, rate or extent of transcription. IEA Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0010181 FMN binding GSVIVG01024768001 7114678 7116574 GO:0016481 negative regulation of transcription Any cellular process that stops, prevents or reduces the frequency, rate or extent of transcription. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01036044001 7769837 7809190 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01036044001 7769837 7809190 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01036044001 7769837 7809190 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01036044001 7769837 7809190 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01036044001 7769837 7809190 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01036044001 7769837 7809190 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01022984001 17317266 17319554 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01022984001 17317266 17319554 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01022984001 17317266 17319554 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01022984001 17317266 17319554 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01022984001 17317266 17319554 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022984001 17317266 17319554 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022984001 17317266 17319554 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022984001 17317266 17319554 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001935001 14987188 14997385 GSVIVG01035034001 1058345 1062983 GSVIVG01001254001 4782154 4783888 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001254001 4782154 4783888 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001254001 4782154 4783888 Interacting selectively and non-covalently with biotin (cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid), the (+) enantiomer of which is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions. IEA GO:0009374 biotin binding GSVIVG01001254001 4782154 4783888 Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01000415001 7698253 7706286 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01006450001 26087354 26089005 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01002378001 34480812 34482204 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01002378001 34480812 34482204 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01002378001 34480812 34482204 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01002378001 34480812 34482204 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01014289001 2356592 2358344 GSVIVG01023922001 2462648 2464101 GSVIVG01019984001 11986695 11993881 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01019984001 11986695 11993881 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01003866001 5453 8979 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01018294001 11639731 11650780 GSVIVG01038452001 12640033 12662977 GSVIVG01022193001 17331292 17334987 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01022193001 17331292 17334987 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01022193001 17331292 17334987 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01022193001 17331292 17334987 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01022193001 17331292 17334987 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01022193001 17331292 17334987 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01022193001 17331292 17334987 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01022193001 17331292 17334987 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01022193001 17331292 17334987 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01022193001 17331292 17334987 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01022193001 17331292 17334987 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01022193001 17331292 17334987 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01022193001 17331292 17334987 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022193001 17331292 17334987 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022193001 17331292 17334987 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008707001 1351279 1357082 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01008707001 1351279 1357082 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01012817001 5689618 5689887 GSVIVG01024626001 8269212 8280258 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01024626001 8269212 8280258 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01019812001 3522059 3538402 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019812001 3522059 3538402 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01019812001 3522059 3538402 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01019812001 3522059 3538402 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01019812001 3522059 3538402 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01017643001 2216358 2322673 GO:0008104 protein localization Any process by which a protein is transported to, or maintained in, a specific location. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01002646001 35576687 35585903 GSVIVG01004460001 38684265 38687835 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01004460001 38684265 38687835 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01032417001 27172992 27182437 GSVIVG01016175001 7055901 7061568 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01023246001 20631240 20635876 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01023246001 20631240 20635876 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01023246001 20631240 20635876 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01023246001 20631240 20635876 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023246001 20631240 20635876 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034323001 14903464 14904116 GSVIVG01033710001 18427577 18427678 GSVIVG01015445001 3757864 3762452 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01015445001 3757864 3762452 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01005922001 862777 863891 GSVIVG01038583001 21731310 21733916 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01038583001 21731310 21733916 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01038583001 21731310 21733916 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01016660001 184717 192376 Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. IEA GO:0004519 endonuclease activity GSVIVG01033016001 25074954 25078975 GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA GSVIVG01033016001 25074954 25078975 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01004634001 39244805 39246860 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01036094001 20755123 20756249 GSVIVG01033248001 22209722 22212130 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01037237001 17018309 17022252 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01037237001 17018309 17022252 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01020407001 19941484 19950657 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020407001 19941484 19950657 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01018699001 10997409 10997839 GSVIVG01005848001 22231511 22235358 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01005848001 22231511 22235358 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01005848001 22231511 22235358 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01005848001 22231511 22235358 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01005848001 22231511 22235358 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01005848001 22231511 22235358 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01005848001 22231511 22235358 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01005848001 22231511 22235358 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01019145001 16186696 16227869 GO:0051205 protein insertion into membrane The process by which a protein is incorporated into a biological membrane. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01034185001 14577287 14583517 GSVIVG01001120001 22768824 22774222 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01001120001 22768824 22774222 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01028588001 10291292 10291921 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with manganese (Mn) ions. IEA GO:0030145 manganese ion binding GSVIVG01028588001 10291292 10291921 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Functions in the storage of nutritious substrates. IEA GO:0045735 nutrient reservoir activity GSVIVG01021346001 4304344 4306352 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01021346001 4304344 4306352 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01000557001 7102261 7113695 GSVIVG01031738001 3944462 3947232 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01031738001 3944462 3947232 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01031738001 3944462 3947232 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01031738001 3944462 3947232 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031738001 3944462 3947232 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01031738001 3944462 3947232 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01031242001 914929 915362 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005746 mitochondrial respiratory chain The protein complexes that form the mitochondrial electron transport system (the respiratory chain), associated with the inner mitochondrial membrane. The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O. IEA GO:0004129 cytochrome-c oxidase activity GSVIVG01003756001 12387121 12415177 GO:0008643 carbohydrate transport The directed movement of carbohydrate into, out of, within or between cells by means of some external agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0000139 Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + H+(out) = sugar(in) + H+(in). IEA GO:0005351 sugar:hydrogen symporter activity GSVIVG01003756001 12387121 12415177 GO:0008643 carbohydrate transport The directed movement of carbohydrate into, out of, within or between cells by means of some external agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + H+(out) = sugar(in) + H+(in). IEA GO:0005351 sugar:hydrogen symporter activity GSVIVG01030495001 6182279 6189270 GO:0006094 gluconeogenesis The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: D-glucose 6-phosphate = D-fructose 6-phosphate. IEA GO:0004347 glucose-6-phosphate isomerase activity GSVIVG01030495001 6182279 6189270 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: D-glucose 6-phosphate = D-fructose 6-phosphate. IEA GO:0004347 glucose-6-phosphate isomerase activity GSVIVG01030495001 6182279 6189270 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: D-glucose 6-phosphate = D-fructose 6-phosphate. IEA GO:0004347 glucose-6-phosphate isomerase activity GSVIVG01030495001 6182279 6189270 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: D-glucose 6-phosphate = D-fructose 6-phosphate. IEA GO:0004347 glucose-6-phosphate isomerase activity GSVIVG01030495001 6182279 6189270 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: D-glucose 6-phosphate = D-fructose 6-phosphate. IEA GO:0004347 glucose-6-phosphate isomerase activity GSVIVG01030495001 6182279 6189270 GO:0006094 gluconeogenesis The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01030495001 6182279 6189270 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01030495001 6182279 6189270 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01030495001 6182279 6189270 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01030495001 6182279 6189270 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01030495001 6182279 6189270 GO:0006094 gluconeogenesis The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01030495001 6182279 6189270 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01030495001 6182279 6189270 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01030495001 6182279 6189270 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01030495001 6182279 6189270 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01030495001 6182279 6189270 GO:0006094 gluconeogenesis The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01030495001 6182279 6189270 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01030495001 6182279 6189270 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01030495001 6182279 6189270 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01030495001 6182279 6189270 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01006638001 27203086 27204588 Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01006638001 27203086 27204588 Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01001181001 1040116 1041329 GO:0006869 lipid transport The directed movement of lipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Interacting selectively and non-covalently with a lipid. IEA GO:0008289 lipid binding GSVIVG01001179001 1045426 1047109 GSVIVG01013670001 2308344 2332679 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01013670001 2308344 2332679 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01002098001 32920772 32933252 GSVIVG01010808001 22856751 22862502 GSVIVG01025091001 4580755 4584961 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01025091001 4580755 4584961 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01025091001 4580755 4584961 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli. IEA GO:0004707 MAP kinase activity GSVIVG01025091001 4580755 4584961 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01025091001 4580755 4584961 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001267001 4846174 4851433 GSVIVG01016631001 2332094 2338810 GSVIVG01010006001 13397962 13399162 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01010670001 15307914 15310917 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01010670001 15307914 15310917 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01010670001 15307914 15310917 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01010670001 15307914 15310917 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01025920001 27223834 27224243 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028091001 3730608 3732940 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01009807001 11409762 11411664 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004197 cysteine-type endopeptidase activity GSVIVG01009807001 11409762 11411664 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01022672001 14455264 14456243 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01009204001 6219119 6225014 GSVIVG01028722001 19447213 19454986 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01028722001 19447213 19454986 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01028722001 19447213 19454986 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028722001 19447213 19454986 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028722001 19447213 19454986 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01028722001 19447213 19454986 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01028722001 19447213 19454986 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01028722001 19447213 19454986 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01028722001 19447213 19454986 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01028722001 19447213 19454986 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01035103001 1481462 1483909 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01035103001 1481462 1483909 GO:0007047 cellular cell wall organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01035103001 1481462 1483909 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01035103001 1481462 1483909 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01035103001 1481462 1483909 GO:0007047 cellular cell wall organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01035103001 1481462 1483909 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01035103001 1481462 1483909 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01035103001 1481462 1483909 GO:0007047 cellular cell wall organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01035103001 1481462 1483909 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01023031001 16611886 16612725 GSVIVG01014436001 3738258 3741107 GSVIVG01013785001 7629296 7635442 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01013785001 7629296 7635442 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003848001 12812617 12822475 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01003848001 12812617 12822475 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01003848001 12812617 12822475 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01003848001 12812617 12822475 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01003848001 12812617 12822475 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014878001 11070438 11071450 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01014878001 11070438 11071450 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01014878001 11070438 11071450 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01014878001 11070438 11071450 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01025150001 3969957 3974873 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0005839 proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. IEA GO:0004175 endopeptidase activity GSVIVG01025150001 3969957 3974873 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0005839 proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. IEA Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. IEA GO:0004298 threonine-type endopeptidase activity GSVIVG01022462001 3319631 3329069 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030453001 5678707 5681171 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01030453001 5678707 5681171 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01030453001 5678707 5681171 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01030453001 5678707 5681171 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01024410001 2190839 2193532 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024410001 2190839 2193532 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: ATP + D-ribulose 5-phosphate = ADP + D-ribulose 1,5-bisphosphate. IEA GO:0008974 phosphoribulokinase activity GSVIVG01024410001 2190839 2193532 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01018220001 13050775 13072297 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: phosphatidylcholine + a sterol = a sterol ester + 1-acylglycerophosphocholine. IEA GO:0004607 phosphatidylcholine-sterol O-acyltransferase activity GSVIVG01005388001 40065354 40065964 GSVIVG01023897001 2604333 2609255 Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. IEA GO:0005089 Rho guanyl-nucleotide exchange factor activity GSVIVG01007738001 9713269 9720426 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GSVIVG01007738001 9713269 9720426 GO:0008037 cell recognition The process by which a cell in a multicellular organism interprets its surroundings. IEA GSVIVG01007738001 9713269 9720426 GO:0019058 viral infectious cycle A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome. IEA GSVIVG01017899001 4484044 4487627 GSVIVG01020050001 11124690 11127549 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01014224001 1646274 1651362 GO:0006278 RNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01014224001 1646274 1651362 GO:0006278 RNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01014224001 1646274 1651362 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01014224001 1646274 1651362 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01014224001 1646274 1651362 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01014224001 1646274 1651362 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01014224001 1646274 1651362 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01014224001 1646274 1651362 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01014224001 1646274 1651362 GO:0006278 RNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01014224001 1646274 1651362 GO:0006278 RNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01014224001 1646274 1651362 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01014224001 1646274 1651362 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01014224001 1646274 1651362 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01014224001 1646274 1651362 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01014224001 1646274 1651362 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01014224001 1646274 1651362 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01014224001 1646274 1651362 GO:0006278 RNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Interacting selectively and non-covalently with chromatin, the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase. IEA GO:0003682 chromatin binding GSVIVG01014224001 1646274 1651362 GO:0006278 RNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with chromatin, the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase. IEA GO:0003682 chromatin binding GSVIVG01014224001 1646274 1651362 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Interacting selectively and non-covalently with chromatin, the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase. IEA GO:0003682 chromatin binding GSVIVG01014224001 1646274 1651362 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with chromatin, the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase. IEA GO:0003682 chromatin binding GSVIVG01014224001 1646274 1651362 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Interacting selectively and non-covalently with chromatin, the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase. IEA GO:0003682 chromatin binding GSVIVG01014224001 1646274 1651362 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with chromatin, the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase. IEA GO:0003682 chromatin binding GSVIVG01014224001 1646274 1651362 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Interacting selectively and non-covalently with chromatin, the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase. IEA GO:0003682 chromatin binding GSVIVG01014224001 1646274 1651362 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with chromatin, the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase. IEA GO:0003682 chromatin binding GSVIVG01014224001 1646274 1651362 GO:0006278 RNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01014224001 1646274 1651362 GO:0006278 RNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01014224001 1646274 1651362 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01014224001 1646274 1651362 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01014224001 1646274 1651362 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01014224001 1646274 1651362 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01014224001 1646274 1651362 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01014224001 1646274 1651362 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01014224001 1646274 1651362 GO:0006278 RNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time. IEA GO:0003964 RNA-directed DNA polymerase activity GSVIVG01014224001 1646274 1651362 GO:0006278 RNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time. IEA GO:0003964 RNA-directed DNA polymerase activity GSVIVG01014224001 1646274 1651362 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time. IEA GO:0003964 RNA-directed DNA polymerase activity GSVIVG01014224001 1646274 1651362 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time. IEA GO:0003964 RNA-directed DNA polymerase activity GSVIVG01014224001 1646274 1651362 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time. IEA GO:0003964 RNA-directed DNA polymerase activity GSVIVG01014224001 1646274 1651362 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time. IEA GO:0003964 RNA-directed DNA polymerase activity GSVIVG01014224001 1646274 1651362 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time. IEA GO:0003964 RNA-directed DNA polymerase activity GSVIVG01014224001 1646274 1651362 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time. IEA GO:0003964 RNA-directed DNA polymerase activity GSVIVG01014224001 1646274 1651362 GO:0006278 RNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01014224001 1646274 1651362 GO:0006278 RNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01014224001 1646274 1651362 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01014224001 1646274 1651362 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01014224001 1646274 1651362 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01014224001 1646274 1651362 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01014224001 1646274 1651362 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01014224001 1646274 1651362 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01014224001 1646274 1651362 GO:0006278 RNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. IEA GO:0004519 endonuclease activity GSVIVG01014224001 1646274 1651362 GO:0006278 RNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. IEA GO:0004519 endonuclease activity GSVIVG01014224001 1646274 1651362 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. IEA GO:0004519 endonuclease activity GSVIVG01014224001 1646274 1651362 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. IEA GO:0004519 endonuclease activity GSVIVG01014224001 1646274 1651362 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. IEA GO:0004519 endonuclease activity GSVIVG01014224001 1646274 1651362 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. IEA GO:0004519 endonuclease activity GSVIVG01014224001 1646274 1651362 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. IEA GO:0004519 endonuclease activity GSVIVG01014224001 1646274 1651362 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. IEA GO:0004519 endonuclease activity GSVIVG01038412001 11954862 11957547 GO:0015671 oxygen transport The directed movement of oxygen (O2) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01038412001 11954862 11957547 GO:0015671 oxygen transport The directed movement of oxygen (O2) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with oxygen (O2). IEA GO:0019825 oxygen binding GSVIVG01038412001 11954862 11957547 GO:0015671 oxygen transport The directed movement of oxygen (O2) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01038085001 17731446 17757520 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01038085001 17731446 17757520 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01038085001 17731446 17757520 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01038085001 17731446 17757520 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01038085001 17731446 17757520 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01038085001 17731446 17757520 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01038085001 17731446 17757520 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01038085001 17731446 17757520 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01038085001 17731446 17757520 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01038085001 17731446 17757520 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01038085001 17731446 17757520 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01038085001 17731446 17757520 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01038085001 17731446 17757520 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01038085001 17731446 17757520 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01038085001 17731446 17757520 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01038085001 17731446 17757520 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01038085001 17731446 17757520 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01038085001 17731446 17757520 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01038085001 17731446 17757520 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01038085001 17731446 17757520 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01038085001 17731446 17757520 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038085001 17731446 17757520 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038085001 17731446 17757520 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038085001 17731446 17757520 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038085001 17731446 17757520 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038085001 17731446 17757520 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01038085001 17731446 17757520 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01038085001 17731446 17757520 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01038085001 17731446 17757520 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01038085001 17731446 17757520 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01003614001 11277296 11283422 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01011246001 10050925 10053220 GSVIVG01029860001 664973 669743 GSVIVG01016294001 5432137 5436480 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01016294001 5432137 5436480 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01016294001 5432137 5436480 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01016294001 5432137 5436480 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01016294001 5432137 5436480 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032385001 26857363 26862240 GO:0006012 galactose metabolic process The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + D-galactose = ADP + D-galactose 1-phosphate. IEA GO:0004335 galactokinase activity GSVIVG01032385001 26857363 26862240 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + D-galactose = ADP + D-galactose 1-phosphate. IEA GO:0004335 galactokinase activity GSVIVG01032385001 26857363 26862240 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + D-galactose = ADP + D-galactose 1-phosphate. IEA GO:0004335 galactokinase activity GSVIVG01032385001 26857363 26862240 GO:0046835 carbohydrate phosphorylation The process of introducing a phosphate group into a carbohydrate, any organic compound based on the general formula Cx(H2O)y. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + D-galactose = ADP + D-galactose 1-phosphate. IEA GO:0004335 galactokinase activity GSVIVG01032385001 26857363 26862240 GO:0006012 galactose metabolic process The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032385001 26857363 26862240 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032385001 26857363 26862240 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032385001 26857363 26862240 GO:0046835 carbohydrate phosphorylation The process of introducing a phosphate group into a carbohydrate, any organic compound based on the general formula Cx(H2O)y. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032385001 26857363 26862240 GO:0006012 galactose metabolic process The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01032385001 26857363 26862240 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01032385001 26857363 26862240 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01032385001 26857363 26862240 GO:0046835 carbohydrate phosphorylation The process of introducing a phosphate group into a carbohydrate, any organic compound based on the general formula Cx(H2O)y. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01032385001 26857363 26862240 GO:0006012 galactose metabolic process The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01032385001 26857363 26862240 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01032385001 26857363 26862240 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01032385001 26857363 26862240 GO:0046835 carbohydrate phosphorylation The process of introducing a phosphate group into a carbohydrate, any organic compound based on the general formula Cx(H2O)y. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01004606001 39208906 39209826 GSVIVG01030389001 5149717 5152215 GSVIVG01022608001 5958489 6009370 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01022608001 5958489 6009370 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01022608001 5958489 6009370 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022608001 5958489 6009370 Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01029158001 19013959 19015374 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01029158001 19013959 19015374 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01029158001 19013959 19015374 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01029158001 19013959 19015374 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01029158001 19013959 19015374 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01029158001 19013959 19015374 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01029158001 19013959 19015374 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01029158001 19013959 19015374 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01009987001 13133829 13157022 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01009987001 13133829 13157022 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01009987001 13133829 13157022 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01009987001 13133829 13157022 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01009987001 13133829 13157022 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01009987001 13133829 13157022 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01009987001 13133829 13157022 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01009987001 13133829 13157022 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01009987001 13133829 13157022 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01009987001 13133829 13157022 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01009987001 13133829 13157022 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01009987001 13133829 13157022 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01009987001 13133829 13157022 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01009987001 13133829 13157022 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01009987001 13133829 13157022 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01005966001 23008911 23013055 GSVIVG01036018001 7315581 7317297 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01010417001 20407223 20407948 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01010417001 20407223 20407948 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01010725001 21838652 21838943 GSVIVG01016082001 18581129 18582212 GSVIVG01012234001 339375 341595 GSVIVG01027393001 15320680 15327839 GSVIVG01015622001 14204863 14212245 GSVIVG01016900001 2387087 2388063 GSVIVG01008080001 5986034 5987215 GSVIVG01022202001 17421437 17423794 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027873001 8872247 8872642 GSVIVG01021626001 8352487 8368713 GSVIVG01034439001 16229878 16232598 GSVIVG01007336001 31421956 31428986 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01007336001 31421956 31428986 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016889001 2302102 2314053 GSVIVG01000112001 15358690 15361313 GO:0009416 response to light stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01000112001 15358690 15361313 GO:0009416 response to light stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016618001 2381344 2385018 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009654 oxygen evolving complex A complex, composed of a cluster of manganese, calcium and chloride ions bound to extrinsic proteins, that catalyzes the splitting of water to O2 and 4 H+. In cyanobacteria there are five extrinsic proteins in OEC (PsbO, PsbP-like, PsbQ-like, PsbU and PsbV), while in plants there are only three (PsbO, PsbP and PsbQ). IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01016618001 2381344 2385018 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0019898 extrinsic to membrane Loosely bound to one surface of a membrane, but not integrated into the hydrophobic region. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01010118001 15756276 15759027 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01036185001 19697513 19702041 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01028365001 6641415 6645665 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GSVIVG01009791001 11286578 11293205 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009791001 11286578 11293205 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009791001 11286578 11293205 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01009791001 11286578 11293205 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01009791001 11286578 11293205 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides. IEA GO:0004565 beta-galactosidase activity GSVIVG01009791001 11286578 11293205 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides. IEA GO:0004565 beta-galactosidase activity GSVIVG01009791001 11286578 11293205 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01009791001 11286578 11293205 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01009791001 11286578 11293205 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01009791001 11286578 11293205 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01009791001 11286578 11293205 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01009791001 11286578 11293205 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01009791001 11286578 11293205 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01009791001 11286578 11293205 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01016115001 19257788 19265261 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01016115001 19257788 19265261 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01016115001 19257788 19265261 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01016115001 19257788 19265261 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032800001 661823 664587 GSVIVG01030525001 6471567 6476560 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. IEA GO:0016853 isomerase activity GSVIVG01038174001 24065651 24067485 GO:0006631 fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01038174001 24065651 24067485 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01038174001 24065651 24067485 GO:0006631 fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. IEA Catalysis of the reaction: stearoyl-[acyl-carrier protein] + reduced acceptor + O2 = oleoyl-[acyl-carrier protein] + acceptor + H2O. The enzyme requires ferredoxin. IEA GO:0045300 acyl-[acyl-carrier-protein] desaturase activity GSVIVG01038174001 24065651 24067485 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: stearoyl-[acyl-carrier protein] + reduced acceptor + O2 = oleoyl-[acyl-carrier protein] + acceptor + H2O. The enzyme requires ferredoxin. IEA GO:0045300 acyl-[acyl-carrier-protein] desaturase activity GSVIVG01038174001 24065651 24067485 GO:0006631 fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01038174001 24065651 24067485 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01024419001 2333144 2334700 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01024419001 2333144 2334700 GO:0009718 anthocyanin biosynthetic process The chemical reactions and pathways resulting in the formation of anthocyanins, any member of a group of intensely colored soluble glycosides of anthocyanidins. IDA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01024419001 2333144 2334700 GO:0033303 quercetin O-glucoside biosynthetic process The chemical reactions and pathways leading to the formation of O-glucosylated derivatives of quercetin. IDA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01024419001 2333144 2334700 GO:0033330 kaempferol O-glucoside biosynthetic process The chemical reactions and pathways leading to the formation of O-glucosylated derivatives of kaempferol. IDA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01024419001 2333144 2334700 GO:0033485 cyanidin 3-O-glucoside biosynthetic process The chemical reactions and pathways resulting in the formation of cyanidin 3-O-glucoside, a basic anthocyanin responsible for red to magenta coloration of flowers and fruits. IDA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01024419001 2333144 2334700 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01024419001 2333144 2334700 GO:0009718 anthocyanin biosynthetic process The chemical reactions and pathways resulting in the formation of anthocyanins, any member of a group of intensely colored soluble glycosides of anthocyanidins. IDA Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01024419001 2333144 2334700 GO:0033303 quercetin O-glucoside biosynthetic process The chemical reactions and pathways leading to the formation of O-glucosylated derivatives of quercetin. IDA Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01024419001 2333144 2334700 GO:0033330 kaempferol O-glucoside biosynthetic process The chemical reactions and pathways leading to the formation of O-glucosylated derivatives of kaempferol. IDA Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01024419001 2333144 2334700 GO:0033485 cyanidin 3-O-glucoside biosynthetic process The chemical reactions and pathways resulting in the formation of cyanidin 3-O-glucoside, a basic anthocyanin responsible for red to magenta coloration of flowers and fruits. IDA Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01024419001 2333144 2334700 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01024419001 2333144 2334700 GO:0009718 anthocyanin biosynthetic process The chemical reactions and pathways resulting in the formation of anthocyanins, any member of a group of intensely colored soluble glycosides of anthocyanidins. IDA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01024419001 2333144 2334700 GO:0033303 quercetin O-glucoside biosynthetic process The chemical reactions and pathways leading to the formation of O-glucosylated derivatives of quercetin. IDA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01024419001 2333144 2334700 GO:0033330 kaempferol O-glucoside biosynthetic process The chemical reactions and pathways leading to the formation of O-glucosylated derivatives of kaempferol. IDA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01024419001 2333144 2334700 GO:0033485 cyanidin 3-O-glucoside biosynthetic process The chemical reactions and pathways resulting in the formation of cyanidin 3-O-glucoside, a basic anthocyanin responsible for red to magenta coloration of flowers and fruits. IDA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01024419001 2333144 2334700 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: anthocyanidin + UDP-D-glucose = anthocyanidin-3-O-D-glucoside + UDP. IEA GO:0047213 anthocyanidin 3-O-glucosyltransferase activity GSVIVG01024419001 2333144 2334700 GO:0009718 anthocyanin biosynthetic process The chemical reactions and pathways resulting in the formation of anthocyanins, any member of a group of intensely colored soluble glycosides of anthocyanidins. IDA Catalysis of the reaction: anthocyanidin + UDP-D-glucose = anthocyanidin-3-O-D-glucoside + UDP. IEA GO:0047213 anthocyanidin 3-O-glucosyltransferase activity GSVIVG01024419001 2333144 2334700 GO:0033303 quercetin O-glucoside biosynthetic process The chemical reactions and pathways leading to the formation of O-glucosylated derivatives of quercetin. IDA Catalysis of the reaction: anthocyanidin + UDP-D-glucose = anthocyanidin-3-O-D-glucoside + UDP. IEA GO:0047213 anthocyanidin 3-O-glucosyltransferase activity GSVIVG01024419001 2333144 2334700 GO:0033330 kaempferol O-glucoside biosynthetic process The chemical reactions and pathways leading to the formation of O-glucosylated derivatives of kaempferol. IDA Catalysis of the reaction: anthocyanidin + UDP-D-glucose = anthocyanidin-3-O-D-glucoside + UDP. IEA GO:0047213 anthocyanidin 3-O-glucosyltransferase activity GSVIVG01024419001 2333144 2334700 GO:0033485 cyanidin 3-O-glucoside biosynthetic process The chemical reactions and pathways resulting in the formation of cyanidin 3-O-glucoside, a basic anthocyanin responsible for red to magenta coloration of flowers and fruits. IDA Catalysis of the reaction: anthocyanidin + UDP-D-glucose = anthocyanidin-3-O-D-glucoside + UDP. IEA GO:0047213 anthocyanidin 3-O-glucosyltransferase activity GSVIVG01033833001 17366908 17369085 GSVIVG01021870001 6240892 6243400 GO:0006535 cysteine biosynthetic process from serine The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021870001 6240892 6243400 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021870001 6240892 6243400 GO:0006535 cysteine biosynthetic process from serine The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine. IEA Catalysis of the reaction: O3-acetyl-L-serine + H2S = L-cysteine + acetate. IEA GO:0004124 cysteine synthase activity GSVIVG01021870001 6240892 6243400 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: O3-acetyl-L-serine + H2S = L-cysteine + acetate. IEA GO:0004124 cysteine synthase activity GSVIVG01021870001 6240892 6243400 GO:0006535 cysteine biosynthetic process from serine The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01021870001 6240892 6243400 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01034406001 16787174 16794026 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01034406001 16787174 16794026 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01034406001 16787174 16794026 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01034406001 16787174 16794026 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01034406001 16787174 16794026 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01034406001 16787174 16794026 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01034406001 16787174 16794026 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034406001 16787174 16794026 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001486001 5041002 5059747 GSVIVG01004080001 14654524 14656341 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01002899001 37104299 37106562 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01018808001 19688493 19690839 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01018808001 19688493 19690839 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01018808001 19688493 19690839 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01015068001 812552 813288 GSVIVG01011489001 30008365 30011357 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01011489001 30008365 30011357 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008128001 5544535 5548284 Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01011092001 1670952 1674475 GSVIVG01011764001 4368173 4385106 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01011764001 4368173 4385106 GO:0046488 phosphatidylinositol metabolic process The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01011764001 4368173 4385106 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011764001 4368173 4385106 GO:0046488 phosphatidylinositol metabolic process The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011764001 4368173 4385106 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01011764001 4368173 4385106 GO:0046488 phosphatidylinositol metabolic process The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01011764001 4368173 4385106 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA Catalysis of the phosphorylation of phosphatidylinositol phosphate to produce phosphatidylinositol bisphosphate. IEA GO:0016307 phosphatidylinositol phosphate kinase activity GSVIVG01011764001 4368173 4385106 GO:0046488 phosphatidylinositol metabolic process The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. IEA Catalysis of the phosphorylation of phosphatidylinositol phosphate to produce phosphatidylinositol bisphosphate. IEA GO:0016307 phosphatidylinositol phosphate kinase activity GSVIVG01023091001 15473622 15474078 GSVIVG01019089001 16801744 16809442 GO:0008299 isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. IEA Catalysis of the reaction: isopentenyl diphosphate = dimethylallyl diphosphate. IEA GO:0004452 isopentenyl-diphosphate delta-isomerase activity GSVIVG01019089001 16801744 16809442 GO:0008299 isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01018764001 20106572 20111180 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GSVIVG01005908001 739203 740078 GSVIVG01035801001 4478872 4485156 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01035801001 4478872 4485156 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01035801001 4478872 4485156 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01035801001 4478872 4485156 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01035801001 4478872 4485156 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01035801001 4478872 4485156 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01035801001 4478872 4485156 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01035801001 4478872 4485156 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01035801001 4478872 4485156 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01035801001 4478872 4485156 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01035801001 4478872 4485156 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01035801001 4478872 4485156 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01035801001 4478872 4485156 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01035801001 4478872 4485156 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01035801001 4478872 4485156 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01035801001 4478872 4485156 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01022916001 18100795 18103247 Functions in the storage of nutritious substrates. IEA GO:0045735 nutrient reservoir activity GSVIVG01034714001 8271939 8272577 GSVIVG01008469001 1666197 1668095 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01011007001 2266231 2276913 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01011007001 2266231 2276913 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01011007001 2266231 2276913 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01011007001 2266231 2276913 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0008236 serine-type peptidase activity GSVIVG01022882001 18404123 18440210 GSVIVG01038078001 17510564 17514626 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01038078001 17510564 17514626 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01038078001 17510564 17514626 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0010181 FMN binding GSVIVG01038078001 17510564 17514626 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0010181 FMN binding GSVIVG01038078001 17510564 17514626 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01038078001 17510564 17514626 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025651001 13306902 13308155 GSVIVG01038111001 23549425 23550388 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01038111001 23549425 23550388 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01038111001 23549425 23550388 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01029453001 22693377 22694610 GSVIVG01008922001 3412345 3414417 GSVIVG01025013001 5289200 5295248 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025013001 5289200 5295248 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025013001 5289200 5295248 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025013001 5289200 5295248 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025013001 5289200 5295248 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01025013001 5289200 5295248 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01025013001 5289200 5295248 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025013001 5289200 5295248 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01019284001 2008819 2012880 Catalysis of the transfer of the amide nitrogen of glutamine to a variety of substrates. GATases catalyze two separate reactions at two active sites, which are located either on a single polypeptide chain or on different subunits. In the glutaminase reaction, glutamine is hydrolyzed to glutamate and ammonia, which is added to an acceptor substrate in the synthase reaction. IEA GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor GSVIVG01001310001 5221960 5224224 GSVIVG01037884001 6773155 6775422 GSVIVG01027137001 17534478 17535281 GSVIVG01032942001 24482249 24484758 GO:0006006 glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032942001 24482249 24484758 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032942001 24482249 24484758 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032942001 24482249 24484758 GO:0006006 glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. IEA Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+. IEA GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity GSVIVG01032942001 24482249 24484758 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+. IEA GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity GSVIVG01032942001 24482249 24484758 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+. IEA GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity GSVIVG01032942001 24482249 24484758 GO:0006006 glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032942001 24482249 24484758 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032942001 24482249 24484758 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032942001 24482249 24484758 GO:0006006 glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01032942001 24482249 24484758 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01032942001 24482249 24484758 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01036825001 17544607 17552354 GSVIVG01026874001 19711339 19729106 GSVIVG01001722001 516694 517653 GSVIVG01017390001 7787686 7796453 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032849001 270230 270989 GSVIVG01007853001 8359461 8366696 GSVIVG01021770001 10886899 10887762 GSVIVG01014471001 4194434 4200262 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01031899001 5243539 5244774 GSVIVG01033910001 16808902 16815102 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033910001 16808902 16815102 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033910001 16808902 16815102 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033910001 16808902 16815102 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033910001 16808902 16815102 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033910001 16808902 16815102 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01017255001 5954825 5956961 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01017255001 5954825 5956961 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01017255001 5954825 5956961 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01015797001 17540698 17561239 GSVIVG01008863001 2885810 2894159 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01001620001 21422015 21422393 GSVIVG01000073001 3221376 3234013 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000073001 3221376 3234013 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01000073001 3221376 3234013 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01001723001 517693 518213 GSVIVG01001807001 25980889 25981933 Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01001807001 25980889 25981933 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01021698001 9744910 9746882 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032860001 156285 166911 GO:0031227 intrinsic to endoplasmic reticulum membrane Located in the endoplasmic reticulum membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01032574001 28486389 28490785 GSVIVG01036865001 18515321 18524865 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01026155001 13085340 13092118 GSVIVG01009157001 5622529 5628323 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA GSVIVG01008058001 6173381 6176410 GSVIVG01001099001 22634728 22637919 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GSVIVG01027912001 9307254 9318342 GSVIVG01026015001 25838001 25839742 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. IEA GO:0008080 N-acetyltransferase activity GSVIVG01004456001 38653791 38654627 GSVIVG01032769001 896928 917652 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01032769001 896928 917652 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032769001 896928 917652 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030426001 5472811 5474327 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01030426001 5472811 5474327 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01020568001 4227744 4234100 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01020568001 4227744 4234100 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01020568001 4227744 4234100 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01020568001 4227744 4234100 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033909001 16816948 16820486 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033909001 16816948 16820486 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033909001 16816948 16820486 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008237 metallopeptidase activity GSVIVG01033909001 16816948 16820486 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008237 metallopeptidase activity GSVIVG01033909001 16816948 16820486 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01033909001 16816948 16820486 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01033909001 16816948 16820486 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01033909001 16816948 16820486 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01025837001 11367701 11377205 GSVIVG01023846001 3025509 3027713 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01023846001 3025509 3027713 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01023846001 3025509 3027713 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01023846001 3025509 3027713 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01023846001 3025509 3027713 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010751001 22146323 22160776 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025223001 3073921 3076705 GSVIVG01022275001 18080106 18092902 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01022275001 18080106 18092902 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01022275001 18080106 18092902 GO:0009060 aerobic respiration The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01022275001 18080106 18092902 GO:0009060 aerobic respiration The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01022275001 18080106 18092902 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01022275001 18080106 18092902 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01022275001 18080106 18092902 GO:0009060 aerobic respiration The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01022275001 18080106 18092902 GO:0009060 aerobic respiration The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01022275001 18080106 18092902 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01022275001 18080106 18092902 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01022275001 18080106 18092902 GO:0009060 aerobic respiration The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01022275001 18080106 18092902 GO:0009060 aerobic respiration The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01022275001 18080106 18092902 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01022275001 18080106 18092902 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01022275001 18080106 18092902 GO:0009060 aerobic respiration The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01022275001 18080106 18092902 GO:0009060 aerobic respiration The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01022275001 18080106 18092902 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01022275001 18080106 18092902 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01022275001 18080106 18092902 GO:0009060 aerobic respiration The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01022275001 18080106 18092902 GO:0009060 aerobic respiration The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01034036001 15675129 15682395 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with neuropeptide Y to initiate a change in cell activity. IEA GO:0004983 neuropeptide Y receptor activity GSVIVG01025877001 27602438 27608757 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025877001 27602438 27608757 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025877001 27602438 27608757 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025877001 27602438 27608757 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025877001 27602438 27608757 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01025877001 27602438 27608757 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01025877001 27602438 27608757 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01025877001 27602438 27608757 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01025877001 27602438 27608757 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025877001 27602438 27608757 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025877001 27602438 27608757 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025877001 27602438 27608757 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025877001 27602438 27608757 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01025877001 27602438 27608757 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01025877001 27602438 27608757 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01025877001 27602438 27608757 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01008544001 967651 972345 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008544001 967651 972345 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008544001 967651 972345 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01012376001 259480 260270 GSVIVG01037302001 16134895 16137832 GO:0008299 isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. IEA GSVIVG01027547001 15795085 15857100 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01027547001 15795085 15857100 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01012796001 23148708 23151663 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012796001 23148708 23151663 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008047001 6290105 6305763 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008047001 6290105 6305763 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024223001 69711 76504 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019766001 3140924 3144145 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: 2 glutathione + H2O2 = oxidized glutathione + 2 H2O. IEA GO:0004602 glutathione peroxidase activity GSVIVG01019766001 3140924 3144145 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2 glutathione + H2O2 = oxidized glutathione + 2 H2O. IEA GO:0004602 glutathione peroxidase activity GSVIVG01019766001 3140924 3144145 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01019766001 3140924 3144145 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01010114001 15713490 15721119 GSVIVG01014525001 4811257 4812384 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014525001 4811257 4812384 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014525001 4811257 4812384 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014525001 4811257 4812384 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008661001 47471 51961 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01038316001 12717830 12719569 GSVIVG01038476001 10091914 10092024 GSVIVG01037651001 6551525 6553699 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01037651001 6551525 6553699 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01017354001 7142261 7142744 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01028012001 3188136 3192205 GSVIVG01020805001 1745863 1766246 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01020805001 1745863 1766246 GO:0009725 response to hormone stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01020805001 1745863 1766246 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01020805001 1745863 1766246 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01020805001 1745863 1766246 GO:0009725 response to hormone stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01020805001 1745863 1766246 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01021705001 9826675 9827694 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with manganese (Mn) ions. IEA GO:0030145 manganese ion binding GSVIVG01021705001 9826675 9827694 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Functions in the storage of nutritious substrates. IEA GO:0045735 nutrient reservoir activity GSVIVG01018335001 10879612 10887383 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01018335001 10879612 10887383 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01012445001 853550 864507 GSVIVG01005826001 297940 311075 GSVIVG01036327001 3865411 3865795 Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01036327001 3865411 3865795 Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01005106001 18167342 18167599 GSVIVG01029905001 1274116 1282446 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Stimulates the hydrolysis and exchange of adenyl nucleotides by other proteins. IEA GO:0000774 adenyl-nucleotide exchange factor activity GSVIVG01029905001 1274116 1282446 GO:0030150 protein import into mitochondrial matrix The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Stimulates the hydrolysis and exchange of adenyl nucleotides by other proteins. IEA GO:0000774 adenyl-nucleotide exchange factor activity GSVIVG01029905001 1274116 1282446 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029905001 1274116 1282446 GO:0030150 protein import into mitochondrial matrix The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029905001 1274116 1282446 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with an identical protein to form a homodimer. IEA GO:0042803 protein homodimerization activity GSVIVG01029905001 1274116 1282446 GO:0030150 protein import into mitochondrial matrix The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with an identical protein to form a homodimer. IEA GO:0042803 protein homodimerization activity GSVIVG01029905001 1274116 1282446 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport. IEA GO:0051087 chaperone binding GSVIVG01029905001 1274116 1282446 GO:0030150 protein import into mitochondrial matrix The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport. IEA GO:0051087 chaperone binding GSVIVG01014272001 2219866 2232444 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01033366001 21184523 21185837 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01033366001 21184523 21185837 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01033366001 21184523 21185837 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01033366001 21184523 21185837 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01001428001 19034333 19051176 Catalysis of the removal of a phosphate group from phosphorylated myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol. IEA GO:0004437 inositol or phosphatidylinositol phosphatase activity GSVIVG01034361001 17403377 17405667 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01015209001 1845503 1850190 GSVIVG01014601001 5485499 5486468 GSVIVG01008082001 5968993 5974041 GSVIVG01016965001 3018176 3020045 GSVIVG01013853001 5234832 5316204 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01013853001 5234832 5316204 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate, driving the unwinding of the DNA helix. IEA GO:0004003 ATP-dependent DNA helicase activity GSVIVG01013853001 5234832 5316204 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013853001 5234832 5316204 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01037928001 11051040 11068501 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01010343001 19653032 19663798 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01010343001 19653032 19663798 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010343001 19653032 19663798 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01017515001 9800120 9800332 GSVIVG01000380001 371956 379989 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01022021001 4219953 4228255 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01022021001 4219953 4228255 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01022021001 4219953 4228255 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01022021001 4219953 4228255 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017225001 5644160 5649078 GSVIVG01013349001 12511585 12531527 GO:0007205 activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway The initiation of the activity of the inactive enzyme protein kinase C as the result of a series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol 3-phosphate. IEA GO:0004143 diacylglycerol kinase activity GSVIVG01019302001 1639701 1645156 GSVIVG01009727001 10825952 10827452 GSVIVG01000148001 15648135 15655768 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01000148001 15648135 15655768 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt. IEA GO:0004525 ribonuclease III activity GSVIVG01000511001 13295414 13296045 GSVIVG01032604001 28771660 28775968 GSVIVG01032456001 27611195 27619456 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA GSVIVG01011361001 28951450 28954840 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GSVIVG01031267001 681586 686193 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027692001 14260533 14261342 GSVIVG01031562001 18164476 18165829 GSVIVG01028519001 9070168 9081446 GSVIVG01013845001 5159344 5162487 GO:0006729 tetrahydrobiopterin biosynthetic process The chemical reactions and pathways resulting in the formation of tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine. IEA Catalysis of the reaction: (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4-alpha-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H2O. IEA GO:0008124 4-alpha-hydroxytetrahydrobiopterin dehydratase activity GSVIVG01034073001 15380687 15387772 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01034073001 15380687 15387772 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01034073001 15380687 15387772 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01034073001 15380687 15387772 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01034073001 15380687 15387772 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01034073001 15380687 15387772 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01013700001 2790344 2791511 GSVIVG01003392001 9838037 9840134 GSVIVG01033415001 20881460 20884123 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01033415001 20881460 20884123 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01033415001 20881460 20884123 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01033415001 20881460 20884123 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01033415001 20881460 20884123 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01033415001 20881460 20884123 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01033415001 20881460 20884123 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01033415001 20881460 20884123 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01033415001 20881460 20884123 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01033415001 20881460 20884123 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01033415001 20881460 20884123 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01033415001 20881460 20884123 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01033415001 20881460 20884123 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01033415001 20881460 20884123 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01033415001 20881460 20884123 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01033415001 20881460 20884123 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01033415001 20881460 20884123 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01033415001 20881460 20884123 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01033415001 20881460 20884123 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01033415001 20881460 20884123 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01033415001 20881460 20884123 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01033415001 20881460 20884123 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01033415001 20881460 20884123 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01033415001 20881460 20884123 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01033415001 20881460 20884123 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01033415001 20881460 20884123 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01033415001 20881460 20884123 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01023471001 11326507 11334750 GSVIVG01008105001 5754827 5759137 GSVIVG01025288001 2414216 2424115 GSVIVG01035992001 6907775 6914715 GO:0006011 UDP-glucose metabolic process The chemical reactions and pathways involving UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: nucleoside-disphosphate-glucose + ((1,4)-beta-D-glucosyl)(n) = nucleoside-disphosphate + ((1,4)-beta-D-glucosyl)(n+1). IEA GO:0016759 cellulose synthase activity GSVIVG01027093001 17990229 17992911 GSVIVG01008553001 922600 925171 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01008553001 922600 925171 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01008553001 922600 925171 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01008553001 922600 925171 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01008553001 922600 925171 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01008553001 922600 925171 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01036491001 22625125 22637108 GSVIVG01036370001 4307867 4309046 Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01036370001 4307867 4309046 Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01029938001 1771069 1774493 GSVIVG01009580001 9603165 9606416 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0008236 serine-type peptidase activity GSVIVG01009580001 9603165 9606416 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0008236 serine-type peptidase activity GSVIVG01037804001 7741936 7749302 GSVIVG01014639001 8107460 8115536 Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01037799001 7826669 7826884 GSVIVG01036652001 19868745 19874626 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01027949001 9921390 9922390 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025300001 2311711 2335157 GO:0001539 ciliary or flagellar motility Cell motility due to movement of cilia or flagella. IEA GO:0009428 bacterial-type flagellum basal body, distal rod, P ring One of the rings of the flagellar basal body; anchors the basal body to the peptidoglycan layer. Examples of this component are found in bacteria. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01025300001 2311711 2335157 GO:0001539 ciliary or flagellar motility Cell motility due to movement of cilia or flagella. IEA GO:0019867 outer membrane The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01025300001 2311711 2335157 GO:0001539 ciliary or flagellar motility Cell motility due to movement of cilia or flagella. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01031251001 789394 791718 GSVIVG01032150001 22089588 22102389 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029483001 22356599 22366380 GSVIVG01010709001 12223289 12223717 GSVIVG01030323001 8885665 8885931 GSVIVG01019743001 2890638 2893841 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01019743001 2890638 2893841 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01019743001 2890638 2893841 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01019743001 2890638 2893841 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01009432001 8294896 8296810 GO:0007049 cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01009432001 8294896 8296810 GO:0051301 cell division The process resulting in the physical partitioning and separation of a cell into daughter cells. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01027202001 18401680 18412907 GSVIVG01003930001 13887659 13895185 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000494001 14954549 14957701 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01000494001 14954549 14957701 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01000494001 14954549 14957701 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01000494001 14954549 14957701 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01000494001 14954549 14957701 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01000494001 14954549 14957701 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01030488001 6115199 6119855 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01030488001 6115199 6119855 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01030488001 6115199 6119855 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01030488001 6115199 6119855 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01030488001 6115199 6119855 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01030488001 6115199 6119855 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01030488001 6115199 6119855 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01030488001 6115199 6119855 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01017829001 3842708 3844012 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01017829001 3842708 3844012 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01017829001 3842708 3844012 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01017829001 3842708 3844012 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01015356001 2943205 2947862 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01015356001 2943205 2947862 GO:0051260 protein homooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01038696001 20893114 20900760 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion. IEA GO:0004806 triglyceride lipase activity GSVIVG01037697001 7014972 7045143 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01020177001 9395440 9397294 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01025453001 738669 743021 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA Catalysis of the reaction: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA. IEA GO:0004045 aminoacyl-tRNA hydrolase activity GSVIVG01010842001 23297175 23305154 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01010842001 23297175 23305154 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01000849001 2898591 2899388 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01025773001 12047460 12058453 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01025773001 12047460 12058453 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025773001 12047460 12058453 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01025773001 12047460 12058453 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025773001 12047460 12058453 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01025773001 12047460 12058453 Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. IEA GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GSVIVG01017332001 6811010 6817803 Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01017332001 6811010 6817803 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01030521001 6432631 6438818 GSVIVG01003651001 11733680 11733751 GSVIVG01009660001 10271071 10272232 GO:0016559 peroxisome fission The division of a mature peroxisome within a cell to form two or more separate peroxisome compartments. IEA GO:0005778 peroxisomal membrane The lipid bilayer surrounding a peroxisome. IEA GSVIVG01036540001 23215918 23223907 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01036540001 23215918 23223907 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01036540001 23215918 23223907 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01036540001 23215918 23223907 GO:0042254 ribosome biogenesis The process of the formation of the constituents of the ribosome subunits, their assembly, and their transport to the sites of protein synthesis. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01036540001 23215918 23223907 GO:0042254 ribosome biogenesis The process of the formation of the constituents of the ribosome subunits, their assembly, and their transport to the sites of protein synthesis. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01036540001 23215918 23223907 GO:0042254 ribosome biogenesis The process of the formation of the constituents of the ribosome subunits, their assembly, and their transport to the sites of protein synthesis. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01031149001 1707947 1713923 GSVIVG01005707001 21419370 21421350 GSVIVG01016569001 2698670 2704723 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01016569001 2698670 2704723 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01009607001 9828012 9838662 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01009607001 9828012 9838662 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01009607001 9828012 9838662 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01009607001 9828012 9838662 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01032145001 22194493 22195485 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01008234001 4343550 4345620 GSVIVG01027606001 15093352 15102703 GSVIVG01036175001 19814619 19814991 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01036175001 19814619 19814991 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033893001 16953677 16959264 GSVIVG01018950001 18428528 18430772 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035813001 4564494 4575191 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). IEA GO:0003755 peptidyl-prolyl cis-trans isomerase activity GSVIVG01031226001 1047029 1048839 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA GSVIVG01019928001 4511891 4534148 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01019928001 4511891 4534148 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019928001 4511891 4534148 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033593001 19467805 19471948 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024359001 1412099 1428570 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01024227001 2918 5568 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01024227001 2918 5568 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01024227001 2918 5568 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024227001 2918 5568 Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01020698001 3036634 3037780 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004197 cysteine-type endopeptidase activity GSVIVG01020698001 3036634 3037780 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01009420001 8201566 8203207 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01009420001 8201566 8203207 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016293001 5456052 5458524 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01016293001 5456052 5458524 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01016293001 5456052 5458524 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01016293001 5456052 5458524 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036976001 9349142 9352616 GSVIVG01018147001 13903826 13904404 GSVIVG01009688001 10490461 10500127 GSVIVG01011638001 5681625 5683551 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01013475001 93654 95299 Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01034129001 14979078 14980110 GSVIVG01021339001 4245989 4247817 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01021339001 4245989 4247817 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01013193001 6896649 6900386 GSVIVG01020776001 2120069 2142597 GSVIVG01013352001 12545279 12548214 GSVIVG01030041001 9076765 9076929 GSVIVG01024288001 567771 569970 GSVIVG01020295001 21764901 21766518 GSVIVG01032043001 23261070 23262856 GSVIVG01003698001 15283280 15290377 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01012140001 1098379 1102698 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012140001 1098379 1102698 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012140001 1098379 1102698 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008237 metallopeptidase activity GSVIVG01012140001 1098379 1102698 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008237 metallopeptidase activity GSVIVG01012140001 1098379 1102698 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01012140001 1098379 1102698 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01012140001 1098379 1102698 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amidine, a compound of the form R-C(=NH)-NH2. IEA GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines GSVIVG01012140001 1098379 1102698 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amidine, a compound of the form R-C(=NH)-NH2. IEA GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines GSVIVG01012140001 1098379 1102698 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01012140001 1098379 1102698 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01026026001 25655818 25656549 GSVIVG01025147001 3983742 3984762 Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01016937001 2728009 2740198 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01016937001 2728009 2740198 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01016937001 2728009 2740198 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01016937001 2728009 2740198 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016937001 2728009 2740198 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016101001 18991795 19000495 GSVIVG01018723001 20391434 20391823 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01013085001 8527798 8532588 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01036919001 17609690 17614854 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with a thromboxane (TXA) to initiate a change in cell activity. IEA GO:0004960 thromboxane receptor activity GSVIVG01036919001 17609690 17614854 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with a thromboxane (TXA) to initiate a change in cell activity. IEA GO:0004960 thromboxane receptor activity GSVIVG01035055001 1232005 1232967 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GSVIVG01035055001 1232005 1232967 GO:0009607 response to biotic stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism. IEA GSVIVG01025287001 2429832 2430762 GSVIVG01016285001 5546187 5548879 GSVIVG01012028001 2080595 2083941 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other. IEA GO:0005337 nucleoside transmembrane transporter activity GSVIVG01014264001 2124049 2125945 GSVIVG01012092001 1547239 1548537 GSVIVG01028905001 17674547 17676106 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028905001 17674547 17676106 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028905001 17674547 17676106 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01028423001 7413963 7421387 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01013563001 20915175 20938514 GO:0000245 spliceosome assembly The aggregation, arrangement and bonding together of the spliceosome, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions. IEA GSVIVG01013563001 20915175 20938514 GO:0000398 nuclear mRNA splicing, via spliceosome The joining together of exons from one or more primary transcripts of nuclear messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. IEA GSVIVG01013439001 447136 470607 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01005038001 17564910 17571491 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01005038001 17564910 17571491 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01005038001 17564910 17571491 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01005038001 17564910 17571491 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01005038001 17564910 17571491 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with single-stranded DNA. IEA GO:0003697 single-stranded DNA binding GSVIVG01005038001 17564910 17571491 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with single-stranded DNA. IEA GO:0003697 single-stranded DNA binding GSVIVG01005038001 17564910 17571491 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01005038001 17564910 17571491 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01005038001 17564910 17571491 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate in the presence of single- or double-stranded DNA; drives another reaction. IEA GO:0008094 DNA-dependent ATPase activity GSVIVG01005038001 17564910 17571491 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate in the presence of single- or double-stranded DNA; drives another reaction. IEA GO:0008094 DNA-dependent ATPase activity GSVIVG01005038001 17564910 17571491 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01005038001 17564910 17571491 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01031896001 5234028 5235506 GSVIVG01028213001 4670371 4674928 GSVIVG01024058001 1443096 1447485 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01035901001 5518759 5591661 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01035901001 5518759 5591661 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01035901001 5518759 5591661 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035901001 5518759 5591661 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035901001 5518759 5591661 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Interacting selectively and non-covalently with chromatin, the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase. IEA GO:0003682 chromatin binding GSVIVG01035901001 5518759 5591661 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with chromatin, the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase. IEA GO:0003682 chromatin binding GSVIVG01035901001 5518759 5591661 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01035901001 5518759 5591661 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01035901001 5518759 5591661 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035901001 5518759 5591661 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035901001 5518759 5591661 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035901001 5518759 5591661 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035901001 5518759 5591661 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01035901001 5518759 5591661 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01035901001 5518759 5591661 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01035901001 5518759 5591661 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01035901001 5518759 5591661 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01035901001 5518759 5591661 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01035901001 5518759 5591661 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01035901001 5518759 5591661 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01007700001 10240920 10241875 GSVIVG01013048001 9220341 9222116 GSVIVG01023105001 22531017 22539454 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01023105001 22531017 22539454 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01023105001 22531017 22539454 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01023105001 22531017 22539454 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01023105001 22531017 22539454 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01023105001 22531017 22539454 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01023105001 22531017 22539454 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01023105001 22531017 22539454 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01012095001 1529723 1536715 GSVIVG01001838001 26211555 26211752 GSVIVG01035651001 2998630 3016695 GSVIVG01028062001 3524633 3531334 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01028062001 3524633 3531334 GO:0031032 actomyosin structure organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01028062001 3524633 3531334 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01028062001 3524633 3531334 GO:0031032 actomyosin structure organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01028062001 3524633 3531334 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028062001 3524633 3531334 GO:0031032 actomyosin structure organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008164001 5177472 5186799 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01016553001 2859227 2862204 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016553001 2859227 2862204 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01016553001 2859227 2862204 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01030257001 9808508 9813697 GSVIVG01015469001 3975392 3976209 GSVIVG01008295001 3540737 3546974 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014566001 5225078 5232195 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01014566001 5225078 5232195 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01033037001 25246234 25251029 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01033037001 25246234 25251029 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01033037001 25246234 25251029 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01033037001 25246234 25251029 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037467001 13202513 13215893 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01037467001 13202513 13215893 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01037467001 13202513 13215893 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01037467001 13202513 13215893 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01037467001 13202513 13215893 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01037467001 13202513 13215893 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01037467001 13202513 13215893 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01037467001 13202513 13215893 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01037467001 13202513 13215893 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01037467001 13202513 13215893 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01037467001 13202513 13215893 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01037467001 13202513 13215893 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01015486001 4116121 4119764 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01010212001 17594007 17595167 GSVIVG01001212001 742591 743492 GSVIVG01011621001 5836230 5846190 GSVIVG01032010001 23581736 23595372 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032010001 23581736 23595372 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01032010001 23581736 23595372 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01005843001 22200422 22201589 GSVIVG01035417001 1133490 1141654 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01035417001 1133490 1141654 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01029813001 15200513 15201190 GSVIVG01037593001 10243165 10268117 GO:0019867 outer membrane The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites. IEA GSVIVG01029521001 22019105 22019290 GSVIVG01016490001 3444003 3452360 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01016490001 3444003 3452360 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01016490001 3444003 3452360 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01016490001 3444003 3452360 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01016490001 3444003 3452360 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016490001 3444003 3452360 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016490001 3444003 3452360 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01016490001 3444003 3452360 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01035137001 1782798 1783564 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01035137001 1782798 1783564 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N2-methylguanine. IEA GO:0004809 tRNA (guanine-N2-)-methyltransferase activity GSVIVG01036266001 7807797 7807871 GSVIVG01031689001 20219550 20228364 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01031689001 20219550 20228364 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01036862001 18560293 18594852 GSVIVG01036331001 3880237 3881495 Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01036331001 3880237 3881495 Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01010989001 2395118 2395390 GSVIVG01036809001 16506973 16507131 GSVIVG01035479001 1596631 1632504 GO:0016459 myosin complex A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01035479001 1596631 1632504 GO:0016459 myosin complex A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. IEA Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate. IEA GO:0003774 motor activity GSVIVG01035479001 1596631 1632504 GO:0016459 myosin complex A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035479001 1596631 1632504 GO:0016459 myosin complex A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035479001 1596631 1632504 GO:0016459 myosin complex A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01035479001 1596631 1632504 GO:0016459 myosin complex A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. IEA Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits. IEA GO:0051015 actin filament binding GSVIVG01028429001 7447192 7447827 GSVIVG01023658001 8616499 8619634 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01023658001 8616499 8619634 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01023658001 8616499 8619634 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01023658001 8616499 8619634 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023658001 8616499 8619634 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023710001 9794580 9800507 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023710001 9794580 9800507 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01023710001 9794580 9800507 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01023710001 9794580 9800507 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01023710001 9794580 9800507 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023710001 9794580 9800507 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009956001 12787199 12810091 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01036479001 22557040 22557923 GSVIVG01019775001 3205706 3208737 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01019775001 3205706 3208737 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01019775001 3205706 3208737 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01019775001 3205706 3208737 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01019775001 3205706 3208737 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01019775001 3205706 3208737 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01019775001 3205706 3208737 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01019775001 3205706 3208737 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01019775001 3205706 3208737 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01019775001 3205706 3208737 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01019775001 3205706 3208737 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01019775001 3205706 3208737 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01019775001 3205706 3208737 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01019775001 3205706 3208737 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01019775001 3205706 3208737 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01019775001 3205706 3208737 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01019775001 3205706 3208737 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01019775001 3205706 3208737 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01013200001 6802888 6816991 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01013200001 6802888 6816991 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01013200001 6802888 6816991 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01013200001 6802888 6816991 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01013200001 6802888 6816991 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01013200001 6802888 6816991 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01013200001 6802888 6816991 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Combining with prostaglandin E (PGE(2)) to initiate a change in cell activity. IEA GO:0004957 prostaglandin E receptor activity GSVIVG01013200001 6802888 6816991 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Combining with prostaglandin E (PGE(2)) to initiate a change in cell activity. IEA GO:0004957 prostaglandin E receptor activity GSVIVG01013200001 6802888 6816991 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with prostaglandin E (PGE(2)) to initiate a change in cell activity. IEA GO:0004957 prostaglandin E receptor activity GSVIVG01013200001 6802888 6816991 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Combining with prostaglandin E (PGE(2)) to initiate a change in cell activity. IEA GO:0004957 prostaglandin E receptor activity GSVIVG01013200001 6802888 6816991 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Combining with prostaglandin E (PGE(2)) to initiate a change in cell activity. IEA GO:0004957 prostaglandin E receptor activity GSVIVG01013200001 6802888 6816991 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with prostaglandin E (PGE(2)) to initiate a change in cell activity. IEA GO:0004957 prostaglandin E receptor activity GSVIVG01035212001 10608983 10628087 GSVIVG01020147001 9833702 9866988 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01012914001 13360170 13384785 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01001115001 22732853 22736901 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01001115001 22732853 22736901 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01001115001 22732853 22736901 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01001115001 22732853 22736901 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01029255001 17951078 17954009 GO:0006817 phosphate transport The directed movement of phosphate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01029255001 17951078 17954009 GO:0006817 phosphate transport The directed movement of phosphate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a inorganic phosphate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0005315 inorganic phosphate transmembrane transporter activity GSVIVG01029255001 17951078 17954009 GO:0006817 phosphate transport The directed movement of phosphate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029255001 17951078 17954009 GO:0006817 phosphate transport The directed movement of phosphate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of phosphate (PO4 3-) ions from one side of a membrane to the other. IEA GO:0015114 phosphate transmembrane transporter activity GSVIVG01029255001 17951078 17954009 GO:0006817 phosphate transport The directed movement of phosphate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01029255001 17951078 17954009 GO:0006817 phosphate transport The directed movement of phosphate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01014443001 3837563 3838138 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005875 microtubule associated complex Any multimeric complex connected to a microtubule. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01029936001 1739902 1744871 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01011806001 4004382 4010867 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0000808 origin recognition complex A multisubunit complex that is located at the replication origins of a chromosome. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01011806001 4004382 4010867 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01011806001 4004382 4010867 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0000808 origin recognition complex A multisubunit complex that is located at the replication origins of a chromosome. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01011806001 4004382 4010867 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01011806001 4004382 4010867 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0000808 origin recognition complex A multisubunit complex that is located at the replication origins of a chromosome. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01011806001 4004382 4010867 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01011806001 4004382 4010867 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0000808 origin recognition complex A multisubunit complex that is located at the replication origins of a chromosome. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01011806001 4004382 4010867 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01011806001 4004382 4010867 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0000808 origin recognition complex A multisubunit complex that is located at the replication origins of a chromosome. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011806001 4004382 4010867 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011806001 4004382 4010867 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0000808 origin recognition complex A multisubunit complex that is located at the replication origins of a chromosome. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011806001 4004382 4010867 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011806001 4004382 4010867 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0000808 origin recognition complex A multisubunit complex that is located at the replication origins of a chromosome. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01011806001 4004382 4010867 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01011806001 4004382 4010867 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0000808 origin recognition complex A multisubunit complex that is located at the replication origins of a chromosome. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01011806001 4004382 4010867 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01037770001 7716741 7719369 GSVIVG01031419001 18799985 18808243 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: phosphatidylcholine + a sterol = a sterol ester + 1-acylglycerophosphocholine. IEA GO:0004607 phosphatidylcholine-sterol O-acyltransferase activity GSVIVG01031419001 18799985 18808243 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01023047001 16413405 16414604 GSVIVG01008587001 604662 637273 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032641001 1912651 1927031 GO:0032313 regulation of Rab GTPase activity Any process that modulates the activity of a GTPase of the Rab family. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Increases the rate of GTP hydrolysis by a GTPase of the Rab family. IEA GO:0005097 Rab GTPase activator activity GSVIVG01029034001 11007058 11011480 GSVIVG01000540001 7270256 7277242 GSVIVG01022415001 19902054 19905869 GSVIVG01010375001 19942746 19949762 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0005839 proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. IEA GO:0004175 endopeptidase activity GSVIVG01010375001 19942746 19949762 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0005839 proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. IEA Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. IEA GO:0004298 threonine-type endopeptidase activity GSVIVG01035833001 4744789 4749649 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01035833001 4744789 4749649 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01035833001 4744789 4749649 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01035833001 4744789 4749649 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01035833001 4744789 4749649 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01035833001 4744789 4749649 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01035833001 4744789 4749649 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01035833001 4744789 4749649 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01035833001 4744789 4749649 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01035833001 4744789 4749649 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035833001 4744789 4749649 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035833001 4744789 4749649 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035833001 4744789 4749649 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035833001 4744789 4749649 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035833001 4744789 4749649 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035833001 4744789 4749649 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035833001 4744789 4749649 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035833001 4744789 4749649 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024823001 6601947 6615570 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01024823001 6601947 6615570 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01030913001 18900810 18905410 GSVIVG01023852001 2970316 2972915 GO:0008299 isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+. IEA GO:0004420 hydroxymethylglutaryl-CoA reductase (NADPH) activity GSVIVG01023852001 2970316 2972915 GO:0015936 coenzyme A metabolic process The chemical reactions and pathways involving coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+. IEA GO:0004420 hydroxymethylglutaryl-CoA reductase (NADPH) activity GSVIVG01023852001 2970316 2972915 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+. IEA GO:0004420 hydroxymethylglutaryl-CoA reductase (NADPH) activity GSVIVG01023852001 2970316 2972915 GO:0008299 isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01023852001 2970316 2972915 GO:0015936 coenzyme A metabolic process The chemical reactions and pathways involving coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01023852001 2970316 2972915 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01023852001 2970316 2972915 GO:0008299 isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01023852001 2970316 2972915 GO:0015936 coenzyme A metabolic process The chemical reactions and pathways involving coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01023852001 2970316 2972915 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01023852001 2970316 2972915 GO:0008299 isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01023852001 2970316 2972915 GO:0015936 coenzyme A metabolic process The chemical reactions and pathways involving coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01023852001 2970316 2972915 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01035226001 10818526 10828335 GSVIVG01021314001 3915070 3919935 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01021314001 3915070 3919935 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01021314001 3915070 3919935 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01021314001 3915070 3919935 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01014916001 11829100 11829309 GSVIVG01012698001 798505 800805 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01012698001 798505 800805 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01012698001 798505 800805 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015855001 18452318 18460134 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015855001 18452318 18460134 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nucleotidyl group to a reactant. IEA GO:0016779 nucleotidyltransferase activity GSVIVG01003677001 12037857 12042284 GSVIVG01030726001 14603634 14604173 GSVIVG01020315001 21479384 21480445 GSVIVG01038745001 356137 368691 GO:0007585 respiratory gaseous exchange The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. IEA GO:0005740 mitochondrial envelope The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01038745001 356137 368691 GO:0007585 respiratory gaseous exchange The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01038745001 356137 368691 GO:0007585 respiratory gaseous exchange The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01038745001 356137 368691 GO:0007585 respiratory gaseous exchange The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. IEA GO:0070469 respiratory chain The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01038745001 356137 368691 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0005740 mitochondrial envelope The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01038745001 356137 368691 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01038745001 356137 368691 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01038745001 356137 368691 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0070469 respiratory chain The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01038745001 356137 368691 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005740 mitochondrial envelope The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01038745001 356137 368691 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01038745001 356137 368691 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01038745001 356137 368691 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0070469 respiratory chain The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01038745001 356137 368691 GO:0007585 respiratory gaseous exchange The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. IEA GO:0005740 mitochondrial envelope The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01038745001 356137 368691 GO:0007585 respiratory gaseous exchange The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01038745001 356137 368691 GO:0007585 respiratory gaseous exchange The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01038745001 356137 368691 GO:0007585 respiratory gaseous exchange The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. IEA GO:0070469 respiratory chain The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01038745001 356137 368691 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0005740 mitochondrial envelope The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01038745001 356137 368691 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01038745001 356137 368691 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01038745001 356137 368691 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0070469 respiratory chain The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01038745001 356137 368691 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005740 mitochondrial envelope The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01038745001 356137 368691 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01038745001 356137 368691 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01038745001 356137 368691 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0070469 respiratory chain The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01038745001 356137 368691 GO:0007585 respiratory gaseous exchange The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. IEA GO:0005740 mitochondrial envelope The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01038745001 356137 368691 GO:0007585 respiratory gaseous exchange The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01038745001 356137 368691 GO:0007585 respiratory gaseous exchange The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01038745001 356137 368691 GO:0007585 respiratory gaseous exchange The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. IEA GO:0070469 respiratory chain The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01038745001 356137 368691 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0005740 mitochondrial envelope The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01038745001 356137 368691 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01038745001 356137 368691 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01038745001 356137 368691 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0070469 respiratory chain The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01038745001 356137 368691 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005740 mitochondrial envelope The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01038745001 356137 368691 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01038745001 356137 368691 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01038745001 356137 368691 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0070469 respiratory chain The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01019343001 766152 766325 GSVIVG01027847001 8594494 8604824 GO:0046836 glycolipid transport The directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Enables the directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of, within or between cells. IEA GO:0017089 glycolipid transporter activity GSVIVG01027847001 8594494 8604824 GO:0046836 glycolipid transport The directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a glycolipid, any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic moiety such as an acylglycerol, a sphingoid, a ceramide (N-acylsphingoid) or a prenyl phosphate. IEA GO:0051861 glycolipid binding GSVIVG01007445001 31983327 31983793 GSVIVG01035729001 3752655 3757587 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01035729001 3752655 3757587 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01035729001 3752655 3757587 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01035729001 3752655 3757587 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion. IEA GO:0005484 SNAP receptor activity GSVIVG01035729001 3752655 3757587 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion. IEA GO:0005484 SNAP receptor activity GSVIVG01035729001 3752655 3757587 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion. IEA GO:0005484 SNAP receptor activity GSVIVG01035729001 3752655 3757587 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035729001 3752655 3757587 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035729001 3752655 3757587 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031744001 4000150 4010034 GSVIVG01001078001 22414829 22417602 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01001078001 22414829 22417602 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01001078001 22414829 22417602 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01001078001 22414829 22417602 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024064001 1405936 1408542 Catalysis of the transfer of the amide nitrogen of glutamine to a variety of substrates. GATases catalyze two separate reactions at two active sites, which are located either on a single polypeptide chain or on different subunits. In the glutaminase reaction, glutamine is hydrolyzed to glutamate and ammonia, which is added to an acceptor substrate in the synthase reaction. IEA GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor GSVIVG01000583001 6863499 6866630 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01000583001 6863499 6866630 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01023696001 9438447 9445652 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01018009001 5440366 5440722 GO:0006869 lipid transport The directed movement of lipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Interacting selectively and non-covalently with a lipid. IEA GO:0008289 lipid binding GSVIVG01028792001 18748878 18753944 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01028792001 18748878 18753944 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028792001 18748878 18753944 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01010744001 22067897 22069201 GSVIVG01035581001 2492836 2493622 GSVIVG01035048001 1163455 1164868 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01035048001 1163455 1164868 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01035048001 1163455 1164868 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01033661001 18843473 18845659 GSVIVG01019855001 3857081 3867232 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function that links a sequence-specific transcription factor to the core RNA polymerase II complex but does not bind DNA itself. IEA GO:0003712 transcription cofactor activity GSVIVG01030869001 18041230 18102326 GO:0008615 pyridoxine biosynthetic process The chemical reactions and pathways resulting in the formation of pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, one of the vitamin B6 compounds. IEA Catalysis of the reaction: ATP + pyridoxal = ADP + pyridoxal 5'-phosphate. IEA GO:0008478 pyridoxal kinase activity GSVIVG01006403001 25650919 25653446 GO:0009416 response to light stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01006403001 25650919 25653446 GO:0009416 response to light stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020118001 10175845 10178979 GSVIVG01017782001 3443511 3447078 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017782001 3443511 3447078 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01026626001 20912726 20914980 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01026626001 20912726 20914980 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01026626001 20912726 20914980 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01026626001 20912726 20914980 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024690001 7687225 7690630 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01025656001 13239569 13251238 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion. IEA GO:0005484 SNAP receptor activity GSVIVG01001912001 7137228 7146962 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin. IEA GO:0004221 ubiquitin thiolesterase activity GSVIVG01009757001 11019357 11020304 GSVIVG01034573001 19223278 19225297 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01034573001 19223278 19225297 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01034573001 19223278 19225297 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01034573001 19223278 19225297 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006089001 41314895 41315789 GSVIVG01000101001 3538018 3538905 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with manganese (Mn) ions. IEA GO:0030145 manganese ion binding GSVIVG01000101001 3538018 3538905 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Functions in the storage of nutritious substrates. IEA GO:0045735 nutrient reservoir activity GSVIVG01029349001 14981193 14986226 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GSVIVG01009023001 4350466 4352639 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01009023001 4350466 4352639 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01009023001 4350466 4352639 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01009023001 4350466 4352639 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01009023001 4350466 4352639 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01009023001 4350466 4352639 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01036450001 22166810 22173012 GSVIVG01033068001 25537664 25538539 GSVIVG01028746001 19207202 19213829 GSVIVG01028454001 7818245 7818791 GSVIVG01024427001 2453269 2456083 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023034001 16578053 16582736 GSVIVG01024680001 7804413 7816024 GO:0006464 protein modification process The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024680001 7804413 7816024 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024680001 7804413 7816024 GO:0006464 protein modification process The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024680001 7804413 7816024 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024680001 7804413 7816024 GO:0006464 protein modification process The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024680001 7804413 7816024 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024680001 7804413 7816024 GO:0006464 protein modification process The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). IEA Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond. IEA GO:0008641 small protein activating enzyme activity GSVIVG01024680001 7804413 7816024 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond. IEA GO:0008641 small protein activating enzyme activity GSVIVG01001597001 18233328 18233812 GSVIVG01004445001 38606407 38609245 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01023665001 8714231 8718592 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01023665001 8714231 8718592 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01023665001 8714231 8718592 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01023665001 8714231 8718592 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023665001 8714231 8718592 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015336001 2778391 2781201 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01015336001 2778391 2781201 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01002654001 35691176 35694634 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01034062001 15473061 15474218 GSVIVG01032364001 26738301 26739656 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01038673001 21082369 21083213 GSVIVG01032569001 28457051 28465146 Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity. IEA GO:0004721 phosphoprotein phosphatase activity GSVIVG01032569001 28457051 28465146 Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01032569001 28457051 28465146 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01009622001 9950574 9959545 GSVIVG01008674001 1111708 1129725 GSVIVG01016078001 18486077 18496179 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01014919001 11890843 11891021 GSVIVG01026810001 7612556 7643310 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01026810001 7612556 7643310 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01026810001 7612556 7643310 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01026810001 7612556 7643310 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01020985001 15921763 15922767 GSVIVG01008256001 4009899 4011992 GSVIVG01021951001 5204116 5206996 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01021951001 5204116 5206996 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01021951001 5204116 5206996 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01021951001 5204116 5206996 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01021951001 5204116 5206996 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021951001 5204116 5206996 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008823001 2479870 2485400 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01020945001 16683695 16689259 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01001122001 22798594 22814521 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01001122001 22798594 22814521 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01001122001 22798594 22814521 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01001122001 22798594 22814521 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01001122001 22798594 22814521 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01001122001 22798594 22814521 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01001122001 22798594 22814521 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01001122001 22798594 22814521 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01001122001 22798594 22814521 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01001122001 22798594 22814521 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01001122001 22798594 22814521 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01001122001 22798594 22814521 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01001122001 22798594 22814521 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01001122001 22798594 22814521 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01001122001 22798594 22814521 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01001122001 22798594 22814521 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01001122001 22798594 22814521 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01001122001 22798594 22814521 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01001122001 22798594 22814521 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01001122001 22798594 22814521 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01001122001 22798594 22814521 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001122001 22798594 22814521 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001122001 22798594 22814521 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001122001 22798594 22814521 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001122001 22798594 22814521 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01001122001 22798594 22814521 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01001122001 22798594 22814521 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01001122001 22798594 22814521 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01001122001 22798594 22814521 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces an oxygen molecule. IEA GO:0050664 oxidoreductase activity, acting on NADH or NADPH, with oxygen as acceptor GSVIVG01001122001 22798594 22814521 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces an oxygen molecule. IEA GO:0050664 oxidoreductase activity, acting on NADH or NADPH, with oxygen as acceptor GSVIVG01001122001 22798594 22814521 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces an oxygen molecule. IEA GO:0050664 oxidoreductase activity, acting on NADH or NADPH, with oxygen as acceptor GSVIVG01001122001 22798594 22814521 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces an oxygen molecule. IEA GO:0050664 oxidoreductase activity, acting on NADH or NADPH, with oxygen as acceptor GSVIVG01034985001 686536 688008 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the reaction: pectin + n H2O = n methanol + pectate. IEA GO:0030599 pectinesterase activity GSVIVG01021436001 5324005 5344766 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01021436001 5324005 5344766 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01021436001 5324005 5344766 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01021436001 5324005 5344766 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01021436001 5324005 5344766 GO:0009252 peptidoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01021436001 5324005 5344766 GO:0009252 peptidoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01021436001 5324005 5344766 GO:0009252 peptidoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01021436001 5324005 5344766 GO:0009252 peptidoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01021436001 5324005 5344766 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + undecaprenyl phosphate = UMP + N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine-diphosphoundecaprenol. IEA GO:0008963 phospho-N-acetylmuramoyl-pentapeptide-transferase activity GSVIVG01021436001 5324005 5344766 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + undecaprenyl phosphate = UMP + N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine-diphosphoundecaprenol. IEA GO:0008963 phospho-N-acetylmuramoyl-pentapeptide-transferase activity GSVIVG01021436001 5324005 5344766 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + undecaprenyl phosphate = UMP + N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine-diphosphoundecaprenol. IEA GO:0008963 phospho-N-acetylmuramoyl-pentapeptide-transferase activity GSVIVG01021436001 5324005 5344766 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + undecaprenyl phosphate = UMP + N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine-diphosphoundecaprenol. IEA GO:0008963 phospho-N-acetylmuramoyl-pentapeptide-transferase activity GSVIVG01021436001 5324005 5344766 GO:0009252 peptidoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + undecaprenyl phosphate = UMP + N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine-diphosphoundecaprenol. IEA GO:0008963 phospho-N-acetylmuramoyl-pentapeptide-transferase activity GSVIVG01021436001 5324005 5344766 GO:0009252 peptidoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + undecaprenyl phosphate = UMP + N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine-diphosphoundecaprenol. IEA GO:0008963 phospho-N-acetylmuramoyl-pentapeptide-transferase activity GSVIVG01021436001 5324005 5344766 GO:0009252 peptidoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + undecaprenyl phosphate = UMP + N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine-diphosphoundecaprenol. IEA GO:0008963 phospho-N-acetylmuramoyl-pentapeptide-transferase activity GSVIVG01021436001 5324005 5344766 GO:0009252 peptidoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + undecaprenyl phosphate = UMP + N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine-diphosphoundecaprenol. IEA GO:0008963 phospho-N-acetylmuramoyl-pentapeptide-transferase activity GSVIVG01035243001 11208512 11211508 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01031522001 17701130 17702519 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01031522001 17701130 17702519 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01017084001 4061965 4064269 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01017084001 4061965 4064269 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01017084001 4061965 4064269 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01017084001 4061965 4064269 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01028926001 17447152 17448333 GSVIVG01016690001 381368 383394 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01003779001 12560879 12561137 GSVIVG01038230001 24507462 24509204 GO:0009308 amine metabolic process The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01038230001 24507462 24509204 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01038230001 24507462 24509204 GO:0009308 amine metabolic process The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. IEA Catalysis of the reaction: R-CH2-NH2 + H2O + O2 = R-CHO + NH3 + H2O2. IEA GO:0008131 amine oxidase activity GSVIVG01038230001 24507462 24509204 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: R-CH2-NH2 + H2O + O2 = R-CHO + NH3 + H2O2. IEA GO:0008131 amine oxidase activity GSVIVG01038230001 24507462 24509204 GO:0009308 amine metabolic process The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. IEA Interacting selectively and non-covalently with a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds. IEA GO:0048038 quinone binding GSVIVG01038230001 24507462 24509204 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds. IEA GO:0048038 quinone binding GSVIVG01019535001 1420763 1423272 GSVIVG01036090001 20794573 20795984 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035096001 1454421 1457901 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035096001 1454421 1457901 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035096001 1454421 1457901 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035096001 1454421 1457901 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035096001 1454421 1457901 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035096001 1454421 1457901 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035096001 1454421 1457901 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01035096001 1454421 1457901 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01035096001 1454421 1457901 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01035096001 1454421 1457901 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01035096001 1454421 1457901 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01035096001 1454421 1457901 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01032774001 861550 868902 GSVIVG01016257001 5881321 5885139 GO:0006559 L-phenylalanine catabolic process The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016257001 5881321 5885139 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016257001 5881321 5885139 GO:0006559 L-phenylalanine catabolic process The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of ammonia (NH3) to another substance via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. IEA GO:0016211 ammonia ligase activity GSVIVG01016257001 5881321 5885139 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of ammonia (NH3) to another substance via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. IEA GO:0016211 ammonia ligase activity GSVIVG01016257001 5881321 5885139 GO:0006559 L-phenylalanine catabolic process The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate. IEA GO:0016841 ammonia-lyase activity GSVIVG01016257001 5881321 5885139 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate. IEA GO:0016841 ammonia-lyase activity GSVIVG01008628001 299665 302297 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01015349001 2875445 2879847 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01015349001 2875445 2879847 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01005061001 17810136 17811409 GSVIVG01013922001 6844103 6844791 GSVIVG01033984001 16109450 16111349 GSVIVG01024632001 8234961 8244912 GSVIVG01020815001 1637783 1644297 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01011090001 1678555 1683068 GSVIVG01027170001 17284082 17286056 GSVIVG01029081001 12124246 12124599 GSVIVG01038201001 24301234 24306993 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01038201001 24301234 24306993 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01002717001 36049422 36053526 GSVIVG01006264001 24302067 24322860 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01006264001 24302067 24322860 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01006264001 24302067 24322860 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. IEA GO:0004563 beta-N-acetylhexosaminidase activity GSVIVG01006264001 24302067 24322860 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01016034001 17678057 17679690 Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01016034001 17678057 17679690 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016034001 17678057 17679690 Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01025232001 2948720 2968436 GSVIVG01017316001 6678926 6683654 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035603001 2635806 2635892 GSVIVG01018283001 11991331 11992413 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion. IEA GO:0004806 triglyceride lipase activity GSVIVG01018259001 12349184 12349849 GSVIVG01024146001 799108 799188 GSVIVG01001004001 11317262 11335182 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. IEA GO:0016597 amino acid binding GSVIVG01001816001 26043592 26051428 GO:0006779 porphyrin biosynthetic process The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001816001 26043592 26051428 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001816001 26043592 26051428 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001816001 26043592 26051428 GO:0006779 porphyrin biosynthetic process The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group. IEA Catalysis of the reaction: protoporphyrinogen-IX + O2 = protoporphyrin-IX + H2O2. IEA GO:0004729 oxygen-dependent protoporphyrinogen oxidase activity GSVIVG01001816001 26043592 26051428 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: protoporphyrinogen-IX + O2 = protoporphyrin-IX + H2O2. IEA GO:0004729 oxygen-dependent protoporphyrinogen oxidase activity GSVIVG01001816001 26043592 26051428 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: protoporphyrinogen-IX + O2 = protoporphyrin-IX + H2O2. IEA GO:0004729 oxygen-dependent protoporphyrinogen oxidase activity GSVIVG01001816001 26043592 26051428 GO:0006779 porphyrin biosynthetic process The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01001816001 26043592 26051428 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01001816001 26043592 26051428 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01036934001 17393637 17408885 GSVIVG01029549001 21696763 21699261 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01029549001 21696763 21699261 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01038604001 21549119 21553502 GSVIVG01018464001 14705029 14709730 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01018464001 14705029 14709730 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018464001 14705029 14709730 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity. IEA GO:0004721 phosphoprotein phosphatase activity GSVIVG01018464001 14705029 14709730 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. IEA GO:0004722 protein serine/threonine phosphatase activity GSVIVG01018464001 14705029 14709730 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01018464001 14705029 14709730 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01012944001 14092768 14094314 GSVIVG01032193001 21693970 21696840 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01032193001 21693970 21696840 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01032193001 21693970 21696840 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01032193001 21693970 21696840 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01032193001 21693970 21696840 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA A sigma factor is the promoter specificity subunit of eubacterial-type multisubunit RNA polymerases, those whose core subunit composition is often described as alpha(2)-beta-beta-prime. (This type of multisubunit RNA polymerase complex is known to be found in eubacteria and plant plastids). Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, this binds specifically to promoter sequences, with the sigma factor making sequence specific contacts with the promoter elements. The sigma subunit is released from the elongating form of the polymerase and is thus free to act catalytically for multiple RNA polymerase core enzymes. IEA GO:0016987 sigma factor activity GSVIVG01032193001 21693970 21696840 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA A sigma factor is the promoter specificity subunit of eubacterial-type multisubunit RNA polymerases, those whose core subunit composition is often described as alpha(2)-beta-beta-prime. (This type of multisubunit RNA polymerase complex is known to be found in eubacteria and plant plastids). Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, this binds specifically to promoter sequences, with the sigma factor making sequence specific contacts with the promoter elements. The sigma subunit is released from the elongating form of the polymerase and is thus free to act catalytically for multiple RNA polymerase core enzymes. IEA GO:0016987 sigma factor activity GSVIVG01014154001 897658 902185 GSVIVG01003889001 13209976 13210382 GSVIVG01033793001 17783407 17784006 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01033793001 17783407 17784006 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01033793001 17783407 17784006 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01033793001 17783407 17784006 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01033793001 17783407 17784006 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01033793001 17783407 17784006 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01030154001 10459374 10459628 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01030154001 10459374 10459628 GO:0006423 cysteinyl-tRNA aminoacylation The process of coupling cysteine to cysteinyl-tRNA, catalyzed by cysteinyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01030154001 10459374 10459628 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys). IEA GO:0004817 cysteine-tRNA ligase activity GSVIVG01030154001 10459374 10459628 GO:0006423 cysteinyl-tRNA aminoacylation The process of coupling cysteine to cysteinyl-tRNA, catalyzed by cysteinyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys). IEA GO:0004817 cysteine-tRNA ligase activity GSVIVG01030154001 10459374 10459628 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030154001 10459374 10459628 GO:0006423 cysteinyl-tRNA aminoacylation The process of coupling cysteine to cysteinyl-tRNA, catalyzed by cysteinyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025581001 13906822 13909138 GSVIVG01030666001 13171184 13173463 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030666001 13171184 13173463 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01030666001 13171184 13173463 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01019162001 15826162 15887813 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01019162001 15826162 15887813 GO:0030259 lipid glycosylation Covalent attachment of a glycosyl residue to a lipid molecule. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01015782001 17434757 17439101 GSVIVG01001035001 6707823 6733177 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Catalysis of the reaction: ATP + AMP = 2 ADP. IEA GO:0004017 adenylate kinase activity GSVIVG01001035001 6707823 6733177 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001035001 6707823 6733177 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a phosphate group (acceptor). IEA GO:0016776 phosphotransferase activity, phosphate group as acceptor GSVIVG01001035001 6707823 6733177 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Catalysis of the reaction: ATP + nucleoside monophosphate = ADP + nucleoside diphosphate. IEA GO:0019201 nucleotide kinase activity GSVIVG01001035001 6707823 6733177 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate. IEA GO:0019205 nucleobase, nucleoside, nucleotide kinase activity GSVIVG01024465001 2965145 2984101 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01024465001 2965145 2984101 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01024465001 2965145 2984101 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end. IEA GO:0004527 exonuclease activity GSVIVG01024465001 2965145 2984101 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end. IEA GO:0004527 exonuclease activity GSVIVG01024465001 2965145 2984101 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of an RNA molecule. IEA GO:0004534 5'-3' exoribonuclease activity GSVIVG01024465001 2965145 2984101 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of an RNA molecule. IEA GO:0004534 5'-3' exoribonuclease activity GSVIVG01014153001 884762 893703 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01032585001 28581938 28584123 GSVIVG01017729001 2972087 2979785 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01031439001 18563263 18569132 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0008236 serine-type peptidase activity GSVIVG01021756001 10644348 10647174 GSVIVG01011745001 4638278 4649298 GSVIVG01036365001 4245637 4245919 GSVIVG01009513001 8971690 8972434 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01009513001 8971690 8972434 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01009513001 8971690 8972434 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01009513001 8971690 8972434 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01009513001 8971690 8972434 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009513001 8971690 8972434 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032968001 24673432 24675024 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032968001 24673432 24675024 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032968001 24673432 24675024 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032968001 24673432 24675024 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01032968001 24673432 24675024 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01032968001 24673432 24675024 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01032968001 24673432 24675024 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01032968001 24673432 24675024 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01032968001 24673432 24675024 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01032968001 24673432 24675024 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01032968001 24673432 24675024 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01032968001 24673432 24675024 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01025969001 26469275 26471226 GSVIVG01006374001 25343115 25345547 GSVIVG01031479001 18120004 18130396 GSVIVG01011757001 4447384 4454698 GSVIVG01038098001 23484128 23488627 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038098001 23484128 23488627 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038098001 23484128 23488627 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01038098001 23484128 23488627 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01030461001 5774133 5789113 GSVIVG01006761001 28234026 28238002 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01006761001 28234026 28238002 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01006761001 28234026 28238002 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01006761001 28234026 28238002 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01030888001 18422640 18433220 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01030888001 18422640 18433220 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01030888001 18422640 18433220 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01030888001 18422640 18433220 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01030888001 18422640 18433220 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01030888001 18422640 18433220 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01030888001 18422640 18433220 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030888001 18422640 18433220 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030888001 18422640 18433220 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030888001 18422640 18433220 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01030888001 18422640 18433220 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01030888001 18422640 18433220 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01027703001 14103013 14103842 GSVIVG01033349001 21311999 21315741 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01032824001 473988 480801 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01032824001 473988 480801 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01032824001 473988 480801 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032824001 473988 480801 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032824001 473988 480801 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01032824001 473988 480801 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01032018001 23484013 23509637 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032018001 23484013 23509637 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032018001 23484013 23509637 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01032018001 23484013 23509637 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01032018001 23484013 23509637 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01032018001 23484013 23509637 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01032018001 23484013 23509637 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01032018001 23484013 23509637 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01032018001 23484013 23509637 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01032018001 23484013 23509637 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01011754001 4488301 4491290 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01011754001 4488301 4491290 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01011754001 4488301 4491290 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01011754001 4488301 4491290 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01011754001 4488301 4491290 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01011754001 4488301 4491290 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01011754001 4488301 4491290 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01011754001 4488301 4491290 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01011754001 4488301 4491290 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01011754001 4488301 4491290 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01011754001 4488301 4491290 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01011754001 4488301 4491290 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01003662001 11882171 11883704 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01003219001 14039774 14044487 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01038614001 21461671 21468729 GO:0032313 regulation of Rab GTPase activity Any process that modulates the activity of a GTPase of the Rab family. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Increases the rate of GTP hydrolysis by a GTPase of the Rab family. IEA GO:0005097 Rab GTPase activator activity GSVIVG01017878001 4233886 4240321 GO:0009186 deoxyribonucleoside diphosphate metabolic process The chemical reactions and pathways involving a deoxyribonucleoside diphosphate, a glycosamine consisting of a base linked to a deoxyribose sugar esterified with diphosphate on its glycose moiety. IEA Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin. IEA GO:0004748 ribonucleoside-diphosphate reductase activity GSVIVG01017878001 4233886 4240321 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin. IEA GO:0004748 ribonucleoside-diphosphate reductase activity GSVIVG01017878001 4233886 4240321 GO:0009186 deoxyribonucleoside diphosphate metabolic process The chemical reactions and pathways involving a deoxyribonucleoside diphosphate, a glycosamine consisting of a base linked to a deoxyribose sugar esterified with diphosphate on its glycose moiety. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01017878001 4233886 4240321 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01017878001 4233886 4240321 GO:0009186 deoxyribonucleoside diphosphate metabolic process The chemical reactions and pathways involving a deoxyribonucleoside diphosphate, a glycosamine consisting of a base linked to a deoxyribose sugar esterified with diphosphate on its glycose moiety. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01017878001 4233886 4240321 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01022189001 17301571 17310158 GSVIVG01026072001 24941768 24953370 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01026072001 24941768 24953370 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01026072001 24941768 24953370 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01026072001 24941768 24953370 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01026072001 24941768 24953370 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01026072001 24941768 24953370 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01026072001 24941768 24953370 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01026072001 24941768 24953370 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01026072001 24941768 24953370 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01026072001 24941768 24953370 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01026072001 24941768 24953370 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01026072001 24941768 24953370 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01030698001 13747887 13748015 GSVIVG01009323001 7438730 7439704 GSVIVG01009648001 10192997 10194992 GSVIVG01001112001 22706570 22709016 GSVIVG01020711001 2887249 2889903 GSVIVG01019635001 2111570 2121699 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01017877001 4226908 4231360 GSVIVG01020988001 15889272 15890243 GSVIVG01034983001 672867 674782 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01034983001 672867 674782 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01034983001 672867 674782 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01034983001 672867 674782 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01034983001 672867 674782 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01034983001 672867 674782 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01034983001 672867 674782 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01034983001 672867 674782 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01034983001 672867 674782 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01034983001 672867 674782 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01034983001 672867 674782 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01034983001 672867 674782 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01034983001 672867 674782 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01034983001 672867 674782 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01034983001 672867 674782 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01034983001 672867 674782 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01034983001 672867 674782 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01034983001 672867 674782 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01034983001 672867 674782 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01034983001 672867 674782 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01034983001 672867 674782 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01018787001 19837737 19839174 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01018787001 19837737 19839174 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01018787001 19837737 19839174 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01018787001 19837737 19839174 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01018787001 19837737 19839174 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01018787001 19837737 19839174 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01012615001 36174 37778 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019377001 124040 125348 GO:0009765 photosynthesis, light harvesting Absorption and transfer of the energy absorbed from light photons between photosystem reaction centers. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01005227001 19519739 19526528 GSVIVG01030590001 6955245 6971859 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01030590001 6955245 6971859 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01030590001 6955245 6971859 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01030590001 6955245 6971859 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01016502001 3340692 3342959 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01016502001 3340692 3342959 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01016502001 3340692 3342959 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01016502001 3340692 3342959 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016502001 3340692 3342959 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009011001 4264864 4269301 GSVIVG01032250001 13879697 13975136 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032250001 13879697 13975136 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032250001 13879697 13975136 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01032250001 13879697 13975136 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01032250001 13879697 13975136 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01032250001 13879697 13975136 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01024476001 3098953 3099984 GSVIVG01018810001 19667490 19672853 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GSVIVG01018810001 19667490 19672853 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GSVIVG01013557001 20813451 20843565 GSVIVG01011586001 6226980 6230660 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01011586001 6226980 6230660 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01011586001 6226980 6230660 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01011586001 6226980 6230660 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01011586001 6226980 6230660 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001389001 24148238 24156464 GSVIVG01022335001 18579336 18580855 GSVIVG01016455001 3740286 3750179 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01016455001 3740286 3750179 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01016455001 3740286 3750179 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01016455001 3740286 3750179 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01034719001 8342804 8347044 Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01034719001 8342804 8347044 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01024785001 6961440 6966541 GSVIVG01019267001 2313527 2316141 GSVIVG01020883001 17754748 17755204 GSVIVG01004712001 15424648 15426453 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032528001 28107504 28112390 The action of a molecule that contributes to the structural integrity of a cell wall. IEA GO:0005199 structural constituent of cell wall GSVIVG01022832001 18962251 18970140 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01022720001 15557683 15558743 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. IEA GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GSVIVG01021388001 4786396 4806676 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01021388001 4786396 4806676 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0008236 serine-type peptidase activity GSVIVG01002063001 1278819 1288057 GSVIVG01035852001 4888330 4892373 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035852001 4888330 4892373 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01029659001 12622007 12622474 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01017582001 10965963 10970974 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01017582001 10965963 10970974 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01017582001 10965963 10970974 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01017582001 10965963 10970974 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01031655001 19637029 19638486 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin. IEA GO:0004221 ubiquitin thiolesterase activity GSVIVG01013832001 5021888 5023523 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the reaction: pectin + n H2O = n methanol + pectate. IEA GO:0030599 pectinesterase activity GSVIVG01000961001 22304970 22308253 GSVIVG01017554001 10500603 10501421 GSVIVG01009779001 11196526 11198339 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01009779001 11196526 11198339 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01009779001 11196526 11198339 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01009779001 11196526 11198339 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01009779001 11196526 11198339 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01009779001 11196526 11198339 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01029927001 1571972 1580783 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01029927001 1571972 1580783 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01029927001 1571972 1580783 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01029927001 1571972 1580783 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01029927001 1571972 1580783 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01029927001 1571972 1580783 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01029927001 1571972 1580783 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01029927001 1571972 1580783 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01029927001 1571972 1580783 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01024987001 5470020 5473553 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020354001 20810625 20819467 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01020354001 20810625 20819467 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01020996001 15682246 15683832 GSVIVG01015249001 2100745 2104510 GSVIVG01007855001 8334542 8340204 GSVIVG01020018001 11514872 11528515 Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers. IEA GO:0008017 microtubule binding GSVIVG01018832001 19492612 19494687 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01018832001 19492612 19494687 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01018832001 19492612 19494687 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01018832001 19492612 19494687 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01015851001 18402495 18403698 GSVIVG01010319001 19418612 19452763 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01020670001 3217889 3224713 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01020670001 3217889 3224713 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01014736001 9077802 9082842 GSVIVG01014862001 10747971 10749212 GSVIVG01017664001 2461819 2479636 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017664001 2461819 2479636 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01033439001 20680492 20683558 GSVIVG01024032001 1639344 1639821 GSVIVG01011397001 29333101 29335862 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01011397001 29333101 29335862 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01011397001 29333101 29335862 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01011397001 29333101 29335862 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01011397001 29333101 29335862 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01011397001 29333101 29335862 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01011397001 29333101 29335862 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01011397001 29333101 29335862 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01011397001 29333101 29335862 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011397001 29333101 29335862 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011397001 29333101 29335862 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01011397001 29333101 29335862 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01011397001 29333101 29335862 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01011397001 29333101 29335862 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01011397001 29333101 29335862 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01011397001 29333101 29335862 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01032491001 27846210 27848937 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01032491001 27846210 27848937 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01032491001 27846210 27848937 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01032491001 27846210 27848937 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01032491001 27846210 27848937 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The action of a molecule that contributes to the structural integrity of a cytoskeletal structure. IEA GO:0005200 structural constituent of cytoskeleton GSVIVG01032491001 27846210 27848937 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The action of a molecule that contributes to the structural integrity of a cytoskeletal structure. IEA GO:0005200 structural constituent of cytoskeleton GSVIVG01032491001 27846210 27848937 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01032491001 27846210 27848937 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01032491001 27846210 27848937 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01032491001 27846210 27848937 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01007775001 9166428 9172256 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01007775001 9166428 9172256 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01007775001 9166428 9172256 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01007775001 9166428 9172256 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007973001 7056646 7057026 GSVIVG01019761001 3074405 3119122 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01019761001 3074405 3119122 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01003567001 14716030 14718994 GSVIVG01005599001 40810117 40812345 GSVIVG01014993001 145352 225435 GO:0032012 regulation of ARF protein signal transduction Any process that modulates the frequency, rate or extent of ARF protein signal transduction. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Stimulates the exchange of guanyl nucleotides associated with the GTPase ARF. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. IEA GO:0005086 ARF guanyl-nucleotide exchange factor activity GSVIVG01014993001 145352 225435 GO:0032012 regulation of ARF protein signal transduction Any process that modulates the frequency, rate or extent of ARF protein signal transduction. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01014219001 1594074 1612711 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014219001 1594074 1612711 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. IEA GO:0008080 N-acetyltransferase activity GSVIVG01014219001 1594074 1612711 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01035440001 1280894 1283643 GSVIVG01025785001 11896594 11898119 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01008641001 191903 199918 GSVIVG01001679001 14207946 14210222 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01001679001 14207946 14210222 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01001679001 14207946 14210222 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01001679001 14207946 14210222 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001679001 14207946 14210222 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01004101001 14810245 14815280 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01004101001 14810245 14815280 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01004101001 14810245 14815280 GO:0042773 ATP synthesis coupled electron transport The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01004101001 14810245 14815280 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01004101001 14810245 14815280 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01004101001 14810245 14815280 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01004101001 14810245 14815280 GO:0042773 ATP synthesis coupled electron transport The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01004101001 14810245 14815280 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01004101001 14810245 14815280 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. IEA GO:0008137 NADH dehydrogenase (ubiquinone) activity GSVIVG01004101001 14810245 14815280 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. IEA GO:0008137 NADH dehydrogenase (ubiquinone) activity GSVIVG01004101001 14810245 14815280 GO:0042773 ATP synthesis coupled electron transport The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP. IEA Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. IEA GO:0008137 NADH dehydrogenase (ubiquinone) activity GSVIVG01004101001 14810245 14815280 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. IEA GO:0008137 NADH dehydrogenase (ubiquinone) activity GSVIVG01004101001 14810245 14815280 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01004101001 14810245 14815280 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01004101001 14810245 14815280 GO:0042773 ATP synthesis coupled electron transport The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01004101001 14810245 14815280 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01007826001 8646692 8660814 GSVIVG01018889001 18940307 18950901 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018889001 18940307 18950901 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018889001 18940307 18950901 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018889001 18940307 18950901 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018889001 18940307 18950901 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018889001 18940307 18950901 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015552001 4831910 4836525 GSVIVG01000416001 7708815 7710847 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01000416001 7708815 7710847 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01000416001 7708815 7710847 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01000416001 7708815 7710847 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01000416001 7708815 7710847 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01000416001 7708815 7710847 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01000416001 7708815 7710847 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01000416001 7708815 7710847 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01015303001 2508463 2516376 GSVIVG01035582001 2493627 2494444 GSVIVG01035415001 1119678 1128024 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). IEA GO:0003755 peptidyl-prolyl cis-trans isomerase activity GSVIVG01016635001 2291552 2294174 GSVIVG01032702001 1388765 1389903 GO:0045941 positive regulation of transcription Any cellular process that activates or increases the frequency, rate or extent of transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01032702001 1388765 1389903 GO:0045941 positive regulation of transcription Any cellular process that activates or increases the frequency, rate or extent of transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01032702001 1388765 1389903 GO:0045941 positive regulation of transcription Any cellular process that activates or increases the frequency, rate or extent of transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any transcription regulator activity required for initiation or upregulation of transcription. IEA GO:0016563 transcription activator activity GSVIVG01031535001 17405635 17415691 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031535001 17405635 17415691 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031535001 17405635 17415691 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031535001 17405635 17415691 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024962001 5653634 5657941 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01032253001 13994836 14013898 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0005839 proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. IEA GO:0004175 endopeptidase activity GSVIVG01032253001 13994836 14013898 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0005839 proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. IEA Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. IEA GO:0004298 threonine-type endopeptidase activity GSVIVG01033232001 22343922 22354933 GO:0016023 cytoplasmic membrane-bounded vesicle A membrane-bounded vesicle found in the cytoplasm of the cell. IEA Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion. IEA GO:0004091 carboxylesterase activity GSVIVG01033232001 22343922 22354933 GO:0016023 cytoplasmic membrane-bounded vesicle A membrane-bounded vesicle found in the cytoplasm of the cell. IEA Catalysis of the reaction: S-formylglutathione + H2O = glutathione + formate. IEA GO:0018738 S-formylglutathione hydrolase activity GSVIVG01000744001 324723 332019 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01016669001 249146 256582 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016669001 249146 256582 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). IEA GO:0016769 transferase activity, transferring nitrogenous groups GSVIVG01016669001 249146 256582 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + methylthioadenosine. IEA GO:0016847 1-aminocyclopropane-1-carboxylate synthase activity GSVIVG01016669001 249146 256582 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01037680001 6806653 6810038 GO:0006099 tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. IEA GO:0045252 oxoglutarate dehydrogenase complex A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2). IEA Catalysis of the reaction: succinyl-CoA + dihydrolipoamide = CoA + S-succinyldihydrolipoamide. IEA GO:0004149 dihydrolipoyllysine-residue succinyltransferase activity GSVIVG01037680001 6806653 6810038 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0045252 oxoglutarate dehydrogenase complex A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2). IEA Catalysis of the reaction: succinyl-CoA + dihydrolipoamide = CoA + S-succinyldihydrolipoamide. IEA GO:0004149 dihydrolipoyllysine-residue succinyltransferase activity GSVIVG01037680001 6806653 6810038 GO:0006099 tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. IEA GO:0045252 oxoglutarate dehydrogenase complex A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2). IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01037680001 6806653 6810038 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0045252 oxoglutarate dehydrogenase complex A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2). IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01020042001 11232314 11234303 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01020042001 11232314 11234303 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01020042001 11232314 11234303 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01020042001 11232314 11234303 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033888001 17009966 17015205 GSVIVG01002264001 33773104 33773994 GSVIVG01010145001 16288424 16288864 GSVIVG01006634001 27181224 27185663 GO:0009073 aromatic amino acid family biosynthetic process The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). IEA Catalysis of the reaction: phosphoenolpyruvate + D-erythrose 4-phosphate + H2O = 2-dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + phosphate. IEA GO:0003849 3-deoxy-7-phosphoheptulonate synthase activity GSVIVG01030305001 9227520 9229339 GSVIVG01013864001 5544871 5565274 GSVIVG01017969001 5162320 5164612 GSVIVG01031671001 19947204 19951503 GSVIVG01023913001 2518586 2519032 GSVIVG01011688001 5118547 5122500 GSVIVG01036947001 17073636 17095499 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01019146001 16164435 16185831 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GSVIVG01033374001 21123189 21125175 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01028444001 7612837 7653678 GSVIVG01005249001 19833853 19834898 GSVIVG01000307001 2851713 2854530 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01000307001 2851713 2854530 Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium. IEA GO:0005544 calcium-dependent phospholipid binding GSVIVG01006741001 27940954 27941297 GSVIVG01034311001 14667433 14668023 GSVIVG01032607001 28790670 28796963 GSVIVG01018619001 12144995 12151388 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018619001 12144995 12151388 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01015253001 2133702 2137492 GSVIVG01028815001 18462909 18465345 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033629001 19114209 19119080 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01038055001 17114058 17114848 GSVIVG01017590001 11074013 11075004 GSVIVG01033265001 22011782 22040274 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01009874001 11997414 11997757 GSVIVG01016913001 2482869 2486756 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GSVIVG01029033001 10988736 10994229 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar. IEA GO:0008375 acetylglucosaminyltransferase activity GSVIVG01014641001 8126479 8128014 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01014641001 8126479 8128014 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the reaction: pectin + n H2O = n methanol + pectate. IEA GO:0030599 pectinesterase activity GSVIVG01014641001 8126479 8128014 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue. IEA GO:0045330 aspartyl esterase activity GSVIVG01010365001 19857100 19861937 GSVIVG01011783001 4174793 4176857 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01024591001 8591552 8594194 GSVIVG01004076001 14575286 14600455 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01004076001 14575286 14600455 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01004076001 14575286 14600455 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01004076001 14575286 14600455 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01037721001 7244482 7247977 GSVIVG01029462001 22579545 22596265 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01029462001 22579545 22596265 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01029462001 22579545 22596265 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01029462001 22579545 22596265 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029462001 22579545 22596265 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000007001 2645322 2647029 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01000007001 2645322 2647029 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01028275001 5241535 5243511 GSVIVG01014084001 244859 262438 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: bile acid(out) + Na+(out) = bile acid(in) + Na+(in). IEA GO:0008508 bile acid:sodium symporter activity GSVIVG01022926001 17899472 17907048 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01022926001 17899472 17907048 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01024545001 8980535 8985737 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01024545001 8980535 8985737 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01024545001 8980535 8985737 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01024545001 8980535 8985737 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01024545001 8980535 8985737 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011011001 2223472 2227876 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01011011001 2223472 2227876 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01016842001 1865448 1866048 GSVIVG01007451001 32007177 32008272 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA GSVIVG01007451001 32007177 32008272 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GSVIVG01017291001 6421453 6422261 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01017291001 6421453 6422261 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01017291001 6421453 6422261 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01017291001 6421453 6422261 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01015352001 2891542 2897423 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008397001 2499560 2504322 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01008397001 2499560 2504322 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008397001 2499560 2504322 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids. IEA GO:0004518 nuclease activity GSVIVG01023972001 2022219 2031739 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0000159 protein phosphatase type 2A complex A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit. IEA Modulation of the activity of the enzyme protein phosphatase type 2A. IEA GO:0008601 protein phosphatase type 2A regulator activity GSVIVG01023972001 2022219 2031739 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Modulation of the activity of the enzyme protein phosphatase type 2A. IEA GO:0008601 protein phosphatase type 2A regulator activity GSVIVG01023972001 2022219 2031739 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Modulation of the activity of the enzyme protein phosphatase type 2A. IEA GO:0008601 protein phosphatase type 2A regulator activity GSVIVG01023972001 2022219 2031739 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0000159 protein phosphatase type 2A complex A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit. IEA Modulation of the activity of the enzyme protein phosphatase type 2A. IEA GO:0008601 protein phosphatase type 2A regulator activity GSVIVG01023972001 2022219 2031739 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Modulation of the activity of the enzyme protein phosphatase type 2A. IEA GO:0008601 protein phosphatase type 2A regulator activity GSVIVG01023972001 2022219 2031739 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Modulation of the activity of the enzyme protein phosphatase type 2A. IEA GO:0008601 protein phosphatase type 2A regulator activity GSVIVG01023972001 2022219 2031739 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0000159 protein phosphatase type 2A complex A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit. IEA Modulation of the activity of the enzyme protein phosphatase type 2A. IEA GO:0008601 protein phosphatase type 2A regulator activity GSVIVG01023972001 2022219 2031739 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Modulation of the activity of the enzyme protein phosphatase type 2A. IEA GO:0008601 protein phosphatase type 2A regulator activity GSVIVG01023972001 2022219 2031739 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Modulation of the activity of the enzyme protein phosphatase type 2A. IEA GO:0008601 protein phosphatase type 2A regulator activity GSVIVG01023972001 2022219 2031739 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0000159 protein phosphatase type 2A complex A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit. IEA Modulation of the activity of the enzyme protein phosphatase type 2A. IEA GO:0008601 protein phosphatase type 2A regulator activity GSVIVG01023972001 2022219 2031739 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Modulation of the activity of the enzyme protein phosphatase type 2A. IEA GO:0008601 protein phosphatase type 2A regulator activity GSVIVG01023972001 2022219 2031739 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Modulation of the activity of the enzyme protein phosphatase type 2A. IEA GO:0008601 protein phosphatase type 2A regulator activity GSVIVG01023972001 2022219 2031739 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0000159 protein phosphatase type 2A complex A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01023972001 2022219 2031739 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01023972001 2022219 2031739 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01023972001 2022219 2031739 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0000159 protein phosphatase type 2A complex A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01023972001 2022219 2031739 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01023972001 2022219 2031739 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01023972001 2022219 2031739 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0000159 protein phosphatase type 2A complex A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01023972001 2022219 2031739 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01023972001 2022219 2031739 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01023972001 2022219 2031739 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0000159 protein phosphatase type 2A complex A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01023972001 2022219 2031739 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01023972001 2022219 2031739 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01006152001 42189951 42191812 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01006152001 42189951 42191812 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01016236001 6106615 6118411 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01016236001 6106615 6118411 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01021204001 2539085 2543463 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021204001 2539085 2543463 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021204001 2539085 2543463 GO:0009082 branched chain family amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021204001 2539085 2543463 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021204001 2539085 2543463 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+. IEA GO:0004455 ketol-acid reductoisomerase activity GSVIVG01021204001 2539085 2543463 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the reaction: (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+. IEA GO:0004455 ketol-acid reductoisomerase activity GSVIVG01021204001 2539085 2543463 GO:0009082 branched chain family amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. IEA Catalysis of the reaction: (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+. IEA GO:0004455 ketol-acid reductoisomerase activity GSVIVG01021204001 2539085 2543463 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+. IEA GO:0004455 ketol-acid reductoisomerase activity GSVIVG01021204001 2539085 2543463 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01021204001 2539085 2543463 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01021204001 2539085 2543463 GO:0009082 branched chain family amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01021204001 2539085 2543463 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01021204001 2539085 2543463 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021204001 2539085 2543463 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021204001 2539085 2543463 GO:0009082 branched chain family amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021204001 2539085 2543463 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021204001 2539085 2543463 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01021204001 2539085 2543463 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01021204001 2539085 2543463 GO:0009082 branched chain family amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01021204001 2539085 2543463 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01003752001 12368847 12369361 GSVIVG01036412001 4812719 4813057 GSVIVG01016309001 5269327 5285633 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01026845001 20011193 20016163 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026845001 20011193 20016163 GO:0009396 folic acid and derivative biosynthetic process The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026845001 20011193 20016163 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026845001 20011193 20016163 GO:0009396 folic acid and derivative biosynthetic process The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01018579001 12961190 12962599 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GSVIVG01026134001 12745172 12746877 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01026134001 12745172 12746877 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01026134001 12745172 12746877 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01026134001 12745172 12746877 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01017325001 6729565 6731393 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other. IEA GO:0005337 nucleoside transmembrane transporter activity GSVIVG01000697001 15779470 15780216 GSVIVG01032184001 21755973 21758820 GSVIVG01025901001 27377308 27377568 GSVIVG01024739001 7318757 7329915 GSVIVG01032141001 22240211 22242559 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032141001 22240211 22242559 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025261001 2619824 2620777 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025261001 2619824 2620777 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). IEA GO:0016769 transferase activity, transferring nitrogenous groups GSVIVG01025261001 2619824 2620777 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01033479001 20378523 20380501 GSVIVG01007812001 8783442 8786594 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01026887001 19644739 19645305 GSVIVG01026640001 20807989 20822529 GSVIVG01019946001 12603604 12606875 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019946001 12603604 12606875 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019946001 12603604 12606875 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019946001 12603604 12606875 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019946001 12603604 12606875 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019946001 12603604 12606875 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019946001 12603604 12606875 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019946001 12603604 12606875 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019946001 12603604 12606875 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019946001 12603604 12606875 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019946001 12603604 12606875 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019946001 12603604 12606875 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019946001 12603604 12606875 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019946001 12603604 12606875 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019946001 12603604 12606875 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019946001 12603604 12606875 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019946001 12603604 12606875 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019946001 12603604 12606875 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019946001 12603604 12606875 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019946001 12603604 12606875 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019946001 12603604 12606875 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. IEA GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity GSVIVG01019946001 12603604 12606875 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. IEA GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity GSVIVG01019946001 12603604 12606875 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. IEA GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity GSVIVG01019946001 12603604 12606875 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. IEA GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity GSVIVG01019946001 12603604 12606875 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. IEA GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity GSVIVG01019946001 12603604 12606875 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. IEA GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity GSVIVG01019946001 12603604 12606875 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. IEA GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity GSVIVG01019946001 12603604 12606875 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. IEA GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity GSVIVG01019946001 12603604 12606875 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. IEA GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity GSVIVG01019946001 12603604 12606875 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. IEA GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity GSVIVG01019946001 12603604 12606875 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. IEA GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity GSVIVG01019946001 12603604 12606875 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. IEA GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity GSVIVG01019946001 12603604 12606875 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. IEA GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity GSVIVG01019946001 12603604 12606875 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. IEA GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity GSVIVG01019946001 12603604 12606875 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. IEA GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity GSVIVG01019946001 12603604 12606875 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. IEA GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity GSVIVG01019946001 12603604 12606875 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. IEA GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity GSVIVG01019946001 12603604 12606875 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. IEA GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity GSVIVG01019946001 12603604 12606875 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. IEA GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity GSVIVG01019946001 12603604 12606875 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. IEA GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity GSVIVG01019946001 12603604 12606875 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01019946001 12603604 12606875 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01019946001 12603604 12606875 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01019946001 12603604 12606875 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01019946001 12603604 12606875 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01019946001 12603604 12606875 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01019946001 12603604 12606875 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01019946001 12603604 12606875 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01019946001 12603604 12606875 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01019946001 12603604 12606875 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01019946001 12603604 12606875 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01019946001 12603604 12606875 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01019946001 12603604 12606875 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01019946001 12603604 12606875 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01019946001 12603604 12606875 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01019946001 12603604 12606875 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01019946001 12603604 12606875 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01019946001 12603604 12606875 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01019946001 12603604 12606875 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01019946001 12603604 12606875 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01019946001 12603604 12606875 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019946001 12603604 12606875 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019946001 12603604 12606875 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019946001 12603604 12606875 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019946001 12603604 12606875 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019946001 12603604 12606875 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019946001 12603604 12606875 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019946001 12603604 12606875 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019946001 12603604 12606875 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019946001 12603604 12606875 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019946001 12603604 12606875 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019946001 12603604 12606875 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019946001 12603604 12606875 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019946001 12603604 12606875 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019946001 12603604 12606875 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019946001 12603604 12606875 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019946001 12603604 12606875 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019946001 12603604 12606875 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019946001 12603604 12606875 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019946001 12603604 12606875 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019946001 12603604 12606875 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019946001 12603604 12606875 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019946001 12603604 12606875 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019946001 12603604 12606875 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019946001 12603604 12606875 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019946001 12603604 12606875 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019946001 12603604 12606875 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019946001 12603604 12606875 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019946001 12603604 12606875 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019946001 12603604 12606875 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019946001 12603604 12606875 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019946001 12603604 12606875 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019946001 12603604 12606875 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019946001 12603604 12606875 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019946001 12603604 12606875 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019946001 12603604 12606875 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019946001 12603604 12606875 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019946001 12603604 12606875 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019946001 12603604 12606875 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019946001 12603604 12606875 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011834001 3757151 3759858 GSVIVG01015399001 3276161 3276244 GSVIVG01010840001 23266927 23286035 GSVIVG01025865001 11031629 11038419 Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01032081001 22911900 22914178 GSVIVG01029179001 18903622 18913533 GO:0015833 peptide transport The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029179001 18903622 18913533 GO:0015833 peptide transport The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of, within or between cells. IEA GO:0015197 peptide transporter activity GSVIVG01025904001 27357687 27357962 GSVIVG01011045001 1998020 2001634 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01011045001 1998020 2001634 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01011045001 1998020 2001634 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01011045001 1998020 2001634 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026821001 20204216 20209911 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026821001 20204216 20209911 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026821001 20204216 20209911 GO:0045226 extracellular polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026821001 20204216 20209911 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026821001 20204216 20209911 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026821001 20204216 20209911 GO:0045226 extracellular polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026821001 20204216 20209911 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + NADPH + H+. IEA GO:0008831 dTDP-4-dehydrorhamnose reductase activity GSVIVG01026821001 20204216 20209911 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + NADPH + H+. IEA GO:0008831 dTDP-4-dehydrorhamnose reductase activity GSVIVG01026821001 20204216 20209911 GO:0045226 extracellular polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. IEA Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + NADPH + H+. IEA GO:0008831 dTDP-4-dehydrorhamnose reductase activity GSVIVG01026821001 20204216 20209911 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01026821001 20204216 20209911 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01026821001 20204216 20209911 GO:0045226 extracellular polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01027489001 16328642 16359955 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain. IEA GO:0004177 aminopeptidase activity GSVIVG01027489001 16328642 16359955 GO:0009987 cellular process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. IEA Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain. IEA GO:0004177 aminopeptidase activity GSVIVG01027489001 16328642 16359955 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008235 metalloexopeptidase activity GSVIVG01027489001 16328642 16359955 GO:0009987 cellular process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008235 metalloexopeptidase activity GSVIVG01027184001 17188042 17190428 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01027184001 17188042 17190428 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01016663001 206133 216225 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01016663001 206133 216225 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01019252001 2516929 2517045 GSVIVG01035381001 905619 908738 GSVIVG01008805001 2259998 2287308 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008805001 2259998 2287308 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives. IEA GO:0018024 histone-lysine N-methyltransferase activity GSVIVG01031023001 21063677 21068377 GSVIVG01023888001 2657817 2659770 GSVIVG01033093001 25661397 25665709 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01015110001 1109139 1112181 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01015110001 1109139 1112181 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01015110001 1109139 1112181 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015935 small ribosomal subunit The smaller of the two subunits of a ribosome. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01015110001 1109139 1112181 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01015110001 1109139 1112181 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01015110001 1109139 1112181 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015935 small ribosomal subunit The smaller of the two subunits of a ribosome. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01033594001 19457871 19462315 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01010266001 18601359 18606800 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01010266001 18601359 18606800 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01010266001 18601359 18606800 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01010266001 18601359 18606800 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01036093001 20760948 20767241 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036093001 20760948 20767241 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01036093001 20760948 20767241 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor), with the acyl group being converted into alkyl on transfer. IEA GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer GSVIVG01032966001 24658572 24660429 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01029607001 20817388 20817910 GSVIVG01003881001 13092635 13102066 GSVIVG01019300001 1678278 1678553 GSVIVG01035360001 743662 745109 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. IEA GO:0016791 phosphatase activity GSVIVG01031336001 276555 277800 GSVIVG01035758001 4056576 4057713 GSVIVG01022547001 4657108 4667828 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01022547001 4657108 4667828 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01015920001 15127112 15133749 GSVIVG01033846001 17280622 17291901 GSVIVG01026613001 21017335 21020793 GSVIVG01024399001 2100032 2102482 GSVIVG01026898001 19576430 19588303 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01026898001 19576430 19588303 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01026898001 19576430 19588303 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01026898001 19576430 19588303 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01026898001 19576430 19588303 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01026898001 19576430 19588303 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01026898001 19576430 19588303 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-A receptors function as chloride channels. IEA GO:0004890 GABA-A receptor activity GSVIVG01026898001 19576430 19588303 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-A receptors function as chloride channels. IEA GO:0004890 GABA-A receptor activity GSVIVG01026898001 19576430 19588303 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01026898001 19576430 19588303 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01026898001 19576430 19588303 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026898001 19576430 19588303 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007283001 31258929 31261737 GSVIVG01032754001 1003921 1006908 GO:0006826 iron ion transport The directed movement of iron (Fe) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032754001 1003921 1006908 GO:0006879 cellular iron ion homeostasis Any process involved in the maintenance of an internal steady-state of iron ions at the level of a cell. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032754001 1003921 1006908 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032754001 1003921 1006908 GO:0006826 iron ion transport The directed movement of iron (Fe) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with ferric iron, Fe(III). IEA GO:0008199 ferric iron binding GSVIVG01032754001 1003921 1006908 GO:0006879 cellular iron ion homeostasis Any process involved in the maintenance of an internal steady-state of iron ions at the level of a cell. IEA Interacting selectively and non-covalently with ferric iron, Fe(III). IEA GO:0008199 ferric iron binding GSVIVG01032754001 1003921 1006908 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with ferric iron, Fe(III). IEA GO:0008199 ferric iron binding GSVIVG01032754001 1003921 1006908 GO:0006826 iron ion transport The directed movement of iron (Fe) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01032754001 1003921 1006908 GO:0006879 cellular iron ion homeostasis Any process involved in the maintenance of an internal steady-state of iron ions at the level of a cell. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01032754001 1003921 1006908 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01032754001 1003921 1006908 GO:0006826 iron ion transport The directed movement of iron (Fe) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01032754001 1003921 1006908 GO:0006879 cellular iron ion homeostasis Any process involved in the maintenance of an internal steady-state of iron ions at the level of a cell. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01032754001 1003921 1006908 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01028170001 4380862 4382867 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01028170001 4380862 4382867 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the reaction: pectin + n H2O = n methanol + pectate. IEA GO:0030599 pectinesterase activity GSVIVG01028170001 4380862 4382867 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue. IEA GO:0045330 aspartyl esterase activity GSVIVG01014934001 12256140 12256888 GSVIVG01010007001 13408109 13413196 GSVIVG01037397001 14388028 14390287 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01008543001 972996 979490 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008543001 972996 979490 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008543001 972996 979490 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008543001 972996 979490 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008543001 972996 979490 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01008543001 972996 979490 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01008543001 972996 979490 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. IEA GO:0048037 cofactor binding GSVIVG01008543001 972996 979490 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. IEA GO:0048037 cofactor binding GSVIVG01013056001 9039188 9039439 GSVIVG01022656001 14179266 14180746 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01007806001 8832452 8841207 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01007806001 8832452 8841207 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01007806001 8832452 8841207 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01007340001 31437695 31439547 GO:0015886 heme transport The directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells. IEA GO:0015232 heme transporter activity GSVIVG01007340001 31437695 31439547 GO:0015886 heme transport The directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells. IEA GO:0015232 heme transporter activity GSVIVG01007340001 31437695 31439547 GO:0017004 cytochrome complex assembly The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells. IEA GO:0015232 heme transporter activity GSVIVG01007340001 31437695 31439547 GO:0017004 cytochrome complex assembly The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells. IEA GO:0015232 heme transporter activity GSVIVG01028637001 11382391 11388522 GO:0009416 response to light stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01028637001 11382391 11388522 GO:0009416 response to light stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01026859001 19879102 19879293 GSVIVG01003602001 11171266 11174787 Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01012027001 2088886 2090223 GSVIVG01013399001 708207 712862 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01013399001 708207 712862 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. IEA GO:0004722 protein serine/threonine phosphatase activity GSVIVG01037591001 10304621 10339338 Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity. IEA GO:0004721 phosphoprotein phosphatase activity GSVIVG01037591001 10304621 10339338 Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01037591001 10304621 10339338 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01037591001 10304621 10339338 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01037591001 10304621 10339338 Interacting selectively and non-covalently with manganese (Mn) ions. IEA GO:0030145 manganese ion binding GSVIVG01006271001 24386272 24393676 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01006271001 24386272 24393676 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01006271001 24386272 24393676 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01006271001 24386272 24393676 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01006271001 24386272 24393676 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01006271001 24386272 24393676 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01006271001 24386272 24393676 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01006271001 24386272 24393676 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01033806001 17623737 17629051 GSVIVG01007470001 32130265 32130531 GSVIVG01037326001 15656309 15657587 GSVIVG01032950001 24534256 24538272 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01004302001 37994958 37999118 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01004302001 37994958 37999118 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01004302001 37994958 37999118 GO:0006434 seryl-tRNA aminoacylation The process of coupling serine to seryl-tRNA, catalyzed by seryl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01004302001 37994958 37999118 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01004302001 37994958 37999118 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01004302001 37994958 37999118 GO:0006434 seryl-tRNA aminoacylation The process of coupling serine to seryl-tRNA, catalyzed by seryl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01004302001 37994958 37999118 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser). IEA GO:0004828 serine-tRNA ligase activity GSVIVG01004302001 37994958 37999118 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser). IEA GO:0004828 serine-tRNA ligase activity GSVIVG01004302001 37994958 37999118 GO:0006434 seryl-tRNA aminoacylation The process of coupling serine to seryl-tRNA, catalyzed by seryl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser). IEA GO:0004828 serine-tRNA ligase activity GSVIVG01004302001 37994958 37999118 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01004302001 37994958 37999118 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01004302001 37994958 37999118 GO:0006434 seryl-tRNA aminoacylation The process of coupling serine to seryl-tRNA, catalyzed by seryl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025662001 13119115 13125327 GSVIVG01020437001 19442860 19461262 GSVIVG01026429001 23677511 23685104 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01005144001 18527810 18529255 GSVIVG01034969001 538908 542600 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0016272 prefoldin complex A multisubunit chaperone that acts to delivers unfolded proteins to cytosolic chaperonin. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01019916001 4434338 4436260 GSVIVG01008370001 2743722 2767609 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01008370001 2743722 2767609 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01008370001 2743722 2767609 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01008370001 2743722 2767609 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01008370001 2743722 2767609 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01008370001 2743722 2767609 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01008370001 2743722 2767609 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01008370001 2743722 2767609 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01008370001 2743722 2767609 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01004720001 15504666 15506710 GSVIVG01019950001 12478585 12504600 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01032337001 15195030 15196758 GSVIVG01036558001 23435308 23438477 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01036558001 23435308 23438477 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01036558001 23435308 23438477 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01036558001 23435308 23438477 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01036558001 23435308 23438477 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01017021001 3513049 3513279 GSVIVG01033757001 18062601 18063224 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01033757001 18062601 18063224 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01033757001 18062601 18063224 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01033757001 18062601 18063224 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01018274001 12155937 12183814 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01016586001 2603259 2605328 GSVIVG01011615001 5948429 5953185 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01011615001 5948429 5953185 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01011615001 5948429 5953185 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01011615001 5948429 5953185 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01011615001 5948429 5953185 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008862001 2881693 2885346 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01008862001 2881693 2885346 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of hydroxylation at the 7-methyl group of chlorophyllide a, according to the reactions: chlorophyllide a + O2 + NADPH + H+ = 7-hydroxychlorophyllide a + H2O + NADP+ and 7-hydroxychlorophyllide a + O2 + NADPH + H+ = chlorophyllide b + 2 H2O + NADP+. IEA GO:0010277 chlorophyllide a oxygenase activity GSVIVG01008862001 2881693 2885346 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008862001 2881693 2885346 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. IEA GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GSVIVG01008862001 2881693 2885346 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051537 2 iron, 2 sulfur cluster binding GSVIVG01011368001 29015137 29019210 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GSVIVG01000181001 15952303 15953886 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01000181001 15952303 15953886 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01000181001 15952303 15953886 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01000181001 15952303 15953886 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01020468001 18967468 18968195 GSVIVG01034308001 14596804 14608298 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01034308001 14596804 14608298 Catalysis of the reaction: ATP + shikimate = ADP + shikimate 3-phosphate. IEA GO:0004765 shikimate kinase activity GSVIVG01034308001 14596804 14608298 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034308001 14596804 14608298 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01031643001 19489540 19490647 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01003469001 10549147 10553763 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003469001 10549147 10553763 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003469001 10549147 10553763 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01003469001 10549147 10553763 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01017869001 4144869 4176378 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain. IEA GO:0004177 aminopeptidase activity GSVIVG01011364001 28982934 28985707 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GSVIVG01006375001 25346801 25351642 Catalysis of the removal of a phosphate group from phosphorylated myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol. IEA GO:0004437 inositol or phosphatidylinositol phosphatase activity GSVIVG01003530001 76201 78315 GSVIVG01020088001 10433550 10450118 GSVIVG01019569001 1667929 1673264 GSVIVG01007233001 30976477 30977781 GSVIVG01001195001 913500 923038 The action of a molecule that contributes to the structural integrity of a cytoskeletal structure. IEA GO:0005200 structural constituent of cytoskeleton GSVIVG01017723001 2941406 2943466 GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA GSVIVG01036324001 3823271 3847421 GSVIVG01010019001 13498401 13504533 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01032720001 1277524 1278824 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. IEA GO:0016597 amino acid binding GSVIVG01032720001 1277524 1278824 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. IEA GO:0016597 amino acid binding GSVIVG01032720001 1277524 1278824 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01032720001 1277524 1278824 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01025487001 391295 391874 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01025487001 391295 391874 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01025487001 391295 391874 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01025487001 391295 391874 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01008391001 2563708 2564480 GSVIVG01008838001 2629486 2630109 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01008838001 2629486 2630109 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01031327001 337889 340868 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005764 lysosome A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01031327001 337889 340868 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA GO:0005764 lysosome A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01031327001 337889 340868 GO:0006665 sphingolipid metabolic process The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). IEA GO:0005764 lysosome A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01031173001 1510799 1520544 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01015045001 701295 703811 GO:0009765 photosynthesis, light harvesting Absorption and transfer of the energy absorbed from light photons between photosystem reaction centers. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA GSVIVG01015045001 701295 703811 GO:0009765 photosynthesis, light harvesting Absorption and transfer of the energy absorbed from light photons between photosystem reaction centers. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01005914001 22607386 22608902 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01006279001 24471534 24473095 GSVIVG01023978001 1950825 1954840 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01024596001 8561978 8564377 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01024596001 8561978 8564377 GO:0042744 hydrogen peroxide catabolic process The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2). IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01024596001 8561978 8564377 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01024596001 8561978 8564377 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01024596001 8561978 8564377 GO:0042744 hydrogen peroxide catabolic process The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2). IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01024596001 8561978 8564377 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01024596001 8561978 8564377 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01024596001 8561978 8564377 GO:0042744 hydrogen peroxide catabolic process The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2). IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01024596001 8561978 8564377 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01024596001 8561978 8564377 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024596001 8561978 8564377 GO:0042744 hydrogen peroxide catabolic process The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2). IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024596001 8561978 8564377 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024596001 8561978 8564377 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01024596001 8561978 8564377 GO:0042744 hydrogen peroxide catabolic process The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2). IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01024596001 8561978 8564377 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01024596001 8561978 8564377 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01024596001 8561978 8564377 GO:0042744 hydrogen peroxide catabolic process The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2). IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01024596001 8561978 8564377 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01015011001 417267 423378 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01006510001 42540178 42541407 GSVIVG01038385001 11547695 11548135 GSVIVG01036121001 20420026 20423006 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01015372001 3082194 3082613 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005875 microtubule associated complex Any multimeric complex connected to a microtubule. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01020835001 1365938 1380181 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01020835001 1365938 1380181 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA Catalysis of the reaction: formyl-L-methionyl peptide + H2O = formate + methionyl peptide. IEA GO:0042586 peptide deformylase activity GSVIVG01018070001 6213952 6215356 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01000333001 11515237 11518011 GSVIVG01012649001 345998 347743 GSVIVG01013051001 9164518 9172074 GSVIVG01028406001 7239514 7258687 GSVIVG01025923001 27200245 27219980 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025923001 27200245 27219980 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0010181 FMN binding GSVIVG01025923001 27200245 27219980 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022363001 19019747 19027670 GSVIVG01005935001 22847451 22882607 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01005935001 22847451 22882607 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038061001 17216691 17216967 GSVIVG01038498001 10426468 10426770 GSVIVG01026829001 20126961 20131574 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026829001 20126961 20131574 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026829001 20126961 20131574 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026829001 20126961 20131574 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026829001 20126961 20131574 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026829001 20126961 20131574 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026829001 20126961 20131574 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01026829001 20126961 20131574 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01026829001 20126961 20131574 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01026829001 20126961 20131574 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01026829001 20126961 20131574 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01026829001 20126961 20131574 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01027398001 17080496 17082070 GSVIVG01035907001 5652935 5655912 GSVIVG01033493001 20258173 20262901 Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01013536001 2562418 2562972 GSVIVG01026664001 4545709 4546219 GSVIVG01027853001 8652756 8665137 GO:0016070 RNA metabolic process The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027853001 8652756 8665137 GO:0016070 RNA metabolic process The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01019249001 2592629 2593706 GSVIVG01032387001 26874053 26878810 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01010258001 18500365 18519866 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01010258001 18500365 18519866 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01010258001 18500365 18519866 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010258001 18500365 18519866 Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01027431001 16791072 16792622 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01030683001 13478735 13480574 GSVIVG01021786001 7445042 7452757 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the elimination of H2S or substituted H2S. IEA GO:0016846 carbon-sulfur lyase activity GSVIVG01035525001 2012453 2019830 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035525001 2012453 2019830 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035525001 2012453 2019830 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035525001 2012453 2019830 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035525001 2012453 2019830 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035525001 2012453 2019830 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035525001 2012453 2019830 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035525001 2012453 2019830 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035525001 2012453 2019830 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035525001 2012453 2019830 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035525001 2012453 2019830 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035525001 2012453 2019830 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035525001 2012453 2019830 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01035525001 2012453 2019830 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01035525001 2012453 2019830 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01035525001 2012453 2019830 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01035525001 2012453 2019830 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01035525001 2012453 2019830 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01035525001 2012453 2019830 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01035525001 2012453 2019830 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01035525001 2012453 2019830 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01035525001 2012453 2019830 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01035525001 2012453 2019830 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01035525001 2012453 2019830 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01035525001 2012453 2019830 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01035525001 2012453 2019830 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01035525001 2012453 2019830 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01035525001 2012453 2019830 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01035525001 2012453 2019830 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01035525001 2012453 2019830 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01027611001 15060959 15061701 GSVIVG01012614001 34251 35797 GSVIVG01023967001 2066434 2081541 GSVIVG01025440001 797653 798551 GSVIVG01009092001 4974799 4979304 GSVIVG01016551001 2872618 2879505 Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01016551001 2872618 2879505 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01027130001 17583739 17587199 GSVIVG01035401001 1029311 1029946 GSVIVG01030494001 6163272 6173450 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030494001 6163272 6173450 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030494001 6163272 6173450 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030494001 6163272 6173450 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01030494001 6163272 6173450 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01030494001 6163272 6173450 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01030494001 6163272 6173450 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01030494001 6163272 6173450 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01030494001 6163272 6173450 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01029934001 1698601 1718622 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01029934001 1698601 1718622 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01029934001 1698601 1718622 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01029934001 1698601 1718622 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01027399001 17070474 17076625 GSVIVG01000751001 369489 375593 GO:0006614 SRP-dependent cotranslational protein targeting to membrane The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. IEA GO:0048500 signal recognition particle A complex of protein and RNA which facilitates translocation of proteins across membranes. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000751001 369489 375593 GO:0045900 negative regulation of translational elongation Any process that stops, prevents or reduces the frequency, rate or extent of translational elongation. IEA GO:0048500 signal recognition particle A complex of protein and RNA which facilitates translocation of proteins across membranes. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000751001 369489 375593 GO:0006614 SRP-dependent cotranslational protein targeting to membrane The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. IEA GO:0048500 signal recognition particle A complex of protein and RNA which facilitates translocation of proteins across membranes. IEA Interacting selectively and non-covalently with 7S RNA, the RNA component of the signal recognition particle (SRP). IEA GO:0008312 7S RNA binding GSVIVG01000751001 369489 375593 GO:0045900 negative regulation of translational elongation Any process that stops, prevents or reduces the frequency, rate or extent of translational elongation. IEA GO:0048500 signal recognition particle A complex of protein and RNA which facilitates translocation of proteins across membranes. IEA Interacting selectively and non-covalently with 7S RNA, the RNA component of the signal recognition particle (SRP). IEA GO:0008312 7S RNA binding GSVIVG01031906001 5292039 5292426 GSVIVG01016212001 6558778 6562740 GSVIVG01008480001 1502921 1509601 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of potassium ions (K+) from one side of a membrane to the other. IEA GO:0015079 potassium ion transmembrane transporter activity GSVIVG01020541001 4668184 4669328 GSVIVG01038001001 12328573 12329648 GSVIVG01037440001 13702936 13724348 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01037109001 29077208 29084742 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01037109001 29077208 29084742 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037109001 29077208 29084742 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01028011001 3185217 3187278 GSVIVG01034632001 13683950 13686011 GSVIVG01018105001 6592179 6599657 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018105001 6592179 6599657 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01010215001 17750966 17753365 GSVIVG01025958001 26576670 26586440 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025958001 26576670 26586440 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025958001 26576670 26586440 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025958001 26576670 26586440 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025958001 26576670 26586440 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025958001 26576670 26586440 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025958001 26576670 26586440 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01025958001 26576670 26586440 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01020396001 20150486 20152848 GSVIVG01017915001 4619229 4633132 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01017915001 4619229 4633132 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01017915001 4619229 4633132 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01017915001 4619229 4633132 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01017915001 4619229 4633132 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017915001 4619229 4633132 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01012142001 1082989 1085765 GSVIVG01024091001 1215576 1222056 GSVIVG01017751001 3146999 3150745 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01017751001 3146999 3150745 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01030132001 10120984 10123984 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01011226001 9834087 9835231 Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01011226001 9834087 9835231 Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01011226001 9834087 9835231 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01011226001 9834087 9835231 Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01011841001 3720067 3721588 The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01023697001 9496524 9499281 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01023697001 9496524 9499281 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01005196001 19061963 19064180 GSVIVG01001773001 3000760 3007729 GSVIVG01013213001 6680635 6681662 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01034432001 16302274 16310584 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01034432001 16302274 16310584 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01034432001 16302274 16310584 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034432001 16302274 16310584 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034432001 16302274 16310584 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01034432001 16302274 16310584 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01020890001 17723726 17723932 GSVIVG01030850001 17568522 17569355 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01009382001 7901913 7904129 GSVIVG01028208001 4628142 4637596 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01033916001 16759329 16764289 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033916001 16759329 16764289 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033916001 16759329 16764289 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01033916001 16759329 16764289 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01033916001 16759329 16764289 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033916001 16759329 16764289 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033916001 16759329 16764289 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033916001 16759329 16764289 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033916001 16759329 16764289 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01033916001 16759329 16764289 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01033916001 16759329 16764289 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01033916001 16759329 16764289 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01025659001 13199520 13205426 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025659001 13199520 13205426 Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01033658001 18894017 18895661 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01033658001 18894017 18895661 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01033658001 18894017 18895661 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01033658001 18894017 18895661 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01033658001 18894017 18895661 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01033658001 18894017 18895661 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01033658001 18894017 18895661 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01033658001 18894017 18895661 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01002825001 36827958 36828575 GO:0006487 protein amino acid N-linked glycosylation A protein amino acid glycosylation process in which a sugar unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan. IEA GO:0000139 Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus. IEA Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + alpha-D-mannosyl-1,3-(R1)-beta-D-mannosyl-R2 = UDP + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(R1)-beta-D-mannosyl-R2. IEA GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity GSVIVG01035945001 6279733 6280638 GSVIVG01035950001 6370073 6380258 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01021583001 7424996 7435560 GSVIVG01020794001 1905862 1915894 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01020794001 1905862 1915894 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01020794001 1905862 1915894 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01020794001 1905862 1915894 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01020794001 1905862 1915894 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01020794001 1905862 1915894 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01020794001 1905862 1915894 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01020794001 1905862 1915894 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01020794001 1905862 1915894 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020794001 1905862 1915894 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020794001 1905862 1915894 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01020794001 1905862 1915894 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01022879001 18475992 18486642 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01022879001 18475992 18486642 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01006973001 29495312 29502410 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01006973001 29495312 29502410 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01006973001 29495312 29502410 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01006973001 29495312 29502410 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01036951001 17048117 17048305 GSVIVG01021862001 6386355 6394481 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021862001 6386355 6394481 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01021862001 6386355 6394481 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01010005001 13388960 13391077 GSVIVG01026784001 7108580 7110819 GSVIVG01020425001 19625057 19625757 GSVIVG01027631001 14841403 14849398 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01027631001 14841403 14849398 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01014022001 9082240 9091398 Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum. IEA GO:0003993 acid phosphatase activity GSVIVG01020743001 2416399 2421014 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01020743001 2416399 2421014 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01036474001 22511577 22526847 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036474001 22511577 22526847 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01034352001 17628254 17630276 GSVIVG01033086001 25610483 25614362 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01033086001 25610483 25614362 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01022826001 19013270 19023977 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01022826001 19013270 19023977 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01021966001 4999446 5000880 GSVIVG01018516001 13978329 13986616 GSVIVG01037846001 7192504 7193911 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01030517001 6419765 6422307 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA GSVIVG01008003001 6769396 6770752 GSVIVG01037140001 28693228 28694490 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01037140001 28693228 28694490 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01013706001 2836667 2853070 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01024114001 978958 981975 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024114001 978958 981975 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021281001 3393479 3400972 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016936001 2712168 2725531 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01016936001 2712168 2725531 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01016936001 2712168 2725531 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01016936001 2712168 2725531 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016936001 2712168 2725531 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009632001 10062673 10065015 Catalysis of the removal of a phosphate group from phosphorylated myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol. IEA GO:0004437 inositol or phosphatidylinositol phosphatase activity GSVIVG01019262001 2412845 2414893 GSVIVG01019231001 3017026 3019967 GSVIVG01008977001 3980569 3988108 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01000087001 3331672 3368379 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01000087001 3331672 3368379 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01000087001 3331672 3368379 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01000087001 3331672 3368379 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01000087001 3331672 3368379 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01000087001 3331672 3368379 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01000087001 3331672 3368379 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and primer. IEA GO:0003887 DNA-directed DNA polymerase activity GSVIVG01000087001 3331672 3368379 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and primer. IEA GO:0003887 DNA-directed DNA polymerase activity GSVIVG01027577001 15406740 15424492 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01027577001 15406740 15424492 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01027577001 15406740 15424492 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01027577001 15406740 15424492 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01027577001 15406740 15424492 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01027577001 15406740 15424492 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01027577001 15406740 15424492 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01027577001 15406740 15424492 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01027577001 15406740 15424492 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01001213001 739645 740698 GSVIVG01021590001 7614655 7630785 GSVIVG01012804001 5542394 5543599 GSVIVG01029031001 10941513 10941653 GSVIVG01019109001 16664476 16666741 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01019109001 16664476 16666741 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01018606001 12359339 12360092 Stops, prevents or reduces the activity of an enzyme. IEA GO:0004857 enzyme inhibitor activity GSVIVG01018606001 12359339 12360092 Catalysis of the reaction: pectin + n H2O = n methanol + pectate. IEA GO:0030599 pectinesterase activity GSVIVG01021349001 4344243 4346118 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01021349001 4344243 4346118 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01026927001 19338784 19344048 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01009657001 10239610 10244192 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009657001 10239610 10244192 GO:0006284 base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009657001 10239610 10244192 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the hydrolysis of alkylated DNA; only recognizes and removes the alkylated base 3-methyladenine by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site. IEA GO:0008725 DNA-3-methyladenine glycosylase I activity GSVIVG01009657001 10239610 10244192 GO:0006284 base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. IEA Catalysis of the hydrolysis of alkylated DNA; only recognizes and removes the alkylated base 3-methyladenine by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site. IEA GO:0008725 DNA-3-methyladenine glycosylase I activity GSVIVG01024167001 644718 647153 GO:0006527 arginine catabolic process The chemical reactions and pathways resulting in the breakdown of arginine, 2-amino-5-(carbamimidamido)pentanoic acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024167001 644718 647153 GO:0008295 spermidine biosynthetic process The chemical reactions and pathways resulting in the formation of spermidine, N-(3-aminopropyl)-1,4-diaminobutane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024167001 644718 647153 GO:0006527 arginine catabolic process The chemical reactions and pathways resulting in the breakdown of arginine, 2-amino-5-(carbamimidamido)pentanoic acid. IEA Catalysis of the reaction: L-arginine = agmatine + CO2. IEA GO:0008792 arginine decarboxylase activity GSVIVG01024167001 644718 647153 GO:0008295 spermidine biosynthetic process The chemical reactions and pathways resulting in the formation of spermidine, N-(3-aminopropyl)-1,4-diaminobutane. IEA Catalysis of the reaction: L-arginine = agmatine + CO2. IEA GO:0008792 arginine decarboxylase activity GSVIVG01034286001 14072231 14075271 GSVIVG01032623001 2113894 2116038 GSVIVG01017202001 5294436 5301677 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01017202001 5294436 5301677 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017202001 5294436 5301677 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01017202001 5294436 5301677 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01027522001 15997963 16002415 GSVIVG01009927001 12465257 12466480 GSVIVG01016514001 3234674 3243227 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). IEA GO:0003755 peptidyl-prolyl cis-trans isomerase activity GSVIVG01016514001 3234674 3243227 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. IEA GO:0016853 isomerase activity GSVIVG01012596001 4491238 4494448 GSVIVG01019657001 2265423 2267057 GSVIVG01032132001 22355860 22359293 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01032132001 22355860 22359293 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01011401001 29357875 29359858 GSVIVG01002028001 32355729 32373409 GO:0006487 protein amino acid N-linked glycosylation A protein amino acid glycosylation process in which a sugar unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan. IEA GO:0000139 Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus. IEA Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + alpha-D-mannosyl-1,3-(R1)-beta-D-mannosyl-R2 = UDP + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(R1)-beta-D-mannosyl-R2. IEA GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity GSVIVG01033508001 20182007 20189157 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01033508001 20182007 20189157 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01033508001 20182007 20189157 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008898001 3244467 3247061 GSVIVG01014313001 2550312 2573720 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01014313001 2550312 2573720 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01007574001 11826629 11853120 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01030716001 14461122 14465888 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030716001 14461122 14465888 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01030716001 14461122 14465888 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01026709001 5289096 5289454 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01026709001 5289096 5289454 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025248001 2726531 2739138 GSVIVG01023303001 19918459 19932528 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01023303001 19918459 19932528 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01023303001 19918459 19932528 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01023303001 19918459 19932528 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01028667001 11869689 11874237 GSVIVG01035935001 6104685 6128186 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01022851001 18769728 18774113 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022851001 18769728 18774113 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036309001 3672151 3676286 GSVIVG01020592001 3967621 3971020 GO:0006519 cellular amino acid and derivative metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01020592001 3967621 3971020 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01020592001 3967621 3971020 GO:0006519 cellular amino acid and derivative metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells. IEA Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. IEA GO:0008483 transaminase activity GSVIVG01020592001 3967621 3971020 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. IEA GO:0008483 transaminase activity GSVIVG01020592001 3967621 3971020 GO:0006519 cellular amino acid and derivative metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells. IEA Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). IEA GO:0016769 transferase activity, transferring nitrogenous groups GSVIVG01020592001 3967621 3971020 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). IEA GO:0016769 transferase activity, transferring nitrogenous groups GSVIVG01020592001 3967621 3971020 GO:0006519 cellular amino acid and derivative metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells. IEA Catalysis of the reaction: S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + methylthioadenosine. IEA GO:0016847 1-aminocyclopropane-1-carboxylate synthase activity GSVIVG01020592001 3967621 3971020 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + methylthioadenosine. IEA GO:0016847 1-aminocyclopropane-1-carboxylate synthase activity GSVIVG01020592001 3967621 3971020 GO:0006519 cellular amino acid and derivative metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01020592001 3967621 3971020 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01029596001 20947176 20948305 GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA GSVIVG01029596001 20947176 20948305 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01028701001 19670039 19676461 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01028701001 19670039 19676461 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028701001 19670039 19676461 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the reaction: ATP + pyruvate = ADP + phosphoenolpyruvate. IEA GO:0004743 pyruvate kinase activity GSVIVG01028701001 19670039 19676461 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Interacting selectively and non-covalently with potassium (K+) ions. IEA GO:0030955 potassium ion binding GSVIVG01019482001 1000293 1003016 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019482001 1000293 1003016 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. IEA GO:0016853 isomerase activity GSVIVG01019482001 1000293 1003016 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01014222001 1636678 1638665 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01014222001 1636678 1638665 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014222001 1636678 1638665 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01014222001 1636678 1638665 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01034963001 483214 487376 GSVIVG01004250001 37640378 37641947 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01004250001 37640378 37641947 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01004250001 37640378 37641947 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01004250001 37640378 37641947 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01030223001 10282228 10283733 Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01020613001 3753289 3765911 GSVIVG01003953001 14012896 14017852 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01005917001 22639541 22641104 GO:0019953 sexual reproduction The regular alternation, in the life cycle of haplontic, diplontic and diplohaplontic organisms, of meiosis and fertilization which provides for the production offspring. In diplontic organisms there is a life cycle in which the products of meiosis behave directly as gametes, fusing to form a zygote from which the diploid, or sexually reproductive polyploid, adult organism will develop. In diplohaplontic organisms a haploid phase (gametophyte) exists in the life cycle between meiosis and fertilization (e.g. higher plants, many algae and Fungi); the products of meiosis are spores that develop as haploid individuals from which haploid gametes develop to form a diploid zygote; diplohaplontic organisms show an alternation of haploid and diploid generations. In haplontic organisms meiosis occurs in the zygote, giving rise to four haploid cells (e.g. many algae and protozoa), only the zygote is diploid and this may form a resistant spore, tiding organisms over hard times. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA GSVIVG01036359001 4194062 4200360 GSVIVG01033012001 25061600 25064939 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. IEA GO:0005179 hormone activity GSVIVG01033012001 25061600 25064939 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. IEA GO:0005179 hormone activity GSVIVG01006166001 42331837 42333769 GO:0006094 gluconeogenesis The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. IEA Catalysis of the reaction: source of phosphate + oxaloacetate = phosphoenolpyruvate + CO2. IEA GO:0004611 phosphoenolpyruvate carboxykinase activity GSVIVG01006166001 42331837 42333769 GO:0006094 gluconeogenesis The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. IEA Catalysis of the reaction: ATP + oxaloacetate = ADP + phosphoenolpyruvate + CO2. IEA GO:0004612 phosphoenolpyruvate carboxykinase (ATP) activity GSVIVG01006166001 42331837 42333769 GO:0006094 gluconeogenesis The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006166001 42331837 42333769 GO:0006094 gluconeogenesis The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. IEA Interacting selectively and non-covalently with purine nucleotides, any compound consisting of a purine nucleoside esterified with (ortho)phosphate. IEA GO:0017076 purine nucleotide binding GSVIVG01012108001 1360444 1369503 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012108001 1360444 1369503 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012108001 1360444 1369503 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01037742001 7430876 7431705 GSVIVG01025161001 3856287 3857940 GSVIVG01032338001 15242961 15243203 GSVIVG01005995001 23165921 23166498 GSVIVG01016158001 20056192 20128267 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016158001 20056192 20128267 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016158001 20056192 20128267 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016158001 20056192 20128267 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016158001 20056192 20128267 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01016158001 20056192 20128267 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01016158001 20056192 20128267 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01016158001 20056192 20128267 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01016158001 20056192 20128267 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016158001 20056192 20128267 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016158001 20056192 20128267 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016158001 20056192 20128267 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016158001 20056192 20128267 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of calcium (Ca) ions from one side of a membrane to the other. IEA GO:0015085 calcium ion transmembrane transporter activity GSVIVG01016158001 20056192 20128267 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of calcium (Ca) ions from one side of a membrane to the other. IEA GO:0015085 calcium ion transmembrane transporter activity GSVIVG01016158001 20056192 20128267 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of calcium (Ca) ions from one side of a membrane to the other. IEA GO:0015085 calcium ion transmembrane transporter activity GSVIVG01016158001 20056192 20128267 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of calcium (Ca) ions from one side of a membrane to the other. IEA GO:0015085 calcium ion transmembrane transporter activity GSVIVG01016158001 20056192 20128267 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01016158001 20056192 20128267 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01016158001 20056192 20128267 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01016158001 20056192 20128267 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01016158001 20056192 20128267 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01016158001 20056192 20128267 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01016158001 20056192 20128267 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01016158001 20056192 20128267 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01019581001 1715552 1732689 GSVIVG01031135001 1836343 1838554 GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA GSVIVG01023873001 2822232 2823699 GSVIVG01023970001 2042274 2050248 GSVIVG01019910001 4402598 4404744 Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01019910001 4402598 4404744 Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01019910001 4402598 4404744 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01019910001 4402598 4404744 Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01005068001 17866321 17868651 GSVIVG01021217001 2635798 2636683 GSVIVG01016326001 5072401 5078465 GSVIVG01004936001 21648793 21648906 GSVIVG01010640001 15687057 15693399 GSVIVG01033572001 19652500 19652886 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033572001 19652500 19652886 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01016304001 5335060 5339133 GO:0008219 cell death A biological process that results in permanent cessation of all vital functions of a cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01027396001 17091676 17093005 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01027396001 17091676 17093005 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01027396001 17091676 17093005 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01027396001 17091676 17093005 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01027396001 17091676 17093005 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01027396001 17091676 17093005 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01027396001 17091676 17093005 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01027396001 17091676 17093005 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01027396001 17091676 17093005 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01027396001 17091676 17093005 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01027396001 17091676 17093005 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01027396001 17091676 17093005 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01027396001 17091676 17093005 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01027396001 17091676 17093005 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01027396001 17091676 17093005 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01024546001 8975439 8978143 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01024546001 8975439 8978143 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01002663001 35757915 35759332 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01023489001 11050207 11051086 GO:0008299 isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. IEA Catalysis of the reaction: acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA. IEA GO:0004421 hydroxymethylglutaryl-CoA synthase activity GSVIVG01031888001 5192902 5194353 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01031888001 5192902 5194353 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01031888001 5192902 5194353 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01031888001 5192902 5194353 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01025438001 802219 803360 GSVIVG01034576001 19179444 19182979 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01034576001 19179444 19182979 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01034576001 19179444 19182979 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli. IEA GO:0004707 MAP kinase activity GSVIVG01034576001 19179444 19182979 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01034576001 19179444 19182979 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025941001 26935654 26938124 GSVIVG01025297001 2352163 2358409 GSVIVG01022198001 17392791 17396253 GSVIVG01008403001 2449848 2450462 GSVIVG01023285001 20121530 20122609 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01023285001 20121530 20122609 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01023285001 20121530 20122609 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01023285001 20121530 20122609 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017920001 4695413 4703395 GSVIVG01012220001 464306 474910 Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum. IEA GO:0003993 acid phosphatase activity GSVIVG01012220001 464306 474910 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01012220001 464306 474910 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01013021001 10099014 10099295 GSVIVG01015379001 3134022 3136172 GSVIVG01009428001 8271909 8274887 GO:0006564 L-serine biosynthetic process The chemical reactions and pathways resulting in the formation of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009428001 8271909 8274887 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009428001 8271909 8274887 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009428001 8271909 8274887 GO:0006564 L-serine biosynthetic process The chemical reactions and pathways resulting in the formation of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. IEA Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+. IEA GO:0004617 phosphoglycerate dehydrogenase activity GSVIVG01009428001 8271909 8274887 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+. IEA GO:0004617 phosphoglycerate dehydrogenase activity GSVIVG01009428001 8271909 8274887 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+. IEA GO:0004617 phosphoglycerate dehydrogenase activity GSVIVG01009428001 8271909 8274887 GO:0006564 L-serine biosynthetic process The chemical reactions and pathways resulting in the formation of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01009428001 8271909 8274887 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01009428001 8271909 8274887 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01009428001 8271909 8274887 GO:0006564 L-serine biosynthetic process The chemical reactions and pathways resulting in the formation of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. IEA Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. IEA GO:0016597 amino acid binding GSVIVG01009428001 8271909 8274887 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. IEA GO:0016597 amino acid binding GSVIVG01009428001 8271909 8274887 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. IEA GO:0016597 amino acid binding GSVIVG01009428001 8271909 8274887 GO:0006564 L-serine biosynthetic process The chemical reactions and pathways resulting in the formation of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01009428001 8271909 8274887 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01009428001 8271909 8274887 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01009428001 8271909 8274887 GO:0006564 L-serine biosynthetic process The chemical reactions and pathways resulting in the formation of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. IEA Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. IEA GO:0048037 cofactor binding GSVIVG01009428001 8271909 8274887 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. IEA GO:0048037 cofactor binding GSVIVG01009428001 8271909 8274887 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. IEA GO:0048037 cofactor binding GSVIVG01009428001 8271909 8274887 GO:0006564 L-serine biosynthetic process The chemical reactions and pathways resulting in the formation of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01009428001 8271909 8274887 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01009428001 8271909 8274887 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01019532001 1390396 1397380 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01019532001 1390396 1397380 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01019532001 1390396 1397380 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01009175001 5751663 5762206 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01030855001 17668398 17669503 GSVIVG01003538001 208744 209388 GSVIVG01032483001 27785086 27788670 GSVIVG01016665001 229605 230432 GSVIVG01023942001 2281236 2297938 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0031227 intrinsic to endoplasmic reticulum membrane Located in the endoplasmic reticulum membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01023942001 2281236 2297938 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0031227 intrinsic to endoplasmic reticulum membrane Located in the endoplasmic reticulum membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01023942001 2281236 2297938 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0031227 intrinsic to endoplasmic reticulum membrane Located in the endoplasmic reticulum membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01019667001 2331027 2335451 GSVIVG01014344001 2834797 2849364 GSVIVG01001524001 995178 997928 GSVIVG01016736001 773125 776455 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016736001 773125 776455 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01007043001 29849613 29853768 GSVIVG01018272001 12223557 12224174 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01018272001 12223557 12224174 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01027067001 18201268 18205274 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027067001 18201268 18205274 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027067001 18201268 18205274 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027067001 18201268 18205274 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027067001 18201268 18205274 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01027067001 18201268 18205274 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01028036001 3338050 3345185 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01028036001 3338050 3345185 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01013638001 2025541 2026268 GSVIVG01009156001 5621304 5622359 GSVIVG01032210001 21506428 21534198 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01032210001 21506428 21534198 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01032210001 21506428 21534198 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032210001 21506428 21534198 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032210001 21506428 21534198 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032210001 21506428 21534198 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032210001 21506428 21534198 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01032210001 21506428 21534198 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01010901001 15969015 15971934 GSVIVG01036274001 7644524 7644697 GSVIVG01031007001 20758279 20758911 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008094001 5833595 5834526 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with manganese (Mn) ions. IEA GO:0030145 manganese ion binding GSVIVG01008094001 5833595 5834526 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Functions in the storage of nutritious substrates. IEA GO:0045735 nutrient reservoir activity GSVIVG01021311001 3844150 3845104 GSVIVG01006454001 26110568 26110932 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01006454001 26110568 26110932 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01006714001 27719406 27731996 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA GSVIVG01025748001 12268045 12271311 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01027538001 15912985 15915649 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027538001 15912985 15915649 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027538001 15912985 15915649 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027538001 15912985 15915649 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027538001 15912985 15915649 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01027538001 15912985 15915649 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01027538001 15912985 15915649 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01027538001 15912985 15915649 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01014634001 8033626 8034820 GSVIVG01003925001 13840934 13847390 GO:0006621 protein retention in ER lumen The retention in the endoplasmic reticulum (ER) lumen of soluble resident proteins. Sorting receptors retrieve proteins with ER localization signals, such as KDEL and HDEL sequences or some transmembrane domains, that have escaped to the cis-Golgi network and return them to the ER. Abnormally folded proteins and unassembled subunits are also selectively retained in the ER. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with an endoplasmic reticulum (ER) retention sequence, a specific peptide sequence that ensures a protein is retained within the ER. IEA GO:0046923 ER retention sequence binding GSVIVG01010358001 19768992 19771314 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018748001 20238997 20242301 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005839 proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. IEA GO:0004175 endopeptidase activity GSVIVG01018748001 20238997 20242301 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0019773 proteasome core complex, alpha-subunit complex The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. IEA GO:0004175 endopeptidase activity GSVIVG01018748001 20238997 20242301 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0005839 proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. IEA GO:0004175 endopeptidase activity GSVIVG01018748001 20238997 20242301 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0019773 proteasome core complex, alpha-subunit complex The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. IEA GO:0004175 endopeptidase activity GSVIVG01018748001 20238997 20242301 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005839 proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. IEA Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. IEA GO:0004298 threonine-type endopeptidase activity GSVIVG01018748001 20238997 20242301 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0019773 proteasome core complex, alpha-subunit complex The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. IEA GO:0004298 threonine-type endopeptidase activity GSVIVG01018748001 20238997 20242301 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0005839 proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. IEA Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. IEA GO:0004298 threonine-type endopeptidase activity GSVIVG01018748001 20238997 20242301 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0019773 proteasome core complex, alpha-subunit complex The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. IEA GO:0004298 threonine-type endopeptidase activity GSVIVG01011078001 1769691 1774118 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01019953001 12438065 12440478 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01019953001 12438065 12440478 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01019953001 12438065 12440478 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01019953001 12438065 12440478 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01016402001 4196563 4199200 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01005122001 18336840 18337700 GSVIVG01007136001 30317508 30320454 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01007136001 30317508 30320454 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01007136001 30317508 30320454 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01007136001 30317508 30320454 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009543001 9220506 9229554 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01009543001 9220506 9229554 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01009543001 9220506 9229554 GO:0009405 pathogenesis The set of specific processes that generate the ability of an organism to cause disease in another. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01009543001 9220506 9229554 GO:0016042 lipid catabolic process The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01011511001 30204261 30208107 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0009317 acetyl-CoA carboxylase complex A protein complex that catalyzes the first step in long-chain fatty acid biosynthesis. For example, in E. coli the complex is heterohexameric and composed of biotin carbonyl carrier protein, biotin carboxylase and the acetate CoA-transferase complex. IEA Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA. IEA GO:0003989 acetyl-CoA carboxylase activity GSVIVG01011511001 30204261 30208107 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0009317 acetyl-CoA carboxylase complex A protein complex that catalyzes the first step in long-chain fatty acid biosynthesis. For example, in E. coli the complex is heterohexameric and composed of biotin carbonyl carrier protein, biotin carboxylase and the acetate CoA-transferase complex. IEA Interacting selectively and non-covalently with biotin (cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid), the (+) enantiomer of which is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions. IEA GO:0009374 biotin binding GSVIVG01029457001 22645064 22648842 GSVIVG01027019001 18536966 18541123 GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA GSVIVG01007998001 6799123 6802702 GSVIVG01001124001 22826373 22828816 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01001124001 22826373 22828816 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01001124001 22826373 22828816 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01001124001 22826373 22828816 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01001124001 22826373 22828816 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01001124001 22826373 22828816 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01001124001 22826373 22828816 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01001124001 22826373 22828816 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01026598001 21199523 21230747 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01024105001 1015314 1019861 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018972001 18219167 18219838 GSVIVG01031066001 21747481 21749101 GSVIVG01026644001 20787048 20791102 GSVIVG01023026001 16711833 16720870 GSVIVG01013614001 1516503 1583602 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01013614001 1516503 1583602 GO:0007031 peroxisome organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules. IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01013614001 1516503 1583602 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01013614001 1516503 1583602 GO:0007031 peroxisome organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules. IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01013614001 1516503 1583602 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013614001 1516503 1583602 GO:0007031 peroxisome organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules. IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013614001 1516503 1583602 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013614001 1516503 1583602 GO:0007031 peroxisome organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules. IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013614001 1516503 1583602 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01013614001 1516503 1583602 GO:0007031 peroxisome organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules. IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01003565001 14696279 14699748 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01003565001 14696279 14699748 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01003565001 14696279 14699748 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003565001 14696279 14699748 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003565001 14696279 14699748 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01003565001 14696279 14699748 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01022996001 17159256 17165529 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01022996001 17159256 17165529 GO:0006419 alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01022996001 17159256 17165529 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala). IEA GO:0004813 alanine-tRNA ligase activity GSVIVG01022996001 17159256 17165529 GO:0006419 alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala). IEA GO:0004813 alanine-tRNA ligase activity GSVIVG01022996001 17159256 17165529 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022996001 17159256 17165529 GO:0006419 alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035296001 166624 170092 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01035296001 166624 170092 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01022140001 16903701 16909303 GSVIVG01034748001 8897703 8904965 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01034748001 8897703 8904965 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01034748001 8897703 8904965 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01034748001 8897703 8904965 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034748001 8897703 8904965 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01034748001 8897703 8904965 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01022487001 3697967 3698173 GSVIVG01016305001 5322567 5324692 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01035382001 912018 914578 GSVIVG01025566001 14006855 14009864 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. IEA GO:0004364 glutathione transferase activity GSVIVG01025863001 11077948 11086760 GSVIVG01001348001 23849818 23858303 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01001348001 23849818 23858303 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01001348001 23849818 23858303 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001348001 23849818 23858303 Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01010583001 16349844 16351505 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010583001 16349844 16351505 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010583001 16349844 16351505 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01010583001 16349844 16351505 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01009293001 7050228 7052300 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01009293001 7050228 7052300 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01023274001 20249550 20254467 GO:0016226 iron-sulfur cluster assembly The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01023274001 20249550 20254467 GO:0016226 iron-sulfur cluster assembly The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01010819001 22996375 23004692 GSVIVG01035731001 3767960 3777658 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01021008001 15437399 15444641 GSVIVG01022804001 16785801 16791758 Interacting selectively and non-covalently with acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group. IEA GO:0000062 acyl-CoA binding GSVIVG01022804001 16785801 16791758 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01018739001 20288224 20291182 GSVIVG01035399001 1010389 1016584 GSVIVG01006715001 27738825 27740811 GSVIVG01026966001 18954067 18956784 GSVIVG01015609001 14033505 14034062 GSVIVG01037728001 7292441 7293275 GSVIVG01035486001 1690953 1693342 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01035486001 1690953 1693342 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01035486001 1690953 1693342 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01035486001 1690953 1693342 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019608001 1905457 1914484 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA Catalysis of the reaction: ATP + deamido-NAD+ + L-glutamine + H2O = AMP + diphosphate + NAD+ + L-glutamate. IEA GO:0003952 NAD+ synthase (glutamine-hydrolyzing) activity GSVIVG01019608001 1905457 1914484 GO:0009435 NAD biosynthetic process The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH. IEA Catalysis of the reaction: ATP + deamido-NAD+ + L-glutamine + H2O = AMP + diphosphate + NAD+ + L-glutamate. IEA GO:0003952 NAD+ synthase (glutamine-hydrolyzing) activity GSVIVG01019608001 1905457 1914484 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019608001 1905457 1914484 GO:0009435 NAD biosynthetic process The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019608001 1905457 1914484 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. IEA GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GSVIVG01019608001 1905457 1914484 GO:0009435 NAD biosynthetic process The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH. IEA Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. IEA GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GSVIVG01008518001 1164924 1190012 GSVIVG01003867001 8984 12076 GO:0006452 translational frameshifting A mechanism whereby different proteins may result from a single mRNA molecule, due to a change in the parsing of three nucleotides per codon relative to an initiating AUG codon. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01003867001 8984 12076 GO:0008612 peptidyl-lysine modification to hypusine The posttranslational modification of peptidyl-lysine to form hypusine, N6-(4-amino-2-hydroxybutyl)-L-lysine. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01003867001 8984 12076 GO:0045901 positive regulation of translational elongation Any process that activates or increases the frequency, rate or extent of translational elongation. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01003867001 8984 12076 GO:0045905 positive regulation of translational termination Any process that activates or increases the frequency, rate or extent of translational termination. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01003867001 8984 12076 GO:0006452 translational frameshifting A mechanism whereby different proteins may result from a single mRNA molecule, due to a change in the parsing of three nucleotides per codon relative to an initiating AUG codon. IEA Functions in chain elongation during polypeptide synthesis at the ribosome. IEA GO:0003746 translation elongation factor activity GSVIVG01003867001 8984 12076 GO:0008612 peptidyl-lysine modification to hypusine The posttranslational modification of peptidyl-lysine to form hypusine, N6-(4-amino-2-hydroxybutyl)-L-lysine. IEA Functions in chain elongation during polypeptide synthesis at the ribosome. IEA GO:0003746 translation elongation factor activity GSVIVG01003867001 8984 12076 GO:0045901 positive regulation of translational elongation Any process that activates or increases the frequency, rate or extent of translational elongation. IEA Functions in chain elongation during polypeptide synthesis at the ribosome. IEA GO:0003746 translation elongation factor activity GSVIVG01003867001 8984 12076 GO:0045905 positive regulation of translational termination Any process that activates or increases the frequency, rate or extent of translational termination. IEA Functions in chain elongation during polypeptide synthesis at the ribosome. IEA GO:0003746 translation elongation factor activity GSVIVG01003867001 8984 12076 GO:0006452 translational frameshifting A mechanism whereby different proteins may result from a single mRNA molecule, due to a change in the parsing of three nucleotides per codon relative to an initiating AUG codon. IEA Interacting selectively and non-covalently with any part of a ribosome. IEA GO:0043022 ribosome binding GSVIVG01003867001 8984 12076 GO:0008612 peptidyl-lysine modification to hypusine The posttranslational modification of peptidyl-lysine to form hypusine, N6-(4-amino-2-hydroxybutyl)-L-lysine. IEA Interacting selectively and non-covalently with any part of a ribosome. IEA GO:0043022 ribosome binding GSVIVG01003867001 8984 12076 GO:0045901 positive regulation of translational elongation Any process that activates or increases the frequency, rate or extent of translational elongation. IEA Interacting selectively and non-covalently with any part of a ribosome. IEA GO:0043022 ribosome binding GSVIVG01003867001 8984 12076 GO:0045905 positive regulation of translational termination Any process that activates or increases the frequency, rate or extent of translational termination. IEA Interacting selectively and non-covalently with any part of a ribosome. IEA GO:0043022 ribosome binding GSVIVG01026168001 13323696 13325248 GSVIVG01002447001 34773498 34774970 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01002447001 34773498 34774970 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01002447001 34773498 34774970 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01002447001 34773498 34774970 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01002447001 34773498 34774970 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01002447001 34773498 34774970 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01002447001 34773498 34774970 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01002447001 34773498 34774970 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01021046001 14756067 14759491 GO:0006544 glycine metabolic process The chemical reactions and pathways involving glycine, aminoethanoic acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021046001 14756067 14759491 GO:0006563 L-serine metabolic process The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021046001 14756067 14759491 GO:0006544 glycine metabolic process The chemical reactions and pathways involving glycine, aminoethanoic acid. IEA Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine. IEA GO:0004372 glycine hydroxymethyltransferase activity GSVIVG01021046001 14756067 14759491 GO:0006563 L-serine metabolic process The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. IEA Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine. IEA GO:0004372 glycine hydroxymethyltransferase activity GSVIVG01021046001 14756067 14759491 GO:0006544 glycine metabolic process The chemical reactions and pathways involving glycine, aminoethanoic acid. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01021046001 14756067 14759491 GO:0006563 L-serine metabolic process The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01035871001 5088359 5092071 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032853001 236542 242160 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01020172001 9449744 9452855 GSVIVG01032519001 28045454 28048057 GSVIVG01012207001 563211 566736 Interacting selectively and non-covalently with a specific domain of a protein. IEA GO:0019904 protein domain specific binding GSVIVG01037147001 28627961 28629416 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01037147001 28627961 28629416 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). IEA GO:0016769 transferase activity, transferring nitrogenous groups GSVIVG01037147001 28627961 28629416 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01037562001 11385541 11387097 GSVIVG01035967001 6600137 6607636 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024908001 6115575 6116219 GSVIVG01003119001 7431370 7437119 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01017817001 3702252 3705298 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Enables the directed movement of acyl groups into, out of, within or between cells. IEA GO:0000036 acyl carrier activity GSVIVG01017817001 3702252 3705298 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Interacting selectizely with phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate). IEA GO:0031177 phosphopantetheine binding GSVIVG01017817001 3702252 3705298 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. IEA GO:0048037 cofactor binding GSVIVG01000573001 6955274 6958016 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000573001 6955274 6958016 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01000573001 6955274 6958016 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01001065001 7216453 7216695 GSVIVG01023143001 22037031 22079478 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01034150001 14814541 14818484 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01034150001 14814541 14818484 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010187001 16970765 16987400 GSVIVG01030218001 10345520 10349607 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030218001 10345520 10349607 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030218001 10345520 10349607 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. IEA GO:0008483 transaminase activity GSVIVG01030218001 10345520 10349607 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. IEA GO:0008483 transaminase activity GSVIVG01030218001 10345520 10349607 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). IEA GO:0016769 transferase activity, transferring nitrogenous groups GSVIVG01030218001 10345520 10349607 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). IEA GO:0016769 transferase activity, transferring nitrogenous groups GSVIVG01030218001 10345520 10349607 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01030218001 10345520 10349607 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01019806001 3488173 3496025 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01000301001 2703199 2703939 GSVIVG01016865001 2085471 2101639 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0009341 beta-galactosidase complex A multimeric enzyme complex that in E. coli is a heterooctamer made up of four alpha subunits and four beta subunits. Catalyzes the hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016865001 2085471 2101639 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0009341 beta-galactosidase complex A multimeric enzyme complex that in E. coli is a heterooctamer made up of four alpha subunits and four beta subunits. Catalyzes the hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01016865001 2085471 2101639 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0009341 beta-galactosidase complex A multimeric enzyme complex that in E. coli is a heterooctamer made up of four alpha subunits and four beta subunits. Catalyzes the hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides. IEA Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides. IEA GO:0004565 beta-galactosidase activity GSVIVG01016865001 2085471 2101639 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0009341 beta-galactosidase complex A multimeric enzyme complex that in E. coli is a heterooctamer made up of four alpha subunits and four beta subunits. Catalyzes the hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01035925001 5980584 5997956 GSVIVG01018425001 9154901 9156538 GSVIVG01016348001 4746010 4752139 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01034787001 21636039 21636242 GSVIVG01027784001 7697515 7698248 GSVIVG01011015001 2195189 2198271 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA GSVIVG01020855001 975636 984141 GSVIVG01031220001 1070765 1076734 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01031220001 1070765 1076734 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01026068001 25007145 25023035 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01008221001 4510755 4521210 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01038751001 465826 467195 GSVIVG01031286001 613453 616484 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01031286001 613453 616484 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031286001 613453 616484 Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01031286001 613453 616484 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01018984001 18074949 18081203 GO:0001503 ossification The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018984001 18074949 18081203 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014999001 308011 311935 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the reaction: pectin + n H2O = n methanol + pectate. IEA GO:0030599 pectinesterase activity GSVIVG01038782001 874496 877736 GO:0006481 C-terminal protein amino acid methylation The methylation of the C-terminal amino acid of a protein. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester. IEA GO:0004671 protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity GSVIVG01019942001 4642112 4643844 GSVIVG01029290001 17451588 17454789 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01029290001 17451588 17454789 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01029290001 17451588 17454789 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029290001 17451588 17454789 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029290001 17451588 17454789 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029290001 17451588 17454789 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029290001 17451588 17454789 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01029290001 17451588 17454789 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01036131001 20330315 20344457 GSVIVG01017970001 5165690 5166307 GSVIVG01008574001 769342 770298 GSVIVG01011922001 2981221 2996482 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01011922001 2981221 2996482 Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01034953001 401103 404183 GSVIVG01031881001 5114314 5120632 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01031881001 5114314 5120632 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01031881001 5114314 5120632 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01031881001 5114314 5120632 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01031881001 5114314 5120632 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate. IEA GO:0019001 guanyl nucleotide binding GSVIVG01031881001 5114314 5120632 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate. IEA GO:0019001 guanyl nucleotide binding GSVIVG01027597001 15176861 15179428 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01027597001 15176861 15179428 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01027597001 15176861 15179428 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01027597001 15176861 15179428 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01030650001 7495126 7500348 GSVIVG01021353001 4361857 4373894 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01011898001 3180008 3185822 GSVIVG01017699001 2749340 2750998 GSVIVG01020070001 10815152 10819031 GO:0006820 anion transport The directed movement of anions, atoms or small molecules with a net negative charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005741 mitochondrial outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope. IEA Catalysis of the transmembrane transfer of an anion by a voltage-gated channel. An anion is a negatively charged ion. IEA GO:0008308 voltage-gated anion channel activity GSVIVG01020070001 10815152 10819031 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005741 mitochondrial outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope. IEA Catalysis of the transmembrane transfer of an anion by a voltage-gated channel. An anion is a negatively charged ion. IEA GO:0008308 voltage-gated anion channel activity GSVIVG01014009001 8904450 8905485 GSVIVG01018666001 11479681 11480701 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005875 microtubule associated complex Any multimeric complex connected to a microtubule. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01005258001 19939559 19940740 GSVIVG01025616001 13548849 13554558 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01023973001 2018526 2021184 GO:0006605 protein targeting The process of targeting specific proteins to particular membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01023973001 2018526 2021184 GO:0006605 protein targeting The process of targeting specific proteins to particular membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01023973001 2018526 2021184 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01023973001 2018526 2021184 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01023973001 2018526 2021184 GO:0009306 protein secretion The controlled release of proteins from a cell or group of cells. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01023973001 2018526 2021184 GO:0009306 protein secretion The controlled release of proteins from a cell or group of cells. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01018045001 5772786 5779425 Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01001741001 715013 715346 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01016645001 11368 16751 GSVIVG01007425001 31757769 31761924 GSVIVG01005385001 40047068 40051081 GSVIVG01003688001 12187434 12233883 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01003688001 12187434 12233883 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01003688001 12187434 12233883 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. IEA GO:0008173 RNA methyltransferase activity GSVIVG01035957001 6448229 6495905 GO:0016043 cellular component organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cellular component. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01035957001 6448229 6495905 GO:0030036 actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01029318001 16935079 16938280 GSVIVG01014579001 5339584 5342567 GSVIVG01027287001 17156924 17164533 GSVIVG01008876001 2960194 3039077 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01022517001 4262189 4263377 GSVIVG01014559001 5167089 5172317 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and carries out proton transport across a membrane. The proton-transporting domain (F0, V0, or A0) includes integral and peripheral membrane proteins. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01026097001 24598423 24599846 GSVIVG01032498001 27914702 27919086 GSVIVG01033442001 20649232 20658009 GSVIVG01016461001 3681072 3688556 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01029385001 15973976 15974229 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01005262001 19973084 19977312 GSVIVG01009215001 6286736 6292127 Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01008536001 1023042 1025124 GSVIVG01030787001 16137464 16138807 GSVIVG01010022001 13526074 13535704 GO:0006357 regulation of transcription from RNA polymerase II promoter Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule following transcription initiation. IEA GO:0003711 transcription elongation regulator activity GSVIVG01010022001 13526074 13535704 GO:0006357 regulation of transcription from RNA polymerase II promoter Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule following transcription initiation. IEA GO:0003711 transcription elongation regulator activity GSVIVG01010022001 13526074 13535704 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule following transcription initiation. IEA GO:0003711 transcription elongation regulator activity GSVIVG01010022001 13526074 13535704 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule following transcription initiation. IEA GO:0003711 transcription elongation regulator activity GSVIVG01010022001 13526074 13535704 GO:0032968 positive regulation of RNA elongation from RNA polymerase II promoter Any process that activates or increases the frequency, rate or extent of RNA elongation, the extension of an RNA molecule after transcription initiation by the addition of ribonucleotides, catalyzed by RNA polymerase II. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule following transcription initiation. IEA GO:0003711 transcription elongation regulator activity GSVIVG01010022001 13526074 13535704 GO:0032968 positive regulation of RNA elongation from RNA polymerase II promoter Any process that activates or increases the frequency, rate or extent of RNA elongation, the extension of an RNA molecule after transcription initiation by the addition of ribonucleotides, catalyzed by RNA polymerase II. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule following transcription initiation. IEA GO:0003711 transcription elongation regulator activity GSVIVG01010022001 13526074 13535704 GO:0006357 regulation of transcription from RNA polymerase II promoter Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01010022001 13526074 13535704 GO:0006357 regulation of transcription from RNA polymerase II promoter Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01010022001 13526074 13535704 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01010022001 13526074 13535704 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01010022001 13526074 13535704 GO:0032968 positive regulation of RNA elongation from RNA polymerase II promoter Any process that activates or increases the frequency, rate or extent of RNA elongation, the extension of an RNA molecule after transcription initiation by the addition of ribonucleotides, catalyzed by RNA polymerase II. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01010022001 13526074 13535704 GO:0032968 positive regulation of RNA elongation from RNA polymerase II promoter Any process that activates or increases the frequency, rate or extent of RNA elongation, the extension of an RNA molecule after transcription initiation by the addition of ribonucleotides, catalyzed by RNA polymerase II. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01029998001 8819568 8830537 GSVIVG01007481001 32187185 32190760 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01007481001 32187185 32190760 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01007481001 32187185 32190760 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01007481001 32187185 32190760 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01007481001 32187185 32190760 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01007481001 32187185 32190760 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01007481001 32187185 32190760 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01007481001 32187185 32190760 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01007481001 32187185 32190760 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01007481001 32187185 32190760 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01007481001 32187185 32190760 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01007481001 32187185 32190760 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01007481001 32187185 32190760 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01007481001 32187185 32190760 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01007481001 32187185 32190760 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01007481001 32187185 32190760 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01007481001 32187185 32190760 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a carboxyl group (acceptor). IEA GO:0016774 phosphotransferase activity, carboxyl group as acceptor GSVIVG01007481001 32187185 32190760 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a carboxyl group (acceptor). IEA GO:0016774 phosphotransferase activity, carboxyl group as acceptor GSVIVG01007481001 32187185 32190760 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a carboxyl group (acceptor). IEA GO:0016774 phosphotransferase activity, carboxyl group as acceptor GSVIVG01007481001 32187185 32190760 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a carboxyl group (acceptor). IEA GO:0016774 phosphotransferase activity, carboxyl group as acceptor GSVIVG01007481001 32187185 32190760 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a carboxyl group (acceptor). IEA GO:0016774 phosphotransferase activity, carboxyl group as acceptor GSVIVG01007481001 32187185 32190760 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a carboxyl group (acceptor). IEA GO:0016774 phosphotransferase activity, carboxyl group as acceptor GSVIVG01007481001 32187185 32190760 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a carboxyl group (acceptor). IEA GO:0016774 phosphotransferase activity, carboxyl group as acceptor GSVIVG01007481001 32187185 32190760 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a carboxyl group (acceptor). IEA GO:0016774 phosphotransferase activity, carboxyl group as acceptor GSVIVG01026290001 12779377 12797933 GSVIVG01014001001 8729918 8731307 GSVIVG01008116001 5652105 5658572 GSVIVG01032759001 963626 968233 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01009190001 5930197 5932891 GO:0018346 protein amino acid prenylation The covalent attachment of a prenyl moiety to a protein amino acid. IEA Catalysis of the covalent addition of an isoprenoid group such as a farnesyl or geranylgeranyl group via thioether linkages to a cysteine residue in a protein. IEA GO:0008318 protein prenyltransferase activity GSVIVG01026317001 13618566 13620032 GSVIVG01022389001 19551754 19559508 GSVIVG01032270001 14311347 14323145 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0016272 prefoldin complex A multisubunit chaperone that acts to delivers unfolded proteins to cytosolic chaperonin. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01030528001 6491575 6511613 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01030528001 6491575 6511613 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01003632001 545271 555531 GSVIVG01019596001 1831755 1832406 GSVIVG01027882001 8963423 8963617 GSVIVG01023354001 19403336 19404922 GO:0009306 protein secretion The controlled release of proteins from a cell or group of cells. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01032170001 21853187 21854918 GSVIVG01027965001 2859283 2860867 GO:0015937 coenzyme A biosynthetic process The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. IEA Catalysis of the reaction: ATP + dephospho-CoA = ADP + CoA. IEA GO:0004140 dephospho-CoA kinase activity GSVIVG01027965001 2859283 2860867 GO:0015937 coenzyme A biosynthetic process The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027965001 2859283 2860867 GO:0015937 coenzyme A biosynthetic process The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01008590001 588540 591995 GSVIVG01032984001 24820195 24822192 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. IEA GO:0008080 N-acetyltransferase activity GSVIVG01013090001 8417888 8435103 Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor. IEA GO:0003950 NAD+ ADP-ribosyltransferase activity GSVIVG01013506001 1967136 1968407 GSVIVG01020219001 8922597 8933413 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of potassium ions (K+) from one side of a membrane to the other. IEA GO:0015079 potassium ion transmembrane transporter activity GSVIVG01011508001 30165022 30170199 GSVIVG01015302001 2501605 2503392 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01015302001 2501605 2503392 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01015302001 2501605 2503392 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. IEA GO:0008173 RNA methyltransferase activity GSVIVG01009074001 4733208 4737587 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01009074001 4733208 4737587 GO:0006970 response to osmotic stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01009074001 4733208 4737587 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01009074001 4733208 4737587 GO:0006970 response to osmotic stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01009074001 4733208 4737587 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01009074001 4733208 4737587 GO:0006970 response to osmotic stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01009074001 4733208 4737587 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009074001 4733208 4737587 GO:0006970 response to osmotic stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009074001 4733208 4737587 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01009074001 4733208 4737587 GO:0006970 response to osmotic stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01021968001 4971713 4977300 GSVIVG01007896001 7802416 7816859 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01016940001 2782693 2799564 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01024602001 8523708 8524399 GSVIVG01018271001 12230432 12231049 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01018271001 12230432 12231049 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01025827001 11436840 11452917 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01025827001 11436840 11452917 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01025827001 11436840 11452917 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01023202001 21194934 21195943 GSVIVG01019012001 17798124 17799885 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019012001 17798124 17799885 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019012001 17798124 17799885 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01019012001 17798124 17799885 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01019012001 17798124 17799885 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01019012001 17798124 17799885 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01019012001 17798124 17799885 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01019012001 17798124 17799885 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01019811001 3513811 3521744 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019811001 3513811 3521744 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01019811001 3513811 3521744 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01019811001 3513811 3521744 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01019811001 3513811 3521744 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01021145001 1814031 1815853 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01021145001 1814031 1815853 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01021145001 1814031 1815853 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01021145001 1814031 1815853 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01021145001 1814031 1815853 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01021145001 1814031 1815853 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01021145001 1814031 1815853 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01021145001 1814031 1815853 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01021145001 1814031 1815853 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01021145001 1814031 1815853 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01021145001 1814031 1815853 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01021145001 1814031 1815853 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01021145001 1814031 1815853 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01021145001 1814031 1815853 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01021145001 1814031 1815853 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01007572001 11856663 11860209 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007572001 11856663 11860209 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01008637001 232691 236378 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01015501001 4261204 4267072 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01015501001 4261204 4267072 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01018759001 20125965 20126809 GSVIVG01011775001 4265497 4268723 GSVIVG01035677001 3228995 3231532 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01035677001 3228995 3231532 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01022199001 17402782 17404909 GSVIVG01003793001 12773760 12774458 GSVIVG01030194001 10650328 10661181 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01030194001 10650328 10661181 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01030194001 10650328 10661181 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01030194001 10650328 10661181 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013292001 76664 77919 GSVIVG01037826001 7428322 7430945 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01037826001 7428322 7430945 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01027129001 17594059 17600159 GSVIVG01022812001 16900112 16901615 GO:0007585 respiratory gaseous exchange The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. IEA GO:0005740 mitochondrial envelope The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01022812001 16900112 16901615 GO:0007585 respiratory gaseous exchange The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01022812001 16900112 16901615 GO:0007585 respiratory gaseous exchange The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01022812001 16900112 16901615 GO:0007585 respiratory gaseous exchange The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. IEA GO:0070469 respiratory chain The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01022812001 16900112 16901615 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0005740 mitochondrial envelope The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01022812001 16900112 16901615 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01022812001 16900112 16901615 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01022812001 16900112 16901615 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0070469 respiratory chain The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01022812001 16900112 16901615 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005740 mitochondrial envelope The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01022812001 16900112 16901615 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01022812001 16900112 16901615 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01022812001 16900112 16901615 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0070469 respiratory chain The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01022812001 16900112 16901615 GO:0007585 respiratory gaseous exchange The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. IEA GO:0005740 mitochondrial envelope The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022812001 16900112 16901615 GO:0007585 respiratory gaseous exchange The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022812001 16900112 16901615 GO:0007585 respiratory gaseous exchange The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022812001 16900112 16901615 GO:0007585 respiratory gaseous exchange The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. IEA GO:0070469 respiratory chain The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022812001 16900112 16901615 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0005740 mitochondrial envelope The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022812001 16900112 16901615 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022812001 16900112 16901615 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022812001 16900112 16901615 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0070469 respiratory chain The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022812001 16900112 16901615 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005740 mitochondrial envelope The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022812001 16900112 16901615 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022812001 16900112 16901615 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022812001 16900112 16901615 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0070469 respiratory chain The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022812001 16900112 16901615 GO:0007585 respiratory gaseous exchange The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. IEA GO:0005740 mitochondrial envelope The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01022812001 16900112 16901615 GO:0007585 respiratory gaseous exchange The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01022812001 16900112 16901615 GO:0007585 respiratory gaseous exchange The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01022812001 16900112 16901615 GO:0007585 respiratory gaseous exchange The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. IEA GO:0070469 respiratory chain The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01022812001 16900112 16901615 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0005740 mitochondrial envelope The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01022812001 16900112 16901615 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01022812001 16900112 16901615 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01022812001 16900112 16901615 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0070469 respiratory chain The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01022812001 16900112 16901615 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005740 mitochondrial envelope The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01022812001 16900112 16901615 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01022812001 16900112 16901615 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01022812001 16900112 16901615 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0070469 respiratory chain The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01005492001 40459602 40461113 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals. IEA GO:0008519 ammonium transmembrane transporter activity GSVIVG01005492001 40459602 40461113 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals. IEA GO:0008519 ammonium transmembrane transporter activity GSVIVG01005492001 40459602 40461113 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals. IEA GO:0008519 ammonium transmembrane transporter activity GSVIVG01005492001 40459602 40461113 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals. IEA GO:0008519 ammonium transmembrane transporter activity GSVIVG01032366001 26750259 26757263 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01032366001 26750259 26757263 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01032366001 26750259 26757263 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01032366001 26750259 26757263 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01032366001 26750259 26757263 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01032366001 26750259 26757263 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032366001 26750259 26757263 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032366001 26750259 26757263 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032366001 26750259 26757263 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032366001 26750259 26757263 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032366001 26750259 26757263 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01032366001 26750259 26757263 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01032366001 26750259 26757263 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01032366001 26750259 26757263 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01032366001 26750259 26757263 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01036446001 22042736 22046642 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01022139001 16891871 16901853 GSVIVG01001640001 21672930 21673568 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01001640001 21672930 21673568 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01034553001 19559680 19564675 GSVIVG01009048001 4544137 4544831 GSVIVG01028459001 7912161 7916627 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01028459001 7912161 7916627 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028459001 7912161 7916627 Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01028459001 7912161 7916627 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01018278001 12130592 12138792 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01018278001 12130592 12138792 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01018278001 12130592 12138792 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01018278001 12130592 12138792 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036100001 20716998 20718732 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01036100001 20716998 20718732 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01036100001 20716998 20718732 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01036100001 20716998 20718732 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01036100001 20716998 20718732 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01036100001 20716998 20718732 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01036100001 20716998 20718732 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01036100001 20716998 20718732 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01036100001 20716998 20718732 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01036100001 20716998 20718732 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01004476001 38788776 38791640 GSVIVG01001361001 23971224 23998913 GO:0006075 1,3-beta-glucan biosynthetic process The chemical reactions and pathways resulting in the formation of beta-1,3 glucans, compounds composed of glucose residues linked by 1,3-beta-D-glucosidic bonds. IEA GO:0000148 1,3-beta-glucan synthase complex A protein complex that catalyzes the transfer of a glucose moiety from UDP-glucose to a 1,3-beta-D-glucan chain. IEA Catalysis of the reaction: UDP-glucose + 1,3-beta-D-glucosyl(n) = UDP + 1,3-beta-D-glucosyl(n+1). IEA GO:0003843 1,3-beta-glucan synthase activity GSVIVG01001361001 23971224 23998913 GO:0006075 1,3-beta-glucan biosynthetic process The chemical reactions and pathways resulting in the formation of beta-1,3 glucans, compounds composed of glucose residues linked by 1,3-beta-D-glucosidic bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: UDP-glucose + 1,3-beta-D-glucosyl(n) = UDP + 1,3-beta-D-glucosyl(n+1). IEA GO:0003843 1,3-beta-glucan synthase activity GSVIVG01016915001 2510633 2515605 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01016915001 2510633 2515605 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01016915001 2510633 2515605 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01016915001 2510633 2515605 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016915001 2510633 2515605 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032850001 263305 269179 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01032850001 263305 269179 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01032850001 263305 269179 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032850001 263305 269179 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032850001 263305 269179 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032850001 263305 269179 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032850001 263305 269179 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01032850001 263305 269179 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01032850001 263305 269179 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01032850001 263305 269179 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01032424001 27277237 27282510 GSVIVG01025665001 13099259 13106608 GSVIVG01013856001 5357259 5358151 GO:0015977 carbon fixation A metabolic process in which carbon (usually derived from carbon dioxide) is incorporated into organic compounds (usually carbohydrates). IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01013856001 5357259 5358151 GO:0015977 carbon fixation A metabolic process in which carbon (usually derived from carbon dioxide) is incorporated into organic compounds (usually carbohydrates). IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Catalysis of the reaction: D-ribulose 1,5-bisphosphate + CO2 + H2O = 2 3-phospho-D-glycerate. IEA GO:0016984 ribulose-bisphosphate carboxylase activity GSVIVG01008807001 2298828 2303531 GSVIVG01032120001 22480789 22496776 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01005822001 22122192 22123929 GSVIVG01001439001 21012598 21020589 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01035450001 1355371 1359837 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01014749001 9180442 9187446 GSVIVG01038339001 13244915 13251598 GSVIVG01027534001 15946954 15948435 GSVIVG01002632001 35515455 35518041 GSVIVG01007167001 30616411 30623911 GSVIVG01028777001 18945412 18951829 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033182001 9132360 9153875 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01033182001 9132360 9153875 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01016741001 845751 847480 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01016741001 845751 847480 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01016741001 845751 847480 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01016741001 845751 847480 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006613001 27042547 27044548 GSVIVG01018478001 14544699 14545650 GSVIVG01017125001 4405820 4406667 GSVIVG01012102001 1466985 1495349 GSVIVG01034205001 14439485 14447364 GSVIVG01018544001 13606007 13606881 GO:0006725 cellular aromatic compound metabolic process The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells. IEA Interacting selectively and non-covalently with ferrous iron, Fe(II). IEA GO:0008198 ferrous iron binding GSVIVG01018544001 13606007 13606881 GO:0006725 cellular aromatic compound metabolic process The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001080001 22452109 22456182 GSVIVG01003965001 26344028 26355087 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01003965001 26344028 26355087 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01010869001 16641176 16648979 GSVIVG01013347001 12498442 12502752 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01035279001 11908473 11909516 GSVIVG01032062001 23105949 23111224 GSVIVG01036312001 3693107 3701123 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01036312001 3693107 3701123 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01016594001 2545740 2550226 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01015888001 18962367 18963418 GSVIVG01037652001 6574167 6579250 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01037652001 6574167 6579250 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01037652001 6574167 6579250 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01037652001 6574167 6579250 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01037652001 6574167 6579250 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035464001 1467631 1468488 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01021592001 7677854 7690318 GSVIVG01035352001 695313 698914 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) All non-F1 subunits of the mitochondrial hydrogen-transporting ATP synthase, including integral and peripheral mitochondrial inner membrane proteins. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01034370001 17288935 17308258 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01034370001 17288935 17308258 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01034370001 17288935 17308258 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01034370001 17288935 17308258 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01034370001 17288935 17308258 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034370001 17288935 17308258 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01013741001 8004150 8007646 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01013741001 8004150 8007646 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01013741001 8004150 8007646 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01013741001 8004150 8007646 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01013741001 8004150 8007646 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01013741001 8004150 8007646 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01013741001 8004150 8007646 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01013741001 8004150 8007646 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01013741001 8004150 8007646 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01013741001 8004150 8007646 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01013741001 8004150 8007646 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01013741001 8004150 8007646 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01013741001 8004150 8007646 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01013741001 8004150 8007646 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01013741001 8004150 8007646 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01013741001 8004150 8007646 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01013741001 8004150 8007646 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01013741001 8004150 8007646 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01013741001 8004150 8007646 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01013741001 8004150 8007646 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01013741001 8004150 8007646 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01013741001 8004150 8007646 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01013741001 8004150 8007646 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01013741001 8004150 8007646 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01013741001 8004150 8007646 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA The action of a molecule that contributes to the structural integrity of a cell wall. IEA GO:0005199 structural constituent of cell wall GSVIVG01013741001 8004150 8007646 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The action of a molecule that contributes to the structural integrity of a cell wall. IEA GO:0005199 structural constituent of cell wall GSVIVG01013741001 8004150 8007646 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA The action of a molecule that contributes to the structural integrity of a cell wall. IEA GO:0005199 structural constituent of cell wall GSVIVG01013741001 8004150 8007646 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The action of a molecule that contributes to the structural integrity of a cell wall. IEA GO:0005199 structural constituent of cell wall GSVIVG01013741001 8004150 8007646 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA The action of a molecule that contributes to the structural integrity of a cell wall. IEA GO:0005199 structural constituent of cell wall GSVIVG01013741001 8004150 8007646 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The action of a molecule that contributes to the structural integrity of a cell wall. IEA GO:0005199 structural constituent of cell wall GSVIVG01013741001 8004150 8007646 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013741001 8004150 8007646 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013741001 8004150 8007646 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013741001 8004150 8007646 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013741001 8004150 8007646 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013741001 8004150 8007646 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007627001 11111214 11112253 GSVIVG01026105001 24519409 24521612 GSVIVG01034683001 7593572 7598153 GSVIVG01013446001 399144 410940 GSVIVG01008620001 344953 353431 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008620001 344953 353431 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008620001 344953 353431 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01008620001 344953 353431 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01008620001 344953 353431 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008620001 344953 353431 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008620001 344953 353431 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008620001 344953 353431 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01030799001 16253033 16255585 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01010012001 13444644 13445959 GO:0006662 glycerol ether metabolic process The chemical reactions and pathways involving glycerol ethers, any anhydride formed between two organic hydroxy compounds, one of which is glycerol. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01010012001 13444644 13445959 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01010012001 13444644 13445959 GO:0006662 glycerol ether metabolic process The chemical reactions and pathways involving glycerol ethers, any anhydride formed between two organic hydroxy compounds, one of which is glycerol. IEA Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds. IEA GO:0015035 protein disulfide oxidoreductase activity GSVIVG01010012001 13444644 13445959 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds. IEA GO:0015035 protein disulfide oxidoreductase activity GSVIVG01037222001 27764434 27771795 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01001369001 24053800 24059540 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01001369001 24053800 24059540 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01001369001 24053800 24059540 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01011081001 1748374 1750368 GSVIVG01020928001 16983726 16990038 GO:0005985 sucrose metabolic process The chemical reactions and pathways involving sucrose, the disaccharide fructofuranosyl-glucopyranoside. IEA Catalysis of the reaction: UDP-glucose + D-fructose 6-phosphate = UDP + sucrose 6-phosphate. IEA GO:0046524 sucrose-phosphate synthase activity GSVIVG01020928001 16983726 16990038 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: UDP-glucose + D-fructose 6-phosphate = UDP + sucrose 6-phosphate. IEA GO:0046524 sucrose-phosphate synthase activity GSVIVG01034131001 14959909 14971330 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01034131001 14959909 14971330 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01037982001 12006749 12023607 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01037982001 12006749 12023607 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01037982001 12006749 12023607 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01037982001 12006749 12023607 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01037982001 12006749 12023607 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007203001 30798488 30802480 GO:0042773 ATP synthesis coupled electron transport The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP. IEA Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. IEA GO:0008137 NADH dehydrogenase (ubiquinone) activity GSVIVG01007203001 30798488 30802480 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. IEA GO:0008137 NADH dehydrogenase (ubiquinone) activity GSVIVG01008166001 5160220 5164508 Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01026688001 4854198 4854667 GSVIVG01022642001 14011058 14014407 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01022642001 14011058 14014407 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032750001 1037781 1044951 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01032750001 1037781 1044951 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01032750001 1037781 1044951 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032750001 1037781 1044951 Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01025129001 4149680 4159575 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025129001 4149680 4159575 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01025129001 4149680 4159575 Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. IEA GO:0016881 acid-amino acid ligase activity GSVIVG01025129001 4149680 4159575 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01019851001 3833681 3835488 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01019851001 3833681 3835488 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01019851001 3833681 3835488 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01019851001 3833681 3835488 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01014587001 5398498 5399465 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GSVIVG01011716001 4832067 4841982 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GSVIVG01011716001 4832067 4841982 GO:0009607 response to biotic stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism. IEA GSVIVG01010300001 19206465 19214664 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01010300001 19206465 19214664 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01010300001 19206465 19214664 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01010300001 19206465 19214664 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01010300001 19206465 19214664 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01010300001 19206465 19214664 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01016045001 17812881 17813204 GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA GSVIVG01038097001 23476504 23482193 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GSVIVG01032947001 24525304 24525867 GSVIVG01037631001 6359412 6371752 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01037631001 6359412 6371752 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01037631001 6359412 6371752 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01037631001 6359412 6371752 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01037631001 6359412 6371752 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037631001 6359412 6371752 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037631001 6359412 6371752 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01037631001 6359412 6371752 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01001442001 21057073 21058799 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01001442001 21057073 21058799 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01001442001 21057073 21058799 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01001442001 21057073 21058799 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010197001 17179384 17239791 GSVIVG01024659001 7980159 7980302 GSVIVG01007636001 10982628 10987091 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01007636001 10982628 10987091 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01026635001 20870208 20881776 GO:0006298 mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026635001 20870208 20881776 GO:0006298 mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. IEA Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches. IEA GO:0030983 mismatched DNA binding GSVIVG01020229001 8824136 8826187 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01020229001 8824136 8826187 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01012285001 13051726 13053234 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01023161001 21785357 21791112 GSVIVG01000483001 14661830 14666329 GSVIVG01007074001 30060707 30061411 GSVIVG01000572001 6964073 6976804 GO:0016973 poly(A)+ mRNA export from nucleus The directed movement of poly(A)+ mRNA out of the nucleus into the cytoplasm. IEA GO:0005643 nuclear pore Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined. IEA GSVIVG01022954001 17584054 17584471 GSVIVG01020868001 775443 784939 GSVIVG01008653001 88282 90652 GSVIVG01029101001 19782559 19818479 GO:0006367 transcription initiation from RNA polymerase II promoter A transcription initiation process that results in RNA synthesis by RNA polymerase II. IEA Functions to initiate or regulate RNA polymerase II transcription. IEA GO:0003702 RNA polymerase II transcription factor activity GSVIVG01027613001 15054698 15058471 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0005839 proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. IEA GO:0004175 endopeptidase activity GSVIVG01027613001 15054698 15058471 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0005839 proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. IEA Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. IEA GO:0004298 threonine-type endopeptidase activity GSVIVG01031545001 17293458 17317439 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031545001 17293458 17317439 Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01026870001 19751112 19765965 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01026870001 19751112 19765965 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Catalysis of the reaction: adenosine + H2O = inosine + NH3. IEA GO:0004000 adenosine deaminase activity GSVIVG01036681001 23985952 23997831 GSVIVG01035898001 5460762 5461802 GSVIVG01026079001 24852933 24856629 GSVIVG01022311001 18407669 18411425 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01022311001 18407669 18411425 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01022311001 18407669 18411425 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01022311001 18407669 18411425 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01022311001 18407669 18411425 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01022311001 18407669 18411425 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01022311001 18407669 18411425 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01022311001 18407669 18411425 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016094001 18813812 18861073 GSVIVG01026362001 14992018 14993981 GSVIVG01008780001 1952680 1968096 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01008780001 1952680 1968096 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01008780001 1952680 1968096 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01008780001 1952680 1968096 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01008780001 1952680 1968096 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022785001 16565462 16578129 GSVIVG01014151001 865989 867580 GSVIVG01020986001 15891382 15916025 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01004782001 16091054 16091929 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01001259001 4843673 4844110 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01001259001 4843673 4844110 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01001259001 4843673 4844110 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01001259001 4843673 4844110 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01007617001 11181907 11182219 GSVIVG01019002001 17908890 17909153 GSVIVG01029509001 22125221 22149896 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029509001 22125221 22149896 Catalysis of the transfer of a functional group from one position to another within a single molecule. IEA GO:0016866 intramolecular transferase activity GSVIVG01021505001 6335026 6337103 GSVIVG01010450001 20708514 20711493 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01010450001 20708514 20711493 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01010450001 20708514 20711493 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015934 large ribosomal subunit The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01035370001 841053 846927 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01014316001 2589235 2590393 GSVIVG01010722001 12791679 12828448 GO:0016070 RNA metabolic process The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01010722001 12791679 12828448 GO:0016070 RNA metabolic process The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01010722001 12791679 12828448 GO:0016070 RNA metabolic process The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. IEA Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters. IEA GO:0004523 ribonuclease H activity GSVIVG01009926001 12457245 12463240 GSVIVG01023712001 9855633 9856433 GSVIVG01030873001 18161654 18163437 GSVIVG01008073001 6051778 6061880 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01025133001 4063960 4130994 GSVIVG01022164001 17158184 17159830 GSVIVG01036038001 7698369 7698578 GSVIVG01004400001 38382848 38383736 GSVIVG01005596001 40787808 40790591 GO:0006094 gluconeogenesis The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. IEA Catalysis of the reaction: source of phosphate + oxaloacetate = phosphoenolpyruvate + CO2. IEA GO:0004611 phosphoenolpyruvate carboxykinase activity GSVIVG01005596001 40787808 40790591 GO:0006094 gluconeogenesis The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. IEA Catalysis of the reaction: ATP + oxaloacetate = ADP + phosphoenolpyruvate + CO2. IEA GO:0004612 phosphoenolpyruvate carboxykinase (ATP) activity GSVIVG01005596001 40787808 40790591 GO:0006094 gluconeogenesis The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01005596001 40787808 40790591 GO:0006094 gluconeogenesis The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. IEA Interacting selectively and non-covalently with purine nucleotides, any compound consisting of a purine nucleoside esterified with (ortho)phosphate. IEA GO:0017076 purine nucleotide binding GSVIVG01037036001 8660792 8679474 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01037036001 8660792 8679474 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01037036001 8660792 8679474 GO:0006422 aspartyl-tRNA aminoacylation The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01037036001 8660792 8679474 GO:0006430 lysyl-tRNA aminoacylation The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01037036001 8660792 8679474 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01037036001 8660792 8679474 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01037036001 8660792 8679474 GO:0006422 aspartyl-tRNA aminoacylation The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01037036001 8660792 8679474 GO:0006430 lysyl-tRNA aminoacylation The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01037036001 8660792 8679474 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01037036001 8660792 8679474 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01037036001 8660792 8679474 GO:0006422 aspartyl-tRNA aminoacylation The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01037036001 8660792 8679474 GO:0006430 lysyl-tRNA aminoacylation The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01037036001 8660792 8679474 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp). IEA GO:0004815 aspartate-tRNA ligase activity GSVIVG01037036001 8660792 8679474 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp). IEA GO:0004815 aspartate-tRNA ligase activity GSVIVG01037036001 8660792 8679474 GO:0006422 aspartyl-tRNA aminoacylation The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp). IEA GO:0004815 aspartate-tRNA ligase activity GSVIVG01037036001 8660792 8679474 GO:0006430 lysyl-tRNA aminoacylation The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp). IEA GO:0004815 aspartate-tRNA ligase activity GSVIVG01037036001 8660792 8679474 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys). IEA GO:0004824 lysine-tRNA ligase activity GSVIVG01037036001 8660792 8679474 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys). IEA GO:0004824 lysine-tRNA ligase activity GSVIVG01037036001 8660792 8679474 GO:0006422 aspartyl-tRNA aminoacylation The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys). IEA GO:0004824 lysine-tRNA ligase activity GSVIVG01037036001 8660792 8679474 GO:0006430 lysyl-tRNA aminoacylation The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys). IEA GO:0004824 lysine-tRNA ligase activity GSVIVG01037036001 8660792 8679474 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037036001 8660792 8679474 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037036001 8660792 8679474 GO:0006422 aspartyl-tRNA aminoacylation The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037036001 8660792 8679474 GO:0006430 lysyl-tRNA aminoacylation The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037036001 8660792 8679474 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01037036001 8660792 8679474 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01037036001 8660792 8679474 GO:0006422 aspartyl-tRNA aminoacylation The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01037036001 8660792 8679474 GO:0006430 lysyl-tRNA aminoacylation The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01018284001 11889168 11951334 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018284001 11889168 11951334 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01012135001 1128473 1132261 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01012135001 1128473 1132261 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01016795001 1464066 1466320 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01016795001 1464066 1466320 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01016795001 1464066 1466320 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ribosomal RNA. IEA GO:0019843 rRNA binding GSVIVG01016795001 1464066 1466320 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with ribosomal RNA. IEA GO:0019843 rRNA binding GSVIVG01026677001 4640413 4642097 GSVIVG01015801001 17605998 17607175 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01015801001 17605998 17607175 Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01008767001 1806150 1811109 GSVIVG01028749001 19197891 19201020 GSVIVG01017122001 4394888 4395121 GSVIVG01012042001 1891402 1898953 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01012042001 1891402 1898953 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01002512001 35142457 35143983 GSVIVG01023767001 10804404 10806058 GSVIVG01001510001 5373991 5376501 GSVIVG01033619001 19234772 19236137 GSVIVG01025718001 12684287 12686486 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01021169001 2130094 2132217 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01021169001 2130094 2132217 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01035637001 2887667 2888436 GSVIVG01031190001 1330378 1336112 GO:0006725 cellular aromatic compound metabolic process The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031190001 1330378 1336112 GO:0006725 cellular aromatic compound metabolic process The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells. IEA Interacting selectively and non-covalently with ferrous iron, Fe(II). IEA GO:0008198 ferrous iron binding GSVIVG01031190001 1330378 1336112 GO:0006725 cellular aromatic compound metabolic process The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01018205001 13245041 13249262 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01037120001 28932158 28939425 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01037120001 28932158 28939425 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01035072001 1298335 1299312 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GSVIVG01035072001 1298335 1299312 GO:0009607 response to biotic stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism. IEA GSVIVG01033803001 17672307 17674459 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01031706001 3594091 3594261 GSVIVG01025526001 14306355 14324136 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025526001 14306355 14324136 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. IEA GO:0008080 N-acetyltransferase activity GSVIVG01025526001 14306355 14324136 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01038257001 24747037 24749868 GSVIVG01035870001 5078785 5087928 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01035870001 5078785 5087928 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01035870001 5078785 5087928 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01035870001 5078785 5087928 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030057001 9305299 9309335 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030057001 9305299 9309335 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01022114001 16701375 16704650 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01022114001 16701375 16704650 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01022114001 16701375 16704650 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01022114001 16701375 16704650 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024678001 7832730 7858088 GSVIVG01013072001 8757170 8762765 GSVIVG01017703001 2781822 2783804 GSVIVG01016089001 18707294 18716021 GO:0001510 RNA methylation Posttranscriptional addition of a methyl group to either a nucleotide or 2'-O ribose in a polyribonucleotide. Usually uses S-adenosylmethionine as a cofactor. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01016089001 18707294 18716021 GO:0009452 RNA capping The sequence of enzymatic reactions by which the 5' cap structure, an inverted 7-methylguanosine linked via a 5'-5' triphosphate bridge (m7G(5')ppp(5')X) to the first transcribed residue, is added to a nascent RNA polymerase II transcript. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01020409001 19907421 19915676 GSVIVG01022145001 16938037 16940516 GO:0007050 cell cycle arrest The process by which the cell cycle is halted during one of the normal phases (G1, S, G2, M). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Stops, prevents or reduces the activity of a cyclin-dependent protein kinase. IEA GO:0004861 cyclin-dependent protein kinase inhibitor activity GSVIVG01011693001 5080174 5087724 GSVIVG01009836001 11656850 11691536 GSVIVG01015095001 1000359 1001747 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015095001 1000359 1001747 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. IEA GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GSVIVG01001703001 12363481 12378235 GSVIVG01007720001 9936625 9941415 GO:0000162 tryptophan biosynthetic process The chemical reactions and pathways resulting in the formation of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; tryptophan is synthesized from chorismate via anthranilate. IEA Catalysis of the reaction: N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-a-D-ribose 1-diphosphate. IEA GO:0004048 anthranilate phosphoribosyltransferase activity GSVIVG01007720001 9936625 9941415 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-a-D-ribose 1-diphosphate. IEA GO:0004048 anthranilate phosphoribosyltransferase activity GSVIVG01007720001 9936625 9941415 GO:0000162 tryptophan biosynthetic process The chemical reactions and pathways resulting in the formation of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; tryptophan is synthesized from chorismate via anthranilate. IEA Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01007720001 9936625 9941415 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01005083001 14365747 14369668 GSVIVG01034358001 17517508 17559361 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01011739001 4673767 4683777 GSVIVG01020701001 3005962 3011245 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01020701001 3005962 3011245 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01000391001 616229 620775 GO:0006536 glutamate metabolic process The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000391001 616229 620775 GO:0019752 carboxylic acid metabolic process The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000391001 616229 620775 GO:0006536 glutamate metabolic process The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid. IEA Catalysis of the reaction: L-glutamate = 4-aminobutanoate + CO2. IEA GO:0004351 glutamate decarboxylase activity GSVIVG01000391001 616229 620775 GO:0019752 carboxylic acid metabolic process The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). IEA Catalysis of the reaction: L-glutamate = 4-aminobutanoate + CO2. IEA GO:0004351 glutamate decarboxylase activity GSVIVG01000391001 616229 620775 GO:0006536 glutamate metabolic process The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid. IEA Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. IEA GO:0016831 carboxy-lyase activity GSVIVG01000391001 616229 620775 GO:0019752 carboxylic acid metabolic process The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). IEA Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. IEA GO:0016831 carboxy-lyase activity GSVIVG01000391001 616229 620775 GO:0006536 glutamate metabolic process The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01000391001 616229 620775 GO:0019752 carboxylic acid metabolic process The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01000944001 22122605 22131879 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010508001 21186172 21192801 GSVIVG01013822001 4867987 4869909 GO:0006566 threonine metabolic process The chemical reactions and pathways involving threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: ATP + L-homoserine = ADP + O-phospho-L-homoserine. IEA GO:0004413 homoserine kinase activity GSVIVG01013822001 4867987 4869909 GO:0006566 threonine metabolic process The chemical reactions and pathways involving threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013822001 4867987 4869909 GO:0006566 threonine metabolic process The chemical reactions and pathways involving threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with manganese (Mn) ions. IEA GO:0030145 manganese ion binding GSVIVG01013822001 4867987 4869909 GO:0006566 threonine metabolic process The chemical reactions and pathways involving threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Functions in the storage of nutritious substrates. IEA GO:0045735 nutrient reservoir activity GSVIVG01013822001 4867987 4869909 GO:0006566 threonine metabolic process The chemical reactions and pathways involving threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01013346001 12490740 12491937 GSVIVG01012168001 850561 867482 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01012168001 850561 867482 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01012168001 850561 867482 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012168001 850561 867482 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012168001 850561 867482 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012168001 850561 867482 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012168001 850561 867482 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01012168001 850561 867482 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01013143001 7643964 7709371 GO:0006506 GPI anchor biosynthetic process The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol moiety is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate moiety, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage. IEA GO:0005789 endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum. IEA Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). IEA GO:0016746 transferase activity, transferring acyl groups GSVIVG01013143001 7643964 7709371 GO:0006506 GPI anchor biosynthetic process The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol moiety is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate moiety, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). IEA GO:0016746 transferase activity, transferring acyl groups GSVIVG01000410001 7625592 7626926 Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01000410001 7625592 7626926 Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01020076001 10638811 10654242 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01016327001 5028969 5045341 GSVIVG01035158001 12418781 12418915 GSVIVG01008172001 5107491 5115700 GSVIVG01018215001 13153421 13155862 GSVIVG01001512001 5386762 5425428 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01028992001 10300036 10315809 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024587001 8605255 8607990 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01024587001 8605255 8607990 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01024587001 8605255 8607990 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01024587001 8605255 8607990 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01024587001 8605255 8607990 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01024587001 8605255 8607990 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01024587001 8605255 8607990 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024587001 8605255 8607990 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016395001 4236697 4239064 GSVIVG01031083001 2506767 2507183 GSVIVG01026627001 20906156 20908236 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01026627001 20906156 20908236 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01026627001 20906156 20908236 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01026627001 20906156 20908236 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01026627001 20906156 20908236 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01026627001 20906156 20908236 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01026627001 20906156 20908236 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01026627001 20906156 20908236 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01026627001 20906156 20908236 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01026627001 20906156 20908236 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01026627001 20906156 20908236 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01026627001 20906156 20908236 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01026627001 20906156 20908236 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01026627001 20906156 20908236 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01026627001 20906156 20908236 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01026627001 20906156 20908236 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01026627001 20906156 20908236 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01026627001 20906156 20908236 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01014449001 3863616 3864196 GSVIVG01001118001 22748079 22755774 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01001118001 22748079 22755774 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01001118001 22748079 22755774 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01037102001 29115652 29117874 GO:0006014 D-ribose metabolic process The chemical reactions and pathways involving D-ribose (ribo-pentose). As beta-D-ribofuranose, D-ribose forms the glycose moiety of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12. IEA Catalysis of the reaction: ATP + adenosine = ADP + AMP. IEA GO:0004001 adenosine kinase activity GSVIVG01037102001 29115652 29117874 GO:0006166 purine ribonucleoside salvage Any process which produces a purine nucleoside from derivatives of it, without de novo synthesis. IEA Catalysis of the reaction: ATP + adenosine = ADP + AMP. IEA GO:0004001 adenosine kinase activity GSVIVG01037102001 29115652 29117874 GO:0006014 D-ribose metabolic process The chemical reactions and pathways involving D-ribose (ribo-pentose). As beta-D-ribofuranose, D-ribose forms the glycose moiety of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12. IEA Catalysis of the reaction: ATP + D-ribose = ADP + D-ribose 5-phosphate. IEA GO:0004747 ribokinase activity GSVIVG01037102001 29115652 29117874 GO:0006166 purine ribonucleoside salvage Any process which produces a purine nucleoside from derivatives of it, without de novo synthesis. IEA Catalysis of the reaction: ATP + D-ribose = ADP + D-ribose 5-phosphate. IEA GO:0004747 ribokinase activity GSVIVG01000214001 16138913 16139197 GSVIVG01038410001 11932557 11941812 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01010696001 11934886 11938437 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010696001 11934886 11938437 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010696001 11934886 11938437 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01010696001 11934886 11938437 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01010696001 11934886 11938437 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01010696001 11934886 11938437 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01002092001 32800498 32801958 GSVIVG01014487001 4363234 4364077 GSVIVG01000091001 3423978 3440699 GSVIVG01010274001 18696201 18697377 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GSVIVG01038038001 16609679 16610200 GSVIVG01021228001 2776013 2782944 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01021228001 2776013 2782944 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01021228001 2776013 2782944 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01021228001 2776013 2782944 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01021228001 2776013 2782944 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037771001 7719373 7721709 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01037771001 7719373 7721709 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01020755001 2323491 2329057 GSVIVG01025173001 3720048 3729391 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025173001 3720048 3729391 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01025173001 3720048 3729391 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01025173001 3720048 3729391 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01025173001 3720048 3729391 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024411001 2200094 2213110 GSVIVG01015623001 14222858 14227556 GSVIVG01009079001 4765816 4772366 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01009079001 4765816 4772366 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01009079001 4765816 4772366 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01009079001 4765816 4772366 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01008549001 943892 946048 GSVIVG01034261001 13655796 13656815 GSVIVG01027850001 8611049 8614480 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01027850001 8611049 8614480 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018123001 6754914 6756137 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01032650001 1813649 1814533 GO:0042254 ribosome biogenesis The process of the formation of the constituents of the ribosome subunits, their assembly, and their transport to the sites of protein synthesis. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA GSVIVG01001906001 7076749 7078862 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01001906001 7076749 7078862 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01001906001 7076749 7078862 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with 5S ribosomal RNA, the smallest RNA constituent of a ribosome. IEA GO:0008097 5S rRNA binding GSVIVG01001906001 7076749 7078862 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with 5S ribosomal RNA, the smallest RNA constituent of a ribosome. IEA GO:0008097 5S rRNA binding GSVIVG01022125001 16775470 16777793 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion. IEA GO:0004806 triglyceride lipase activity GSVIVG01014303001 2494739 2499659 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014303001 2494739 2499659 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014303001 2494739 2499659 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014303001 2494739 2499659 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014303001 2494739 2499659 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027825001 8218852 8229689 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01027825001 8218852 8229689 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01027825001 8218852 8229689 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01000305001 2756417 2756728 GSVIVG01002796001 36480981 36481313 GO:0007205 activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway The initiation of the activity of the inactive enzyme protein kinase C as the result of a series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol 3-phosphate. IEA GO:0004143 diacylglycerol kinase activity GSVIVG01019358001 523519 524539 GSVIVG01019282001 2073883 2077316 Catalysis of the transfer of the amide nitrogen of glutamine to a variety of substrates. GATases catalyze two separate reactions at two active sites, which are located either on a single polypeptide chain or on different subunits. In the glutaminase reaction, glutamine is hydrolyzed to glutamate and ammonia, which is added to an acceptor substrate in the synthase reaction. IEA GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor GSVIVG01019058001 17261346 17265845 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01019058001 17261346 17265845 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01019058001 17261346 17265845 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with 5S ribosomal RNA, the smallest RNA constituent of a ribosome. IEA GO:0008097 5S rRNA binding GSVIVG01019058001 17261346 17265845 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with 5S ribosomal RNA, the smallest RNA constituent of a ribosome. IEA GO:0008097 5S rRNA binding GSVIVG01008727001 1474564 1474728 GSVIVG01032069001 23034188 23056269 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01028401001 7165352 7202910 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01028401001 7165352 7202910 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01028401001 7165352 7202910 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01028401001 7165352 7202910 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01028401001 7165352 7202910 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003348001 9238224 9241249 GO:0015991 ATP hydrolysis coupled proton transport The transport of protons against an electrochemical gradient, using energy from ATP hydrolysis. IEA GO:0033179 proton-transporting V-type ATPase, V0 domain A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01019540001 1459283 1461484 GSVIVG01000713001 89628 110743 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. IEA GO:0008080 N-acetyltransferase activity GSVIVG01028095001 3757602 3760767 GO:0006366 transcription from RNA polymerase II promoter The synthesis of RNA from a DNA template by RNA polymerase II (Pol II), originating at a Pol II-specific promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs). IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01028095001 3757602 3760767 GO:0006366 transcription from RNA polymerase II promoter The synthesis of RNA from a DNA template by RNA polymerase II (Pol II), originating at a Pol II-specific promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs). IEA Functions to initiate or regulate RNA polymerase II transcription. IEA GO:0003702 RNA polymerase II transcription factor activity GSVIVG01009469001 8624953 8627945 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01036344001 3982770 3988761 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01036344001 3982770 3988761 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01031815001 4651538 4653024 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01031815001 4651538 4653024 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01034614001 14355531 14357004 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01034614001 14355531 14357004 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds. IEA GO:0015035 protein disulfide oxidoreductase activity GSVIVG01026504001 22479191 22485297 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01026504001 22479191 22485297 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01026504001 22479191 22485297 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01026504001 22479191 22485297 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01026504001 22479191 22485297 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01026504001 22479191 22485297 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01026493001 22732854 22740064 GSVIVG01014872001 10992613 10993131 GSVIVG01010596001 16185826 16189731 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01010596001 16185826 16189731 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01010596001 16185826 16189731 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01010596001 16185826 16189731 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01010596001 16185826 16189731 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031557001 17963634 17985356 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01031557001 17963634 17985356 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026287001 12716999 12717535 GSVIVG01025203001 3347941 3354859 GSVIVG01029829001 221735 227238 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01029829001 221735 227238 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01029829001 221735 227238 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01029829001 221735 227238 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01029829001 221735 227238 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029829001 221735 227238 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029829001 221735 227238 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01035762001 4078393 4085329 GSVIVG01007891001 7897104 7901315 GSVIVG01023212001 21030034 21033728 GSVIVG01012043001 1887739 1890871 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012043001 1887739 1890871 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01012043001 1887739 1890871 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01031742001 3989798 3991292 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031742001 3989798 3991292 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the endohydrolysis of 1,4-alpha-D-glucosidic linkages in polysaccharides containing three or more 1,4-alpha-linked D-glucose units. IEA GO:0004556 alpha-amylase activity GSVIVG01031742001 3989798 3991292 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01031742001 3989798 3991292 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01033786001 17833920 17835377 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01012417001 604923 605562 GSVIVG01018801001 19742618 19746072 Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. IEA GO:0016853 isomerase activity GSVIVG01008354001 2947348 3002451 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01008354001 2947348 3002451 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008354001 2947348 3002451 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. IEA GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GSVIVG01008354001 2947348 3002451 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species. IEA GO:0031418 L-ascorbic acid binding GSVIVG01001498001 5166167 5172182 GSVIVG01003127001 7505959 7507546 GSVIVG01007212001 30898565 30900160 GSVIVG01008379001 2684891 2685735 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01016580001 2645375 2649870 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. IEA GO:0016597 amino acid binding GSVIVG01000733001 284900 285714 GSVIVG01010294001 19156179 19163419 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01031184001 1418757 1421326 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01031184001 1418757 1421326 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01020620001 3691227 3697513 GSVIVG01023191001 21327919 21331800 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023191001 21327919 21331800 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022768001 16300907 16318428 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0005839 proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. IEA Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. IEA GO:0004298 threonine-type endopeptidase activity GSVIVG01001402001 24291613 24294743 GSVIVG01026270001 15223735 15225081 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026270001 15223735 15225081 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026270001 15223735 15225081 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026270001 15223735 15225081 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01026270001 15223735 15225081 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01026270001 15223735 15225081 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01026270001 15223735 15225081 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01026270001 15223735 15225081 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01026270001 15223735 15225081 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01017953001 5047104 5051884 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01017953001 5047104 5051884 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01017953001 5047104 5051884 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01017953001 5047104 5051884 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017953001 5047104 5051884 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01009558001 9400859 9407321 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01009558001 9400859 9407321 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01022422001 19975031 19986840 GSVIVG01013508001 1999267 2009924 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01013508001 1999267 2009924 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01013508001 1999267 2009924 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013508001 1999267 2009924 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013508001 1999267 2009924 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01013508001 1999267 2009924 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01000597001 6670789 6674449 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000597001 6670789 6674449 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000597001 6670789 6674449 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01000597001 6670789 6674449 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01000597001 6670789 6674449 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01000597001 6670789 6674449 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01000597001 6670789 6674449 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01000597001 6670789 6674449 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01032517001 28025514 28028348 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01032517001 28025514 28028348 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01032517001 28025514 28028348 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01032517001 28025514 28028348 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01029151001 19050674 19095228 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029151001 19050674 19095228 Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. IEA GO:0008483 transaminase activity GSVIVG01029151001 19050674 19095228 Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01025518001 7306 8123 GSVIVG01013161001 7370114 7372531 GSVIVG01034169001 14674591 14690865 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01034169001 14674591 14690865 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01036586001 18659449 18661717 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01022651001 14137361 14137814 GSVIVG01031301001 532518 537488 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01031301001 532518 537488 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01031301001 532518 537488 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01031301001 532518 537488 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003872001 73212 75116 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0008076 voltage-gated potassium channel complex A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01003872001 73212 75116 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01003872001 73212 75116 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0008076 voltage-gated potassium channel complex A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01003872001 73212 75116 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01011665001 5403228 5412360 GSVIVG01013661001 2096734 2101220 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01013661001 2096734 2101220 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01013661001 2096734 2101220 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01013661001 2096734 2101220 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01013661001 2096734 2101220 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01013661001 2096734 2101220 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033207001 9766798 9768784 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01038367001 13845301 13845737 GSVIVG01000361001 12184512 12184804 GSVIVG01023225001 20949135 20952548 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01023225001 20949135 20952548 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01023225001 20949135 20952548 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01023225001 20949135 20952548 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01023225001 20949135 20952548 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01023225001 20949135 20952548 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023225001 20949135 20952548 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023225001 20949135 20952548 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023225001 20949135 20952548 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023225001 20949135 20952548 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023225001 20949135 20952548 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01023225001 20949135 20952548 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01023225001 20949135 20952548 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01023225001 20949135 20952548 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01023225001 20949135 20952548 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01017054001 3817312 3820469 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033375001 21117825 21120262 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01028809001 18530210 18534998 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01028809001 18530210 18534998 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01028809001 18530210 18534998 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01028809001 18530210 18534998 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028809001 18530210 18534998 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01028809001 18530210 18534998 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01019403001 360000 362037 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01019403001 360000 362037 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01019403001 360000 362037 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01019403001 360000 362037 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031179001 1449753 1450640 GSVIVG01012249001 194107 206538 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012249001 194107 206538 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012249001 194107 206538 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012249001 194107 206538 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01012249001 194107 206538 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01012249001 194107 206538 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01012249001 194107 206538 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01012249001 194107 206538 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01012249001 194107 206538 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01017868001 4134799 4139324 GO:0006542 glutamine biosynthetic process The chemical reactions and pathways resulting in the formation of glutamine, 2-amino-4-carbamoylbutanoic acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01017868001 4134799 4139324 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01017868001 4134799 4139324 GO:0006542 glutamine biosynthetic process The chemical reactions and pathways resulting in the formation of glutamine, 2-amino-4-carbamoylbutanoic acid. IEA Catalysis of the reaction: ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine. IEA GO:0004356 glutamate-ammonia ligase activity GSVIVG01017868001 4134799 4139324 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA Catalysis of the reaction: ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine. IEA GO:0004356 glutamate-ammonia ligase activity GSVIVG01010000001 13311780 13316460 GSVIVG01036904001 17912098 17913546 GSVIVG01027584001 15327284 15340495 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01027584001 15327284 15340495 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01027584001 15327284 15340495 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01027584001 15327284 15340495 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01001656001 13974454 14000593 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01001656001 13974454 14000593 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01001656001 13974454 14000593 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01001656001 13974454 14000593 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01001656001 13974454 14000593 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01005849001 22235399 22237225 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01005849001 22235399 22237225 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01004085001 14688390 14693664 GO:0009116 nucleoside metabolic process The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine). IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01004085001 14688390 14693664 GO:0009165 nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates). IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01004085001 14688390 14693664 GO:0009116 nucleoside metabolic process The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine). IEA Catalysis of the reaction: ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate. IEA GO:0004749 ribose phosphate diphosphokinase activity GSVIVG01004085001 14688390 14693664 GO:0009165 nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates). IEA Catalysis of the reaction: ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate. IEA GO:0004749 ribose phosphate diphosphokinase activity GSVIVG01009014001 4283723 4287720 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01022715001 15494255 15496761 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. IEA GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GSVIVG01038278001 24919816 24925033 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01032082001 22907329 22911879 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032082001 22907329 22911879 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01023217001 21001414 21018344 GO:0006680 glucosylceramide catabolic process The chemical reactions and pathways resulting in the breakdown of glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01023217001 21001414 21018344 GO:0006680 glucosylceramide catabolic process The chemical reactions and pathways resulting in the breakdown of glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine. IEA GO:0004348 glucosylceramidase activity GSVIVG01000763001 506083 508699 GSVIVG01038419001 12008664 12012720 GO:0016568 chromatin modification The alteration of DNA or protein in chromatin, which may result in changing the chromatin structure. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01038419001 12008664 12012720 GO:0016568 chromatin modification The alteration of DNA or protein in chromatin, which may result in changing the chromatin structure. IEA Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone. IEA GO:0004402 histone acetyltransferase activity GSVIVG01038419001 12008664 12012720 GO:0016568 chromatin modification The alteration of DNA or protein in chromatin, which may result in changing the chromatin structure. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01023817001 3227134 3234563 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01023817001 3227134 3234563 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01023817001 3227134 3234563 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01000548001 7230367 7232678 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01001909001 7091880 7101101 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001909001 7091880 7101101 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001909001 7091880 7101101 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01001909001 7091880 7101101 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01001909001 7091880 7101101 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01001909001 7091880 7101101 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01001909001 7091880 7101101 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001909001 7091880 7101101 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01011156001 7411683 7412545 GSVIVG01026840001 20058201 20059260 GSVIVG01007281001 31241829 31245259 GSVIVG01030652001 7508222 7511208 GSVIVG01015244001 2076570 2077463 Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. IEA GO:0008171 O-methyltransferase activity GSVIVG01034054001 15524220 15526948 GSVIVG01033380001 21080292 21085479 GSVIVG01035023001 980130 980766 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01035023001 980130 980766 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01036533001 23125718 23136209 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01034452001 21103612 21103912 GSVIVG01016190001 6881405 6883227 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004197 cysteine-type endopeptidase activity GSVIVG01016190001 6881405 6883227 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01016190001 6881405 6883227 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01016190001 6881405 6883227 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01018577001 13107270 13109122 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01015924001 15210997 15212176 GSVIVG01004020001 1385233 1395223 GSVIVG01009563001 9442834 9444226 GSVIVG01026110001 24488731 24491585 GSVIVG01026074001 24927149 24930210 GSVIVG01015863001 18574618 18584369 GSVIVG01028410001 7295389 7297933 GSVIVG01029053001 11492334 11500753 Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum. IEA GO:0003993 acid phosphatase activity GSVIVG01029053001 11492334 11500753 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01029053001 11492334 11500753 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01004882001 16372764 16373024 GSVIVG01008474001 1571626 1575393 GSVIVG01008752001 1712533 1714096 Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage. IEA GO:0016209 antioxidant activity GSVIVG01008752001 1712533 1714096 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01017356001 7186659 7187417 GSVIVG01006448001 26060601 26066088 GSVIVG01024705001 7606443 7612267 GO:0046907 intracellular transport The directed movement of substances within a cell. IEA GSVIVG01028485001 8233948 8237014 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01028485001 8233948 8237014 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01000045001 3054222 3057210 GSVIVG01016214001 6527319 6528128 GSVIVG01012213001 515730 520849 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016599001 2508143 2518578 GSVIVG01001700001 12215289 12216459 GSVIVG01005136001 18484866 18493853 GSVIVG01026520001 22297590 22298477 GSVIVG01000978001 11046031 11046377 GSVIVG01001725001 529536 531330 GSVIVG01037421001 14039246 14083826 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01037421001 14039246 14083826 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end. IEA GO:0004527 exonuclease activity GSVIVG01032592001 28646091 28646822 GSVIVG01027057001 18284926 18290584 GSVIVG01014244001 1908116 1925741 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01014244001 1908116 1925741 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01014244001 1908116 1925741 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01014244001 1908116 1925741 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01014244001 1908116 1925741 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01014244001 1908116 1925741 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01019649001 2200731 2201170 GSVIVG01020024001 11448690 11455844 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). IEA GO:0003755 peptidyl-prolyl cis-trans isomerase activity GSVIVG01012237001 305943 311685 GO:0006014 D-ribose metabolic process The chemical reactions and pathways involving D-ribose (ribo-pentose). As beta-D-ribofuranose, D-ribose forms the glycose moiety of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12. IEA Catalysis of the reaction: ATP + D-ribose = ADP + D-ribose 5-phosphate. IEA GO:0004747 ribokinase activity GSVIVG01037047001 8403058 8408354 GSVIVG01030007001 8892148 8897392 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01030007001 8892148 8897392 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01030007001 8892148 8897392 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01030007001 8892148 8897392 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01030007001 8892148 8897392 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01030007001 8892148 8897392 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01018319001 11160345 11164486 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01018319001 11160345 11164486 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01018319001 11160345 11164486 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01018319001 11160345 11164486 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01018319001 11160345 11164486 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01018319001 11160345 11164486 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018319001 11160345 11164486 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018319001 11160345 11164486 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018319001 11160345 11164486 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018319001 11160345 11164486 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018319001 11160345 11164486 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01018319001 11160345 11164486 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01018319001 11160345 11164486 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01018319001 11160345 11164486 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01018319001 11160345 11164486 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01014791001 9762238 9764332 GSVIVG01018905001 18748769 18770419 GSVIVG01011857001 3522820 3525603 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01011857001 3522820 3525603 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01011857001 3522820 3525603 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01011857001 3522820 3525603 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01011857001 3522820 3525603 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021041001 14827685 14829753 GO:0006730 one-carbon metabolic process The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021041001 14827685 14829753 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021041001 14827685 14829753 GO:0006730 one-carbon metabolic process The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. IEA Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine. IEA GO:0004013 adenosylhomocysteinase activity GSVIVG01021041001 14827685 14829753 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine. IEA GO:0004013 adenosylhomocysteinase activity GSVIVG01021041001 14827685 14829753 GO:0006730 one-carbon metabolic process The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01021041001 14827685 14829753 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01036747001 23045181 23055363 GSVIVG01018401001 9713821 9742517 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01018401001 9713821 9742517 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01008570001 802904 807282 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01015235001 2013249 2016589 GSVIVG01031270001 671204 676334 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031270001 671204 676334 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031270001 671204 676334 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01034912001 65307 83720 GSVIVG01019059001 17250291 17259108 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Enables the directed movement of acyl groups into, out of, within or between cells. IEA GO:0000036 acyl carrier activity GSVIVG01019059001 17250291 17259108 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Interacting selectizely with phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate). IEA GO:0031177 phosphopantetheine binding GSVIVG01019059001 17250291 17259108 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. IEA GO:0048037 cofactor binding GSVIVG01014551001 5056097 5064335 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01014551001 5056097 5064335 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01014551001 5056097 5064335 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01011373001 29072385 29101553 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01011373001 29072385 29101553 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01011373001 29072385 29101553 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01011373001 29072385 29101553 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01011373001 29072385 29101553 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031878001 5052865 5063441 GSVIVG01030075001 9617262 9622015 GO:0019028 viral capsid The protein coat that surrounds the infective nucleic acid in some virus particles. It comprises numerous regularly arranged subunits, or capsomeres. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01031496001 17935141 17936851 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01003562001 14663873 14668801 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01003562001 14663873 14668801 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01003562001 14663873 14668801 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003562001 14663873 14668801 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003562001 14663873 14668801 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01003562001 14663873 14668801 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01035975001 6678208 6682125 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01003759001 12436825 12442146 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01027901001 9189123 9191139 GSVIVG01028680001 12032065 12032977 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018187001 13421491 13431292 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01014895001 11363218 11363439 GSVIVG01032259001 14168858 14173530 GSVIVG01030721001 14545145 14545405 GSVIVG01007437001 31874337 31893351 GO:0006397 mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01007437001 31874337 31893351 GO:0006397 mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01007437001 31874337 31893351 GO:0006397 mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01037160001 28439007 28443747 GSVIVG01031720001 3794273 3796050 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01031720001 3794273 3796050 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01038535001 11194241 11238920 GSVIVG01035667001 3157830 3165913 GSVIVG01015661001 15175241 15184285 GSVIVG01010233001 18021456 18021599 GSVIVG01014430001 3658552 3664452 GO:0017004 cytochrome complex assembly The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01014430001 3658552 3664452 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01007877001 8035243 8037678 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01007877001 8035243 8037678 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01007877001 8035243 8037678 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01007877001 8035243 8037678 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01011785001 4154897 4163111 GSVIVG01037004001 9050245 9061593 GSVIVG01017365001 7403775 7405949 GSVIVG01030519001 6426333 6429501 GSVIVG01035855001 4902231 4906088 GSVIVG01014811001 10049239 10052163 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with transfer RNA. IEA GO:0000049 tRNA binding GSVIVG01014811001 10049239 10052163 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe). IEA GO:0004826 phenylalanine-tRNA ligase activity GSVIVG01014811001 10049239 10052163 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010535001 21560278 21561387 GSVIVG01008915001 3359361 3369305 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01025623001 13519554 13523591 GSVIVG01037543001 11726875 11729630 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01001070001 7256605 7262019 GSVIVG01036921001 17582981 17584459 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GSVIVG01013533001 2450247 2465001 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013533001 2450247 2465001 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013533001 2450247 2465001 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013533001 2450247 2465001 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025221001 3088556 3092392 GSVIVG01017193001 5188899 5189932 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01005239001 19752619 19752702 GSVIVG01015483001 4093242 4093418 GSVIVG01001275001 4898034 4901145 GO:0005992 trehalose biosynthetic process The chemical reactions and pathways resulting in the formation of trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001275001 4898034 4901145 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001275001 4898034 4901145 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001275001 4898034 4901145 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001275001 4898034 4901145 GO:0005992 trehalose biosynthetic process The chemical reactions and pathways resulting in the formation of trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01001275001 4898034 4901145 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01001275001 4898034 4901145 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01001275001 4898034 4901145 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01001275001 4898034 4901145 GO:0005992 trehalose biosynthetic process The chemical reactions and pathways resulting in the formation of trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01001275001 4898034 4901145 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01001275001 4898034 4901145 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01001275001 4898034 4901145 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01013382001 817583 819451 GSVIVG01024069001 1372252 1381336 Catalysis of the transfer of the amide nitrogen of glutamine to a variety of substrates. GATases catalyze two separate reactions at two active sites, which are located either on a single polypeptide chain or on different subunits. In the glutaminase reaction, glutamine is hydrolyzed to glutamate and ammonia, which is added to an acceptor substrate in the synthase reaction. IEA GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor GSVIVG01017647001 2350353 2356081 GO:0006820 anion transport The directed movement of anions, atoms or small molecules with a net negative charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA IEA GO:0005452 inorganic anion exchanger activity GSVIVG01017647001 2350353 2356081 GO:0006820 anion transport The directed movement of anions, atoms or small molecules with a net negative charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA IEA GO:0005452 inorganic anion exchanger activity GSVIVG01017647001 2350353 2356081 GO:0006820 anion transport The directed movement of anions, atoms or small molecules with a net negative charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA IEA GO:0015380 anion exchanger activity GSVIVG01017647001 2350353 2356081 GO:0006820 anion transport The directed movement of anions, atoms or small molecules with a net negative charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA IEA GO:0015380 anion exchanger activity GSVIVG01003871001 50174 63305 GSVIVG01017852001 4032054 4034145 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin and L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. IEA GO:0008113 peptide-methionine-(S)-S-oxide reductase activity GSVIVG01034139001 14886865 14891657 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01034139001 14886865 14891657 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01034139001 14886865 14891657 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01034139001 14886865 14891657 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01034139001 14886865 14891657 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01034139001 14886865 14891657 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01023231001 20901209 20910194 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01016929001 2663930 2667215 GO:0019310 inositol catabolic process The chemical reactions and pathways resulting in the breakdown of inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01016929001 2663930 2667215 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01016929001 2663930 2667215 GO:0019310 inositol catabolic process The chemical reactions and pathways resulting in the breakdown of inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016929001 2663930 2667215 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016929001 2663930 2667215 GO:0019310 inositol catabolic process The chemical reactions and pathways resulting in the breakdown of inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: myo-inositol + O2 = D-glucuronate + H2O. IEA GO:0050113 inositol oxygenase activity GSVIVG01016929001 2663930 2667215 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: myo-inositol + O2 = D-glucuronate + H2O. IEA GO:0050113 inositol oxygenase activity GSVIVG01027750001 7384132 7393730 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01029175001 18940464 18942560 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01029175001 18940464 18942560 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01029175001 18940464 18942560 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01029175001 18940464 18942560 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01029175001 18940464 18942560 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01029175001 18940464 18942560 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01029175001 18940464 18942560 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01029175001 18940464 18942560 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01023844001 3032234 3033376 GSVIVG01013593001 21261670 21280197 GSVIVG01010058001 14302829 14303488 GSVIVG01022653001 14152897 14154916 GSVIVG01024871001 6337033 6342377 GSVIVG01016031001 17630406 17630754 GSVIVG01023930001 2413497 2420431 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01023930001 2413497 2420431 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01023930001 2413497 2420431 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01023930001 2413497 2420431 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01023930001 2413497 2420431 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025593001 13772721 13779581 GSVIVG01023673001 8926353 8936907 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01023673001 8926353 8936907 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01023673001 8926353 8936907 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01023673001 8926353 8936907 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018805001 19714347 19719359 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01018805001 19714347 19719359 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01016550001 2880916 2883022 GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016550001 2880916 2883022 GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016550001 2880916 2883022 GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016550001 2880916 2883022 GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016550001 2880916 2883022 GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016550001 2880916 2883022 GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012221001 459188 463238 GSVIVG01035306001 240307 241284 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01035306001 240307 241284 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006681001 27452158 27456606 GSVIVG01033866001 17160925 17161240 GSVIVG01017355001 7150350 7184496 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017355001 7150350 7184496 GO:0009408 response to heat A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017355001 7150350 7184496 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01017355001 7150350 7184496 GO:0009408 response to heat A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01017355001 7150350 7184496 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01017355001 7150350 7184496 GO:0009408 response to heat A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01036562001 23478598 23480350 GSVIVG01008205001 4702498 4708871 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01008205001 4702498 4708871 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01008205001 4702498 4708871 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01008205001 4702498 4708871 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01008205001 4702498 4708871 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01008205001 4702498 4708871 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01008205001 4702498 4708871 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008205001 4702498 4708871 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008205001 4702498 4708871 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008205001 4702498 4708871 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008205001 4702498 4708871 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008205001 4702498 4708871 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008205001 4702498 4708871 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the movement of phospholipids from one membrane face to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP. IEA GO:0004012 phospholipid-translocating ATPase activity GSVIVG01008205001 4702498 4708871 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the movement of phospholipids from one membrane face to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP. IEA GO:0004012 phospholipid-translocating ATPase activity GSVIVG01008205001 4702498 4708871 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the movement of phospholipids from one membrane face to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP. IEA GO:0004012 phospholipid-translocating ATPase activity GSVIVG01008205001 4702498 4708871 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the movement of phospholipids from one membrane face to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP. IEA GO:0004012 phospholipid-translocating ATPase activity GSVIVG01008205001 4702498 4708871 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the movement of phospholipids from one membrane face to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP. IEA GO:0004012 phospholipid-translocating ATPase activity GSVIVG01008205001 4702498 4708871 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the movement of phospholipids from one membrane face to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP. IEA GO:0004012 phospholipid-translocating ATPase activity GSVIVG01008205001 4702498 4708871 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008205001 4702498 4708871 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008205001 4702498 4708871 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008205001 4702498 4708871 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008205001 4702498 4708871 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008205001 4702498 4708871 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008205001 4702498 4708871 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01008205001 4702498 4708871 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01008205001 4702498 4708871 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01008205001 4702498 4708871 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01008205001 4702498 4708871 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01008205001 4702498 4708871 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01008205001 4702498 4708871 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01008205001 4702498 4708871 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01008205001 4702498 4708871 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01008205001 4702498 4708871 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01008205001 4702498 4708871 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01008205001 4702498 4708871 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01011396001 29315042 29331105 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01011396001 29315042 29331105 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01011396001 29315042 29331105 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033615001 19247036 19269425 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01027739001 7341804 7344678 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025406001 1024291 1031446 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025406001 1024291 1031446 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01025406001 1024291 1031446 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA A ligand-dependent receptor found in the nucleus of the cell. IEA GO:0004879 ligand-dependent nuclear receptor activity GSVIVG01021479001 5981689 5981924 GSVIVG01017866001 4127406 4132500 GO:0006824 cobalt ion transport The directed movement of cobalt (Co) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. IEA GO:0008137 NADH dehydrogenase (ubiquinone) activity GSVIVG01017866001 4127406 4132500 GO:0009236 cobalamin biosynthetic process The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. IEA Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. IEA GO:0008137 NADH dehydrogenase (ubiquinone) activity GSVIVG01017866001 4127406 4132500 GO:0042773 ATP synthesis coupled electron transport The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP. IEA Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. IEA GO:0008137 NADH dehydrogenase (ubiquinone) activity GSVIVG01017866001 4127406 4132500 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. IEA GO:0008137 NADH dehydrogenase (ubiquinone) activity GSVIVG01017866001 4127406 4132500 GO:0006824 cobalt ion transport The directed movement of cobalt (Co) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the transfer of cobalt (Co) ions from one side of a membrane to the other. IEA GO:0015087 cobalt ion transmembrane transporter activity GSVIVG01017866001 4127406 4132500 GO:0009236 cobalamin biosynthetic process The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. IEA Catalysis of the transfer of cobalt (Co) ions from one side of a membrane to the other. IEA GO:0015087 cobalt ion transmembrane transporter activity GSVIVG01017866001 4127406 4132500 GO:0042773 ATP synthesis coupled electron transport The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP. IEA Catalysis of the transfer of cobalt (Co) ions from one side of a membrane to the other. IEA GO:0015087 cobalt ion transmembrane transporter activity GSVIVG01017866001 4127406 4132500 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the transfer of cobalt (Co) ions from one side of a membrane to the other. IEA GO:0015087 cobalt ion transmembrane transporter activity GSVIVG01016576001 2663188 2663841 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01016576001 2663188 2663841 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01016576001 2663188 2663841 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01016576001 2663188 2663841 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01016576001 2663188 2663841 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA IEA GO:0016986 transcription initiation factor activity GSVIVG01016576001 2663188 2663841 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA IEA GO:0016986 transcription initiation factor activity GSVIVG01016576001 2663188 2663841 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA IEA GO:0016986 transcription initiation factor activity GSVIVG01016576001 2663188 2663841 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA IEA GO:0016986 transcription initiation factor activity GSVIVG01031776001 4277143 4282861 GSVIVG01001357001 23905404 23933178 GO:0006777 Mo-molybdopterin cofactor biosynthetic process The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands. IEA GO:0019008 molybdopterin synthase complex A protein complex that possesses molybdopterin synthase activity. In E. coli, the complex is a heterotetramer consisting of two MoaD and two MoaE subunits. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001357001 23905404 23933178 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0019008 molybdopterin synthase complex A protein complex that possesses molybdopterin synthase activity. In E. coli, the complex is a heterotetramer consisting of two MoaD and two MoaE subunits. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001357001 23905404 23933178 GO:0006777 Mo-molybdopterin cofactor biosynthetic process The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands. IEA GO:0019008 molybdopterin synthase complex A protein complex that possesses molybdopterin synthase activity. In E. coli, the complex is a heterotetramer consisting of two MoaD and two MoaE subunits. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01001357001 23905404 23933178 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0019008 molybdopterin synthase complex A protein complex that possesses molybdopterin synthase activity. In E. coli, the complex is a heterotetramer consisting of two MoaD and two MoaE subunits. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01001357001 23905404 23933178 GO:0006777 Mo-molybdopterin cofactor biosynthetic process The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands. IEA GO:0019008 molybdopterin synthase complex A protein complex that possesses molybdopterin synthase activity. In E. coli, the complex is a heterotetramer consisting of two MoaD and two MoaE subunits. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01001357001 23905404 23933178 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0019008 molybdopterin synthase complex A protein complex that possesses molybdopterin synthase activity. In E. coli, the complex is a heterotetramer consisting of two MoaD and two MoaE subunits. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01001357001 23905404 23933178 GO:0006777 Mo-molybdopterin cofactor biosynthetic process The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands. IEA GO:0019008 molybdopterin synthase complex A protein complex that possesses molybdopterin synthase activity. In E. coli, the complex is a heterotetramer consisting of two MoaD and two MoaE subunits. IEA Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051539 4 iron, 4 sulfur cluster binding GSVIVG01001357001 23905404 23933178 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0019008 molybdopterin synthase complex A protein complex that possesses molybdopterin synthase activity. In E. coli, the complex is a heterotetramer consisting of two MoaD and two MoaE subunits. IEA Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051539 4 iron, 4 sulfur cluster binding GSVIVG01015230001 1980435 1984015 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01015230001 1980435 1984015 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01015230001 1980435 1984015 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01015230001 1980435 1984015 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01015230001 1980435 1984015 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01015230001 1980435 1984015 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01015230001 1980435 1984015 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01015230001 1980435 1984015 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01015479001 4046147 4052218 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01015479001 4046147 4052218 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01015479001 4046147 4052218 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01015479001 4046147 4052218 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01015479001 4046147 4052218 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01015479001 4046147 4052218 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01009287001 6993944 6998332 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01009287001 6993944 6998332 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01009287001 6993944 6998332 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the formation of a 2,3-epoxide in squalene. IEA GO:0004506 squalene monooxygenase activity GSVIVG01009287001 6993944 6998332 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the formation of a 2,3-epoxide in squalene. IEA GO:0004506 squalene monooxygenase activity GSVIVG01009287001 6993944 6998332 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01009287001 6993944 6998332 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01009287001 6993944 6998332 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01009287001 6993944 6998332 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01019134001 16349085 16351046 GSVIVG01016661001 197175 202354 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016661001 197175 202354 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01033664001 18830347 18833972 GO:0006189 'de novo' IMP biosynthetic process The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate. IEA Catalysis of the reaction: 10-formyltetrahydrofolate + H2O = formate + tetrahydrofolate. IEA GO:0008864 formyltetrahydrofolate deformylase activity GSVIVG01033664001 18830347 18833972 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 10-formyltetrahydrofolate + H2O = formate + tetrahydrofolate. IEA GO:0008864 formyltetrahydrofolate deformylase activity GSVIVG01033664001 18830347 18833972 GO:0006189 'de novo' IMP biosynthetic process The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate. IEA Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. IEA GO:0016597 amino acid binding GSVIVG01033664001 18830347 18833972 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. IEA GO:0016597 amino acid binding GSVIVG01015524001 4478527 4479944 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GSVIVG01013675001 2415958 2421027 GO:0030036 actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01013675001 2415958 2421027 GO:0030036 actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. IEA GO:0008290 F-actin capping protein complex A heterodimer consisting of alpha and beta subunits that binds to and caps the barbed ends of actin filaments, thereby regulating the polymerization of actin monomers but not severing actin filaments. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01005708001 21421869 21423037 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01005708001 21421869 21423037 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031505001 17837690 17845041 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01031505001 17837690 17845041 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031505001 17837690 17845041 Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01031505001 17837690 17845041 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01004279001 37932036 37933424 GSVIVG01026958001 19030849 19033997 GSVIVG01035419001 1166953 1170909 GO:0046907 intracellular transport The directed movement of substances within a cell. IEA GSVIVG01016926001 2652219 2656658 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01016926001 2652219 2656658 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01016926001 2652219 2656658 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01016926001 2652219 2656658 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016926001 2652219 2656658 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032636001 1966121 1976997 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. IEA GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GSVIVG01011454001 29772918 29777047 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01032965001 24652255 24655728 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01032965001 24652255 24655728 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01032965001 24652255 24655728 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01032965001 24652255 24655728 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01032965001 24652255 24655728 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032965001 24652255 24655728 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032965001 24652255 24655728 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032965001 24652255 24655728 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032965001 24652255 24655728 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01032965001 24652255 24655728 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01032965001 24652255 24655728 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01032965001 24652255 24655728 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01030178001 10808982 10818016 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01008186001 4889731 4906088 GO:0006171 cAMP biosynthetic process The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01008186001 4889731 4906088 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01008186001 4889731 4906088 GO:0006171 cAMP biosynthetic process The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). IEA Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate. IEA GO:0004016 adenylate cyclase activity GSVIVG01008186001 4889731 4906088 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate. IEA GO:0004016 adenylate cyclase activity GSVIVG01008186001 4889731 4906088 GO:0006171 cAMP biosynthetic process The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01008186001 4889731 4906088 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01008186001 4889731 4906088 GO:0006171 cAMP biosynthetic process The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01008186001 4889731 4906088 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01008186001 4889731 4906088 GO:0006171 cAMP biosynthetic process The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008186001 4889731 4906088 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008186001 4889731 4906088 GO:0006171 cAMP biosynthetic process The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01008186001 4889731 4906088 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01008186001 4889731 4906088 GO:0006171 cAMP biosynthetic process The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01008186001 4889731 4906088 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01009171001 5694493 5711399 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01009171001 5694493 5711399 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01005221001 19404069 19406518 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01005221001 19404069 19406518 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01022087001 16480730 16484246 GSVIVG01008204001 4709595 4710077 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01008845001 2745339 2754460 GO:0006081 cellular aldehyde metabolic process The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells. IEA Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+. IEA GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity GSVIVG01008845001 2745339 2754460 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+. IEA GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity GSVIVG01008845001 2745339 2754460 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+. IEA GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity GSVIVG01008845001 2745339 2754460 GO:0006081 cellular aldehyde metabolic process The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008845001 2745339 2754460 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008845001 2745339 2754460 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01026878001 19689714 19693047 GSVIVG01003220001 14045554 14050837 GSVIVG01007931001 7434851 7435273 GSVIVG01019462001 838383 848898 GSVIVG01033307001 21627959 21639845 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01033307001 21627959 21639845 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01023551001 9771968 9779302 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023551001 9771968 9779302 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023551001 9771968 9779302 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023551001 9771968 9779302 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023551001 9771968 9779302 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01023551001 9771968 9779302 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01021855001 6448491 6458277 GSVIVG01008277001 3695153 3700317 GSVIVG01001023001 20212881 20213432 GSVIVG01009279001 6912247 6918168 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020707001 2958962 2964574 GSVIVG01017656001 2410855 2411857 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01006614001 27044923 27049464 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01001293001 5116474 5116683 GSVIVG01032392001 26914733 26916386 GO:0042398 cellular amino acid derivative biosynthetic process The chemical reactions and pathways resulting in the formation of compounds derived from amino acids, organic acids containing one or more amino substituents. IEA The catalysis of certain rearrangements of a molecule to break or form a ring. IEA GO:0016872 intramolecular lyase activity GSVIVG01016076001 18462399 18484191 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with damaged DNA. IEA GO:0003684 damaged DNA binding GSVIVG01016076001 18462399 18484191 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with damaged DNA. IEA GO:0003684 damaged DNA binding GSVIVG01016076001 18462399 18484191 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with damaged DNA. IEA GO:0003684 damaged DNA binding GSVIVG01016076001 18462399 18484191 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with damaged DNA. IEA GO:0003684 damaged DNA binding GSVIVG01016076001 18462399 18484191 GO:0043161 proteasomal ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with damaged DNA. IEA GO:0003684 damaged DNA binding GSVIVG01016076001 18462399 18484191 GO:0043161 proteasomal ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with damaged DNA. IEA GO:0003684 damaged DNA binding GSVIVG01016076001 18462399 18484191 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01016076001 18462399 18484191 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01016076001 18462399 18484191 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01016076001 18462399 18484191 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01016076001 18462399 18484191 GO:0043161 proteasomal ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01016076001 18462399 18484191 GO:0043161 proteasomal ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01027946001 9854039 9862925 GSVIVG01029119001 19440584 19441700 GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026722001 5591586 5600893 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01026722001 5591586 5600893 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01038548001 21963904 21968096 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01018386001 9935686 9955418 GO:0048034 heme O biosynthetic process The chemical reactions and pathways resulting in the formation of heme O, a derivative of heme containing a 17-carbon hydroxyethylfarnesyl side chain at position 8 of the tetrapyrrole macrocycle. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor). IEA GO:0004659 prenyltransferase activity GSVIVG01018386001 9935686 9955418 GO:0048034 heme O biosynthetic process The chemical reactions and pathways resulting in the formation of heme O, a derivative of heme containing a 17-carbon hydroxyethylfarnesyl side chain at position 8 of the tetrapyrrole macrocycle. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA IEA GO:0008495 protoheme IX farnesyltransferase activity GSVIVG01007345001 31460966 31463816 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01007345001 31460966 31463816 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01007345001 31460966 31463816 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01007345001 31460966 31463816 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01028986001 16867341 16874670 GSVIVG01027831001 8298354 8300328 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01027831001 8298354 8300328 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01027831001 8298354 8300328 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01027831001 8298354 8300328 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034499001 20267070 20299113 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01034499001 20267070 20299113 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01034499001 20267070 20299113 Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 5' end. IEA GO:0008409 5'-3' exonuclease activity GSVIVG01029949001 2012164 2020389 GO:0016070 RNA metabolic process The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01029949001 2012164 2020389 GO:0016070 RNA metabolic process The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01019020001 17661359 17664518 GSVIVG01014239001 1821686 1826845 GSVIVG01025640001 13410496 13412625 GSVIVG01017317001 6683710 6685577 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031126001 1915897 1918892 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01031126001 1915897 1918892 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01031126001 1915897 1918892 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01031126001 1915897 1918892 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01031126001 1915897 1918892 GO:0016043 cellular component organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cellular component. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01031126001 1915897 1918892 GO:0016043 cellular component organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cellular component. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01031126001 1915897 1918892 GO:0030036 actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01031126001 1915897 1918892 GO:0030036 actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01031126001 1915897 1918892 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01031126001 1915897 1918892 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01031126001 1915897 1918892 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01031126001 1915897 1918892 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01031126001 1915897 1918892 GO:0016043 cellular component organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cellular component. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01031126001 1915897 1918892 GO:0016043 cellular component organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cellular component. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01031126001 1915897 1918892 GO:0030036 actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01031126001 1915897 1918892 GO:0030036 actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01031126001 1915897 1918892 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA The action of a molecule that contributes to the structural integrity of a cell wall. IEA GO:0005199 structural constituent of cell wall GSVIVG01031126001 1915897 1918892 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The action of a molecule that contributes to the structural integrity of a cell wall. IEA GO:0005199 structural constituent of cell wall GSVIVG01031126001 1915897 1918892 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA The action of a molecule that contributes to the structural integrity of a cell wall. IEA GO:0005199 structural constituent of cell wall GSVIVG01031126001 1915897 1918892 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The action of a molecule that contributes to the structural integrity of a cell wall. IEA GO:0005199 structural constituent of cell wall GSVIVG01031126001 1915897 1918892 GO:0016043 cellular component organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cellular component. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA The action of a molecule that contributes to the structural integrity of a cell wall. IEA GO:0005199 structural constituent of cell wall GSVIVG01031126001 1915897 1918892 GO:0016043 cellular component organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cellular component. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The action of a molecule that contributes to the structural integrity of a cell wall. IEA GO:0005199 structural constituent of cell wall GSVIVG01031126001 1915897 1918892 GO:0030036 actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA The action of a molecule that contributes to the structural integrity of a cell wall. IEA GO:0005199 structural constituent of cell wall GSVIVG01031126001 1915897 1918892 GO:0030036 actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The action of a molecule that contributes to the structural integrity of a cell wall. IEA GO:0005199 structural constituent of cell wall GSVIVG01009858001 11862551 11869310 GSVIVG01027128001 17609529 17610498 GSVIVG01033234001 22335198 22337122 GSVIVG01013609001 1329471 1334628 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01013609001 1329471 1334628 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037575001 10835007 10839521 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01037575001 10835007 10839521 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01037575001 10835007 10839521 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01037575001 10835007 10839521 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01037575001 10835007 10839521 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01037575001 10835007 10839521 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01031414001 18863017 18873487 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01012731001 1076042 1081337 GSVIVG01035120001 1593981 1599561 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01035120001 1593981 1599561 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01030918001 18982127 18982610 GSVIVG01038396001 11710743 11712261 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01005149001 18589349 18590826 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GSVIVG01036937001 17315924 17324687 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01020146001 9872291 9873600 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01020146001 9872291 9873600 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01035046001 1144680 1145755 GSVIVG01000710001 54208 55617 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000710001 54208 55617 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000710001 54208 55617 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000710001 54208 55617 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01000710001 54208 55617 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01000710001 54208 55617 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01000710001 54208 55617 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01000710001 54208 55617 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01000710001 54208 55617 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01000710001 54208 55617 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01000710001 54208 55617 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01000710001 54208 55617 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01007889001 7901600 7907555 GSVIVG01013024001 10033049 10045349 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013024001 10033049 10045349 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01013129001 7886692 7889892 GSVIVG01014685001 8601631 8609299 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01017055001 3821590 3824309 GSVIVG01034285001 14071360 14071715 GSVIVG01021193001 2459108 2461267 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01021193001 2459108 2461267 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01014967001 13198349 13202468 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01014967001 13198349 13202468 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01014967001 13198349 13202468 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01014967001 13198349 13202468 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01013883001 5976195 5979655 GSVIVG01004111001 14919250 14932495 GO:0032313 regulation of Rab GTPase activity Any process that modulates the activity of a GTPase of the Rab family. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Increases the rate of GTP hydrolysis by a GTPase of the Rab family. IEA GO:0005097 Rab GTPase activator activity GSVIVG01022361001 18988799 18996404 GSVIVG01017510001 9675812 9677470 GSVIVG01019988001 11949627 11958474 GSVIVG01032195001 21632041 21686570 GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01032195001 21632041 21686570 GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032195001 21632041 21686570 GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01029355001 15114055 15127169 GO:0032312 regulation of ARF GTPase activity Any process that modulates the activity of the GTPase ARF. IEA Increases the rate of GTP hydrolysis by the GTPase ARF. IEA GO:0008060 ARF GTPase activator activity GSVIVG01029355001 15114055 15127169 GO:0032312 regulation of ARF GTPase activity Any process that modulates the activity of the GTPase ARF. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01015304001 2518467 2520621 GSVIVG01028623001 10985972 10986760 GSVIVG01020993001 15855335 15863727 GSVIVG01014473001 4224220 4232990 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014473001 4224220 4232990 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014473001 4224220 4232990 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014473001 4224220 4232990 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014473001 4224220 4232990 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014473001 4224220 4232990 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014473001 4224220 4232990 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014473001 4224220 4232990 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001828001 26134493 26140331 GSVIVG01036261001 7864212 7868722 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01036261001 7864212 7868722 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036261001 7864212 7868722 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01009083001 4806872 4808947 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01009083001 4806872 4808947 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01009083001 4806872 4808947 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01009083001 4806872 4808947 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01009083001 4806872 4808947 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01009083001 4806872 4808947 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01009083001 4806872 4808947 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01009083001 4806872 4808947 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01034775001 21219651 21220463 GSVIVG01034164001 14729949 14730675 GSVIVG01023703001 9616505 9617799 GO:0006541 glutamine metabolic process The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01023703001 9616505 9617799 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01022190001 17310943 17317760 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01024163001 671036 676607 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GSVIVG01024163001 671036 676607 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GSVIVG01014152001 869587 883359 GSVIVG01025301001 2295699 2298207 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01023054001 16241432 16243850 Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01023054001 16241432 16243850 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01011138001 7109736 7110548 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01011138001 7109736 7110548 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01027649001 14654798 14664698 GSVIVG01015022001 521622 524349 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the reaction: pectin + n H2O = n methanol + pectate. IEA GO:0030599 pectinesterase activity GSVIVG01014088001 278703 280954 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01029372001 15631827 15634248 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01029372001 15631827 15634248 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01029372001 15631827 15634248 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01029372001 15631827 15634248 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01029372001 15631827 15634248 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01029372001 15631827 15634248 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01029372001 15631827 15634248 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01029372001 15631827 15634248 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01033792001 17800315 17802467 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01032199001 21601517 21610881 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032199001 21601517 21610881 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032199001 21601517 21610881 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032199001 21601517 21610881 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030886001 18358847 18385795 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030886001 18358847 18385795 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030886001 18358847 18385795 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA Catalysis of the reaction: 10-formyltetrahydrofolate + L-methionyl-tRNA + H2O = tetrahydrofolate + N-formylmethionyl-tRNA. IEA GO:0004479 methionyl-tRNA formyltransferase activity GSVIVG01030886001 18358847 18385795 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: 10-formyltetrahydrofolate + L-methionyl-tRNA + H2O = tetrahydrofolate + N-formylmethionyl-tRNA. IEA GO:0004479 methionyl-tRNA formyltransferase activity GSVIVG01030886001 18358847 18385795 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA IEA GO:0016742 hydroxymethyl-, formyl- and related transferase activity GSVIVG01030886001 18358847 18385795 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA IEA GO:0016742 hydroxymethyl-, formyl- and related transferase activity GSVIVG01001815001 26032901 26038531 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01001815001 26032901 26038531 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01001815001 26032901 26038531 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01001815001 26032901 26038531 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01001815001 26032901 26038531 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024656001 7983729 7985909 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01001707001 12486815 12487788 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01023461001 11516788 11520418 GSVIVG01013870001 5710447 5714641 GSVIVG01032785001 782570 793285 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01032785001 782570 793285 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01032785001 782570 793285 GO:0006829 zinc ion transport The directed movement of zinc (Zn) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01032785001 782570 793285 GO:0006829 zinc ion transport The directed movement of zinc (Zn) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01032785001 782570 793285 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01032785001 782570 793285 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01032785001 782570 793285 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01032785001 782570 793285 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01032785001 782570 793285 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01032785001 782570 793285 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01032785001 782570 793285 GO:0006829 zinc ion transport The directed movement of zinc (Zn) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01032785001 782570 793285 GO:0006829 zinc ion transport The directed movement of zinc (Zn) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01032785001 782570 793285 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01032785001 782570 793285 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01032785001 782570 793285 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01032785001 782570 793285 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01032785001 782570 793285 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. IEA GO:0005385 zinc ion transmembrane transporter activity GSVIVG01032785001 782570 793285 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. IEA GO:0005385 zinc ion transmembrane transporter activity GSVIVG01032785001 782570 793285 GO:0006829 zinc ion transport The directed movement of zinc (Zn) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. IEA GO:0005385 zinc ion transmembrane transporter activity GSVIVG01032785001 782570 793285 GO:0006829 zinc ion transport The directed movement of zinc (Zn) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. IEA GO:0005385 zinc ion transmembrane transporter activity GSVIVG01032785001 782570 793285 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. IEA GO:0005385 zinc ion transmembrane transporter activity GSVIVG01032785001 782570 793285 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. IEA GO:0005385 zinc ion transmembrane transporter activity GSVIVG01032785001 782570 793285 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. IEA GO:0005385 zinc ion transmembrane transporter activity GSVIVG01032785001 782570 793285 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. IEA GO:0005385 zinc ion transmembrane transporter activity GSVIVG01032785001 782570 793285 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01032785001 782570 793285 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01032785001 782570 793285 GO:0006829 zinc ion transport The directed movement of zinc (Zn) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01032785001 782570 793285 GO:0006829 zinc ion transport The directed movement of zinc (Zn) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01032785001 782570 793285 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01032785001 782570 793285 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01032785001 782570 793285 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01032785001 782570 793285 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01008693001 1249392 1252271 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01037158001 28461772 28464940 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01001658001 14002488 14002937 GSVIVG01020937001 16854402 16867092 GSVIVG01011956001 2651808 2665672 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01011956001 2651808 2665672 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01026435001 23633365 23642678 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01033780001 17882517 17883688 GSVIVG01014413001 3543606 3544316 GSVIVG01014420001 3606189 3608810 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01014420001 3606189 3608810 Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01027013001 18572294 18573190 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027013001 18572294 18573190 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01027013001 18572294 18573190 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01013797001 7494007 7502229 GO:0006306 DNA methylation The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01013797001 7494007 7502229 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01013797001 7494007 7502229 GO:0006306 DNA methylation The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01013797001 7494007 7502229 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01013797001 7494007 7502229 GO:0006306 DNA methylation The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. IEA Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule. IEA GO:0008170 N-methyltransferase activity GSVIVG01013797001 7494007 7502229 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule. IEA GO:0008170 N-methyltransferase activity GSVIVG01011414001 29469396 29471423 GSVIVG01026496001 22650480 22698343 GO:0046854 phosphoinositide phosphorylation The process of introducing one or more phosphate groups into a phosphoinositide, a class of substances comprising phosphatidylinositol and its derivatives. IEA Catalysis of the phosphorylation of myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol. IEA GO:0004428 inositol or phosphatidylinositol kinase activity GSVIVG01026496001 22650480 22698343 GO:0048015 phosphoinositide-mediated signaling A series of molecular signals in which a cell uses a phosphoinositide to convert an extracellular signal into a response. IEA Catalysis of the phosphorylation of myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol. IEA GO:0004428 inositol or phosphatidylinositol kinase activity GSVIVG01026496001 22650480 22698343 GO:0046854 phosphoinositide phosphorylation The process of introducing one or more phosphate groups into a phosphoinositide, a class of substances comprising phosphatidylinositol and its derivatives. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026496001 22650480 22698343 GO:0048015 phosphoinositide-mediated signaling A series of molecular signals in which a cell uses a phosphoinositide to convert an extracellular signal into a response. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026496001 22650480 22698343 GO:0046854 phosphoinositide phosphorylation The process of introducing one or more phosphate groups into a phosphoinositide, a class of substances comprising phosphatidylinositol and its derivatives. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01026496001 22650480 22698343 GO:0048015 phosphoinositide-mediated signaling A series of molecular signals in which a cell uses a phosphoinositide to convert an extracellular signal into a response. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01020255001 22201586 22201893 GSVIVG01019771001 3194241 3196516 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01017023001 3523320 3527059 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017023001 3523320 3527059 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016813001 1618166 1619285 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01003446001 10067567 10068699 GSVIVG01012508001 233813 237546 GO:0009416 response to light stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01012508001 233813 237546 GO:0009416 response to light stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018387001 9917604 9919332 GSVIVG01036284001 3380476 3382560 GO:0006777 Mo-molybdopterin cofactor biosynthetic process The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands. IEA GSVIVG01036284001 3380476 3382560 GO:0006790 sulfur metabolic process The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione. IEA GSVIVG01001261001 4885464 4886006 GSVIVG01038274001 24881205 24884114 GSVIVG01015543001 4701210 4707836 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01005831001 349761 350078 GSVIVG01034844001 22552355 22552665 GSVIVG01018554001 13468258 13469484 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018554001 13468258 13469484 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018554001 13468258 13469484 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01018554001 13468258 13469484 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01018554001 13468258 13469484 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01018554001 13468258 13469484 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01019943001 12671769 12677262 GSVIVG01005721001 21624445 21625408 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01007265001 31128733 31128954 GSVIVG01011008001 2256656 2262296 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01011008001 2256656 2262296 GO:0009725 response to hormone stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01011008001 2256656 2262296 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01011008001 2256656 2262296 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01011008001 2256656 2262296 GO:0009725 response to hormone stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01011008001 2256656 2262296 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01029885001 932785 935082 GSVIVG01027515001 16031370 16036814 GSVIVG01036709001 23490155 23490538 GSVIVG01026471001 23029803 23039786 GO:0006790 sulfur metabolic process The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione. IEA Catalysis of the removal of a phosphate group from phosphorylated myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol. IEA GO:0004437 inositol or phosphatidylinositol phosphatase activity GSVIVG01026471001 23029803 23039786 GO:0006790 sulfur metabolic process The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione. IEA Catalysis of the reaction: adenosine 3',5'-bisphosphate + H2O = adenosine 5'-phosphate + phosphate. IEA GO:0008441 3'(2'),5'-bisphosphate nucleotidase activity GSVIVG01033433001 20720779 20724328 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033433001 20720779 20724328 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01009711001 10677981 10681418 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01030032001 9004491 9005338 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01021675001 9133901 9140217 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01005090001 14421296 14427727 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01005090001 14421296 14427727 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01005090001 14421296 14427727 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01005090001 14421296 14427727 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01005090001 14421296 14427727 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate. IEA GO:0019001 guanyl nucleotide binding GSVIVG01005090001 14421296 14427727 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate. IEA GO:0019001 guanyl nucleotide binding GSVIVG01012463001 1214371 1222287 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function that links a sequence-specific transcription factor to the core RNA polymerase II complex but does not bind DNA itself. IEA GO:0003712 transcription cofactor activity GSVIVG01012463001 1214371 1222287 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01021358001 4421896 4427962 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01036952001 17046630 17048115 GSVIVG01034226001 13036098 13054499 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01034226001 13036098 13054499 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01022836001 18928749 18935983 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020608001 3804271 3807856 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01020608001 3804271 3807856 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038031001 16531632 16532867 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. IEA GO:0004364 glutathione transferase activity GSVIVG01018339001 10802899 10807025 GSVIVG01019759001 3050038 3064290 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01019759001 3050038 3064290 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01019759001 3050038 3064290 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01019759001 3050038 3064290 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019759001 3050038 3064290 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015375001 3108853 3113767 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA Catalysis of the transfer of the amide nitrogen of glutamine to a variety of substrates. GATases catalyze two separate reactions at two active sites, which are located either on a single polypeptide chain or on different subunits. In the glutaminase reaction, glutamine is hydrolyzed to glutamate and ammonia, which is added to an acceptor substrate in the synthase reaction. IEA GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor GSVIVG01009121001 5266543 5272067 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01009121001 5266543 5272067 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01009121001 5266543 5272067 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01009121001 5266543 5272067 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01009121001 5266543 5272067 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015040001 668977 676542 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01015040001 668977 676542 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01000278001 20986938 20987875 GSVIVG01005333001 39692787 39692999 GSVIVG01006591001 26910348 26913498 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01006591001 26910348 26913498 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01023203001 21182448 21194571 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023203001 21182448 21194571 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023203001 21182448 21194571 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023203001 21182448 21194571 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023203001 21182448 21194571 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023203001 21182448 21194571 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023203001 21182448 21194571 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01023203001 21182448 21194571 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01026108001 24495778 24495942 GSVIVG01008483001 1487787 1491499 GO:0006542 glutamine biosynthetic process The chemical reactions and pathways resulting in the formation of glutamine, 2-amino-4-carbamoylbutanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01008483001 1487787 1491499 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01008483001 1487787 1491499 GO:0006542 glutamine biosynthetic process The chemical reactions and pathways resulting in the formation of glutamine, 2-amino-4-carbamoylbutanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008483001 1487787 1491499 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008483001 1487787 1491499 GO:0006542 glutamine biosynthetic process The chemical reactions and pathways resulting in the formation of glutamine, 2-amino-4-carbamoylbutanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine. IEA GO:0004356 glutamate-ammonia ligase activity GSVIVG01008483001 1487787 1491499 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine. IEA GO:0004356 glutamate-ammonia ligase activity GSVIVG01008483001 1487787 1491499 GO:0006542 glutamine biosynthetic process The chemical reactions and pathways resulting in the formation of glutamine, 2-amino-4-carbamoylbutanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008483001 1487787 1491499 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008483001 1487787 1491499 GO:0006542 glutamine biosynthetic process The chemical reactions and pathways resulting in the formation of glutamine, 2-amino-4-carbamoylbutanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01008483001 1487787 1491499 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01030992001 20429728 20435382 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01030992001 20429728 20435382 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01030992001 20429728 20435382 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000987001 11149541 11150786 GSVIVG01001378001 24104117 24105370 GSVIVG01017665001 2482793 2484238 GSVIVG01037608001 6217098 6219801 GSVIVG01003627001 491380 504880 GSVIVG01019032001 17564079 17565725 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01019032001 17564079 17565725 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01013687001 2632579 2645110 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01013687001 2632579 2645110 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01013182001 7008154 7010602 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01028050001 3447101 3448478 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01028050001 3447101 3448478 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01002076001 32740380 32743620 GSVIVG01037922001 6314642 6315822 GSVIVG01033025001 25152912 25178448 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01017648001 2361512 2376608 GSVIVG01029728001 13793065 13793880 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01007871001 8143215 8144054 GSVIVG01017780001 3426744 3427316 GSVIVG01028863001 18020282 18021197 GSVIVG01027100001 17940947 17944311 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01027100001 17940947 17944311 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022074001 16377832 16385165 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01022074001 16377832 16385165 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01000917001 21888059 21891236 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. IEA GO:0016597 amino acid binding GSVIVG01020148001 9806363 9818398 GSVIVG01038178001 24094752 24103823 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01038178001 24094752 24103823 GO:0006535 cysteine biosynthetic process from serine The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01038178001 24094752 24103823 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01038178001 24094752 24103823 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01038178001 24094752 24103823 GO:0019344 cysteine biosynthetic process The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01038178001 24094752 24103823 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01038178001 24094752 24103823 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the reaction: O3-acetyl-L-serine + H2S = L-cysteine + acetate. IEA GO:0004124 cysteine synthase activity GSVIVG01038178001 24094752 24103823 GO:0006535 cysteine biosynthetic process from serine The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine. IEA Catalysis of the reaction: O3-acetyl-L-serine + H2S = L-cysteine + acetate. IEA GO:0004124 cysteine synthase activity GSVIVG01038178001 24094752 24103823 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: O3-acetyl-L-serine + H2S = L-cysteine + acetate. IEA GO:0004124 cysteine synthase activity GSVIVG01038178001 24094752 24103823 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the reaction: O3-acetyl-L-serine + H2S = L-cysteine + acetate. IEA GO:0004124 cysteine synthase activity GSVIVG01038178001 24094752 24103823 GO:0019344 cysteine biosynthetic process The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid. IEA Catalysis of the reaction: O3-acetyl-L-serine + H2S = L-cysteine + acetate. IEA GO:0004124 cysteine synthase activity GSVIVG01038178001 24094752 24103823 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: O3-acetyl-L-serine + H2S = L-cysteine + acetate. IEA GO:0004124 cysteine synthase activity GSVIVG01038178001 24094752 24103823 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01038178001 24094752 24103823 GO:0006535 cysteine biosynthetic process from serine The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01038178001 24094752 24103823 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01038178001 24094752 24103823 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01038178001 24094752 24103823 GO:0019344 cysteine biosynthetic process The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01038178001 24094752 24103823 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01038178001 24094752 24103823 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01038178001 24094752 24103823 GO:0006535 cysteine biosynthetic process from serine The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01038178001 24094752 24103823 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01038178001 24094752 24103823 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01038178001 24094752 24103823 GO:0019344 cysteine biosynthetic process The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01038178001 24094752 24103823 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01038178001 24094752 24103823 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01038178001 24094752 24103823 GO:0006535 cysteine biosynthetic process from serine The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01038178001 24094752 24103823 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01038178001 24094752 24103823 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01038178001 24094752 24103823 GO:0019344 cysteine biosynthetic process The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01038178001 24094752 24103823 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01038178001 24094752 24103823 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01038178001 24094752 24103823 GO:0006535 cysteine biosynthetic process from serine The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01038178001 24094752 24103823 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01038178001 24094752 24103823 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01038178001 24094752 24103823 GO:0019344 cysteine biosynthetic process The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01038178001 24094752 24103823 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01035745001 3865122 3866244 GSVIVG01027662001 14534520 14540309 Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amidine, a compound of the form R-C(=NH)-NH2. IEA GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines GSVIVG01027662001 14534520 14540309 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01027676001 14448633 14469479 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027676001 14448633 14469479 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01013803001 7420883 7423276 GSVIVG01027661001 14543455 14547036 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001337001 447913 450180 GSVIVG01004064001 619530 623825 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01004064001 619530 623825 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01004064001 619530 623825 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01004064001 619530 623825 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034825001 22217638 22217847 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01015224001 1954285 1955305 GSVIVG01008289001 3612190 3618035 GSVIVG01025765001 12123340 12123600 GSVIVG01014529001 4851075 4855125 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014529001 4851075 4855125 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014529001 4851075 4855125 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014529001 4851075 4855125 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014529001 4851075 4855125 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014529001 4851075 4855125 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014529001 4851075 4855125 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014529001 4851075 4855125 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014529001 4851075 4855125 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01014529001 4851075 4855125 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01016946001 2847686 2856800 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01016946001 2847686 2856800 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01016946001 2847686 2856800 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01016946001 2847686 2856800 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034582001 19080415 19085513 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01034582001 19080415 19085513 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01034582001 19080415 19085513 GO:0006527 arginine catabolic process The chemical reactions and pathways resulting in the breakdown of arginine, 2-amino-5-(carbamimidamido)pentanoic acid. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01034582001 19080415 19085513 GO:0006527 arginine catabolic process The chemical reactions and pathways resulting in the breakdown of arginine, 2-amino-5-(carbamimidamido)pentanoic acid. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01034582001 19080415 19085513 GO:0008295 spermidine biosynthetic process The chemical reactions and pathways resulting in the formation of spermidine, N-(3-aminopropyl)-1,4-diaminobutane. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01034582001 19080415 19085513 GO:0008295 spermidine biosynthetic process The chemical reactions and pathways resulting in the formation of spermidine, N-(3-aminopropyl)-1,4-diaminobutane. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01034582001 19080415 19085513 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01034582001 19080415 19085513 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01034582001 19080415 19085513 GO:0006527 arginine catabolic process The chemical reactions and pathways resulting in the breakdown of arginine, 2-amino-5-(carbamimidamido)pentanoic acid. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01034582001 19080415 19085513 GO:0006527 arginine catabolic process The chemical reactions and pathways resulting in the breakdown of arginine, 2-amino-5-(carbamimidamido)pentanoic acid. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01034582001 19080415 19085513 GO:0008295 spermidine biosynthetic process The chemical reactions and pathways resulting in the formation of spermidine, N-(3-aminopropyl)-1,4-diaminobutane. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01034582001 19080415 19085513 GO:0008295 spermidine biosynthetic process The chemical reactions and pathways resulting in the formation of spermidine, N-(3-aminopropyl)-1,4-diaminobutane. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01034582001 19080415 19085513 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01034582001 19080415 19085513 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01034582001 19080415 19085513 GO:0006527 arginine catabolic process The chemical reactions and pathways resulting in the breakdown of arginine, 2-amino-5-(carbamimidamido)pentanoic acid. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01034582001 19080415 19085513 GO:0006527 arginine catabolic process The chemical reactions and pathways resulting in the breakdown of arginine, 2-amino-5-(carbamimidamido)pentanoic acid. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01034582001 19080415 19085513 GO:0008295 spermidine biosynthetic process The chemical reactions and pathways resulting in the formation of spermidine, N-(3-aminopropyl)-1,4-diaminobutane. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01034582001 19080415 19085513 GO:0008295 spermidine biosynthetic process The chemical reactions and pathways resulting in the formation of spermidine, N-(3-aminopropyl)-1,4-diaminobutane. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01034582001 19080415 19085513 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: L-arginine = agmatine + CO2. IEA GO:0008792 arginine decarboxylase activity GSVIVG01034582001 19080415 19085513 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Catalysis of the reaction: L-arginine = agmatine + CO2. IEA GO:0008792 arginine decarboxylase activity GSVIVG01034582001 19080415 19085513 GO:0006527 arginine catabolic process The chemical reactions and pathways resulting in the breakdown of arginine, 2-amino-5-(carbamimidamido)pentanoic acid. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: L-arginine = agmatine + CO2. IEA GO:0008792 arginine decarboxylase activity GSVIVG01034582001 19080415 19085513 GO:0006527 arginine catabolic process The chemical reactions and pathways resulting in the breakdown of arginine, 2-amino-5-(carbamimidamido)pentanoic acid. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Catalysis of the reaction: L-arginine = agmatine + CO2. IEA GO:0008792 arginine decarboxylase activity GSVIVG01034582001 19080415 19085513 GO:0008295 spermidine biosynthetic process The chemical reactions and pathways resulting in the formation of spermidine, N-(3-aminopropyl)-1,4-diaminobutane. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: L-arginine = agmatine + CO2. IEA GO:0008792 arginine decarboxylase activity GSVIVG01034582001 19080415 19085513 GO:0008295 spermidine biosynthetic process The chemical reactions and pathways resulting in the formation of spermidine, N-(3-aminopropyl)-1,4-diaminobutane. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Catalysis of the reaction: L-arginine = agmatine + CO2. IEA GO:0008792 arginine decarboxylase activity GSVIVG01000428001 7856363 7859726 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01000428001 7856363 7859726 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01000428001 7856363 7859726 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01000428001 7856363 7859726 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01000428001 7856363 7859726 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01000428001 7856363 7859726 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01000428001 7856363 7859726 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000428001 7856363 7859726 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026022001 25750623 25752134 GSVIVG01024203001 341582 357538 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01024203001 341582 357538 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01024203001 341582 357538 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024203001 341582 357538 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008220001 4521710 4522460 Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01008220001 4521710 4522460 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01029523001 22010060 22017455 GSVIVG01027188001 17156386 17165344 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027188001 17156386 17165344 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027188001 17156386 17165344 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01027188001 17156386 17165344 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01027188001 17156386 17165344 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01027188001 17156386 17165344 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01024007001 1776069 1776780 Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01024007001 1776069 1776780 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01001784001 3076729 3078280 GSVIVG01003422001 14857127 14867443 GSVIVG01037420001 14100852 14107449 GO:0006397 mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity. IEA GO:0004721 phosphoprotein phosphatase activity GSVIVG01037420001 14100852 14107449 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity. IEA GO:0004721 phosphoprotein phosphatase activity GSVIVG01037420001 14100852 14107449 GO:0006397 mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. IEA GO:0004725 protein tyrosine phosphatase activity GSVIVG01037420001 14100852 14107449 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. IEA GO:0004725 protein tyrosine phosphatase activity GSVIVG01025968001 26481482 26486472 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01025968001 26481482 26486472 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01025968001 26481482 26486472 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01025968001 26481482 26486472 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01025968001 26481482 26486472 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01025968001 26481482 26486472 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01025968001 26481482 26486472 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01025968001 26481482 26486472 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01025968001 26481482 26486472 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01025968001 26481482 26486472 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01025968001 26481482 26486472 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01025968001 26481482 26486472 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01025968001 26481482 26486472 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01025968001 26481482 26486472 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01025968001 26481482 26486472 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01025968001 26481482 26486472 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025968001 26481482 26486472 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025968001 26481482 26486472 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025968001 26481482 26486472 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025968001 26481482 26486472 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025968001 26481482 26486472 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025968001 26481482 26486472 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025968001 26481482 26486472 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025968001 26481482 26486472 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025968001 26481482 26486472 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025968001 26481482 26486472 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01025968001 26481482 26486472 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01025968001 26481482 26486472 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01025968001 26481482 26486472 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01025968001 26481482 26486472 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01026059001 25114030 25167162 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01026059001 25114030 25167162 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01026059001 25114030 25167162 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01026059001 25114030 25167162 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01026059001 25114030 25167162 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01026059001 25114030 25167162 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01024833001 6553167 6562138 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01024833001 6553167 6562138 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01024833001 6553167 6562138 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01024833001 6553167 6562138 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024833001 6553167 6562138 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029202001 18601310 18603161 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01029202001 18601310 18603161 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029202001 18601310 18603161 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01001395001 24198807 24201629 GSVIVG01035372001 855196 855690 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01035372001 855196 855690 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035372001 855196 855690 Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01017002001 3368517 3369797 GSVIVG01028152001 4239432 4246879 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01017034001 3665119 3666208 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01017034001 3665119 3666208 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01020206001 9040526 9082810 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020206001 9040526 9082810 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020206001 9040526 9082810 GO:0006435 threonyl-tRNA aminoacylation The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020206001 9040526 9082810 GO:0043039 tRNA aminoacylation The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020206001 9040526 9082810 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01020206001 9040526 9082810 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01020206001 9040526 9082810 GO:0006435 threonyl-tRNA aminoacylation The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01020206001 9040526 9082810 GO:0043039 tRNA aminoacylation The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01020206001 9040526 9082810 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr). IEA GO:0004829 threonine-tRNA ligase activity GSVIVG01020206001 9040526 9082810 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr). IEA GO:0004829 threonine-tRNA ligase activity GSVIVG01020206001 9040526 9082810 GO:0006435 threonyl-tRNA aminoacylation The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr). IEA GO:0004829 threonine-tRNA ligase activity GSVIVG01020206001 9040526 9082810 GO:0043039 tRNA aminoacylation The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr). IEA GO:0004829 threonine-tRNA ligase activity GSVIVG01020206001 9040526 9082810 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020206001 9040526 9082810 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020206001 9040526 9082810 GO:0006435 threonyl-tRNA aminoacylation The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020206001 9040526 9082810 GO:0043039 tRNA aminoacylation The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020206001 9040526 9082810 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances via a carbon-oxygen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate, to form aminoacyl-tRNA or a related compound. IEA GO:0016876 ligase activity, forming aminoacyl-tRNA and related compounds GSVIVG01020206001 9040526 9082810 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances via a carbon-oxygen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate, to form aminoacyl-tRNA or a related compound. IEA GO:0016876 ligase activity, forming aminoacyl-tRNA and related compounds GSVIVG01020206001 9040526 9082810 GO:0006435 threonyl-tRNA aminoacylation The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances via a carbon-oxygen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate, to form aminoacyl-tRNA or a related compound. IEA GO:0016876 ligase activity, forming aminoacyl-tRNA and related compounds GSVIVG01020206001 9040526 9082810 GO:0043039 tRNA aminoacylation The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances via a carbon-oxygen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate, to form aminoacyl-tRNA or a related compound. IEA GO:0016876 ligase activity, forming aminoacyl-tRNA and related compounds GSVIVG01018931001 18558542 18561055 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01007901001 7756998 7761593 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01000116001 15390644 15395837 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01000116001 15390644 15395837 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01000116001 15390644 15395837 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01000116001 15390644 15395837 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000116001 15390644 15395837 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000116001 15390644 15395837 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000116001 15390644 15395837 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of calcium (Ca) ions from one side of a membrane to the other. IEA GO:0015085 calcium ion transmembrane transporter activity GSVIVG01000116001 15390644 15395837 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of calcium (Ca) ions from one side of a membrane to the other. IEA GO:0015085 calcium ion transmembrane transporter activity GSVIVG01000116001 15390644 15395837 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of calcium (Ca) ions from one side of a membrane to the other. IEA GO:0015085 calcium ion transmembrane transporter activity GSVIVG01000116001 15390644 15395837 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01000116001 15390644 15395837 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01000116001 15390644 15395837 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01000116001 15390644 15395837 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01000116001 15390644 15395837 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01000116001 15390644 15395837 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01023120001 22359026 22360709 GSVIVG01000230001 20130225 20131820 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GSVIVG01012895001 6576324 6581862 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01012895001 6576324 6581862 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01012895001 6576324 6581862 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01012895001 6576324 6581862 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023948001 2246284 2248846 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0031227 intrinsic to endoplasmic reticulum membrane Located in the endoplasmic reticulum membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01023948001 2246284 2248846 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0031227 intrinsic to endoplasmic reticulum membrane Located in the endoplasmic reticulum membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01023948001 2246284 2248846 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0031227 intrinsic to endoplasmic reticulum membrane Located in the endoplasmic reticulum membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01009052001 4564027 4586046 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01021365001 4494206 4505281 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01021365001 4494206 4505281 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01021365001 4494206 4505281 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01021365001 4494206 4505281 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01021365001 4494206 4505281 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021365001 4494206 4505281 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021365001 4494206 4505281 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021365001 4494206 4505281 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021365001 4494206 4505281 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01021365001 4494206 4505281 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01021365001 4494206 4505281 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01021365001 4494206 4505281 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01021365001 4494206 4505281 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01021365001 4494206 4505281 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01021365001 4494206 4505281 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01021365001 4494206 4505281 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01021365001 4494206 4505281 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01021365001 4494206 4505281 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01021365001 4494206 4505281 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01021365001 4494206 4505281 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01004800001 5665 13095 GSVIVG01006097001 41422791 41423006 GSVIVG01009925001 12453624 12456717 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0042651 thylakoid membrane The pigmented membrane of any thylakoid. IEA Catalysis of the reaction: reduced ferredoxin + NADP+ = oxidized ferredoxin + NADPH + H+. IEA GO:0004324 ferredoxin-NADP+ reductase activity GSVIVG01009925001 12453624 12456717 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0042651 thylakoid membrane The pigmented membrane of any thylakoid. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01009925001 12453624 12456717 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0042651 thylakoid membrane The pigmented membrane of any thylakoid. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01009925001 12453624 12456717 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0042651 thylakoid membrane The pigmented membrane of any thylakoid. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01029397001 16245900 16246154 GSVIVG01017174001 5008809 5010244 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01017174001 5008809 5010244 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01007950001 7253255 7253956 GSVIVG01036965001 9452229 9454982 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01036965001 9452229 9454982 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01036965001 9452229 9454982 GO:0006099 tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01036965001 9452229 9454982 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01036965001 9452229 9454982 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01036965001 9452229 9454982 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01036965001 9452229 9454982 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01036965001 9452229 9454982 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01036965001 9452229 9454982 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01036965001 9452229 9454982 GO:0006099 tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01036965001 9452229 9454982 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01036965001 9452229 9454982 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01036965001 9452229 9454982 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01036965001 9452229 9454982 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01036965001 9452229 9454982 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01036965001 9452229 9454982 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01036965001 9452229 9454982 GO:0006099 tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01036965001 9452229 9454982 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01036965001 9452229 9454982 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01036965001 9452229 9454982 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01036965001 9452229 9454982 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01036965001 9452229 9454982 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. IEA GO:0016615 malate dehydrogenase activity GSVIVG01036965001 9452229 9454982 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. IEA GO:0016615 malate dehydrogenase activity GSVIVG01036965001 9452229 9454982 GO:0006099 tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. IEA Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. IEA GO:0016615 malate dehydrogenase activity GSVIVG01036965001 9452229 9454982 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. IEA GO:0016615 malate dehydrogenase activity GSVIVG01036965001 9452229 9454982 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. IEA GO:0016615 malate dehydrogenase activity GSVIVG01036965001 9452229 9454982 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. IEA GO:0016615 malate dehydrogenase activity GSVIVG01036965001 9452229 9454982 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. IEA GO:0016615 malate dehydrogenase activity GSVIVG01036965001 9452229 9454982 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01036965001 9452229 9454982 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01036965001 9452229 9454982 GO:0006099 tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01036965001 9452229 9454982 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01036965001 9452229 9454982 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01036965001 9452229 9454982 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01036965001 9452229 9454982 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01036965001 9452229 9454982 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids. IEA GO:0030060 L-malate dehydrogenase activity GSVIVG01036965001 9452229 9454982 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids. IEA GO:0030060 L-malate dehydrogenase activity GSVIVG01036965001 9452229 9454982 GO:0006099 tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. IEA Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids. IEA GO:0030060 L-malate dehydrogenase activity GSVIVG01036965001 9452229 9454982 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids. IEA GO:0030060 L-malate dehydrogenase activity GSVIVG01036965001 9452229 9454982 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids. IEA GO:0030060 L-malate dehydrogenase activity GSVIVG01036965001 9452229 9454982 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids. IEA GO:0030060 L-malate dehydrogenase activity GSVIVG01036965001 9452229 9454982 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids. IEA GO:0030060 L-malate dehydrogenase activity GSVIVG01023350001 19425239 19447632 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01023350001 19425239 19447632 GO:0046470 phosphatidylcholine metabolic process The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01023350001 19425239 19447632 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate. IEA GO:0004630 phospholipase D activity GSVIVG01023350001 19425239 19447632 GO:0046470 phosphatidylcholine metabolic process The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate. IEA GO:0004630 phospholipase D activity GSVIVG01023350001 19425239 19447632 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01023350001 19425239 19447632 GO:0046470 phosphatidylcholine metabolic process The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01011452001 29768106 29770197 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01009139001 5462823 5465587 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01024860001 6395466 6396950 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01024860001 6395466 6396950 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01024860001 6395466 6396950 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01007418001 31689150 31691729 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01007418001 31689150 31691729 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01007418001 31689150 31691729 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01007418001 31689150 31691729 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01012906001 13268008 13273528 GSVIVG01036289001 3406275 3409667 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01023260001 20475139 20477084 GSVIVG01017288001 6390839 6392566 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01017288001 6390839 6392566 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01017288001 6390839 6392566 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01017288001 6390839 6392566 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01023854001 2942482 2962563 GO:0032012 regulation of ARF protein signal transduction Any process that modulates the frequency, rate or extent of ARF protein signal transduction. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Stimulates the exchange of guanyl nucleotides associated with the GTPase ARF. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. IEA GO:0005086 ARF guanyl-nucleotide exchange factor activity GSVIVG01023854001 2942482 2962563 GO:0032012 regulation of ARF protein signal transduction Any process that modulates the frequency, rate or extent of ARF protein signal transduction. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01018254001 12459463 12481188 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019374001 149997 160503 GO:0006555 methionine metabolic process The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. IEA Catalysis of the reaction: 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+. IEA GO:0004489 methylenetetrahydrofolate reductase (NADPH) activity GSVIVG01019374001 149997 160503 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+. IEA GO:0004489 methylenetetrahydrofolate reductase (NADPH) activity GSVIVG01019374001 149997 160503 GO:0006555 methionine metabolic process The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01019374001 149997 160503 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01019425001 571900 578921 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01012725001 1034269 1034868 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025214001 3233466 3236962 GO:0006559 L-phenylalanine catabolic process The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025214001 3233466 3236962 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025214001 3233466 3236962 GO:0009698 phenylpropanoid metabolic process The chemical reactions and pathways involving aromatic derivatives of trans-cinnamic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025214001 3233466 3236962 GO:0006559 L-phenylalanine catabolic process The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of ammonia (NH3) to another substance via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. IEA GO:0016211 ammonia ligase activity GSVIVG01025214001 3233466 3236962 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of ammonia (NH3) to another substance via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. IEA GO:0016211 ammonia ligase activity GSVIVG01025214001 3233466 3236962 GO:0009698 phenylpropanoid metabolic process The chemical reactions and pathways involving aromatic derivatives of trans-cinnamic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of ammonia (NH3) to another substance via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. IEA GO:0016211 ammonia ligase activity GSVIVG01025214001 3233466 3236962 GO:0006559 L-phenylalanine catabolic process The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01025214001 3233466 3236962 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01025214001 3233466 3236962 GO:0009698 phenylpropanoid metabolic process The chemical reactions and pathways involving aromatic derivatives of trans-cinnamic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01025214001 3233466 3236962 GO:0006559 L-phenylalanine catabolic process The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate. IEA GO:0016841 ammonia-lyase activity GSVIVG01025214001 3233466 3236962 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate. IEA GO:0016841 ammonia-lyase activity GSVIVG01025214001 3233466 3236962 GO:0009698 phenylpropanoid metabolic process The chemical reactions and pathways involving aromatic derivatives of trans-cinnamic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate. IEA GO:0016841 ammonia-lyase activity GSVIVG01032903001 23967474 23969295 GO:0006887 exocytosis A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell. This is the process whereby most molecules are secreted from eukaryotic cells. IEA GO:0000145 exocyst A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals. IEA GSVIVG01000725001 219760 222088 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion. IEA GO:0004806 triglyceride lipase activity GSVIVG01010283001 19016018 19020560 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01037918001 6375067 6375457 GSVIVG01011369001 29020549 29030603 GSVIVG01017988001 5297910 5298444 GSVIVG01012412001 575268 591351 GSVIVG01017688001 2661987 2665997 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01017688001 2661987 2665997 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01014483001 4318579 4320094 GSVIVG01009348001 7601609 7603009 GSVIVG01030545001 6622248 6623826 Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. IEA GO:0008171 O-methyltransferase activity GSVIVG01001282001 4962612 4965728 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001282001 4962612 4965728 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001282001 4962612 4965728 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001282001 4962612 4965728 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01001282001 4962612 4965728 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01001282001 4962612 4965728 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01001282001 4962612 4965728 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01001282001 4962612 4965728 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01001282001 4962612 4965728 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01001282001 4962612 4965728 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01001282001 4962612 4965728 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01001282001 4962612 4965728 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01001282001 4962612 4965728 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001282001 4962612 4965728 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001282001 4962612 4965728 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001282001 4962612 4965728 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01001282001 4962612 4965728 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01001282001 4962612 4965728 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01001282001 4962612 4965728 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01001282001 4962612 4965728 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01001282001 4962612 4965728 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01037814001 7603310 7604412 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Functions in the storage of nutritious substrates. IEA GO:0045735 nutrient reservoir activity GSVIVG01002017001 32302176 32303182 GSVIVG01023842001 3038681 3049098 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01023842001 3038681 3049098 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01023842001 3038681 3049098 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01023842001 3038681 3049098 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01023842001 3038681 3049098 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023842001 3038681 3049098 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023842001 3038681 3049098 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023842001 3038681 3049098 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023842001 3038681 3049098 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01023842001 3038681 3049098 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01023842001 3038681 3049098 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01023842001 3038681 3049098 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01023842001 3038681 3049098 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01023842001 3038681 3049098 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01023842001 3038681 3049098 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01023842001 3038681 3049098 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01023842001 3038681 3049098 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01023842001 3038681 3049098 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01023842001 3038681 3049098 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01023842001 3038681 3049098 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01023842001 3038681 3049098 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01023842001 3038681 3049098 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01023842001 3038681 3049098 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01023842001 3038681 3049098 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01023842001 3038681 3049098 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023842001 3038681 3049098 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023842001 3038681 3049098 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023842001 3038681 3049098 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023636001 8276744 8283599 GSVIVG01038714001 20666459 20679303 GO:0006537 glutamate biosynthetic process The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01038714001 20666459 20679303 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01038714001 20666459 20679303 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01038714001 20666459 20679303 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01038714001 20666459 20679303 GO:0006537 glutamate biosynthetic process The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01038714001 20666459 20679303 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01038714001 20666459 20679303 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01038714001 20666459 20679303 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01038714001 20666459 20679303 GO:0006537 glutamate biosynthetic process The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01038714001 20666459 20679303 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01038714001 20666459 20679303 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01038714001 20666459 20679303 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01038714001 20666459 20679303 GO:0006537 glutamate biosynthetic process The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01038714001 20666459 20679303 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01038714001 20666459 20679303 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01038714001 20666459 20679303 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01038714001 20666459 20679303 GO:0006537 glutamate biosynthetic process The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid. IEA Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0010181 FMN binding GSVIVG01038714001 20666459 20679303 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0010181 FMN binding GSVIVG01038714001 20666459 20679303 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0010181 FMN binding GSVIVG01038714001 20666459 20679303 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0010181 FMN binding GSVIVG01038714001 20666459 20679303 GO:0006537 glutamate biosynthetic process The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid. IEA Catalysis of the formation of L-glutamine and 2-oxoglutarate from L-glutamate, using NADH, NADPH or ferredoxin as hydrogen acceptors. IEA GO:0015930 glutamate synthase activity GSVIVG01038714001 20666459 20679303 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA Catalysis of the formation of L-glutamine and 2-oxoglutarate from L-glutamate, using NADH, NADPH or ferredoxin as hydrogen acceptors. IEA GO:0015930 glutamate synthase activity GSVIVG01038714001 20666459 20679303 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the formation of L-glutamine and 2-oxoglutarate from L-glutamate, using NADH, NADPH or ferredoxin as hydrogen acceptors. IEA GO:0015930 glutamate synthase activity GSVIVG01038714001 20666459 20679303 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the formation of L-glutamine and 2-oxoglutarate from L-glutamate, using NADH, NADPH or ferredoxin as hydrogen acceptors. IEA GO:0015930 glutamate synthase activity GSVIVG01038714001 20666459 20679303 GO:0006537 glutamate biosynthetic process The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01038714001 20666459 20679303 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01038714001 20666459 20679303 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01038714001 20666459 20679303 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01038714001 20666459 20679303 GO:0006537 glutamate biosynthetic process The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor GSVIVG01038714001 20666459 20679303 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor GSVIVG01038714001 20666459 20679303 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor GSVIVG01038714001 20666459 20679303 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor GSVIVG01038714001 20666459 20679303 GO:0006537 glutamate biosynthetic process The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid. IEA Catalysis of the reaction: 2 L-glutamate + NAD(P)+ = L-glutamine + 2-oxoglutarate + NAD(P)H + H+. IEA GO:0045181 glutamate synthase activity, NADH or NADPH as acceptor GSVIVG01038714001 20666459 20679303 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA Catalysis of the reaction: 2 L-glutamate + NAD(P)+ = L-glutamine + 2-oxoglutarate + NAD(P)H + H+. IEA GO:0045181 glutamate synthase activity, NADH or NADPH as acceptor GSVIVG01038714001 20666459 20679303 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2 L-glutamate + NAD(P)+ = L-glutamine + 2-oxoglutarate + NAD(P)H + H+. IEA GO:0045181 glutamate synthase activity, NADH or NADPH as acceptor GSVIVG01038714001 20666459 20679303 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2 L-glutamate + NAD(P)+ = L-glutamine + 2-oxoglutarate + NAD(P)H + H+. IEA GO:0045181 glutamate synthase activity, NADH or NADPH as acceptor GSVIVG01038714001 20666459 20679303 GO:0006537 glutamate biosynthetic process The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01038714001 20666459 20679303 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01038714001 20666459 20679303 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01038714001 20666459 20679303 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01038714001 20666459 20679303 GO:0006537 glutamate biosynthetic process The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01038714001 20666459 20679303 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01038714001 20666459 20679303 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01038714001 20666459 20679303 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01038714001 20666459 20679303 GO:0006537 glutamate biosynthetic process The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01038714001 20666459 20679303 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01038714001 20666459 20679303 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01038714001 20666459 20679303 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01032455001 27607105 27610751 GSVIVG01027406001 16991221 16996074 GSVIVG01013877001 5831336 5839256 GO:0019538 protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification. IEA Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide. IEA GO:0016671 oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor GSVIVG01013877001 5831336 5839256 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide. IEA GO:0016671 oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor GSVIVG01018878001 19034478 19035506 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA GSVIVG01018878001 19034478 19035506 GO:0009415 response to water A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water stimulus. IEA GSVIVG01014401001 3385516 3387819 GSVIVG01038525001 10992554 11002274 GO:0006820 anion transport The directed movement of anions, atoms or small molecules with a net negative charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005741 mitochondrial outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope. IEA Catalysis of the transmembrane transfer of an anion by a voltage-gated channel. An anion is a negatively charged ion. IEA GO:0008308 voltage-gated anion channel activity GSVIVG01038525001 10992554 11002274 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005741 mitochondrial outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope. IEA Catalysis of the transmembrane transfer of an anion by a voltage-gated channel. An anion is a negatively charged ion. IEA GO:0008308 voltage-gated anion channel activity GSVIVG01029364001 15412931 15415693 GSVIVG01032676001 1598629 1599930 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01032676001 1598629 1599930 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01032676001 1598629 1599930 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01032676001 1598629 1599930 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01017791001 3495045 3504373 GO:0006338 chromatin remodeling Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01017791001 3495045 3504373 GO:0006338 chromatin remodeling Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation. IEA GO:0016585 chromatin remodeling complex Any complex that mediates dynamic changes in eukaryotic chromatin. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01017791001 3495045 3504373 GO:0043044 ATP-dependent chromatin remodeling Dynamic structural changes to eukaryotic chromatin that require energy from the hydrolysis of ATP, ranging from local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation, mediated by ATP-dependent chromatin-remodelling factors. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01017791001 3495045 3504373 GO:0043044 ATP-dependent chromatin remodeling Dynamic structural changes to eukaryotic chromatin that require energy from the hydrolysis of ATP, ranging from local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation, mediated by ATP-dependent chromatin-remodelling factors. IEA GO:0016585 chromatin remodeling complex Any complex that mediates dynamic changes in eukaryotic chromatin. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01017791001 3495045 3504373 GO:0006338 chromatin remodeling Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01017791001 3495045 3504373 GO:0006338 chromatin remodeling Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation. IEA GO:0016585 chromatin remodeling complex Any complex that mediates dynamic changes in eukaryotic chromatin. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01017791001 3495045 3504373 GO:0043044 ATP-dependent chromatin remodeling Dynamic structural changes to eukaryotic chromatin that require energy from the hydrolysis of ATP, ranging from local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation, mediated by ATP-dependent chromatin-remodelling factors. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01017791001 3495045 3504373 GO:0043044 ATP-dependent chromatin remodeling Dynamic structural changes to eukaryotic chromatin that require energy from the hydrolysis of ATP, ranging from local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation, mediated by ATP-dependent chromatin-remodelling factors. IEA GO:0016585 chromatin remodeling complex Any complex that mediates dynamic changes in eukaryotic chromatin. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01017791001 3495045 3504373 GO:0006338 chromatin remodeling Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01017791001 3495045 3504373 GO:0006338 chromatin remodeling Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation. IEA GO:0016585 chromatin remodeling complex Any complex that mediates dynamic changes in eukaryotic chromatin. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01017791001 3495045 3504373 GO:0043044 ATP-dependent chromatin remodeling Dynamic structural changes to eukaryotic chromatin that require energy from the hydrolysis of ATP, ranging from local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation, mediated by ATP-dependent chromatin-remodelling factors. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01017791001 3495045 3504373 GO:0043044 ATP-dependent chromatin remodeling Dynamic structural changes to eukaryotic chromatin that require energy from the hydrolysis of ATP, ranging from local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation, mediated by ATP-dependent chromatin-remodelling factors. IEA GO:0016585 chromatin remodeling complex Any complex that mediates dynamic changes in eukaryotic chromatin. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01017791001 3495045 3504373 GO:0006338 chromatin remodeling Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017791001 3495045 3504373 GO:0006338 chromatin remodeling Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation. IEA GO:0016585 chromatin remodeling complex Any complex that mediates dynamic changes in eukaryotic chromatin. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017791001 3495045 3504373 GO:0043044 ATP-dependent chromatin remodeling Dynamic structural changes to eukaryotic chromatin that require energy from the hydrolysis of ATP, ranging from local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation, mediated by ATP-dependent chromatin-remodelling factors. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017791001 3495045 3504373 GO:0043044 ATP-dependent chromatin remodeling Dynamic structural changes to eukaryotic chromatin that require energy from the hydrolysis of ATP, ranging from local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation, mediated by ATP-dependent chromatin-remodelling factors. IEA GO:0016585 chromatin remodeling complex Any complex that mediates dynamic changes in eukaryotic chromatin. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017791001 3495045 3504373 GO:0006338 chromatin remodeling Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. IEA GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GSVIVG01017791001 3495045 3504373 GO:0006338 chromatin remodeling Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation. IEA GO:0016585 chromatin remodeling complex Any complex that mediates dynamic changes in eukaryotic chromatin. IEA Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. IEA GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GSVIVG01017791001 3495045 3504373 GO:0043044 ATP-dependent chromatin remodeling Dynamic structural changes to eukaryotic chromatin that require energy from the hydrolysis of ATP, ranging from local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation, mediated by ATP-dependent chromatin-remodelling factors. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. IEA GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GSVIVG01017791001 3495045 3504373 GO:0043044 ATP-dependent chromatin remodeling Dynamic structural changes to eukaryotic chromatin that require energy from the hydrolysis of ATP, ranging from local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation, mediated by ATP-dependent chromatin-remodelling factors. IEA GO:0016585 chromatin remodeling complex Any complex that mediates dynamic changes in eukaryotic chromatin. IEA Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. IEA GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GSVIVG01017791001 3495045 3504373 GO:0006338 chromatin remodeling Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA GO:0031491 nucleosome binding GSVIVG01017791001 3495045 3504373 GO:0006338 chromatin remodeling Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation. IEA GO:0016585 chromatin remodeling complex Any complex that mediates dynamic changes in eukaryotic chromatin. IEA Interacting selectively and non-covalently with a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA GO:0031491 nucleosome binding GSVIVG01017791001 3495045 3504373 GO:0043044 ATP-dependent chromatin remodeling Dynamic structural changes to eukaryotic chromatin that require energy from the hydrolysis of ATP, ranging from local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation, mediated by ATP-dependent chromatin-remodelling factors. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA GO:0031491 nucleosome binding GSVIVG01017791001 3495045 3504373 GO:0043044 ATP-dependent chromatin remodeling Dynamic structural changes to eukaryotic chromatin that require energy from the hydrolysis of ATP, ranging from local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation, mediated by ATP-dependent chromatin-remodelling factors. IEA GO:0016585 chromatin remodeling complex Any complex that mediates dynamic changes in eukaryotic chromatin. IEA Interacting selectively and non-covalently with a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA GO:0031491 nucleosome binding GSVIVG01028786001 18849598 18853350 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01037735001 7372209 7376801 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036258001 7924043 7935618 GO:0006189 'de novo' IMP biosynthetic process The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01036258001 7924043 7935618 GO:0006189 'de novo' IMP biosynthetic process The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate. IEA Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO2. IEA GO:0004638 phosphoribosylaminoimidazole carboxylase activity GSVIVG01036258001 7924043 7935618 GO:0006189 'de novo' IMP biosynthetic process The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017310001 6622652 6622786 GSVIVG01034674001 7488745 7491086 GO:0009116 nucleoside metabolic process The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine). IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01036932001 17430558 17432766 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01020334001 21188377 21191382 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01026176001 13431116 13431196 GSVIVG01016755001 997938 998814 GSVIVG01008708001 1357800 1364583 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01008708001 1357800 1364583 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01008708001 1357800 1364583 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008708001 1357800 1364583 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008708001 1357800 1364583 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01008708001 1357800 1364583 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01017366001 7406222 7407673 GSVIVG01008530001 1071681 1074904 GSVIVG01027982001 2960806 2962457 GSVIVG01002604001 35366715 35367435 GSVIVG01034310001 14664768 14666918 GSVIVG01013537001 2563083 2564791 GSVIVG01011146001 7222570 7227039 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01011146001 7222570 7227039 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01011146001 7222570 7227039 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01011146001 7222570 7227039 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01011146001 7222570 7227039 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01011146001 7222570 7227039 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01025217001 3142691 3144527 GO:0006730 one-carbon metabolic process The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. IEA Catalysis of the reaction: H2CO3 = CO2 + H2O. IEA GO:0004089 carbonate dehydratase activity GSVIVG01025217001 3142691 3144527 GO:0006730 one-carbon metabolic process The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01006447001 26055648 26057746 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with double-stranded RNA. IEA GO:0003725 double-stranded RNA binding GSVIVG01016775001 1234275 1238295 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01016775001 1234275 1238295 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01016775001 1234275 1238295 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015935 small ribosomal subunit The smaller of the two subunits of a ribosome. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01016775001 1234275 1238295 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01016775001 1234275 1238295 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01016775001 1234275 1238295 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015935 small ribosomal subunit The smaller of the two subunits of a ribosome. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01017129001 4430504 4440070 GO:0032312 regulation of ARF GTPase activity Any process that modulates the activity of the GTPase ARF. IEA Increases the rate of GTP hydrolysis by the GTPase ARF. IEA GO:0008060 ARF GTPase activator activity GSVIVG01017129001 4430504 4440070 GO:0032312 regulation of ARF GTPase activity Any process that modulates the activity of the GTPase ARF. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01007656001 10796674 10803874 GSVIVG01009841001 11729952 11731993 GSVIVG01034003001 15988109 15991335 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01034003001 15988109 15991335 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01034003001 15988109 15991335 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01034003001 15988109 15991335 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01034003001 15988109 15991335 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01034003001 15988109 15991335 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01019628001 2075830 2079813 GSVIVG01009728001 10827795 10830770 GSVIVG01015038001 655627 659478 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015038001 655627 659478 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01015038001 655627 659478 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01015038001 655627 659478 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01005386001 40061749 40063337 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01005386001 40061749 40063337 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01005386001 40061749 40063337 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01005386001 40061749 40063337 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01009249001 6648784 6649030 GSVIVG01034201001 14460202 14472709 GSVIVG01026360001 14964961 14966325 GSVIVG01016880001 2225152 2233977 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016880001 2225152 2233977 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016880001 2225152 2233977 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016880001 2225152 2233977 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01016880001 2225152 2233977 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01016880001 2225152 2233977 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01016880001 2225152 2233977 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01016880001 2225152 2233977 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01016880001 2225152 2233977 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01016880001 2225152 2233977 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016880001 2225152 2233977 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016880001 2225152 2233977 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016880001 2225152 2233977 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01016880001 2225152 2233977 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01016880001 2225152 2233977 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01016880001 2225152 2233977 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01016880001 2225152 2233977 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01016880001 2225152 2233977 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01016880001 2225152 2233977 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01016880001 2225152 2233977 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01016880001 2225152 2233977 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01016306001 5306153 5309819 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004185 serine-type carboxypeptidase activity GSVIVG01019039001 17481239 17483065 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01019039001 17481239 17483065 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01019039001 17481239 17483065 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01019039001 17481239 17483065 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01019039001 17481239 17483065 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01019039001 17481239 17483065 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01019039001 17481239 17483065 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019039001 17481239 17483065 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000154001 15709458 15714489 GSVIVG01013562001 20913563 20914372 GSVIVG01029732001 13830457 13845484 GO:0008654 phospholipid biosynthetic process The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester. IEA Catalysis of the reaction: phosphatidyl-L-serine = phosphatidylethanolamine + CO2. IEA GO:0004609 phosphatidylserine decarboxylase activity GSVIVG01024035001 1587484 1594374 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: 2 H2O2 = O2 + 2 H2O. IEA GO:0004096 catalase activity GSVIVG01024035001 1587484 1594374 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2 H2O2 = O2 + 2 H2O. IEA GO:0004096 catalase activity GSVIVG01024035001 1587484 1594374 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01024035001 1587484 1594374 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01024035001 1587484 1594374 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01024035001 1587484 1594374 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01022761001 16236923 16237261 GSVIVG01015667001 15251290 15254152 GSVIVG01027958001 2837049 2838821 GO:0006821 chloride transport The directed movement of chloride into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a chloride ion by a voltage-gated channel. IEA GO:0005247 voltage-gated chloride channel activity GSVIVG01027958001 2837049 2838821 GO:0006821 chloride transport The directed movement of chloride into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01011326001 8532338 8533939 Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01011326001 8532338 8533939 Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01001787001 3138580 3139487 GSVIVG01038142001 23815690 23820063 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01014276001 2259485 2272052 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01014276001 2259485 2272052 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01014276001 2259485 2272052 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01014276001 2259485 2272052 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01014276001 2259485 2272052 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01014276001 2259485 2272052 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01014276001 2259485 2272052 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01014276001 2259485 2272052 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01014276001 2259485 2272052 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01014276001 2259485 2272052 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01027646001 14685348 14688668 GSVIVG01030250001 9868366 9871899 GSVIVG01017702001 2780127 2781179 GSVIVG01027082001 18108276 18114975 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01027082001 18108276 18114975 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01027082001 18108276 18114975 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01015290001 2434577 2437702 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01015290001 2434577 2437702 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the reaction: pectin + n H2O = n methanol + pectate. IEA GO:0030599 pectinesterase activity GSVIVG01015290001 2434577 2437702 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue. IEA GO:0045330 aspartyl esterase activity GSVIVG01035006001 842262 847720 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035006001 842262 847720 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021699001 9747017 9748330 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with manganese (Mn) ions. IEA GO:0030145 manganese ion binding GSVIVG01021699001 9747017 9748330 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Functions in the storage of nutritious substrates. IEA GO:0045735 nutrient reservoir activity GSVIVG01030155001 10481015 10481251 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01030155001 10481015 10481251 GO:0006423 cysteinyl-tRNA aminoacylation The process of coupling cysteine to cysteinyl-tRNA, catalyzed by cysteinyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01030155001 10481015 10481251 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys). IEA GO:0004817 cysteine-tRNA ligase activity GSVIVG01030155001 10481015 10481251 GO:0006423 cysteinyl-tRNA aminoacylation The process of coupling cysteine to cysteinyl-tRNA, catalyzed by cysteinyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys). IEA GO:0004817 cysteine-tRNA ligase activity GSVIVG01030155001 10481015 10481251 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030155001 10481015 10481251 GO:0006423 cysteinyl-tRNA aminoacylation The process of coupling cysteine to cysteinyl-tRNA, catalyzed by cysteinyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001504001 5267660 5269238 GSVIVG01026201001 13983708 13984456 GSVIVG01015544001 4711240 4712044 GSVIVG01000544001 7246283 7247185 GSVIVG01034920001 125297 129211 GSVIVG01034242001 13369134 13400383 GSVIVG01021978001 4804552 4808495 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021978001 4804552 4808495 GO:0009073 aromatic amino acid family biosynthetic process The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021978001 4804552 4808495 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021978001 4804552 4808495 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: 3-dehydroquinate = 3-dehydroshikimate + H2O. IEA GO:0003855 3-dehydroquinate dehydratase activity GSVIVG01021978001 4804552 4808495 GO:0009073 aromatic amino acid family biosynthetic process The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: 3-dehydroquinate = 3-dehydroshikimate + H2O. IEA GO:0003855 3-dehydroquinate dehydratase activity GSVIVG01021978001 4804552 4808495 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: 3-dehydroquinate = 3-dehydroshikimate + H2O. IEA GO:0003855 3-dehydroquinate dehydratase activity GSVIVG01021978001 4804552 4808495 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: shikimate + NADP+ = 5-dehydroshikimate + NADPH + H+. IEA GO:0004764 shikimate 5-dehydrogenase activity GSVIVG01021978001 4804552 4808495 GO:0009073 aromatic amino acid family biosynthetic process The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: shikimate + NADP+ = 5-dehydroshikimate + NADPH + H+. IEA GO:0004764 shikimate 5-dehydrogenase activity GSVIVG01021978001 4804552 4808495 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: shikimate + NADP+ = 5-dehydroshikimate + NADPH + H+. IEA GO:0004764 shikimate 5-dehydrogenase activity GSVIVG01021978001 4804552 4808495 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01021978001 4804552 4808495 GO:0009073 aromatic amino acid family biosynthetic process The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01021978001 4804552 4808495 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01021978001 4804552 4808495 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01021978001 4804552 4808495 GO:0009073 aromatic amino acid family biosynthetic process The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01021978001 4804552 4808495 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01002880001 36955277 36957336 GSVIVG01038399001 11784017 11784660 GSVIVG01006001001 24355883 24356688 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with a lipid. IEA GO:0008289 lipid binding GSVIVG01006001001 24355883 24356688 GO:0006869 lipid transport The directed movement of lipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Interacting selectively and non-covalently with a lipid. IEA GO:0008289 lipid binding GSVIVG01007184001 30690555 30695719 GO:0006631 fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01007184001 30690555 30695719 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01007184001 30690555 30695719 GO:0006631 fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. IEA Catalysis of the reaction: stearoyl-[acyl-carrier protein] + reduced acceptor + O2 = oleoyl-[acyl-carrier protein] + acceptor + H2O. The enzyme requires ferredoxin. IEA GO:0045300 acyl-[acyl-carrier-protein] desaturase activity GSVIVG01007184001 30690555 30695719 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: stearoyl-[acyl-carrier protein] + reduced acceptor + O2 = oleoyl-[acyl-carrier protein] + acceptor + H2O. The enzyme requires ferredoxin. IEA GO:0045300 acyl-[acyl-carrier-protein] desaturase activity GSVIVG01007184001 30690555 30695719 GO:0006631 fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01007184001 30690555 30695719 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01021728001 10155639 10186421 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01021728001 10155639 10186421 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01021728001 10155639 10186421 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA helix. IEA GO:0003678 DNA helicase activity GSVIVG01021728001 10155639 10186421 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA helix. IEA GO:0003678 DNA helicase activity GSVIVG01021728001 10155639 10186421 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021728001 10155639 10186421 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014995001 264334 265915 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01014995001 264334 265915 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01014995001 264334 265915 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01009847001 11749843 11761172 GSVIVG01034745001 8859680 8875297 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01034745001 8859680 8875297 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01034745001 8859680 8875297 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01034745001 8859680 8875297 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034745001 8859680 8875297 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01034745001 8859680 8875297 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01034745001 8859680 8875297 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01011832001 3777955 3782630 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035357001 716417 725089 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0000159 protein phosphatase type 2A complex A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit. IEA Modulation of the activity of the enzyme protein phosphatase type 2A. IEA GO:0008601 protein phosphatase type 2A regulator activity GSVIVG01010383001 20027402 20029452 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01027270001 17318404 17321300 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01001002001 11291975 11296195 GO:0009059 macromolecule biosynthetic process The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01001002001 11291975 11296195 GO:0009059 macromolecule biosynthetic process The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. IEA Catalysis of the reaction: CoA + substrate-serine = adenosine 3',5'-bisphosphate + substrate-serine-4'-phosphopantetheine. The transfer of the 4'-phosphopantetheine (Ppant) co-factor from coenzyme A to the hydroxyl side chain of the serine residue of acyl- or peptidyl-carrier protein (ACP or PCP) to convert them from the apo to the holo form. IEA GO:0008897 holo-[acyl-carrier-protein] synthase activity GSVIVG01024287001 555307 567379 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01014673001 8458282 8459992 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01014673001 8458282 8459992 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01014673001 8458282 8459992 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01014673001 8458282 8459992 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01010397001 20152663 20154159 GSVIVG01037547001 11671991 11673247 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01017148001 4670594 4674022 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01017148001 4670594 4674022 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01017148001 4670594 4674022 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017148001 4670594 4674022 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017148001 4670594 4674022 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017148001 4670594 4674022 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017148001 4670594 4674022 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01017148001 4670594 4674022 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01024258001 273266 280142 GSVIVG01007066001 29983109 29985882 GSVIVG01010305001 19231228 19232355 GSVIVG01037960001 11678194 11681022 GSVIVG01020791001 1930939 1940636 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01031961001 5725986 5735086 GO:0007010 cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01031961001 5725986 5735086 GO:0007010 cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01031961001 5725986 5735086 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01031961001 5725986 5735086 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01031961001 5725986 5735086 GO:0007010 cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. IEA GO:0005179 hormone activity GSVIVG01031961001 5725986 5735086 GO:0007010 cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. IEA GO:0005179 hormone activity GSVIVG01031961001 5725986 5735086 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. IEA GO:0005179 hormone activity GSVIVG01031961001 5725986 5735086 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. IEA GO:0005179 hormone activity GSVIVG01031961001 5725986 5735086 GO:0007010 cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01031961001 5725986 5735086 GO:0007010 cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01031961001 5725986 5735086 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01031961001 5725986 5735086 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01031961001 5725986 5735086 GO:0007010 cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031961001 5725986 5735086 GO:0007010 cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031961001 5725986 5735086 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031961001 5725986 5735086 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01018094001 6435128 6441609 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01010855001 16882181 16885827 GSVIVG01030830001 17180807 17183309 GSVIVG01016960001 2978888 2982132 GO:0007010 cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01016960001 2978888 2982132 GO:0007010 cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. IEA GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01016960001 2978888 2982132 GO:0007010 cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01016960001 2978888 2982132 GO:0030036 actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01016960001 2978888 2982132 GO:0030036 actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. IEA GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01016960001 2978888 2982132 GO:0030036 actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01011068001 1842797 1848068 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01018886001 18962800 18964518 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01037761001 7643696 7652234 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01021720001 10002316 10010600 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021720001 10002316 10010600 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021720001 10002316 10010600 Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01018256001 12377853 12390062 GO:0006464 protein modification process The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). IEA Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein. IEA GO:0008474 palmitoyl-(protein) hydrolase activity GSVIVG01015118001 1160587 1163832 GSVIVG01025900001 27385314 27387315 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025900001 27385314 27387315 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0010181 FMN binding GSVIVG01025900001 27385314 27387315 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01019418001 505013 508954 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019418001 505013 508954 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019418001 505013 508954 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013178001 7060028 7078684 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019586001 1780007 1787739 GSVIVG01003349001 9242792 9247072 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003349001 9242792 9247072 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01003349001 9242792 9247072 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01020953001 16461183 16461720 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01031376001 19397629 19404863 GO:0005746 mitochondrial respiratory chain The protein complexes that form the mitochondrial electron transport system (the respiratory chain), associated with the inner mitochondrial membrane. The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O. IEA GO:0004129 cytochrome-c oxidase activity GSVIVG01031376001 19397629 19404863 GO:0005746 mitochondrial respiratory chain The protein complexes that form the mitochondrial electron transport system (the respiratory chain), associated with the inner mitochondrial membrane. The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01008339001 3128739 3129930 Catalysis of the reaction: ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate. IEA GO:0008440 inositol trisphosphate 3-kinase activity GSVIVG01005303001 20422764 20425267 GO:0016481 negative regulation of transcription Any cellular process that stops, prevents or reduces the frequency, rate or extent of transcription. IEA Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0010181 FMN binding GSVIVG01005303001 20422764 20425267 GO:0016481 negative regulation of transcription Any cellular process that stops, prevents or reduces the frequency, rate or extent of transcription. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024693001 7674586 7678401 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014680001 8525025 8558949 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01014680001 8525025 8558949 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01014680001 8525025 8558949 GO:0006435 threonyl-tRNA aminoacylation The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01014680001 8525025 8558949 GO:0043039 tRNA aminoacylation The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01014680001 8525025 8558949 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01014680001 8525025 8558949 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01014680001 8525025 8558949 GO:0006435 threonyl-tRNA aminoacylation The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01014680001 8525025 8558949 GO:0043039 tRNA aminoacylation The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01014680001 8525025 8558949 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr). IEA GO:0004829 threonine-tRNA ligase activity GSVIVG01014680001 8525025 8558949 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr). IEA GO:0004829 threonine-tRNA ligase activity GSVIVG01014680001 8525025 8558949 GO:0006435 threonyl-tRNA aminoacylation The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr). IEA GO:0004829 threonine-tRNA ligase activity GSVIVG01014680001 8525025 8558949 GO:0043039 tRNA aminoacylation The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr). IEA GO:0004829 threonine-tRNA ligase activity GSVIVG01014680001 8525025 8558949 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014680001 8525025 8558949 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014680001 8525025 8558949 GO:0006435 threonyl-tRNA aminoacylation The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014680001 8525025 8558949 GO:0043039 tRNA aminoacylation The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014680001 8525025 8558949 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances via a carbon-oxygen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate, to form aminoacyl-tRNA or a related compound. IEA GO:0016876 ligase activity, forming aminoacyl-tRNA and related compounds GSVIVG01014680001 8525025 8558949 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances via a carbon-oxygen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate, to form aminoacyl-tRNA or a related compound. IEA GO:0016876 ligase activity, forming aminoacyl-tRNA and related compounds GSVIVG01014680001 8525025 8558949 GO:0006435 threonyl-tRNA aminoacylation The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances via a carbon-oxygen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate, to form aminoacyl-tRNA or a related compound. IEA GO:0016876 ligase activity, forming aminoacyl-tRNA and related compounds GSVIVG01014680001 8525025 8558949 GO:0043039 tRNA aminoacylation The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances via a carbon-oxygen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate, to form aminoacyl-tRNA or a related compound. IEA GO:0016876 ligase activity, forming aminoacyl-tRNA and related compounds GSVIVG01007578001 11735839 11738219 GO:0006730 one-carbon metabolic process The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007578001 11735839 11738219 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007578001 11735839 11738219 GO:0006730 one-carbon metabolic process The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. IEA Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine. IEA GO:0004013 adenosylhomocysteinase activity GSVIVG01007578001 11735839 11738219 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine. IEA GO:0004013 adenosylhomocysteinase activity GSVIVG01007578001 11735839 11738219 GO:0006730 one-carbon metabolic process The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01007578001 11735839 11738219 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01038246001 24588859 24593551 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether. IEA GO:0008119 thiopurine S-methyltransferase activity GSVIVG01033837001 17340711 17342561 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01036511001 22862598 22865903 GSVIVG01024512001 9417872 9426432 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01024512001 9417872 9426432 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012867001 6366088 6372199 GSVIVG01025296001 2358409 2360477 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01025296001 2358409 2360477 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01025296001 2358409 2360477 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01025296001 2358409 2360477 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01025296001 2358409 2360477 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01025296001 2358409 2360477 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01025296001 2358409 2360477 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01025296001 2358409 2360477 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01025296001 2358409 2360477 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01025296001 2358409 2360477 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01025296001 2358409 2360477 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01025296001 2358409 2360477 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01025296001 2358409 2360477 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025296001 2358409 2360477 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025296001 2358409 2360477 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025296001 2358409 2360477 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025296001 2358409 2360477 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025296001 2358409 2360477 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025296001 2358409 2360477 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025296001 2358409 2360477 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025296001 2358409 2360477 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025296001 2358409 2360477 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025296001 2358409 2360477 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025296001 2358409 2360477 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028385001 6895600 6898446 GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Prevents the dissociation of GDP from the small GTPase Rho, thereby preventing GTP from binding. IEA GO:0005094 Rho GDP-dissociation inhibitor activity GSVIVG01007117001 30153816 30154387 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01023311001 19799562 19802340 GSVIVG01004864001 16183191 16195454 GSVIVG01028086001 3698477 3704634 GO:0006189 'de novo' IMP biosynthetic process The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028086001 3698477 3704634 GO:0006189 'de novo' IMP biosynthetic process The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole. IEA GO:0004641 phosphoribosylformylglycinamidine cyclo-ligase activity GSVIVG01028086001 3698477 3704634 GO:0006189 'de novo' IMP biosynthetic process The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01021644001 8638626 8639990 GSVIVG01003947001 13957179 13958702 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01003947001 13957179 13958702 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01011852001 3578146 3585426 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01011852001 3578146 3585426 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01011852001 3578146 3585426 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01011852001 3578146 3585426 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01011852001 3578146 3585426 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01011852001 3578146 3585426 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01011852001 3578146 3585426 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01011852001 3578146 3585426 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01011852001 3578146 3585426 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01011852001 3578146 3585426 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01011852001 3578146 3585426 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01011852001 3578146 3585426 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01011852001 3578146 3585426 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01011852001 3578146 3585426 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01011852001 3578146 3585426 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01011852001 3578146 3585426 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01011852001 3578146 3585426 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01011852001 3578146 3585426 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01030384001 5122428 5125164 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01030384001 5122428 5125164 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01030384001 5122428 5125164 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01030384001 5122428 5125164 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01025661001 13157074 13158029 GSVIVG01005877001 22446255 22446884 GSVIVG01023820001 3205359 3214057 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01023820001 3205359 3214057 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01008526001 1091339 1094293 GO:0006414 translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. IEA GO:0005853 eukaryotic translation elongation factor 1 complex A multisubunit nucleotide exchange complex that binds GTP and aminoacyl-tRNAs, and catalyzes their codon-dependent placement at the A-site of the ribosome. In humans, the complex is composed of four subunits, alpha, beta, delta and gamma. IEA Functions in chain elongation during polypeptide synthesis at the ribosome. IEA GO:0003746 translation elongation factor activity GSVIVG01034968001 530084 531773 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01034968001 530084 531773 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01010822001 23035016 23036755 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010822001 23035016 23036755 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038063001 17282803 17284294 GSVIVG01035388001 935962 939236 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01035388001 935962 939236 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01035388001 935962 939236 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01035388001 935962 939236 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01035388001 935962 939236 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01035388001 935962 939236 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01035388001 935962 939236 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01035388001 935962 939236 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01035388001 935962 939236 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01035388001 935962 939236 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035388001 935962 939236 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035388001 935962 939236 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035388001 935962 939236 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035388001 935962 939236 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035388001 935962 939236 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035388001 935962 939236 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035388001 935962 939236 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035388001 935962 939236 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028259001 4997710 5000938 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01028259001 4997710 5000938 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01028259001 4997710 5000938 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01028259001 4997710 5000938 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01028259001 4997710 5000938 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01028259001 4997710 5000938 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01028259001 4997710 5000938 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005267 potassium channel activity GSVIVG01028259001 4997710 5000938 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005267 potassium channel activity GSVIVG01028259001 4997710 5000938 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005267 potassium channel activity GSVIVG01028259001 4997710 5000938 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005267 potassium channel activity GSVIVG01028259001 4997710 5000938 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005267 potassium channel activity GSVIVG01028259001 4997710 5000938 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005267 potassium channel activity GSVIVG01028259001 4997710 5000938 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01028259001 4997710 5000938 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01028259001 4997710 5000938 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01028259001 4997710 5000938 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01028259001 4997710 5000938 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01028259001 4997710 5000938 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01035309001 279751 299210 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01035309001 279751 299210 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01035309001 279751 299210 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01035309001 279751 299210 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035309001 279751 299210 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038697001 20886749 20888112 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion. IEA GO:0004806 triglyceride lipase activity GSVIVG01015387001 3191384 3197996 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01015387001 3191384 3197996 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01015387001 3191384 3197996 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01015387001 3191384 3197996 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01009495001 8855047 8856210 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01009495001 8855047 8856210 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a sterol, any steroid containing a hydroxy group in the 3 position, closely related to cholestan-3-ol. IEA GO:0032934 sterol binding GSVIVG01029835001 294739 299147 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01029835001 294739 299147 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01029835001 294739 299147 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01029835001 294739 299147 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033734001 18237696 18265065 GO:0006464 protein modification process The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. IEA GO:0016881 acid-amino acid ligase activity GSVIVG01008194001 4798763 4799730 GSVIVG01034410001 16725582 16729803 GSVIVG01022096001 16540634 16544303 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01022096001 16540634 16544303 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01022096001 16540634 16544303 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01010919001 15707762 15711764 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01010919001 15707762 15711764 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01010919001 15707762 15711764 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01010919001 15707762 15711764 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01010919001 15707762 15711764 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01010919001 15707762 15711764 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01011088001 1689215 1690472 GSVIVG01035143001 1814420 1837357 GSVIVG01013787001 7582199 7588839 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01013787001 7582199 7588839 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01013787001 7582199 7588839 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01013787001 7582199 7588839 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01013787001 7582199 7588839 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013787001 7582199 7588839 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023912001 2520298 2524597 GSVIVG01024623001 8295111 8300602 GSVIVG01012821001 5751751 5754024 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01031400001 19096083 19101208 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031400001 19096083 19101208 GO:0006284 base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031400001 19096083 19101208 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. IEA GO:0004519 endonuclease activity GSVIVG01031400001 19096083 19101208 GO:0006284 base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. IEA GO:0004519 endonuclease activity GSVIVG01031400001 19096083 19101208 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051539 4 iron, 4 sulfur cluster binding GSVIVG01031400001 19096083 19101208 GO:0006284 base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. IEA Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051539 4 iron, 4 sulfur cluster binding GSVIVG01032563001 28394890 28398493 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01032563001 28394890 28398493 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01032563001 28394890 28398493 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. IEA GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GSVIVG01032563001 28394890 28398493 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species. IEA GO:0031418 L-ascorbic acid binding GSVIVG01031292001 584926 585846 GSVIVG01018598001 12517664 12518390 Stops, prevents or reduces the activity of an enzyme. IEA GO:0004857 enzyme inhibitor activity GSVIVG01018598001 12517664 12518390 Catalysis of the reaction: pectin + n H2O = n methanol + pectate. IEA GO:0030599 pectinesterase activity GSVIVG01006399001 25621460 25623974 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01006399001 25621460 25623974 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01010123001 15888300 15892532 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01010123001 15888300 15892532 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01018829001 19502782 19506001 GSVIVG01021916001 5671014 5674017 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01021916001 5671014 5674017 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01021916001 5671014 5674017 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01021916001 5671014 5674017 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01021916001 5671014 5674017 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021916001 5671014 5674017 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021916001 5671014 5674017 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01021916001 5671014 5674017 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01033158001 8627884 8628150 GSVIVG01018093001 6424263 6430178 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01018093001 6424263 6430178 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01018093001 6424263 6430178 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01018093001 6424263 6430178 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01018093001 6424263 6430178 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01018093001 6424263 6430178 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01018093001 6424263 6430178 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018093001 6424263 6430178 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010316001 19370001 19372078 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01007667001 10706429 10707300 GSVIVG01013796001 7502368 7512803 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01013796001 7502368 7512803 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01013796001 7502368 7512803 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01013796001 7502368 7512803 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034086001 15283914 15295734 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01034086001 15283914 15295734 GO:0007596 blood coagulation The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01034086001 15283914 15295734 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01034086001 15283914 15295734 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01034086001 15283914 15295734 GO:0007596 blood coagulation The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01034086001 15283914 15295734 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01015018001 490468 494415 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: UDP-glucose + D-fructose = UDP + sucrose. IEA GO:0016157 sucrose synthase activity GSVIVG01017884001 4309881 4311482 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01017884001 4309881 4311482 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01017884001 4309881 4311482 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01016709001 526730 530864 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01016709001 526730 530864 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01016709001 526730 530864 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01016709001 526730 530864 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01004908001 4730226 4736741 GSVIVG01005340001 39795469 39800381 GO:0009228 thiamin biosynthetic process The chemical reactions and pathways resulting in the formation of thiamin (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver. IEA Catalysis of the reaction: ATP + 4-methyl-5-(2-hydroxyethyl)-thiazole = ADP + 4-methyl-5-(2-phosphoethyl)-thiazole. IEA GO:0004417 hydroxyethylthiazole kinase activity GSVIVG01000051001 3092047 3097351 GO:0015671 oxygen transport The directed movement of oxygen (O2) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01000051001 3092047 3097351 GO:0015671 oxygen transport The directed movement of oxygen (O2) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with oxygen (O2). IEA GO:0019825 oxygen binding GSVIVG01000051001 3092047 3097351 GO:0015671 oxygen transport The directed movement of oxygen (O2) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01006978001 29546759 29550975 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01009959001 12838654 12840711 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01011444001 29695609 29697393 GSVIVG01036119001 20432054 20450893 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01036119001 20432054 20450893 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01027731001 7300432 7305169 GSVIVG01014004001 8820495 8824031 GSVIVG01007223001 30937610 30943117 GSVIVG01032822001 488153 492447 GSVIVG01028985001 16882273 16895215 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01023338001 19593199 19605357 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01023338001 19593199 19605357 GO:0009228 thiamin biosynthetic process The chemical reactions and pathways resulting in the formation of thiamin (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01023338001 19593199 19605357 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-4-methyl-5-(2-phosphonooxyethyl)-thiazole = diphosphate + thiamin monophosphate. IEA GO:0004789 thiamin-phosphate diphosphorylase activity GSVIVG01023338001 19593199 19605357 GO:0009228 thiamin biosynthetic process The chemical reactions and pathways resulting in the formation of thiamin (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver. IEA Catalysis of the reaction: 2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-4-methyl-5-(2-phosphonooxyethyl)-thiazole = diphosphate + thiamin monophosphate. IEA GO:0004789 thiamin-phosphate diphosphorylase activity GSVIVG01023338001 19593199 19605357 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: ATP + 4-amino-2-methyl-5-phosphomethylpyrimidine = ADP + 4-amino-2-methyl-5-diphosphomethylpyrimidine. IEA GO:0008972 phosphomethylpyrimidine kinase activity GSVIVG01023338001 19593199 19605357 GO:0009228 thiamin biosynthetic process The chemical reactions and pathways resulting in the formation of thiamin (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver. IEA Catalysis of the reaction: ATP + 4-amino-2-methyl-5-phosphomethylpyrimidine = ADP + 4-amino-2-methyl-5-diphosphomethylpyrimidine. IEA GO:0008972 phosphomethylpyrimidine kinase activity GSVIVG01003195001 7771968 7779533 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003195001 7771968 7779533 GO:0009231 riboflavin biosynthetic process The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003195001 7771968 7779533 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: ATP + riboflavin = ADP + FMN. IEA GO:0008531 riboflavin kinase activity GSVIVG01003195001 7771968 7779533 GO:0009231 riboflavin biosynthetic process The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). IEA Catalysis of the reaction: ATP + riboflavin = ADP + FMN. IEA GO:0008531 riboflavin kinase activity GSVIVG01003195001 7771968 7779533 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01003195001 7771968 7779533 GO:0009231 riboflavin biosynthetic process The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01018930001 18563504 18568390 GO:0006796 phosphate metabolic process The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01018930001 18563504 18568390 GO:0006796 phosphate metabolic process The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: diphosphate + H2O = 2 phosphate. IEA GO:0004427 inorganic diphosphatase activity GSVIVG01036750001 23010943 23012091 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GSVIVG01035846001 4818334 4838381 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01028140001 4134650 4151890 Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01037632001 6379628 6406407 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01000246001 20487152 20488674 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01005298001 20398620 20398874 GSVIVG01021126001 1688867 1693094 GO:0008219 cell death A biological process that results in permanent cessation of all vital functions of a cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01009493001 8847819 8850489 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01009493001 8847819 8850489 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01009493001 8847819 8850489 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01009493001 8847819 8850489 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01024808001 6783916 6794456 GSVIVG01037410001 14238213 14240129 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01036807001 22279115 22279775 GSVIVG01035641001 2911563 2917396 Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal. IEA GO:0004462 lactoylglutathione lyase activity GSVIVG01035641001 2911563 2917396 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01023999001 1818710 1822094 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01023999001 1818710 1822094 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01023999001 1818710 1822094 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01023999001 1818710 1822094 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01011100001 1588071 1606535 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01038244001 24575643 24580786 GSVIVG01028116001 3925887 3927766 GO:0000154 rRNA modification The covalent alteration of one or more nucleotides within an rRNA molecule to produce an rRNA molecule with a sequence that differs from that coded genetically. IEA Catalysis of the dimethylation two adjacent A residues in the loop closing the 3'-terminal stem of the 18S rRNA, using S-adenosyl-L-methionine as a methyl donor. IEA GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity GSVIVG01028116001 3925887 3927766 GO:0006364 rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. IEA Catalysis of the dimethylation two adjacent A residues in the loop closing the 3'-terminal stem of the 18S rRNA, using S-adenosyl-L-methionine as a methyl donor. IEA GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity GSVIVG01028116001 3925887 3927766 GO:0000154 rRNA modification The covalent alteration of one or more nucleotides within an rRNA molecule to produce an rRNA molecule with a sequence that differs from that coded genetically. IEA Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule. IEA GO:0008649 rRNA methyltransferase activity GSVIVG01028116001 3925887 3927766 GO:0006364 rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. IEA Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule. IEA GO:0008649 rRNA methyltransferase activity GSVIVG01028116001 3925887 3927766 GO:0000154 rRNA modification The covalent alteration of one or more nucleotides within an rRNA molecule to produce an rRNA molecule with a sequence that differs from that coded genetically. IEA Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to an adenine residue in an rRNA molecule. IEA GO:0016433 rRNA (adenine) methyltransferase activity GSVIVG01028116001 3925887 3927766 GO:0006364 rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. IEA Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to an adenine residue in an rRNA molecule. IEA GO:0016433 rRNA (adenine) methyltransferase activity GSVIVG01022130001 16814191 16820706 GSVIVG01026711001 5302816 5309994 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01026711001 5302816 5309994 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01026711001 5302816 5309994 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01026711001 5302816 5309994 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017568001 10684252 10689264 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01017568001 10684252 10689264 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01017568001 10684252 10689264 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01017568001 10684252 10689264 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01017568001 10684252 10689264 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010205001 17376950 17379343 GO:0009416 response to light stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01010205001 17376950 17379343 GO:0009416 response to light stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01022250001 17829856 17849453 GSVIVG01026731001 5745382 5767542 GSVIVG01009670001 10334342 10341089 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009670001 10334342 10341089 Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity. IEA GO:0004721 phosphoprotein phosphatase activity GSVIVG01016187001 6894900 6899920 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004185 serine-type carboxypeptidase activity GSVIVG01031966001 5783040 5789875 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01031966001 5783040 5789875 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01031966001 5783040 5789875 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031966001 5783040 5789875 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016651 oxidoreductase activity, acting on NADH or NADPH GSVIVG01031966001 5783040 5789875 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01031966001 5783040 5789875 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051539 4 iron, 4 sulfur cluster binding GSVIVG01016544001 2950889 2951107 GSVIVG01011280001 10486406 10493525 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01011636001 5694701 5696103 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01034081001 15323218 15334223 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01034081001 15323218 15334223 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01034081001 15323218 15334223 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme. IEA GO:0004867 serine-type endopeptidase inhibitor activity GSVIVG01034081001 15323218 15334223 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021867001 6261382 6267145 GO:0006535 cysteine biosynthetic process from serine The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021867001 6261382 6267145 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021867001 6261382 6267145 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021867001 6261382 6267145 GO:0019344 cysteine biosynthetic process The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021867001 6261382 6267145 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021867001 6261382 6267145 GO:0006535 cysteine biosynthetic process from serine The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine. IEA Catalysis of the reaction: O3-acetyl-L-serine + H2S = L-cysteine + acetate. IEA GO:0004124 cysteine synthase activity GSVIVG01021867001 6261382 6267145 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: O3-acetyl-L-serine + H2S = L-cysteine + acetate. IEA GO:0004124 cysteine synthase activity GSVIVG01021867001 6261382 6267145 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the reaction: O3-acetyl-L-serine + H2S = L-cysteine + acetate. IEA GO:0004124 cysteine synthase activity GSVIVG01021867001 6261382 6267145 GO:0019344 cysteine biosynthetic process The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid. IEA Catalysis of the reaction: O3-acetyl-L-serine + H2S = L-cysteine + acetate. IEA GO:0004124 cysteine synthase activity GSVIVG01021867001 6261382 6267145 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: O3-acetyl-L-serine + H2S = L-cysteine + acetate. IEA GO:0004124 cysteine synthase activity GSVIVG01021867001 6261382 6267145 GO:0006535 cysteine biosynthetic process from serine The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021867001 6261382 6267145 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021867001 6261382 6267145 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021867001 6261382 6267145 GO:0019344 cysteine biosynthetic process The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021867001 6261382 6267145 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021867001 6261382 6267145 GO:0006535 cysteine biosynthetic process from serine The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01021867001 6261382 6267145 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01021867001 6261382 6267145 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01021867001 6261382 6267145 GO:0019344 cysteine biosynthetic process The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01021867001 6261382 6267145 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01021867001 6261382 6267145 GO:0006535 cysteine biosynthetic process from serine The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01021867001 6261382 6267145 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01021867001 6261382 6267145 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01021867001 6261382 6267145 GO:0019344 cysteine biosynthetic process The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01021867001 6261382 6267145 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01014050001 10063604 10066306 GSVIVG01020539001 4676278 4683738 GSVIVG01032382001 26840636 26847551 GSVIVG01025823001 11489999 11491245 GSVIVG01030988001 20360562 20365553 GSVIVG01020268001 22070987 22071806 GSVIVG01012528001 669675 669928 GSVIVG01021183001 2345176 2351311 GSVIVG01004857001 130080 133025 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01004857001 130080 133025 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01003560001 14654552 14654837 GSVIVG01003839001 20563525 20579978 GO:0006614 SRP-dependent cotranslational protein targeting to membrane The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01003839001 20563525 20579978 GO:0007021 tubulin complex assembly The aggregation and bonding together of alpha- and beta-tubulin to form a tubulin heterodimer. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01003839001 20563525 20579978 GO:0006614 SRP-dependent cotranslational protein targeting to membrane The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01003839001 20563525 20579978 GO:0007021 tubulin complex assembly The aggregation and bonding together of alpha- and beta-tubulin to form a tubulin heterodimer. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01003839001 20563525 20579978 GO:0006614 SRP-dependent cotranslational protein targeting to membrane The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01003839001 20563525 20579978 GO:0007021 tubulin complex assembly The aggregation and bonding together of alpha- and beta-tubulin to form a tubulin heterodimer. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01017830001 3846131 3847498 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01017830001 3846131 3847498 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01017830001 3846131 3847498 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01017830001 3846131 3847498 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01031395001 19162672 19163151 GSVIVG01029794001 14752087 14778914 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029794001 14752087 14778914 Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity. IEA GO:0004721 phosphoprotein phosphatase activity GSVIVG01035520001 1976949 1978455 GSVIVG01031402001 19055656 19056778 GSVIVG01005670001 21073186 21091606 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GSVIVG01024804001 6813839 6831126 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: 1,4-alpha-D-glucosyl(n) + phosphate = 1,4-alpha-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate. The name should be qualified in each instance by adding the name of the natural substrate, e.g. maltodextrin phosphorylase, starch phosphorylase, glycogen phosphorylase. IEA GO:0004645 phosphorylase activity GSVIVG01024804001 6813839 6831126 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01013297001 456629 457858 GSVIVG01030670001 13271881 13272256 GSVIVG01009664001 10308210 10309560 GSVIVG01033545001 19856122 19861354 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033545001 19856122 19861354 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01033545001 19856122 19861354 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01032602001 28763430 28765178 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01032432001 27329416 27346395 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026601001 21163786 21172634 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01030515001 6403232 6404450 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01030515001 6403232 6404450 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01019526001 1342881 1348591 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01019933001 4578043 4585763 GSVIVG01028849001 18105331 18107713 GSVIVG01022489001 3761292 3764659 The action of a molecule that contributes to the structural integrity of a cell wall. IEA GO:0005199 structural constituent of cell wall GSVIVG01015168001 1510886 1516744 GO:0006090 pyruvate metabolic process The chemical reactions and pathways involving pyruvate, 2-oxopropanoate. IEA GO:0045254 pyruvate dehydrogenase complex Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). IEA Catalysis of the reaction: acetyl-CoA + dihydrolipoamide = CoA + S-acetyldihydrolipoamide. IEA GO:0004742 dihydrolipoyllysine-residue acetyltransferase activity GSVIVG01015168001 1510886 1516744 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0045254 pyruvate dehydrogenase complex Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). IEA Catalysis of the reaction: acetyl-CoA + dihydrolipoamide = CoA + S-acetyldihydrolipoamide. IEA GO:0004742 dihydrolipoyllysine-residue acetyltransferase activity GSVIVG01015168001 1510886 1516744 GO:0006090 pyruvate metabolic process The chemical reactions and pathways involving pyruvate, 2-oxopropanoate. IEA GO:0045254 pyruvate dehydrogenase complex Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01015168001 1510886 1516744 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0045254 pyruvate dehydrogenase complex Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01015168001 1510886 1516744 GO:0006090 pyruvate metabolic process The chemical reactions and pathways involving pyruvate, 2-oxopropanoate. IEA GO:0045254 pyruvate dehydrogenase complex Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01015168001 1510886 1516744 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0045254 pyruvate dehydrogenase complex Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01035759001 4058298 4065804 GSVIVG01015820001 17885347 17885890 GSVIVG01027573001 15448121 15451800 GSVIVG01004132001 15163386 15165090 GSVIVG01031916001 5353550 5355228 GSVIVG01034987001 690221 694301 GSVIVG01021367001 4543763 4571056 GSVIVG01010326001 19526696 19532390 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01010326001 19526696 19532390 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01010326001 19526696 19532390 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01010326001 19526696 19532390 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01010326001 19526696 19532390 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01010326001 19526696 19532390 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01010326001 19526696 19532390 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005254 chloride channel activity GSVIVG01010326001 19526696 19532390 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005254 chloride channel activity GSVIVG01010326001 19526696 19532390 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005254 chloride channel activity GSVIVG01010326001 19526696 19532390 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005254 chloride channel activity GSVIVG01010326001 19526696 19532390 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005254 chloride channel activity GSVIVG01010326001 19526696 19532390 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005254 chloride channel activity GSVIVG01010326001 19526696 19532390 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010326001 19526696 19532390 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010326001 19526696 19532390 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010326001 19526696 19532390 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010326001 19526696 19532390 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010326001 19526696 19532390 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010326001 19526696 19532390 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01010326001 19526696 19532390 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01010326001 19526696 19532390 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01010326001 19526696 19532390 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01010326001 19526696 19532390 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01010326001 19526696 19532390 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01010326001 19526696 19532390 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01010326001 19526696 19532390 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01010326001 19526696 19532390 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01010326001 19526696 19532390 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01010326001 19526696 19532390 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01010326001 19526696 19532390 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01010326001 19526696 19532390 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01010326001 19526696 19532390 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01010326001 19526696 19532390 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01010326001 19526696 19532390 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01010326001 19526696 19532390 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01010326001 19526696 19532390 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01032138001 22272771 22279676 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01032138001 22272771 22279676 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01032138001 22272771 22279676 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. IEA GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity GSVIVG01032138001 22272771 22279676 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. IEA GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity GSVIVG01032138001 22272771 22279676 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032138001 22272771 22279676 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010063001 14497779 14497910 GSVIVG01028613001 10774970 10775246 GSVIVG01036378001 4401684 4413210 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01026019001 25815319 25820332 GSVIVG01023378001 19191919 19193992 GSVIVG01008260001 3898802 3949355 GSVIVG01008466001 1702671 1706116 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01019530001 1379253 1382859 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01019530001 1379253 1382859 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008647001 144884 156662 GSVIVG01011646001 5616008 5621081 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. IEA GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor GSVIVG01011646001 5616008 5621081 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01026951001 19103591 19106611 GO:0006535 cysteine biosynthetic process from serine The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026951001 19103591 19106611 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026951001 19103591 19106611 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026951001 19103591 19106611 GO:0019344 cysteine biosynthetic process The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026951001 19103591 19106611 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026951001 19103591 19106611 GO:0006535 cysteine biosynthetic process from serine The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine. IEA Catalysis of the reaction: O3-acetyl-L-serine + H2S = L-cysteine + acetate. IEA GO:0004124 cysteine synthase activity GSVIVG01026951001 19103591 19106611 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: O3-acetyl-L-serine + H2S = L-cysteine + acetate. IEA GO:0004124 cysteine synthase activity GSVIVG01026951001 19103591 19106611 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the reaction: O3-acetyl-L-serine + H2S = L-cysteine + acetate. IEA GO:0004124 cysteine synthase activity GSVIVG01026951001 19103591 19106611 GO:0019344 cysteine biosynthetic process The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid. IEA Catalysis of the reaction: O3-acetyl-L-serine + H2S = L-cysteine + acetate. IEA GO:0004124 cysteine synthase activity GSVIVG01026951001 19103591 19106611 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: O3-acetyl-L-serine + H2S = L-cysteine + acetate. IEA GO:0004124 cysteine synthase activity GSVIVG01026951001 19103591 19106611 GO:0006535 cysteine biosynthetic process from serine The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01026951001 19103591 19106611 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01026951001 19103591 19106611 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01026951001 19103591 19106611 GO:0019344 cysteine biosynthetic process The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01026951001 19103591 19106611 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01026951001 19103591 19106611 GO:0006535 cysteine biosynthetic process from serine The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01026951001 19103591 19106611 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01026951001 19103591 19106611 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01026951001 19103591 19106611 GO:0019344 cysteine biosynthetic process The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01026951001 19103591 19106611 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01026951001 19103591 19106611 GO:0006535 cysteine biosynthetic process from serine The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01026951001 19103591 19106611 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01026951001 19103591 19106611 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01026951001 19103591 19106611 GO:0019344 cysteine biosynthetic process The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01026951001 19103591 19106611 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01035672001 3185998 3191025 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01004328001 38108964 38111582 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01015437001 3684637 3688936 GSVIVG01022666001 14338052 14338661 GSVIVG01026978001 18873341 18874841 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01026978001 18873341 18874841 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01024240001 134706 136238 GSVIVG01032279001 14436559 14446770 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA GSVIVG01011797001 4078661 4083717 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01011797001 4078661 4083717 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01011797001 4078661 4083717 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01011797001 4078661 4083717 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01011797001 4078661 4083717 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01011797001 4078661 4083717 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01011797001 4078661 4083717 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01011797001 4078661 4083717 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01011797001 4078661 4083717 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01011797001 4078661 4083717 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01011797001 4078661 4083717 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01011797001 4078661 4083717 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01011797001 4078661 4083717 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01011797001 4078661 4083717 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01011797001 4078661 4083717 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01011797001 4078661 4083717 GO:0042777 plasma membrane ATP synthesis coupled proton transport The transport of protons across the plasma membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01011797001 4078661 4083717 GO:0042777 plasma membrane ATP synthesis coupled proton transport The transport of protons across the plasma membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01011797001 4078661 4083717 GO:0042777 plasma membrane ATP synthesis coupled proton transport The transport of protons across the plasma membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01011797001 4078661 4083717 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01011797001 4078661 4083717 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01011797001 4078661 4083717 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01011797001 4078661 4083717 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011797001 4078661 4083717 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011797001 4078661 4083717 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011797001 4078661 4083717 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011797001 4078661 4083717 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011797001 4078661 4083717 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011797001 4078661 4083717 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011797001 4078661 4083717 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011797001 4078661 4083717 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011797001 4078661 4083717 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011797001 4078661 4083717 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011797001 4078661 4083717 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011797001 4078661 4083717 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011797001 4078661 4083717 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011797001 4078661 4083717 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011797001 4078661 4083717 GO:0042777 plasma membrane ATP synthesis coupled proton transport The transport of protons across the plasma membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011797001 4078661 4083717 GO:0042777 plasma membrane ATP synthesis coupled proton transport The transport of protons across the plasma membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011797001 4078661 4083717 GO:0042777 plasma membrane ATP synthesis coupled proton transport The transport of protons across the plasma membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011797001 4078661 4083717 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011797001 4078661 4083717 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011797001 4078661 4083717 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011797001 4078661 4083717 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out); by a phosphorylative mechanism. IEA GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism GSVIVG01011797001 4078661 4083717 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out); by a phosphorylative mechanism. IEA GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism GSVIVG01011797001 4078661 4083717 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out); by a phosphorylative mechanism. IEA GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism GSVIVG01011797001 4078661 4083717 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out); by a phosphorylative mechanism. IEA GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism GSVIVG01011797001 4078661 4083717 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out); by a phosphorylative mechanism. IEA GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism GSVIVG01011797001 4078661 4083717 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out); by a phosphorylative mechanism. IEA GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism GSVIVG01011797001 4078661 4083717 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out); by a phosphorylative mechanism. IEA GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism GSVIVG01011797001 4078661 4083717 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out); by a phosphorylative mechanism. IEA GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism GSVIVG01011797001 4078661 4083717 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out); by a phosphorylative mechanism. IEA GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism GSVIVG01011797001 4078661 4083717 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out); by a phosphorylative mechanism. IEA GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism GSVIVG01011797001 4078661 4083717 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out); by a phosphorylative mechanism. IEA GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism GSVIVG01011797001 4078661 4083717 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out); by a phosphorylative mechanism. IEA GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism GSVIVG01011797001 4078661 4083717 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out); by a phosphorylative mechanism. IEA GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism GSVIVG01011797001 4078661 4083717 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out); by a phosphorylative mechanism. IEA GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism GSVIVG01011797001 4078661 4083717 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out); by a phosphorylative mechanism. IEA GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism GSVIVG01011797001 4078661 4083717 GO:0042777 plasma membrane ATP synthesis coupled proton transport The transport of protons across the plasma membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out); by a phosphorylative mechanism. IEA GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism GSVIVG01011797001 4078661 4083717 GO:0042777 plasma membrane ATP synthesis coupled proton transport The transport of protons across the plasma membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out); by a phosphorylative mechanism. IEA GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism GSVIVG01011797001 4078661 4083717 GO:0042777 plasma membrane ATP synthesis coupled proton transport The transport of protons across the plasma membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out); by a phosphorylative mechanism. IEA GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism GSVIVG01011797001 4078661 4083717 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out); by a phosphorylative mechanism. IEA GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism GSVIVG01011797001 4078661 4083717 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out); by a phosphorylative mechanism. IEA GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism GSVIVG01011797001 4078661 4083717 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out); by a phosphorylative mechanism. IEA GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism GSVIVG01011797001 4078661 4083717 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01011797001 4078661 4083717 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01011797001 4078661 4083717 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01011797001 4078661 4083717 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01011797001 4078661 4083717 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01011797001 4078661 4083717 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01011797001 4078661 4083717 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01011797001 4078661 4083717 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01011797001 4078661 4083717 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01011797001 4078661 4083717 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01011797001 4078661 4083717 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01011797001 4078661 4083717 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01011797001 4078661 4083717 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01011797001 4078661 4083717 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01011797001 4078661 4083717 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01011797001 4078661 4083717 GO:0042777 plasma membrane ATP synthesis coupled proton transport The transport of protons across the plasma membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01011797001 4078661 4083717 GO:0042777 plasma membrane ATP synthesis coupled proton transport The transport of protons across the plasma membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01011797001 4078661 4083717 GO:0042777 plasma membrane ATP synthesis coupled proton transport The transport of protons across the plasma membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01011797001 4078661 4083717 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01011797001 4078661 4083717 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01011797001 4078661 4083717 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01011797001 4078661 4083717 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01011797001 4078661 4083717 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01011797001 4078661 4083717 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01011797001 4078661 4083717 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01011797001 4078661 4083717 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01011797001 4078661 4083717 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01011797001 4078661 4083717 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01011797001 4078661 4083717 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01011797001 4078661 4083717 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01011797001 4078661 4083717 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01011797001 4078661 4083717 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01011797001 4078661 4083717 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01011797001 4078661 4083717 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01011797001 4078661 4083717 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01011797001 4078661 4083717 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01011797001 4078661 4083717 GO:0042777 plasma membrane ATP synthesis coupled proton transport The transport of protons across the plasma membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01011797001 4078661 4083717 GO:0042777 plasma membrane ATP synthesis coupled proton transport The transport of protons across the plasma membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01011797001 4078661 4083717 GO:0042777 plasma membrane ATP synthesis coupled proton transport The transport of protons across the plasma membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01011797001 4078661 4083717 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01011797001 4078661 4083717 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01011797001 4078661 4083717 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01011797001 4078661 4083717 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01011797001 4078661 4083717 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01011797001 4078661 4083717 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01011797001 4078661 4083717 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01011797001 4078661 4083717 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01011797001 4078661 4083717 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01011797001 4078661 4083717 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01011797001 4078661 4083717 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01011797001 4078661 4083717 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01011797001 4078661 4083717 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01011797001 4078661 4083717 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01011797001 4078661 4083717 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01011797001 4078661 4083717 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01011797001 4078661 4083717 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01011797001 4078661 4083717 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01011797001 4078661 4083717 GO:0042777 plasma membrane ATP synthesis coupled proton transport The transport of protons across the plasma membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01011797001 4078661 4083717 GO:0042777 plasma membrane ATP synthesis coupled proton transport The transport of protons across the plasma membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01011797001 4078661 4083717 GO:0042777 plasma membrane ATP synthesis coupled proton transport The transport of protons across the plasma membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01011797001 4078661 4083717 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01011797001 4078661 4083717 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01011797001 4078661 4083717 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01011797001 4078661 4083717 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01011797001 4078661 4083717 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01011797001 4078661 4083717 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01011797001 4078661 4083717 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01011797001 4078661 4083717 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01011797001 4078661 4083717 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01011797001 4078661 4083717 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01011797001 4078661 4083717 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01011797001 4078661 4083717 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01011797001 4078661 4083717 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01011797001 4078661 4083717 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01011797001 4078661 4083717 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01011797001 4078661 4083717 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01011797001 4078661 4083717 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01011797001 4078661 4083717 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01011797001 4078661 4083717 GO:0042777 plasma membrane ATP synthesis coupled proton transport The transport of protons across the plasma membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01011797001 4078661 4083717 GO:0042777 plasma membrane ATP synthesis coupled proton transport The transport of protons across the plasma membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01011797001 4078661 4083717 GO:0042777 plasma membrane ATP synthesis coupled proton transport The transport of protons across the plasma membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01011797001 4078661 4083717 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01011797001 4078661 4083717 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01011797001 4078661 4083717 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01021609001 7992269 7997776 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01021609001 7992269 7997776 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01021609001 7992269 7997776 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01029217001 18435079 18445231 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029217001 18435079 18445231 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01018209001 13197978 13218235 GSVIVG01000975001 11016547 11016831 GSVIVG01000538001 7278723 7279552 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000538001 7278723 7279552 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01020860001 910386 915231 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01020860001 910386 915231 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01020860001 910386 915231 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01020860001 910386 915231 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015561001 4931061 4933737 Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01015561001 4931061 4933737 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01002711001 35956615 35956809 GSVIVG01034028001 15722222 15736139 GSVIVG01035887001 5305246 5339742 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01030282001 9520830 9524603 GSVIVG01021299001 3684608 3685842 GSVIVG01017668001 2489472 2490792 GSVIVG01015515001 4365744 4380490 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01015515001 4365744 4380490 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01015515001 4365744 4380490 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01015515001 4365744 4380490 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015515001 4365744 4380490 Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01014453001 3904135 3904689 GSVIVG01000262001 20683940 20690017 GO:0006306 DNA methylation The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01000262001 20683940 20690017 GO:0006306 DNA methylation The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing cytosine = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine. IEA GO:0003886 DNA (cytosine-5-)-methyltransferase activity GSVIVG01000262001 20683940 20690017 GO:0006306 DNA methylation The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000262001 20683940 20690017 GO:0006306 DNA methylation The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01000262001 20683940 20690017 GO:0006306 DNA methylation The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01011434001 29628416 29629751 GSVIVG01026420001 23760778 23765255 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01026420001 23760778 23765255 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01026420001 23760778 23765255 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01026420001 23760778 23765255 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01026420001 23760778 23765255 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0008236 serine-type peptidase activity GSVIVG01026420001 23760778 23765255 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0008236 serine-type peptidase activity GSVIVG01026420001 23760778 23765255 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01026420001 23760778 23765255 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01026420001 23760778 23765255 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01026420001 23760778 23765255 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01038516001 10861543 10868308 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01038516001 10861543 10868308 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01012879001 6468000 6472819 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012879001 6468000 6472819 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. IEA GO:0004722 protein serine/threonine phosphatase activity GSVIVG01026275001 15271383 15274580 GSVIVG01016640001 2241903 2246167 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01016640001 2241903 2246167 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01010454001 20746045 20750153 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01001982001 6031510 6033388 Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01001982001 6031510 6033388 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01010369001 19882932 19887719 GSVIVG01006734001 27845428 27846169 GSVIVG01024477001 3100029 3100436 GSVIVG01002747001 36304598 36306566 GSVIVG01029766001 14416563 14419921 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01029766001 14416563 14419921 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01029766001 14416563 14419921 GO:0008272 sulfate transport The directed movement of sulfate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01029766001 14416563 14419921 GO:0008272 sulfate transport The directed movement of sulfate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01029766001 14416563 14419921 GO:0051260 protein homooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01029766001 14416563 14419921 GO:0051260 protein homooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01029766001 14416563 14419921 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01029766001 14416563 14419921 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01029766001 14416563 14419921 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01029766001 14416563 14419921 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01029766001 14416563 14419921 GO:0008272 sulfate transport The directed movement of sulfate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01029766001 14416563 14419921 GO:0008272 sulfate transport The directed movement of sulfate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01029766001 14416563 14419921 GO:0051260 protein homooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01029766001 14416563 14419921 GO:0051260 protein homooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01029766001 14416563 14419921 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01029766001 14416563 14419921 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01019488001 1050410 1052639 GSVIVG01037287001 16433083 16481317 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of a cytoskeletal structure. IEA GO:0005200 structural constituent of cytoskeleton GSVIVG01031110001 2077966 2078580 GSVIVG01014571001 5304037 5310414 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014571001 5304037 5310414 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014571001 5304037 5310414 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014571001 5304037 5310414 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010671001 15296723 15297202 GSVIVG01035111001 1549526 1551949 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015227001 1970479 1973376 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids. IEA GO:0004518 nuclease activity GSVIVG01009701001 10597337 10602540 GSVIVG01003922001 13777373 13779954 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01030422001 5446845 5447940 GSVIVG01024060001 1441276 1442006 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate. IEA GO:0004629 phospholipase C activity GSVIVG01024060001 1441276 1442006 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. IEA GO:0008081 phosphoric diester hydrolase activity GSVIVG01001639001 21645985 21653689 GSVIVG01002531001 35224639 35226673 GSVIVG01004282001 37944910 37945712 GSVIVG01035680001 3276690 3281635 GSVIVG01020000001 11789588 11793565 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01020000001 11789588 11793565 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01020000001 11789588 11793565 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01020000001 11789588 11793565 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01007655001 10807098 10814954 GSVIVG01037899001 6538902 6539957 GSVIVG01031753001 4060722 4066802 GSVIVG01038667001 21105156 21105374 GSVIVG01023896001 2609547 2612364 GSVIVG01025462001 667647 671356 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01025462001 667647 671356 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01025462001 667647 671356 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01025462001 667647 671356 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01025462001 667647 671356 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01025462001 667647 671356 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01025462001 667647 671356 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01025462001 667647 671356 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01025462001 667647 671356 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01025462001 667647 671356 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01025462001 667647 671356 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01025462001 667647 671356 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01025462001 667647 671356 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01025462001 667647 671356 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01025462001 667647 671356 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01025462001 667647 671356 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01025462001 667647 671356 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01025462001 667647 671356 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01025462001 667647 671356 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01025462001 667647 671356 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01025462001 667647 671356 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01025462001 667647 671356 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01025462001 667647 671356 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01025462001 667647 671356 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01025462001 667647 671356 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01025462001 667647 671356 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01025462001 667647 671356 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01018839001 19395438 19397804 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01018839001 19395438 19397804 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01018839001 19395438 19397804 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01018839001 19395438 19397804 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01018839001 19395438 19397804 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01018839001 19395438 19397804 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01018839001 19395438 19397804 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01018839001 19395438 19397804 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01018839001 19395438 19397804 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01034989001 710744 719210 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01034989001 710744 719210 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01034989001 710744 719210 GO:0007600 sensory perception The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01034989001 710744 719210 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01034989001 710744 719210 GO:0018298 protein-chromophore linkage The covalent or noncovalent linking of a chromophore to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01034989001 710744 719210 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01034989001 710744 719210 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01034989001 710744 719210 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01034989001 710744 719210 GO:0007600 sensory perception The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01034989001 710744 719210 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01034989001 710744 719210 GO:0018298 protein-chromophore linkage The covalent or noncovalent linking of a chromophore to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01034989001 710744 719210 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01034989001 710744 719210 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01034989001 710744 719210 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01034989001 710744 719210 GO:0007600 sensory perception The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01034989001 710744 719210 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01034989001 710744 719210 GO:0018298 protein-chromophore linkage The covalent or noncovalent linking of a chromophore to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01034989001 710744 719210 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01034989001 710744 719210 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01034989001 710744 719210 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01034989001 710744 719210 GO:0007600 sensory perception The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01034989001 710744 719210 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01034989001 710744 719210 GO:0018298 protein-chromophore linkage The covalent or noncovalent linking of a chromophore to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01034989001 710744 719210 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01034989001 710744 719210 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034989001 710744 719210 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034989001 710744 719210 GO:0007600 sensory perception The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034989001 710744 719210 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034989001 710744 719210 GO:0018298 protein-chromophore linkage The covalent or noncovalent linking of a chromophore to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034989001 710744 719210 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034989001 710744 719210 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A G-protein coupled receptor that responds to incidental electromagnetic radiation, particularly visible light. IEA GO:0008020 G-protein coupled photoreceptor activity GSVIVG01034989001 710744 719210 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A G-protein coupled receptor that responds to incidental electromagnetic radiation, particularly visible light. IEA GO:0008020 G-protein coupled photoreceptor activity GSVIVG01034989001 710744 719210 GO:0007600 sensory perception The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A G-protein coupled receptor that responds to incidental electromagnetic radiation, particularly visible light. IEA GO:0008020 G-protein coupled photoreceptor activity GSVIVG01034989001 710744 719210 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A G-protein coupled receptor that responds to incidental electromagnetic radiation, particularly visible light. IEA GO:0008020 G-protein coupled photoreceptor activity GSVIVG01034989001 710744 719210 GO:0018298 protein-chromophore linkage The covalent or noncovalent linking of a chromophore to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A G-protein coupled receptor that responds to incidental electromagnetic radiation, particularly visible light. IEA GO:0008020 G-protein coupled photoreceptor activity GSVIVG01034989001 710744 719210 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A G-protein coupled receptor that responds to incidental electromagnetic radiation, particularly visible light. IEA GO:0008020 G-protein coupled photoreceptor activity GSVIVG01021264001 3168968 3190268 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0009360 DNA polymerase III complex A DNA polymerase complex that contains two complexes of the catalytic alpha, beta, delta and epsilon polymerase/exonuclease subunits, plus the DnaX complex, a heptamer that includes the tau and gamma products of the dnaX gene and confers structural asymmetry that allows the polymerase to replicate both leading and lagging strands. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01021264001 3168968 3190268 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0009360 DNA polymerase III complex A DNA polymerase complex that contains two complexes of the catalytic alpha, beta, delta and epsilon polymerase/exonuclease subunits, plus the DnaX complex, a heptamer that includes the tau and gamma products of the dnaX gene and confers structural asymmetry that allows the polymerase to replicate both leading and lagging strands. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01021264001 3168968 3190268 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0009360 DNA polymerase III complex A DNA polymerase complex that contains two complexes of the catalytic alpha, beta, delta and epsilon polymerase/exonuclease subunits, plus the DnaX complex, a heptamer that includes the tau and gamma products of the dnaX gene and confers structural asymmetry that allows the polymerase to replicate both leading and lagging strands. IEA Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and primer. IEA GO:0003887 DNA-directed DNA polymerase activity GSVIVG01021264001 3168968 3190268 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0009360 DNA polymerase III complex A DNA polymerase complex that contains two complexes of the catalytic alpha, beta, delta and epsilon polymerase/exonuclease subunits, plus the DnaX complex, a heptamer that includes the tau and gamma products of the dnaX gene and confers structural asymmetry that allows the polymerase to replicate both leading and lagging strands. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021264001 3168968 3190268 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0009360 DNA polymerase III complex A DNA polymerase complex that contains two complexes of the catalytic alpha, beta, delta and epsilon polymerase/exonuclease subunits, plus the DnaX complex, a heptamer that includes the tau and gamma products of the dnaX gene and confers structural asymmetry that allows the polymerase to replicate both leading and lagging strands. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01009242001 6561402 6573040 GSVIVG01035587001 2534504 2547915 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01021197001 2489087 2491437 GSVIVG01009412001 8151295 8153837 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01009412001 8151295 8153837 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01009412001 8151295 8153837 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01009412001 8151295 8153837 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01009412001 8151295 8153837 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01009412001 8151295 8153837 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01009412001 8151295 8153837 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009412001 8151295 8153837 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009412001 8151295 8153837 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01009412001 8151295 8153837 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01029609001 20806152 20810746 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of the terminal 1,2-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2). IEA GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity GSVIVG01029609001 20806152 20810746 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01015416001 3457715 3458673 GSVIVG01027479001 16444548 16446819 GSVIVG01033512001 20131148 20138271 GSVIVG01022906001 18151231 18151448 GSVIVG01031850001 4874233 4875367 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01031850001 4874233 4875367 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01031850001 4874233 4875367 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01008054001 6211393 6213589 GSVIVG01038609001 21530831 21531934 GSVIVG01021091001 1391553 1397793 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01021091001 1391553 1397793 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01022558001 5000574 5001313 GSVIVG01003670001 11968241 11971168 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01003670001 11968241 11971168 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01020266001 22076110 22082842 GO:0006525 arginine metabolic process The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01020266001 22076110 22082842 GO:0006525 arginine metabolic process The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid. IEA Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. IEA GO:0008483 transaminase activity GSVIVG01020266001 22076110 22082842 GO:0006525 arginine metabolic process The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01037624001 6323258 6327058 Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01037624001 6323258 6327058 Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01037624001 6323258 6327058 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01037624001 6323258 6327058 Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01036777001 22678798 22680489 GSVIVG01032703001 1382695 1388106 GSVIVG01031466001 18252326 18253568 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01024532001 9099433 9119148 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01024532001 9099433 9119148 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01032542001 28196372 28207993 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01022875001 18497323 18500934 GSVIVG01006611001 27003641 27007080 GO:0006298 mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006611001 27003641 27007080 GO:0006298 mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. IEA Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches. IEA GO:0030983 mismatched DNA binding GSVIVG01006763001 28238724 28243436 GSVIVG01019547001 1521769 1530974 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019547001 1521769 1530974 GO:0006012 galactose metabolic process The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019547001 1521769 1530974 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019547001 1521769 1530974 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019547001 1521769 1530974 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019547001 1521769 1530974 GO:0045226 extracellular polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019547001 1521769 1530974 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: UDP-glucose = UDP-galactose. IEA GO:0003978 UDP-glucose 4-epimerase activity GSVIVG01019547001 1521769 1530974 GO:0006012 galactose metabolic process The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. IEA Catalysis of the reaction: UDP-glucose = UDP-galactose. IEA GO:0003978 UDP-glucose 4-epimerase activity GSVIVG01019547001 1521769 1530974 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: UDP-glucose = UDP-galactose. IEA GO:0003978 UDP-glucose 4-epimerase activity GSVIVG01019547001 1521769 1530974 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: UDP-glucose = UDP-galactose. IEA GO:0003978 UDP-glucose 4-epimerase activity GSVIVG01019547001 1521769 1530974 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of the reaction: UDP-glucose = UDP-galactose. IEA GO:0003978 UDP-glucose 4-epimerase activity GSVIVG01019547001 1521769 1530974 GO:0045226 extracellular polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. IEA Catalysis of the reaction: UDP-glucose = UDP-galactose. IEA GO:0003978 UDP-glucose 4-epimerase activity GSVIVG01019547001 1521769 1530974 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019547001 1521769 1530974 GO:0006012 galactose metabolic process The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019547001 1521769 1530974 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019547001 1521769 1530974 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019547001 1521769 1530974 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019547001 1521769 1530974 GO:0045226 extracellular polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019547001 1521769 1530974 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + NADPH + H+. IEA GO:0008831 dTDP-4-dehydrorhamnose reductase activity GSVIVG01019547001 1521769 1530974 GO:0006012 galactose metabolic process The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. IEA Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + NADPH + H+. IEA GO:0008831 dTDP-4-dehydrorhamnose reductase activity GSVIVG01019547001 1521769 1530974 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + NADPH + H+. IEA GO:0008831 dTDP-4-dehydrorhamnose reductase activity GSVIVG01019547001 1521769 1530974 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + NADPH + H+. IEA GO:0008831 dTDP-4-dehydrorhamnose reductase activity GSVIVG01019547001 1521769 1530974 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + NADPH + H+. IEA GO:0008831 dTDP-4-dehydrorhamnose reductase activity GSVIVG01019547001 1521769 1530974 GO:0045226 extracellular polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. IEA Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + NADPH + H+. IEA GO:0008831 dTDP-4-dehydrorhamnose reductase activity GSVIVG01019547001 1521769 1530974 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01019547001 1521769 1530974 GO:0006012 galactose metabolic process The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01019547001 1521769 1530974 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01019547001 1521769 1530974 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01019547001 1521769 1530974 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01019547001 1521769 1530974 GO:0045226 extracellular polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01019547001 1521769 1530974 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. IEA GO:0016853 isomerase activity GSVIVG01019547001 1521769 1530974 GO:0006012 galactose metabolic process The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. IEA Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. IEA GO:0016853 isomerase activity GSVIVG01019547001 1521769 1530974 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. IEA GO:0016853 isomerase activity GSVIVG01019547001 1521769 1530974 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. IEA GO:0016853 isomerase activity GSVIVG01019547001 1521769 1530974 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. IEA GO:0016853 isomerase activity GSVIVG01019547001 1521769 1530974 GO:0045226 extracellular polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. IEA Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. IEA GO:0016853 isomerase activity GSVIVG01019547001 1521769 1530974 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. IEA GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GSVIVG01019547001 1521769 1530974 GO:0006012 galactose metabolic process The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. IEA Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. IEA GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GSVIVG01019547001 1521769 1530974 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. IEA GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GSVIVG01019547001 1521769 1530974 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. IEA GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GSVIVG01019547001 1521769 1530974 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. IEA GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GSVIVG01019547001 1521769 1530974 GO:0045226 extracellular polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. IEA Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. IEA GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GSVIVG01019547001 1521769 1530974 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01019547001 1521769 1530974 GO:0006012 galactose metabolic process The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01019547001 1521769 1530974 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01019547001 1521769 1530974 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01019547001 1521769 1530974 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01019547001 1521769 1530974 GO:0045226 extracellular polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01036628001 19379393 19383411 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036628001 19379393 19383411 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036628001 19379393 19383411 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036628001 19379393 19383411 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030575001 6851959 6854061 GSVIVG01024761001 7163946 7166177 GSVIVG01011292001 7740880 7741065 GSVIVG01035588001 2549158 2554774 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. IEA GO:0004519 endonuclease activity GSVIVG01015527001 4503500 4504994 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015527001 4503500 4504994 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015527001 4503500 4504994 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01015527001 4503500 4504994 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01015527001 4503500 4504994 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01015527001 4503500 4504994 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01015527001 4503500 4504994 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01015527001 4503500 4504994 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01007764001 9281674 9297710 GSVIVG01008024001 6571630 6582153 GSVIVG01025166001 3815582 3818314 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01030763001 15531046 15531126 GSVIVG01022777001 16442785 16443042 GSVIVG01037356001 15229802 15239741 GSVIVG01023254001 20537712 20538918 GSVIVG01015222001 1922070 1943368 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01015222001 1922070 1943368 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01015222001 1922070 1943368 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01015222001 1922070 1943368 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01015222001 1922070 1943368 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01015222001 1922070 1943368 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01015222001 1922070 1943368 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01015222001 1922070 1943368 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01009347001 7595872 7598628 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01034812001 21957553 21963382 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01034812001 21957553 21963382 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01034812001 21957553 21963382 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01034812001 21957553 21963382 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01034812001 21957553 21963382 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034812001 21957553 21963382 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034812001 21957553 21963382 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01034812001 21957553 21963382 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01030098001 9797689 9800441 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015129001 1284219 1285208 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0000015 phosphopyruvate hydratase complex A multimeric enzyme complex, usually a dimer or an octamer, that catalyzes the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate and water. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01015129001 1284219 1285208 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0000015 phosphopyruvate hydratase complex A multimeric enzyme complex, usually a dimer or an octamer, that catalyzes the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate and water. IEA Catalysis of the reaction: 2-phospho-D-glycerate = phosphoenolpyruvate + H2O. IEA GO:0004634 phosphopyruvate hydratase activity GSVIVG01038708001 20769710 20783861 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01038708001 20769710 20783861 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01038708001 20769710 20783861 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01038708001 20769710 20783861 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01038425001 12071384 12071964 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01034585001 19069469 19069755 GSVIVG01033550001 19830441 19833877 GSVIVG01001191001 962063 965092 GSVIVG01012998001 10418028 10430565 GSVIVG01004884001 16392232 16413875 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function that links a sequence-specific transcription factor to the core RNA polymerase II complex but does not bind DNA itself. IEA GO:0003712 transcription cofactor activity GSVIVG01004884001 16392232 16413875 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025436001 803926 805190 GSVIVG01005850001 22238699 22245271 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01005850001 22238699 22245271 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01036922001 17566264 17566545 GSVIVG01024884001 6242525 6253079 GSVIVG01023732001 10240816 10247373 GSVIVG01013994001 8655843 8657080 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01036364001 4244641 4245609 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01013714001 8296332 8298549 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01013714001 8296332 8298549 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01013714001 8296332 8298549 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01013714001 8296332 8298549 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033176001 8941128 8966253 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033176001 8941128 8966253 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033176001 8941128 8966253 GO:0045226 extracellular polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033176001 8941128 8966253 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033176001 8941128 8966253 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033176001 8941128 8966253 GO:0045226 extracellular polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033176001 8941128 8966253 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + NADPH + H+. IEA GO:0008831 dTDP-4-dehydrorhamnose reductase activity GSVIVG01033176001 8941128 8966253 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + NADPH + H+. IEA GO:0008831 dTDP-4-dehydrorhamnose reductase activity GSVIVG01033176001 8941128 8966253 GO:0045226 extracellular polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. IEA Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + NADPH + H+. IEA GO:0008831 dTDP-4-dehydrorhamnose reductase activity GSVIVG01033176001 8941128 8966253 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01033176001 8941128 8966253 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01033176001 8941128 8966253 GO:0045226 extracellular polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01013708001 2884679 2887841 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01013708001 2884679 2887841 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01013708001 2884679 2887841 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01013708001 2884679 2887841 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01013708001 2884679 2887841 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01013708001 2884679 2887841 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01013708001 2884679 2887841 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01013708001 2884679 2887841 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01013708001 2884679 2887841 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01018452001 14877924 14896569 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01018452001 14877924 14896569 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the transfer of a phosphate group from one position to another within a single molecule. IEA GO:0016868 intramolecular transferase activity, phosphotransferases GSVIVG01018452001 14877924 14896569 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01037881001 6798199 6802367 GSVIVG01011178001 7822419 7828262 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01011178001 7822419 7828262 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds. IEA GO:0015035 protein disulfide oxidoreductase activity GSVIVG01036424001 4963224 4963355 GSVIVG01004040001 14482826 14507756 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018891001 18887824 18891508 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01018891001 18887824 18891508 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01018891001 18887824 18891508 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01018891001 18887824 18891508 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01032398001 26956517 26959918 GSVIVG01004733001 15642099 15642747 GSVIVG01015790001 17468674 17476732 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015790001 17468674 17476732 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01015790001 17468674 17476732 Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01020108001 10275245 10279439 GSVIVG01002699001 35900939 35904485 GSVIVG01020580001 4092469 4097548 GSVIVG01016307001 5301872 5306113 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004185 serine-type carboxypeptidase activity GSVIVG01009095001 4990224 4990518 GSVIVG01029157001 19016841 19019749 GSVIVG01014227001 1674062 1682549 GSVIVG01007951001 7243746 7246234 GSVIVG01034095001 15181403 15189528 GSVIVG01033249001 22205366 22207416 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA GSVIVG01033249001 22205366 22207416 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GSVIVG01022847001 18787732 18788297 GSVIVG01019015001 17749565 17753874 GSVIVG01008401001 2459941 2464219 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01021449001 5488906 5489457 GSVIVG01034602001 14642929 14648913 GSVIVG01025038001 5090705 5091994 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01025038001 5090705 5091994 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01025038001 5090705 5091994 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01025038001 5090705 5091994 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01034344001 17786675 17792361 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01034344001 17786675 17792361 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01034344001 17786675 17792361 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the reaction: ATP + pyruvate = ADP + phosphoenolpyruvate. IEA GO:0004743 pyruvate kinase activity GSVIVG01034344001 17786675 17792361 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Interacting selectively and non-covalently with potassium (K+) ions. IEA GO:0030955 potassium ion binding GSVIVG01023204001 21126928 21127032 GSVIVG01021670001 9034552 9050667 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with double-stranded RNA. IEA GO:0003725 double-stranded RNA binding GSVIVG01021670001 9034552 9050667 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with double-stranded RNA. IEA GO:0003725 double-stranded RNA binding GSVIVG01021670001 9034552 9050667 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01021670001 9034552 9050667 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01015633001 14489675 14495034 GO:0015976 carbon utilization A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbon sources and then activates genes to scavenge the last traces of the primary carbon source and to transport and metabolize alternative carbon sources such as carbon dioxide or carbonic acid. The utilization process begins when the cell or organism detects carbon levels, includes the activation of genes whose products detect, transport or metabolize carbon-containing substances, and ends when carbon is incorporated into the cell or organism's metabolism. IEA Catalysis of the reaction: H2CO3 = CO2 + H2O. IEA GO:0004089 carbonate dehydratase activity GSVIVG01015633001 14489675 14495034 GO:0015976 carbon utilization A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbon sources and then activates genes to scavenge the last traces of the primary carbon source and to transport and metabolize alternative carbon sources such as carbon dioxide or carbonic acid. The utilization process begins when the cell or organism detects carbon levels, includes the activation of genes whose products detect, transport or metabolize carbon-containing substances, and ends when carbon is incorporated into the cell or organism's metabolism. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01030576001 6854997 6857913 GSVIVG01015596001 5369130 5370256 GSVIVG01003689001 12233890 12237530 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01003689001 12233890 12237530 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01036032001 7584559 7587444 GSVIVG01002341001 34219658 34220811 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. IEA GO:0016597 amino acid binding GSVIVG01022833001 18957381 18962031 GSVIVG01035736001 3800995 3812258 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032643001 1892801 1901465 GSVIVG01027777001 7624056 7625328 GSVIVG01004879001 16356704 16357237 GSVIVG01010816001 22951895 22973624 GSVIVG01013604001 1175370 1210561 GSVIVG01018419001 9314196 9317299 GO:0001539 ciliary or flagellar motility Cell motility due to movement of cilia or flagella. IEA GO:0009288 bacterial-type flagellum A motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope. IEA Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate. IEA GO:0003774 motor activity GSVIVG01014943001 12496229 12500010 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01014943001 12496229 12500010 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01014943001 12496229 12500010 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01014943001 12496229 12500010 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01028629001 11136462 11139614 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01028629001 11136462 11139614 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01028629001 11136462 11139614 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028629001 11136462 11139614 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032180001 21777120 21783196 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with follicle-stimulating hormone to initiate a change in cell activity. IEA GO:0004963 follicle-stimulating hormone receptor activity GSVIVG01032180001 21777120 21783196 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with follicle-stimulating hormone to initiate a change in cell activity. IEA GO:0004963 follicle-stimulating hormone receptor activity GSVIVG01032180001 21777120 21783196 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with follicle-stimulating hormone to initiate a change in cell activity. IEA GO:0004963 follicle-stimulating hormone receptor activity GSVIVG01032180001 21777120 21783196 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032180001 21777120 21783196 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032180001 21777120 21783196 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032180001 21777120 21783196 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032180001 21777120 21783196 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032180001 21777120 21783196 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024266001 370309 399658 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives. IEA GO:0018024 histone-lysine N-methyltransferase activity GSVIVG01029797001 14887374 14898278 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01029797001 14887374 14898278 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01029797001 14887374 14898278 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01029797001 14887374 14898278 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029797001 14887374 14898278 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011940001 2791814 2796602 GSVIVG01025801001 11729094 11732881 Stops, prevents or reduces the activity of a cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004869 cysteine-type endopeptidase inhibitor activity GSVIVG01017301001 6491598 6496034 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01017250001 5894753 5900074 GSVIVG01026037001 25457568 25460616 GSVIVG01013370001 908408 914042 GSVIVG01029831001 256715 275426 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029831001 256715 275426 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01029831001 256715 275426 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nucleotidyl group to a reactant. IEA GO:0016779 nucleotidyltransferase activity GSVIVG01027402001 17015443 17018629 GSVIVG01027715001 7030506 7031307 GSVIVG01029746001 14064588 14067060 GO:0048268 clathrin coat assembly The process by which clathrin triskelia are assembled into the ordered structure known as a clathrin cage. IEA GO:0030118 clathrin coat A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes. IEA Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester. IEA GO:0005543 phospholipid binding GSVIVG01029746001 14064588 14067060 GO:0048268 clathrin coat assembly The process by which clathrin triskelia are assembled into the ordered structure known as a clathrin cage. IEA GO:0030118 clathrin coat A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes. IEA Interacting selectively and non-covalently with phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. IEA GO:0005545 phosphatidylinositol binding GSVIVG01029746001 14064588 14067060 GO:0048268 clathrin coat assembly The process by which clathrin triskelia are assembled into the ordered structure known as a clathrin cage. IEA GO:0030118 clathrin coat A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes. IEA Interacting selectively and non-covalently with a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles. IEA GO:0030276 clathrin binding GSVIVG01009360001 7746214 7747271 GSVIVG01033683001 18708033 18708266 GSVIVG01029106001 19627840 19636657 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01029106001 19627840 19636657 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01029106001 19627840 19636657 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01029106001 19627840 19636657 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01029106001 19627840 19636657 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01029106001 19627840 19636657 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01029106001 19627840 19636657 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029106001 19627840 19636657 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028837001 18247257 18248671 GSVIVG01026929001 19327772 19328216 GSVIVG01019031001 17567651 17568947 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01022913001 18115243 18122170 Functions in the storage of nutritious substrates. IEA GO:0045735 nutrient reservoir activity GSVIVG01000748001 344187 358022 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000748001 344187 358022 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01036953001 9707224 9708876 GSVIVG01019371001 196036 237854 GSVIVG01018016001 5501527 5502959 GSVIVG01029801001 15033406 15034827 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01016695001 426908 429911 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01016695001 426908 429911 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01016695001 426908 429911 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01016695001 426908 429911 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015935 small ribosomal subunit The smaller of the two subunits of a ribosome. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01016695001 426908 429911 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01001845001 26263495 26271378 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01001845001 26263495 26271378 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001845001 26263495 26271378 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01032718001 1284757 1285585 GSVIVG01037485001 12884023 12898126 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01037485001 12884023 12898126 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01037485001 12884023 12898126 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01037485001 12884023 12898126 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01024269001 434455 434661 GSVIVG01006029001 23313548 23317973 GSVIVG01017155001 4813815 4820062 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017155001 4813815 4820062 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01030857001 17711147 17762011 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01030857001 17711147 17762011 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01030857001 17711147 17762011 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01030857001 17711147 17762011 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01008600001 512336 514836 GO:0006626 protein targeting to mitochondrion The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein. IEA GO:0042719 mitochondrial intermembrane space protein transporter complex Soluble complex of the mitochondrial intermembrane space composed of various combinations of small Tim proteins; acts as a protein transporter to guide proteins to the Tim22 complex for insertion into the mitochondrial inner membrane. IEA GSVIVG01008600001 512336 514836 GO:0045039 protein import into mitochondrial inner membrane The import of proteins into the mitochondria inner membrane. Inner membrane proteins are first imported into the matrix space where the matrix-targeting sequence is removed; how these proteins then are incorporated into the inner membrane is not known. IEA GO:0042719 mitochondrial intermembrane space protein transporter complex Soluble complex of the mitochondrial intermembrane space composed of various combinations of small Tim proteins; acts as a protein transporter to guide proteins to the Tim22 complex for insertion into the mitochondrial inner membrane. IEA GSVIVG01014324001 2643180 2661593 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01014324001 2643180 2661593 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01003189001 7724709 7738583 GSVIVG01028618001 10872303 10894205 GO:0009405 pathogenesis The set of specific processes that generate the ability of an organism to cause disease in another. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA GSVIVG01024951001 5730702 5734615 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01024951001 5730702 5734615 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01024951001 5730702 5734615 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01024951001 5730702 5734615 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020106001 10281464 10283659 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar. IEA GO:0008375 acetylglucosaminyltransferase activity GSVIVG01019390001 251332 253144 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01019390001 251332 253144 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01033405001 20936615 20939247 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01033405001 20936615 20939247 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01021541001 6827854 6838091 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01021541001 6827854 6838091 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01021541001 6827854 6838091 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01021541001 6827854 6838091 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01021541001 6827854 6838091 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01021541001 6827854 6838091 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01021541001 6827854 6838091 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021541001 6827854 6838091 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038546001 21975853 21979103 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the reaction: pectin + n H2O = n methanol + pectate. IEA GO:0030599 pectinesterase activity GSVIVG01032094001 22760114 22762348 GSVIVG01018115001 6654968 6660852 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01015433001 3618074 3638017 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01000696001 15754698 15779104 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin. IEA GO:0004221 ubiquitin thiolesterase activity GSVIVG01000696001 15754698 15779104 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01015182001 1617309 1617821 GSVIVG01025344001 1704251 1743604 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025344001 1704251 1743604 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01025344001 1704251 1743604 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01024564001 8827905 8832792 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01028865001 17990806 18010705 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028865001 17990806 18010705 GO:0008360 regulation of cell shape Any process that modulates the surface configuration of a cell. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028865001 17990806 18010705 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028865001 17990806 18010705 GO:0009252 peptidoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028865001 17990806 18010705 GO:0009273 peptidoglycan-based cell wall biogenesis The chemical reactions and pathways resulting in the formation of the peptidoglycan-based cell wall. An example of this process is found in Escherichia coli. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028865001 17990806 18010705 GO:0051301 cell division The process resulting in the physical partitioning and separation of a cell into daughter cells. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028865001 17990806 18010705 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028865001 17990806 18010705 GO:0008360 regulation of cell shape Any process that modulates the surface configuration of a cell. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028865001 17990806 18010705 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028865001 17990806 18010705 GO:0009252 peptidoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028865001 17990806 18010705 GO:0009273 peptidoglycan-based cell wall biogenesis The chemical reactions and pathways resulting in the formation of the peptidoglycan-based cell wall. An example of this process is found in Escherichia coli. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028865001 17990806 18010705 GO:0051301 cell division The process resulting in the physical partitioning and separation of a cell into daughter cells. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028865001 17990806 18010705 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028865001 17990806 18010705 GO:0008360 regulation of cell shape Any process that modulates the surface configuration of a cell. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028865001 17990806 18010705 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028865001 17990806 18010705 GO:0009252 peptidoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028865001 17990806 18010705 GO:0009273 peptidoglycan-based cell wall biogenesis The chemical reactions and pathways resulting in the formation of the peptidoglycan-based cell wall. An example of this process is found in Escherichia coli. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028865001 17990806 18010705 GO:0051301 cell division The process resulting in the physical partitioning and separation of a cell into daughter cells. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028865001 17990806 18010705 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + UDP-N-acetylmuramoyl + L-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine. IEA GO:0008763 UDP-N-acetylmuramate-L-alanine ligase activity GSVIVG01028865001 17990806 18010705 GO:0008360 regulation of cell shape Any process that modulates the surface configuration of a cell. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + UDP-N-acetylmuramoyl + L-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine. IEA GO:0008763 UDP-N-acetylmuramate-L-alanine ligase activity GSVIVG01028865001 17990806 18010705 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + UDP-N-acetylmuramoyl + L-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine. IEA GO:0008763 UDP-N-acetylmuramate-L-alanine ligase activity GSVIVG01028865001 17990806 18010705 GO:0009252 peptidoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + UDP-N-acetylmuramoyl + L-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine. IEA GO:0008763 UDP-N-acetylmuramate-L-alanine ligase activity GSVIVG01028865001 17990806 18010705 GO:0009273 peptidoglycan-based cell wall biogenesis The chemical reactions and pathways resulting in the formation of the peptidoglycan-based cell wall. An example of this process is found in Escherichia coli. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + UDP-N-acetylmuramoyl + L-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine. IEA GO:0008763 UDP-N-acetylmuramate-L-alanine ligase activity GSVIVG01028865001 17990806 18010705 GO:0051301 cell division The process resulting in the physical partitioning and separation of a cell into daughter cells. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + UDP-N-acetylmuramoyl + L-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine. IEA GO:0008763 UDP-N-acetylmuramate-L-alanine ligase activity GSVIVG01028865001 17990806 18010705 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01028865001 17990806 18010705 GO:0008360 regulation of cell shape Any process that modulates the surface configuration of a cell. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01028865001 17990806 18010705 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01028865001 17990806 18010705 GO:0009252 peptidoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01028865001 17990806 18010705 GO:0009273 peptidoglycan-based cell wall biogenesis The chemical reactions and pathways resulting in the formation of the peptidoglycan-based cell wall. An example of this process is found in Escherichia coli. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01028865001 17990806 18010705 GO:0051301 cell division The process resulting in the physical partitioning and separation of a cell into daughter cells. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01025798001 11754199 11756598 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01023235001 20814794 20831239 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01023235001 20814794 20831239 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01023235001 20814794 20831239 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01023235001 20814794 20831239 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021054001 14517473 14521074 Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum. IEA GO:0003993 acid phosphatase activity GSVIVG01021054001 14517473 14521074 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01021054001 14517473 14521074 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01004740001 15701081 15701209 GSVIVG01031297001 568600 572639 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GSVIVG01010724001 12884928 12887099 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01035902001 5596166 5598770 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01026942001 19199215 19206926 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01026942001 19199215 19206926 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01026942001 19199215 19206926 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01026942001 19199215 19206926 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01035836001 4762276 4774766 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01035836001 4762276 4774766 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035836001 4762276 4774766 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01029467001 22509692 22512644 GSVIVG01022010001 4335959 4354077 GO:0007283 spermatogenesis The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01022010001 4335959 4354077 GO:0007283 spermatogenesis The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01022010001 4335959 4354077 GO:0007283 spermatogenesis The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01022010001 4335959 4354077 GO:0007283 spermatogenesis The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01022010001 4335959 4354077 GO:0007283 spermatogenesis The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01022010001 4335959 4354077 GO:0007283 spermatogenesis The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012182001 729267 731550 GSVIVG01034645001 13478268 13512087 GO:0006887 exocytosis A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell. This is the process whereby most molecules are secreted from eukaryotic cells. IEA GO:0000145 exocyst A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals. IEA GSVIVG01021477001 5979865 5980905 GSVIVG01000945001 22164908 22165280 GSVIVG01023756001 10678387 10678500 GSVIVG01012129001 1191519 1197413 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GSVIVG01031394001 19167363 19174033 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01031394001 19167363 19174033 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01011786001 4151719 4154782 GO:0016480 negative regulation of transcription from RNA polymerase III promoter Any process that stops, prevents or reduces the frequency, rate or extent of transcription from an RNA polymerase III promoter. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01032434001 27359651 27359848 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005746 mitochondrial respiratory chain The protein complexes that form the mitochondrial electron transport system (the respiratory chain), associated with the inner mitochondrial membrane. The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O. IEA GO:0004129 cytochrome-c oxidase activity GSVIVG01028889001 17800178 17808482 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01028763001 19109676 19118799 GSVIVG01018762001 20111685 20116188 GSVIVG01016408001 4180057 4183444 GSVIVG01032218001 13105567 13107504 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01032218001 13105567 13107504 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01032218001 13105567 13107504 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01032218001 13105567 13107504 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01029329001 14425930 14430764 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GSVIVG01008426001 2199755 2201874 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01008426001 2199755 2201874 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01008426001 2199755 2201874 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01008426001 2199755 2201874 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01008426001 2199755 2201874 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01008426001 2199755 2201874 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01008426001 2199755 2201874 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01008426001 2199755 2201874 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01008426001 2199755 2201874 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01008426001 2199755 2201874 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01008426001 2199755 2201874 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01008426001 2199755 2201874 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01008426001 2199755 2201874 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01008426001 2199755 2201874 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01008426001 2199755 2201874 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01008426001 2199755 2201874 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01008426001 2199755 2201874 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01008426001 2199755 2201874 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01008426001 2199755 2201874 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01008426001 2199755 2201874 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01008426001 2199755 2201874 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01008426001 2199755 2201874 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01008426001 2199755 2201874 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01008426001 2199755 2201874 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01008426001 2199755 2201874 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01008426001 2199755 2201874 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01008426001 2199755 2201874 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01025135001 4058152 4060361 Catalysis of the reaction: ATP + shikimate = ADP + shikimate 3-phosphate. IEA GO:0004765 shikimate kinase activity GSVIVG01025135001 4058152 4060361 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026205001 14042781 14046546 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01026205001 14042781 14046546 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01026205001 14042781 14046546 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01026205001 14042781 14046546 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01026205001 14042781 14046546 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017606001 1961984 1962270 GSVIVG01014836001 10385173 10388468 GSVIVG01036940001 17263497 17294017 GSVIVG01037355001 15266470 15276851 GSVIVG01003776001 12544673 12545868 GSVIVG01036930001 17439361 17448268 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01030926001 19129279 19131490 GSVIVG01028308001 5960288 5965597 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01014562001 5187119 5188831 Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01014562001 5187119 5188831 Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01029648001 20236918 20239206 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01029648001 20236918 20239206 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01006766001 28274099 28277346 GSVIVG01009991001 13199060 13200267 GSVIVG01021147001 1838163 1840711 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01011607001 6024539 6025674 GSVIVG01011450001 29758937 29764002 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01011450001 29758937 29764002 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01036637001 19525581 19528994 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01036637001 19525581 19528994 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01036637001 19525581 19528994 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01036637001 19525581 19528994 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036637001 19525581 19528994 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017264001 6064996 6065905 GSVIVG01028904001 17676108 17676678 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028904001 17676108 17676678 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028904001 17676108 17676678 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01027917001 9396155 9400042 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01027917001 9396155 9400042 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01009270001 6840931 6841164 GSVIVG01030524001 6463726 6469557 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA GSVIVG01011500001 30055920 30065172 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01028938001 17218593 17219856 GSVIVG01010154001 16476402 16490940 GO:0008654 phospholipid biosynthetic process The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor). IEA GO:0016780 phosphotransferase activity, for other substituted phosphate groups GSVIVG01026510001 22455730 22458751 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026510001 22455730 22458751 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026510001 22455730 22458751 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01026510001 22455730 22458751 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01026510001 22455730 22458751 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026510001 22455730 22458751 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026510001 22455730 22458751 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01026510001 22455730 22458751 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01026510001 22455730 22458751 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01026510001 22455730 22458751 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01026510001 22455730 22458751 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01026510001 22455730 22458751 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01038082001 17668878 17700404 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin. IEA GO:0004221 ubiquitin thiolesterase activity GSVIVG01021096001 1419186 1428789 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01002737001 36285499 36292032 GSVIVG01025474001 511211 518276 GSVIVG01028139001 4115584 4130394 GSVIVG01015090001 957946 962362 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01026742001 5994639 5997392 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026742001 5994639 5997392 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003762001 12461386 12462096 GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA GSVIVG01023027001 16683847 16684128 GSVIVG01034309001 14658947 14663881 GSVIVG01038572001 21771556 21776235 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01038572001 21771556 21776235 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. IEA GO:0004722 protein serine/threonine phosphatase activity GSVIVG01003797001 191354 192873 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01003797001 191354 192873 Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01037070001 8209417 8210614 GSVIVG01015854001 18431658 18446321 GSVIVG01022499001 3970544 3970988 GSVIVG01037660001 6628747 6632800 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01037660001 6628747 6632800 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01035411001 1094385 1098549 GSVIVG01025441001 796135 797547 GSVIVG01008633001 250000 257710 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01008633001 250000 257710 GO:0016311 dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01008633001 250000 257710 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. IEA GO:0004725 protein tyrosine phosphatase activity GSVIVG01008633001 250000 257710 GO:0016311 dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. IEA GO:0004725 protein tyrosine phosphatase activity GSVIVG01008633001 250000 257710 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: protein serine/threonine/tyrosine phosphate + H2O = protein serine/threonine/tyrosine + phosphate. IEA GO:0008138 protein tyrosine/serine/threonine phosphatase activity GSVIVG01008633001 250000 257710 GO:0016311 dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: protein serine/threonine/tyrosine phosphate + H2O = protein serine/threonine/tyrosine + phosphate. IEA GO:0008138 protein tyrosine/serine/threonine phosphatase activity GSVIVG01008633001 250000 257710 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008633001 250000 257710 GO:0016311 dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008633001 250000 257710 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. IEA GO:0016791 phosphatase activity GSVIVG01008633001 250000 257710 GO:0016311 dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. IEA GO:0016791 phosphatase activity GSVIVG01011829001 3786769 3798441 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01005339001 39770110 39771523 GSVIVG01027258001 17533272 17534649 GSVIVG01037636001 6423469 6435344 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0031361 integral to thylakoid membrane Penetrating at least one phospholipid bilayer of a thylakoid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01037636001 6423469 6435344 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0031361 integral to thylakoid membrane Penetrating at least one phospholipid bilayer of a thylakoid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01037636001 6423469 6435344 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0031361 integral to thylakoid membrane Penetrating at least one phospholipid bilayer of a thylakoid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01037636001 6423469 6435344 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0031361 integral to thylakoid membrane Penetrating at least one phospholipid bilayer of a thylakoid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037636001 6423469 6435344 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0031361 integral to thylakoid membrane Penetrating at least one phospholipid bilayer of a thylakoid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01037636001 6423469 6435344 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0031361 integral to thylakoid membrane Penetrating at least one phospholipid bilayer of a thylakoid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01037636001 6423469 6435344 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0031361 integral to thylakoid membrane Penetrating at least one phospholipid bilayer of a thylakoid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01021591001 7648052 7656625 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021591001 7648052 7656625 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021591001 7648052 7656625 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01021591001 7648052 7656625 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01033420001 20850471 20854037 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01033420001 20850471 20854037 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01037913001 6391621 6395007 GO:0009086 methionine biosynthetic process The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. IEA Catalysis of the reaction: ATP + S5-methyl-5-thio-D-ribose = ADP + S5-methyl-5-thio-D-ribose 1-phosphate. IEA GO:0046522 S-methyl-5-thioribose kinase activity GSVIVG01030734001 14714661 14767459 GSVIVG01015626001 14310744 14311619 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01015626001 14310744 14311619 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01015626001 14310744 14311619 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01015626001 14310744 14311619 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01015626001 14310744 14311619 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01015626001 14310744 14311619 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01015626001 14310744 14311619 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01015626001 14310744 14311619 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01015626001 14310744 14311619 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01015626001 14310744 14311619 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01015626001 14310744 14311619 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01015626001 14310744 14311619 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01015626001 14310744 14311619 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01015626001 14310744 14311619 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01015626001 14310744 14311619 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01015626001 14310744 14311619 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01015626001 14310744 14311619 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01015626001 14310744 14311619 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01024030001 1647090 1650863 GSVIVG01021598001 7849963 7855657 GO:0009416 response to light stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01021598001 7849963 7855657 GO:0009416 response to light stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018000001 5385922 5387853 GSVIVG01000128001 15497543 15499633 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000128001 15497543 15499633 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01000128001 15497543 15499633 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01009430001 8278058 8279676 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01012943001 14091301 14091438 GSVIVG01028455001 7819695 7843397 GSVIVG01005240001 19755114 19755260 GSVIVG01024584001 8617952 8635385 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01022365001 19064850 19065617 GSVIVG01031710001 3628436 3643357 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01036676001 20168133 20173478 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01036676001 20168133 20173478 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01036676001 20168133 20173478 Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01000065001 3187971 3190660 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with manganese (Mn) ions. IEA GO:0030145 manganese ion binding GSVIVG01000065001 3187971 3190660 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Functions in the storage of nutritious substrates. IEA GO:0045735 nutrient reservoir activity GSVIVG01012682001 618603 621252 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01012682001 618603 621252 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01024066001 1397564 1400843 Catalysis of the transfer of the amide nitrogen of glutamine to a variety of substrates. GATases catalyze two separate reactions at two active sites, which are located either on a single polypeptide chain or on different subunits. In the glutaminase reaction, glutamine is hydrolyzed to glutamate and ammonia, which is added to an acceptor substrate in the synthase reaction. IEA GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor GSVIVG01013754001 7933692 7941206 GSVIVG01007137001 30320938 30327831 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01007137001 30320938 30327831 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01007137001 30320938 30327831 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01007137001 30320938 30327831 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026314001 13511540 13532182 GSVIVG01019413001 459804 461157 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01017828001 3838328 3838420 GSVIVG01035786001 4286128 4295628 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01035786001 4286128 4295628 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035786001 4286128 4295628 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01035786001 4286128 4295628 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01033559001 19753244 19757120 GSVIVG01025536001 14233211 14235923 GSVIVG01026577001 21481688 21489122 GSVIVG01007268001 1181039 1181524 GSVIVG01026151001 13061773 13065326 GSVIVG01016090001 18729892 18730538 GSVIVG01017451001 8718947 8725743 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01038682001 21040651 21042003 GSVIVG01009832001 11630982 11633211 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01009832001 11630982 11633211 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01009832001 11630982 11633211 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and carries out proton transport across a membrane. The proton-transporting domain (F0, V0, or A0) includes integral and peripheral membrane proteins. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01009832001 11630982 11633211 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0033179 proton-transporting V-type ATPase, V0 domain A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01009832001 11630982 11633211 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01009832001 11630982 11633211 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01009832001 11630982 11633211 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and carries out proton transport across a membrane. The proton-transporting domain (F0, V0, or A0) includes integral and peripheral membrane proteins. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01009832001 11630982 11633211 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033179 proton-transporting V-type ATPase, V0 domain A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01009832001 11630982 11633211 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01009832001 11630982 11633211 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01009832001 11630982 11633211 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and carries out proton transport across a membrane. The proton-transporting domain (F0, V0, or A0) includes integral and peripheral membrane proteins. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01009832001 11630982 11633211 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033179 proton-transporting V-type ATPase, V0 domain A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01009832001 11630982 11633211 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01009832001 11630982 11633211 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01009832001 11630982 11633211 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and carries out proton transport across a membrane. The proton-transporting domain (F0, V0, or A0) includes integral and peripheral membrane proteins. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01009832001 11630982 11633211 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033179 proton-transporting V-type ATPase, V0 domain A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01012952001 14209990 14211405 GSVIVG01016475001 3557849 3558613 GSVIVG01019702001 2569665 2576046 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01026070001 24961738 24968461 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01026070001 24961738 24968461 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01026070001 24961738 24968461 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01026070001 24961738 24968461 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01026070001 24961738 24968461 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01026070001 24961738 24968461 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01027356001 15912641 15914421 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Stops, prevents or reduces the activity of an enzyme. IEA GO:0004857 enzyme inhibitor activity GSVIVG01027356001 15912641 15914421 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the reaction: pectin + n H2O = n methanol + pectate. IEA GO:0030599 pectinesterase activity GSVIVG01024502001 3412005 3415385 GSVIVG01015712001 16194423 16196702 GSVIVG01013844001 5145819 5146509 GSVIVG01031090001 2468815 2470218 GSVIVG01022464001 3355789 3361653 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01022464001 3355789 3361653 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01022464001 3355789 3361653 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01027759001 7461185 7463778 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01027759001 7461185 7463778 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01003115001 7370340 7373521 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003115001 7370340 7373521 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. IEA GO:0004722 protein serine/threonine phosphatase activity GSVIVG01018708001 10885019 10885186 GSVIVG01034705001 8077386 8083694 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01023500001 10908555 10908722 GSVIVG01038113001 23553731 23559206 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01038113001 23553731 23559206 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01038113001 23553731 23559206 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01038113001 23553731 23559206 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. IEA GO:0005179 hormone activity GSVIVG01038113001 23553731 23559206 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. IEA GO:0005179 hormone activity GSVIVG01038113001 23553731 23559206 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. IEA GO:0005179 hormone activity GSVIVG01031586001 18498543 18499178 GSVIVG01016653001 141171 143704 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion. IEA GO:0004806 triglyceride lipase activity GSVIVG01003307001 8835989 8839848 GSVIVG01033719001 18359686 18365996 GSVIVG01033471001 20420222 20424817 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01033471001 20420222 20424817 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01014650001 8223431 8225593 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01014650001 8223431 8225593 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01010374001 19925332 19930565 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01010374001 19925332 19930565 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01022524001 4329896 4341074 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01022524001 4329896 4341074 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01022524001 4329896 4341074 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01022524001 4329896 4341074 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01022524001 4329896 4341074 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01022524001 4329896 4341074 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018771001 20080786 20081788 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01018771001 20080786 20081788 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01016725001 669592 676010 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01028143001 4168620 4171900 GSVIVG01012510001 291784 318115 GSVIVG01031019001 21011304 21020459 GSVIVG01017036001 3678536 3681367 GSVIVG01025389001 1161447 1165229 GSVIVG01018417001 9353126 9353986 GSVIVG01016801001 1517253 1523754 GSVIVG01003710001 15143050 15149586 GSVIVG01032395001 26933060 26943061 GSVIVG01011673001 5326469 5334423 GSVIVG01020990001 15873533 15875532 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin. IEA GO:0004221 ubiquitin thiolesterase activity GSVIVG01032884001 23789690 23790125 Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01032884001 23789690 23790125 Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01029330001 14461861 14465916 GSVIVG01016877001 2181860 2186992 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016877001 2181860 2186992 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01025601001 13690986 13694722 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01001082001 22467218 22468254 GSVIVG01025335001 1905314 1913636 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025335001 1905314 1913636 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025335001 1905314 1913636 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025335001 1905314 1913636 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025335001 1905314 1913636 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025335001 1905314 1913636 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01027838001 8485998 8487467 GSVIVG01026989001 18773149 18778109 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01015345001 2836810 2846560 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01003492001 10724070 10728783 GSVIVG01000140001 15582245 15586140 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide. IEA GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides GSVIVG01007116001 30130260 30134305 GSVIVG01025642001 13391525 13401844 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01004860001 154711 169965 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. IEA GO:0005516 calmodulin binding GSVIVG01004860001 154711 169965 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01036056001 21308358 21309826 GSVIVG01012753001 24000434 24001505 GSVIVG01012909001 13299951 13308122 GSVIVG01019132001 16391582 16402392 GSVIVG01029639001 20310330 20310536 GSVIVG01003341001 9174934 9175305 GSVIVG01019739001 2874833 2882840 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01019739001 2874833 2882840 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01019739001 2874833 2882840 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01019739001 2874833 2882840 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011012001 2216256 2220715 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01011012001 2216256 2220715 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01011012001 2216256 2220715 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01011012001 2216256 2220715 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01011012001 2216256 2220715 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01011012001 2216256 2220715 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01011012001 2216256 2220715 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01011012001 2216256 2220715 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01011012001 2216256 2220715 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01011012001 2216256 2220715 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01011012001 2216256 2220715 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01011012001 2216256 2220715 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01011012001 2216256 2220715 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01011012001 2216256 2220715 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01011012001 2216256 2220715 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01011012001 2216256 2220715 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01011012001 2216256 2220715 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01011012001 2216256 2220715 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01037825001 7441440 7444729 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01037825001 7441440 7444729 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01037825001 7441440 7444729 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01026447001 23547256 23557704 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026447001 23547256 23557704 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01028240001 4876033 4878048 GSVIVG01019727001 2774654 2783052 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01019727001 2774654 2783052 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01019727001 2774654 2783052 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01019727001 2774654 2783052 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028558001 9782942 9790480 GO:0007067 mitosis A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell. IEA GO:0005681 spliceosomal complex Any of a series of ribonucleoprotein complexes that contain RNA and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the splicing of a messenger RNA primary transcript to excise an intron. IEA GSVIVG01024380001 1769338 1774199 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion. IEA GO:0005484 SNAP receptor activity GSVIVG01024380001 1769338 1774199 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion. IEA GO:0005484 SNAP receptor activity GSVIVG01024380001 1769338 1774199 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01024380001 1769338 1774199 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01002513001 35144392 35145351 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01002513001 35144392 35145351 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001696001 12187830 12194131 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01007600001 11406397 11410361 GO:0007154 cell communication Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. IEA GSVIVG01007600001 11406397 11410361 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GSVIVG01012654001 378074 381231 GO:0009168 purine ribonucleoside monophosphate biosynthetic process The chemical reactions and pathways resulting in the formation of purine ribonucleoside monophosphate, a glycosamine consisting of a purine base linked to a ribose sugar esterified with phosphate on its glycose moiety. IEA Catalysis of the removal of an amino group from a substrate, producing ammonia (NH3). IEA GO:0019239 deaminase activity GSVIVG01002259001 33744690 33750941 GO:0006631 fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor. IEA GO:0003995 acyl-CoA dehydrogenase activity GSVIVG01002259001 33744690 33750941 GO:0006635 fatty acid beta-oxidation A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor. IEA GO:0003995 acyl-CoA dehydrogenase activity GSVIVG01002259001 33744690 33750941 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor. IEA GO:0003995 acyl-CoA dehydrogenase activity GSVIVG01002259001 33744690 33750941 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor. IEA GO:0003995 acyl-CoA dehydrogenase activity GSVIVG01002259001 33744690 33750941 GO:0006631 fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Catalysis of the reaction: acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2. IEA GO:0003997 acyl-CoA oxidase activity GSVIVG01002259001 33744690 33750941 GO:0006635 fatty acid beta-oxidation A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Catalysis of the reaction: acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2. IEA GO:0003997 acyl-CoA oxidase activity GSVIVG01002259001 33744690 33750941 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Catalysis of the reaction: acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2. IEA GO:0003997 acyl-CoA oxidase activity GSVIVG01002259001 33744690 33750941 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Catalysis of the reaction: acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2. IEA GO:0003997 acyl-CoA oxidase activity GSVIVG01002259001 33744690 33750941 GO:0006631 fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01002259001 33744690 33750941 GO:0006635 fatty acid beta-oxidation A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01002259001 33744690 33750941 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01002259001 33744690 33750941 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01002259001 33744690 33750941 GO:0006631 fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GSVIVG01002259001 33744690 33750941 GO:0006635 fatty acid beta-oxidation A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GSVIVG01002259001 33744690 33750941 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GSVIVG01002259001 33744690 33750941 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GSVIVG01002259001 33744690 33750941 GO:0006631 fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01002259001 33744690 33750941 GO:0006635 fatty acid beta-oxidation A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01002259001 33744690 33750941 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01002259001 33744690 33750941 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01034837001 22454190 22454823 GSVIVG01028293001 5816980 5828131 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion. IEA GO:0004806 triglyceride lipase activity GSVIVG01028243001 4889158 4890220 GO:0000272 polysaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01028243001 4889158 4890220 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01028243001 4889158 4890220 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01028243001 4889158 4890220 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01028243001 4889158 4890220 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01028243001 4889158 4890220 GO:0000272 polysaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01028243001 4889158 4890220 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01028243001 4889158 4890220 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01028243001 4889158 4890220 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01028243001 4889158 4890220 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01028243001 4889158 4890220 GO:0000272 polysaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01028243001 4889158 4890220 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01028243001 4889158 4890220 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01028243001 4889158 4890220 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01028243001 4889158 4890220 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01014341001 2793368 2811295 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01014341001 2793368 2811295 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01014341001 2793368 2811295 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01014341001 2793368 2811295 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01014341001 2793368 2811295 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014341001 2793368 2811295 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01027319001 16626501 16626569 GSVIVG01019785001 3274708 3276088 GSVIVG01037976001 11935213 11941479 GSVIVG01035268001 11655385 11655702 GSVIVG01029735001 13898920 13916251 GSVIVG01036462001 22333406 22334765 GSVIVG01010395001 20143753 20144505 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010395001 20143753 20144505 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033032001 25213227 25214584 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01009269001 6835810 6836625 GSVIVG01012126001 1211163 1211513 GSVIVG01029925001 1542337 1543292 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016651 oxidoreductase activity, acting on NADH or NADPH GSVIVG01029925001 1542337 1543292 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds. IEA GO:0048038 quinone binding GSVIVG01029925001 1542337 1543292 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01025650001 13311735 13313191 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01025650001 13311735 13313191 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01025650001 13311735 13313191 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01025650001 13311735 13313191 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01029722001 13761512 13762567 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01029722001 13761512 13762567 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01029722001 13761512 13762567 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01029722001 13761512 13762567 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008789001 2086364 2087547 GSVIVG01012404001 514820 515990 GSVIVG01006872001 28733757 28737233 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01006872001 28733757 28737233 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01006872001 28733757 28737233 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01006872001 28733757 28737233 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034182001 14588226 14589921 GSVIVG01022444001 3106680 3107944 GSVIVG01024034001 1595361 1600111 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GSVIVG01006218001 23741854 23743883 GO:0006461 protein complex assembly The aggregation, arrangement and bonding together of a set of components to form a protein complex. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells. IEA GO:0015232 heme transporter activity GSVIVG01006218001 23741854 23743883 GO:0008535 respiratory chain complex IV assembly The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase), the terminal member of the respiratory chain of the mitochondrion and some aerobic bacteria. Cytochrome c oxidases are multi-subunit enzymes containing from 13 subunits in the mammalian mitochondrial form to 3-4 subunits in the bacterial forms. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells. IEA GO:0015232 heme transporter activity GSVIVG01006218001 23741854 23743883 GO:0015886 heme transport The directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells. IEA GO:0015232 heme transporter activity GSVIVG01006218001 23741854 23743883 GO:0017004 cytochrome complex assembly The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells. IEA GO:0015232 heme transporter activity GSVIVG01021814001 7031136 7035738 GSVIVG01014043001 9918575 9918806 GSVIVG01013742001 7999869 8002071 GSVIVG01019878001 4150397 4152247 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019878001 4150397 4152247 GO:0045226 extracellular polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019878001 4150397 4152247 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019878001 4150397 4152247 GO:0045226 extracellular polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019878001 4150397 4152247 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + NADPH + H+. IEA GO:0008831 dTDP-4-dehydrorhamnose reductase activity GSVIVG01019878001 4150397 4152247 GO:0045226 extracellular polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. IEA Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + NADPH + H+. IEA GO:0008831 dTDP-4-dehydrorhamnose reductase activity GSVIVG01017315001 6657638 6658829 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01017315001 6657638 6658829 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01002961001 37441031 37441733 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01002961001 37441031 37441733 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01002961001 37441031 37441733 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022225001 17646224 17652373 GSVIVG01003865001 13025995 13026759 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01003865001 13025995 13026759 Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01012210001 544467 549815 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01012210001 544467 549815 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01012210001 544467 549815 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01012210001 544467 549815 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01027045001 18385250 18393574 GO:0019941 modification-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01027045001 18385250 18393574 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01027045001 18385250 18393574 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01027045001 18385250 18393574 GO:0019941 modification-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01027045001 18385250 18393574 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01027045001 18385250 18393574 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01005704001 21404649 21406950 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01005704001 21404649 21406950 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01005704001 21404649 21406950 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01005704001 21404649 21406950 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01004895001 16493682 16509936 GSVIVG01017073001 3967669 3972062 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01017073001 3967669 3972062 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01017073001 3967669 3972062 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01017073001 3967669 3972062 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01017073001 3967669 3972062 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01017073001 3967669 3972062 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01017073001 3967669 3972062 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01017073001 3967669 3972062 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01012640001 260075 262899 GSVIVG01008360001 2882630 2888851 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028448001 7772443 7777249 GSVIVG01020093001 10398334 10407828 GSVIVG01019711001 2634298 2636865 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019711001 2634298 2636865 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019711001 2634298 2636865 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019711001 2634298 2636865 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019711001 2634298 2636865 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01019711001 2634298 2636865 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01019711001 2634298 2636865 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01019711001 2634298 2636865 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01038775001 802777 803325 GSVIVG01002895001 37073064 37075521 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01002895001 37073064 37075521 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01002895001 37073064 37075521 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01002895001 37073064 37075521 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01011201001 9391005 9396194 GSVIVG01034416001 16590942 16597605 GO:0009231 riboflavin biosynthetic process The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). IEA Catalysis of the reaction: ATP + FMN = diphosphate + FAD. IEA GO:0003919 FMN adenylyltransferase activity GSVIVG01006675001 27383279 27387699 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01037487001 12859689 12868710 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020926001 17008194 17037290 GSVIVG01026625001 20929977 20930219 GSVIVG01037819001 7535043 7536583 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01027815001 8104351 8105282 GSVIVG01017532001 10032393 10036273 GSVIVG01007404001 31658154 31662068 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01007404001 31658154 31662068 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01037708001 7134473 7135460 GSVIVG01020308001 21600092 21602861 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with transfer RNA. IEA GO:0000049 tRNA binding GSVIVG01020308001 21600092 21602861 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with transfer RNA. IEA GO:0000049 tRNA binding GSVIVG01020308001 21600092 21602861 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01020308001 21600092 21602861 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01020308001 21600092 21602861 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe). IEA GO:0004826 phenylalanine-tRNA ligase activity GSVIVG01020308001 21600092 21602861 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe). IEA GO:0004826 phenylalanine-tRNA ligase activity GSVIVG01020308001 21600092 21602861 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020308001 21600092 21602861 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034970001 542606 545201 GSVIVG01019490001 1058659 1059355 GSVIVG01023379001 19179628 19183540 GSVIVG01021595001 7765400 7821944 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01021595001 7765400 7821944 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01021595001 7765400 7821944 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021595001 7765400 7821944 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021595001 7765400 7821944 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01021595001 7765400 7821944 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01021595001 7765400 7821944 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01021595001 7765400 7821944 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01021595001 7765400 7821944 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01021595001 7765400 7821944 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01037774001 7739874 7759142 GSVIVG01014205001 1451417 1452775 Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01019871001 4096658 4100463 GO:0006066 alcohol metabolic process The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GSVIVG01019871001 4096658 4100463 GO:0006066 alcohol metabolic process The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01006893001 28926352 28930111 GSVIVG01035088001 1377518 1379954 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion. IEA GO:0004806 triglyceride lipase activity GSVIVG01006576001 26580070 26584498 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01006576001 26580070 26584498 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01006576001 26580070 26584498 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01006576001 26580070 26584498 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01006576001 26580070 26584498 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01006576001 26580070 26584498 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01009547001 9265011 9267331 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA GSVIVG01009547001 9265011 9267331 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GSVIVG01012738001 1125949 1133842 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01012738001 1125949 1133842 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01012738001 1125949 1133842 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01012738001 1125949 1133842 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01024906001 6129232 6137393 GO:0006397 mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. IEA GSVIVG01017268001 6177367 6179654 GSVIVG01017740001 3051410 3053761 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0031461 cullin-RING ubiquitin ligase complex Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity. IEA Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins. IEA GO:0031625 ubiquitin protein ligase binding GSVIVG01002726001 36196538 36199819 GSVIVG01006542001 43071945 43072640 GSVIVG01037333001 15556361 15557670 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01037333001 15556361 15557670 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01032951001 24539183 24544952 GSVIVG01028799001 18685819 18687767 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023141001 22093388 22122373 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023141001 22093388 22122373 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023141001 22093388 22122373 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01023141001 22093388 22122373 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01018270001 12235112 12235735 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01018270001 12235112 12235735 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01018270001 12235112 12235735 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01018270001 12235112 12235735 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01018270001 12235112 12235735 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01018270001 12235112 12235735 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01032488001 27819928 27824490 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). IEA GO:0003755 peptidyl-prolyl cis-trans isomerase activity GSVIVG01020410001 19906333 19906912 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01020410001 19906333 19906912 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01027696001 14195762 14197891 GSVIVG01016130001 19533294 19533477 GSVIVG01018430001 15276901 15277651 GSVIVG01010306001 19233488 19241612 GSVIVG01030393001 5182942 5183355 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01022807001 16801817 16819506 GSVIVG01026948001 19165543 19171784 GSVIVG01015679001 15465128 15465860 GSVIVG01022626001 13681703 13716339 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01022626001 13681703 13716339 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029311001 17038389 17041543 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01008377001 2700966 2703196 GSVIVG01036499001 22695812 22698379 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01036499001 22695812 22698379 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01036499001 22695812 22698379 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01036499001 22695812 22698379 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01030254001 9841696 9842672 GSVIVG01015532001 4606994 4609819 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01015532001 4606994 4609819 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01007225001 30949366 30952046 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01007225001 30949366 30952046 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01007225001 30949366 30952046 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01007225001 30949366 30952046 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01000155001 15715343 15720091 Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01012037001 1959016 1964386 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor). IEA GO:0004659 prenyltransferase activity GSVIVG01031548001 17264678 17270676 GSVIVG01031151001 1687932 1691726 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01031151001 1687932 1691726 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01006690001 27563848 27567942 GSVIVG01003805001 296466 302656 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004185 serine-type carboxypeptidase activity GSVIVG01033870001 17128377 17132263 GSVIVG01026464001 23134466 23135818 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01012023001 2104057 2126179 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01012023001 2104057 2126179 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01014769001 9435391 9479675 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01014951001 12760340 12761747 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. IEA GO:0004364 glutathione transferase activity GSVIVG01011347001 28863610 28865569 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01000409001 7621709 7623155 GSVIVG01018015001 5493039 5501495 GSVIVG01032502001 27931599 27936505 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01032502001 27931599 27936505 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01017488001 9306258 9316461 GSVIVG01024337001 1141631 1148817 GSVIVG01034065001 15452978 15453577 GO:0006869 lipid transport The directed movement of lipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Interacting selectively and non-covalently with a lipid. IEA GO:0008289 lipid binding GSVIVG01027811001 8046845 8048416 GO:0009296 flagellum assembly The assembly of a flagellum. In bacteria, this is a whiplike motility appendage present on the surface of some species; in eukaryotes, flagella are threadlike protoplasmic extensions used to propel flagellates and sperm. Flagella are composed of flagellin and have the same basic structure as cilia but are longer in proportion to the cell and present in much smaller numbers. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01027811001 8046845 8048416 GO:0009296 flagellum assembly The assembly of a flagellum. In bacteria, this is a whiplike motility appendage present on the surface of some species; in eukaryotes, flagella are threadlike protoplasmic extensions used to propel flagellates and sperm. Flagella are composed of flagellin and have the same basic structure as cilia but are longer in proportion to the cell and present in much smaller numbers. IEA GO:0009424 bacterial-type flagellum hook The portion of the flagellum that connects the filament to the basal body. Examples of this component are found in bacteria. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01027811001 8046845 8048416 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01027811001 8046845 8048416 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0009424 bacterial-type flagellum hook The portion of the flagellum that connects the filament to the basal body. Examples of this component are found in bacteria. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01027811001 8046845 8048416 GO:0009296 flagellum assembly The assembly of a flagellum. In bacteria, this is a whiplike motility appendage present on the surface of some species; in eukaryotes, flagella are threadlike protoplasmic extensions used to propel flagellates and sperm. Flagella are composed of flagellin and have the same basic structure as cilia but are longer in proportion to the cell and present in much smaller numbers. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate. IEA GO:0003774 motor activity GSVIVG01027811001 8046845 8048416 GO:0009296 flagellum assembly The assembly of a flagellum. In bacteria, this is a whiplike motility appendage present on the surface of some species; in eukaryotes, flagella are threadlike protoplasmic extensions used to propel flagellates and sperm. Flagella are composed of flagellin and have the same basic structure as cilia but are longer in proportion to the cell and present in much smaller numbers. IEA GO:0009424 bacterial-type flagellum hook The portion of the flagellum that connects the filament to the basal body. Examples of this component are found in bacteria. IEA Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate. IEA GO:0003774 motor activity GSVIVG01027811001 8046845 8048416 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate. IEA GO:0003774 motor activity GSVIVG01027811001 8046845 8048416 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0009424 bacterial-type flagellum hook The portion of the flagellum that connects the filament to the basal body. Examples of this component are found in bacteria. IEA Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate. IEA GO:0003774 motor activity GSVIVG01025758001 12167580 12167729 GSVIVG01019052001 17331795 17344656 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01019052001 17331795 17344656 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01019052001 17331795 17344656 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with double-stranded RNA. IEA GO:0003725 double-stranded RNA binding GSVIVG01019052001 17331795 17344656 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01019052001 17331795 17344656 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt. IEA GO:0004525 ribonuclease III activity GSVIVG01019052001 17331795 17344656 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019052001 17331795 17344656 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01025494001 326465 331217 GSVIVG01001923001 14849414 14850223 GSVIVG01037973001 11911990 11918232 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GSVIVG01036538001 23160647 23194222 Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01036538001 23160647 23194222 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01036538001 23160647 23194222 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01034666001 7392665 7404192 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01017734001 3005063 3006659 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01021596001 7822500 7837762 GSVIVG01021248001 2942225 2949213 GSVIVG01015906001 19133601 19138570 GO:0006779 porphyrin biosynthetic process The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group. IEA Catalysis of the reaction: coproporphyrinogen-III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O. IEA GO:0004109 coproporphyrinogen oxidase activity GSVIVG01015906001 19133601 19138570 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: coproporphyrinogen-III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O. IEA GO:0004109 coproporphyrinogen oxidase activity GSVIVG01028554001 9667825 9668230 GSVIVG01015440001 3703265 3706829 GSVIVG01013374001 859574 862780 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01013374001 859574 862780 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01013374001 859574 862780 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01013374001 859574 862780 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032087001 22844948 22854718 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0005886 plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01032087001 22844948 22854718 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01027922001 9466482 9475315 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. IEA GO:0016836 hydro-lyase activity GSVIVG01027922001 9466482 9475315 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. IEA GO:0016836 hydro-lyase activity GSVIVG01027922001 9466482 9475315 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051539 4 iron, 4 sulfur cluster binding GSVIVG01027922001 9466482 9475315 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051539 4 iron, 4 sulfur cluster binding GSVIVG01016352001 4719898 4724111 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01016352001 4719898 4724111 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01024955001 5698385 5700076 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01015228001 1974266 1975451 Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01001291001 5078324 5098974 GO:0008202 steroid metabolic process The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. IEA GSVIVG01038056001 17116246 17118711 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01038056001 17116246 17118711 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01038056001 17116246 17118711 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01038056001 17116246 17118711 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01038056001 17116246 17118711 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038056001 17116246 17118711 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038056001 17116246 17118711 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01038056001 17116246 17118711 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01028052001 3456036 3458988 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01028052001 3456036 3458988 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01028052001 3456036 3458988 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01028052001 3456036 3458988 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01028052001 3456036 3458988 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01028052001 3456036 3458988 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01028052001 3456036 3458988 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01028052001 3456036 3458988 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01028052001 3456036 3458988 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01028052001 3456036 3458988 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01028052001 3456036 3458988 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01028052001 3456036 3458988 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01001149001 1283058 1289090 GSVIVG01034999001 795482 796805 GSVIVG01034048001 15589007 15594370 GSVIVG01032464001 27693164 27699967 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032464001 27693164 27699967 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA Catalysis of the reaction: protein serine/threonine/tyrosine phosphate + H2O = protein serine/threonine/tyrosine + phosphate. IEA GO:0008138 protein tyrosine/serine/threonine phosphatase activity GSVIVG01015298001 2478091 2481470 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01015298001 2478091 2481470 GO:0009405 pathogenesis The set of specific processes that generate the ability of an organism to cause disease in another. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01015298001 2478091 2481470 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01015298001 2478091 2481470 GO:0009405 pathogenesis The set of specific processes that generate the ability of an organism to cause disease in another. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01015298001 2478091 2481470 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01015298001 2478091 2481470 GO:0009405 pathogenesis The set of specific processes that generate the ability of an organism to cause disease in another. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01015298001 2478091 2481470 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01015298001 2478091 2481470 GO:0009405 pathogenesis The set of specific processes that generate the ability of an organism to cause disease in another. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01015298001 2478091 2481470 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015298001 2478091 2481470 GO:0009405 pathogenesis The set of specific processes that generate the ability of an organism to cause disease in another. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017329001 6764941 6765507 GSVIVG01001105001 22670468 22671235 GSVIVG01037906001 6447321 6451553 GSVIVG01018281001 12041523 12042599 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion. IEA GO:0004806 triglyceride lipase activity GSVIVG01026608001 21086940 21093820 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01006745001 28020508 28020792 GO:0006414 translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01006745001 28020508 28020792 GO:0006414 translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Functions in chain elongation during polypeptide synthesis at the ribosome. IEA GO:0003746 translation elongation factor activity GSVIVG01006745001 28020508 28020792 GO:0006414 translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01006745001 28020508 28020792 GO:0006414 translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01008394001 2544596 2556819 GO:0007031 peroxisome organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules. IEA GO:0005779 integral to peroxisomal membrane Penetrating at least one phospholipid bilayer of a peroxisomal membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA GSVIVG01027415001 16914720 16915042 GSVIVG01007419001 31693828 31697335 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009522 photosystem I A photosystem that contains an iron-sulfur reaction center associated with accessory pigments and electron carriers. In cyanobacteria and chloroplasts, photosystem I functions as a light-dependent plastocyanin-ferredoxin oxidoreductase, transferring electrons from plastocyanin to ferredoxin; in photosynthetic bacteria that have only a single type I photosystem, such as the green sulfur bacteria, electrons can go either to ferredoxin (Fd) -> NAD+ or to menaquinone (MK) -> Cytb/FeS -> Cytc555 -> photosystem I (cyclic photophosphorylation). IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01007419001 31693828 31697335 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009579 thylakoid A membranous cellular structure that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the plasma membrane. In eukaryotes they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01007419001 31693828 31697335 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01007419001 31693828 31697335 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009522 photosystem I A photosystem that contains an iron-sulfur reaction center associated with accessory pigments and electron carriers. In cyanobacteria and chloroplasts, photosystem I functions as a light-dependent plastocyanin-ferredoxin oxidoreductase, transferring electrons from plastocyanin to ferredoxin; in photosynthetic bacteria that have only a single type I photosystem, such as the green sulfur bacteria, electrons can go either to ferredoxin (Fd) -> NAD+ or to menaquinone (MK) -> Cytb/FeS -> Cytc555 -> photosystem I (cyclic photophosphorylation). IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01007419001 31693828 31697335 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009579 thylakoid A membranous cellular structure that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the plasma membrane. In eukaryotes they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01007419001 31693828 31697335 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01031656001 19643900 19662114 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01031656001 19643900 19662114 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01031656001 19643900 19662114 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01031656001 19643900 19662114 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. IEA GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GSVIVG01021789001 7408701 7410116 GSVIVG01003990001 26518120 26525131 GSVIVG01037448001 13571881 13574074 GSVIVG01004308001 38013082 38016891 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01004308001 38013082 38016891 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01022966001 17468688 17478991 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01022966001 17468688 17478991 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01007766001 9257910 9260120 GSVIVG01015136001 1306296 1310625 GSVIVG01020228001 8845182 8847044 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01020228001 8845182 8847044 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01020228001 8845182 8847044 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01020228001 8845182 8847044 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01020228001 8845182 8847044 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01020228001 8845182 8847044 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01020228001 8845182 8847044 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01020228001 8845182 8847044 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01016235001 6120577 6127926 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GSVIVG01018468001 14619669 14632502 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018468001 14619669 14632502 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: an alpha-L-fucoside + H2O = an alcohol + L-fucose. IEA GO:0004560 alpha-L-fucosidase activity GSVIVG01018468001 14619669 14632502 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01018314001 11210850 11216300 GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01018314001 11210850 11216300 GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01018314001 11210850 11216300 GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01012040001 1923583 1928032 GO:0006542 glutamine biosynthetic process The chemical reactions and pathways resulting in the formation of glutamine, 2-amino-4-carbamoylbutanoic acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012040001 1923583 1928032 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012040001 1923583 1928032 GO:0006542 glutamine biosynthetic process The chemical reactions and pathways resulting in the formation of glutamine, 2-amino-4-carbamoylbutanoic acid. IEA Catalysis of the reaction: ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine. IEA GO:0004356 glutamate-ammonia ligase activity GSVIVG01012040001 1923583 1928032 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA Catalysis of the reaction: ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine. IEA GO:0004356 glutamate-ammonia ligase activity GSVIVG01012040001 1923583 1928032 GO:0006542 glutamine biosynthetic process The chemical reactions and pathways resulting in the formation of glutamine, 2-amino-4-carbamoylbutanoic acid. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01012040001 1923583 1928032 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01022605001 5870886 5881803 GSVIVG01026567001 21691196 21691906 GSVIVG01020549001 4470302 4593022 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01020549001 4470302 4593022 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01020549001 4470302 4593022 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01020549001 4470302 4593022 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01035654001 3045208 3049485 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01035654001 3045208 3049485 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01016364001 4454553 4466574 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01016364001 4454553 4466574 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01016364001 4454553 4466574 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01016364001 4454553 4466574 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01016364001 4454553 4466574 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016364001 4454553 4466574 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016364001 4454553 4466574 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016364001 4454553 4466574 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01015108001 1103200 1103641 GSVIVG01021305001 3758667 3761920 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01021305001 3758667 3761920 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01007613001 11213165 11213993 GSVIVG01015103001 1081748 1088504 GSVIVG01020495001 18431718 18445331 GO:0006413 translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. IEA GO:0003743 translation initiation factor activity GSVIVG01020495001 18431718 18445331 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. IEA GO:0003743 translation initiation factor activity GSVIVG01020495001 18431718 18445331 GO:0006413 translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01020495001 18431718 18445331 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01020495001 18431718 18445331 GO:0006413 translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01020495001 18431718 18445331 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01035101001 1475051 1476875 GSVIVG01037618001 6281781 6288420 GSVIVG01014789001 9756610 9756822 GSVIVG01009771001 11153817 11161309 GSVIVG01010032001 13666500 13667021 GSVIVG01033395001 20978678 20984054 GSVIVG01033771001 17970818 17974036 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01033771001 17970818 17974036 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01033771001 17970818 17974036 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01033771001 17970818 17974036 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01018978001 18146217 18154487 GSVIVG01013934001 7011510 7025806 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01013934001 7011510 7025806 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01003918001 13598729 13614282 GSVIVG01032799001 667148 669859 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032799001 667148 669859 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01014228001 1682674 1684700 GSVIVG01005087001 14403658 14404557 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01005087001 14403658 14404557 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01005087001 14403658 14404557 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01021295001 3609601 3616001 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01021295001 3609601 3616001 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01021295001 3609601 3616001 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01021295001 3609601 3616001 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037730001 7308891 7311247 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01037696001 7005369 7014427 GSVIVG01024029001 1655926 1660436 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01024029001 1655926 1660436 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01024029001 1655926 1660436 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01024029001 1655926 1660436 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01024029001 1655926 1660436 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01024029001 1655926 1660436 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01024029001 1655926 1660436 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01024029001 1655926 1660436 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01024029001 1655926 1660436 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01024029001 1655926 1660436 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01024029001 1655926 1660436 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01024029001 1655926 1660436 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01024029001 1655926 1660436 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01024029001 1655926 1660436 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01024029001 1655926 1660436 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01024029001 1655926 1660436 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01024029001 1655926 1660436 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01024029001 1655926 1660436 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01024029001 1655926 1660436 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01024029001 1655926 1660436 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01024029001 1655926 1660436 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01024029001 1655926 1660436 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01024029001 1655926 1660436 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01024029001 1655926 1660436 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01024029001 1655926 1660436 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01024029001 1655926 1660436 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01024029001 1655926 1660436 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01024029001 1655926 1660436 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01024029001 1655926 1660436 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01024029001 1655926 1660436 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01024029001 1655926 1660436 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01024029001 1655926 1660436 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01024029001 1655926 1660436 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01024029001 1655926 1660436 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01024029001 1655926 1660436 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01024029001 1655926 1660436 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01024029001 1655926 1660436 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01024029001 1655926 1660436 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01024029001 1655926 1660436 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01024029001 1655926 1660436 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01001206001 812409 813674 GSVIVG01025393001 1126772 1130774 GSVIVG01007214001 30906448 30911807 GSVIVG01025363001 1452378 1460795 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01025363001 1452378 1460795 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017503001 9553796 9555134 GSVIVG01026799001 7436059 7436520 GSVIVG01016245001 5986256 5988020 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01016245001 5986256 5988020 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01016245001 5986256 5988020 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01016245001 5986256 5988020 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024444001 2627687 2630001 GSVIVG01023828001 3158672 3165038 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023828001 3158672 3165038 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023828001 3158672 3165038 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01023828001 3158672 3165038 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01017030001 3602105 3602945 Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01017030001 3602105 3602945 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01009464001 8591121 8596300 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01028624001 11037847 11040905 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01028624001 11037847 11040905 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01028624001 11037847 11040905 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028624001 11037847 11040905 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025192001 3524081 3528870 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01025192001 3524081 3528870 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with double-stranded RNA. IEA GO:0003725 double-stranded RNA binding GSVIVG01024841001 6511022 6511504 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of copper (Cu) ions from one side of a membrane to the other. IEA GO:0005375 copper ion transmembrane transporter activity GSVIVG01000913001 21855816 21861685 GO:0006006 glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000913001 21855816 21861685 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000913001 21855816 21861685 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000913001 21855816 21861685 GO:0006006 glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. IEA Catalysis of the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+. IEA GO:0004345 glucose-6-phosphate dehydrogenase activity GSVIVG01000913001 21855816 21861685 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+. IEA GO:0004345 glucose-6-phosphate dehydrogenase activity GSVIVG01000913001 21855816 21861685 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+. IEA GO:0004345 glucose-6-phosphate dehydrogenase activity GSVIVG01000913001 21855816 21861685 GO:0006006 glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01000913001 21855816 21861685 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01000913001 21855816 21861685 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01009973001 12959804 12961382 GSVIVG01010836001 23226432 23231766 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01010836001 23226432 23231766 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01010836001 23226432 23231766 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01034066001 15448792 15451303 GSVIVG01012532001 764935 779582 Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01012532001 764935 779582 Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01025674001 13029245 13030391 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025674001 13029245 13030391 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01036228001 8660502 8661017 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01036228001 8660502 8661017 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01036228001 8660502 8661017 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01036228001 8660502 8661017 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01036228001 8660502 8661017 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01036228001 8660502 8661017 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01007348001 31472471 31478294 GSVIVG01029306001 17162677 17211323 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of the terminal 1,2-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2). IEA GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity GSVIVG01029306001 17162677 17211323 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01018567001 13248425 13249431 GSVIVG01038496001 10401052 10403088 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1). IEA GO:0004326 tetrahydrofolylpolyglutamate synthase activity GSVIVG01038496001 10401052 10403088 GO:0009396 folic acid and derivative biosynthetic process The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. IEA Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1). IEA GO:0004326 tetrahydrofolylpolyglutamate synthase activity GSVIVG01038496001 10401052 10403088 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038496001 10401052 10403088 GO:0009396 folic acid and derivative biosynthetic process The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037501001 12602648 12637702 GO:0006777 Mo-molybdopterin cofactor biosynthetic process The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands. IEA GSVIVG01037501001 12602648 12637702 GO:0032324 molybdopterin cofactor biosynthetic process The chemical reactions and pathways resulting in the formation of the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands. IEA GSVIVG01031416001 18844462 18854463 GO:0009416 response to light stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01031416001 18844462 18854463 GO:0009416 response to light stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000957001 22268129 22269638 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031398001 19114967 19116074 GO:0008283 cell proliferation The multiplication or reproduction of cells, resulting in the expansion of a cell population. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation. IEA GO:0008083 growth factor activity GSVIVG01023190001 21341953 21342394 GSVIVG01011985001 2408594 2409466 GSVIVG01023493001 11046653 11047384 GSVIVG01021094001 1407191 1411378 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01021094001 1407191 1411378 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01021094001 1407191 1411378 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01008045001 6349780 6356685 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01008045001 6349780 6356685 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01035548001 2199114 2209197 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the repair of a photoproduct resulting from ultraviolet irradiation of two adjacent pyrimidine residues in DNA. IEA GO:0003913 DNA photolyase activity GSVIVG01030237001 10136637 10137839 GSVIVG01024526001 9213931 9215177 GSVIVG01019856001 3870913 3876274 GSVIVG01017243001 5848653 5862422 GSVIVG01008504001 1287130 1293354 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005773 vacuole A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol. IEA Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain. IEA GO:0004177 aminopeptidase activity GSVIVG01008504001 1287130 1293354 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005773 vacuole A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01015546001 4724229 4734710 GSVIVG01016389001 4296020 4299431 GSVIVG01021574001 7311440 7333864 GSVIVG01016099001 18966532 18972957 GSVIVG01036723001 23305998 23313302 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01033101001 25724366 25732603 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01033101001 25724366 25732603 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033101001 25724366 25732603 Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01033101001 25724366 25732603 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01032500001 27924807 27929085 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01032500001 27924807 27929085 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01032230001 13421231 13430258 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01032230001 13421231 13430258 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01032230001 13421231 13430258 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01032230001 13421231 13430258 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01021508001 6393805 6398173 GSVIVG01024455001 2789762 2793487 GSVIVG01029313001 17013430 17027108 GSVIVG01004034001 14367525 14369003 GSVIVG01026331001 14126029 14128649 GSVIVG01004791001 19318 78024 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01016403001 4195571 4196053 GSVIVG01008815001 2411697 2414689 GSVIVG01033827001 17416610 17426530 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01015138001 1318994 1321292 GO:0006559 L-phenylalanine catabolic process The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015138001 1318994 1321292 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015138001 1318994 1321292 GO:0006559 L-phenylalanine catabolic process The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of ammonia (NH3) to another substance via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. IEA GO:0016211 ammonia ligase activity GSVIVG01015138001 1318994 1321292 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of ammonia (NH3) to another substance via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. IEA GO:0016211 ammonia ligase activity GSVIVG01015138001 1318994 1321292 GO:0006559 L-phenylalanine catabolic process The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate. IEA GO:0016841 ammonia-lyase activity GSVIVG01015138001 1318994 1321292 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate. IEA GO:0016841 ammonia-lyase activity GSVIVG01035115001 1571671 1574165 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009976001 12980373 12985434 GSVIVG01029729001 13794483 13796015 GSVIVG01008502001 1305277 1307598 GO:0015886 heme transport The directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells. IEA GO:0015232 heme transporter activity GSVIVG01008502001 1305277 1307598 GO:0017004 cytochrome complex assembly The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells. IEA GO:0015232 heme transporter activity GSVIVG01016729001 696831 707867 GSVIVG01002069001 32659506 32661386 GSVIVG01035198001 10272951 10274688 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035198001 10272951 10274688 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01025076001 4750351 4751843 GSVIVG01009999001 13306083 13306887 GSVIVG01033845001 17291919 17297307 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033845001 17291919 17297307 GO:0048193 Golgi vesicle transport The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018918001 18658131 18658817 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01032030001 23354429 23358315 GO:0006779 porphyrin biosynthetic process The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01032030001 23354429 23358315 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01032030001 23354429 23358315 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01032030001 23354429 23358315 GO:0006779 porphyrin biosynthetic process The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01032030001 23354429 23358315 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01032030001 23354429 23358315 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01026949001 19142461 19145821 GSVIVG01033816001 17534684 17542341 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01033816001 17534684 17542341 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01033816001 17534684 17542341 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01033816001 17534684 17542341 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030504001 6270961 6272736 GO:0048268 clathrin coat assembly The process by which clathrin triskelia are assembled into the ordered structure known as a clathrin cage. IEA GO:0030118 clathrin coat A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes. IEA Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester. IEA GO:0005543 phospholipid binding GSVIVG01030504001 6270961 6272736 GO:0048268 clathrin coat assembly The process by which clathrin triskelia are assembled into the ordered structure known as a clathrin cage. IEA GO:0030118 clathrin coat A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes. IEA Interacting selectively and non-covalently with phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. IEA GO:0005545 phosphatidylinositol binding GSVIVG01030504001 6270961 6272736 GO:0048268 clathrin coat assembly The process by which clathrin triskelia are assembled into the ordered structure known as a clathrin cage. IEA GO:0030118 clathrin coat A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes. IEA Interacting selectively and non-covalently with a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles. IEA GO:0030276 clathrin binding GSVIVG01018295001 11616741 11623439 GSVIVG01009128001 5343384 5344522 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01022124001 16770342 16770854 GSVIVG01003111001 7327548 7337749 GSVIVG01002443001 774107 776036 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016651 oxidoreductase activity, acting on NADH or NADPH GSVIVG01022831001 18970312 18973696 GSVIVG01031236001 969017 981636 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01031236001 969017 981636 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01031236001 969017 981636 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01031236001 969017 981636 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01031236001 969017 981636 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01031236001 969017 981636 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01031236001 969017 981636 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031236001 969017 981636 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031236001 969017 981636 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01031236001 969017 981636 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01031236001 969017 981636 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01031236001 969017 981636 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01026508001 22463212 22468132 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026508001 22463212 22468132 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026508001 22463212 22468132 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026508001 22463212 22468132 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026508001 22463212 22468132 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01026508001 22463212 22468132 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01026508001 22463212 22468132 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01026508001 22463212 22468132 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025043001 5040417 5055157 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GSVIVG01031852001 4879760 4881735 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012264001 12643899 12646828 GSVIVG01029441001 22861803 22865787 GSVIVG01028521001 9111366 9118487 GSVIVG01022079001 16419520 16426416 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01022079001 16419520 16426416 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01022079001 16419520 16426416 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01010196001 17166277 17167723 GSVIVG01033651001 18918097 18921017 GO:0006730 one-carbon metabolic process The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. IEA Catalysis of the reaction: ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine. IEA GO:0004478 methionine adenosyltransferase activity GSVIVG01033651001 18918097 18921017 GO:0006730 one-carbon metabolic process The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000217001 16179866 16207211 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000217001 16179866 16207211 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000217001 16179866 16207211 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000217001 16179866 16207211 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000217001 16179866 16207211 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000217001 16179866 16207211 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000217001 16179866 16207211 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000217001 16179866 16207211 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000217001 16179866 16207211 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01000217001 16179866 16207211 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01000217001 16179866 16207211 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01000217001 16179866 16207211 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01000217001 16179866 16207211 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01000217001 16179866 16207211 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01000217001 16179866 16207211 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01000217001 16179866 16207211 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01000217001 16179866 16207211 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000217001 16179866 16207211 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000217001 16179866 16207211 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000217001 16179866 16207211 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000217001 16179866 16207211 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000217001 16179866 16207211 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000217001 16179866 16207211 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000217001 16179866 16207211 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000217001 16179866 16207211 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01000217001 16179866 16207211 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01000217001 16179866 16207211 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01000217001 16179866 16207211 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01000217001 16179866 16207211 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01000217001 16179866 16207211 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01000217001 16179866 16207211 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01000217001 16179866 16207211 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01000217001 16179866 16207211 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. IEA GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GSVIVG01000217001 16179866 16207211 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. IEA GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GSVIVG01000217001 16179866 16207211 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. IEA GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GSVIVG01000217001 16179866 16207211 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. IEA GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GSVIVG01000217001 16179866 16207211 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. IEA GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GSVIVG01000217001 16179866 16207211 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. IEA GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GSVIVG01000217001 16179866 16207211 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. IEA GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GSVIVG01000217001 16179866 16207211 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. IEA GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GSVIVG01000217001 16179866 16207211 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01000217001 16179866 16207211 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01000217001 16179866 16207211 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01000217001 16179866 16207211 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01000217001 16179866 16207211 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01000217001 16179866 16207211 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01000217001 16179866 16207211 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01000217001 16179866 16207211 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01000217001 16179866 16207211 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01000217001 16179866 16207211 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01000217001 16179866 16207211 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01000217001 16179866 16207211 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01000217001 16179866 16207211 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01000217001 16179866 16207211 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01000217001 16179866 16207211 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01000217001 16179866 16207211 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01000217001 16179866 16207211 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01000217001 16179866 16207211 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01000217001 16179866 16207211 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01000217001 16179866 16207211 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01000217001 16179866 16207211 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01000217001 16179866 16207211 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01000217001 16179866 16207211 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01000217001 16179866 16207211 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01032736001 1165257 1177838 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016431001 3992521 3994346 GSVIVG01016901001 2389675 2394833 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016901001 2389675 2394833 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016901001 2389675 2394833 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008237 metallopeptidase activity GSVIVG01016901001 2389675 2394833 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008237 metallopeptidase activity GSVIVG01016901001 2389675 2394833 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01016901001 2389675 2394833 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01016901001 2389675 2394833 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01016901001 2389675 2394833 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01015309001 2563204 2563828 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01015309001 2563204 2563828 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01009918001 12363304 12376914 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01009918001 12363304 12376914 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01018877001 19037259 19039810 GSVIVG01003817001 388481 391867 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01003817001 388481 391867 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01003817001 388481 391867 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01003817001 388481 391867 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01003817001 388481 391867 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003817001 388481 391867 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003817001 388481 391867 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01003817001 388481 391867 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01021972001 4884368 4918654 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01021972001 4884368 4918654 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01021972001 4884368 4918654 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01021972001 4884368 4918654 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01021972001 4884368 4918654 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01021972001 4884368 4918654 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01021972001 4884368 4918654 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01021972001 4884368 4918654 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01021972001 4884368 4918654 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01021972001 4884368 4918654 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01021972001 4884368 4918654 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01021972001 4884368 4918654 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01021972001 4884368 4918654 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01021972001 4884368 4918654 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01021972001 4884368 4918654 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01021972001 4884368 4918654 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01021972001 4884368 4918654 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01021972001 4884368 4918654 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01021972001 4884368 4918654 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01021972001 4884368 4918654 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01021972001 4884368 4918654 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01021972001 4884368 4918654 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01021972001 4884368 4918654 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01021972001 4884368 4918654 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01021972001 4884368 4918654 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01021972001 4884368 4918654 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01021972001 4884368 4918654 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01021972001 4884368 4918654 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01021972001 4884368 4918654 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01021972001 4884368 4918654 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01021972001 4884368 4918654 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01021972001 4884368 4918654 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01021972001 4884368 4918654 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01021972001 4884368 4918654 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01021972001 4884368 4918654 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01021972001 4884368 4918654 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01021972001 4884368 4918654 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01021972001 4884368 4918654 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01021972001 4884368 4918654 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01021972001 4884368 4918654 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01021972001 4884368 4918654 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01021972001 4884368 4918654 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01021972001 4884368 4918654 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01021972001 4884368 4918654 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01021972001 4884368 4918654 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01021972001 4884368 4918654 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01021972001 4884368 4918654 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01021972001 4884368 4918654 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01021972001 4884368 4918654 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01021972001 4884368 4918654 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01021972001 4884368 4918654 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01021972001 4884368 4918654 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01021972001 4884368 4918654 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01021972001 4884368 4918654 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01021972001 4884368 4918654 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01021972001 4884368 4918654 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01037348001 15367501 15369297 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the reaction: pectin + n H2O = n methanol + pectate. IEA GO:0030599 pectinesterase activity GSVIVG01021613001 8011192 8099774 GSVIVG01020899001 17575004 17582060 GSVIVG01024316001 779557 782583 GSVIVG01037394001 14421551 14429747 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01037394001 14421551 14429747 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01037394001 14421551 14429747 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01037394001 14421551 14429747 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01007906001 7701816 7708142 GSVIVG01022284001 18195546 18196879 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01022284001 18195546 18196879 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01014737001 9082908 9084983 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014737001 9082908 9084983 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01014737001 9082908 9084983 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01035984001 6805267 6813697 GSVIVG01027507001 16139534 16152051 GSVIVG01034141001 14881882 14882291 GSVIVG01015354001 2928897 2931119 GO:0009116 nucleoside metabolic process The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine). IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01004273001 37900904 37903579 GSVIVG01037383001 14647321 14652518 GSVIVG01005970001 23032843 23038985 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01010461001 20779156 20780679 GSVIVG01020819001 1579602 1603150 GSVIVG01020116001 10189900 10197800 GSVIVG01017120001 4373781 4377977 GSVIVG01019236001 2952168 2959635 GSVIVG01031067001 21772074 21780933 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031067001 21772074 21780933 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031067001 21772074 21780933 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031067001 21772074 21780933 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031067001 21772074 21780933 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01031067001 21772074 21780933 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01000300001 2643334 2645994 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01000300001 2643334 2645994 Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium. IEA GO:0005544 calcium-dependent phospholipid binding GSVIVG01008769001 1814394 1815552 GSVIVG01023263001 20443807 20444583 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin. IEA GO:0004221 ubiquitin thiolesterase activity GSVIVG01014856001 10675527 10680100 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01002960001 37439188 37439436 GSVIVG01037995001 12221269 12231244 GSVIVG01030365001 5031034 5031406 GSVIVG01009739001 10891149 10903368 GO:0006207 'de novo' pyrimidine base biosynthetic process The chemical reactions and pathways resulting in the formation of pyrimidine bases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors. IEA GO:0009348 ornithine carbamoyltransferase complex A homotrimeric protein complex that catalyzes the transfer of a carbamoyl group to ornithine, forming citrulline. IEA Catalysis of the reaction: carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. IEA GO:0004070 aspartate carbamoyltransferase activity GSVIVG01009739001 10891149 10903368 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA GO:0009348 ornithine carbamoyltransferase complex A homotrimeric protein complex that catalyzes the transfer of a carbamoyl group to ornithine, forming citrulline. IEA Catalysis of the reaction: carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. IEA GO:0004070 aspartate carbamoyltransferase activity GSVIVG01009739001 10891149 10903368 GO:0006207 'de novo' pyrimidine base biosynthetic process The chemical reactions and pathways resulting in the formation of pyrimidine bases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors. IEA GO:0009348 ornithine carbamoyltransferase complex A homotrimeric protein complex that catalyzes the transfer of a carbamoyl group to ornithine, forming citrulline. IEA Catalysis of the reaction: carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. IEA GO:0004585 ornithine carbamoyltransferase activity GSVIVG01009739001 10891149 10903368 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA GO:0009348 ornithine carbamoyltransferase complex A homotrimeric protein complex that catalyzes the transfer of a carbamoyl group to ornithine, forming citrulline. IEA Catalysis of the reaction: carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. IEA GO:0004585 ornithine carbamoyltransferase activity GSVIVG01009739001 10891149 10903368 GO:0006207 'de novo' pyrimidine base biosynthetic process The chemical reactions and pathways resulting in the formation of pyrimidine bases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors. IEA GO:0009348 ornithine carbamoyltransferase complex A homotrimeric protein complex that catalyzes the transfer of a carbamoyl group to ornithine, forming citrulline. IEA Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. IEA GO:0016597 amino acid binding GSVIVG01009739001 10891149 10903368 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA GO:0009348 ornithine carbamoyltransferase complex A homotrimeric protein complex that catalyzes the transfer of a carbamoyl group to ornithine, forming citrulline. IEA Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. IEA GO:0016597 amino acid binding GSVIVG01009739001 10891149 10903368 GO:0006207 'de novo' pyrimidine base biosynthetic process The chemical reactions and pathways resulting in the formation of pyrimidine bases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors. IEA GO:0009348 ornithine carbamoyltransferase complex A homotrimeric protein complex that catalyzes the transfer of a carbamoyl group to ornithine, forming citrulline. IEA Catalysis of the transfer of a carboxyl- or carbamoyl group from one compound (donor) to another (acceptor). IEA GO:0016743 carboxyl- or carbamoyltransferase activity GSVIVG01009739001 10891149 10903368 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA GO:0009348 ornithine carbamoyltransferase complex A homotrimeric protein complex that catalyzes the transfer of a carbamoyl group to ornithine, forming citrulline. IEA Catalysis of the transfer of a carboxyl- or carbamoyl group from one compound (donor) to another (acceptor). IEA GO:0016743 carboxyl- or carbamoyltransferase activity GSVIVG01012664001 422927 424655 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA GSVIVG01019422001 537380 544068 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016870001 2137500 2142359 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01010924001 15613334 15614090 GO:0009772 photosynthetic electron transport in photosystem II Electrons move from the primary electron acceptor (Quinone, Q) through a chain of electron transport molecules in the thylakoid membrane until they reach the ultimate electron acceptor of Photosystem II, which is plastocyanin (PC). The electron is then passed to the P700 chlorophyll a molecules of the reaction centre of photosystem I. IEA GO:0030077 plasma membrane light-harvesting complex A plasma membrane protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center. Examples of this complex are found in bacterial species. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01010924001 15613334 15614090 GO:0019684 photosynthesis, light reaction The light reactions of photosynthesis, which take place in photosystems II and I. Light energy is harvested and used to power the transfer of electrons among a series of electron donors and acceptors. The final electron acceptor is NADP+, which is reduced to NADPH. NADPH generated from light reactions is used in sugar synthesis in dark reactions. Light reactions also generate a proton motive force across the thylakoid membrane, and the proton gradient is used to synthesize ATP. There are two chemical reactions involved in the light reactions: water oxidation in photosystem II, and NADP reduction in photosystem I. IEA GO:0030077 plasma membrane light-harvesting complex A plasma membrane protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center. Examples of this complex are found in bacterial species. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01013395001 731592 736822 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01013395001 731592 736822 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027808001 7997776 7998800 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01035380001 896112 901069 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01035380001 896112 901069 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01035380001 896112 901069 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01035380001 896112 901069 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01035380001 896112 901069 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01035380001 896112 901069 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01035380001 896112 901069 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035380001 896112 901069 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035380001 896112 901069 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035380001 896112 901069 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035380001 896112 901069 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035380001 896112 901069 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01000534001 7323830 7327622 GO:0009416 response to light stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01000534001 7323830 7327622 GO:0009416 response to light stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01037447001 13590967 13595265 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018547001 13531881 13534050 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01018547001 13531881 13534050 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01018547001 13531881 13534050 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01018547001 13531881 13534050 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01018547001 13531881 13534050 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01018547001 13531881 13534050 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01032837001 360153 364048 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01032837001 360153 364048 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01032837001 360153 364048 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01032837001 360153 364048 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01031237001 964888 966717 GSVIVG01012480001 13694248 13718634 GSVIVG01027893001 9136221 9137303 GSVIVG01037405001 14279802 14282041 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01037405001 14279802 14282041 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01037405001 14279802 14282041 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01037405001 14279802 14282041 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01037405001 14279802 14282041 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01037405001 14279802 14282041 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01037405001 14279802 14282041 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01037405001 14279802 14282041 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01037405001 14279802 14282041 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01037405001 14279802 14282041 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01037405001 14279802 14282041 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01037405001 14279802 14282041 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01037405001 14279802 14282041 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01037405001 14279802 14282041 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01037405001 14279802 14282041 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01037405001 14279802 14282041 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01037405001 14279802 14282041 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01037405001 14279802 14282041 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01031917001 5357817 5367252 GO:0018279 protein amino acid N-linked glycosylation via asparagine The posttranslational glycosylation of protein via the N4 atom of peptidyl-asparagine forming N4-glycosyl-L-asparagine; the most common form is N-acetylglucosaminyl asparagine; N-acetylgalactosaminyl asparagine also occurs; this modification typically occurs in extracellular peptides with an N-X-(ST) motif. Partial modification has been observed to occur with cysteine, rather than serine or threonine, in the third position; secondary structure features are important, and proline in the second or fourth positions inhibits modification. IEA GO:0005789 endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum. IEA Catalysis of the reaction: dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by glycosylamine linkage to protein L-asparagine. IEA GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity GSVIVG01022245001 17794379 17797240 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01022245001 17794379 17797240 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01027944001 9849941 9851116 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01033462001 20474411 20493812 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01033462001 20474411 20493812 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001406001 18680237 18701933 GSVIVG01034506001 20203331 20206775 GSVIVG01038501001 10532681 10544446 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of the terminal 1,2-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2). IEA GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity GSVIVG01038501001 10532681 10544446 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01026968001 18943169 18947408 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain. IEA GO:0004177 aminopeptidase activity GSVIVG01022002001 4400403 4409663 GSVIVG01016876001 2169387 2178042 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016876001 2169387 2178042 GO:0046470 phosphatidylcholine metabolic process The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016876001 2169387 2178042 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate. IEA GO:0004630 phospholipase D activity GSVIVG01016876001 2169387 2178042 GO:0046470 phosphatidylcholine metabolic process The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate. IEA GO:0004630 phospholipase D activity GSVIVG01016876001 2169387 2178042 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01016876001 2169387 2178042 GO:0046470 phosphatidylcholine metabolic process The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01032589001 28608020 28613067 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01032589001 28608020 28613067 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032589001 28608020 28613067 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01034929001 179934 183907 GSVIVG01026066001 25040657 25045538 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01026066001 25040657 25045538 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01010142001 16268850 16269733 GSVIVG01011155001 7406578 7411658 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = D-myo-inositol 1,4,5-trisphosphate + diacylglycerol. IEA GO:0004435 phosphoinositide phospholipase C activity GSVIVG01011155001 7406578 7411658 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = D-myo-inositol 1,4,5-trisphosphate + diacylglycerol. IEA GO:0004435 phosphoinositide phospholipase C activity GSVIVG01011155001 7406578 7411658 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate. IEA GO:0004629 phospholipase C activity GSVIVG01011155001 7406578 7411658 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate. IEA GO:0004629 phospholipase C activity GSVIVG01011155001 7406578 7411658 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. IEA GO:0008081 phosphoric diester hydrolase activity GSVIVG01011155001 7406578 7411658 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. IEA GO:0008081 phosphoric diester hydrolase activity GSVIVG01025392001 1131392 1143140 GSVIVG01011417001 29512383 29513994 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01013676001 2423404 2464321 GO:0001522 pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01013676001 2423404 2464321 GO:0009451 RNA modification The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01013676001 2423404 2464321 GO:0001522 pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs. IEA Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. IEA GO:0009982 pseudouridine synthase activity GSVIVG01013676001 2423404 2464321 GO:0009451 RNA modification The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. IEA Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. IEA GO:0009982 pseudouridine synthase activity GSVIVG01001865001 274719 274919 GSVIVG01023695001 9436297 9438207 GSVIVG01022738001 15842217 15862400 GSVIVG01034583001 19072733 19073722 GSVIVG01027155001 17384811 17387631 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01027155001 17384811 17387631 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01027155001 17384811 17387631 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01027155001 17384811 17387631 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01027155001 17384811 17387631 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01027155001 17384811 17387631 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01027155001 17384811 17387631 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01027155001 17384811 17387631 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01027155001 17384811 17387631 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01027155001 17384811 17387631 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01027155001 17384811 17387631 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01027155001 17384811 17387631 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01027155001 17384811 17387631 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01027155001 17384811 17387631 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01027155001 17384811 17387631 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01027155001 17384811 17387631 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01027155001 17384811 17387631 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01027155001 17384811 17387631 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01018633001 11951387 11952442 GSVIVG01032913001 24058253 24074267 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01020490001 18546032 18549457 GSVIVG01025829001 11430916 11432159 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004197 cysteine-type endopeptidase activity GSVIVG01002897001 37095267 37096269 GSVIVG01035693001 3380180 3381794 GSVIVG01006670001 27350875 27352237 GSVIVG01024048001 1502133 1506352 GSVIVG01035507001 1879557 1888068 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01035507001 1879557 1888068 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01035507001 1879557 1888068 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035507001 1879557 1888068 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01008843001 2688559 2734484 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01008843001 2688559 2734484 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031382001 19323816 19328805 GSVIVG01020652001 3418260 3441785 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01020652001 3418260 3441785 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01010658001 15476652 15482836 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010658001 15476652 15482836 GO:0008299 isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010658001 15476652 15482836 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA. IEA GO:0004421 hydroxymethylglutaryl-CoA synthase activity GSVIVG01010658001 15476652 15482836 GO:0008299 isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. IEA Catalysis of the reaction: acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA. IEA GO:0004421 hydroxymethylglutaryl-CoA synthase activity GSVIVG01011087001 1694076 1706769 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01011087001 1694076 1706769 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01011087001 1694076 1706769 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01011087001 1694076 1706769 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01033600001 19413446 19416462 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01033600001 19413446 19416462 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026616001 20988399 20996526 GSVIVG01008639001 224846 230250 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01008639001 224846 230250 GO:0009725 response to hormone stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01008639001 224846 230250 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01008639001 224846 230250 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01008639001 224846 230250 GO:0009725 response to hormone stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01008639001 224846 230250 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01033595001 19448551 19457420 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01033595001 19448551 19457420 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01034407001 16755996 16758066 GSVIVG01035496001 1789849 1791252 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA GSVIVG01009899001 12252507 12257159 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: ATP + D-hexose = ADP + D-hexose 6-phosphate. IEA GO:0004396 hexokinase activity GSVIVG01009899001 12252507 12257159 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the reaction: ATP + D-hexose = ADP + D-hexose 6-phosphate. IEA GO:0004396 hexokinase activity GSVIVG01009899001 12252507 12257159 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009899001 12252507 12257159 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009899001 12252507 12257159 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01009899001 12252507 12257159 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01022507001 4126765 4169875 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01022507001 4126765 4169875 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022507001 4126765 4169875 Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01014465001 4110588 4155161 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin. IEA GO:0004221 ubiquitin thiolesterase activity GSVIVG01014465001 4110588 4155161 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01001975001 5931656 5931890 GSVIVG01029279001 17661520 17662288 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01029279001 17661520 17662288 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01029279001 17661520 17662288 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01029279001 17661520 17662288 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024097001 1082216 1096163 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01024097001 1082216 1096163 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01024097001 1082216 1096163 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024097001 1082216 1096163 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007238001 31016463 31020673 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01007238001 31016463 31020673 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01007238001 31016463 31020673 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007238001 31016463 31020673 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003170001 6009082 6020768 GSVIVG01036512001 22866035 22869527 GSVIVG01004881001 16366545 16371125 GSVIVG01008287001 3626431 3634245 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01008287001 3626431 3634245 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013765001 7791434 7798899 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01013765001 7791434 7798899 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01013765001 7791434 7798899 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01013765001 7791434 7798899 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01013765001 7791434 7798899 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01013765001 7791434 7798899 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01013765001 7791434 7798899 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01013765001 7791434 7798899 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01013765001 7791434 7798899 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate. IEA GO:0019001 guanyl nucleotide binding GSVIVG01013765001 7791434 7798899 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate. IEA GO:0019001 guanyl nucleotide binding GSVIVG01013765001 7791434 7798899 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate. IEA GO:0019001 guanyl nucleotide binding GSVIVG01013765001 7791434 7798899 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate. IEA GO:0019001 guanyl nucleotide binding GSVIVG01021055001 14513414 14516745 GO:0042773 ATP synthesis coupled electron transport The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP. IEA Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. IEA GO:0008137 NADH dehydrogenase (ubiquinone) activity GSVIVG01021055001 14513414 14516745 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. IEA GO:0008137 NADH dehydrogenase (ubiquinone) activity GSVIVG01000130001 15511393 15519710 GO:0009416 response to light stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01000130001 15511393 15519710 GO:0009416 response to light stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01026546001 21993962 21997860 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01026546001 21993962 21997860 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01026546001 21993962 21997860 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01026546001 21993962 21997860 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012211001 529830 543820 GSVIVG01033389001 21009932 21012901 GSVIVG01001097001 22621561 22626108 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01034768001 21159030 21160258 GSVIVG01023309001 19833800 19835145 GSVIVG01020744001 2411966 2415500 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01020744001 2411966 2415500 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01020744001 2411966 2415500 Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01029166001 18989167 18990551 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01029166001 18989167 18990551 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01029166001 18989167 18990551 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01029166001 18989167 18990551 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01029166001 18989167 18990551 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01029166001 18989167 18990551 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01029166001 18989167 18990551 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01029166001 18989167 18990551 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01001769001 2973167 2975275 GSVIVG01027983001 2965042 2991240 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01027983001 2965042 2991240 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027983001 2965042 2991240 Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01027983001 2965042 2991240 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01016062001 18173175 18224507 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027741001 7355480 7357179 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01027741001 7355480 7357179 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021390001 4824617 4845464 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01021390001 4824617 4845464 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01031920001 5411012 5414145 GO:0016481 negative regulation of transcription Any cellular process that stops, prevents or reduces the frequency, rate or extent of transcription. IEA Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0010181 FMN binding GSVIVG01031920001 5411012 5414145 GO:0016481 negative regulation of transcription Any cellular process that stops, prevents or reduces the frequency, rate or extent of transcription. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01038277001 24892329 24902319 Interacting selectively and non-covalently with transfer RNA. IEA GO:0000049 tRNA binding GSVIVG01011093001 1660668 1669267 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01011093001 1660668 1669267 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end. IEA GO:0004527 exonuclease activity GSVIVG01011093001 1660668 1669267 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01028968001 17013691 17015121 GSVIVG01032597001 28697418 28704721 GSVIVG01016914001 2507864 2508607 GSVIVG01031805001 4502406 4513315 GSVIVG01038703001 20826879 20828694 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01038703001 20826879 20828694 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01038703001 20826879 20828694 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01038703001 20826879 20828694 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003161001 6090644 6100274 GSVIVG01017411001 8105996 8107456 GSVIVG01021272001 3259643 3260370 GSVIVG01016827001 1736550 1737619 GSVIVG01022379001 19346491 19370130 GO:0000226 microtubule cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. IEA GO:0000922 spindle pole Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules. IEA GSVIVG01022379001 19346491 19370130 GO:0000226 microtubule cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. IEA GO:0005815 microtubule organizing center A cytoplasmic structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides. IEA GSVIVG01034094001 15189904 15193076 GSVIVG01013555001 20741174 20798303 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01013555001 20741174 20798303 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01013555001 20741174 20798303 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013555001 20741174 20798303 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01018620001 12134008 12136119 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the reaction: pectin + n H2O = n methanol + pectate. IEA GO:0030599 pectinesterase activity GSVIVG01001885001 6777252 6779398 GSVIVG01004876001 16296808 16298493 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GSVIVG01004635001 39247467 39248939 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01004635001 39247467 39248939 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01004635001 39247467 39248939 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01004635001 39247467 39248939 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01004635001 39247467 39248939 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01004635001 39247467 39248939 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01004635001 39247467 39248939 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01004635001 39247467 39248939 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01004635001 39247467 39248939 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008947001 3725280 3732386 GSVIVG01018844001 19369409 19372899 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01023049001 16368045 16368650 GSVIVG01014778001 9552236 9556795 GSVIVG01034823001 22181940 22182371 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01034823001 22181940 22182371 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024916001 6065153 6068846 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01011596001 6115017 6118768 GSVIVG01021296001 3624705 3629592 GSVIVG01009278001 6907055 6910618 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009278001 6907055 6910618 GO:0009081 branched chain family amino acid metabolic process The chemical reactions and pathways involving amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009278001 6907055 6910618 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: a branched-chain amino acid + 2-oxoglutarate = L-glutamate + a 2-oxocarboxylate derived from the branched-chain amino acid. Includes catalysis of the reaction: L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate and anaologous reactions involving L-isoleucine and L-valine. IEA GO:0004084 branched-chain-amino-acid transaminase activity GSVIVG01009278001 6907055 6910618 GO:0009081 branched chain family amino acid metabolic process The chemical reactions and pathways involving amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. IEA Catalysis of the reaction: a branched-chain amino acid + 2-oxoglutarate = L-glutamate + a 2-oxocarboxylate derived from the branched-chain amino acid. Includes catalysis of the reaction: L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate and anaologous reactions involving L-isoleucine and L-valine. IEA GO:0004084 branched-chain-amino-acid transaminase activity GSVIVG01001846001 26272582 26275994 GSVIVG01037944001 11294218 11296023 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008478001 1518274 1526623 GO:0006207 'de novo' pyrimidine base biosynthetic process The chemical reactions and pathways resulting in the formation of pyrimidine bases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008478001 1518274 1526623 GO:0006222 UMP biosynthetic process The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008478001 1518274 1526623 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008478001 1518274 1526623 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008478001 1518274 1526623 GO:0006207 'de novo' pyrimidine base biosynthetic process The chemical reactions and pathways resulting in the formation of pyrimidine bases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: (S)-dihydroorotate + acceptor = orotate + reduced acceptor. IEA GO:0004152 dihydroorotate dehydrogenase activity GSVIVG01008478001 1518274 1526623 GO:0006222 UMP biosynthetic process The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: (S)-dihydroorotate + acceptor = orotate + reduced acceptor. IEA GO:0004152 dihydroorotate dehydrogenase activity GSVIVG01008478001 1518274 1526623 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: (S)-dihydroorotate + acceptor = orotate + reduced acceptor. IEA GO:0004152 dihydroorotate dehydrogenase activity GSVIVG01008478001 1518274 1526623 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: (S)-dihydroorotate + acceptor = orotate + reduced acceptor. IEA GO:0004152 dihydroorotate dehydrogenase activity GSVIVG01008478001 1518274 1526623 GO:0006207 'de novo' pyrimidine base biosynthetic process The chemical reactions and pathways resulting in the formation of pyrimidine bases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: (S)-dihydroorotate + O2 = orotate + H2O2. IEA GO:0004158 dihydroorotate oxidase activity GSVIVG01008478001 1518274 1526623 GO:0006222 UMP biosynthetic process The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: (S)-dihydroorotate + O2 = orotate + H2O2. IEA GO:0004158 dihydroorotate oxidase activity GSVIVG01008478001 1518274 1526623 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: (S)-dihydroorotate + O2 = orotate + H2O2. IEA GO:0004158 dihydroorotate oxidase activity GSVIVG01008478001 1518274 1526623 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: (S)-dihydroorotate + O2 = orotate + H2O2. IEA GO:0004158 dihydroorotate oxidase activity GSVIVG01019684001 2435453 2439133 GSVIVG01018092001 6409647 6411676 GSVIVG01012047001 1819806 1823800 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA GSVIVG01037690001 6901741 6924736 GSVIVG01036417001 4867180 4867344 GSVIVG01019310001 1450785 1451685 GSVIVG01029895001 1051406 1059402 GSVIVG01014739001 9101591 9103718 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01014739001 9101591 9103718 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01014739001 9101591 9103718 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01013579001 21129969 21137218 GSVIVG01010759001 22332600 22335842 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01010759001 22332600 22335842 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01010759001 22332600 22335842 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019819001 3594087 3614388 GSVIVG01017820001 3724867 3754247 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01017820001 3724867 3754247 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01017820001 3724867 3754247 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01017820001 3724867 3754247 The action of a molecule that contributes to the structural integrity of a cell wall. IEA GO:0005199 structural constituent of cell wall GSVIVG01017820001 3724867 3754247 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017820001 3724867 3754247 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01020175001 9410542 9423702 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01020175001 9410542 9423702 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01020175001 9410542 9423702 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020175001 9410542 9423702 Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01026630001 20894725 20897159 GSVIVG01014467001 4163204 4172299 GSVIVG01025132001 4132852 4136070 GSVIVG01034324001 18119186 18119668 GSVIVG01032910001 24031909 24031947 GSVIVG01031275001 654659 656453 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005801 cis-Golgi network The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum. IEA GSVIVG01031275001 654659 656453 GO:0006888 ER to Golgi vesicle-mediated transport The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi. IEA GO:0005801 cis-Golgi network The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum. IEA GSVIVG01017041001 3709699 3713104 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01017041001 3709699 3713104 Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01017041001 3709699 3713104 Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051537 2 iron, 2 sulfur cluster binding GSVIVG01031150001 1693115 1707252 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GSVIVG01023660001 8646769 8697502 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01023660001 8646769 8697502 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01001221001 1435268 1437180 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01001221001 1435268 1437180 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01001221001 1435268 1437180 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01001221001 1435268 1437180 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001221001 1435268 1437180 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01001221001 1435268 1437180 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01009120001 5247449 5263653 GO:0006164 purine nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009120001 5247449 5263653 GO:0006164 purine nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. IEA Catalysis of the reaction: ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate. IEA GO:0004639 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity GSVIVG01009120001 5247449 5263653 GO:0006164 purine nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020853001 1081438 1092660 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01020853001 1081438 1092660 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01020853001 1081438 1092660 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01020853001 1081438 1092660 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026419001 23766045 23774373 GSVIVG01016369001 4405209 4405391 GSVIVG01021587001 7492680 7542978 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01020694001 3061019 3062117 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004197 cysteine-type endopeptidase activity GSVIVG01020694001 3061019 3062117 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01002650001 35640810 35641544 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01002650001 35640810 35641544 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01031784001 4335011 4339814 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01031784001 4335011 4339814 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01006991001 29604567 29606231 GSVIVG01014701001 8775197 8778689 GSVIVG01014347001 2856127 2858877 GSVIVG01035911001 5696451 5697730 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035911001 5696451 5697730 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01032182001 21774530 21775610 GSVIVG01004969001 17167474 17181186 GSVIVG01032247001 13791095 13795524 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01032247001 13791095 13795524 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034106001 15120036 15123481 GSVIVG01015330001 2752151 2755918 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01004521001 39004414 39010618 GO:0019028 viral capsid The protein coat that surrounds the infective nucleic acid in some virus particles. It comprises numerous regularly arranged subunits, or capsomeres. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01000819001 590406 594702 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01000819001 590406 594702 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000819001 590406 594702 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020450001 19222699 19224725 GSVIVG01032536001 28154711 28157332 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion. IEA GO:0004806 triglyceride lipase activity GSVIVG01032122001 22445528 22445719 GSVIVG01013517001 2108876 2110503 Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01013517001 2108876 2110503 Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01006654001 27256562 27264561 GSVIVG01014091001 289915 291185 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01014091001 289915 291185 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016939001 2778212 2782247 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01016939001 2778212 2782247 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01016939001 2778212 2782247 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01016939001 2778212 2782247 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016939001 2778212 2782247 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016762001 1135208 1137036 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016762001 1135208 1137036 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. IEA GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GSVIVG01009503001 8887800 8899263 GSVIVG01003417001 14809964 14812247 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01003417001 14809964 14812247 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01003417001 14809964 14812247 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01003417001 14809964 14812247 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01007921001 7520918 7524572 GSVIVG01007991001 6854110 6859764 GSVIVG01018107001 6611322 6615958 GSVIVG01006678001 27401085 27401810 GSVIVG01008430001 2150073 2152622 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01007168001 30623982 30627174 Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage. IEA GO:0016209 antioxidant activity GSVIVG01007168001 30623982 30627174 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01026444001 23597424 23600044 GO:0008299 isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+. IEA GO:0004420 hydroxymethylglutaryl-CoA reductase (NADPH) activity GSVIVG01026444001 23597424 23600044 GO:0015936 coenzyme A metabolic process The chemical reactions and pathways involving coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+. IEA GO:0004420 hydroxymethylglutaryl-CoA reductase (NADPH) activity GSVIVG01026444001 23597424 23600044 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+. IEA GO:0004420 hydroxymethylglutaryl-CoA reductase (NADPH) activity GSVIVG01026444001 23597424 23600044 GO:0008299 isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01026444001 23597424 23600044 GO:0015936 coenzyme A metabolic process The chemical reactions and pathways involving coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01026444001 23597424 23600044 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01026444001 23597424 23600044 GO:0008299 isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01026444001 23597424 23600044 GO:0015936 coenzyme A metabolic process The chemical reactions and pathways involving coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01026444001 23597424 23600044 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01026444001 23597424 23600044 GO:0008299 isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01026444001 23597424 23600044 GO:0015936 coenzyme A metabolic process The chemical reactions and pathways involving coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01026444001 23597424 23600044 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01022866001 18663943 18670736 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01022866001 18663943 18670736 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01022866001 18663943 18670736 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01022866001 18663943 18670736 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01022866001 18663943 18670736 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01022866001 18663943 18670736 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01026129001 12691489 12692838 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: a phenyl acetate + H2O = a phenol + acetate. IEA GO:0004064 arylesterase activity GSVIVG01026129001 12691489 12692838 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: 3-alpha(S)-strictosidine = tryptamine + secologanin. IEA GO:0016844 strictosidine synthase activity GSVIVG01021985001 4707840 4708564 GSVIVG01007789001 8992843 8998935 GO:0005992 trehalose biosynthetic process The chemical reactions and pathways resulting in the formation of trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007789001 8992843 8998935 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01004677001 39587845 39588544 GSVIVG01015769001 17241385 17241726 GSVIVG01022750001 16078748 16081536 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01027530001 15961898 15965010 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). IEA GO:0003755 peptidyl-prolyl cis-trans isomerase activity GSVIVG01020602001 3898345 3918407 GO:0042176 regulation of protein catabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0000502 proteasome complex A large multisubunit complex which catalyzes protein degradation. This complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01020602001 3898345 3918407 GO:0042176 regulation of protein catabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0000502 proteasome complex A large multisubunit complex which catalyzes protein degradation. This complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core. IEA Modulates the activity of an enzyme. IEA GO:0030234 enzyme regulator activity GSVIVG01016950001 2896541 2902446 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01016950001 2896541 2902446 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01013169001 7229353 7231070 GSVIVG01032350001 26577902 26578648 GSVIVG01019697001 2536049 2537782 GO:0006796 phosphate metabolic process The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01019697001 2536049 2537782 GO:0006796 phosphate metabolic process The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: diphosphate + H2O = 2 phosphate. IEA GO:0004427 inorganic diphosphatase activity GSVIVG01016449001 3792129 3800105 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01016449001 3792129 3800105 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01016449001 3792129 3800105 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01016449001 3792129 3800105 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01019257001 2474732 2478059 GSVIVG01024291001 589796 590371 GSVIVG01009853001 11789356 11791909 GSVIVG01033791001 17806832 17809801 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033791001 17806832 17809801 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033791001 17806832 17809801 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the reaction: D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate. IEA GO:0004332 fructose-bisphosphate aldolase activity GSVIVG01033791001 17806832 17809801 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate. IEA GO:0004332 fructose-bisphosphate aldolase activity GSVIVG01007545001 12376735 12378241 GO:0006779 porphyrin biosynthetic process The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007545001 12376735 12378241 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007545001 12376735 12378241 GO:0006779 porphyrin biosynthetic process The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: coproporphyrinogen-III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O. IEA GO:0004109 coproporphyrinogen oxidase activity GSVIVG01007545001 12376735 12378241 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: coproporphyrinogen-III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O. IEA GO:0004109 coproporphyrinogen oxidase activity GSVIVG01007545001 12376735 12378241 GO:0006779 porphyrin biosynthetic process The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01007545001 12376735 12378241 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01021084001 1305946 1307011 GSVIVG01021765001 10755760 10759820 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01021765001 10755760 10759820 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01002363001 34398180 34398717 GSVIVG01016675001 296820 302290 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA GSVIVG01023706001 9709849 9712090 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01023706001 9709849 9712090 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01023706001 9709849 9712090 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01023706001 9709849 9712090 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01023706001 9709849 9712090 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01023706001 9709849 9712090 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01023706001 9709849 9712090 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01023706001 9709849 9712090 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01023706001 9709849 9712090 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01023706001 9709849 9712090 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01023706001 9709849 9712090 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01023706001 9709849 9712090 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01023706001 9709849 9712090 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. IEA GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GSVIVG01023706001 9709849 9712090 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. IEA GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GSVIVG01023706001 9709849 9712090 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. IEA GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GSVIVG01023706001 9709849 9712090 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. IEA GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GSVIVG01023706001 9709849 9712090 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01023706001 9709849 9712090 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01023706001 9709849 9712090 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01023706001 9709849 9712090 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01031730001 3887067 3889560 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01031730001 3887067 3889560 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01031730001 3887067 3889560 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01031730001 3887067 3889560 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01009046001 4531169 4532914 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01035159001 12424525 12425265 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01035159001 12424525 12425265 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N2-methylguanine. IEA GO:0004809 tRNA (guanine-N2-)-methyltransferase activity GSVIVG01032524001 28075805 28077460 GSVIVG01027154001 17388602 17395277 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01027154001 17388602 17395277 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01027154001 17388602 17395277 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01027154001 17388602 17395277 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01027154001 17388602 17395277 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01027154001 17388602 17395277 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01027154001 17388602 17395277 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01027154001 17388602 17395277 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01027154001 17388602 17395277 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01027154001 17388602 17395277 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01027154001 17388602 17395277 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01027154001 17388602 17395277 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01027154001 17388602 17395277 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01027154001 17388602 17395277 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01027154001 17388602 17395277 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01027154001 17388602 17395277 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01027154001 17388602 17395277 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01027154001 17388602 17395277 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01010328001 19543650 19546789 GO:0006006 glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010328001 19543650 19546789 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010328001 19543650 19546789 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010328001 19543650 19546789 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010328001 19543650 19546789 GO:0006006 glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. IEA Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+. IEA GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity GSVIVG01010328001 19543650 19546789 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+. IEA GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity GSVIVG01010328001 19543650 19546789 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+. IEA GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity GSVIVG01010328001 19543650 19546789 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+. IEA GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity GSVIVG01010328001 19543650 19546789 GO:0006006 glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01010328001 19543650 19546789 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01010328001 19543650 19546789 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01010328001 19543650 19546789 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01010328001 19543650 19546789 GO:0006006 glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01010328001 19543650 19546789 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01010328001 19543650 19546789 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01010328001 19543650 19546789 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01010328001 19543650 19546789 GO:0006006 glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. IEA Catalysis of the reaction: glyceraldehyde 3-phosphate + (phosphate / H2O) + NAD(P)+ = (3-phospho-D-glyceroyl-phosphate / 3-phospho-D-glycerate) + NAD(P)H + H+. IEA GO:0008943 glyceraldehyde-3-phosphate dehydrogenase activity GSVIVG01010328001 19543650 19546789 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the reaction: glyceraldehyde 3-phosphate + (phosphate / H2O) + NAD(P)+ = (3-phospho-D-glyceroyl-phosphate / 3-phospho-D-glycerate) + NAD(P)H + H+. IEA GO:0008943 glyceraldehyde-3-phosphate dehydrogenase activity GSVIVG01010328001 19543650 19546789 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: glyceraldehyde 3-phosphate + (phosphate / H2O) + NAD(P)+ = (3-phospho-D-glyceroyl-phosphate / 3-phospho-D-glycerate) + NAD(P)H + H+. IEA GO:0008943 glyceraldehyde-3-phosphate dehydrogenase activity GSVIVG01010328001 19543650 19546789 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: glyceraldehyde 3-phosphate + (phosphate / H2O) + NAD(P)+ = (3-phospho-D-glyceroyl-phosphate / 3-phospho-D-glycerate) + NAD(P)H + H+. IEA GO:0008943 glyceraldehyde-3-phosphate dehydrogenase activity GSVIVG01010328001 19543650 19546789 GO:0006006 glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01010328001 19543650 19546789 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01010328001 19543650 19546789 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01010328001 19543650 19546789 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01000958001 22277021 22278198 GSVIVG01029568001 21434333 21438066 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Interacting selectively and non-covalently with damaged DNA. IEA GO:0003684 damaged DNA binding GSVIVG01029568001 21434333 21438066 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and primer. IEA GO:0003887 DNA-directed DNA polymerase activity GSVIVG01035615001 2735887 2742173 GSVIVG01031192001 1316448 1326327 GSVIVG01013773001 7718700 7722677 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GSVIVG01017188001 5168995 5182779 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01017188001 5168995 5182779 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01017188001 5168995 5182779 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017188001 5168995 5182779 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01017188001 5168995 5182779 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01007208001 30810903 30811308 GSVIVG01035466001 1479601 1482518 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01035466001 1479601 1482518 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01035466001 1479601 1482518 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01035466001 1479601 1482518 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01035466001 1479601 1482518 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01035466001 1479601 1482518 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01006035001 23344128 23348526 GO:0006414 translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Functions in chain elongation during polypeptide synthesis at the ribosome. IEA GO:0003746 translation elongation factor activity GSVIVG01006035001 23344128 23348526 GO:0006414 translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01006035001 23344128 23348526 GO:0006414 translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01015423001 3536280 3539365 GSVIVG01026828001 20133401 20140689 GSVIVG01015945001 16000783 16002740 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: ATP + glycerol = ADP + glycerol 3-phosphate. IEA GO:0004370 glycerol kinase activity GSVIVG01015945001 16000783 16002740 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA Catalysis of the reaction: ATP + glycerol = ADP + glycerol 3-phosphate. IEA GO:0004370 glycerol kinase activity GSVIVG01015945001 16000783 16002740 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01015945001 16000783 16002740 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01032900001 23939293 23945052 GSVIVG01001081001 22456617 22459058 GSVIVG01029990001 8739976 8744514 GSVIVG01023455001 11599164 11601842 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01035970001 6637506 6644647 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01032779001 817194 817709 GSVIVG01031216001 1112558 1113725 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031216001 1112558 1113725 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01033260001 22085871 22091707 GSVIVG01023344001 19503898 19514978 GO:0008219 cell death A biological process that results in permanent cessation of all vital functions of a cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01020097001 10377628 10383832 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01037259001 16829580 16854576 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01002801001 36541565 36544433 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01002801001 36541565 36544433 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01002801001 36541565 36544433 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01005373001 39901760 39905020 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01005373001 39901760 39905020 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01037265001 16743078 16743686 GSVIVG01015506001 4311188 4313270 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005875 microtubule associated complex Any multimeric complex connected to a microtubule. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01009355001 7650877 7691973 GSVIVG01028025001 3264290 3266394 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01010835001 23203330 23224286 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: reduced ETF + ubiquinone = ETF + ubiquinol. IEA GO:0004174 electron-transferring-flavoprotein dehydrogenase activity GSVIVG01010835001 23203330 23224286 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01032240001 13642646 13698080 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01007850001 8375783 8381026 GSVIVG01037644001 6497805 6501971 GSVIVG01037414001 14183083 14183349 GSVIVG01017805001 3594893 3606380 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01017805001 3594893 3606380 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01017805001 3594893 3606380 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01017805001 3594893 3606380 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009813001 11496356 11502830 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01009813001 11496356 11502830 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030126 COPI vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01009813001 11496356 11502830 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01009813001 11496356 11502830 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030126 COPI vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01009813001 11496356 11502830 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01009813001 11496356 11502830 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030126 COPI vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01009813001 11496356 11502830 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01009813001 11496356 11502830 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030126 COPI vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012577001 4082359 4084330 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01012577001 4082359 4084330 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01012577001 4082359 4084330 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01016221001 6368850 6379865 GO:0001522 pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01016221001 6368850 6379865 GO:0009451 RNA modification The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01016221001 6368850 6379865 GO:0001522 pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs. IEA Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. IEA GO:0009982 pseudouridine synthase activity GSVIVG01016221001 6368850 6379865 GO:0009451 RNA modification The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. IEA Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. IEA GO:0009982 pseudouridine synthase activity GSVIVG01016221001 6368850 6379865 GO:0001522 pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs. IEA Catalysis of the transfer of a functional group from one position to another within a single molecule. IEA GO:0016866 intramolecular transferase activity GSVIVG01016221001 6368850 6379865 GO:0009451 RNA modification The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. IEA Catalysis of the transfer of a functional group from one position to another within a single molecule. IEA GO:0016866 intramolecular transferase activity GSVIVG01022787001 16617284 16628864 GSVIVG01002064001 1288480 1293739 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GSVIVG01012547001 1132907 1140880 GSVIVG01021458001 5615971 5617564 GSVIVG01013023001 10045638 10047493 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01009604001 9804913 9814683 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01009604001 9804913 9814683 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01009604001 9804913 9814683 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01009604001 9804913 9814683 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01002382001 34510481 34511447 GSVIVG01024983001 5519372 5522858 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01024983001 5519372 5522858 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01020821001 1559949 1564931 GSVIVG01024111001 991431 993320 GSVIVG01010815001 22924189 22924772 Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01008259001 3952894 3954545 GSVIVG01034686001 7664442 7682387 GSVIVG01001931001 14945177 14952111 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01001931001 14945177 14952111 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01001931001 14945177 14952111 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01001931001 14945177 14952111 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01001931001 14945177 14952111 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000245001 20480522 20486303 GSVIVG01030044001 9089290 9097431 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01030044001 9089290 9097431 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01030044001 9089290 9097431 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01030044001 9089290 9097431 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014569001 5254957 5257674 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01014569001 5254957 5257674 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01023256001 20514908 20520033 GSVIVG01004735001 15649572 15649854 GSVIVG01005041001 17633457 17635724 GO:0009690 cytokinin metabolic process The chemical reactions and pathways involving cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01005041001 17633457 17635724 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01005041001 17633457 17635724 GO:0009690 cytokinin metabolic process The chemical reactions and pathways involving cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01005041001 17633457 17635724 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01005041001 17633457 17635724 GO:0009690 cytokinin metabolic process The chemical reactions and pathways involving cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators. IEA Catalysis of the reaction: N6-dimethylallyladenine + acceptor + H2O = adenine + 3-methylbut-2-enal + reduced electron acceptor. IEA GO:0019139 cytokinin dehydrogenase activity GSVIVG01005041001 17633457 17635724 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: N6-dimethylallyladenine + acceptor + H2O = adenine + 3-methylbut-2-enal + reduced electron acceptor. IEA GO:0019139 cytokinin dehydrogenase activity GSVIVG01005041001 17633457 17635724 GO:0009690 cytokinin metabolic process The chemical reactions and pathways involving cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01005041001 17633457 17635724 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01032283001 14521150 14526774 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01032283001 14521150 14526774 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01032283001 14521150 14526774 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01032283001 14521150 14526774 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01032283001 14521150 14526774 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01032283001 14521150 14526774 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01030104001 9886936 9893124 GSVIVG01025564001 14023739 14027677 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01025564001 14023739 14027677 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01025564001 14023739 14027677 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01025564001 14023739 14027677 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038719001 20625111 20637267 GSVIVG01038245001 24581724 24587377 Catalysis of the removal of a phosphate group from phosphorylated myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol. IEA GO:0004437 inositol or phosphatidylinositol phosphatase activity GSVIVG01016428001 4009232 4022575 GSVIVG01027600001 15139091 15146334 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027600001 15139091 15146334 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027600001 15139091 15146334 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027600001 15139091 15146334 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027600001 15139091 15146334 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01027600001 15139091 15146334 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01010959001 2646362 2646748 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01010959001 2646362 2646748 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01010959001 2646362 2646748 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01010959001 2646362 2646748 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01036958001 9538947 9552380 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01010049001 13833441 13835700 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010049001 13833441 13835700 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01027242001 17700390 17701439 GSVIVG01027098001 17968688 17972876 GSVIVG01018010001 5441227 5442341 GO:0006869 lipid transport The directed movement of lipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Interacting selectively and non-covalently with a lipid. IEA GO:0008289 lipid binding GSVIVG01012072001 1634734 1639729 GSVIVG01019121001 16561323 16562396 GSVIVG01031653001 19619815 19631614 GSVIVG01026500001 22535021 22554070 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026500001 22535021 22554070 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01020377001 20371244 20371540 GSVIVG01001263001 4821803 4823194 GSVIVG01037118001 28940632 28948447 GSVIVG01034707001 8138688 8141468 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019429001 621477 631791 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01019429001 621477 631791 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01019429001 621477 631791 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01019429001 621477 631791 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01019429001 621477 631791 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01019429001 621477 631791 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01019429001 621477 631791 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01019429001 621477 631791 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01019429001 621477 631791 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01019429001 621477 631791 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01019429001 621477 631791 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01019429001 621477 631791 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01019429001 621477 631791 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces an oxygen molecule. IEA GO:0050664 oxidoreductase activity, acting on NADH or NADPH, with oxygen as acceptor GSVIVG01019429001 621477 631791 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces an oxygen molecule. IEA GO:0050664 oxidoreductase activity, acting on NADH or NADPH, with oxygen as acceptor GSVIVG01010652001 15613072 15614615 GSVIVG01024065001 1402023 1405517 Catalysis of the transfer of the amide nitrogen of glutamine to a variety of substrates. GATases catalyze two separate reactions at two active sites, which are located either on a single polypeptide chain or on different subunits. In the glutaminase reaction, glutamine is hydrolyzed to glutamate and ammonia, which is added to an acceptor substrate in the synthase reaction. IEA GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor GSVIVG01035558001 2294135 2295171 GSVIVG01025830001 11427217 11429596 GSVIVG01022965001 17505598 17508679 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022965001 17505598 17508679 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015652001 14960609 14980498 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01038112001 23552620 23553650 GSVIVG01015778001 17392363 17399497 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01015778001 17392363 17399497 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009097001 5009692 5011145 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01020105001 10284072 10289573 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025727001 12569392 12611889 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the reaction: ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. IEA GO:0004618 phosphoglycerate kinase activity GSVIVG01025727001 12569392 12611889 GO:0006400 tRNA modification The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically. IEA Catalysis of the reaction: ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. IEA GO:0004618 phosphoglycerate kinase activity GSVIVG01025727001 12569392 12611889 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N7-methylguanine. IEA GO:0008176 tRNA (guanine-N7-)-methyltransferase activity GSVIVG01025727001 12569392 12611889 GO:0006400 tRNA modification The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically. IEA Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N7-methylguanine. IEA GO:0008176 tRNA (guanine-N7-)-methyltransferase activity GSVIVG01006222001 23746324 23748753 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016651 oxidoreductase activity, acting on NADH or NADPH GSVIVG01006222001 23746324 23748753 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds. IEA GO:0048038 quinone binding GSVIVG01006222001 23746324 23748753 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01023010001 16929679 16952508 GO:0009098 leucine biosynthetic process The chemical reactions and pathways resulting in the formation of leucine, 2-amino-4-methylpentanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01023010001 16929679 16952508 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01023010001 16929679 16952508 GO:0009098 leucine biosynthetic process The chemical reactions and pathways resulting in the formation of leucine, 2-amino-4-methylpentanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: 3-carboxy-2-hydroxy-4-methylpentanoate + NAD+ = 3-carboxy-4-methyl-2-oxopentanoate + NADH + H+. IEA GO:0003862 3-isopropylmalate dehydrogenase activity GSVIVG01023010001 16929679 16952508 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: 3-carboxy-2-hydroxy-4-methylpentanoate + NAD+ = 3-carboxy-4-methyl-2-oxopentanoate + NADH + H+. IEA GO:0003862 3-isopropylmalate dehydrogenase activity GSVIVG01023010001 16929679 16952508 GO:0009098 leucine biosynthetic process The chemical reactions and pathways resulting in the formation of leucine, 2-amino-4-methylpentanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01023010001 16929679 16952508 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01023010001 16929679 16952508 GO:0009098 leucine biosynthetic process The chemical reactions and pathways resulting in the formation of leucine, 2-amino-4-methylpentanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01023010001 16929679 16952508 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01009311001 7275007 7276547 GSVIVG01025995001 26155193 26155303 GSVIVG01025959001 26573497 26574595 GO:0006094 gluconeogenesis The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. IEA Catalysis of the reaction: D-glucose 6-phosphate = D-fructose 6-phosphate. IEA GO:0004347 glucose-6-phosphate isomerase activity GSVIVG01025959001 26573497 26574595 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the reaction: D-glucose 6-phosphate = D-fructose 6-phosphate. IEA GO:0004347 glucose-6-phosphate isomerase activity GSVIVG01018736001 20299415 20306280 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01018736001 20299415 20306280 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01018736001 20299415 20306280 GO:0007049 cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01018736001 20299415 20306280 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01018736001 20299415 20306280 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01018736001 20299415 20306280 GO:0007049 cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01011428001 29574045 29576921 GSVIVG01014679001 8497127 8523598 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01014679001 8497127 8523598 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01022161001 17139552 17141405 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01022161001 17139552 17141405 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). IEA GO:0016769 transferase activity, transferring nitrogenous groups GSVIVG01022161001 17139552 17141405 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01031834001 4770451 4771940 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01031834001 4770451 4771940 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01014770001 9479751 9482266 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01016411001 4157530 4160773 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01032995001 24948258 24949886 GSVIVG01025887001 27468331 27468644 GSVIVG01013760001 7871321 7875921 GSVIVG01014744001 9146520 9157750 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01008320001 3280283 3282567 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar. IEA GO:0008375 acetylglucosaminyltransferase activity GSVIVG01015741001 16670414 16670960 GSVIVG01038586001 21708615 21712122 GSVIVG01032609001 28800062 28801183 GSVIVG01011478001 29938292 29948353 GO:0009073 aromatic amino acid family biosynthetic process The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). IEA Catalysis of the reaction: chorismate = prephenate. IEA GO:0004106 chorismate mutase activity GSVIVG01011478001 29938292 29948353 GO:0046417 chorismate metabolic process The chemical reactions and pathways involving chorismate, the anion of (3R-trans)-3-((1-carboxyethenyl)oxy)-4-hydroxy-1,5-cyclohexadiene-1-carboxylic acid. IEA Catalysis of the reaction: chorismate = prephenate. IEA GO:0004106 chorismate mutase activity GSVIVG01022859001 18693374 18696351 GSVIVG01012167001 867583 888643 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01012167001 867583 888643 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01012167001 867583 888643 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01012167001 867583 888643 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01012167001 867583 888643 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012167001 867583 888643 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012167001 867583 888643 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012167001 867583 888643 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012167001 867583 888643 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012167001 867583 888643 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012167001 867583 888643 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012167001 867583 888643 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012167001 867583 888643 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01012167001 867583 888643 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01012167001 867583 888643 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01012167001 867583 888643 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01012484001 13733709 13735709 GSVIVG01012691001 674641 675257 GSVIVG01035214001 10642874 10646839 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01013894001 6273388 6275540 GSVIVG01033618001 19236350 19238185 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01033618001 19236350 19238185 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01023391001 12873272 12901917 GSVIVG01001340001 519278 521098 GSVIVG01036852001 18029532 18043172 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036852001 18029532 18043172 GO:0046488 phosphatidylinositol metabolic process The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036852001 18029532 18043172 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036852001 18029532 18043172 GO:0046488 phosphatidylinositol metabolic process The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036852001 18029532 18043172 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA Catalysis of the phosphorylation of phosphatidylinositol phosphate to produce phosphatidylinositol bisphosphate. IEA GO:0016307 phosphatidylinositol phosphate kinase activity GSVIVG01036852001 18029532 18043172 GO:0046488 phosphatidylinositol metabolic process The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. IEA Catalysis of the phosphorylation of phosphatidylinositol phosphate to produce phosphatidylinositol bisphosphate. IEA GO:0016307 phosphatidylinositol phosphate kinase activity GSVIVG01023356001 19392859 19393338 GSVIVG01016846001 1896062 1901939 GSVIVG01000649001 20396089 20409017 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0000139 Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01000649001 20396089 20409017 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01000649001 20396089 20409017 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01000649001 20396089 20409017 GO:0048280 vesicle fusion with Golgi apparatus The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the Golgi. IEA GO:0000139 Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01000649001 20396089 20409017 GO:0048280 vesicle fusion with Golgi apparatus The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the Golgi. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01000649001 20396089 20409017 GO:0048280 vesicle fusion with Golgi apparatus The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the Golgi. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01000649001 20396089 20409017 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0000139 Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01000649001 20396089 20409017 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01000649001 20396089 20409017 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01000649001 20396089 20409017 GO:0048280 vesicle fusion with Golgi apparatus The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the Golgi. IEA GO:0000139 Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01000649001 20396089 20409017 GO:0048280 vesicle fusion with Golgi apparatus The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the Golgi. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01000649001 20396089 20409017 GO:0048280 vesicle fusion with Golgi apparatus The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the Golgi. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01007430001 31825548 31830211 GSVIVG01014779001 9564244 9567519 GSVIVG01033872001 17107851 17116751 GSVIVG01024585001 8614284 8615839 GSVIVG01033749001 18144354 18146972 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01033749001 18144354 18146972 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01033749001 18144354 18146972 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01033749001 18144354 18146972 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033749001 18144354 18146972 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037563001 11254175 11257973 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01037563001 11254175 11257973 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01037563001 11254175 11257973 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01037563001 11254175 11257973 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01037563001 11254175 11257973 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019731001 2803900 2807681 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01014711001 8904732 8909949 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014711001 8904732 8909949 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014711001 8904732 8909949 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014711001 8904732 8909949 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009485001 8761894 8769250 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01009485001 8761894 8769250 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01009485001 8761894 8769250 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01009485001 8761894 8769250 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01033147001 8454240 8455121 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01033147001 8454240 8455121 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01033147001 8454240 8455121 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01021484001 6014811 6025241 GSVIVG01003778001 12551648 12556459 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01003778001 12551648 12556459 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01003778001 12551648 12556459 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01003778001 12551648 12556459 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026977001 18878378 18879040 GO:0009269 response to desiccation A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a desiccation stimulus, extreme dryness resulting from the prolonged deprivation of water. IEA GSVIVG01019552001 1560083 1563272 Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01011951001 2699662 2703084 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01011951001 2699662 2703084 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01011951001 2699662 2703084 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of potassium ions (K+) from one side of a membrane to the other. IEA GO:0015079 potassium ion transmembrane transporter activity GSVIVG01011951001 2699662 2703084 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of potassium ions (K+) from one side of a membrane to the other. IEA GO:0015079 potassium ion transmembrane transporter activity GSVIVG01032717001 1287625 1290989 GSVIVG01014690001 8672303 8673839 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01014690001 8672303 8673839 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01036334001 3899005 3913706 GSVIVG01014290001 2359668 2364324 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01014290001 2359668 2364324 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01014290001 2359668 2364324 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01014290001 2359668 2364324 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01020189001 9295369 9299506 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of arsenite from one side of a membrane to the other. IEA GO:0015105 arsenite transmembrane transporter activity GSVIVG01020189001 9295369 9299506 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of arsenite from one side of a membrane to the other. IEA GO:0015105 arsenite transmembrane transporter activity GSVIVG01036799001 22400680 22412010 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036799001 22400680 22412010 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036799001 22400680 22412010 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01036799001 22400680 22412010 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01029658001 12614143 12617453 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01006769001 28290681 28295479 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038260001 24763398 24776697 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01038260001 24763398 24776697 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01038260001 24763398 24776697 GO:0009089 lysine biosynthetic process via diaminopimelate The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01038260001 24763398 24776697 GO:0009089 lysine biosynthetic process via diaminopimelate The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01038260001 24763398 24776697 GO:0019877 diaminopimelate biosynthetic process The chemical reactions and pathways resulting in the formation of diaminopimelate, both as an intermediate in lysine biosynthesis and as a component (as meso-diaminopimelate) of the peptidoglycan of Gram-negative bacterial cell walls. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01038260001 24763398 24776697 GO:0019877 diaminopimelate biosynthetic process The chemical reactions and pathways resulting in the formation of diaminopimelate, both as an intermediate in lysine biosynthesis and as a component (as meso-diaminopimelate) of the peptidoglycan of Gram-negative bacterial cell walls. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01038260001 24763398 24776697 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01038260001 24763398 24776697 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01038260001 24763398 24776697 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme. IEA GO:0004867 serine-type endopeptidase inhibitor activity GSVIVG01038260001 24763398 24776697 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme. IEA GO:0004867 serine-type endopeptidase inhibitor activity GSVIVG01038260001 24763398 24776697 GO:0009089 lysine biosynthetic process via diaminopimelate The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme. IEA GO:0004867 serine-type endopeptidase inhibitor activity GSVIVG01038260001 24763398 24776697 GO:0009089 lysine biosynthetic process via diaminopimelate The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme. IEA GO:0004867 serine-type endopeptidase inhibitor activity GSVIVG01038260001 24763398 24776697 GO:0019877 diaminopimelate biosynthetic process The chemical reactions and pathways resulting in the formation of diaminopimelate, both as an intermediate in lysine biosynthesis and as a component (as meso-diaminopimelate) of the peptidoglycan of Gram-negative bacterial cell walls. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme. IEA GO:0004867 serine-type endopeptidase inhibitor activity GSVIVG01038260001 24763398 24776697 GO:0019877 diaminopimelate biosynthetic process The chemical reactions and pathways resulting in the formation of diaminopimelate, both as an intermediate in lysine biosynthesis and as a component (as meso-diaminopimelate) of the peptidoglycan of Gram-negative bacterial cell walls. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme. IEA GO:0004867 serine-type endopeptidase inhibitor activity GSVIVG01038260001 24763398 24776697 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme. IEA GO:0004867 serine-type endopeptidase inhibitor activity GSVIVG01038260001 24763398 24776697 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme. IEA GO:0004867 serine-type endopeptidase inhibitor activity GSVIVG01038260001 24763398 24776697 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01038260001 24763398 24776697 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01038260001 24763398 24776697 GO:0009089 lysine biosynthetic process via diaminopimelate The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01038260001 24763398 24776697 GO:0009089 lysine biosynthetic process via diaminopimelate The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01038260001 24763398 24776697 GO:0019877 diaminopimelate biosynthetic process The chemical reactions and pathways resulting in the formation of diaminopimelate, both as an intermediate in lysine biosynthesis and as a component (as meso-diaminopimelate) of the peptidoglycan of Gram-negative bacterial cell walls. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01038260001 24763398 24776697 GO:0019877 diaminopimelate biosynthetic process The chemical reactions and pathways resulting in the formation of diaminopimelate, both as an intermediate in lysine biosynthesis and as a component (as meso-diaminopimelate) of the peptidoglycan of Gram-negative bacterial cell walls. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01038260001 24763398 24776697 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01038260001 24763398 24776697 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01038260001 24763398 24776697 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: 2,3,4,5-tetrahydrodipicolinate + NADP+ = 2,3-dihydrodipicolinate + NADPH + H+. IEA GO:0008839 dihydrodipicolinate reductase activity GSVIVG01038260001 24763398 24776697 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of the reaction: 2,3,4,5-tetrahydrodipicolinate + NADP+ = 2,3-dihydrodipicolinate + NADPH + H+. IEA GO:0008839 dihydrodipicolinate reductase activity GSVIVG01038260001 24763398 24776697 GO:0009089 lysine biosynthetic process via diaminopimelate The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: 2,3,4,5-tetrahydrodipicolinate + NADP+ = 2,3-dihydrodipicolinate + NADPH + H+. IEA GO:0008839 dihydrodipicolinate reductase activity GSVIVG01038260001 24763398 24776697 GO:0009089 lysine biosynthetic process via diaminopimelate The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of the reaction: 2,3,4,5-tetrahydrodipicolinate + NADP+ = 2,3-dihydrodipicolinate + NADPH + H+. IEA GO:0008839 dihydrodipicolinate reductase activity GSVIVG01038260001 24763398 24776697 GO:0019877 diaminopimelate biosynthetic process The chemical reactions and pathways resulting in the formation of diaminopimelate, both as an intermediate in lysine biosynthesis and as a component (as meso-diaminopimelate) of the peptidoglycan of Gram-negative bacterial cell walls. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: 2,3,4,5-tetrahydrodipicolinate + NADP+ = 2,3-dihydrodipicolinate + NADPH + H+. IEA GO:0008839 dihydrodipicolinate reductase activity GSVIVG01038260001 24763398 24776697 GO:0019877 diaminopimelate biosynthetic process The chemical reactions and pathways resulting in the formation of diaminopimelate, both as an intermediate in lysine biosynthesis and as a component (as meso-diaminopimelate) of the peptidoglycan of Gram-negative bacterial cell walls. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of the reaction: 2,3,4,5-tetrahydrodipicolinate + NADP+ = 2,3-dihydrodipicolinate + NADPH + H+. IEA GO:0008839 dihydrodipicolinate reductase activity GSVIVG01038260001 24763398 24776697 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: 2,3,4,5-tetrahydrodipicolinate + NADP+ = 2,3-dihydrodipicolinate + NADPH + H+. IEA GO:0008839 dihydrodipicolinate reductase activity GSVIVG01038260001 24763398 24776697 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of the reaction: 2,3,4,5-tetrahydrodipicolinate + NADP+ = 2,3-dihydrodipicolinate + NADPH + H+. IEA GO:0008839 dihydrodipicolinate reductase activity GSVIVG01037337001 15510394 15514562 GSVIVG01036348001 4039510 4041809 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01036348001 4039510 4041809 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01031594001 18653164 18653382 GSVIVG01023007001 16995633 16997826 GSVIVG01012854001 6183108 6185989 GO:0001503 ossification The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance. IEA GSVIVG01012854001 6183108 6185989 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GSVIVG01033240001 22257828 22270781 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005643 nuclear pore Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined. IEA GSVIVG01005677001 21145008 21157646 GO:0016246 RNA interference The process by which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes. IEA GO:0016442 RNA-induced silencing complex A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01005677001 21145008 21157646 GO:0016246 RNA interference The process by which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes. IEA GO:0016442 RNA-induced silencing complex A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01005677001 21145008 21157646 GO:0016246 RNA interference The process by which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes. IEA GO:0016442 RNA-induced silencing complex A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01030630001 7302665 7305281 Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. IEA GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GSVIVG01031271001 666555 670555 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01017396001 7885352 7891252 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01026556001 21882921 21884724 GSVIVG01002273001 33827661 33830943 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01002273001 33827661 33830943 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01002273001 33827661 33830943 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01002273001 33827661 33830943 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01002273001 33827661 33830943 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01002273001 33827661 33830943 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01002273001 33827661 33830943 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01002273001 33827661 33830943 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01002273001 33827661 33830943 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01002273001 33827661 33830943 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01002273001 33827661 33830943 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01002273001 33827661 33830943 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01002273001 33827661 33830943 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01002273001 33827661 33830943 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01002273001 33827661 33830943 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01013583001 21184286 21193888 GSVIVG01031551001 17247089 17255991 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: ATP + D-hexose = ADP + D-hexose 6-phosphate. IEA GO:0004396 hexokinase activity GSVIVG01031551001 17247089 17255991 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the reaction: ATP + D-hexose = ADP + D-hexose 6-phosphate. IEA GO:0004396 hexokinase activity GSVIVG01031551001 17247089 17255991 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031551001 17247089 17255991 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031551001 17247089 17255991 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01031551001 17247089 17255991 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01022446001 3125009 3135478 GSVIVG01008529001 1078641 1079500 GSVIVG01032051001 23191363 23192223 GSVIVG01035359001 736445 742154 GSVIVG01021559001 7076836 7077964 GSVIVG01009939001 12634521 12635198 GSVIVG01015866001 18637510 18637809 GSVIVG01000590001 6748931 6767400 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000590001 6748931 6767400 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000590001 6748931 6767400 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000590001 6748931 6767400 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000590001 6748931 6767400 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01000590001 6748931 6767400 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01034078001 15343367 15348842 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01034078001 15343367 15348842 GO:0007596 blood coagulation The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01034078001 15343367 15348842 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01034078001 15343367 15348842 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01034078001 15343367 15348842 GO:0007596 blood coagulation The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01034078001 15343367 15348842 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01030434001 5528282 5529743 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01030434001 5528282 5529743 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01030434001 5528282 5529743 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030434001 5528282 5529743 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01011287001 10643907 10652343 GO:0008299 isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. IEA Catalysis of the reaction: ATP + (R)-5-diphosphomevalonate = ADP + phosphate + isopentenyl diphosphate + CO2. IEA GO:0004163 diphosphomevalonate decarboxylase activity GSVIVG01011287001 10643907 10652343 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA Catalysis of the reaction: ATP + (R)-5-diphosphomevalonate = ADP + phosphate + isopentenyl diphosphate + CO2. IEA GO:0004163 diphosphomevalonate decarboxylase activity GSVIVG01011287001 10643907 10652343 GO:0008299 isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011287001 10643907 10652343 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011287001 10643907 10652343 GO:0008299 isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01011287001 10643907 10652343 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01036945001 17133923 17139229 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01031409001 18992228 18993339 GSVIVG01003239001 8110192 8110486 GSVIVG01024473001 3070994 3077474 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01011613001 5978564 5979374 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01030087001 9724149 9725134 GSVIVG01026597001 21234508 21237843 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01025194001 3495322 3506098 GSVIVG01001791001 3240587 3241126 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016471 vacuolar proton-transporting V-type ATPase complex A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01009216001 6313166 6319284 GSVIVG01007843001 8454312 8456118 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01036735001 23190824 23190979 GSVIVG01015987001 16818405 16826052 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01015987001 16818405 16826052 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01006461001 26161101 26168598 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01006461001 26161101 26168598 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008506001 1274811 1279340 GSVIVG01022994001 17174191 17211504 GSVIVG01007779001 9117591 9119104 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01004310001 38020176 38021249 GSVIVG01011967001 2528440 2534313 GSVIVG01031141001 1785343 1796884 GO:0030036 actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. IEA GO:0008290 F-actin capping protein complex A heterodimer consisting of alpha and beta subunits that binds to and caps the barbed ends of actin filaments, thereby regulating the polymerization of actin monomers but not severing actin filaments. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01015013001 427493 442925 GSVIVG01014354001 2951995 2952975 GSVIVG01001834001 26186519 26191721 GO:0006233 dTDP biosynthetic process The chemical reactions and pathways resulting in the formation of dTDP, deoxyribosylthymine diphosphate (2'-deoxyribosylthymine5'-diphosphate). IEA Catalysis of the reaction: ATP + thymidine 5'-phosphate = ADP + thymidine 5'-diphosphate. IEA GO:0004798 thymidylate kinase activity GSVIVG01001834001 26186519 26191721 GO:0006233 dTDP biosynthetic process The chemical reactions and pathways resulting in the formation of dTDP, deoxyribosylthymine diphosphate (2'-deoxyribosylthymine5'-diphosphate). IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026479001 22934299 22945589 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01000102001 3541434 3542499 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with manganese (Mn) ions. IEA GO:0030145 manganese ion binding GSVIVG01000102001 3541434 3542499 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Functions in the storage of nutritious substrates. IEA GO:0045735 nutrient reservoir activity GSVIVG01033465001 20451648 20452502 GSVIVG01006792001 211981 234589 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01037278001 16531756 16539217 GSVIVG01036191001 9273608 9280327 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036191001 9273608 9280327 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036191001 9273608 9280327 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036191001 9273608 9280327 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009000001 4156749 4159157 GSVIVG01026707001 5227757 5230955 Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01023983001 1929876 1930536 GSVIVG01015111001 1112462 1116155 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01015111001 1112462 1116155 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01000729001 230407 236329 GO:0006749 glutathione metabolic process The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+. IEA GO:0004362 glutathione-disulfide reductase activity GSVIVG01000729001 230407 236329 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+. IEA GO:0004362 glutathione-disulfide reductase activity GSVIVG01000729001 230407 236329 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+. IEA GO:0004362 glutathione-disulfide reductase activity GSVIVG01000729001 230407 236329 GO:0006749 glutathione metabolic process The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01000729001 230407 236329 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01000729001 230407 236329 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01000729001 230407 236329 GO:0006749 glutathione metabolic process The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01000729001 230407 236329 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01000729001 230407 236329 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01000729001 230407 236329 GO:0006749 glutathione metabolic process The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01000729001 230407 236329 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01000729001 230407 236329 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01013761001 7860802 7871133 GO:0015937 coenzyme A biosynthetic process The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. IEA Catalysis of the reaction: ATP + pantothenate = ADP + D-4'-phosphopantothenate. IEA GO:0004594 pantothenate kinase activity GSVIVG01013761001 7860802 7871133 GO:0015937 coenzyme A biosynthetic process The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026137001 12756583 12763527 GO:0006801 superoxide metabolic process The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species. IEA Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + H2O2. IEA GO:0004784 superoxide dismutase activity GSVIVG01026137001 12756583 12763527 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + H2O2. IEA GO:0004784 superoxide dismutase activity GSVIVG01026137001 12756583 12763527 GO:0006801 superoxide metabolic process The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01026137001 12756583 12763527 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01025780001 11941530 11942537 GSVIVG01001005001 11335786 11337793 GSVIVG01026075001 24924817 24927056 GSVIVG01019183001 3854845 3856891 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01019183001 3854845 3856891 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01019183001 3854845 3856891 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01019183001 3854845 3856891 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01019183001 3854845 3856891 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01019183001 3854845 3856891 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01033801001 17680546 17724664 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033801001 17680546 17724664 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01033801001 17680546 17724664 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01007285001 31291468 31297951 GSVIVG01034545001 19625488 19626211 GSVIVG01033000001 24986266 24988490 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01033000001 24986266 24988490 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01033000001 24986266 24988490 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033000001 24986266 24988490 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01033000001 24986266 24988490 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01024707001 7599649 7605419 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain. IEA GO:0004177 aminopeptidase activity GSVIVG01024707001 7599649 7605419 GO:0009987 cellular process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. IEA Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain. IEA GO:0004177 aminopeptidase activity GSVIVG01024707001 7599649 7605419 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008235 metalloexopeptidase activity GSVIVG01024707001 7599649 7605419 GO:0009987 cellular process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008235 metalloexopeptidase activity GSVIVG01008125001 5578565 5580163 GSVIVG01008251001 4079992 4081808 GSVIVG01027463001 16539622 16542157 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01027463001 16539622 16542157 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01023809001 3308724 3310004 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01016957001 2964441 2971831 Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum. IEA GO:0003993 acid phosphatase activity GSVIVG01035837001 4774937 4776688 GSVIVG01008239001 4233000 4244972 GSVIVG01009484001 8755459 8760697 GSVIVG01009982001 13043156 13050653 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01009982001 13043156 13050653 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01025216001 3161654 3220364 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01025216001 3161654 3220364 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01025216001 3161654 3220364 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01025216001 3161654 3220364 GO:0009405 pathogenesis The set of specific processes that generate the ability of an organism to cause disease in another. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01025216001 3161654 3220364 GO:0009405 pathogenesis The set of specific processes that generate the ability of an organism to cause disease in another. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01025216001 3161654 3220364 GO:0009405 pathogenesis The set of specific processes that generate the ability of an organism to cause disease in another. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01025216001 3161654 3220364 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025216001 3161654 3220364 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025216001 3161654 3220364 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025216001 3161654 3220364 GO:0009405 pathogenesis The set of specific processes that generate the ability of an organism to cause disease in another. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025216001 3161654 3220364 GO:0009405 pathogenesis The set of specific processes that generate the ability of an organism to cause disease in another. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025216001 3161654 3220364 GO:0009405 pathogenesis The set of specific processes that generate the ability of an organism to cause disease in another. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025216001 3161654 3220364 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Interacting selectively and non-covalently with chromatin, the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase. IEA GO:0003682 chromatin binding GSVIVG01025216001 3161654 3220364 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with chromatin, the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase. IEA GO:0003682 chromatin binding GSVIVG01025216001 3161654 3220364 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with chromatin, the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase. IEA GO:0003682 chromatin binding GSVIVG01025216001 3161654 3220364 GO:0009405 pathogenesis The set of specific processes that generate the ability of an organism to cause disease in another. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Interacting selectively and non-covalently with chromatin, the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase. IEA GO:0003682 chromatin binding GSVIVG01025216001 3161654 3220364 GO:0009405 pathogenesis The set of specific processes that generate the ability of an organism to cause disease in another. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with chromatin, the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase. IEA GO:0003682 chromatin binding GSVIVG01025216001 3161654 3220364 GO:0009405 pathogenesis The set of specific processes that generate the ability of an organism to cause disease in another. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with chromatin, the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase. IEA GO:0003682 chromatin binding GSVIVG01025216001 3161654 3220364 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01025216001 3161654 3220364 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01025216001 3161654 3220364 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01025216001 3161654 3220364 GO:0009405 pathogenesis The set of specific processes that generate the ability of an organism to cause disease in another. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01025216001 3161654 3220364 GO:0009405 pathogenesis The set of specific processes that generate the ability of an organism to cause disease in another. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01025216001 3161654 3220364 GO:0009405 pathogenesis The set of specific processes that generate the ability of an organism to cause disease in another. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01025216001 3161654 3220364 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025216001 3161654 3220364 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025216001 3161654 3220364 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025216001 3161654 3220364 GO:0009405 pathogenesis The set of specific processes that generate the ability of an organism to cause disease in another. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025216001 3161654 3220364 GO:0009405 pathogenesis The set of specific processes that generate the ability of an organism to cause disease in another. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025216001 3161654 3220364 GO:0009405 pathogenesis The set of specific processes that generate the ability of an organism to cause disease in another. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025216001 3161654 3220364 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025216001 3161654 3220364 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025216001 3161654 3220364 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025216001 3161654 3220364 GO:0009405 pathogenesis The set of specific processes that generate the ability of an organism to cause disease in another. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025216001 3161654 3220364 GO:0009405 pathogenesis The set of specific processes that generate the ability of an organism to cause disease in another. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025216001 3161654 3220364 GO:0009405 pathogenesis The set of specific processes that generate the ability of an organism to cause disease in another. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025216001 3161654 3220364 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01025216001 3161654 3220364 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01025216001 3161654 3220364 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01025216001 3161654 3220364 GO:0009405 pathogenesis The set of specific processes that generate the ability of an organism to cause disease in another. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01025216001 3161654 3220364 GO:0009405 pathogenesis The set of specific processes that generate the ability of an organism to cause disease in another. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01025216001 3161654 3220364 GO:0009405 pathogenesis The set of specific processes that generate the ability of an organism to cause disease in another. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01038675001 21066286 21076136 GO:0006298 mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. IEA Interacting selectively and non-covalently with damaged DNA. IEA GO:0003684 damaged DNA binding GSVIVG01038675001 21066286 21076136 GO:0045005 maintenance of fidelity involved in DNA-dependent DNA replication A DNA metabolic process that prevents or corrects errors to ensure that DNA is replicated accurately. Errors can be corrected either by intrinsic DNA polymerase proofreading activity or via mismatch repair. IEA Interacting selectively and non-covalently with damaged DNA. IEA GO:0003684 damaged DNA binding GSVIVG01038675001 21066286 21076136 GO:0006298 mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038675001 21066286 21076136 GO:0045005 maintenance of fidelity involved in DNA-dependent DNA replication A DNA metabolic process that prevents or corrects errors to ensure that DNA is replicated accurately. Errors can be corrected either by intrinsic DNA polymerase proofreading activity or via mismatch repair. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038675001 21066286 21076136 GO:0006298 mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. IEA Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches. IEA GO:0030983 mismatched DNA binding GSVIVG01038675001 21066286 21076136 GO:0045005 maintenance of fidelity involved in DNA-dependent DNA replication A DNA metabolic process that prevents or corrects errors to ensure that DNA is replicated accurately. Errors can be corrected either by intrinsic DNA polymerase proofreading activity or via mismatch repair. IEA Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches. IEA GO:0030983 mismatched DNA binding GSVIVG01014875001 11033381 11033557 GSVIVG01010599001 16163504 16171880 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01010599001 16163504 16171880 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01027320001 16616800 16624078 GSVIVG01035810001 4553793 4556216 GSVIVG01020402001 20024722 20025572 GSVIVG01031882001 5125033 5126676 GSVIVG01016718001 605033 613897 GSVIVG01037156001 28508788 28511552 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01028848001 18108245 18110229 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01006537001 43031432 43032732 GSVIVG01008225001 4493028 4493183 GSVIVG01010703001 12071590 12092702 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01010703001 12071590 12092702 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01010703001 12071590 12092702 GO:0006438 valyl-tRNA aminoacylation The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01010703001 12071590 12092702 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01010703001 12071590 12092702 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01010703001 12071590 12092702 GO:0006438 valyl-tRNA aminoacylation The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01010703001 12071590 12092702 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val). IEA GO:0004832 valine-tRNA ligase activity GSVIVG01010703001 12071590 12092702 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val). IEA GO:0004832 valine-tRNA ligase activity GSVIVG01010703001 12071590 12092702 GO:0006438 valyl-tRNA aminoacylation The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val). IEA GO:0004832 valine-tRNA ligase activity GSVIVG01010703001 12071590 12092702 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010703001 12071590 12092702 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010703001 12071590 12092702 GO:0006438 valyl-tRNA aminoacylation The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027769001 7527982 7529676 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01027769001 7527982 7529676 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01035377001 880518 883852 GSVIVG01033998001 16008818 16016833 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GSVIVG01020340001 21080849 21081472 GSVIVG01025889001 27461823 27467042 GSVIVG01032130001 22377535 22378658 GSVIVG01012863001 6332006 6333370 GSVIVG01032568001 28424055 28454905 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031446001 18422781 18423262 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01021986001 4698477 4706883 GSVIVG01011887001 3281771 3283983 GSVIVG01009260001 6771378 6774993 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01009260001 6771378 6774993 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01029564001 21507464 21510993 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004197 cysteine-type endopeptidase activity GSVIVG01029564001 21507464 21510993 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004197 cysteine-type endopeptidase activity GSVIVG01029564001 21507464 21510993 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta-adrenergic receptors; the activity involves transmitting the signal to the Gs alpha subunit of a heterotrimeric G protein. IEA GO:0004939 beta-adrenergic receptor activity GSVIVG01029564001 21507464 21510993 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta-adrenergic receptors; the activity involves transmitting the signal to the Gs alpha subunit of a heterotrimeric G protein. IEA GO:0004939 beta-adrenergic receptor activity GSVIVG01028952001 17139144 17139784 GSVIVG01014656001 8237667 8239566 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01014656001 8237667 8239566 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01037722001 7248621 7255469 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GSVIVG01037722001 7248621 7255469 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GSVIVG01009444001 8418530 8422383 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01009444001 8418530 8422383 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01009444001 8418530 8422383 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01009444001 8418530 8422383 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01009444001 8418530 8422383 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036053001 21340808 21342747 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01006470001 26252369 26255385 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01006470001 26252369 26255385 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01006470001 26252369 26255385 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01006470001 26252369 26255385 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01006470001 26252369 26255385 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01006470001 26252369 26255385 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01006470001 26252369 26255385 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01006470001 26252369 26255385 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01006470001 26252369 26255385 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01006470001 26252369 26255385 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01006470001 26252369 26255385 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01006470001 26252369 26255385 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01006470001 26252369 26255385 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01006470001 26252369 26255385 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01006470001 26252369 26255385 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01006470001 26252369 26255385 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01006470001 26252369 26255385 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01006470001 26252369 26255385 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01006470001 26252369 26255385 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01006470001 26252369 26255385 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01006470001 26252369 26255385 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01006470001 26252369 26255385 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01006470001 26252369 26255385 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01006470001 26252369 26255385 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01006470001 26252369 26255385 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01006470001 26252369 26255385 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01006470001 26252369 26255385 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01025018001 5232848 5237833 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01023404001 12462959 12469692 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023404001 12462959 12469692 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023404001 12462959 12469692 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023404001 12462959 12469692 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023404001 12462959 12469692 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023404001 12462959 12469692 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023404001 12462959 12469692 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01023404001 12462959 12469692 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01015296001 2466645 2467095 GSVIVG01028685001 12053580 12072090 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01034060001 15484860 15486038 GSVIVG01002032001 32404149 32405559 GSVIVG01038247001 24593709 24597879 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether. IEA GO:0008119 thiopurine S-methyltransferase activity GSVIVG01029748001 14103616 14106189 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01029748001 14103616 14106189 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01029748001 14103616 14106189 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01029748001 14103616 14106189 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01035542001 2152967 2153436 GSVIVG01020590001 3973680 3978140 GSVIVG01015702001 15885628 15890499 GSVIVG01024037001 1570599 1575263 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005839 proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. IEA GO:0004175 endopeptidase activity GSVIVG01024037001 1570599 1575263 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0019773 proteasome core complex, alpha-subunit complex The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. IEA GO:0004175 endopeptidase activity GSVIVG01024037001 1570599 1575263 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0005839 proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. IEA GO:0004175 endopeptidase activity GSVIVG01024037001 1570599 1575263 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0019773 proteasome core complex, alpha-subunit complex The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. IEA GO:0004175 endopeptidase activity GSVIVG01024037001 1570599 1575263 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005839 proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. IEA Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. IEA GO:0004298 threonine-type endopeptidase activity GSVIVG01024037001 1570599 1575263 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0019773 proteasome core complex, alpha-subunit complex The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. IEA GO:0004298 threonine-type endopeptidase activity GSVIVG01024037001 1570599 1575263 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0005839 proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. IEA Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. IEA GO:0004298 threonine-type endopeptidase activity GSVIVG01024037001 1570599 1575263 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0019773 proteasome core complex, alpha-subunit complex The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. IEA GO:0004298 threonine-type endopeptidase activity GSVIVG01014097001 356889 371743 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01021923001 5526617 5527507 GSVIVG01017103001 4178583 4181891 GSVIVG01032007001 23604022 23631345 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032007001 23604022 23631345 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01032007001 23604022 23631345 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01031315001 432692 438118 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01031315001 432692 438118 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01031315001 432692 438118 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01031315001 432692 438118 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01031315001 432692 438118 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019008001 17864181 17864801 GSVIVG01029527001 21929401 21952613 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029527001 21929401 21952613 Catalysis of the transfer of a functional group from one position to another within a single molecule. IEA GO:0016866 intramolecular transferase activity GSVIVG01001449001 21114375 21118252 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031155001 1654894 1659347 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000125001 15472658 15474259 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01011896001 3204590 3205665 GSVIVG01013986001 8500169 8503034 GO:0016459 myosin complex A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. IEA Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate. IEA GO:0003774 motor activity GSVIVG01013986001 8500169 8503034 GO:0016459 myosin complex A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000602001 6624950 6628677 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01000602001 6624950 6628677 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033511001 20145812 20170670 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01033511001 20145812 20170670 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01033511001 20145812 20170670 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01033511001 20145812 20170670 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028711001 19519389 19529594 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01028711001 19519389 19529594 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01028711001 19519389 19529594 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01028711001 19519389 19529594 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01028711001 19519389 19529594 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01028711001 19519389 19529594 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01001544001 1378825 1379264 GSVIVG01021063001 14235488 14238846 GSVIVG01023534001 10123012 10123538 GSVIVG01016909001 2460725 2461970 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01016909001 2460725 2461970 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020182001 9342575 9344861 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020182001 9342575 9344861 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01020182001 9342575 9344861 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01020182001 9342575 9344861 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01020182001 9342575 9344861 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032554001 28316847 28319790 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01005104001 18148150 18148669 GSVIVG01035076001 1307369 1308279 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GSVIVG01035076001 1307369 1308279 GO:0009607 response to biotic stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism. IEA GSVIVG01033398001 20962202 20968355 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033398001 20962202 20968355 GO:0006012 galactose metabolic process The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033398001 20962202 20968355 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: UDP-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-galactose. IEA GO:0008108 UDP-glucose:hexose-1-phosphate uridylyltransferase activity GSVIVG01033398001 20962202 20968355 GO:0006012 galactose metabolic process The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. IEA Catalysis of the reaction: UDP-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-galactose. IEA GO:0008108 UDP-glucose:hexose-1-phosphate uridylyltransferase activity GSVIVG01033398001 20962202 20968355 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01033398001 20962202 20968355 GO:0006012 galactose metabolic process The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01033398001 20962202 20968355 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01033398001 20962202 20968355 GO:0006012 galactose metabolic process The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01033398001 20962202 20968355 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the transfer of a nucleotidyl group to a reactant. IEA GO:0016779 nucleotidyltransferase activity GSVIVG01033398001 20962202 20968355 GO:0006012 galactose metabolic process The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. IEA Catalysis of the transfer of a nucleotidyl group to a reactant. IEA GO:0016779 nucleotidyltransferase activity GSVIVG01033398001 20962202 20968355 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01033398001 20962202 20968355 GO:0006012 galactose metabolic process The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01019082001 16896541 16897919 GSVIVG01032926001 24222538 24225772 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01019889001 4249304 4250807 GO:0009664 plant-type cell wall organization A process that results in the assembly and arrangement of constituent parts of the cellulose and pectin-containing cell wall, or in the disassembly of the cellulose and pectin-containing cell wall. This process is carried out at the cellular level. An example of this process is found in Arabidopsis thaliana. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA GSVIVG01015008001 404936 407256 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01015008001 404936 407256 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01006328001 24899525 24903526 GSVIVG01031969001 5801293 5802070 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01031969001 5801293 5802070 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01024748001 7240084 7241481 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals. IEA GO:0008519 ammonium transmembrane transporter activity GSVIVG01024748001 7240084 7241481 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals. IEA GO:0008519 ammonium transmembrane transporter activity GSVIVG01013280001 5692458 5701159 GO:0005956 protein kinase CK2 complex A protein complex that possesses protein serine/threonine kinase activity, and contains two catalytic alpha subunits and two regulatory beta subunits. Protein kinase CK2 complexes are found in nearly every subcellular compartment, and can phosphorylate many protein substrates in addition to casein. IEA Modulates the activity of a protein kinase, an enzyme which phosphorylates a protein. IEA GO:0019887 protein kinase regulator activity GSVIVG01035636001 2883265 2886368 GSVIVG01015713001 16198326 16210046 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+. IEA GO:0008121 ubiquinol-cytochrome-c reductase activity GSVIVG01015713001 16198326 16210046 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0042651 thylakoid membrane The pigmented membrane of any thylakoid. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+. IEA GO:0008121 ubiquinol-cytochrome-c reductase activity GSVIVG01015713001 16198326 16210046 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: plastoquinol-1 + 2 oxidized plastocyanin = plastoquinone + 2 reduced plastocyanin. IEA GO:0009496 plastoquinol-plastocyanin reductase activity GSVIVG01015713001 16198326 16210046 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0042651 thylakoid membrane The pigmented membrane of any thylakoid. IEA Catalysis of the reaction: plastoquinol-1 + 2 oxidized plastocyanin = plastoquinone + 2 reduced plastocyanin. IEA GO:0009496 plastoquinol-plastocyanin reductase activity GSVIVG01015713001 16198326 16210046 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01015713001 16198326 16210046 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0042651 thylakoid membrane The pigmented membrane of any thylakoid. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01015713001 16198326 16210046 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction in which a diphenol or related substance acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016679 oxidoreductase activity, acting on diphenols and related substances as donors GSVIVG01015713001 16198326 16210046 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0042651 thylakoid membrane The pigmented membrane of any thylakoid. IEA Catalysis of an oxidation-reduction (redox) reaction in which a diphenol or related substance acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016679 oxidoreductase activity, acting on diphenols and related substances as donors GSVIVG01015713001 16198326 16210046 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051537 2 iron, 2 sulfur cluster binding GSVIVG01015713001 16198326 16210046 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0042651 thylakoid membrane The pigmented membrane of any thylakoid. IEA Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051537 2 iron, 2 sulfur cluster binding GSVIVG01034764001 9237456 9239402 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01034764001 9237456 9239402 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01034764001 9237456 9239402 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01034764001 9237456 9239402 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01008085001 5938820 5950486 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta-adrenergic receptors; the activity involves transmitting the signal to the Gs alpha subunit of a heterotrimeric G protein. IEA GO:0004939 beta-adrenergic receptor activity GSVIVG01008085001 5938820 5950486 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta-adrenergic receptors; the activity involves transmitting the signal to the Gs alpha subunit of a heterotrimeric G protein. IEA GO:0004939 beta-adrenergic receptor activity GSVIVG01008085001 5938820 5950486 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta-adrenergic receptors; the activity involves transmitting the signal to the Gs alpha subunit of a heterotrimeric G protein. IEA GO:0004939 beta-adrenergic receptor activity GSVIVG01008085001 5938820 5950486 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta-adrenergic receptors; the activity involves transmitting the signal to the Gs alpha subunit of a heterotrimeric G protein. IEA GO:0004939 beta-adrenergic receptor activity GSVIVG01008085001 5938820 5950486 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta-adrenergic receptors; the activity involves transmitting the signal to the Gs alpha subunit of a heterotrimeric G protein. IEA GO:0004939 beta-adrenergic receptor activity GSVIVG01008085001 5938820 5950486 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta-adrenergic receptors; the activity involves transmitting the signal to the Gs alpha subunit of a heterotrimeric G protein. IEA GO:0004939 beta-adrenergic receptor activity GSVIVG01008085001 5938820 5950486 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01008085001 5938820 5950486 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01008085001 5938820 5950486 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01008085001 5938820 5950486 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01008085001 5938820 5950486 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01008085001 5938820 5950486 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01008085001 5938820 5950486 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel, where the inward rectification is due to a voltage-dependent block of the channel pore by ATP. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. IEA GO:0015272 ATP-activated inward rectifier potassium channel activity GSVIVG01008085001 5938820 5950486 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel, where the inward rectification is due to a voltage-dependent block of the channel pore by ATP. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. IEA GO:0015272 ATP-activated inward rectifier potassium channel activity GSVIVG01008085001 5938820 5950486 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel, where the inward rectification is due to a voltage-dependent block of the channel pore by ATP. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. IEA GO:0015272 ATP-activated inward rectifier potassium channel activity GSVIVG01008085001 5938820 5950486 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel, where the inward rectification is due to a voltage-dependent block of the channel pore by ATP. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. IEA GO:0015272 ATP-activated inward rectifier potassium channel activity GSVIVG01008085001 5938820 5950486 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel, where the inward rectification is due to a voltage-dependent block of the channel pore by ATP. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. IEA GO:0015272 ATP-activated inward rectifier potassium channel activity GSVIVG01008085001 5938820 5950486 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel, where the inward rectification is due to a voltage-dependent block of the channel pore by ATP. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. IEA GO:0015272 ATP-activated inward rectifier potassium channel activity GSVIVG01013267001 5999581 6000966 GSVIVG01030006001 8890307 8891860 GSVIVG01033709001 18427704 18443167 GSVIVG01005133001 18477222 18481502 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GSVIVG01001830001 26151738 26165522 Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01001830001 26151738 26165522 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01001830001 26151738 26165522 Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01011576001 6306239 6307845 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01032317001 15032948 15033885 GSVIVG01010726001 21845072 21848020 GSVIVG01021317001 3961135 3964157 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01035829001 4716174 4719590 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035829001 4716174 4719590 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01035829001 4716174 4719590 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01035829001 4716174 4719590 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01013354001 1054582 1057697 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01013354001 1054582 1057697 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01013354001 1054582 1057697 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01013354001 1054582 1057697 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01014884001 11155237 11155722 GSVIVG01004798001 177605 178887 GSVIVG01008648001 116408 141670 GSVIVG01031114001 2053704 2057478 GSVIVG01014992001 50875 135029 GSVIVG01020051001 11080253 11083113 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01010372001 19913049 19914939 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01010372001 19913049 19914939 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010372001 19913049 19914939 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01018854001 19221792 19223454 GO:0000154 rRNA modification The covalent alteration of one or more nucleotides within an rRNA molecule to produce an rRNA molecule with a sequence that differs from that coded genetically. IEA Catalysis of the dimethylation two adjacent A residues in the loop closing the 3'-terminal stem of the 18S rRNA, using S-adenosyl-L-methionine as a methyl donor. IEA GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity GSVIVG01018854001 19221792 19223454 GO:0006364 rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. IEA Catalysis of the dimethylation two adjacent A residues in the loop closing the 3'-terminal stem of the 18S rRNA, using S-adenosyl-L-methionine as a methyl donor. IEA GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity GSVIVG01018854001 19221792 19223454 GO:0000154 rRNA modification The covalent alteration of one or more nucleotides within an rRNA molecule to produce an rRNA molecule with a sequence that differs from that coded genetically. IEA Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule. IEA GO:0008649 rRNA methyltransferase activity GSVIVG01018854001 19221792 19223454 GO:0006364 rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. IEA Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule. IEA GO:0008649 rRNA methyltransferase activity GSVIVG01018854001 19221792 19223454 GO:0000154 rRNA modification The covalent alteration of one or more nucleotides within an rRNA molecule to produce an rRNA molecule with a sequence that differs from that coded genetically. IEA Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to an adenine residue in an rRNA molecule. IEA GO:0016433 rRNA (adenine) methyltransferase activity GSVIVG01018854001 19221792 19223454 GO:0006364 rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. IEA Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to an adenine residue in an rRNA molecule. IEA GO:0016433 rRNA (adenine) methyltransferase activity GSVIVG01006068001 41055564 41057417 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01006068001 41055564 41057417 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01006068001 41055564 41057417 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01006068001 41055564 41057417 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021229001 2784201 2784920 GSVIVG01018799001 19753119 19761316 GO:0019538 protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification. IEA Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide. IEA GO:0016671 oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor GSVIVG01018799001 19753119 19761316 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide. IEA GO:0016671 oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor GSVIVG01036385001 4501818 4505052 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01036385001 4501818 4505052 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0070469 respiratory chain The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01036385001 4501818 4505052 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01036385001 4501818 4505052 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0070469 respiratory chain The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01036385001 4501818 4505052 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01036385001 4501818 4505052 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0070469 respiratory chain The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01036385001 4501818 4505052 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01036385001 4501818 4505052 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0070469 respiratory chain The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01036385001 4501818 4505052 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01036385001 4501818 4505052 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0070469 respiratory chain The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01036385001 4501818 4505052 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01036385001 4501818 4505052 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0070469 respiratory chain The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01036385001 4501818 4505052 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01036385001 4501818 4505052 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0070469 respiratory chain The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01036385001 4501818 4505052 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01036385001 4501818 4505052 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0070469 respiratory chain The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01023380001 19171373 19178342 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01001690001 14296312 14329573 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01001690001 14296312 14329573 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01001690001 14296312 14329573 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01001690001 14296312 14329573 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01001690001 14296312 14329573 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01001690001 14296312 14329573 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01001690001 14296312 14329573 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001690001 14296312 14329573 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001690001 14296312 14329573 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. IEA GO:0016597 amino acid binding GSVIVG01001690001 14296312 14329573 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. IEA GO:0016597 amino acid binding GSVIVG01014048001 10048723 10050591 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01029979001 2636746 2653598 GSVIVG01004516001 38979537 38985287 GSVIVG01011838001 3730702 3738630 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01011124001 1383099 1386663 GSVIVG01001492001 5143158 5144747 GSVIVG01033617001 19238235 19239711 GSVIVG01036340001 3960557 3961361 Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01036340001 3960557 3961361 Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01021871001 6237011 6240389 GSVIVG01002189001 33177826 33179259 GSVIVG01022838001 18886859 18897550 GSVIVG01011199001 9345284 9347978 GSVIVG01014248001 1981264 1985197 GO:0006559 L-phenylalanine catabolic process The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid. IEA Catalysis of the reaction: homogentisate + O2 = 4-maleylacetoacetate. IEA GO:0004411 homogentisate 1,2-dioxygenase activity GSVIVG01014248001 1981264 1985197 GO:0006570 tyrosine metabolic process The chemical reactions and pathways involving tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid. IEA Catalysis of the reaction: homogentisate + O2 = 4-maleylacetoacetate. IEA GO:0004411 homogentisate 1,2-dioxygenase activity GSVIVG01014248001 1981264 1985197 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: homogentisate + O2 = 4-maleylacetoacetate. IEA GO:0004411 homogentisate 1,2-dioxygenase activity GSVIVG01008408001 2368190 2377747 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01008408001 2368190 2377747 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01008408001 2368190 2377747 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli. IEA GO:0004707 MAP kinase activity GSVIVG01008408001 2368190 2377747 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01008408001 2368190 2377747 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023430001 12179212 12179564 GSVIVG01022226001 17663976 17669603 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01022226001 17663976 17669603 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01022226001 17663976 17669603 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01022226001 17663976 17669603 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01014006001 8843480 8843725 GSVIVG01012705001 845549 851376 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA GSVIVG01003100001 8682735 8702901 GSVIVG01010224001 17884032 17888603 GSVIVG01027285001 17180680 17187846 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027285001 17180680 17187846 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01020789001 1950336 1955132 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01020789001 1950336 1955132 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01031976001 5851028 5859014 GSVIVG01002708001 35944450 35946460 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01002708001 35944450 35946460 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). IEA GO:0016769 transferase activity, transferring nitrogenous groups GSVIVG01002708001 35944450 35946460 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + methylthioadenosine. IEA GO:0016847 1-aminocyclopropane-1-carboxylate synthase activity GSVIVG01002708001 35944450 35946460 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01010112001 15701474 15704472 GSVIVG01025409001 1004954 1013231 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0016272 prefoldin complex A multisubunit chaperone that acts to delivers unfolded proteins to cytosolic chaperonin. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01019158001 15933940 15957362 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01019158001 15933940 15957362 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01019158001 15933940 15957362 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01019158001 15933940 15957362 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01001473001 21376505 21382625 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013135001 7838288 7840566 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01013135001 7838288 7840566 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01013135001 7838288 7840566 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01013135001 7838288 7840566 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01013135001 7838288 7840566 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01013135001 7838288 7840566 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01000425001 7808538 7812910 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01000425001 7808538 7812910 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01000425001 7808538 7812910 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01000425001 7808538 7812910 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01000425001 7808538 7812910 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01000425001 7808538 7812910 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01000425001 7808538 7812910 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000425001 7808538 7812910 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000425001 7808538 7812910 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01000425001 7808538 7812910 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01025882001 27505818 27508135 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01025882001 27505818 27508135 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025882001 27505818 27508135 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01025882001 27505818 27508135 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01001284001 4974657 4978139 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01001284001 4974657 4978139 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01001284001 4974657 4978139 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01001284001 4974657 4978139 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01001284001 4974657 4978139 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001284001 4974657 4978139 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001284001 4974657 4978139 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01001284001 4974657 4978139 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01001284001 4974657 4978139 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01001284001 4974657 4978139 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01031639001 19402091 19438833 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031639001 19402091 19438833 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031639001 19402091 19438833 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031639001 19402091 19438833 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031639001 19402091 19438833 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01031639001 19402091 19438833 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01031639001 19402091 19438833 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01031639001 19402091 19438833 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01001147001 1315016 1316685 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with a leukotriene to initiate a change in cell activity. Leukotrienes are pharmacologically active substances with a set of three conjugated double bonds; some contain a peptide moiety based on cysteine. IEA GO:0004974 leukotriene receptor activity GSVIVG01001147001 1315016 1316685 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The action of a molecule that contributes to the structural integrity of a cell wall. IEA GO:0005199 structural constituent of cell wall GSVIVG01001147001 1315016 1316685 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01001147001 1315016 1316685 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01010463001 20788641 20805175 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01010463001 20788641 20805175 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. IEA GO:0008171 O-methyltransferase activity GSVIVG01010463001 20788641 20805175 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01029104001 19668227 19668972 GSVIVG01000144001 15621175 15622997 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01000144001 15621175 15622997 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01000144001 15621175 15622997 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01000144001 15621175 15622997 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01025697001 12880190 12882690 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025697001 12880190 12882690 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01020921001 17105412 17127003 GSVIVG01017639001 2201430 2203055 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01017639001 2201430 2203055 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. IEA GO:0004722 protein serine/threonine phosphatase activity GSVIVG01017146001 4632649 4635980 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017146001 4632649 4635980 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017146001 4632649 4635980 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017146001 4632649 4635980 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023866001 2890432 2895797 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01023866001 2890432 2895797 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01023866001 2890432 2895797 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01023866001 2890432 2895797 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01023866001 2890432 2895797 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023866001 2890432 2895797 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017786001 3470105 3470416 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01017786001 3470105 3470416 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds. IEA GO:0015035 protein disulfide oxidoreductase activity GSVIVG01035446001 1336306 1338118 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01035446001 1336306 1338118 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01035446001 1336306 1338118 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01035446001 1336306 1338118 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001758001 6210599 6211050 GSVIVG01005232001 19612955 19619497 Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum. IEA GO:0003993 acid phosphatase activity GSVIVG01005232001 19612955 19619497 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01005232001 19612955 19619497 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01036404001 4689784 4692407 GSVIVG01030737001 14809003 14809212 GSVIVG01037664001 6671393 6678633 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid. IEA GO:0008378 galactosyltransferase activity GSVIVG01037664001 6671393 6678633 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid. IEA GO:0008378 galactosyltransferase activity GSVIVG01037664001 6671393 6678633 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid. IEA GO:0008378 galactosyltransferase activity GSVIVG01037664001 6671393 6678633 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01037664001 6671393 6678633 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01037664001 6671393 6678633 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01037664001 6671393 6678633 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01037664001 6671393 6678633 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01037664001 6671393 6678633 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01000056001 3125791 3127745 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01000056001 3125791 3127745 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01037903001 6507405 6509263 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01003424001 14873099 14881696 GSVIVG01021962001 5047482 5066237 GSVIVG01024997001 5401162 5404988 GSVIVG01010934001 15402680 15408215 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010934001 15402680 15408215 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01008580001 743853 744203 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008580001 743853 744203 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008580001 743853 744203 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008580001 743853 744203 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008580001 743853 744203 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008580001 743853 744203 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01012006001 2251732 2252693 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01017081001 4052254 4053727 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01017081001 4052254 4053727 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01008806001 2291789 2294142 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01008806001 2291789 2294142 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01008806001 2291789 2294142 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01008806001 2291789 2294142 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01008806001 2291789 2294142 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01008806001 2291789 2294142 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01008806001 2291789 2294142 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01008806001 2291789 2294142 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01008806001 2291789 2294142 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01025835001 11382526 11393658 GSVIVG01008621001 337604 343588 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008621001 337604 343588 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008621001 337604 343588 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01008621001 337604 343588 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01008621001 337604 343588 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). IEA GO:0016769 transferase activity, transferring nitrogenous groups GSVIVG01008621001 337604 343588 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). IEA GO:0016769 transferase activity, transferring nitrogenous groups GSVIVG01008621001 337604 343588 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01008621001 337604 343588 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01030048001 9145830 9150613 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01030048001 9145830 9150613 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01030048001 9145830 9150613 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01025831001 11422958 11425757 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01013476001 70305 92437 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01013476001 70305 92437 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01035940001 6200586 6211153 GSVIVG01016920001 2574185 2575919 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01016920001 2574185 2575919 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01016920001 2574185 2575919 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028755001 19158252 19164166 GSVIVG01002223001 33513352 33519085 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01002223001 33513352 33519085 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01002223001 33513352 33519085 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01002223001 33513352 33519085 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016358001 4558888 4572397 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01020867001 793725 798123 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01009560001 9420171 9429185 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004185 serine-type carboxypeptidase activity GSVIVG01025772001 12058926 12061253 GSVIVG01008000001 6793108 6793548 GSVIVG01038534001 11177147 11191978 GSVIVG01032458001 27631420 27634351 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032458001 27631420 27634351 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032458001 27631420 27634351 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032458001 27631420 27634351 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032458001 27631420 27634351 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032458001 27631420 27634351 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032458001 27631420 27634351 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01032458001 27631420 27634351 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01032458001 27631420 27634351 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01032458001 27631420 27634351 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01032458001 27631420 27634351 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01032458001 27631420 27634351 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01029301001 17334294 17336903 GSVIVG01023582001 7601963 7604681 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01023582001 7601963 7604681 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01028341001 6281555 6283600 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Functions in the storage of nutritious substrates. IEA GO:0045735 nutrient reservoir activity GSVIVG01000760001 483072 486493 GSVIVG01015879001 18899576 18902065 GSVIVG01026683001 4804943 4805164 GSVIVG01009199001 6095228 6184479 GSVIVG01004815001 131804 137427 GSVIVG01031538001 17368209 17371474 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01031538001 17368209 17371474 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01031538001 17368209 17371474 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01000974001 10987686 10995948 GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01000974001 10987686 10995948 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01004033001 14355287 14357303 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030169001 10883491 10889826 GSVIVG01017559001 10535730 10538823 GSVIVG01019375001 139881 140353 GSVIVG01020550001 4467432 4468225 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GSVIVG01020550001 4467432 4468225 GO:0009607 response to biotic stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism. IEA GSVIVG01015736001 16647757 16648117 GSVIVG01002061001 32585017 32587977 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01002061001 32585017 32587977 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01002061001 32585017 32587977 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01002061001 32585017 32587977 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01002061001 32585017 32587977 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01002061001 32585017 32587977 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01002061001 32585017 32587977 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01002061001 32585017 32587977 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027101001 17932987 17940277 GSVIVG01014247001 1953375 1979475 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01013318001 11862965 11863481 GSVIVG01028756001 19150698 19157465 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01028756001 19150698 19157465 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028756001 19150698 19157465 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the reaction: ATP + pyruvate = ADP + phosphoenolpyruvate. IEA GO:0004743 pyruvate kinase activity GSVIVG01028756001 19150698 19157465 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01028756001 19150698 19157465 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01028756001 19150698 19157465 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Interacting selectively and non-covalently with potassium (K+) ions. IEA GO:0030955 potassium ion binding GSVIVG01020419001 19731050 19731340 GSVIVG01000521001 13597404 13599563 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000521001 13597404 13599563 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000521001 13597404 13599563 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01000521001 13597404 13599563 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01028306001 5941442 5942809 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01028306001 5941442 5942809 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01002583001 35308253 35312350 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005945 6-phosphofructokinase complex A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known. IEA Catalysis of the reaction: ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate. IEA GO:0003872 6-phosphofructokinase activity GSVIVG01002583001 35308253 35312350 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005945 6-phosphofructokinase complex A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033736001 18228341 18233371 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033736001 18228341 18233371 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01033736001 18228341 18233371 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01033736001 18228341 18233371 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01000458001 8182426 8183956 GSVIVG01006633001 27164412 27173268 GSVIVG01035965001 6569931 6576637 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01035965001 6569931 6576637 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01026378001 15315051 15315545 GO:0006519 cellular amino acid and derivative metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026378001 15315051 15315545 GO:0019752 carboxylic acid metabolic process The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026378001 15315051 15315545 GO:0006519 cellular amino acid and derivative metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells. IEA Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. IEA GO:0016831 carboxy-lyase activity GSVIVG01026378001 15315051 15315545 GO:0019752 carboxylic acid metabolic process The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). IEA Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. IEA GO:0016831 carboxy-lyase activity GSVIVG01026378001 15315051 15315545 GO:0006519 cellular amino acid and derivative metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01026378001 15315051 15315545 GO:0019752 carboxylic acid metabolic process The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01005268001 20036538 20038914 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01005268001 20036538 20038914 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01007273001 1211113 1213743 GSVIVG01027143001 17463925 17473125 GSVIVG01004082001 14659333 14669460 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01012885001 6512045 6512344 GSVIVG01032704001 1371082 1382312 GSVIVG01018744001 20260684 20262824 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01007839001 8528864 8536897 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01015391001 3236349 3243796 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01015391001 3236349 3243796 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010608001 16080849 16081797 GO:0006808 regulation of nitrogen utilization Any process that modulates the frequency, rate or extent of nitrogen utilization. IEA Modulates the activity of an enzyme. IEA GO:0030234 enzyme regulator activity GSVIVG01033051001 25344268 25355630 GSVIVG01019592001 1812388 1814056 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01019592001 1812388 1814056 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01004842001 5592160 5598339 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01008763001 1781659 1782994 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01008763001 1781659 1782994 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01008763001 1781659 1782994 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01008763001 1781659 1782994 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01029230001 18261124 18289539 GSVIVG01021333001 4143873 4165767 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01017865001 4117626 4127404 GSVIVG01029620001 20648320 20648529 GSVIVG01018926001 18596951 18597674 GSVIVG01016933001 2679371 2685354 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01016933001 2679371 2685354 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01016933001 2679371 2685354 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01016933001 2679371 2685354 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016933001 2679371 2685354 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007932001 7424475 7429523 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01007932001 7424475 7429523 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01011569001 6416961 6418730 GSVIVG01037105001 29105344 29106206 GSVIVG01028189001 4503236 4507819 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01026455001 23288719 23356942 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01026455001 23288719 23356942 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01026455001 23288719 23356942 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01026455001 23288719 23356942 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01026455001 23288719 23356942 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01026455001 23288719 23356942 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01026455001 23288719 23356942 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and primer. IEA GO:0003887 DNA-directed DNA polymerase activity GSVIVG01026455001 23288719 23356942 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and primer. IEA GO:0003887 DNA-directed DNA polymerase activity GSVIVG01012143001 1082207 1082935 GO:0006506 GPI anchor biosynthetic process The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol moiety is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate moiety, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + phosphatidylinositol = UDP + N-acetyl-D-glucosaminylphosphatidylinositol. IEA GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity GSVIVG01017935001 4851997 4853925 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01017935001 4851997 4853925 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01017935001 4851997 4853925 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01017935001 4851997 4853925 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01017935001 4851997 4853925 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01017935001 4851997 4853925 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01017935001 4851997 4853925 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01017935001 4851997 4853925 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01010662001 15417191 15418778 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010662001 15417191 15418778 GO:0008299 isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010662001 15417191 15418778 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA. IEA GO:0004421 hydroxymethylglutaryl-CoA synthase activity GSVIVG01010662001 15417191 15418778 GO:0008299 isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. IEA Catalysis of the reaction: acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA. IEA GO:0004421 hydroxymethylglutaryl-CoA synthase activity GSVIVG01033382001 21051749 21068082 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01026405001 15680403 15687686 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01026405001 15680403 15687686 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01026405001 15680403 15687686 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026405001 15680403 15687686 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026405001 15680403 15687686 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of the reaction: violaxanthin + 2 ascorbate = zeaxanthin + 2 dehydroascorbate + 2 H2O; also antheraxanthin + ascorbate = zeaxanthin + dehydroascorbate + H2O. IEA GO:0046422 violaxanthin de-epoxidase activity GSVIVG01026405001 15680403 15687686 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of the reaction: violaxanthin + 2 ascorbate = zeaxanthin + 2 dehydroascorbate + 2 H2O; also antheraxanthin + ascorbate = zeaxanthin + dehydroascorbate + H2O. IEA GO:0046422 violaxanthin de-epoxidase activity GSVIVG01021804001 7149380 7152574 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021804001 7149380 7152574 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021804001 7149380 7152574 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021804001 7149380 7152574 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021804001 7149380 7152574 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01021804001 7149380 7152574 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01021804001 7149380 7152574 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01021804001 7149380 7152574 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01021804001 7149380 7152574 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021804001 7149380 7152574 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021804001 7149380 7152574 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021804001 7149380 7152574 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021804001 7149380 7152574 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of calcium (Ca) ions from one side of a membrane to the other. IEA GO:0015085 calcium ion transmembrane transporter activity GSVIVG01021804001 7149380 7152574 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of calcium (Ca) ions from one side of a membrane to the other. IEA GO:0015085 calcium ion transmembrane transporter activity GSVIVG01021804001 7149380 7152574 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of calcium (Ca) ions from one side of a membrane to the other. IEA GO:0015085 calcium ion transmembrane transporter activity GSVIVG01021804001 7149380 7152574 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of calcium (Ca) ions from one side of a membrane to the other. IEA GO:0015085 calcium ion transmembrane transporter activity GSVIVG01021804001 7149380 7152574 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01021804001 7149380 7152574 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01021804001 7149380 7152574 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01021804001 7149380 7152574 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01021804001 7149380 7152574 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01021804001 7149380 7152574 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01021804001 7149380 7152574 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01021804001 7149380 7152574 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01006348001 25102936 25105073 GSVIVG01026180001 13488219 13496406 GSVIVG01001405001 18675720 18680201 GSVIVG01008656001 68010 69620 GSVIVG01038507001 10688976 10693463 GSVIVG01018675001 11311623 11312648 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GSVIVG01036497001 22687059 22687869 GSVIVG01021749001 10483623 10493286 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021749001 10483623 10493286 GO:0006012 galactose metabolic process The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021749001 10483623 10493286 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021749001 10483623 10493286 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021749001 10483623 10493286 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021749001 10483623 10493286 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021749001 10483623 10493286 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: UDP-glucose = UDP-galactose. IEA GO:0003978 UDP-glucose 4-epimerase activity GSVIVG01021749001 10483623 10493286 GO:0006012 galactose metabolic process The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. IEA Catalysis of the reaction: UDP-glucose = UDP-galactose. IEA GO:0003978 UDP-glucose 4-epimerase activity GSVIVG01021749001 10483623 10493286 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the reaction: UDP-glucose = UDP-galactose. IEA GO:0003978 UDP-glucose 4-epimerase activity GSVIVG01021749001 10483623 10493286 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: UDP-glucose = UDP-galactose. IEA GO:0003978 UDP-glucose 4-epimerase activity GSVIVG01021749001 10483623 10493286 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: UDP-glucose = UDP-galactose. IEA GO:0003978 UDP-glucose 4-epimerase activity GSVIVG01021749001 10483623 10493286 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of the reaction: UDP-glucose = UDP-galactose. IEA GO:0003978 UDP-glucose 4-epimerase activity GSVIVG01021749001 10483623 10493286 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01021749001 10483623 10493286 GO:0006012 galactose metabolic process The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01021749001 10483623 10493286 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01021749001 10483623 10493286 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01021749001 10483623 10493286 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01021749001 10483623 10493286 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01021749001 10483623 10493286 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01021749001 10483623 10493286 GO:0006012 galactose metabolic process The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01021749001 10483623 10493286 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01021749001 10483623 10493286 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01021749001 10483623 10493286 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01021749001 10483623 10493286 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01021749001 10483623 10493286 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. IEA GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GSVIVG01021749001 10483623 10493286 GO:0006012 galactose metabolic process The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. IEA Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. IEA GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GSVIVG01021749001 10483623 10493286 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. IEA GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GSVIVG01021749001 10483623 10493286 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. IEA GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GSVIVG01021749001 10483623 10493286 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. IEA GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GSVIVG01021749001 10483623 10493286 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. IEA GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GSVIVG01021749001 10483623 10493286 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01021749001 10483623 10493286 GO:0006012 galactose metabolic process The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01021749001 10483623 10493286 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01021749001 10483623 10493286 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01021749001 10483623 10493286 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01021749001 10483623 10493286 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01010682001 11614796 11626584 GSVIVG01004775001 15980182 15985853 GO:0005992 trehalose biosynthetic process The chemical reactions and pathways resulting in the formation of trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01004775001 15980182 15985853 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01004775001 15980182 15985853 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01004775001 15980182 15985853 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01004775001 15980182 15985853 GO:0005992 trehalose biosynthetic process The chemical reactions and pathways resulting in the formation of trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01004775001 15980182 15985853 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01004775001 15980182 15985853 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01004775001 15980182 15985853 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01004775001 15980182 15985853 GO:0005992 trehalose biosynthetic process The chemical reactions and pathways resulting in the formation of trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01004775001 15980182 15985853 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01004775001 15980182 15985853 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01004775001 15980182 15985853 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01024199001 380765 396708 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01024199001 380765 396708 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01024199001 380765 396708 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01024199001 380765 396708 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01018875001 19042212 19049128 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GSVIVG01012076001 1610162 1612639 Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01012076001 1610162 1612639 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01012076001 1610162 1612639 Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01026433001 23649616 23652801 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other. IEA GO:0005337 nucleoside transmembrane transporter activity GSVIVG01026433001 23649616 23652801 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other. IEA GO:0005337 nucleoside transmembrane transporter activity GSVIVG01026433001 23649616 23652801 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other. IEA GO:0005337 nucleoside transmembrane transporter activity GSVIVG01026433001 23649616 23652801 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other. IEA GO:0005337 nucleoside transmembrane transporter activity GSVIVG01035841001 4793095 4794952 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01035841001 4793095 4794952 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01035841001 4793095 4794952 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01035841001 4793095 4794952 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000108001 15331693 15344387 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). IEA GO:0003755 peptidyl-prolyl cis-trans isomerase activity GSVIVG01000108001 15331693 15344387 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). IEA GO:0003755 peptidyl-prolyl cis-trans isomerase activity GSVIVG01000108001 15331693 15344387 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01000108001 15331693 15344387 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01020284001 21901990 21911420 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01025415001 985933 987938 GSVIVG01024475001 3093749 3097459 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024475001 3093749 3097459 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024475001 3093749 3097459 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024475001 3093749 3097459 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024475001 3093749 3097459 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024475001 3093749 3097459 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024475001 3093749 3097459 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024475001 3093749 3097459 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024475001 3093749 3097459 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024475001 3093749 3097459 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor GSVIVG01024475001 3093749 3097459 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor GSVIVG01024475001 3093749 3097459 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor GSVIVG01016409001 4167701 4179083 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01011822001 3838318 3843025 GSVIVG01021441001 5378307 5385100 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01021441001 5378307 5385100 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01021441001 5378307 5385100 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021441001 5378307 5385100 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021441001 5378307 5385100 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01021441001 5378307 5385100 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01021441001 5378307 5385100 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021441001 5378307 5385100 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021441001 5378307 5385100 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01021441001 5378307 5385100 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01021441001 5378307 5385100 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01021441001 5378307 5385100 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01014670001 8407035 8408225 GO:0006099 tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01014670001 8407035 8408225 GO:0006099 tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. IEA Catalysis of the reaction: phosphate + oxaloacetate = H2O + phosphoenolpyruvate + CO2. IEA GO:0008964 phosphoenolpyruvate carboxylase activity GSVIVG01010394001 20110753 20122015 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01010394001 20110753 20122015 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01008298001 3488430 3511867 GO:0006955 immune response Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with the interleukin-5 receptor. IEA GO:0005137 interleukin-5 receptor binding GSVIVG01008298001 3488430 3511867 GO:0006955 immune response Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation. IEA GO:0008083 growth factor activity GSVIVG01000642001 20315952 20324754 GSVIVG01006946001 29213966 29218461 GSVIVG01032294001 14642949 14646150 GSVIVG01020905001 17485623 17488917 GSVIVG01032558001 28358502 28360058 GSVIVG01025890001 27443176 27445765 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036616001 19261129 19272210 GSVIVG01014834001 10331314 10331967 GSVIVG01019398001 317023 321160 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01011848001 3658682 3665483 GSVIVG01033358001 21237910 21239208 GSVIVG01005919001 793294 828610 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01005919001 793294 828610 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01005919001 793294 828610 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01005919001 793294 828610 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01005919001 793294 828610 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01005919001 793294 828610 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01005919001 793294 828610 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01005919001 793294 828610 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01009272001 6852092 6857755 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009272001 6852092 6857755 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01009272001 6852092 6857755 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01009924001 12432435 12439491 Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01003273001 8650556 8651580 GSVIVG01028979001 16936320 16939272 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033179 proton-transporting V-type ATPase, V0 domain A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01037137001 28739956 28746106 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01037137001 28739956 28746106 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01029832001 276269 277315 GSVIVG01026185001 13578039 13579973 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01026185001 13578039 13579973 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01026185001 13578039 13579973 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01026185001 13578039 13579973 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036115001 20538057 20541507 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01036115001 20538057 20541507 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01036115001 20538057 20541507 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01036115001 20538057 20541507 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01036115001 20538057 20541507 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. IEA GO:0005516 calmodulin binding GSVIVG01036115001 20538057 20541507 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. IEA GO:0005516 calmodulin binding GSVIVG01036115001 20538057 20541507 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036115001 20538057 20541507 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021847001 6585901 6593049 GSVIVG01015074001 856259 860336 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01015074001 856259 860336 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01015074001 856259 860336 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01015074001 856259 860336 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor. IEA GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen GSVIVG01015074001 856259 860336 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01015074001 856259 860336 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01001059001 7181211 7182743 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001059001 7181211 7182743 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001059001 7181211 7182743 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001059001 7181211 7182743 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01001059001 7181211 7182743 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01001059001 7181211 7182743 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01001059001 7181211 7182743 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01001059001 7181211 7182743 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01001059001 7181211 7182743 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01001059001 7181211 7182743 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01001059001 7181211 7182743 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01001059001 7181211 7182743 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01001059001 7181211 7182743 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01001059001 7181211 7182743 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01001059001 7181211 7182743 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01001059001 7181211 7182743 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01001059001 7181211 7182743 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01001059001 7181211 7182743 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01012114001 1316104 1326207 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of potassium ions (K+) from one side of a membrane to the other. IEA GO:0015079 potassium ion transmembrane transporter activity GSVIVG01035227001 10832627 10833305 GSVIVG01024221001 110953 117181 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024221001 110953 117181 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01024221001 110953 117181 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01024221001 110953 117181 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01021667001 8988752 8993501 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01021667001 8988752 8993501 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01021667001 8988752 8993501 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01021667001 8988752 8993501 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01021667001 8988752 8993501 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016570001 2694342 2695760 GSVIVG01009289001 7015411 7021201 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01024415001 2276450 2281638 GSVIVG01003242001 8207385 8207836 GSVIVG01008892001 3198721 3206947 GO:0006413 translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01008892001 3198721 3206947 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01008892001 3198721 3206947 GO:0006413 translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. IEA GO:0003743 translation initiation factor activity GSVIVG01008892001 3198721 3206947 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. IEA GO:0003743 translation initiation factor activity GSVIVG01013936001 7046274 7046625 GSVIVG01035662001 3104375 3110408 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035662001 3104375 3110408 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035662001 3104375 3110408 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. IEA GO:0008483 transaminase activity GSVIVG01035662001 3104375 3110408 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. IEA GO:0008483 transaminase activity GSVIVG01035662001 3104375 3110408 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). IEA GO:0016769 transferase activity, transferring nitrogenous groups GSVIVG01035662001 3104375 3110408 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). IEA GO:0016769 transferase activity, transferring nitrogenous groups GSVIVG01035662001 3104375 3110408 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01035662001 3104375 3110408 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01025127001 4195642 4196825 GO:0009052 pentose-phosphate shunt, non-oxidative branch The branch of the pentose-phosphate shunt which does not involve oxidation reactions. It comprises a series of sugar phosphate interconversions, starting with ribulose 5-P and producing fructose 6-P and glyceraldehyde 3-P. IEA Catalysis of the reaction: D-ribose 5-phosphate = D-ribulose 5-phosphate. IEA GO:0004751 ribose-5-phosphate isomerase activity GSVIVG01008660001 52747 54869 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01021195001 2471781 2472895 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004197 cysteine-type endopeptidase activity GSVIVG01021195001 2471781 2472895 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01033777001 17914116 17924867 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033777001 17914116 17924867 GO:0006284 base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033777001 17914116 17924867 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. IEA GO:0004519 endonuclease activity GSVIVG01033777001 17914116 17924867 GO:0006284 base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. IEA GO:0004519 endonuclease activity GSVIVG01033777001 17914116 17924867 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051539 4 iron, 4 sulfur cluster binding GSVIVG01033777001 17914116 17924867 GO:0006284 base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. IEA Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051539 4 iron, 4 sulfur cluster binding GSVIVG01027056001 18317651 18324864 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01027056001 18317651 18324864 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01027056001 18317651 18324864 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01027056001 18317651 18324864 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01027056001 18317651 18324864 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01027056001 18317651 18324864 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01027056001 18317651 18324864 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01027056001 18317651 18324864 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01027056001 18317651 18324864 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01027056001 18317651 18324864 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01027056001 18317651 18324864 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01027056001 18317651 18324864 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01027056001 18317651 18324864 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027056001 18317651 18324864 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027056001 18317651 18324864 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027056001 18317651 18324864 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027056001 18317651 18324864 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027056001 18317651 18324864 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027056001 18317651 18324864 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027056001 18317651 18324864 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027056001 18317651 18324864 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027056001 18317651 18324864 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027056001 18317651 18324864 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027056001 18317651 18324864 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01034604001 14535538 14540645 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01034604001 14535538 14540645 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01034604001 14535538 14540645 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01034604001 14535538 14540645 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020845001 1136978 1138579 GSVIVG01024663001 7959185 7967865 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01024663001 7959185 7967865 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021392001 4855823 4864560 GO:0006729 tetrahydrobiopterin biosynthetic process The chemical reactions and pathways resulting in the formation of tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine. IEA Catalysis of the reaction: (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4-alpha-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H2O. IEA GO:0008124 4-alpha-hydroxytetrahydrobiopterin dehydratase activity GSVIVG01034990001 720564 727760 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01034990001 720564 727760 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01034990001 720564 727760 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: ADP + phosphate + acetyl-CoA + oxaloacetate = ATP + citrate + CoA. IEA GO:0003878 ATP citrate synthase activity GSVIVG01034990001 720564 727760 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Catalysis of the reaction: ADP + phosphate + acetyl-CoA + oxaloacetate = ATP + citrate + CoA. IEA GO:0003878 ATP citrate synthase activity GSVIVG01034990001 720564 727760 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: ATP + succinate + CoA = ADP + succinyl-CoA + phosphate. IEA GO:0004775 succinate-CoA ligase (ADP-forming) activity GSVIVG01034990001 720564 727760 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Catalysis of the reaction: ATP + succinate + CoA = ADP + succinyl-CoA + phosphate. IEA GO:0004775 succinate-CoA ligase (ADP-forming) activity GSVIVG01034990001 720564 727760 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01034990001 720564 727760 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01034990001 720564 727760 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor), with the acyl group being converted into alkyl on transfer. IEA GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer GSVIVG01034990001 720564 727760 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor), with the acyl group being converted into alkyl on transfer. IEA GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer GSVIVG01030928001 19211208 19212047 GO:0032968 positive regulation of RNA elongation from RNA polymerase II promoter Any process that activates or increases the frequency, rate or extent of RNA elongation, the extension of an RNA molecule after transcription initiation by the addition of ribonucleotides, catalyzed by RNA polymerase II. IEA Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule following transcription initiation. IEA GO:0003711 transcription elongation regulator activity GSVIVG01001799001 3349680 3350171 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016471 vacuolar proton-transporting V-type ATPase complex A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01026804001 7498164 7498289 GSVIVG01018390001 9874378 9874542 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01037718001 7228123 7230884 GSVIVG01028813001 18484090 18489671 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005801 cis-Golgi network The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum. IEA GSVIVG01028813001 18484090 18489671 GO:0006888 ER to Golgi vesicle-mediated transport The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi. IEA GO:0005801 cis-Golgi network The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum. IEA GSVIVG01032489001 27825543 27827876 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01011278001 10458927 10459872 GSVIVG01032175001 21805560 21821577 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032175001 21805560 21821577 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032175001 21805560 21821577 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032175001 21805560 21821577 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032175001 21805560 21821577 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01032175001 21805560 21821577 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01011310001 8278489 8279835 GSVIVG01015340001 2814931 2821493 GO:0006479 protein amino acid methylation The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01015340001 2814931 2821493 GO:0006479 protein amino acid methylation The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a methyl group (CH3-) to a protein. IEA GO:0008276 protein methyltransferase activity GSVIVG01019294001 1788807 1789799 GSVIVG01024715001 7510826 7517504 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01024715001 7510826 7517504 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. IEA GO:0008080 N-acetyltransferase activity GSVIVG01024715001 7510826 7517504 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01000080001 3288594 3292318 GSVIVG01013275001 5785739 5790833 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01013275001 5785739 5790833 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01013275001 5785739 5790833 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01013275001 5785739 5790833 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025386001 1170566 1183851 GO:0006306 DNA methylation The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025386001 1170566 1183851 GO:0006306 DNA methylation The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025386001 1170566 1183851 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025386001 1170566 1183851 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025386001 1170566 1183851 GO:0006306 DNA methylation The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Interacting selectively and non-covalently with chromatin, the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase. IEA GO:0003682 chromatin binding GSVIVG01025386001 1170566 1183851 GO:0006306 DNA methylation The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with chromatin, the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase. IEA GO:0003682 chromatin binding GSVIVG01025386001 1170566 1183851 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Interacting selectively and non-covalently with chromatin, the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase. IEA GO:0003682 chromatin binding GSVIVG01025386001 1170566 1183851 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with chromatin, the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase. IEA GO:0003682 chromatin binding GSVIVG01035371001 851697 855195 GSVIVG01017955001 5060181 5063457 GSVIVG01019474001 932377 932805 GSVIVG01038233001 24525591 24528834 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01038233001 24525591 24528834 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01038233001 24525591 24528834 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01038233001 24525591 24528834 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01038233001 24525591 24528834 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01038233001 24525591 24528834 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01038233001 24525591 24528834 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01038233001 24525591 24528834 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01038233001 24525591 24528834 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01038233001 24525591 24528834 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01038233001 24525591 24528834 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01038233001 24525591 24528834 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01038233001 24525591 24528834 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01038233001 24525591 24528834 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01038233001 24525591 24528834 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01038233001 24525591 24528834 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01038233001 24525591 24528834 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01038233001 24525591 24528834 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01038233001 24525591 24528834 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01038233001 24525591 24528834 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01038233001 24525591 24528834 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01030332001 8762044 8762789 GSVIVG01006122001 41872171 41872492 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01006122001 41872171 41872492 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01007961001 7139023 7151201 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01007961001 7139023 7151201 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01007961001 7139023 7151201 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01007961001 7139023 7151201 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01012018001 2147401 2148062 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012018001 2147401 2148062 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01012018001 2147401 2148062 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01037526001 12236160 12253170 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01037526001 12236160 12253170 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01021170001 2133388 2135565 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01019857001 3880218 3885160 GSVIVG01010218001 17760880 17762318 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01010218001 17760880 17762318 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01021122001 1642651 1657258 Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01021122001 1642651 1657258 Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01008697001 1281190 1291984 GSVIVG01023399001 12566392 12567979 GSVIVG01015599001 5423943 5427320 GSVIVG01025986001 26257299 26262353 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018823001 19585929 19587433 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the reaction: pectin + n H2O = n methanol + pectate. IEA GO:0030599 pectinesterase activity GSVIVG01027024001 18506593 18510377 GSVIVG01008078001 6000439 6005998 GSVIVG01013502001 1950583 1952225 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01013502001 1950583 1952225 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01014474001 4233865 4234385 Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01025292001 2401351 2401566 GSVIVG01028522001 9125195 9126128 GSVIVG01019930001 4535846 4538927 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008332001 3169137 3179314 GSVIVG01016982001 3156804 3157341 GSVIVG01012025001 2099999 2101337 GSVIVG01029543001 21793268 21804701 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01038689001 20987085 20993301 GSVIVG01010935001 15402435 15402649 GSVIVG01033109001 25784052 25789602 GSVIVG01014363001 3022709 3035710 GSVIVG01009208001 6249098 6255464 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01034840001 22487871 22493242 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01029995001 8785149 8787173 GSVIVG01013903001 6600794 6601914 GSVIVG01032373001 26787437 26792127 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01011747001 4585734 4591099 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01015203001 1800945 1807844 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015203001 1800945 1807844 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01015203001 1800945 1807844 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01015203001 1800945 1807844 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01036671001 20059866 20062297 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01025898001 27402303 27404654 GSVIVG01013917001 6726119 6741140 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01013917001 6726119 6741140 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01007686001 10400980 10403578 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007686001 10400980 10403578 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007686001 10400980 10403578 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007686001 10400980 10403578 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01007686001 10400980 10403578 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01007686001 10400980 10403578 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01007686001 10400980 10403578 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01007686001 10400980 10403578 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01007686001 10400980 10403578 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01007686001 10400980 10403578 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01007686001 10400980 10403578 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01007686001 10400980 10403578 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01012453001 1055094 1113949 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01012453001 1055094 1113949 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01033884001 17031292 17031948 GSVIVG01019391001 254142 263652 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019391001 254142 263652 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019391001 254142 263652 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019391001 254142 263652 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019391001 254142 263652 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019391001 254142 263652 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019391001 254142 263652 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01019391001 254142 263652 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01019391001 254142 263652 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01019391001 254142 263652 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01019391001 254142 263652 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01019391001 254142 263652 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01019391001 254142 263652 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01019391001 254142 263652 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01019391001 254142 263652 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01019391001 254142 263652 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01019391001 254142 263652 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01019391001 254142 263652 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01033939001 16570231 16576567 GSVIVG01029712001 13526679 13529615 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030051001 9196237 9205528 GSVIVG01013310001 11660474 11664852 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013310001 11660474 11664852 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024009001 1764623 1768176 GSVIVG01036853001 18774893 18778611 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01036853001 18774893 18778611 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01036853001 18774893 18778611 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01036853001 18774893 18778611 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009330001 7484813 7485994 GSVIVG01016315001 5189295 5202879 GSVIVG01006632001 27159362 27161311 GSVIVG01017711001 2845585 2846772 The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01015098001 1033052 1035909 GO:0006383 transcription from RNA polymerase III promoter The synthesis of RNA from a DNA template by RNA polymerase III (Pol III), originating at a Pol III-specific promoter. IEA GO:0005666 DNA-directed RNA polymerase III complex RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01015098001 1033052 1035909 GO:0006383 transcription from RNA polymerase III promoter The synthesis of RNA from a DNA template by RNA polymerase III (Pol III), originating at a Pol III-specific promoter. IEA GO:0005666 DNA-directed RNA polymerase III complex RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01036475001 22528454 22533516 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA GSVIVG01001041001 6771074 6778491 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01001041001 6771074 6778491 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with ribosomal RNA. IEA GO:0019843 rRNA binding GSVIVG01003946001 13945740 13951172 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0033588 Elongator holoenzyme complex A heterohexameric protein complex that is involved in tRNA modification, and exerts indirect effects on transcriptional elongation and exocytosis. The complex can associate physically with hyperphosphorylated RNA polymerase II; it contains two discrete heterotrimeric subcomplexes. IEA Interacting selectively and non-covalently with damaged DNA. IEA GO:0003684 damaged DNA binding GSVIVG01003946001 13945740 13951172 GO:0006357 regulation of transcription from RNA polymerase II promoter Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. IEA GO:0033588 Elongator holoenzyme complex A heterohexameric protein complex that is involved in tRNA modification, and exerts indirect effects on transcriptional elongation and exocytosis. The complex can associate physically with hyperphosphorylated RNA polymerase II; it contains two discrete heterotrimeric subcomplexes. IEA Interacting selectively and non-covalently with damaged DNA. IEA GO:0003684 damaged DNA binding GSVIVG01003946001 13945740 13951172 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0033588 Elongator holoenzyme complex A heterohexameric protein complex that is involved in tRNA modification, and exerts indirect effects on transcriptional elongation and exocytosis. The complex can associate physically with hyperphosphorylated RNA polymerase II; it contains two discrete heterotrimeric subcomplexes. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003946001 13945740 13951172 GO:0006357 regulation of transcription from RNA polymerase II promoter Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. IEA GO:0033588 Elongator holoenzyme complex A heterohexameric protein complex that is involved in tRNA modification, and exerts indirect effects on transcriptional elongation and exocytosis. The complex can associate physically with hyperphosphorylated RNA polymerase II; it contains two discrete heterotrimeric subcomplexes. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029254001 17958940 17965878 Interacting selectively and non-covalently with single-stranded DNA. IEA GO:0003697 single-stranded DNA binding GSVIVG01008218001 4528656 4537653 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01008218001 4528656 4537653 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01008218001 4528656 4537653 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01008218001 4528656 4537653 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008218001 4528656 4537653 Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01008218001 4528656 4537653 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01037252001 16895096 16897464 GSVIVG01035563001 2331224 2332505 GO:0006413 translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. IEA Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. IEA GO:0003743 translation initiation factor activity GSVIVG01019510001 1219225 1228009 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019510001 1219225 1228009 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019510001 1219225 1228009 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019510001 1219225 1228009 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019510001 1219225 1228009 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01019510001 1219225 1228009 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01006729001 27807025 27811789 GSVIVG01031001001 20653101 20668544 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01022001001 4483691 4485868 GSVIVG01033632001 19088019 19098996 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01033632001 19088019 19098996 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01033632001 19088019 19098996 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01033632001 19088019 19098996 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01035287001 55349 55990 GSVIVG01013302001 1096353 1096445 GSVIVG01035106001 1507786 1515522 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: UDP-glucose + D-fructose = UDP + sucrose. IEA GO:0016157 sucrose synthase activity GSVIVG01009605001 9816439 9818721 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01009605001 9816439 9818721 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01009605001 9816439 9818721 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01009605001 9816439 9818721 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01007532001 12556745 12558304 GSVIVG01002339001 34205245 34206672 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01012781001 23341316 23345695 GSVIVG01007688001 10369943 10373977 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01007688001 10369943 10373977 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01007688001 10369943 10373977 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01007688001 10369943 10373977 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01007688001 10369943 10373977 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011027001 2103477 2105399 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01017708001 2818841 2819414 GSVIVG01003120001 7437124 7440814 GSVIVG01033193001 9395799 9397432 GSVIVG01022084001 16460968 16469948 GSVIVG01029021001 10803639 10807112 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01010603001 16121438 16122777 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with a lipid. IEA GO:0008289 lipid binding GSVIVG01010603001 16121438 16122777 GO:0006869 lipid transport The directed movement of lipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Interacting selectively and non-covalently with a lipid. IEA GO:0008289 lipid binding GSVIVG01001237001 1790453 1791004 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01020573001 4181331 4181660 GSVIVG01016746001 873126 875041 GSVIVG01014655001 8237520 8237662 GSVIVG01010379001 20003391 20003813 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01023414001 12382371 12384926 GO:0006801 superoxide metabolic process The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01023414001 12382371 12384926 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01012082001 1582803 1583649 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The action of a molecule that contributes to the structural integrity of a cell wall. IEA GO:0005199 structural constituent of cell wall GSVIVG01027201001 18412936 18423631 GSVIVG01020551001 4458311 4466998 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01020551001 4458311 4466998 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01012391001 364934 365686 GSVIVG01033804001 17659640 17669419 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01033804001 17659640 17669419 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033804001 17659640 17669419 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01033804001 17659640 17669419 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01035784001 4258543 4265236 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01035784001 4258543 4265236 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01035784001 4258543 4265236 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01035784001 4258543 4265236 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035784001 4258543 4265236 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01035784001 4258543 4265236 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01005522001 40563613 40563855 GSVIVG01017853001 4036866 4054035 GSVIVG01034457001 20989273 20993698 GSVIVG01031518001 17713455 17715662 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01031518001 17713455 17715662 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01015573001 5096002 5097491 The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01022702001 15294746 15296828 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. IEA GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GSVIVG01004473001 38740879 38741090 GSVIVG01018876001 19040070 19040849 GSVIVG01007244001 31060910 31068285 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007244001 31060910 31068285 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007244001 31060910 31068285 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01007244001 31060910 31068285 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01007244001 31060910 31068285 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01007244001 31060910 31068285 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01007244001 31060910 31068285 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01007244001 31060910 31068285 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01028126001 4026639 4028453 GSVIVG01024766001 7123671 7125579 GSVIVG01016453001 3754406 3766396 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01034940001 258168 261964 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01034940001 258168 261964 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01015277001 2343156 2345666 Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum. IEA GO:0003993 acid phosphatase activity GSVIVG01025684001 12963008 12966267 GSVIVG01009417001 8190899 8193301 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01009417001 8190899 8193301 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01009417001 8190899 8193301 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01009417001 8190899 8193301 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009417001 8190899 8193301 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01013366001 932504 935155 GSVIVG01031761001 4170184 4173696 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01038593001 21624565 21629330 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01029664001 12672698 12674161 GSVIVG01020712001 2837402 2887099 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01020712001 2837402 2887099 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01020712001 2837402 2887099 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01020712001 2837402 2887099 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029380001 15811509 15812357 GSVIVG01015211001 1856283 1862377 GO:0006544 glycine metabolic process The chemical reactions and pathways involving glycine, aminoethanoic acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015211001 1856283 1862377 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015211001 1856283 1862377 GO:0006544 glycine metabolic process The chemical reactions and pathways involving glycine, aminoethanoic acid. IEA Catalysis of the reaction: glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + CO2. IEA GO:0004375 glycine dehydrogenase (decarboxylating) activity GSVIVG01015211001 1856283 1862377 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + CO2. IEA GO:0004375 glycine dehydrogenase (decarboxylating) activity GSVIVG01015211001 1856283 1862377 GO:0006544 glycine metabolic process The chemical reactions and pathways involving glycine, aminoethanoic acid. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01015211001 1856283 1862377 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01030457001 5726547 5727884 GSVIVG01012752001 24020085 24020682 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01012752001 24020085 24020682 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01020801001 1792478 1822284 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01032911001 24045544 24048408 GSVIVG01021098001 1443071 1444059 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01021098001 1443071 1444059 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01018648001 11683724 11687206 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01018648001 11683724 11687206 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01018648001 11683724 11687206 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01018648001 11683724 11687206 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01018648001 11683724 11687206 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01018648001 11683724 11687206 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01033195001 9409805 9411286 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01033195001 9409805 9411286 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01014971001 13278717 13280843 GSVIVG01008253001 4062834 4068708 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GSVIVG01028941001 17206674 17208766 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01028941001 17206674 17208766 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01028941001 17206674 17208766 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01028941001 17206674 17208766 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01028941001 17206674 17208766 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01028941001 17206674 17208766 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01028941001 17206674 17208766 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01028941001 17206674 17208766 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01028941001 17206674 17208766 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01028941001 17206674 17208766 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01028941001 17206674 17208766 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01028941001 17206674 17208766 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01028941001 17206674 17208766 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01028941001 17206674 17208766 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01028941001 17206674 17208766 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01028941001 17206674 17208766 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01028941001 17206674 17208766 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01028941001 17206674 17208766 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01028941001 17206674 17208766 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01028941001 17206674 17208766 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01028941001 17206674 17208766 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01028941001 17206674 17208766 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01028941001 17206674 17208766 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01028941001 17206674 17208766 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01028941001 17206674 17208766 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01028941001 17206674 17208766 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01028941001 17206674 17208766 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01035302001 191773 194565 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01029899001 1155840 1204553 GSVIVG01018517001 13956039 13962627 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0000015 phosphopyruvate hydratase complex A multimeric enzyme complex, usually a dimer or an octamer, that catalyzes the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate and water. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01018517001 13956039 13962627 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0000015 phosphopyruvate hydratase complex A multimeric enzyme complex, usually a dimer or an octamer, that catalyzes the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate and water. IEA Catalysis of the reaction: 2-phospho-D-glycerate = phosphoenolpyruvate + H2O. IEA GO:0004634 phosphopyruvate hydratase activity GSVIVG01010044001 13803711 13805352 GSVIVG01011877001 3356428 3358218 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA GSVIVG01021318001 3966988 3973377 GSVIVG01016986001 3186179 3187665 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01019752001 2972655 2976285 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01019752001 2972655 2976285 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01019752001 2972655 2976285 GO:0006436 tryptophanyl-tRNA aminoacylation The process of coupling tryptophan to tryptophanyl-tRNA, catalyzed by tryptophanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01019752001 2972655 2976285 GO:0006437 tyrosyl-tRNA aminoacylation The process of coupling tyrosine to tyrosyl-tRNA, catalyzed by tyrosyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01019752001 2972655 2976285 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01019752001 2972655 2976285 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01019752001 2972655 2976285 GO:0006436 tryptophanyl-tRNA aminoacylation The process of coupling tryptophan to tryptophanyl-tRNA, catalyzed by tryptophanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01019752001 2972655 2976285 GO:0006437 tyrosyl-tRNA aminoacylation The process of coupling tyrosine to tyrosyl-tRNA, catalyzed by tyrosyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01019752001 2972655 2976285 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophanyl-tRNA(Trp). IEA GO:0004830 tryptophan-tRNA ligase activity GSVIVG01019752001 2972655 2976285 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophanyl-tRNA(Trp). IEA GO:0004830 tryptophan-tRNA ligase activity GSVIVG01019752001 2972655 2976285 GO:0006436 tryptophanyl-tRNA aminoacylation The process of coupling tryptophan to tryptophanyl-tRNA, catalyzed by tryptophanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophanyl-tRNA(Trp). IEA GO:0004830 tryptophan-tRNA ligase activity GSVIVG01019752001 2972655 2976285 GO:0006437 tyrosyl-tRNA aminoacylation The process of coupling tyrosine to tyrosyl-tRNA, catalyzed by tyrosyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophanyl-tRNA(Trp). IEA GO:0004830 tryptophan-tRNA ligase activity GSVIVG01019752001 2972655 2976285 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr). IEA GO:0004831 tyrosine-tRNA ligase activity GSVIVG01019752001 2972655 2976285 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr). IEA GO:0004831 tyrosine-tRNA ligase activity GSVIVG01019752001 2972655 2976285 GO:0006436 tryptophanyl-tRNA aminoacylation The process of coupling tryptophan to tryptophanyl-tRNA, catalyzed by tryptophanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr). IEA GO:0004831 tyrosine-tRNA ligase activity GSVIVG01019752001 2972655 2976285 GO:0006437 tyrosyl-tRNA aminoacylation The process of coupling tyrosine to tyrosyl-tRNA, catalyzed by tyrosyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr). IEA GO:0004831 tyrosine-tRNA ligase activity GSVIVG01019752001 2972655 2976285 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019752001 2972655 2976285 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019752001 2972655 2976285 GO:0006436 tryptophanyl-tRNA aminoacylation The process of coupling tryptophan to tryptophanyl-tRNA, catalyzed by tryptophanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019752001 2972655 2976285 GO:0006437 tyrosyl-tRNA aminoacylation The process of coupling tyrosine to tyrosyl-tRNA, catalyzed by tyrosyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01004266001 37830402 37835081 GSVIVG01017747001 3108717 3109277 GSVIVG01015414001 3399858 3418001 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01015414001 3399858 3418001 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01015414001 3399858 3418001 GO:0008272 sulfate transport The directed movement of sulfate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01015414001 3399858 3418001 GO:0008272 sulfate transport The directed movement of sulfate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01015414001 3399858 3418001 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01015414001 3399858 3418001 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01015414001 3399858 3418001 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01015414001 3399858 3418001 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01015414001 3399858 3418001 GO:0008272 sulfate transport The directed movement of sulfate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01015414001 3399858 3418001 GO:0008272 sulfate transport The directed movement of sulfate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01015414001 3399858 3418001 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01015414001 3399858 3418001 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01028990001 10177414 10289083 GO:0016459 myosin complex A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. IEA Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate. IEA GO:0003774 motor activity GSVIVG01028990001 10177414 10289083 GO:0016459 myosin complex A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01028990001 10177414 10289083 GO:0016459 myosin complex A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028990001 10177414 10289083 GO:0016459 myosin complex A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. IEA Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits. IEA GO:0051015 actin filament binding GSVIVG01028250001 4938227 4945454 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01028250001 4938227 4945454 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01028250001 4938227 4945454 GO:0006433 prolyl-tRNA aminoacylation The process of coupling proline to prolyl-tRNA, catalyzed by prolyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01028250001 4938227 4945454 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01028250001 4938227 4945454 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01028250001 4938227 4945454 GO:0006433 prolyl-tRNA aminoacylation The process of coupling proline to prolyl-tRNA, catalyzed by prolyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01028250001 4938227 4945454 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro). IEA GO:0004827 proline-tRNA ligase activity GSVIVG01028250001 4938227 4945454 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro). IEA GO:0004827 proline-tRNA ligase activity GSVIVG01028250001 4938227 4945454 GO:0006433 prolyl-tRNA aminoacylation The process of coupling proline to prolyl-tRNA, catalyzed by prolyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro). IEA GO:0004827 proline-tRNA ligase activity GSVIVG01028250001 4938227 4945454 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028250001 4938227 4945454 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028250001 4938227 4945454 GO:0006433 prolyl-tRNA aminoacylation The process of coupling proline to prolyl-tRNA, catalyzed by prolyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015698001 15796530 15797120 GSVIVG01009226001 6430671 6439022 GO:0006544 glycine metabolic process The chemical reactions and pathways involving glycine, aminoethanoic acid. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009226001 6430671 6439022 GO:0006563 L-serine metabolic process The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009226001 6430671 6439022 GO:0006544 glycine metabolic process The chemical reactions and pathways involving glycine, aminoethanoic acid. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine. IEA GO:0004372 glycine hydroxymethyltransferase activity GSVIVG01009226001 6430671 6439022 GO:0006563 L-serine metabolic process The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine. IEA GO:0004372 glycine hydroxymethyltransferase activity GSVIVG01009226001 6430671 6439022 GO:0006544 glycine metabolic process The chemical reactions and pathways involving glycine, aminoethanoic acid. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01009226001 6430671 6439022 GO:0006563 L-serine metabolic process The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01023881001 2749512 2751111 GSVIVG01001495001 5150832 5151144 GSVIVG01019038001 17484664 17489709 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01019038001 17484664 17489709 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01019038001 17484664 17489709 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01019038001 17484664 17489709 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01019038001 17484664 17489709 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01019038001 17484664 17489709 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01019038001 17484664 17489709 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019038001 17484664 17489709 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025685001 12956454 12961193 GSVIVG01008874001 2950360 2959283 GSVIVG01023946001 2253367 2255550 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0031227 intrinsic to endoplasmic reticulum membrane Located in the endoplasmic reticulum membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01023946001 2253367 2255550 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0031227 intrinsic to endoplasmic reticulum membrane Located in the endoplasmic reticulum membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01023946001 2253367 2255550 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0031227 intrinsic to endoplasmic reticulum membrane Located in the endoplasmic reticulum membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01008976001 3979749 3980165 GSVIVG01025848001 11231302 11255629 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025848001 11231302 11255629 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01020565001 4271777 4277320 GSVIVG01007987001 6888373 6890086 GO:0009306 protein secretion The controlled release of proteins from a cell or group of cells. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01007987001 6888373 6890086 GO:0009306 protein secretion The controlled release of proteins from a cell or group of cells. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01007987001 6888373 6890086 GO:0009306 protein secretion The controlled release of proteins from a cell or group of cells. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01007987001 6888373 6890086 GO:0009664 plant-type cell wall organization A process that results in the assembly and arrangement of constituent parts of the cellulose and pectin-containing cell wall, or in the disassembly of the cellulose and pectin-containing cell wall. This process is carried out at the cellular level. An example of this process is found in Arabidopsis thaliana. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01007987001 6888373 6890086 GO:0009664 plant-type cell wall organization A process that results in the assembly and arrangement of constituent parts of the cellulose and pectin-containing cell wall, or in the disassembly of the cellulose and pectin-containing cell wall. This process is carried out at the cellular level. An example of this process is found in Arabidopsis thaliana. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01007987001 6888373 6890086 GO:0009664 plant-type cell wall organization A process that results in the assembly and arrangement of constituent parts of the cellulose and pectin-containing cell wall, or in the disassembly of the cellulose and pectin-containing cell wall. This process is carried out at the cellular level. An example of this process is found in Arabidopsis thaliana. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01007665001 10708717 10715399 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01007665001 10708717 10715399 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01007665001 10708717 10715399 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007665001 10708717 10715399 Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01018002001 5399371 5399889 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. IEA GO:0008080 N-acetyltransferase activity GSVIVG01008566001 839245 840576 GSVIVG01008192001 4806535 4817448 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: 3-alpha(S)-strictosidine = tryptamine + secologanin. IEA GO:0016844 strictosidine synthase activity GSVIVG01036103001 20673474 20674440 GSVIVG01017663001 2451346 2459325 GO:0006614 SRP-dependent cotranslational protein targeting to membrane The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. IEA GO:0048500 signal recognition particle A complex of protein and RNA which facilitates translocation of proteins across membranes. IEA Interacting selectively and non-covalently with 7S RNA, the RNA component of the signal recognition particle (SRP). IEA GO:0008312 7S RNA binding GSVIVG01038659001 21152035 21155500 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01038659001 21152035 21155500 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01038659001 21152035 21155500 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01038659001 21152035 21155500 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01017341001 6884617 6886518 GSVIVG01037905001 6479125 6503918 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01037905001 6479125 6503918 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with damaged DNA. IEA GO:0003684 damaged DNA binding GSVIVG01037905001 6479125 6503918 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and primer. IEA GO:0003887 DNA-directed DNA polymerase activity GSVIVG01037905001 6479125 6503918 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the transfer of a nucleotidyl group to a reactant. IEA GO:0016779 nucleotidyltransferase activity GSVIVG01020100001 10323462 10348110 GSVIVG01018504001 14230062 14230310 GSVIVG01016641001 2221348 2235986 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01016641001 2221348 2235986 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01016641001 2221348 2235986 GO:0008272 sulfate transport The directed movement of sulfate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01016641001 2221348 2235986 GO:0008272 sulfate transport The directed movement of sulfate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01016641001 2221348 2235986 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01016641001 2221348 2235986 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01016641001 2221348 2235986 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01016641001 2221348 2235986 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01016641001 2221348 2235986 GO:0008272 sulfate transport The directed movement of sulfate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01016641001 2221348 2235986 GO:0008272 sulfate transport The directed movement of sulfate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01016641001 2221348 2235986 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01016641001 2221348 2235986 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01023085001 15525013 15535778 GSVIVG01035013001 894704 896132 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035013001 894704 896132 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01035013001 894704 896132 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01005280001 418075 431333 GSVIVG01001358001 23934190 23944147 GO:0006099 tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. IEA Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA, where the acetyl group is added to the si-face of oxaloacetate; acetyl-CoA thus provides the two carbon atoms of the pro-S carboxymethyl group. IEA GO:0004108 citrate (Si)-synthase activity GSVIVG01001358001 23934190 23944147 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA, where the acetyl group is added to the si-face of oxaloacetate; acetyl-CoA thus provides the two carbon atoms of the pro-S carboxymethyl group. IEA GO:0004108 citrate (Si)-synthase activity GSVIVG01001358001 23934190 23944147 GO:0006099 tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. IEA Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor), with the acyl group being converted into alkyl on transfer. IEA GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer GSVIVG01001358001 23934190 23944147 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor), with the acyl group being converted into alkyl on transfer. IEA GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer GSVIVG01009631001 10051706 10052113 GSVIVG01025182001 3628781 3636774 GO:0008299 isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01025182001 3628781 3636774 GO:0016114 terpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01025182001 3628781 3636774 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01025182001 3628781 3636774 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01025182001 3628781 3636774 GO:0008299 isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. IEA Catalysis of the reaction: (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + protein-disulfide = 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + protein-dithiol. Note that (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate is an alternative way of naming 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. IEA GO:0046429 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity GSVIVG01025182001 3628781 3636774 GO:0016114 terpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure. IEA Catalysis of the reaction: (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + protein-disulfide = 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + protein-dithiol. Note that (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate is an alternative way of naming 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. IEA GO:0046429 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity GSVIVG01025182001 3628781 3636774 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of the reaction: (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + protein-disulfide = 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + protein-dithiol. Note that (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate is an alternative way of naming 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. IEA GO:0046429 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity GSVIVG01025182001 3628781 3636774 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + protein-disulfide = 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + protein-dithiol. Note that (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate is an alternative way of naming 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. IEA GO:0046429 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity GSVIVG01005193001 19022784 19024305 GSVIVG01024004001 1795806 1801225 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA GSVIVG01024004001 1795806 1801225 GO:0006888 ER to Golgi vesicle-mediated transport The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA GSVIVG01017530001 9989521 9990412 GSVIVG01015167001 1506369 1508546 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015167001 1506369 1508546 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016457001 3712203 3715174 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016457001 3712203 3715174 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016457001 3712203 3715174 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016457001 3712203 3715174 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016457001 3712203 3715174 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016457001 3712203 3715174 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01016457001 3712203 3715174 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01016457001 3712203 3715174 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01016457001 3712203 3715174 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01016457001 3712203 3715174 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01016457001 3712203 3715174 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016457001 3712203 3715174 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016457001 3712203 3715174 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016457001 3712203 3715174 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016457001 3712203 3715174 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016457001 3712203 3715174 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01016457001 3712203 3715174 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01016457001 3712203 3715174 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01016457001 3712203 3715174 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01016457001 3712203 3715174 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01035183001 12989959 12990599 GSVIVG01027115001 17739948 17740139 GSVIVG01022040001 3889464 3890312 GSVIVG01025405001 1031983 1035572 GSVIVG01023244001 20691724 20691999 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023244001 20691724 20691999 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023244001 20691724 20691999 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01023244001 20691724 20691999 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01027770001 7542707 7543099 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01027770001 7542707 7543099 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01027770001 7542707 7543099 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01027770001 7542707 7543099 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01027770001 7542707 7543099 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01027770001 7542707 7543099 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01027462001 16551973 16563829 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01027462001 16551973 16563829 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01027462001 16551973 16563829 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01027462001 16551973 16563829 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01027462001 16551973 16563829 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt. IEA GO:0004525 ribonuclease III activity GSVIVG01027462001 16551973 16563829 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027462001 16551973 16563829 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01027462001 16551973 16563829 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01025360001 1538469 1545875 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01025360001 1538469 1545875 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01025360001 1538469 1545875 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01016593001 2556129 2559260 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01032856001 195175 213805 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion. IEA GO:0005484 SNAP receptor activity GSVIVG01032856001 195175 213805 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion. IEA GO:0005484 SNAP receptor activity GSVIVG01032856001 195175 213805 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032856001 195175 213805 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013681001 2534502 2536877 GSVIVG01026572001 21558561 21559069 GSVIVG01017610001 1975299 1976766 GSVIVG01013695001 2728393 2732208 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01013695001 2728393 2732208 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01013695001 2728393 2732208 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01013695001 2728393 2732208 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01013695001 2728393 2732208 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01013695001 2728393 2732208 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01013695001 2728393 2732208 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01013695001 2728393 2732208 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01020785001 2013607 2033036 GSVIVG01003791001 12751819 12756412 GSVIVG01008593001 563632 567370 GSVIVG01012775001 23440764 23448827 GSVIVG01027218001 18033658 18037957 GSVIVG01026439001 23624397 23627302 GSVIVG01007662001 10745402 10748530 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01007662001 10745402 10748530 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01007662001 10745402 10748530 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01007662001 10745402 10748530 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01007662001 10745402 10748530 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01007662001 10745402 10748530 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01007662001 10745402 10748530 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01007662001 10745402 10748530 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01008995001 4130710 4134329 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008995001 4130710 4134329 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01008995001 4130710 4134329 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01027315001 16736489 16763685 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01027315001 16736489 16763685 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01027315001 16736489 16763685 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. IEA GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity GSVIVG01027315001 16736489 16763685 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. IEA GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity GSVIVG01027315001 16736489 16763685 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027315001 16736489 16763685 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025215001 3220942 3232678 GSVIVG01003998001 14155112 14159158 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003998001 14155112 14159158 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01003998001 14155112 14159158 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01025743001 12311655 12317530 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. IEA GO:0004725 protein tyrosine phosphatase activity GSVIVG01025743001 12311655 12317530 GO:0016311 dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. IEA Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. IEA GO:0004725 protein tyrosine phosphatase activity GSVIVG01025743001 12311655 12317530 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA Catalysis of the reaction: protein serine/threonine/tyrosine phosphate + H2O = protein serine/threonine/tyrosine + phosphate. IEA GO:0008138 protein tyrosine/serine/threonine phosphatase activity GSVIVG01025743001 12311655 12317530 GO:0016311 dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. IEA Catalysis of the reaction: protein serine/threonine/tyrosine phosphate + H2O = protein serine/threonine/tyrosine + phosphate. IEA GO:0008138 protein tyrosine/serine/threonine phosphatase activity GSVIVG01025743001 12311655 12317530 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. IEA GO:0016791 phosphatase activity GSVIVG01025743001 12311655 12317530 GO:0016311 dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. IEA Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. IEA GO:0016791 phosphatase activity GSVIVG01034780001 21347599 21439377 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01034780001 21347599 21439377 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01034780001 21347599 21439377 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01034780001 21347599 21439377 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with double-stranded RNA. IEA GO:0003725 double-stranded RNA binding GSVIVG01034780001 21347599 21439377 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01034780001 21347599 21439377 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034780001 21347599 21439377 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01034780001 21347599 21439377 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01011044001 2003271 2011462 GSVIVG01033135001 8218686 8218892 GSVIVG01010873001 16564531 16576521 GO:0008202 steroid metabolic process The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. IEA GSVIVG01012406001 518343 518697 GSVIVG01006103001 41522911 41524577 GSVIVG01034611001 14460743 14479142 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01021607001 7926732 7982427 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cation(out) + Cl-(out) = cation(in) + Cl-(in). IEA GO:0015377 cation:chloride symporter activity GSVIVG01021607001 7926732 7982427 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cation(out) + Cl-(out) = cation(in) + Cl-(in). IEA GO:0015377 cation:chloride symporter activity GSVIVG01021607001 7926732 7982427 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cation(out) + Cl-(out) = cation(in) + Cl-(in). IEA GO:0015377 cation:chloride symporter activity GSVIVG01021607001 7926732 7982427 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cation(out) + Cl-(out) = cation(in) + Cl-(in). IEA GO:0015377 cation:chloride symporter activity GSVIVG01021607001 7926732 7982427 GO:0006821 chloride transport The directed movement of chloride into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cation(out) + Cl-(out) = cation(in) + Cl-(in). IEA GO:0015377 cation:chloride symporter activity GSVIVG01021607001 7926732 7982427 GO:0006821 chloride transport The directed movement of chloride into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cation(out) + Cl-(out) = cation(in) + Cl-(in). IEA GO:0015377 cation:chloride symporter activity GSVIVG01021607001 7926732 7982427 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cation(out) + Cl-(out) = cation(in) + Cl-(in). IEA GO:0015377 cation:chloride symporter activity GSVIVG01021607001 7926732 7982427 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cation(out) + Cl-(out) = cation(in) + Cl-(in). IEA GO:0015377 cation:chloride symporter activity GSVIVG01031157001 1641514 1644695 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01038709001 20740371 20751493 GSVIVG01025716001 12697420 12704882 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01025716001 12697420 12704882 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01025716001 12697420 12704882 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01025716001 12697420 12704882 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019767001 3144644 3153646 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0008021 synaptic vesicle A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and is secreted these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01019767001 3144644 3153646 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01022679001 14619391 14622613 GSVIVG01010208001 17455712 17470659 GSVIVG01032937001 24364742 24438092 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017840001 3943020 3944862 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01018830001 19496679 19502630 GSVIVG01008273001 3747801 3760737 GSVIVG01019003001 17908397 17908600 GSVIVG01000058001 3138017 3152738 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01000058001 3138017 3152738 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01000058001 3138017 3152738 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01000058001 3138017 3152738 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000058001 3138017 3152738 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000058001 3138017 3152738 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with manganese (Mn) ions. IEA GO:0030145 manganese ion binding GSVIVG01000058001 3138017 3152738 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Functions in the storage of nutritious substrates. IEA GO:0045735 nutrient reservoir activity GSVIVG01036071001 21041266 21046146 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01022493001 3843222 3855313 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01026995001 18713020 18728449 GSVIVG01018985001 18064983 18073658 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. IEA GO:0003743 translation initiation factor activity GSVIVG01018985001 18064983 18073658 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. IEA GO:0003743 translation initiation factor activity GSVIVG01018985001 18064983 18073658 GO:0006413 translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. IEA Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. IEA GO:0003743 translation initiation factor activity GSVIVG01018985001 18064983 18073658 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018985001 18064983 18073658 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018985001 18064983 18073658 GO:0006413 translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018985001 18064983 18073658 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01018985001 18064983 18073658 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01018985001 18064983 18073658 GO:0006413 translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01018985001 18064983 18073658 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01018985001 18064983 18073658 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01018985001 18064983 18073658 GO:0006413 translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01036050001 21369602 21369664 GSVIVG01018811001 19662096 19665583 GSVIVG01012637001 245231 250494 GSVIVG01020519001 4883037 4885123 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01027123001 17642880 17644150 Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. IEA GO:0008171 O-methyltransferase activity GSVIVG01026582001 21396248 21402234 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01011697001 5030550 5057195 GO:0030833 regulation of actin filament polymerization Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament. IEA GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA GSVIVG01032999001 24979361 24981641 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032999001 24979361 24981641 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032999001 24979361 24981641 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032999001 24979361 24981641 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01032999001 24979361 24981641 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01032999001 24979361 24981641 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01032999001 24979361 24981641 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032999001 24979361 24981641 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032999001 24979361 24981641 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032999001 24979361 24981641 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01032999001 24979361 24981641 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01032999001 24979361 24981641 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01032999001 24979361 24981641 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01032999001 24979361 24981641 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01032999001 24979361 24981641 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01017489001 9343121 9344414 GSVIVG01012364001 52480 53659 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01015063001 799692 801692 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01036818001 17448717 17452527 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01007941001 7317400 7320708 GSVIVG01007390001 927617 936189 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033730001 18284336 18284878 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033730001 18284336 18284878 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01032274001 14360219 14367190 GSVIVG01027333001 16444300 16469682 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01011261001 10217164 10217459 GSVIVG01016375001 4370356 4380625 GO:0006188 IMP biosynthetic process The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016375001 4370356 4380625 GO:0009152 purine ribonucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016375001 4370356 4380625 GO:0006188 IMP biosynthetic process The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate. IEA Catalysis of the reaction: N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP. IEA GO:0004018 N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity GSVIVG01016375001 4370356 4380625 GO:0009152 purine ribonucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. IEA Catalysis of the reaction: N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP. IEA GO:0004018 N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity GSVIVG01012568001 3724133 3724402 GSVIVG01029622001 20592765 20593683 GSVIVG01018913001 18694254 18695869 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01008783001 1996714 1997619 GSVIVG01012631001 221185 222039 GSVIVG01023920001 2475767 2477434 GSVIVG01010544001 16783412 16788434 GSVIVG01023170001 21717879 21725754 GSVIVG01015591001 5295514 5302426 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035728001 3744432 3748057 GSVIVG01024375001 1730687 1738891 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. IEA GO:0008080 N-acetyltransferase activity GSVIVG01002054001 32489828 32490004 GSVIVG01009695001 10529302 10547399 GSVIVG01025035001 5102946 5103128 GSVIVG01032273001 14357147 14359733 GSVIVG01032256001 14090284 14092218 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01032256001 14090284 14092218 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01032256001 14090284 14092218 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01032256001 14090284 14092218 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01016754001 915638 960553 GSVIVG01033646001 18961967 18973771 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024263001 346728 353024 GSVIVG01010222001 17836174 17836991 GSVIVG01021727001 10149936 10152015 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01008634001 249497 249796 GSVIVG01035468001 1498313 1502167 GO:0009690 cytokinin metabolic process The chemical reactions and pathways involving cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035468001 1498313 1502167 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035468001 1498313 1502167 GO:0009690 cytokinin metabolic process The chemical reactions and pathways involving cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01035468001 1498313 1502167 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01035468001 1498313 1502167 GO:0009690 cytokinin metabolic process The chemical reactions and pathways involving cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators. IEA Catalysis of the reaction: N6-dimethylallyladenine + acceptor + H2O = adenine + 3-methylbut-2-enal + reduced electron acceptor. IEA GO:0019139 cytokinin dehydrogenase activity GSVIVG01035468001 1498313 1502167 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: N6-dimethylallyladenine + acceptor + H2O = adenine + 3-methylbut-2-enal + reduced electron acceptor. IEA GO:0019139 cytokinin dehydrogenase activity GSVIVG01035468001 1498313 1502167 GO:0009690 cytokinin metabolic process The chemical reactions and pathways involving cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01035468001 1498313 1502167 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01029761001 14336880 14340989 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029761001 14336880 14340989 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). IEA GO:0016769 transferase activity, transferring nitrogenous groups GSVIVG01029761001 14336880 14340989 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01029402001 16310724 16311002 GSVIVG01010352001 19723131 19728782 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010352001 19723131 19728782 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010352001 19723131 19728782 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010352001 19723131 19728782 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010352001 19723131 19728782 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+. IEA GO:0004316 3-oxoacyl-[acyl-carrier-protein] reductase activity GSVIVG01010352001 19723131 19728782 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+. IEA GO:0004316 3-oxoacyl-[acyl-carrier-protein] reductase activity GSVIVG01010352001 19723131 19728782 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+. IEA GO:0004316 3-oxoacyl-[acyl-carrier-protein] reductase activity GSVIVG01010352001 19723131 19728782 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+. IEA GO:0004316 3-oxoacyl-[acyl-carrier-protein] reductase activity GSVIVG01010352001 19723131 19728782 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01010352001 19723131 19728782 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01010352001 19723131 19728782 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01010352001 19723131 19728782 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01010352001 19723131 19728782 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01010352001 19723131 19728782 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01010352001 19723131 19728782 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01010352001 19723131 19728782 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01010352001 19723131 19728782 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01010352001 19723131 19728782 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01010352001 19723131 19728782 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01010352001 19723131 19728782 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01010352001 19723131 19728782 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01010352001 19723131 19728782 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01010352001 19723131 19728782 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01010352001 19723131 19728782 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01007119001 30162207 30163608 GSVIVG01011077001 1775139 1780557 GSVIVG01025568001 13989808 13990118 GSVIVG01030584001 6902723 6908382 GSVIVG01025056001 4901118 4914987 GSVIVG01023372001 19214728 19215827 GSVIVG01005929001 22784860 22808354 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01012981001 10785023 10786852 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01012981001 10785023 10786852 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01012981001 10785023 10786852 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01012981001 10785023 10786852 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01025319001 2073640 2076496 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017134001 4487070 4489984 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017134001 4487070 4489984 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017134001 4487070 4489984 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017134001 4487070 4489984 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035899001 5478408 5482629 GSVIVG01030008001 8897888 8904130 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01030008001 8897888 8904130 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01030008001 8897888 8904130 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01030008001 8897888 8904130 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01030008001 8897888 8904130 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01008688001 1226991 1228749 GSVIVG01012127001 1209657 1211146 GSVIVG01027827001 8239471 8240265 GSVIVG01021233001 2817847 2820271 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01021233001 2817847 2820271 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01021233001 2817847 2820271 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01021233001 2817847 2820271 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01021233001 2817847 2820271 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01021233001 2817847 2820271 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01021233001 2817847 2820271 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01021233001 2817847 2820271 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01021233001 2817847 2820271 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021233001 2817847 2820271 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034653001 13246255 13247340 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01034653001 13246255 13247340 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01029725001 13773898 13787172 GSVIVG01021725001 10101548 10104421 GSVIVG01026944001 19192581 19196103 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01026944001 19192581 19196103 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01026944001 19192581 19196103 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01026944001 19192581 19196103 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01020677001 3179406 3188435 GO:0008380 RNA splicing The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA. IEA GSVIVG01005275001 20132897 20133916 GSVIVG01011485001 29984790 29985875 GSVIVG01032260001 14173659 14180606 GSVIVG01017879001 4243860 4260802 GSVIVG01007452001 32009438 32011829 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA GSVIVG01007452001 32009438 32011829 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GSVIVG01014795001 9879170 9882786 GSVIVG01000046001 3057711 3061332 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01014286001 2309056 2317229 GO:0006519 cellular amino acid and derivative metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01014286001 2309056 2317229 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01014286001 2309056 2317229 GO:0006519 cellular amino acid and derivative metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells. IEA Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. IEA GO:0008483 transaminase activity GSVIVG01014286001 2309056 2317229 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. IEA GO:0008483 transaminase activity GSVIVG01014286001 2309056 2317229 GO:0006519 cellular amino acid and derivative metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells. IEA Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). IEA GO:0016769 transferase activity, transferring nitrogenous groups GSVIVG01014286001 2309056 2317229 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). IEA GO:0016769 transferase activity, transferring nitrogenous groups GSVIVG01014286001 2309056 2317229 GO:0006519 cellular amino acid and derivative metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells. IEA Catalysis of the reaction: S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + methylthioadenosine. IEA GO:0016847 1-aminocyclopropane-1-carboxylate synthase activity GSVIVG01014286001 2309056 2317229 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + methylthioadenosine. IEA GO:0016847 1-aminocyclopropane-1-carboxylate synthase activity GSVIVG01014286001 2309056 2317229 GO:0006519 cellular amino acid and derivative metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01014286001 2309056 2317229 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01002272001 33821887 33826519 GSVIVG01008005001 6754050 6756019 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01009879001 12032042 12069108 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01009879001 12032042 12069108 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01009879001 12032042 12069108 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end. IEA GO:0004527 exonuclease activity GSVIVG01009879001 12032042 12069108 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end. IEA GO:0004527 exonuclease activity GSVIVG01009879001 12032042 12069108 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of an RNA molecule. IEA GO:0004534 5'-3' exoribonuclease activity GSVIVG01009879001 12032042 12069108 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of an RNA molecule. IEA GO:0004534 5'-3' exoribonuclease activity GSVIVG01009879001 12032042 12069108 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01009879001 12032042 12069108 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01020579001 4097574 4105274 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020579001 4097574 4105274 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01013406001 659973 671731 GO:0008219 cell death A biological process that results in permanent cessation of all vital functions of a cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01012859001 6283976 6300798 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018616001 12183830 12187253 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01018616001 12183830 12187253 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01029012001 10681154 10689366 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017292001 6425289 6427661 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01017292001 6425289 6427661 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01017292001 6425289 6427661 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01017292001 6425289 6427661 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01017713001 2853265 2855466 GSVIVG01003471001 10556405 10563051 GSVIVG01027618001 15025715 15030969 GSVIVG01038626001 21365297 21369283 GSVIVG01013582001 21182891 21183569 GSVIVG01000025001 2901240 2909271 GSVIVG01003674001 12002614 12010166 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01002631001 35507956 35508857 GSVIVG01026121001 24335538 24337256 GSVIVG01006656001 27290568 27293513 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01006656001 27290568 27293513 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01006656001 27290568 27293513 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the elimination of H2S or substituted H2S. IEA GO:0016846 carbon-sulfur lyase activity GSVIVG01006656001 27290568 27293513 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01020754001 2329571 2333082 GO:0005992 trehalose biosynthetic process The chemical reactions and pathways resulting in the formation of trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01020754001 2329571 2333082 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021125001 1685613 1687664 GSVIVG01037588001 10481285 10483494 GSVIVG01013208001 6705375 6707155 GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA GSVIVG01024676001 7872489 7879409 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005850 eukaryotic translation initiation factor 2 complex Complex of three heterogeneous polypeptide chains, that form a ternary complex with initiator methionyl-tRNA and GTP. This ternary complex binds to free 40S subunit, which subsequently binds the 5' end of mRNA. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01024676001 7872489 7879409 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005850 eukaryotic translation initiation factor 2 complex Complex of three heterogeneous polypeptide chains, that form a ternary complex with initiator methionyl-tRNA and GTP. This ternary complex binds to free 40S subunit, which subsequently binds the 5' end of mRNA. IEA Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. IEA GO:0003743 translation initiation factor activity GSVIVG01004123001 15077035 15081363 GSVIVG01003679001 12050451 12059581 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA GSVIVG01029532001 21898510 21899938 GSVIVG01018883001 18974001 19005635 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01018883001 18974001 19005635 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01018883001 18974001 19005635 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01018883001 18974001 19005635 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031279001 635224 644566 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005801 cis-Golgi network The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum. IEA GSVIVG01031279001 635224 644566 GO:0006888 ER to Golgi vesicle-mediated transport The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi. IEA GO:0005801 cis-Golgi network The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum. IEA GSVIVG01027591001 15241141 15243447 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01027591001 15241141 15243447 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01027591001 15241141 15243447 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01027591001 15241141 15243447 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01020208001 9030989 9034081 GSVIVG01034071001 15399444 15404503 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01012063001 1705000 1708666 GO:0006546 glycine catabolic process The chemical reactions and pathways resulting in the breakdown of glycine, aminoethanoic acid. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA GSVIVG01012063001 1705000 1708666 GO:0006546 glycine catabolic process The chemical reactions and pathways resulting in the breakdown of glycine, aminoethanoic acid. IEA GO:0005960 glycine cleavage complex A protein complex that catalyzes the reversible oxidation of glycine. In E. coli, it has four components: dihydrolipoamide dehydrogenase, glycine dehydrogenase (decarboxylating), lipoyl-GcvH-protein and aminomethyltransferase, also known as L, P, H, and T. IEA GSVIVG01024326001 975755 979958 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024326001 975755 979958 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. IEA GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GSVIVG01016242001 6016724 6029354 GO:0006875 cellular metal ion homeostasis Any process involved in the maintenance of an internal steady-state of metal ions at the level of a cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030782001 15998839 16074183 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with damaged DNA. IEA GO:0003684 damaged DNA binding GSVIVG01000639001 20292425 20296562 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000639001 20292425 20296562 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000639001 20292425 20296562 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000639001 20292425 20296562 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017142001 4543340 4546980 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017142001 4543340 4546980 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017142001 4543340 4546980 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017142001 4543340 4546980 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034219001 12954156 12958767 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01034219001 12954156 12958767 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01010953001 2702326 2703002 GSVIVG01014621001 5763311 5766600 GSVIVG01010345001 19670401 19679603 GSVIVG01013216001 6666039 6670079 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01013216001 6666039 6670079 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2-phosphoglycolate + H2O = glycolate + phosphate. IEA GO:0008967 phosphoglycolate phosphatase activity GSVIVG01013216001 6666039 6670079 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01005344001 39841207 39841470 GSVIVG01029588001 21070501 21071837 GSVIVG01020731001 2573990 2575626 Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. IEA GO:0008171 O-methyltransferase activity GSVIVG01024133001 869578 872375 GSVIVG01020293001 21801776 21803332 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020293001 21801776 21803332 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011030001 2090002 2090197 GSVIVG01029962001 2399405 2406048 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01029962001 2399405 2406048 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01000141001 15589316 15590604 GSVIVG01000347001 11803849 11814676 GSVIVG01005991001 23152696 23153033 GSVIVG01030624001 7248181 7258220 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01000213001 16134670 16135849 GSVIVG01013493001 1761645 1813711 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01013493001 1761645 1813711 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01013493001 1761645 1813711 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01013493001 1761645 1813711 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01013493001 1761645 1813711 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01013493001 1761645 1813711 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01036452001 22199883 22206312 GSVIVG01029918001 1471505 1476232 GSVIVG01017233001 5746232 5749074 GSVIVG01000509001 13190069 13190368 GSVIVG01018814001 19652828 19656380 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01018814001 19652828 19656380 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01018814001 19652828 19656380 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01018814001 19652828 19656380 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018814001 19652828 19656380 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015243001 2075004 2075934 Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. IEA GO:0008171 O-methyltransferase activity GSVIVG01022117001 16722078 16724954 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01022117001 16722078 16724954 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01022117001 16722078 16724954 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01022117001 16722078 16724954 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027447001 16666784 16668688 GSVIVG01008945001 3700491 3718099 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Interacting selectively and non-covalently with chromatin, the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase. IEA GO:0003682 chromatin binding GSVIVG01008945001 3700491 3718099 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with chromatin, the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase. IEA GO:0003682 chromatin binding GSVIVG01008945001 3700491 3718099 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with chromatin, the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase. IEA GO:0003682 chromatin binding GSVIVG01008945001 3700491 3718099 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Interacting selectively and non-covalently with chromatin, the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase. IEA GO:0003682 chromatin binding GSVIVG01008945001 3700491 3718099 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with chromatin, the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase. IEA GO:0003682 chromatin binding GSVIVG01008945001 3700491 3718099 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with chromatin, the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase. IEA GO:0003682 chromatin binding GSVIVG01008945001 3700491 3718099 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008945001 3700491 3718099 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008945001 3700491 3718099 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008945001 3700491 3718099 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008945001 3700491 3718099 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008945001 3700491 3718099 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008945001 3700491 3718099 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01008945001 3700491 3718099 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01008945001 3700491 3718099 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01008945001 3700491 3718099 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01008945001 3700491 3718099 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01008945001 3700491 3718099 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01037274001 16610144 16612096 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01037274001 16610144 16612096 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037274001 16610144 16612096 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01037274001 16610144 16612096 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01034017001 15818802 15825125 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0009317 acetyl-CoA carboxylase complex A protein complex that catalyzes the first step in long-chain fatty acid biosynthesis. For example, in E. coli the complex is heterohexameric and composed of biotin carbonyl carrier protein, biotin carboxylase and the acetate CoA-transferase complex. IEA Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA. IEA GO:0003989 acetyl-CoA carboxylase activity GSVIVG01034017001 15818802 15825125 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0009317 acetyl-CoA carboxylase complex A protein complex that catalyzes the first step in long-chain fatty acid biosynthesis. For example, in E. coli the complex is heterohexameric and composed of biotin carbonyl carrier protein, biotin carboxylase and the acetate CoA-transferase complex. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01011868001 3422552 3423477 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01012487001 13783130 13784495 GSVIVG01035544001 2169068 2172033 GSVIVG01018047001 5781664 5784239 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01018047001 5781664 5784239 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01018047001 5781664 5784239 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01020232001 8787896 8807169 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01020232001 8787896 8807169 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020232001 8787896 8807169 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01029173001 18947060 18948431 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01029173001 18947060 18948431 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01029173001 18947060 18948431 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01029173001 18947060 18948431 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01029173001 18947060 18948431 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01029173001 18947060 18948431 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01029173001 18947060 18948431 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01029173001 18947060 18948431 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01026725001 5642993 5646012 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026725001 5642993 5646012 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017349001 7066390 7072358 GO:0006168 adenine salvage Any process that generates adenine, 6-aminopurine, from derivatives of it without de novo synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate. IEA GO:0003999 adenine phosphoribosyltransferase activity GSVIVG01017349001 7066390 7072358 GO:0009116 nucleoside metabolic process The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine). IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate. IEA GO:0003999 adenine phosphoribosyltransferase activity GSVIVG01013815001 4735371 4735955 GSVIVG01017236001 5759463 5762990 Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01017236001 5759463 5762990 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01017236001 5759463 5762990 Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01001121001 22777581 22797480 GSVIVG01015284001 2383672 2384701 GSVIVG01015100001 1044421 1045856 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01017556001 10510503 10514598 GSVIVG01026127001 12675293 12678343 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: a phenyl acetate + H2O = a phenol + acetate. IEA GO:0004064 arylesterase activity GSVIVG01026127001 12675293 12678343 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: 3-alpha(S)-strictosidine = tryptamine + secologanin. IEA GO:0016844 strictosidine synthase activity GSVIVG01010249001 18321180 18322563 GSVIVG01038080001 17645200 17647650 GSVIVG01015004001 373298 383542 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01015004001 373298 383542 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01015004001 373298 383542 GO:0046488 phosphatidylinositol metabolic process The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01015004001 373298 383542 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01015004001 373298 383542 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01015004001 373298 383542 GO:0046488 phosphatidylinositol metabolic process The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01015004001 373298 383542 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015004001 373298 383542 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015004001 373298 383542 GO:0046488 phosphatidylinositol metabolic process The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015004001 373298 383542 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01015004001 373298 383542 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01015004001 373298 383542 GO:0046488 phosphatidylinositol metabolic process The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01015004001 373298 383542 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of phosphatidylinositol phosphate to produce phosphatidylinositol bisphosphate. IEA GO:0016307 phosphatidylinositol phosphate kinase activity GSVIVG01015004001 373298 383542 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA Catalysis of the phosphorylation of phosphatidylinositol phosphate to produce phosphatidylinositol bisphosphate. IEA GO:0016307 phosphatidylinositol phosphate kinase activity GSVIVG01015004001 373298 383542 GO:0046488 phosphatidylinositol metabolic process The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. IEA Catalysis of the phosphorylation of phosphatidylinositol phosphate to produce phosphatidylinositol bisphosphate. IEA GO:0016307 phosphatidylinositol phosphate kinase activity GSVIVG01008395001 2514165 2540954 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01038756001 510073 553252 GSVIVG01032773001 869374 869910 GSVIVG01017789001 3485752 3493842 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01017789001 3485752 3493842 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01017789001 3485752 3493842 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01017789001 3485752 3493842 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006578001 26593554 26596438 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01006578001 26593554 26596438 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01006578001 26593554 26596438 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01006578001 26593554 26596438 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001926001 14860945 14862526 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0000808 origin recognition complex A multisubunit complex that is located at the replication origins of a chromosome. IEA GSVIVG01001926001 14860945 14862526 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01025694001 12912601 12914926 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01025694001 12912601 12914926 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01025694001 12912601 12914926 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01025694001 12912601 12914926 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01025694001 12912601 12914926 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025694001 12912601 12914926 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01011439001 29677219 29681333 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01011589001 6173133 6176111 GSVIVG01029506001 22202710 22202975 GSVIVG01005236001 19727630 19737917 GSVIVG01004913001 4757276 4758589 GSVIVG01029067001 11790523 11790729 GSVIVG01030231001 10222470 10225428 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01033031001 25208788 25210330 GSVIVG01029901001 1207805 1226327 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029901001 1207805 1226327 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029901001 1207805 1226327 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029901001 1207805 1226327 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029901001 1207805 1226327 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029901001 1207805 1226327 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029901001 1207805 1226327 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01029901001 1207805 1226327 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01029901001 1207805 1226327 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01029901001 1207805 1226327 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01029901001 1207805 1226327 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01029901001 1207805 1226327 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01029901001 1207805 1226327 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01029901001 1207805 1226327 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01029901001 1207805 1226327 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01029901001 1207805 1226327 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01029901001 1207805 1226327 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01029901001 1207805 1226327 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01029901001 1207805 1226327 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01029901001 1207805 1226327 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01029901001 1207805 1226327 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01029901001 1207805 1226327 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01029901001 1207805 1226327 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01029901001 1207805 1226327 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01009470001 8633939 8637255 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01009470001 8633939 8637255 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01009470001 8633939 8637255 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01009470001 8633939 8637255 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016451001 3771568 3779738 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01016451001 3771568 3779738 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01016451001 3771568 3779738 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01016451001 3771568 3779738 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01033859001 17199708 17201882 GSVIVG01030166001 10903199 10907589 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01030166001 10903199 10907589 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01030166001 10903199 10907589 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026803001 7490058 7494519 Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. IEA GO:0008171 O-methyltransferase activity GSVIVG01003577001 10824817 10825231 GSVIVG01034136001 14910379 14911704 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01027460001 16564401 16565667 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01027460001 16564401 16565667 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with double-stranded RNA. IEA GO:0003725 double-stranded RNA binding GSVIVG01019328001 1071742 1080344 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Interacting selectively and non-covalently with chromatin, the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase. IEA GO:0003682 chromatin binding GSVIVG01019328001 1071742 1080344 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with chromatin, the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase. IEA GO:0003682 chromatin binding GSVIVG01020010001 11618115 11623032 GSVIVG01034089001 15252698 15262033 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01034089001 15252698 15262033 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01034089001 15252698 15262033 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01034089001 15252698 15262033 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006725001 1265393 1274027 GSVIVG01018533001 13732519 13734092 GSVIVG01036493001 22649341 22651510 GSVIVG01020792001 1925920 1930474 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01033496001 20244178 20247931 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01033496001 20244178 20247931 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033496001 20244178 20247931 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity. IEA GO:0004721 phosphoprotein phosphatase activity GSVIVG01033496001 20244178 20247931 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. IEA GO:0004722 protein serine/threonine phosphatase activity GSVIVG01033496001 20244178 20247931 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01033496001 20244178 20247931 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01012810001 5607921 5618868 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013077001 8692317 8703054 GSVIVG01032962001 24631131 24635000 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01005414001 40105059 40106376 GSVIVG01037797001 7855565 7864719 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004185 serine-type carboxypeptidase activity GSVIVG01033855001 17220270 17221466 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01033855001 17220270 17221466 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds. IEA GO:0015035 protein disulfide oxidoreductase activity GSVIVG01010872001 16585403 16590623 GSVIVG01007224001 30946493 30948824 GSVIVG01004827001 5483803 5484545 GSVIVG01036473001 22507642 22508026 GSVIVG01031667001 19871694 19875293 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the reaction: pectin + n H2O = n methanol + pectate. IEA GO:0030599 pectinesterase activity GSVIVG01025230001 2981734 2995237 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025230001 2981734 2995237 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025230001 2981734 2995237 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01025230001 2981734 2995237 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01027570001 15460968 15476735 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027570001 15460968 15476735 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027570001 15460968 15476735 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01027570001 15460968 15476735 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a nucleotidyl group to a reactant. IEA GO:0016779 nucleotidyltransferase activity GSVIVG01027570001 15460968 15476735 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. IEA GO:0048037 cofactor binding GSVIVG01027570001 15460968 15476735 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01003966001 26355600 26365014 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012054001 1763684 1770381 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01012054001 1763684 1770381 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01023985001 1915764 1917733 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA GSVIVG01024261001 332542 337690 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01024261001 332542 337690 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01024261001 332542 337690 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01024261001 332542 337690 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01024261001 332542 337690 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA A sigma factor is the promoter specificity subunit of eubacterial-type multisubunit RNA polymerases, those whose core subunit composition is often described as alpha(2)-beta-beta-prime. (This type of multisubunit RNA polymerase complex is known to be found in eubacteria and plant plastids). Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, this binds specifically to promoter sequences, with the sigma factor making sequence specific contacts with the promoter elements. The sigma subunit is released from the elongating form of the polymerase and is thus free to act catalytically for multiple RNA polymerase core enzymes. IEA GO:0016987 sigma factor activity GSVIVG01024261001 332542 337690 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA A sigma factor is the promoter specificity subunit of eubacterial-type multisubunit RNA polymerases, those whose core subunit composition is often described as alpha(2)-beta-beta-prime. (This type of multisubunit RNA polymerase complex is known to be found in eubacteria and plant plastids). Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, this binds specifically to promoter sequences, with the sigma factor making sequence specific contacts with the promoter elements. The sigma subunit is released from the elongating form of the polymerase and is thus free to act catalytically for multiple RNA polymerase core enzymes. IEA GO:0016987 sigma factor activity GSVIVG01027539001 15906646 15909432 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01027539001 15906646 15909432 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01027539001 15906646 15909432 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01027539001 15906646 15909432 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01001552001 28250 31170 GSVIVG01010488001 21012646 21026739 GSVIVG01008067001 6125834 6126856 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008067001 6125834 6126856 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008067001 6125834 6126856 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008067001 6125834 6126856 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008067001 6125834 6126856 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008067001 6125834 6126856 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008067001 6125834 6126856 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008067001 6125834 6126856 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008067001 6125834 6126856 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01008067001 6125834 6126856 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01008067001 6125834 6126856 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01008067001 6125834 6126856 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01008067001 6125834 6126856 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008067001 6125834 6126856 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008067001 6125834 6126856 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008067001 6125834 6126856 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008067001 6125834 6126856 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + methylthioadenosine. IEA GO:0016847 1-aminocyclopropane-1-carboxylate synthase activity GSVIVG01008067001 6125834 6126856 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + methylthioadenosine. IEA GO:0016847 1-aminocyclopropane-1-carboxylate synthase activity GSVIVG01008067001 6125834 6126856 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + methylthioadenosine. IEA GO:0016847 1-aminocyclopropane-1-carboxylate synthase activity GSVIVG01008067001 6125834 6126856 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + methylthioadenosine. IEA GO:0016847 1-aminocyclopropane-1-carboxylate synthase activity GSVIVG01003476001 10603412 10611952 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0008021 synaptic vesicle A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and is secreted these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01003476001 10603412 10611952 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033696001 18510762 18570208 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032339001 15273242 15274983 GSVIVG01009650001 10206798 10210522 GSVIVG01011172001 7716574 7721001 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Interacting selectively and non-covalently with selenium (Se). IEA GO:0008430 selenium binding GSVIVG01030445001 5609780 5612356 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA GSVIVG01030445001 5609780 5612356 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01028977001 16950218 16957354 GSVIVG01034549001 19587111 19592826 GSVIVG01019235001 2960575 2962182 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031690001 20228612 20244419 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01029229001 18289586 18291665 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01029229001 18289586 18291665 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01029229001 18289586 18291665 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029229001 18289586 18291665 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01026991001 18754824 18759433 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01026991001 18754824 18759433 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01026991001 18754824 18759433 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01026991001 18754824 18759433 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01033494001 20249818 20252600 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033494001 20249818 20252600 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036944001 17148051 17187066 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01036944001 17148051 17187066 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01036944001 17148051 17187066 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01036944001 17148051 17187066 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01036944001 17148051 17187066 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01036944001 17148051 17187066 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01036944001 17148051 17187066 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036944001 17148051 17187066 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036944001 17148051 17187066 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036944001 17148051 17187066 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01036944001 17148051 17187066 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01036944001 17148051 17187066 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01036944001 17148051 17187066 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwinding of the DNA helix in the direction 3' to 5'. IEA GO:0043140 ATP-dependent 3'-5' DNA helicase activity GSVIVG01036944001 17148051 17187066 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwinding of the DNA helix in the direction 3' to 5'. IEA GO:0043140 ATP-dependent 3'-5' DNA helicase activity GSVIVG01036944001 17148051 17187066 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwinding of the DNA helix in the direction 3' to 5'. IEA GO:0043140 ATP-dependent 3'-5' DNA helicase activity GSVIVG01009651001 10213823 10217931 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01034112001 15077914 15080673 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01034112001 15077914 15080673 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01034112001 15077914 15080673 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01034112001 15077914 15080673 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01034112001 15077914 15080673 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01034112001 15077914 15080673 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01034112001 15077914 15080673 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01034112001 15077914 15080673 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01034112001 15077914 15080673 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01034112001 15077914 15080673 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01034112001 15077914 15080673 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01034112001 15077914 15080673 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01034112001 15077914 15080673 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01034112001 15077914 15080673 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01034112001 15077914 15080673 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021064001 14230837 14235424 GSVIVG01031990001 23721405 23723651 GSVIVG01025547001 14139513 14146564 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01025547001 14139513 14146564 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01005253001 19887561 19887944 GSVIVG01036145001 20199446 20200942 GSVIVG01029730001 13796494 13820720 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01029730001 13796494 13820720 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01029730001 13796494 13820720 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01029730001 13796494 13820720 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01035999001 6999686 7004075 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01035999001 6999686 7004075 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01000765001 528283 529974 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01000765001 528283 529974 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01000765001 528283 529974 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01000765001 528283 529974 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01035215001 10683930 10694055 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01027916001 9358204 9364678 GSVIVG01017585001 10981984 10982214 GSVIVG01032654001 1793808 1795013 GSVIVG01022375001 19281239 19281913 GSVIVG01017814001 3676950 3684048 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01017814001 3676950 3684048 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01017814001 3676950 3684048 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01017814001 3676950 3684048 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01017814001 3676950 3684048 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01017814001 3676950 3684048 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01017814001 3676950 3684048 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01017814001 3676950 3684048 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01017814001 3676950 3684048 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01017814001 3676950 3684048 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01017814001 3676950 3684048 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01017814001 3676950 3684048 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01017814001 3676950 3684048 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01017814001 3676950 3684048 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01017814001 3676950 3684048 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01017814001 3676950 3684048 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01017814001 3676950 3684048 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01017814001 3676950 3684048 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01017814001 3676950 3684048 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01017814001 3676950 3684048 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01017814001 3676950 3684048 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01017814001 3676950 3684048 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01017814001 3676950 3684048 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01017814001 3676950 3684048 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01017814001 3676950 3684048 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01017814001 3676950 3684048 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01017814001 3676950 3684048 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01017814001 3676950 3684048 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01017814001 3676950 3684048 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01017814001 3676950 3684048 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01017814001 3676950 3684048 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01017814001 3676950 3684048 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01017814001 3676950 3684048 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01017814001 3676950 3684048 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01017814001 3676950 3684048 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01017814001 3676950 3684048 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01017814001 3676950 3684048 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01017814001 3676950 3684048 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01017814001 3676950 3684048 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01017814001 3676950 3684048 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01017814001 3676950 3684048 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01017814001 3676950 3684048 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01017814001 3676950 3684048 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01017814001 3676950 3684048 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01017814001 3676950 3684048 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01017814001 3676950 3684048 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01017814001 3676950 3684048 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01017814001 3676950 3684048 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01011605001 6034340 6035646 GSVIVG01018090001 6392295 6394940 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032375001 26798200 26801704 GSVIVG01003418001 14816532 14821559 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01003418001 14816532 14821559 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01031070001 21818967 21823520 Interacting selectively and non-covalently with a specific domain of a protein. IEA GO:0019904 protein domain specific binding GSVIVG01022862001 18683693 18687934 GSVIVG01013879001 5875435 5877514 GSVIVG01009324001 7443689 7448671 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01027458001 16583085 16590600 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01027458001 16583085 16590600 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01027458001 16583085 16590600 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01027458001 16583085 16590600 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032973001 24735792 24738691 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01021575001 7350497 7353093 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01015842001 18194163 18194547 GSVIVG01012806001 5557470 5575151 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01026964001 18965855 18980794 GO:0006887 exocytosis A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell. This is the process whereby most molecules are secreted from eukaryotic cells. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA GSVIVG01026964001 18965855 18980794 GO:0048278 vesicle docking The initial attachment of a transport vesicle membrane to the target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA GSVIVG01020068001 10843187 10845074 Catalysis of the eliminative cleavage of pectate to give oligosaccharides with 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their non-reducing ends. IEA GO:0030570 pectate lyase activity GSVIVG01033408001 20916478 20918449 GSVIVG01004900001 16670339 16670395 GSVIVG01009602001 9794862 9802663 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01009602001 9794862 9802663 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01009602001 9794862 9802663 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01009602001 9794862 9802663 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01012988001 10591347 10591814 GSVIVG01009489001 8790188 8809595 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01009489001 8790188 8809595 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01009489001 8790188 8809595 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01009489001 8790188 8809595 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033313001 21597066 21602704 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01033313001 21597066 21602704 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016602 CCAAT-binding factor complex A heteromeric transcription factor complex that binds to the CCAAT-box upstream of promoters; in Saccharomyces it activates the transcription of genes in response to growth in a nonfermentable carbon source; consists of four known subunits: HAP2, HAP3, HAP4 and HAP5. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01033313001 21597066 21602704 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01033313001 21597066 21602704 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016602 CCAAT-binding factor complex A heteromeric transcription factor complex that binds to the CCAAT-box upstream of promoters; in Saccharomyces it activates the transcription of genes in response to growth in a nonfermentable carbon source; consists of four known subunits: HAP2, HAP3, HAP4 and HAP5. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01007139001 30348670 30349308 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01024101001 1049127 1061006 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024101001 1049127 1061006 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024812001 6679230 6681906 GSVIVG01003874001 76347 90230 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01003874001 76347 90230 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01007975001 7045793 7050331 GO:0006821 chloride transport The directed movement of chloride into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a chloride ion by a voltage-gated channel. IEA GO:0005247 voltage-gated chloride channel activity GSVIVG01007975001 7045793 7050331 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a chloride ion by a voltage-gated channel. IEA GO:0005247 voltage-gated chloride channel activity GSVIVG01007975001 7045793 7050331 GO:0006821 chloride transport The directed movement of chloride into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01007975001 7045793 7050331 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01007975001 7045793 7050331 GO:0006821 chloride transport The directed movement of chloride into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01007975001 7045793 7050331 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01023295001 20002494 20011409 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01023295001 20002494 20011409 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01023295001 20002494 20011409 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01023295001 20002494 20011409 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01005380001 40002662 40006174 GSVIVG01020626001 3668703 3670004 Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. IEA GO:0008171 O-methyltransferase activity GSVIVG01004935001 21636777 21647857 GSVIVG01022075001 16393992 16400841 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01022075001 16393992 16400841 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01038717001 20642046 20646255 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01038717001 20642046 20646255 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008742001 1619217 1620812 GSVIVG01038310001 12594845 12595048 GSVIVG01030309001 9121346 9149835 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01030309001 9121346 9149835 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01030309001 9121346 9149835 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01030309001 9121346 9149835 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01030309001 9121346 9149835 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025602001 13687876 13688361 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01018003001 5401210 5402158 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. IEA GO:0008080 N-acetyltransferase activity GSVIVG01018003001 5401210 5402158 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01011897001 3190693 3194443 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01011901001 3147326 3149350 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01011901001 3147326 3149350 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01011901001 3147326 3149350 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01011901001 3147326 3149350 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01011901001 3147326 3149350 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01011901001 3147326 3149350 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01011901001 3147326 3149350 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01011901001 3147326 3149350 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01022319001 18443483 18452666 GO:0030071 regulation of mitotic metaphase/anaphase transition Any process that modulates the frequency, rate or extent of the onset of anaphase (chromosome movement) in the mitotic cell cycle. IEA GO:0005680 anaphase-promoting complex A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01000420001 7745647 7747875 GSVIVG01030485001 6092559 6094690 GSVIVG01000901001 4275048 4276284 GSVIVG01037942001 11240927 11255918 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01037942001 11240927 11255918 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01023598001 7827617 7833106 GSVIVG01021460001 5630646 5647808 GSVIVG01030741001 14917134 14917995 GSVIVG01021205001 2543463 2543965 GO:0009082 branched chain family amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. IEA Catalysis of the reaction: (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+. IEA GO:0004455 ketol-acid reductoisomerase activity GSVIVG01021205001 2543463 2543965 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+. IEA GO:0004455 ketol-acid reductoisomerase activity GSVIVG01021205001 2543463 2543965 GO:0009082 branched chain family amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021205001 2543463 2543965 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021205001 2543463 2543965 GO:0009082 branched chain family amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01021205001 2543463 2543965 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01020758001 2309877 2311452 GSVIVG01001327001 5378526 5380976 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the reaction: pectin + n H2O = n methanol + pectate. IEA GO:0030599 pectinesterase activity GSVIVG01008092001 5844252 5847111 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005875 microtubule associated complex Any multimeric complex connected to a microtubule. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01014889001 11208149 11208477 GSVIVG01008226001 4483062 4492879 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA GSVIVG01017363001 7337145 7351237 GO:0007154 cell communication Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017363001 7337145 7351237 GO:0007154 cell communication Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. IEA Interacting selectively and non-covalently with any inositol-containing glycerophospholipid. Phosphatidylinositol (PtdIns) and its phosphorylated derivatives are collectively referred to as phosphoinositides (PIs). IEA GO:0035091 phosphoinositide binding GSVIVG01005550001 40599237 40599874 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01005550001 40599237 40599874 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01005550001 40599237 40599874 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01005550001 40599237 40599874 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01004096001 14765137 14772218 GO:0032313 regulation of Rab GTPase activity Any process that modulates the activity of a GTPase of the Rab family. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Increases the rate of GTP hydrolysis by a GTPase of the Rab family. IEA GO:0005097 Rab GTPase activator activity GSVIVG01030211001 10392440 10407067 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01030211001 10392440 10407067 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01015717001 16302154 16303017 GSVIVG01022561001 5062283 5086411 GSVIVG01036968001 9413165 9433562 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01036968001 9413165 9433562 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain. IEA GO:0004177 aminopeptidase activity GSVIVG01024636001 8163557 8166095 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01024636001 8163557 8166095 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01017796001 3549321 3551930 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01017796001 3549321 3551930 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01032140001 22263676 22269885 GSVIVG01029953001 2060775 2111425 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01029953001 2060775 2111425 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end. IEA GO:0008408 3'-5' exonuclease activity GSVIVG01037110001 29070859 29074288 GSVIVG01001902001 7003305 7006523 GO:0006548 histidine catabolic process The chemical reactions and pathways resulting in the breakdown of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. IEA Catalysis of the reaction: 3,4-dihydroxyphenethylamine + ascorbate + O2 = noradrenaline + dehydroascorbate + H2O. IEA GO:0004500 dopamine beta-monooxygenase activity GSVIVG01024891001 6208777 6214898 GSVIVG01025496001 318044 325141 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019646001 2178575 2181567 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GSVIVG01027267001 17353125 17358904 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027267001 17353125 17358904 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019306001 1509059 1510311 GSVIVG01022827001 19006954 19007943 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01022827001 19006954 19007943 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01022827001 19006954 19007943 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01022827001 19006954 19007943 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032208001 21546000 21547853 GSVIVG01025311001 2161238 2161501 GSVIVG01019093001 16779757 16780072 GSVIVG01028873001 17920090 17930273 GO:0042773 ATP synthesis coupled electron transport The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01028873001 17920090 17930273 GO:0042773 ATP synthesis coupled electron transport The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01028873001 17920090 17930273 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01028873001 17920090 17930273 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01028873001 17920090 17930273 GO:0042773 ATP synthesis coupled electron transport The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. IEA GO:0008137 NADH dehydrogenase (ubiquinone) activity GSVIVG01028873001 17920090 17930273 GO:0042773 ATP synthesis coupled electron transport The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. IEA GO:0008137 NADH dehydrogenase (ubiquinone) activity GSVIVG01028873001 17920090 17930273 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. IEA GO:0008137 NADH dehydrogenase (ubiquinone) activity GSVIVG01028873001 17920090 17930273 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. IEA GO:0008137 NADH dehydrogenase (ubiquinone) activity GSVIVG01028873001 17920090 17930273 GO:0042773 ATP synthesis coupled electron transport The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01028873001 17920090 17930273 GO:0042773 ATP synthesis coupled electron transport The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01028873001 17920090 17930273 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01028873001 17920090 17930273 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01028873001 17920090 17930273 GO:0042773 ATP synthesis coupled electron transport The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01028873001 17920090 17930273 GO:0042773 ATP synthesis coupled electron transport The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01028873001 17920090 17930273 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01028873001 17920090 17930273 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01028873001 17920090 17930273 GO:0042773 ATP synthesis coupled electron transport The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01028873001 17920090 17930273 GO:0042773 ATP synthesis coupled electron transport The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01028873001 17920090 17930273 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01028873001 17920090 17930273 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01007689001 10362993 10368275 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01007689001 10362993 10368275 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01007689001 10362993 10368275 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007689001 10362993 10368275 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01007689001 10362993 10368275 Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01007689001 10362993 10368275 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01024577001 8673001 8679927 GSVIVG01032711001 1330307 1336801 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027149001 17410999 17413737 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01038487001 10230649 10232611 GSVIVG01035649001 2986004 2987436 GSVIVG01004866001 16202662 16210316 GSVIVG01029117001 19444158 19455408 GSVIVG01012452001 1025881 1032502 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019726001 2767981 2771510 GSVIVG01032876001 12083 63791 GO:0016049 cell growth The process by which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present. IEA Interacting selectively and non-covalently with the transforming growth factor beta receptor. IEA GO:0005160 transforming growth factor beta receptor binding GSVIVG01032876001 12083 63791 GO:0016049 cell growth The process by which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032876001 12083 63791 GO:0016049 cell growth The process by which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01021157001 1963969 1964410 GSVIVG01018563001 13310611 13327685 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018563001 13310611 13327685 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the repair of a photoproduct resulting from ultraviolet irradiation of two adjacent pyrimidine residues in DNA. IEA GO:0003913 DNA photolyase activity GSVIVG01015816001 17820577 17828165 GSVIVG01000752001 381035 383836 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01000752001 381035 383836 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01029680001 12949384 12964105 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01000389001 582058 609270 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000389001 582058 609270 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01000970001 22356991 22364888 GSVIVG01033634001 19080982 19082497 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004197 cysteine-type endopeptidase activity GSVIVG01033634001 19080982 19082497 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01013357001 1007920 1011012 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01013357001 1007920 1011012 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01013357001 1007920 1011012 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01013357001 1007920 1011012 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01002001001 6182059 6184697 GSVIVG01037850001 7137412 7143834 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01013816001 4741294 4741741 GSVIVG01011763001 4389237 4395124 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01011763001 4389237 4395124 GO:0009435 NAD biosynthetic process The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01011763001 4389237 4395124 GO:0019363 pyridine nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01011763001 4389237 4395124 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: nicotinate D-ribonucleotide + diphosphate + CO2 = pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate. IEA GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity GSVIVG01011763001 4389237 4395124 GO:0009435 NAD biosynthetic process The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH. IEA Catalysis of the reaction: nicotinate D-ribonucleotide + diphosphate + CO2 = pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate. IEA GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity GSVIVG01011763001 4389237 4395124 GO:0019363 pyridine nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base. IEA Catalysis of the reaction: nicotinate D-ribonucleotide + diphosphate + CO2 = pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate. IEA GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity GSVIVG01027993001 3058817 3060884 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA GSVIVG01034101001 15144714 15149849 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025211001 3275256 3275741 GSVIVG01019106001 16733927 16734217 GSVIVG01009531001 9101794 9105297 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA GSVIVG01009531001 9101794 9105297 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA GSVIVG01009531001 9101794 9105297 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA GSVIVG01009531001 9101794 9105297 GO:0009405 pathogenesis The set of specific processes that generate the ability of an organism to cause disease in another. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA GSVIVG01035578001 2476208 2484277 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01002319001 34094693 34103642 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01002319001 34094693 34103642 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01002319001 34094693 34103642 Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01002319001 34094693 34103642 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01032930001 24240450 24247767 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01037480001 12945849 12946181 GSVIVG01016572001 2689505 2690199 GSVIVG01029340001 14668241 14673945 GSVIVG01017933001 4831093 4846705 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0008076 voltage-gated potassium channel complex A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01017933001 4831093 4846705 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01017933001 4831093 4846705 GO:0006821 chloride transport The directed movement of chloride into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0008076 voltage-gated potassium channel complex A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01017933001 4831093 4846705 GO:0006821 chloride transport The directed movement of chloride into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01017933001 4831093 4846705 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0008076 voltage-gated potassium channel complex A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01017933001 4831093 4846705 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01017933001 4831093 4846705 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0008076 voltage-gated potassium channel complex A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. IEA Catalysis of the transmembrane transfer of a chloride ion by a voltage-gated channel. IEA GO:0005247 voltage-gated chloride channel activity GSVIVG01017933001 4831093 4846705 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a chloride ion by a voltage-gated channel. IEA GO:0005247 voltage-gated chloride channel activity GSVIVG01017933001 4831093 4846705 GO:0006821 chloride transport The directed movement of chloride into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0008076 voltage-gated potassium channel complex A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. IEA Catalysis of the transmembrane transfer of a chloride ion by a voltage-gated channel. IEA GO:0005247 voltage-gated chloride channel activity GSVIVG01017933001 4831093 4846705 GO:0006821 chloride transport The directed movement of chloride into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a chloride ion by a voltage-gated channel. IEA GO:0005247 voltage-gated chloride channel activity GSVIVG01017933001 4831093 4846705 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0008076 voltage-gated potassium channel complex A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. IEA Catalysis of the transmembrane transfer of a chloride ion by a voltage-gated channel. IEA GO:0005247 voltage-gated chloride channel activity GSVIVG01017933001 4831093 4846705 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a chloride ion by a voltage-gated channel. IEA GO:0005247 voltage-gated chloride channel activity GSVIVG01017933001 4831093 4846705 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0008076 voltage-gated potassium channel complex A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01017933001 4831093 4846705 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01017933001 4831093 4846705 GO:0006821 chloride transport The directed movement of chloride into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0008076 voltage-gated potassium channel complex A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01017933001 4831093 4846705 GO:0006821 chloride transport The directed movement of chloride into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01017933001 4831093 4846705 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0008076 voltage-gated potassium channel complex A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01017933001 4831093 4846705 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01017933001 4831093 4846705 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0008076 voltage-gated potassium channel complex A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. IEA Catalysis of facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005267 potassium channel activity GSVIVG01017933001 4831093 4846705 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005267 potassium channel activity GSVIVG01017933001 4831093 4846705 GO:0006821 chloride transport The directed movement of chloride into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0008076 voltage-gated potassium channel complex A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. IEA Catalysis of facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005267 potassium channel activity GSVIVG01017933001 4831093 4846705 GO:0006821 chloride transport The directed movement of chloride into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005267 potassium channel activity GSVIVG01017933001 4831093 4846705 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0008076 voltage-gated potassium channel complex A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. IEA Catalysis of facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005267 potassium channel activity GSVIVG01017933001 4831093 4846705 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005267 potassium channel activity GSVIVG01026715001 5342343 5356199 GO:0006298 mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026715001 5342343 5356199 GO:0006298 mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches. IEA GO:0030983 mismatched DNA binding GSVIVG01005455001 40336846 40338250 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01005455001 40336846 40338250 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). IEA GO:0016769 transferase activity, transferring nitrogenous groups GSVIVG01005455001 40336846 40338250 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + methylthioadenosine. IEA GO:0016847 1-aminocyclopropane-1-carboxylate synthase activity GSVIVG01005455001 40336846 40338250 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01012000001 2301129 2308453 GSVIVG01019400001 343029 346156 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01019400001 343029 346156 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01014558001 5156208 5159153 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01014558001 5156208 5159153 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01020616001 3728058 3728958 GSVIVG01019611001 1943329 1943906 GSVIVG01035794001 4415690 4418065 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01035794001 4415690 4418065 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01000497001 15020746 15036441 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01000497001 15020746 15036441 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01000497001 15020746 15036441 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01000497001 15020746 15036441 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01029508001 22150436 22172921 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01020954001 16458019 16461087 GSVIVG01002750001 36357776 36362447 GSVIVG01010497001 21076452 21078724 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021874001 6132781 6138207 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021874001 6132781 6138207 GO:0006535 cysteine biosynthetic process from serine The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021874001 6132781 6138207 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021874001 6132781 6138207 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021874001 6132781 6138207 GO:0019344 cysteine biosynthetic process The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021874001 6132781 6138207 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: O3-acetyl-L-serine + H2S = L-cysteine + acetate. IEA GO:0004124 cysteine synthase activity GSVIVG01021874001 6132781 6138207 GO:0006535 cysteine biosynthetic process from serine The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: O3-acetyl-L-serine + H2S = L-cysteine + acetate. IEA GO:0004124 cysteine synthase activity GSVIVG01021874001 6132781 6138207 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: O3-acetyl-L-serine + H2S = L-cysteine + acetate. IEA GO:0004124 cysteine synthase activity GSVIVG01021874001 6132781 6138207 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: O3-acetyl-L-serine + H2S = L-cysteine + acetate. IEA GO:0004124 cysteine synthase activity GSVIVG01021874001 6132781 6138207 GO:0019344 cysteine biosynthetic process The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: O3-acetyl-L-serine + H2S = L-cysteine + acetate. IEA GO:0004124 cysteine synthase activity GSVIVG01021874001 6132781 6138207 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01021874001 6132781 6138207 GO:0006535 cysteine biosynthetic process from serine The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01021874001 6132781 6138207 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01021874001 6132781 6138207 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01021874001 6132781 6138207 GO:0019344 cysteine biosynthetic process The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01021874001 6132781 6138207 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01021874001 6132781 6138207 GO:0006535 cysteine biosynthetic process from serine The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01021874001 6132781 6138207 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01021874001 6132781 6138207 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01021874001 6132781 6138207 GO:0019344 cysteine biosynthetic process The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01021874001 6132781 6138207 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01021874001 6132781 6138207 GO:0006535 cysteine biosynthetic process from serine The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01021874001 6132781 6138207 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01021874001 6132781 6138207 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01021874001 6132781 6138207 GO:0019344 cysteine biosynthetic process The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01008872001 2929071 2940502 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028556001 9674131 9731228 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01028556001 9674131 9731228 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01028556001 9674131 9731228 GO:0030259 lipid glycosylation Covalent attachment of a glycosyl residue to a lipid molecule. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01026680001 4704955 4705092 GSVIVG01024609001 8450418 8454891 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024609001 8450418 8454891 Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. IEA GO:0008483 transaminase activity GSVIVG01024609001 8450418 8454891 Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01005610001 40866253 40869054 GSVIVG01003606001 11199969 11201235 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003606001 11199969 11201235 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01003648001 11650260 11653920 GSVIVG01000691001 15646369 15646734 GSVIVG01031685001 20174784 20177177 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01031685001 20174784 20177177 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01031509001 17784531 17802023 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01006265001 24322883 24325899 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01006265001 24322883 24325899 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01025404001 1036316 1052248 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025404001 1036316 1052248 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01030552001 6668582 6669621 GSVIVG01016992001 3244545 3246079 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01011917001 3021584 3030196 GSVIVG01033337001 21372496 21377342 GSVIVG01032306001 14836172 14838781 GSVIVG01018210001 13193675 13194680 GSVIVG01021842001 6616292 6617329 GSVIVG01005331001 39636703 39637351 Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01018820001 19605006 19607076 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018820001 19605006 19607076 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018820001 19605006 19607076 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the reaction: D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate. IEA GO:0004332 fructose-bisphosphate aldolase activity GSVIVG01018820001 19605006 19607076 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate. IEA GO:0004332 fructose-bisphosphate aldolase activity GSVIVG01007706001 10170749 10178460 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01007706001 10170749 10178460 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01007706001 10170749 10178460 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01007706001 10170749 10178460 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01007706001 10170749 10178460 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019170001 4348637 4349407 GSVIVG01018795001 19792529 19795338 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01015451001 3799212 3804104 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0000159 protein phosphatase type 2A complex A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit. IEA Modulation of the activity of the enzyme protein phosphatase type 2A. IEA GO:0008601 protein phosphatase type 2A regulator activity GSVIVG01006148001 42140091 42140645 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01006148001 42140091 42140645 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the ligation of ammonia (NH3) to another substance via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. IEA GO:0016211 ammonia ligase activity GSVIVG01017871001 4183225 4186559 GSVIVG01000542001 7257808 7266807 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01000542001 7257808 7266807 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001961001 16295964 16310858 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01001961001 16295964 16310858 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01026135001 12747374 12747967 GO:0006481 C-terminal protein amino acid methylation The methylation of the C-terminal amino acid of a protein. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester. IEA GO:0004671 protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity GSVIVG01019037001 17490613 17491727 GSVIVG01001164001 1153067 1153969 GSVIVG01031263001 696936 697771 GSVIVG01031848001 4866536 4866772 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01031848001 4866536 4866772 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01031848001 4866536 4866772 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01028201001 4578717 4584812 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01028201001 4578717 4584812 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01028201001 4578717 4584812 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01028201001 4578717 4584812 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01028201001 4578717 4584812 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01028201001 4578717 4584812 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01005992001 23156449 23162744 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01016468001 3601529 3604067 GO:0005759 mitochondrial matrix The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. IEA GSVIVG01017518001 9824486 9828107 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01017518001 9824486 9828107 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01017518001 9824486 9828107 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01017518001 9824486 9828107 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017518001 9824486 9828107 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031769001 4252223 4254466 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01012823001 5760377 5764675 GSVIVG01026098001 24595027 24597973 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01026098001 24595027 24597973 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01022385001 19459143 19493291 GSVIVG01015367001 3049727 3056046 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015367001 3049727 3056046 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015367001 3049727 3056046 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate. IEA GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity GSVIVG01015367001 3049727 3056046 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate. IEA GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity GSVIVG01015367001 3049727 3056046 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. IEA GO:0008483 transaminase activity GSVIVG01015367001 3049727 3056046 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. IEA GO:0008483 transaminase activity GSVIVG01015367001 3049727 3056046 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01015367001 3049727 3056046 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01015367001 3049727 3056046 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). IEA GO:0016769 transferase activity, transferring nitrogenous groups GSVIVG01015367001 3049727 3056046 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). IEA GO:0016769 transferase activity, transferring nitrogenous groups GSVIVG01015367001 3049727 3056046 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01015367001 3049727 3056046 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01038259001 24754343 24762842 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of poly(ADP-ribose) at glycosidic (1''-2') linkage of ribose-ribose bond to produce free ADP-ribose. IEA GO:0004649 poly(ADP-ribose) glycohydrolase activity GSVIVG01018502001 14245946 14247355 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018502001 14245946 14247355 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01034144001 14849073 14852901 GSVIVG01035462001 1456412 1464354 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01008703001 1319712 1322860 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008703001 1319712 1322860 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008703001 1319712 1322860 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008703001 1319712 1322860 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008703001 1319712 1322860 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008703001 1319712 1322860 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008703001 1319712 1322860 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008703001 1319712 1322860 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01011091001 1675284 1678507 GSVIVG01025807001 11650625 11651251 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01025807001 11650625 11651251 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end. IEA GO:0008408 3'-5' exonuclease activity GSVIVG01024013001 1746495 1748076 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017330001 6770900 6779833 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01018347001 10707133 10712488 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001453001 21127737 21134367 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01001453001 21127737 21134367 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01001453001 21127737 21134367 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001453001 21127737 21134367 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003191001 7746136 7752029 GSVIVG01031860001 4955811 4959737 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01031860001 4955811 4959737 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01031860001 4955811 4959737 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01031860001 4955811 4959737 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031860001 4955811 4959737 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01031860001 4955811 4959737 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01019642001 2145207 2149181 GSVIVG01000120001 15404405 15417570 GO:0000103 sulfate assimilation The pathways by which inorganic sulfate is processed and incorporated into sulfated compounds. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01000120001 15404405 15417570 GO:0009416 response to light stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01000120001 15404405 15417570 GO:0000103 sulfate assimilation The pathways by which inorganic sulfate is processed and incorporated into sulfated compounds. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000120001 15404405 15417570 GO:0009416 response to light stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000120001 15404405 15417570 GO:0000103 sulfate assimilation The pathways by which inorganic sulfate is processed and incorporated into sulfated compounds. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000120001 15404405 15417570 GO:0009416 response to light stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000120001 15404405 15417570 GO:0000103 sulfate assimilation The pathways by which inorganic sulfate is processed and incorporated into sulfated compounds. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01000120001 15404405 15417570 GO:0009416 response to light stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01000120001 15404405 15417570 GO:0000103 sulfate assimilation The pathways by which inorganic sulfate is processed and incorporated into sulfated compounds. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01000120001 15404405 15417570 GO:0009416 response to light stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01000061001 3168610 3168810 GSVIVG01037979001 11980846 11981555 GSVIVG01002139001 33168714 33175056 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01002139001 33168714 33175056 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01016617001 2387669 2421339 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016617001 2387669 2421339 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016617001 2387669 2421339 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016617001 2387669 2421339 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016617001 2387669 2421339 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01016617001 2387669 2421339 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01016617001 2387669 2421339 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01016617001 2387669 2421339 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01016617001 2387669 2421339 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01016617001 2387669 2421339 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01028145001 4178140 4180051 GSVIVG01037061001 8242465 8244586 GSVIVG01018275001 12149757 12151114 GSVIVG01022255001 17884659 17902959 GSVIVG01013248001 6285884 6286527 GSVIVG01026973001 18906291 18918663 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01003868001 15001 18526 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01003868001 15001 18526 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01003868001 15001 18526 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01003868001 15001 18526 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01003868001 15001 18526 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034738001 8707974 8795901 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01027871001 8809255 8847176 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01027871001 8809255 8847176 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01016107001 19086553 19092532 GO:0006506 GPI anchor biosynthetic process The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol moiety is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate moiety, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage. IEA GO:0005789 endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum. IEA GSVIVG01016107001 19086553 19092532 GO:0006506 GPI anchor biosynthetic process The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol moiety is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate moiety, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01005964001 23002963 23003991 GSVIVG01018389001 9875204 9875539 GSVIVG01003836001 20536349 20537931 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01034855001 22806790 22808514 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030625001 7259023 7266272 GSVIVG01019443001 721668 721817 GSVIVG01013324001 12027359 12030717 GSVIVG01028061001 3523652 3524356 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GSVIVG01028061001 3523652 3524356 GO:0009607 response to biotic stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism. IEA GSVIVG01026895001 19592628 19595178 GSVIVG01015663001 15191606 15195649 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. IEA GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GSVIVG01024429001 2470087 2470815 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01020126001 10087355 10090494 GO:0009396 folic acid and derivative biosynthetic process The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020126001 10087355 10090494 GO:0009396 folic acid and derivative biosynthetic process The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. IEA Catalysis of the reaction: ATP + 5-formyltetrahydrofolate = ADP + phosphate + 5,10-methenyltetrahydrofolate. IEA GO:0030272 5-formyltetrahydrofolate cyclo-ligase activity GSVIVG01019445001 727514 734302 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of potassium ions (K+) from one side of a membrane to the other. IEA GO:0015079 potassium ion transmembrane transporter activity GSVIVG01027773001 7580303 7580440 GSVIVG01024478001 3101215 3111034 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024478001 3101215 3111034 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01003875001 108896 156580 GO:0016043 cellular component organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cellular component. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01003875001 108896 156580 GO:0030036 actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01000840001 2758964 2773120 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000840001 2758964 2773120 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000840001 2758964 2773120 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000840001 2758964 2773120 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019677001 2398999 2409960 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin. IEA GO:0004221 ubiquitin thiolesterase activity GSVIVG01029207001 18553723 18566361 GSVIVG01017391001 7797582 7799647 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01017391001 7797582 7799647 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01017391001 7797582 7799647 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017391001 7797582 7799647 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017391001 7797582 7799647 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01017391001 7797582 7799647 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01017391001 7797582 7799647 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01017391001 7797582 7799647 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01035591001 2572122 2577860 GSVIVG01033644001 18994445 18999734 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01033644001 18994445 18999734 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01002242001 33581346 33586990 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01002242001 33581346 33586990 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01029424001 17064481 17065719 GSVIVG01009100001 5035063 5040140 GSVIVG01009108001 5107101 5110250 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01009108001 5107101 5110250 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01009108001 5107101 5110250 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01009108001 5107101 5110250 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01025999001 26047589 26076996 GSVIVG01014119001 548335 549288 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014119001 548335 549288 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014119001 548335 549288 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014119001 548335 549288 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010311001 19287883 19288086 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01010311001 19287883 19288086 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01010311001 19287883 19288086 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01010311001 19287883 19288086 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01014299001 2457284 2460158 GSVIVG01027761001 7468939 7471284 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01027761001 7468939 7471284 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024417001 2293614 2303345 GO:0006621 protein retention in ER lumen The retention in the endoplasmic reticulum (ER) lumen of soluble resident proteins. Sorting receptors retrieve proteins with ER localization signals, such as KDEL and HDEL sequences or some transmembrane domains, that have escaped to the cis-Golgi network and return them to the ER. Abnormally folded proteins and unassembled subunits are also selectively retained in the ER. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with an endoplasmic reticulum (ER) retention sequence, a specific peptide sequence that ensures a protein is retained within the ER. IEA GO:0046923 ER retention sequence binding GSVIVG01022614001 13419774 13426129 Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01008039001 6410692 6413303 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008039001 6410692 6413303 GO:0019318 hexose metabolic process The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008039001 6410692 6413303 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. IEA GO:0016853 isomerase activity GSVIVG01008039001 6410692 6413303 GO:0019318 hexose metabolic process The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule. IEA Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. IEA GO:0016853 isomerase activity GSVIVG01008039001 6410692 6413303 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01008039001 6410692 6413303 GO:0019318 hexose metabolic process The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule. IEA Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01033978001 16139487 16147758 GO:0005795 Golgi stack The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack. IEA Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid. IEA GO:0008378 galactosyltransferase activity GSVIVG01031153001 1673931 1676260 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01032133001 22350276 22352457 GSVIVG01014714001 8923328 8925003 GSVIVG01018702001 10962970 10963695 GO:0022904 respiratory electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01018702001 10962970 10963695 GO:0022904 respiratory electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01034181001 14590119 14590696 GSVIVG01023268001 20407979 20411140 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01008631001 266767 275866 GSVIVG01005713001 21490778 21495450 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01005713001 21490778 21495450 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01005713001 21490778 21495450 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01005713001 21490778 21495450 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01005713001 21490778 21495450 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01005713001 21490778 21495450 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01005713001 21490778 21495450 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01005713001 21490778 21495450 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01005713001 21490778 21495450 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01005713001 21490778 21495450 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020642001 3564082 3565358 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01020642001 3564082 3565358 Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. IEA GO:0008171 O-methyltransferase activity GSVIVG01020642001 3564082 3565358 The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01023815001 3260716 3270012 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01007151001 5412975 5419596 GSVIVG01028698001 19697454 19699843 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028698001 19697454 19699843 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel, where the inward rectification is due to a voltage-dependent block of the channel pore by a G protein. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. IEA GO:0015467 G-protein activated inward rectifier potassium channel activity GSVIVG01003494001 10736766 10738846 GSVIVG01032652001 1806700 1809164 GSVIVG01020160001 9655500 9657867 GSVIVG01024637001 8144672 8149775 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01036889001 18146967 18147327 GSVIVG01017026001 3560249 3567294 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01017026001 3560249 3567294 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01017026001 3560249 3567294 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01017026001 3560249 3567294 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01017026001 3560249 3567294 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01017026001 3560249 3567294 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01017026001 3560249 3567294 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017026001 3560249 3567294 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017026001 3560249 3567294 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017026001 3560249 3567294 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017026001 3560249 3567294 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017026001 3560249 3567294 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035017001 933697 934886 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01035017001 933697 934886 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01033836001 17343092 17354385 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01033836001 17343092 17354385 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005945 6-phosphofructokinase complex A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01033836001 17343092 17354385 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01033836001 17343092 17354385 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01033836001 17343092 17354385 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005945 6-phosphofructokinase complex A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01033836001 17343092 17354385 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01033836001 17343092 17354385 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate. IEA GO:0003872 6-phosphofructokinase activity GSVIVG01033836001 17343092 17354385 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005945 6-phosphofructokinase complex A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known. IEA Catalysis of the reaction: ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate. IEA GO:0003872 6-phosphofructokinase activity GSVIVG01033836001 17343092 17354385 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of the reaction: ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate. IEA GO:0003872 6-phosphofructokinase activity GSVIVG01033836001 17343092 17354385 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate. IEA GO:0003872 6-phosphofructokinase activity GSVIVG01033836001 17343092 17354385 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005945 6-phosphofructokinase complex A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known. IEA Catalysis of the reaction: ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate. IEA GO:0003872 6-phosphofructokinase activity GSVIVG01033836001 17343092 17354385 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of the reaction: ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate. IEA GO:0003872 6-phosphofructokinase activity GSVIVG01033836001 17343092 17354385 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01033836001 17343092 17354385 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005945 6-phosphofructokinase complex A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01033836001 17343092 17354385 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01033836001 17343092 17354385 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01033836001 17343092 17354385 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005945 6-phosphofructokinase complex A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01033836001 17343092 17354385 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01033836001 17343092 17354385 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01033836001 17343092 17354385 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005945 6-phosphofructokinase complex A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01033836001 17343092 17354385 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01033836001 17343092 17354385 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01033836001 17343092 17354385 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005945 6-phosphofructokinase complex A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01033836001 17343092 17354385 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01028710001 19543376 19551472 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028710001 19543376 19551472 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. IEA GO:0004722 protein serine/threonine phosphatase activity GSVIVG01023607001 7927772 7931552 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01018180001 13505485 13506854 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01018180001 13505485 13506854 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01018180001 13505485 13506854 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01021532001 6720512 6726387 GO:0006467 protein thiol-disulfide exchange Oxidation of two organic sulfhydryl groups (thiols) by a disulfide compound to form a disulfide bond. IEA GO:0005789 endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01021532001 6720512 6726387 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005789 endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01021532001 6720512 6726387 GO:0006467 protein thiol-disulfide exchange Oxidation of two organic sulfhydryl groups (thiols) by a disulfide compound to form a disulfide bond. IEA GO:0005789 endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum. IEA Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide. IEA GO:0016671 oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor GSVIVG01021532001 6720512 6726387 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005789 endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum. IEA Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide. IEA GO:0016671 oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor GSVIVG01021532001 6720512 6726387 GO:0006467 protein thiol-disulfide exchange Oxidation of two organic sulfhydryl groups (thiols) by a disulfide compound to form a disulfide bond. IEA GO:0005789 endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01021532001 6720512 6726387 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005789 endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01017977001 5255046 5255439 GSVIVG01014419001 3604727 3606157 GSVIVG01008081001 5974172 5981322 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01008081001 5974172 5981322 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01035792001 4388553 4388836 GSVIVG01034266001 13677499 13693885 GSVIVG01028721001 19455910 19456029 GSVIVG01036399001 4628792 4629164 GSVIVG01036204001 9065178 9065894 GSVIVG01017298001 6470323 6476130 GSVIVG01004482001 38818393 38820335 GSVIVG01016026001 17551931 17553078 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01016026001 17551931 17553078 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01029370001 15591164 15596491 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01020748001 2373423 2379432 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01020748001 2373423 2379432 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01020748001 2373423 2379432 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01020748001 2373423 2379432 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01000968001 22336322 22338766 GSVIVG01037127001 28857272 28859085 GSVIVG01025756001 12172104 12192502 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024583001 8640304 8644470 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01024583001 8640304 8644470 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01024583001 8640304 8644470 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01024583001 8640304 8644470 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01024583001 8640304 8644470 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01024583001 8640304 8644470 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01024583001 8640304 8644470 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024583001 8640304 8644470 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018392001 9862025 9864420 GSVIVG01037232001 17103603 17115903 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01037232001 17103603 17115903 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01037232001 17103603 17115903 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01037232001 17103603 17115903 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01037232001 17103603 17115903 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01037232001 17103603 17115903 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01008216001 4552986 4554238 GSVIVG01018773001 20052330 20057465 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017633001 2164750 2168736 GO:0006464 protein modification process The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. IEA GO:0016881 acid-amino acid ligase activity GSVIVG01025431001 847758 858488 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025431001 847758 858488 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025431001 847758 858488 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025431001 847758 858488 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025431001 847758 858488 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01025431001 847758 858488 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01025431001 847758 858488 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01025431001 847758 858488 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01025431001 847758 858488 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01025431001 847758 858488 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01025431001 847758 858488 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01025431001 847758 858488 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01025431001 847758 858488 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01025431001 847758 858488 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01025431001 847758 858488 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01025431001 847758 858488 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01025431001 847758 858488 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01025431001 847758 858488 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01025431001 847758 858488 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01025431001 847758 858488 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01020685001 3113863 3120425 GO:0006897 endocytosis A type of vesicle-mediated transport in which cells take up external materials or membrane constituents by the invagination of small region of the plasma membrane to form a new membrane-bounded vesicle. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01035715001 3596651 3605452 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01035715001 3596651 3605452 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035715001 3596651 3605452 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01035715001 3596651 3605452 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01037719001 7231712 7233558 GSVIVG01019113001 16630135 16632757 GO:0016311 dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. IEA Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. IEA GO:0004725 protein tyrosine phosphatase activity GSVIVG01019113001 16630135 16632757 GO:0016311 dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. IEA Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. IEA GO:0016791 phosphatase activity GSVIVG01034354001 17614117 17618768 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01003458001 10411753 10412334 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0009317 acetyl-CoA carboxylase complex A protein complex that catalyzes the first step in long-chain fatty acid biosynthesis. For example, in E. coli the complex is heterohexameric and composed of biotin carbonyl carrier protein, biotin carboxylase and the acetate CoA-transferase complex. IEA Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA. IEA GO:0003989 acetyl-CoA carboxylase activity GSVIVG01016266001 5744331 5748409 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01016266001 5744331 5748409 GO:0009725 response to hormone stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01016266001 5744331 5748409 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01016266001 5744331 5748409 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01016266001 5744331 5748409 GO:0009725 response to hormone stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01016266001 5744331 5748409 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01034025001 15755151 15755886 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01034025001 15755151 15755886 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01006445001 26050646 26053673 GSVIVG01023629001 8219044 8219694 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01037880001 6804577 6807417 GSVIVG01020439001 19433699 19434875 GSVIVG01021447001 5461560 5468213 GSVIVG01022402001 19728662 19730803 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals. IEA GO:0008519 ammonium transmembrane transporter activity GSVIVG01022402001 19728662 19730803 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals. IEA GO:0008519 ammonium transmembrane transporter activity GSVIVG01004128001 15114707 15129522 GSVIVG01009782001 11213320 11229319 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01036139001 20237684 20242397 GSVIVG01028359001 6562398 6570091 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01028359001 6562398 6570091 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01028359001 6562398 6570091 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01028359001 6562398 6570091 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026354001 14713070 14730236 GO:0006284 base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. IEA Interacting selectively and non-covalently with damaged DNA. IEA GO:0003684 damaged DNA binding GSVIVG01026354001 14713070 14730236 GO:0006284 base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. IEA Catalysis of the cleavage of the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. IEA GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity GSVIVG01026354001 14713070 14730236 GO:0006284 base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01026354001 14713070 14730236 GO:0006284 base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. IEA Catalysis of the hydrolysis of any N-glycosyl bond. IEA GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds GSVIVG01020841001 1196377 1206544 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01036249001 8101789 8105646 GSVIVG01028435001 7494452 7501710 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01028435001 7494452 7501710 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01028435001 7494452 7501710 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01028435001 7494452 7501710 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01037784001 7842956 7844371 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01012275001 12921043 12928068 GSVIVG01035549001 2209341 2214324 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035549001 2209341 2214324 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01035549001 2209341 2214324 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01015553001 4837042 4857893 GSVIVG01033079001 25581304 25585666 GSVIVG01028846001 18124529 18126065 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01027465001 16517758 16525500 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01012418001 605711 607207 GSVIVG01015096001 1002563 1027008 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01010792001 22635813 22642663 GSVIVG01025598001 13725163 13727096 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01027370001 15578271 15597859 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01027370001 15578271 15597859 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01020563001 4301889 4309591 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01000919001 21897413 21913235 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). IEA GO:0003755 peptidyl-prolyl cis-trans isomerase activity GSVIVG01000919001 21897413 21913235 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. IEA GO:0016853 isomerase activity GSVIVG01004079001 14636425 14650545 GO:0009308 amine metabolic process The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01004079001 14636425 14650545 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01004079001 14636425 14650545 GO:0009308 amine metabolic process The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. IEA Catalysis of the reaction: R-CH2-NH2 + H2O + O2 = R-CHO + NH3 + H2O2. IEA GO:0008131 amine oxidase activity GSVIVG01004079001 14636425 14650545 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: R-CH2-NH2 + H2O + O2 = R-CHO + NH3 + H2O2. IEA GO:0008131 amine oxidase activity GSVIVG01004079001 14636425 14650545 GO:0009308 amine metabolic process The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. IEA Interacting selectively and non-covalently with a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds. IEA GO:0048038 quinone binding GSVIVG01004079001 14636425 14650545 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds. IEA GO:0048038 quinone binding GSVIVG01017011001 3439047 3440507 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01017011001 3439047 3440507 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01017011001 3439047 3440507 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01011413001 29448389 29462308 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01030865001 17922968 17923483 GSVIVG01004730001 15613387 15615916 GSVIVG01009322001 7435495 7436733 GSVIVG01026438001 23627352 23629547 GSVIVG01036582001 18556349 18567244 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Stops, prevents or reduces the activity of a cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004869 cysteine-type endopeptidase inhibitor activity GSVIVG01036582001 18556349 18567244 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Stops, prevents or reduces the activity of a cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004869 cysteine-type endopeptidase inhibitor activity GSVIVG01036582001 18556349 18567244 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036582001 18556349 18567244 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036582001 18556349 18567244 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036582001 18556349 18567244 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028733001 19301911 19308719 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GSVIVG01024224001 40975 48142 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01024224001 40975 48142 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01024224001 40975 48142 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01024224001 40975 48142 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01024224001 40975 48142 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01024224001 40975 48142 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01024061001 1436852 1438669 GSVIVG01010297001 19181576 19184139 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01010297001 19181576 19184139 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01026770001 6776650 6779863 GSVIVG01036214001 8848639 8872320 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025471001 556037 559366 GSVIVG01035156001 12226750 12263844 GSVIVG01036134001 20304527 20311515 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01036134001 20304527 20311515 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01036134001 20304527 20311515 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01027821001 8170774 8171806 GSVIVG01015240001 2056848 2059585 GO:0006644 phospholipid metabolic process The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester. IEA Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. IEA GO:0004623 phospholipase A2 activity GSVIVG01015240001 2056848 2059585 GO:0016042 lipid catabolic process The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. IEA GO:0004623 phospholipase A2 activity GSVIVG01031713001 3675408 3678032 GSVIVG01009912001 12335590 12336595 GSVIVG01027918001 9402569 9419328 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01027918001 9402569 9419328 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01012255001 92040 107832 GSVIVG01024536001 9077586 9081132 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01033755001 18066319 18079943 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01033755001 18066319 18079943 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01033755001 18066319 18079943 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01033755001 18066319 18079943 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01009155001 5617213 5618770 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01020265001 22085747 22086154 GSVIVG01038068001 17401009 17407189 GSVIVG01004252001 37698995 37702449 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01004252001 37698995 37702449 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026206001 14099227 14109182 GO:0042176 regulation of protein catabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0000502 proteasome complex A large multisubunit complex which catalyzes protein degradation. This complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026206001 14099227 14109182 GO:0042176 regulation of protein catabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0000502 proteasome complex A large multisubunit complex which catalyzes protein degradation. This complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core. IEA Modulates the activity of an enzyme. IEA GO:0030234 enzyme regulator activity GSVIVG01022683001 14819757 14824676 GSVIVG01023941001 2298505 2300506 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0031227 intrinsic to endoplasmic reticulum membrane Located in the endoplasmic reticulum membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01023941001 2298505 2300506 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0031227 intrinsic to endoplasmic reticulum membrane Located in the endoplasmic reticulum membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01023941001 2298505 2300506 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0031227 intrinsic to endoplasmic reticulum membrane Located in the endoplasmic reticulum membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01000034001 2945236 2953823 GSVIVG01024425001 2447532 2449745 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with a mating-type factor pheromone to initiate a change in cell activity. IEA GO:0004932 mating-type factor pheromone receptor activity GSVIVG01016345001 4762626 4764570 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016345001 4762626 4764570 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01022376001 19285220 19305046 GSVIVG01012392001 365688 367192 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012392001 365688 367192 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012392001 365688 367192 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01012392001 365688 367192 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01012392001 365688 367192 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01012392001 365688 367192 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01012392001 365688 367192 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01012392001 365688 367192 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01035904001 5614240 5625665 GSVIVG01037512001 12486671 12487509 GSVIVG01025667001 13082726 13085763 GSVIVG01017938001 4894750 4899096 GSVIVG01025238001 2836132 2838151 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion. IEA GO:0004806 triglyceride lipase activity GSVIVG01017167001 4896117 4899140 GO:0006506 GPI anchor biosynthetic process The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol moiety is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate moiety, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage. IEA GO:0005789 endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01017167001 4896117 4899140 GO:0006506 GPI anchor biosynthetic process The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol moiety is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate moiety, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01032449001 27512397 27512588 GSVIVG01023711001 9810538 9850178 GSVIVG01005902001 664189 665014 GSVIVG01033707001 18452454 18458036 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01033707001 18452454 18458036 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01033707001 18452454 18458036 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01033707001 18452454 18458036 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01017086001 4065775 4072649 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01017086001 4065775 4072649 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000550001 7199706 7203084 GSVIVG01021714001 9939900 9949177 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01021714001 9939900 9949177 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01021714001 9939900 9949177 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021714001 9939900 9949177 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01023376001 19195348 19196533 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01023376001 19195348 19196533 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01023376001 19195348 19196533 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01023376001 19195348 19196533 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017105001 4189905 4190834 GSVIVG01032371001 26785071 26786158 GSVIVG01017982001 5265547 5277125 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0016272 prefoldin complex A multisubunit chaperone that acts to delivers unfolded proteins to cytosolic chaperonin. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01022146001 16954197 16965072 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain. IEA GO:0004177 aminopeptidase activity GSVIVG01022146001 16954197 16965072 GO:0009987 cellular process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. IEA Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain. IEA GO:0004177 aminopeptidase activity GSVIVG01022146001 16954197 16965072 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008235 metalloexopeptidase activity GSVIVG01022146001 16954197 16965072 GO:0009987 cellular process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008235 metalloexopeptidase activity GSVIVG01014829001 10275339 10301902 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with transfer RNA. IEA GO:0000049 tRNA binding GSVIVG01014829001 10275339 10301902 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe). IEA GO:0004826 phenylalanine-tRNA ligase activity GSVIVG01014829001 10275339 10301902 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038378001 11439396 11439560 GSVIVG01021543001 6860594 6867191 GSVIVG01013544001 20464718 20481062 GSVIVG01032048001 23198163 23202709 GSVIVG01023286001 20085227 20107699 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01023286001 20085227 20107699 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01017087001 4073327 4086851 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01023146001 22005735 22008903 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01011276001 10430773 10430919 GSVIVG01030668001 13233668 13235118 GSVIVG01014101001 419930 427216 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Functions to initiate or regulate RNA polymerase II transcription. IEA GO:0003702 RNA polymerase II transcription factor activity GSVIVG01014101001 419930 427216 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Functions to initiate or regulate RNA polymerase II transcription. IEA GO:0003702 RNA polymerase II transcription factor activity GSVIVG01014101001 419930 427216 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Functions to initiate or regulate RNA polymerase II transcription. IEA GO:0003702 RNA polymerase II transcription factor activity GSVIVG01014101001 419930 427216 GO:0051090 regulation of transcription factor activity Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Functions to initiate or regulate RNA polymerase II transcription. IEA GO:0003702 RNA polymerase II transcription factor activity GSVIVG01014101001 419930 427216 GO:0051090 regulation of transcription factor activity Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Functions to initiate or regulate RNA polymerase II transcription. IEA GO:0003702 RNA polymerase II transcription factor activity GSVIVG01014101001 419930 427216 GO:0051090 regulation of transcription factor activity Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Functions to initiate or regulate RNA polymerase II transcription. IEA GO:0003702 RNA polymerase II transcription factor activity GSVIVG01014101001 419930 427216 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01014101001 419930 427216 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01014101001 419930 427216 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01014101001 419930 427216 GO:0051090 regulation of transcription factor activity Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01014101001 419930 427216 GO:0051090 regulation of transcription factor activity Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01014101001 419930 427216 GO:0051090 regulation of transcription factor activity Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01014101001 419930 427216 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA IEA GO:0016986 transcription initiation factor activity GSVIVG01014101001 419930 427216 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA IEA GO:0016986 transcription initiation factor activity GSVIVG01014101001 419930 427216 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA IEA GO:0016986 transcription initiation factor activity GSVIVG01014101001 419930 427216 GO:0051090 regulation of transcription factor activity Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA IEA GO:0016986 transcription initiation factor activity GSVIVG01014101001 419930 427216 GO:0051090 regulation of transcription factor activity Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA IEA GO:0016986 transcription initiation factor activity GSVIVG01014101001 419930 427216 GO:0051090 regulation of transcription factor activity Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA IEA GO:0016986 transcription initiation factor activity GSVIVG01009096001 5000081 5001793 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01009096001 5000081 5001793 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01038120001 23617453 23634736 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01038120001 23617453 23634736 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01038120001 23617453 23634736 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01038120001 23617453 23634736 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA GO:0008061 chitin binding GSVIVG01038120001 23617453 23634736 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA GO:0008061 chitin binding GSVIVG01038120001 23617453 23634736 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA GO:0008061 chitin binding GSVIVG01019051001 17354673 17358081 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01019051001 17354673 17358081 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01018361001 10388195 10394634 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01018361001 10388195 10394634 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01018361001 10388195 10394634 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01018361001 10388195 10394634 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01018361001 10388195 10394634 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01018361001 10388195 10394634 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018361001 10388195 10394634 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018361001 10388195 10394634 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018361001 10388195 10394634 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018361001 10388195 10394634 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018361001 10388195 10394634 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01018361001 10388195 10394634 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01018361001 10388195 10394634 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01018361001 10388195 10394634 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01018361001 10388195 10394634 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01013518001 2122820 2123318 Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01013518001 2122820 2123318 Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01016522001 3153073 3175048 GSVIVG01036975001 9373663 9376239 GSVIVG01035580001 2491916 2492832 GSVIVG01028547001 9539484 9543379 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01028547001 9539484 9543379 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01028547001 9539484 9543379 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01028547001 9539484 9543379 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01028547001 9539484 9543379 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008098001 5802051 5808190 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01008098001 5802051 5808190 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01008418001 2288088 2297728 GSVIVG01031399001 19108076 19109963 GSVIVG01017615001 2034777 2035842 GSVIVG01001342001 23762896 23779542 GSVIVG01023708001 9739444 9742072 GSVIVG01012055001 1751426 1755913 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035621001 2757093 2765577 GSVIVG01016363001 4478562 4484576 GSVIVG01038237001 24540364 24543738 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01038237001 24540364 24543738 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01038237001 24540364 24543738 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01038237001 24540364 24543738 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019669001 2339995 2341130 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01019669001 2339995 2341130 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds. IEA GO:0015035 protein disulfide oxidoreductase activity GSVIVG01002356001 34357521 34357775 GSVIVG01033667001 18809103 18811614 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GSVIVG01010295001 19163419 19172097 GSVIVG01036203001 9066647 9067737 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01001139001 22940964 22960324 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01014323001 2630096 2638598 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01014323001 2630096 2638598 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01014738001 9094388 9098703 GO:0008299 isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01020421001 19680046 19684077 GSVIVG01034741001 8817915 8828337 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01034741001 8817915 8828337 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034741001 8817915 8828337 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01034741001 8817915 8828337 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01027345001 16184786 16187800 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01027345001 16184786 16187800 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01004836001 5533775 5534520 GSVIVG01009552001 9335610 9335990 GSVIVG01034138001 14892098 14900648 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01034138001 14892098 14900648 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01034138001 14892098 14900648 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01034138001 14892098 14900648 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01034138001 14892098 14900648 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01034138001 14892098 14900648 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01029786001 14656612 14658350 GSVIVG01025374001 1261666 1263343 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01025374001 1261666 1263343 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01025374001 1261666 1263343 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01025374001 1261666 1263343 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01020536001 4723804 4726534 GSVIVG01030230001 10225447 10226044 GSVIVG01017744001 3075715 3086112 GSVIVG01025751001 12218082 12230964 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025751001 12218082 12230964 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025751001 12218082 12230964 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025751001 12218082 12230964 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025751001 12218082 12230964 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025751001 12218082 12230964 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024252001 234000 242685 GSVIVG01012726001 1036096 1050454 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000261001 20670984 20679844 GSVIVG01008666001 31533 34781 GSVIVG01021332001 4130447 4143823 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01011483001 29971424 29974561 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01011483001 29971424 29974561 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. IEA GO:0008173 RNA methyltransferase activity GSVIVG01033030001 25194663 25204051 GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018623001 12087409 12092067 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01006206001 23672893 23675566 GSVIVG01032553001 28312953 28316327 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01032553001 28312953 28316327 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032553001 28312953 28316327 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01009788001 11268600 11271421 GSVIVG01036081001 20922398 20951032 GO:0016485 protein processing Any protein maturation process achieved by the cleavage of peptide bonds. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01016871001 2143396 2148552 GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016871001 2143396 2148552 GO:0006573 valine metabolic process The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016871001 2143396 2148552 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016871001 2143396 2148552 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016871001 2143396 2148552 GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. IEA Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+. IEA GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity GSVIVG01016871001 2143396 2148552 GO:0006573 valine metabolic process The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid. IEA Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+. IEA GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity GSVIVG01016871001 2143396 2148552 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+. IEA GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity GSVIVG01016871001 2143396 2148552 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+. IEA GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity GSVIVG01016871001 2143396 2148552 GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016871001 2143396 2148552 GO:0006573 valine metabolic process The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016871001 2143396 2148552 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016871001 2143396 2148552 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016871001 2143396 2148552 GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. IEA Catalysis of the reaction: 3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH + H+. IEA GO:0008442 3-hydroxyisobutyrate dehydrogenase activity GSVIVG01016871001 2143396 2148552 GO:0006573 valine metabolic process The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid. IEA Catalysis of the reaction: 3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH + H+. IEA GO:0008442 3-hydroxyisobutyrate dehydrogenase activity GSVIVG01016871001 2143396 2148552 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH + H+. IEA GO:0008442 3-hydroxyisobutyrate dehydrogenase activity GSVIVG01016871001 2143396 2148552 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH + H+. IEA GO:0008442 3-hydroxyisobutyrate dehydrogenase activity GSVIVG01016871001 2143396 2148552 GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016871001 2143396 2148552 GO:0006573 valine metabolic process The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016871001 2143396 2148552 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016871001 2143396 2148552 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016871001 2143396 2148552 GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01016871001 2143396 2148552 GO:0006573 valine metabolic process The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01016871001 2143396 2148552 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01016871001 2143396 2148552 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01028206001 4618758 4622278 GSVIVG01035861001 4977381 4980099 GSVIVG01017975001 5212914 5215828 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01017975001 5212914 5215828 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01017975001 5212914 5215828 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01017975001 5212914 5215828 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01017975001 5212914 5215828 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01017975001 5212914 5215828 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01033794001 17773377 17774702 GSVIVG01032840001 339479 341578 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012489001 13805285 13806679 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012489001 13805285 13806679 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012489001 13805285 13806679 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01036943001 17196382 17198277 GSVIVG01018021001 5537467 5545153 Stops, prevents or reduces the activity of an enzyme. IEA GO:0004857 enzyme inhibitor activity GSVIVG01015654001 15013569 15014879 GSVIVG01035102001 1477611 1481214 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01008728001 1477098 1491666 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01008728001 1477098 1491666 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01008728001 1477098 1491666 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01008728001 1477098 1491666 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01008728001 1477098 1491666 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01008728001 1477098 1491666 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01008728001 1477098 1491666 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008728001 1477098 1491666 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008728001 1477098 1491666 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. IEA GO:0016597 amino acid binding GSVIVG01008728001 1477098 1491666 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. IEA GO:0016597 amino acid binding GSVIVG01002075001 32728223 32734740 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01002075001 32728223 32734740 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01002075001 32728223 32734740 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01002075001 32728223 32734740 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01002075001 32728223 32734740 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01002075001 32728223 32734740 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01002075001 32728223 32734740 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01002075001 32728223 32734740 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01002075001 32728223 32734740 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01002075001 32728223 32734740 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01002075001 32728223 32734740 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01002075001 32728223 32734740 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01002075001 32728223 32734740 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate. IEA GO:0019001 guanyl nucleotide binding GSVIVG01002075001 32728223 32734740 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate. IEA GO:0019001 guanyl nucleotide binding GSVIVG01002075001 32728223 32734740 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate. IEA GO:0019001 guanyl nucleotide binding GSVIVG01002075001 32728223 32734740 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate. IEA GO:0019001 guanyl nucleotide binding GSVIVG01013231001 6499782 6503935 GSVIVG01030951001 19602229 19606440 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01030951001 19602229 19606440 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01030951001 19602229 19606440 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01030951001 19602229 19606440 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01028967001 17017499 17020870 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013996001 8685578 8686327 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01004707001 15400446 15408844 GSVIVG01005987001 23112476 23112679 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01005987001 23112476 23112679 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006655001 27272636 27275960 GSVIVG01016270001 5655713 5663182 GSVIVG01005335001 39718635 39720439 GSVIVG01017824001 3803512 3809392 GSVIVG01034572001 19242564 19274978 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives. IEA GO:0018024 histone-lysine N-methyltransferase activity GSVIVG01008813001 2359940 2406066 GO:0006605 protein targeting The process of targeting specific proteins to particular membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01008813001 2359940 2406066 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01008813001 2359940 2406066 GO:0017038 protein import The directed movement of proteins into a cell or organelle. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01008813001 2359940 2406066 GO:0006605 protein targeting The process of targeting specific proteins to particular membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008813001 2359940 2406066 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008813001 2359940 2406066 GO:0017038 protein import The directed movement of proteins into a cell or organelle. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011061001 1887643 1890890 GSVIVG01033857001 17203436 17209241 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01033857001 17203436 17209241 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01033857001 17203436 17209241 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01013757001 7904820 7907581 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage. IEA GO:0016209 antioxidant activity GSVIVG01013757001 7904820 7907581 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01009844001 11741875 11742625 GSVIVG01029035001 11020640 11049781 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01024052001 1484207 1486257 Functions in the storage of nutritious substrates. IEA GO:0045735 nutrient reservoir activity GSVIVG01010036001 13700912 13706415 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01019412001 450005 457491 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01019412001 450005 457491 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01027698001 14170030 14194374 GSVIVG01023678001 9021690 9022182 GSVIVG01031828001 4741185 4748123 GSVIVG01021568001 7166857 7168010 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion. IEA GO:0004806 triglyceride lipase activity GSVIVG01036328001 3865834 3866388 Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01036328001 3865834 3866388 Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01033670001 18789808 18790780 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01014766001 9406494 9411450 GSVIVG01000057001 3128262 3137145 GSVIVG01025154001 3933701 3940335 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01025154001 3933701 3940335 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01025154001 3933701 3940335 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01025154001 3933701 3940335 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01032561001 28373513 28375989 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01032561001 28373513 28375989 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01032561001 28373513 28375989 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01032561001 28373513 28375989 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009784001 11241271 11245493 GO:0019941 modification-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01009784001 11241271 11245493 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01009784001 11241271 11245493 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01009784001 11241271 11245493 GO:0019941 modification-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01009784001 11241271 11245493 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01009784001 11241271 11245493 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01037175001 28309525 28312657 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01037175001 28309525 28312657 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01033728001 18294779 18298975 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GSVIVG01020090001 10418208 10420151 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01020090001 10418208 10420151 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01014923001 12089404 12090697 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01014923001 12089404 12090697 GO:0006367 transcription initiation from RNA polymerase II promoter A transcription initiation process that results in RNA synthesis by RNA polymerase II. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01014923001 12089404 12090697 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01014923001 12089404 12090697 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Functions to initiate or regulate RNA polymerase II transcription. IEA GO:0003702 RNA polymerase II transcription factor activity GSVIVG01014923001 12089404 12090697 GO:0006367 transcription initiation from RNA polymerase II promoter A transcription initiation process that results in RNA synthesis by RNA polymerase II. IEA Functions to initiate or regulate RNA polymerase II transcription. IEA GO:0003702 RNA polymerase II transcription factor activity GSVIVG01014923001 12089404 12090697 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Functions to initiate or regulate RNA polymerase II transcription. IEA GO:0003702 RNA polymerase II transcription factor activity GSVIVG01014923001 12089404 12090697 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01014923001 12089404 12090697 GO:0006367 transcription initiation from RNA polymerase II promoter A transcription initiation process that results in RNA synthesis by RNA polymerase II. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01014923001 12089404 12090697 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01014923001 12089404 12090697 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01014923001 12089404 12090697 GO:0006367 transcription initiation from RNA polymerase II promoter A transcription initiation process that results in RNA synthesis by RNA polymerase II. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01014923001 12089404 12090697 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01014923001 12089404 12090697 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01014923001 12089404 12090697 GO:0006367 transcription initiation from RNA polymerase II promoter A transcription initiation process that results in RNA synthesis by RNA polymerase II. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01014923001 12089404 12090697 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01014923001 12089404 12090697 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01014923001 12089404 12090697 GO:0006367 transcription initiation from RNA polymerase II promoter A transcription initiation process that results in RNA synthesis by RNA polymerase II. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01014923001 12089404 12090697 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01032620001 2139343 2152266 GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O. IEA GO:0004129 cytochrome-c oxidase activity GSVIVG01002865001 36902498 36902614 GSVIVG01033472001 20411204 20413176 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01033472001 20411204 20413176 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01033472001 20411204 20413176 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01033472001 20411204 20413176 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020029001 11383122 11384462 GSVIVG01000371001 295660 295984 GSVIVG01038182001 24139971 24151147 GSVIVG01020213001 8972483 8973247 GSVIVG01004788001 16130774 16134527 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01004788001 16130774 16134527 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01004788001 16130774 16134527 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01004788001 16130774 16134527 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01004788001 16130774 16134527 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01004788001 16130774 16134527 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01004788001 16130774 16134527 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01004788001 16130774 16134527 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01004788001 16130774 16134527 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01004788001 16130774 16134527 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01016705001 488400 502412 GSVIVG01024116001 971255 975625 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01032021001 23467718 23470754 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032021001 23467718 23470754 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01032021001 23467718 23470754 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01005845001 22211499 22212834 GSVIVG01024872001 6332935 6335895 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01024872001 6332935 6335895 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01024872001 6332935 6335895 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01020532001 4741883 4744882 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01025273001 2555628 2557925 GSVIVG01038628001 21357596 21361368 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01038628001 21357596 21361368 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01038628001 21357596 21361368 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01038628001 21357596 21361368 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01038628001 21357596 21361368 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019583001 1738783 1744976 GSVIVG01032588001 28602116 28607484 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01032588001 28602116 28607484 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016298001 5397270 5399355 GSVIVG01035320001 418734 421550 GO:0007010 cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01035320001 418734 421550 GO:0007010 cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. IEA GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01035320001 418734 421550 GO:0007010 cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01035320001 418734 421550 GO:0030036 actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01035320001 418734 421550 GO:0030036 actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. IEA GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01035320001 418734 421550 GO:0030036 actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01030727001 14611225 14612521 GSVIVG01016080001 18503190 18566999 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01016080001 18503190 18566999 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01016080001 18503190 18566999 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01016080001 18503190 18566999 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016080001 18503190 18566999 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023224001 20955424 20959761 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01023224001 20955424 20959761 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01023224001 20955424 20959761 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01023224001 20955424 20959761 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01023224001 20955424 20959761 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01023224001 20955424 20959761 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023224001 20955424 20959761 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023224001 20955424 20959761 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023224001 20955424 20959761 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023224001 20955424 20959761 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023224001 20955424 20959761 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01023224001 20955424 20959761 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01023224001 20955424 20959761 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01023224001 20955424 20959761 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01023224001 20955424 20959761 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01032286001 14586904 14587286 GSVIVG01029107001 19620906 19622438 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01014491001 4404335 4405377 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014491001 4404335 4405377 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014491001 4404335 4405377 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014491001 4404335 4405377 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008971001 3949804 3956472 GSVIVG01017690001 2672328 2676586 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01017690001 2672328 2676586 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01017690001 2672328 2676586 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01017690001 2672328 2676586 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01017690001 2672328 2676586 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01017690001 2672328 2676586 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01017690001 2672328 2676586 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017690001 2672328 2676586 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017690001 2672328 2676586 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01017690001 2672328 2676586 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01001913001 7152037 7153693 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001913001 7152037 7153693 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001913001 7152037 7153693 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01001913001 7152037 7153693 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01001913001 7152037 7153693 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01001913001 7152037 7153693 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01001913001 7152037 7153693 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001913001 7152037 7153693 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01034895001 16149269 16162689 Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01034895001 16149269 16162689 Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01001298001 5134356 5135658 GO:0006869 lipid transport The directed movement of lipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GSVIVG01015449001 3794479 3797936 The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01011555001 12236135 12239970 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01011555001 12236135 12239970 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011555001 12236135 12239970 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: ATP + D-ribulose 5-phosphate = ADP + D-ribulose 1,5-bisphosphate. IEA GO:0008974 phosphoribulokinase activity GSVIVG01011555001 12236135 12239970 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01011555001 12236135 12239970 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01011555001 12236135 12239970 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01035579001 2484776 2491888 GSVIVG01030568001 6818185 6818676 GSVIVG01011801001 4031776 4035661 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01011801001 4031776 4035661 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01011801001 4031776 4035661 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01011801001 4031776 4035661 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01007770001 9224791 9239797 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01007770001 9224791 9239797 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01007770001 9224791 9239797 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01007770001 9224791 9239797 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01007770001 9224791 9239797 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007770001 9224791 9239797 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007770001 9224791 9239797 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01007770001 9224791 9239797 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01024924001 6003813 6004883 GSVIVG01012956001 11835675 11847570 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01012956001 11835675 11847570 Catalysis of the reaction: ATP + shikimate = ADP + shikimate 3-phosphate. IEA GO:0004765 shikimate kinase activity GSVIVG01012956001 11835675 11847570 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012956001 11835675 11847570 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01023685001 9268596 9272935 GSVIVG01010159001 16552192 16556024 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01010159001 16552192 16556024 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01010159001 16552192 16556024 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01010159001 16552192 16556024 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01010159001 16552192 16556024 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01010159001 16552192 16556024 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031721001 3812818 3816504 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate. IEA GO:0004629 phospholipase C activity GSVIVG01031721001 3812818 3816504 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. IEA GO:0008081 phosphoric diester hydrolase activity GSVIVG01027601001 15135764 15137335 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027601001 15135764 15137335 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027601001 15135764 15137335 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027601001 15135764 15137335 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027601001 15135764 15137335 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01027601001 15135764 15137335 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01027601001 15135764 15137335 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01027601001 15135764 15137335 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01003386001 9761549 9770018 GSVIVG01011185001 7897425 7913124 GO:0009168 purine ribonucleoside monophosphate biosynthetic process The chemical reactions and pathways resulting in the formation of purine ribonucleoside monophosphate, a glycosamine consisting of a purine base linked to a ribose sugar esterified with phosphate on its glycose moiety. IEA Catalysis of the reaction: AMP + H2O = IMP + NH3. IEA GO:0003876 AMP deaminase activity GSVIVG01011185001 7897425 7913124 GO:0009168 purine ribonucleoside monophosphate biosynthetic process The chemical reactions and pathways resulting in the formation of purine ribonucleoside monophosphate, a glycosamine consisting of a purine base linked to a ribose sugar esterified with phosphate on its glycose moiety. IEA Catalysis of the removal of an amino group from a substrate, producing ammonia (NH3). IEA GO:0019239 deaminase activity GSVIVG01017948001 4962405 4965738 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001198001 882592 888350 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01001198001 882592 888350 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01001198001 882592 888350 GO:0008272 sulfate transport The directed movement of sulfate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01001198001 882592 888350 GO:0008272 sulfate transport The directed movement of sulfate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01001198001 882592 888350 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01001198001 882592 888350 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01001198001 882592 888350 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01001198001 882592 888350 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01001198001 882592 888350 GO:0008272 sulfate transport The directed movement of sulfate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01001198001 882592 888350 GO:0008272 sulfate transport The directed movement of sulfate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01001198001 882592 888350 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01001198001 882592 888350 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01012337001 434412 435064 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01012337001 434412 435064 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01035345001 660328 662113 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030183001 10743902 10749427 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01030183001 10743902 10749427 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01030183001 10743902 10749427 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01030183001 10743902 10749427 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029226001 18306162 18324813 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004185 serine-type carboxypeptidase activity GSVIVG01004503001 38863289 38869097 GSVIVG01015371001 3077907 3081776 GSVIVG01035418001 1147885 1166311 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01035418001 1147885 1166311 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01035418001 1147885 1166311 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01035418001 1147885 1166311 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009343001 7566479 7570535 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01003502001 10793950 10802672 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01003502001 10793950 10802672 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01021668001 8998242 9015501 GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021668001 8998242 9015501 GO:0006573 valine metabolic process The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021668001 8998242 9015501 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021668001 8998242 9015501 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021668001 8998242 9015501 GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. IEA Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+. IEA GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity GSVIVG01021668001 8998242 9015501 GO:0006573 valine metabolic process The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid. IEA Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+. IEA GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity GSVIVG01021668001 8998242 9015501 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+. IEA GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity GSVIVG01021668001 8998242 9015501 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+. IEA GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity GSVIVG01021668001 8998242 9015501 GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01021668001 8998242 9015501 GO:0006573 valine metabolic process The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01021668001 8998242 9015501 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01021668001 8998242 9015501 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01021668001 8998242 9015501 GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. IEA Catalysis of the reaction: 3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH + H+. IEA GO:0008442 3-hydroxyisobutyrate dehydrogenase activity GSVIVG01021668001 8998242 9015501 GO:0006573 valine metabolic process The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid. IEA Catalysis of the reaction: 3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH + H+. IEA GO:0008442 3-hydroxyisobutyrate dehydrogenase activity GSVIVG01021668001 8998242 9015501 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH + H+. IEA GO:0008442 3-hydroxyisobutyrate dehydrogenase activity GSVIVG01021668001 8998242 9015501 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH + H+. IEA GO:0008442 3-hydroxyisobutyrate dehydrogenase activity GSVIVG01021668001 8998242 9015501 GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021668001 8998242 9015501 GO:0006573 valine metabolic process The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021668001 8998242 9015501 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021668001 8998242 9015501 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021668001 8998242 9015501 GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01021668001 8998242 9015501 GO:0006573 valine metabolic process The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01021668001 8998242 9015501 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01021668001 8998242 9015501 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01021668001 8998242 9015501 GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01021668001 8998242 9015501 GO:0006573 valine metabolic process The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01021668001 8998242 9015501 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01021668001 8998242 9015501 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01025638001 13420294 13423363 Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01025638001 13420294 13423363 Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01024999001 5387244 5391066 GSVIVG01010086001 15079156 15080294 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019776001 3210384 3214980 GSVIVG01011735001 4707475 4710202 GSVIVG01035085001 1363013 1369931 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion. IEA GO:0004806 triglyceride lipase activity GSVIVG01031461001 18287379 18288448 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01027288001 17146035 17147473 GSVIVG01013179001 7043740 7046954 GSVIVG01029100001 13060765 13061268 GSVIVG01036514001 22892368 22952366 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008493001 1364234 1365304 GSVIVG01037665001 6678933 6680585 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01037665001 6678933 6680585 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01021881001 6071186 6072309 GO:0016068 type I hypersensitivity An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells or basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines. IEA GSVIVG01015204001 1817933 1819418 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01015204001 1817933 1819418 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01015204001 1817933 1819418 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01012046001 1824408 1824470 GSVIVG01034195001 14518513 14520515 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003774001 12535153 12540125 GSVIVG01032914001 24075693 24080124 GSVIVG01026193001 13823548 13827959 GSVIVG01020973001 16101587 16103243 GSVIVG01014130001 649746 649913 GSVIVG01010227001 17946853 17950054 GSVIVG01034722001 8431720 8447363 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01034722001 8431720 8447363 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034722001 8431720 8447363 Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01031956001 5686087 5687004 GSVIVG01001479001 12133777 12135719 GSVIVG01033390001 21003922 21009257 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033390001 21003922 21009257 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01033390001 21003922 21009257 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01016399001 4219177 4222338 GSVIVG01014929001 12181095 12181798 GSVIVG01033331001 21404888 21406789 GSVIVG01023610001 7986586 7989122 GSVIVG01024952001 5717871 5725118 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024952001 5717871 5725118 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: D-glyceraldehyde 3-phosphate = glycerone phosphate. IEA GO:0004807 triose-phosphate isomerase activity GSVIVG01024952001 5717871 5725118 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. IEA GO:0016853 isomerase activity GSVIVG01000834001 2688535 2694704 GSVIVG01028902001 17678464 17678918 GSVIVG01007761001 9334984 9343747 GSVIVG01001897001 6913422 6918611 GSVIVG01015912001 19264109 19321764 GSVIVG01000171001 15847833 15849642 GSVIVG01012427001 692593 703993 GSVIVG01003915001 13543247 13545407 GSVIVG01001978001 5987286 5991878 GSVIVG01010607001 16082633 16085131 GSVIVG01009256001 6723750 6733513 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01009256001 6723750 6733513 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01009256001 6723750 6733513 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01009256001 6723750 6733513 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003683001 12087143 12091138 GSVIVG01030081001 9664311 9670124 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01030081001 9664311 9670124 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01030081001 9664311 9670124 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01030081001 9664311 9670124 GO:0007600 sensory perception The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01030081001 9664311 9670124 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01030081001 9664311 9670124 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01030081001 9664311 9670124 GO:0018298 protein-chromophore linkage The covalent or noncovalent linking of a chromophore to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01030081001 9664311 9670124 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01030081001 9664311 9670124 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01030081001 9664311 9670124 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01030081001 9664311 9670124 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01030081001 9664311 9670124 GO:0007600 sensory perception The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01030081001 9664311 9670124 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01030081001 9664311 9670124 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01030081001 9664311 9670124 GO:0018298 protein-chromophore linkage The covalent or noncovalent linking of a chromophore to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01030081001 9664311 9670124 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01030081001 9664311 9670124 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01030081001 9664311 9670124 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01030081001 9664311 9670124 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01030081001 9664311 9670124 GO:0007600 sensory perception The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01030081001 9664311 9670124 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01030081001 9664311 9670124 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01030081001 9664311 9670124 GO:0018298 protein-chromophore linkage The covalent or noncovalent linking of a chromophore to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01030081001 9664311 9670124 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01030081001 9664311 9670124 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01030081001 9664311 9670124 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01030081001 9664311 9670124 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01030081001 9664311 9670124 GO:0007600 sensory perception The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01030081001 9664311 9670124 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01030081001 9664311 9670124 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01030081001 9664311 9670124 GO:0018298 protein-chromophore linkage The covalent or noncovalent linking of a chromophore to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01030081001 9664311 9670124 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01030081001 9664311 9670124 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030081001 9664311 9670124 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030081001 9664311 9670124 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030081001 9664311 9670124 GO:0007600 sensory perception The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030081001 9664311 9670124 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030081001 9664311 9670124 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030081001 9664311 9670124 GO:0018298 protein-chromophore linkage The covalent or noncovalent linking of a chromophore to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030081001 9664311 9670124 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030081001 9664311 9670124 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A G-protein coupled receptor that responds to incidental electromagnetic radiation, particularly visible light. IEA GO:0008020 G-protein coupled photoreceptor activity GSVIVG01030081001 9664311 9670124 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A G-protein coupled receptor that responds to incidental electromagnetic radiation, particularly visible light. IEA GO:0008020 G-protein coupled photoreceptor activity GSVIVG01030081001 9664311 9670124 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A G-protein coupled receptor that responds to incidental electromagnetic radiation, particularly visible light. IEA GO:0008020 G-protein coupled photoreceptor activity GSVIVG01030081001 9664311 9670124 GO:0007600 sensory perception The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A G-protein coupled receptor that responds to incidental electromagnetic radiation, particularly visible light. IEA GO:0008020 G-protein coupled photoreceptor activity GSVIVG01030081001 9664311 9670124 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A G-protein coupled receptor that responds to incidental electromagnetic radiation, particularly visible light. IEA GO:0008020 G-protein coupled photoreceptor activity GSVIVG01030081001 9664311 9670124 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A G-protein coupled receptor that responds to incidental electromagnetic radiation, particularly visible light. IEA GO:0008020 G-protein coupled photoreceptor activity GSVIVG01030081001 9664311 9670124 GO:0018298 protein-chromophore linkage The covalent or noncovalent linking of a chromophore to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A G-protein coupled receptor that responds to incidental electromagnetic radiation, particularly visible light. IEA GO:0008020 G-protein coupled photoreceptor activity GSVIVG01030081001 9664311 9670124 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A G-protein coupled receptor that responds to incidental electromagnetic radiation, particularly visible light. IEA GO:0008020 G-protein coupled photoreceptor activity GSVIVG01030081001 9664311 9670124 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01030081001 9664311 9670124 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01030081001 9664311 9670124 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01030081001 9664311 9670124 GO:0007600 sensory perception The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01030081001 9664311 9670124 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01030081001 9664311 9670124 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01030081001 9664311 9670124 GO:0018298 protein-chromophore linkage The covalent or noncovalent linking of a chromophore to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01030081001 9664311 9670124 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01007741001 9690038 9700367 GO:0015976 carbon utilization A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbon sources and then activates genes to scavenge the last traces of the primary carbon source and to transport and metabolize alternative carbon sources such as carbon dioxide or carbonic acid. The utilization process begins when the cell or organism detects carbon levels, includes the activation of genes whose products detect, transport or metabolize carbon-containing substances, and ends when carbon is incorporated into the cell or organism's metabolism. IEA Catalysis of the reaction: H2CO3 = CO2 + H2O. IEA GO:0004089 carbonate dehydratase activity GSVIVG01007741001 9690038 9700367 GO:0015976 carbon utilization A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbon sources and then activates genes to scavenge the last traces of the primary carbon source and to transport and metabolize alternative carbon sources such as carbon dioxide or carbonic acid. The utilization process begins when the cell or organism detects carbon levels, includes the activation of genes whose products detect, transport or metabolize carbon-containing substances, and ends when carbon is incorporated into the cell or organism's metabolism. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008943001 3648246 3660889 GSVIVG01037511001 12494946 12500430 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the reaction: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine. IEA GO:0003871 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity GSVIVG01037511001 12494946 12500430 GO:0009086 methionine biosynthetic process The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. IEA Catalysis of the reaction: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine. IEA GO:0003871 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity GSVIVG01037511001 12494946 12500430 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01037511001 12494946 12500430 GO:0009086 methionine biosynthetic process The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01001956001 16094252 16095562 GSVIVG01027497001 16202227 16207483 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01027497001 16202227 16207483 GO:0006614 SRP-dependent cotranslational protein targeting to membrane The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01027497001 16202227 16207483 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01027497001 16202227 16207483 GO:0006614 SRP-dependent cotranslational protein targeting to membrane The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01027497001 16202227 16207483 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027497001 16202227 16207483 GO:0006614 SRP-dependent cotranslational protein targeting to membrane The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027497001 16202227 16207483 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01027497001 16202227 16207483 GO:0006614 SRP-dependent cotranslational protein targeting to membrane The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01027497001 16202227 16207483 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01027497001 16202227 16207483 GO:0006614 SRP-dependent cotranslational protein targeting to membrane The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01027497001 16202227 16207483 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01027497001 16202227 16207483 GO:0006614 SRP-dependent cotranslational protein targeting to membrane The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01027497001 16202227 16207483 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate. IEA GO:0019205 nucleobase, nucleoside, nucleotide kinase activity GSVIVG01027497001 16202227 16207483 GO:0006614 SRP-dependent cotranslational protein targeting to membrane The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. IEA Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate. IEA GO:0019205 nucleobase, nucleoside, nucleotide kinase activity GSVIVG01020982001 15959511 15959702 GSVIVG01036893001 18075928 18088597 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01036893001 18075928 18088597 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01003134001 7537568 7537759 GSVIVG01021407001 5029579 5033522 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01021407001 5029579 5033522 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01021407001 5029579 5033522 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01021407001 5029579 5033522 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01021407001 5029579 5033522 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000313001 2953602 2954584 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01028569001 10001267 10009097 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01005069001 17872950 17875266 GSVIVG01011274001 10380022 10381012 GSVIVG01036607001 19139531 19144240 GSVIVG01032243001 13737423 13751761 GSVIVG01009718001 10749611 10751786 GSVIVG01027672001 14485460 14485784 GSVIVG01009393001 7968542 7971242 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01009393001 7968542 7971242 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01026308001 13328948 13333387 GSVIVG01021602001 7878889 7888205 GSVIVG01001949001 15209476 15209732 GSVIVG01006123001 41873097 41874045 GSVIVG01004060001 594091 595513 GSVIVG01016698001 445796 446630 GSVIVG01008710001 1370768 1382918 GO:0001522 pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01008710001 1370768 1382918 GO:0009451 RNA modification The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01008710001 1370768 1382918 GO:0001522 pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs. IEA Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. IEA GO:0009982 pseudouridine synthase activity GSVIVG01008710001 1370768 1382918 GO:0009451 RNA modification The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. IEA Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. IEA GO:0009982 pseudouridine synthase activity GSVIVG01010734001 21911993 21923514 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010734001 21911993 21923514 GO:0009102 biotin biosynthetic process The chemical reactions and pathways resulting in the formation of biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010734001 21911993 21923514 GO:0051186 cofactor metabolic process The chemical reactions and pathways involving a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010734001 21911993 21923514 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: dethiobiotin + sulfur = biotin. IEA GO:0004076 biotin synthase activity GSVIVG01010734001 21911993 21923514 GO:0009102 biotin biosynthetic process The chemical reactions and pathways resulting in the formation of biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid. IEA Catalysis of the reaction: dethiobiotin + sulfur = biotin. IEA GO:0004076 biotin synthase activity GSVIVG01010734001 21911993 21923514 GO:0051186 cofactor metabolic process The chemical reactions and pathways involving a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. IEA Catalysis of the reaction: dethiobiotin + sulfur = biotin. IEA GO:0004076 biotin synthase activity GSVIVG01010734001 21911993 21923514 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01010734001 21911993 21923514 GO:0009102 biotin biosynthetic process The chemical reactions and pathways resulting in the formation of biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01010734001 21911993 21923514 GO:0051186 cofactor metabolic process The chemical reactions and pathways involving a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01033529001 19981757 19984845 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0008021 synaptic vesicle A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and is secreted these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033529001 19981757 19984845 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01029838001 316804 317643 GSVIVG01020723001 2673099 2674551 GSVIVG01036789001 22522288 22530061 GSVIVG01033492001 20265262 20273077 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01033492001 20265262 20273077 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01033492001 20265262 20273077 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01033492001 20265262 20273077 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01037693001 6956978 6958495 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01037011001 8949485 8950329 GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA GSVIVG01023965001 2088700 2090248 GSVIVG01010298001 19185329 19190687 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01010298001 19185329 19190687 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01010298001 19185329 19190687 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01010298001 19185329 19190687 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01010298001 19185329 19190687 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027153001 17397078 17399513 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01027153001 17397078 17399513 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01027153001 17397078 17399513 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01027153001 17397078 17399513 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01027153001 17397078 17399513 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01027153001 17397078 17399513 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01027153001 17397078 17399513 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01027153001 17397078 17399513 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01027153001 17397078 17399513 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01025005001 5351749 5352367 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025005001 5351749 5352367 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025005001 5351749 5352367 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025005001 5351749 5352367 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025005001 5351749 5352367 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA IEA GO:0016986 transcription initiation factor activity GSVIVG01025005001 5351749 5352367 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA IEA GO:0016986 transcription initiation factor activity GSVIVG01025005001 5351749 5352367 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA IEA GO:0016986 transcription initiation factor activity GSVIVG01025005001 5351749 5352367 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA IEA GO:0016986 transcription initiation factor activity GSVIVG01017195001 5190783 5216301 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01015058001 771978 776094 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: 3-alpha(S)-strictosidine = tryptamine + secologanin. IEA GO:0016844 strictosidine synthase activity GSVIVG01007263001 31114367 31117308 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01007263001 31114367 31117308 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01015482001 4088564 4093204 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01015482001 4088564 4093204 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01015482001 4088564 4093204 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01015482001 4088564 4093204 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01015482001 4088564 4093204 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01015482001 4088564 4093204 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01015482001 4088564 4093204 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01015482001 4088564 4093204 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01015482001 4088564 4093204 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01015482001 4088564 4093204 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01015482001 4088564 4093204 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01015482001 4088564 4093204 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01015482001 4088564 4093204 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01015482001 4088564 4093204 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01015482001 4088564 4093204 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01015799001 17566823 17574771 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01015799001 17566823 17574771 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01015799001 17566823 17574771 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01015799001 17566823 17574771 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018489001 14377559 14381385 GSVIVG01028311001 6007467 6019597 Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor). IEA GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups GSVIVG01031264001 693708 696622 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01029208001 18551192 18553259 GSVIVG01014652001 8231330 8232084 GSVIVG01010376001 19953545 19957705 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01010376001 19953545 19957705 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01010376001 19953545 19957705 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01010376001 19953545 19957705 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01010376001 19953545 19957705 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038270001 24844133 24849912 GO:0008219 cell death A biological process that results in permanent cessation of all vital functions of a cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01038270001 24844133 24849912 GO:0008219 cell death A biological process that results in permanent cessation of all vital functions of a cell. IEA GO:0030077 plasma membrane light-harvesting complex A plasma membrane protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center. Examples of this complex are found in bacterial species. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01038270001 24844133 24849912 GO:0009772 photosynthetic electron transport in photosystem II Electrons move from the primary electron acceptor (Quinone, Q) through a chain of electron transport molecules in the thylakoid membrane until they reach the ultimate electron acceptor of Photosystem II, which is plastocyanin (PC). The electron is then passed to the P700 chlorophyll a molecules of the reaction centre of photosystem I. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01038270001 24844133 24849912 GO:0009772 photosynthetic electron transport in photosystem II Electrons move from the primary electron acceptor (Quinone, Q) through a chain of electron transport molecules in the thylakoid membrane until they reach the ultimate electron acceptor of Photosystem II, which is plastocyanin (PC). The electron is then passed to the P700 chlorophyll a molecules of the reaction centre of photosystem I. IEA GO:0030077 plasma membrane light-harvesting complex A plasma membrane protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center. Examples of this complex are found in bacterial species. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01038270001 24844133 24849912 GO:0019684 photosynthesis, light reaction The light reactions of photosynthesis, which take place in photosystems II and I. Light energy is harvested and used to power the transfer of electrons among a series of electron donors and acceptors. The final electron acceptor is NADP+, which is reduced to NADPH. NADPH generated from light reactions is used in sugar synthesis in dark reactions. Light reactions also generate a proton motive force across the thylakoid membrane, and the proton gradient is used to synthesize ATP. There are two chemical reactions involved in the light reactions: water oxidation in photosystem II, and NADP reduction in photosystem I. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01038270001 24844133 24849912 GO:0019684 photosynthesis, light reaction The light reactions of photosynthesis, which take place in photosystems II and I. Light energy is harvested and used to power the transfer of electrons among a series of electron donors and acceptors. The final electron acceptor is NADP+, which is reduced to NADPH. NADPH generated from light reactions is used in sugar synthesis in dark reactions. Light reactions also generate a proton motive force across the thylakoid membrane, and the proton gradient is used to synthesize ATP. There are two chemical reactions involved in the light reactions: water oxidation in photosystem II, and NADP reduction in photosystem I. IEA GO:0030077 plasma membrane light-harvesting complex A plasma membrane protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center. Examples of this complex are found in bacterial species. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01024332001 1096576 1097799 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024332001 1096576 1097799 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024332001 1096576 1097799 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024332001 1096576 1097799 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024332001 1096576 1097799 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01024332001 1096576 1097799 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01024332001 1096576 1097799 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024332001 1096576 1097799 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01015159001 1448964 1458897 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01015159001 1448964 1458897 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01015159001 1448964 1458897 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01015159001 1448964 1458897 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011018001 2183769 2184041 GSVIVG01020939001 16833128 16833499 GSVIVG01010122001 15828942 15858021 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01010122001 15828942 15858021 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01030139001 10163051 10165706 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01030139001 10163051 10165706 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01030139001 10163051 10165706 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01030139001 10163051 10165706 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01030139001 10163051 10165706 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01030139001 10163051 10165706 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01027453001 16627958 16638187 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01027453001 16627958 16638187 Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. IEA GO:0008171 O-methyltransferase activity GSVIVG01027453001 16627958 16638187 The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01021450001 5509933 5512714 GSVIVG01021251001 3000319 3000979 GSVIVG01013491001 1672655 1730512 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01013491001 1672655 1730512 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01037732001 7328638 7339474 GSVIVG01018096001 6493700 6502148 GSVIVG01008511001 1243376 1246011 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008511001 1243376 1246011 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate. IEA GO:0019205 nucleobase, nucleoside, nucleotide kinase activity GSVIVG01009671001 10346531 10348895 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). IEA GO:0003755 peptidyl-prolyl cis-trans isomerase activity GSVIVG01009671001 10346531 10348895 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). IEA GO:0003755 peptidyl-prolyl cis-trans isomerase activity GSVIVG01009671001 10346531 10348895 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01009671001 10346531 10348895 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01009671001 10346531 10348895 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01009671001 10346531 10348895 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01009671001 10346531 10348895 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01009671001 10346531 10348895 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01009671001 10346531 10348895 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01009671001 10346531 10348895 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01009671001 10346531 10348895 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01009671001 10346531 10348895 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01009671001 10346531 10348895 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01009671001 10346531 10348895 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01017000001 3356763 3359186 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01017000001 3356763 3359186 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01009586001 9669874 9677462 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01036848001 18007181 18008566 GSVIVG01026484001 22853878 22885181 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01026484001 22853878 22885181 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026484001 22853878 22885181 Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01026484001 22853878 22885181 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01017240001 5809165 5820359 GO:0005740 mitochondrial envelope The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O. IEA GO:0004129 cytochrome-c oxidase activity GSVIVG01013145001 7633298 7635209 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013145001 7633298 7635209 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01027065001 18212706 18213083 GSVIVG01021873001 6138470 6224069 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01006129001 41889343 41890560 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006129001 41889343 41890560 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01026602001 21152724 21154968 GO:0015886 heme transport The directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells. IEA GO:0015232 heme transporter activity GSVIVG01026602001 21152724 21154968 GO:0017004 cytochrome complex assembly The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells. IEA GO:0015232 heme transporter activity GSVIVG01005143001 18520442 18521491 GSVIVG01003419001 14826045 14829290 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01003419001 14826045 14829290 GO:0006970 response to osmotic stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01003419001 14826045 14829290 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01003419001 14826045 14829290 GO:0006970 response to osmotic stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01003419001 14826045 14829290 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01003419001 14826045 14829290 GO:0006970 response to osmotic stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01003419001 14826045 14829290 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003419001 14826045 14829290 GO:0006970 response to osmotic stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019119001 16567672 16576903 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01019119001 16567672 16576903 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01019119001 16567672 16576903 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01036935001 17382961 17393010 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01021826001 6811951 6812094 GSVIVG01038254001 24726790 24728778 GSVIVG01025844001 11294684 11297803 GO:0016568 chromatin modification The alteration of DNA or protein in chromatin, which may result in changing the chromatin structure. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01025844001 11294684 11297803 GO:0016568 chromatin modification The alteration of DNA or protein in chromatin, which may result in changing the chromatin structure. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives. IEA GO:0018024 histone-lysine N-methyltransferase activity GSVIVG01012572001 3767785 3768952 GSVIVG01017602001 1929698 1937783 GO:0006614 SRP-dependent cotranslational protein targeting to membrane The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. IEA GO:0048500 signal recognition particle A complex of protein and RNA which facilitates translocation of proteins across membranes. IEA Interacting selectively and non-covalently with 7S RNA, the RNA component of the signal recognition particle (SRP). IEA GO:0008312 7S RNA binding GSVIVG01000955001 22258690 22259169 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) All non-F1 subunits of the mitochondrial hydrogen-transporting ATP synthase, including integral and peripheral mitochondrial inner membrane proteins. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01000955001 22258690 22259169 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01000955001 22258690 22259169 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01000955001 22258690 22259169 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) All non-F1 subunits of the mitochondrial hydrogen-transporting ATP synthase, including integral and peripheral mitochondrial inner membrane proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01000955001 22258690 22259169 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01000955001 22258690 22259169 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01030595001 7028459 7040710 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01030595001 7028459 7040710 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01030595001 7028459 7040710 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01030595001 7028459 7040710 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01001930001 14884883 14886690 GSVIVG01038126001 23676504 23677910 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01038126001 23676504 23677910 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01038126001 23676504 23677910 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01034894001 16148680 16149243 GSVIVG01035819001 4633269 4634426 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01019719001 2722724 2725052 GSVIVG01024995001 5407488 5417476 GO:0051205 protein insertion into membrane The process by which a protein is incorporated into a biological membrane. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01020436001 19485257 19493771 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01032762001 952024 956469 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005850 eukaryotic translation initiation factor 2 complex Complex of three heterogeneous polypeptide chains, that form a ternary complex with initiator methionyl-tRNA and GTP. This ternary complex binds to free 40S subunit, which subsequently binds the 5' end of mRNA. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01032762001 952024 956469 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005850 eukaryotic translation initiation factor 2 complex Complex of three heterogeneous polypeptide chains, that form a ternary complex with initiator methionyl-tRNA and GTP. This ternary complex binds to free 40S subunit, which subsequently binds the 5' end of mRNA. IEA Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. IEA GO:0003743 translation initiation factor activity GSVIVG01024428001 2469223 2469609 GSVIVG01038557001 21844741 21851539 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: ADP-glucose + (1,4)-alpha-D-glucosyl(n) = ADP + (1,4)-alpha-D-glucosyl(n+1). IEA GO:0009011 starch synthase activity GSVIVG01038557001 21844741 21851539 GO:0009250 glucan biosynthetic process The chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues. IEA Catalysis of the reaction: ADP-glucose + (1,4)-alpha-D-glucosyl(n) = ADP + (1,4)-alpha-D-glucosyl(n+1). IEA GO:0009011 starch synthase activity GSVIVG01024270001 438482 453487 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01024270001 438482 453487 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01024270001 438482 453487 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01024270001 438482 453487 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01032291001 14626872 14627084 GSVIVG01027716001 7032952 7035431 GSVIVG01012694001 724228 734265 GSVIVG01029542001 21809462 21819697 GSVIVG01014408001 3443316 3474846 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). IEA GO:0003755 peptidyl-prolyl cis-trans isomerase activity GSVIVG01025620001 13535494 13541021 GSVIVG01031715001 3733846 3735258 GO:0009809 lignin biosynthetic process The chemical reactions and pathways resulting in the formation of lignins, a class of polymers formed by the dehydrogenetive radical polymerization of various phenylpropanoid monomers. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01031715001 3733846 3735258 GO:0009809 lignin biosynthetic process The chemical reactions and pathways resulting in the formation of lignins, a class of polymers formed by the dehydrogenetive radical polymerization of various phenylpropanoid monomers. IEA Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. IEA GO:0008171 O-methyltransferase activity GSVIVG01031715001 3733846 3735258 GO:0009809 lignin biosynthetic process The chemical reactions and pathways resulting in the formation of lignins, a class of polymers formed by the dehydrogenetive radical polymerization of various phenylpropanoid monomers. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01031715001 3733846 3735258 GO:0009809 lignin biosynthetic process The chemical reactions and pathways resulting in the formation of lignins, a class of polymers formed by the dehydrogenetive radical polymerization of various phenylpropanoid monomers. IEA Catalysis of the reaction: S-adenosyl-L-methionine + caffeoyl-CoA = S-adenosyl-L-homocysteine + feruloyl-CoA. IEA GO:0042409 caffeoyl-CoA O-methyltransferase activity GSVIVG01031715001 3733846 3735258 GO:0009809 lignin biosynthetic process The chemical reactions and pathways resulting in the formation of lignins, a class of polymers formed by the dehydrogenetive radical polymerization of various phenylpropanoid monomers. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01007190001 51200 52868 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01007190001 51200 52868 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01007190001 51200 52868 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01006338001 301287 307255 GSVIVG01028021001 3239966 3241350 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01028021001 3239966 3241350 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01017192001 5188637 5188894 GSVIVG01031511001 17781098 17781304 GSVIVG01021646001 8679223 8682910 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01021646001 8679223 8682910 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01021646001 8679223 8682910 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01033190001 9378968 9386209 GSVIVG01011790001 4117218 4124629 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01014125001 600125 606739 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014125001 600125 606739 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010051001 13848112 13855557 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage. IEA GO:0016209 antioxidant activity GSVIVG01010051001 13848112 13855557 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01019778001 3216347 3221693 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01019778001 3216347 3221693 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01019778001 3216347 3221693 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01019778001 3216347 3221693 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01019778001 3216347 3221693 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008210001 4641323 4645945 GSVIVG01027053001 18339430 18341948 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01027053001 18339430 18341948 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01027053001 18339430 18341948 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01027053001 18339430 18341948 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011288001 10661766 10663557 GSVIVG01005147001 18536193 18541084 GSVIVG01030403001 5293490 5294535 GO:0051260 protein homooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01024818001 6649320 6656802 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0000015 phosphopyruvate hydratase complex A multimeric enzyme complex, usually a dimer or an octamer, that catalyzes the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate and water. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01024818001 6649320 6656802 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0000015 phosphopyruvate hydratase complex A multimeric enzyme complex, usually a dimer or an octamer, that catalyzes the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate and water. IEA Catalysis of the reaction: 2-phospho-D-glycerate = phosphoenolpyruvate + H2O. IEA GO:0004634 phosphopyruvate hydratase activity GSVIVG01032515001 28022472 28023779 GSVIVG01029174001 18944267 18946577 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01030433001 5523160 5525376 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030433001 5523160 5525376 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030433001 5523160 5525376 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01030433001 5523160 5525376 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01030433001 5523160 5525376 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01030433001 5523160 5525376 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01030433001 5523160 5525376 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01030433001 5523160 5525376 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01009748001 10950996 10951878 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01009748001 10950996 10951878 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01009748001 10950996 10951878 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01008636001 236874 248571 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01008636001 236874 248571 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01008636001 236874 248571 GO:0019538 protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01008636001 236874 248571 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01008636001 236874 248571 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01008636001 236874 248571 GO:0019538 protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01008636001 236874 248571 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids. IEA GO:0004518 nuclease activity GSVIVG01008636001 236874 248571 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids. IEA GO:0004518 nuclease activity GSVIVG01008636001 236874 248571 GO:0019538 protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids. IEA GO:0004518 nuclease activity GSVIVG01008636001 236874 248571 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01008636001 236874 248571 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01008636001 236874 248571 GO:0019538 protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01008636001 236874 248571 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008636001 236874 248571 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008636001 236874 248571 GO:0019538 protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008636001 236874 248571 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01008636001 236874 248571 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01008636001 236874 248571 GO:0019538 protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01008636001 236874 248571 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01008636001 236874 248571 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01008636001 236874 248571 GO:0019538 protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01008636001 236874 248571 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01008636001 236874 248571 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01008636001 236874 248571 GO:0019538 protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01014015001 9004685 9005356 GSVIVG01020394001 20170738 20172333 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01032097001 22738712 22747739 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01032097001 22738712 22747739 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01006748001 28053723 28062925 GSVIVG01000016001 2828936 2836971 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01000016001 2828936 2836971 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with damaged DNA. IEA GO:0003684 damaged DNA binding GSVIVG01000016001 2828936 2836971 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. IEA GO:0004519 endonuclease activity GSVIVG01016234001 6143131 6153697 GSVIVG01013350001 12534939 12535787 GSVIVG01019696001 2527135 2532638 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01019696001 2527135 2532638 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021376001 4630268 4631980 GSVIVG01025355001 1578883 1582274 GSVIVG01016885001 2248797 2259542 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0000159 protein phosphatase type 2A complex A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit. IEA Modulation of the activity of the enzyme protein phosphatase type 2A. IEA GO:0008601 protein phosphatase type 2A regulator activity GSVIVG01028121001 3991086 4000345 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01019349001 641300 648992 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01008215001 4554837 4563362 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01008215001 4554837 4563362 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01036604001 19071298 19077593 GSVIVG01020026001 11410639 11411089 GSVIVG01005220001 19381610 19382597 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01032662001 1716836 1718836 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01032662001 1716836 1718836 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01013003001 10278100 10293984 GSVIVG01013798001 7490194 7493506 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01013798001 7490194 7493506 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01013798001 7490194 7493506 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01013798001 7490194 7493506 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01013798001 7490194 7493506 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01004797001 143751 176185 GSVIVG01009471001 8641104 8643404 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01009471001 8641104 8643404 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01009471001 8641104 8643404 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01009471001 8641104 8643404 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01023373001 19209522 19214673 GSVIVG01010436001 20564870 20568070 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01010436001 20564870 20568070 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01010436001 20564870 20568070 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032110001 22587974 22596850 GSVIVG01031316001 418571 426137 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01031316001 418571 426137 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01031316001 418571 426137 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019710001 2627588 2631485 GSVIVG01018026001 5577878 5594220 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01006369001 25314419 25317669 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01006369001 25314419 25317669 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01006369001 25314419 25317669 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01027929001 9596528 9599584 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01027929001 9596528 9599584 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01032927001 24225781 24232357 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01001959001 16143331 16146668 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01032819001 501561 504723 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = D-myo-inositol 1,4,5-trisphosphate + diacylglycerol. IEA GO:0004435 phosphoinositide phospholipase C activity GSVIVG01032819001 501561 504723 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = D-myo-inositol 1,4,5-trisphosphate + diacylglycerol. IEA GO:0004435 phosphoinositide phospholipase C activity GSVIVG01032819001 501561 504723 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate. IEA GO:0004629 phospholipase C activity GSVIVG01032819001 501561 504723 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate. IEA GO:0004629 phospholipase C activity GSVIVG01032819001 501561 504723 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. IEA GO:0008081 phosphoric diester hydrolase activity GSVIVG01032819001 501561 504723 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. IEA GO:0008081 phosphoric diester hydrolase activity GSVIVG01020561001 4344861 4346290 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01015053001 735234 743062 GSVIVG01020900001 17569694 17570482 GSVIVG01035633001 2870320 2878007 GSVIVG01019874001 4120663 4122643 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019874001 4120663 4122643 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01017457001 8748031 8752055 GO:0001503 ossification The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance. IEA GSVIVG01017457001 8748031 8752055 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GSVIVG01021362001 4441034 4446492 GSVIVG01029696001 13276642 13300117 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01029696001 13276642 13300117 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01029696001 13276642 13300117 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01029696001 13276642 13300117 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01019562001 1628585 1630021 GSVIVG01035678001 3246967 3250173 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01035678001 3246967 3250173 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01035678001 3246967 3250173 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01035678001 3246967 3250173 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01013428001 531976 535425 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01027755001 7444854 7446921 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01027755001 7444854 7446921 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021052001 14562376 14563204 GSVIVG01016225001 6301122 6305164 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01016225001 6301122 6305164 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01037393001 14459815 14461569 GO:0006777 Mo-molybdopterin cofactor biosynthetic process The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands. IEA GSVIVG01011275001 10412800 10413132 GSVIVG01013042001 9372616 9380457 GO:0001522 pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01013042001 9372616 9380457 GO:0009451 RNA modification The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01013042001 9372616 9380457 GO:0001522 pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs. IEA Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. IEA GO:0009982 pseudouridine synthase activity GSVIVG01013042001 9372616 9380457 GO:0009451 RNA modification The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. IEA Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. IEA GO:0009982 pseudouridine synthase activity GSVIVG01029796001 14820687 14822149 GO:0006869 lipid transport The directed movement of lipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Interacting selectively and non-covalently with a lipid. IEA GO:0008289 lipid binding GSVIVG01028100001 3798651 3800415 GSVIVG01009377001 7881956 7888602 GSVIVG01038746001 369255 376396 GSVIVG01011084001 1738692 1742082 GSVIVG01017632001 2150844 2163230 GSVIVG01038102001 23503053 23506585 GSVIVG01014241001 1859320 1866090 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01033555001 19779867 19798740 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1). IEA GO:0004326 tetrahydrofolylpolyglutamate synthase activity GSVIVG01033555001 19779867 19798740 GO:0009396 folic acid and derivative biosynthetic process The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. IEA Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1). IEA GO:0004326 tetrahydrofolylpolyglutamate synthase activity GSVIVG01033555001 19779867 19798740 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033555001 19779867 19798740 GO:0009396 folic acid and derivative biosynthetic process The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033555001 19779867 19798740 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01033555001 19779867 19798740 GO:0009396 folic acid and derivative biosynthetic process The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01027728001 7206105 7216168 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01027728001 7206105 7216168 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01027728001 7206105 7216168 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01027728001 7206105 7216168 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01027728001 7206105 7216168 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027728001 7206105 7216168 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01027728001 7206105 7216168 Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. IEA GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GSVIVG01010614001 16005953 16008324 GSVIVG01021957001 5090665 5092179 GSVIVG01029408001 16699890 16705592 GSVIVG01006544001 43132319 43134066 GSVIVG01011304001 8205175 8207369 GSVIVG01014629001 7936173 7941661 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01014629001 7936173 7941661 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01014629001 7936173 7941661 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014629001 7936173 7941661 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014629001 7936173 7941661 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01014629001 7936173 7941661 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01014629001 7936173 7941661 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01014629001 7936173 7941661 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01014629001 7936173 7941661 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01014629001 7936173 7941661 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01037871001 6892318 6895634 GSVIVG01025171001 3753364 3754643 GSVIVG01037555001 11470590 11470811 GSVIVG01030891001 18460101 18460196 GSVIVG01008606001 455237 455699 GSVIVG01008586001 696455 707562 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01037844001 7219508 7223633 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01002068001 32646830 32658369 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA IEA GO:0016742 hydroxymethyl-, formyl- and related transferase activity GSVIVG01034770001 21187065 21187730 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033908001 16820658 16820822 GSVIVG01016324001 5101523 5107138 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) All non-F1 subunits of the mitochondrial hydrogen-transporting ATP synthase, including integral and peripheral mitochondrial inner membrane proteins. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01009281001 6930099 6934670 GSVIVG01014905001 11543664 11553113 Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01014905001 11543664 11553113 Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01014905001 11543664 11553113 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01014905001 11543664 11553113 Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01032017001 23510119 23511843 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032017001 23510119 23511843 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01032017001 23510119 23511843 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01009600001 9762403 9784663 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01009600001 9762403 9784663 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01009600001 9762403 9784663 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01009600001 9762403 9784663 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01021654001 8804664 8806457 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021654001 8804664 8806457 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021654001 8804664 8806457 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01021654001 8804664 8806457 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01021654001 8804664 8806457 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01021654001 8804664 8806457 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01021654001 8804664 8806457 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021654001 8804664 8806457 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01014476001 4272423 4275796 GSVIVG01016269001 5665293 5705909 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01016269001 5665293 5705909 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01016269001 5665293 5705909 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01016269001 5665293 5705909 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01023314001 19775934 19777263 GSVIVG01001641001 21678256 21678405 GSVIVG01000822001 625521 627955 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000822001 625521 627955 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000822001 625521 627955 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01000822001 625521 627955 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01000822001 625521 627955 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01000822001 625521 627955 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01006247001 24040951 24041598 GSVIVG01000712001 77994 88805 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. IEA GO:0008080 N-acetyltransferase activity GSVIVG01016170001 7075361 7076427 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01016170001 7075361 7076427 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01015420001 3514242 3515922 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01015420001 3514242 3515922 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01015420001 3514242 3515922 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01015420001 3514242 3515922 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of copper (Cu) ions from one side of a membrane to the other. IEA GO:0005375 copper ion transmembrane transporter activity GSVIVG01015420001 3514242 3515922 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of copper (Cu) ions from one side of a membrane to the other. IEA GO:0005375 copper ion transmembrane transporter activity GSVIVG01015420001 3514242 3515922 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of copper (Cu) ions from one side of a membrane to the other. IEA GO:0005375 copper ion transmembrane transporter activity GSVIVG01015420001 3514242 3515922 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01015420001 3514242 3515922 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01015420001 3514242 3515922 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01015420001 3514242 3515922 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015420001 3514242 3515922 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015420001 3514242 3515922 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015420001 3514242 3515922 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01015420001 3514242 3515922 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01015420001 3514242 3515922 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01015420001 3514242 3515922 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01015420001 3514242 3515922 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01015420001 3514242 3515922 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01010648001 15628315 15630144 Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GSVIVG01010648001 15628315 15630144 Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01022909001 18140735 18149507 GSVIVG01019962001 12284702 12288781 GSVIVG01034672001 7468802 7476194 GO:0031227 intrinsic to endoplasmic reticulum membrane Located in the endoplasmic reticulum membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01025160001 3864900 3870086 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01025160001 3864900 3870086 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01025160001 3864900 3870086 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01025160001 3864900 3870086 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01025160001 3864900 3870086 GO:0008219 cell death A biological process that results in permanent cessation of all vital functions of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01025160001 3864900 3870086 GO:0008219 cell death A biological process that results in permanent cessation of all vital functions of a cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01025160001 3864900 3870086 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025160001 3864900 3870086 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025160001 3864900 3870086 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025160001 3864900 3870086 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025160001 3864900 3870086 GO:0008219 cell death A biological process that results in permanent cessation of all vital functions of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025160001 3864900 3870086 GO:0008219 cell death A biological process that results in permanent cessation of all vital functions of a cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022425001 20000928 20035236 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA GSVIVG01003864001 13000196 13020904 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01003864001 13000196 13020904 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01000650001 20410243 20416433 GO:0006207 'de novo' pyrimidine base biosynthetic process The chemical reactions and pathways resulting in the formation of pyrimidine bases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000650001 20410243 20416433 GO:0006221 pyrimidine nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000650001 20410243 20416433 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000650001 20410243 20416433 GO:0009116 nucleoside metabolic process The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine). IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000650001 20410243 20416433 GO:0006207 'de novo' pyrimidine base biosynthetic process The chemical reactions and pathways resulting in the formation of pyrimidine bases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors. IEA Catalysis of the reaction: orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. IEA GO:0004588 orotate phosphoribosyltransferase activity GSVIVG01000650001 20410243 20416433 GO:0006221 pyrimidine nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. IEA Catalysis of the reaction: orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. IEA GO:0004588 orotate phosphoribosyltransferase activity GSVIVG01000650001 20410243 20416433 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. IEA GO:0004588 orotate phosphoribosyltransferase activity GSVIVG01000650001 20410243 20416433 GO:0009116 nucleoside metabolic process The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine). IEA Catalysis of the reaction: orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. IEA GO:0004588 orotate phosphoribosyltransferase activity GSVIVG01000650001 20410243 20416433 GO:0006207 'de novo' pyrimidine base biosynthetic process The chemical reactions and pathways resulting in the formation of pyrimidine bases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors. IEA Catalysis of the reaction: orotidine 5'-phosphate = UMP + CO2. IEA GO:0004590 orotidine-5'-phosphate decarboxylase activity GSVIVG01000650001 20410243 20416433 GO:0006221 pyrimidine nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. IEA Catalysis of the reaction: orotidine 5'-phosphate = UMP + CO2. IEA GO:0004590 orotidine-5'-phosphate decarboxylase activity GSVIVG01000650001 20410243 20416433 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: orotidine 5'-phosphate = UMP + CO2. IEA GO:0004590 orotidine-5'-phosphate decarboxylase activity GSVIVG01000650001 20410243 20416433 GO:0009116 nucleoside metabolic process The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine). IEA Catalysis of the reaction: orotidine 5'-phosphate = UMP + CO2. IEA GO:0004590 orotidine-5'-phosphate decarboxylase activity GSVIVG01000650001 20410243 20416433 GO:0006207 'de novo' pyrimidine base biosynthetic process The chemical reactions and pathways resulting in the formation of pyrimidine bases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01000650001 20410243 20416433 GO:0006221 pyrimidine nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01000650001 20410243 20416433 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01000650001 20410243 20416433 GO:0009116 nucleoside metabolic process The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine). IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01011506001 30125926 30128269 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01006753001 28093790 28094540 GSVIVG01032303001 14788947 14789388 GSVIVG01021359001 4429965 4431287 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01021359001 4429965 4431287 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01021359001 4429965 4431287 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01021359001 4429965 4431287 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01021359001 4429965 4431287 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01021359001 4429965 4431287 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01021359001 4429965 4431287 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01021359001 4429965 4431287 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01010700001 11975738 11980051 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01010700001 11975738 11980051 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01010700001 11975738 11980051 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010700001 11975738 11980051 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034571001 19280780 19290355 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives. IEA GO:0018024 histone-lysine N-methyltransferase activity GSVIVG01010954001 2683911 2699600 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + dephospho-CoA = ADP + CoA. IEA GO:0004140 dephospho-CoA kinase activity GSVIVG01010954001 2683911 2699600 GO:0015937 coenzyme A biosynthetic process The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + dephospho-CoA = ADP + CoA. IEA GO:0004140 dephospho-CoA kinase activity GSVIVG01010954001 2683911 2699600 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010954001 2683911 2699600 GO:0015937 coenzyme A biosynthetic process The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010954001 2683911 2699600 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of potassium ions (K+) from one side of a membrane to the other. IEA GO:0015079 potassium ion transmembrane transporter activity GSVIVG01010954001 2683911 2699600 GO:0015937 coenzyme A biosynthetic process The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of potassium ions (K+) from one side of a membrane to the other. IEA GO:0015079 potassium ion transmembrane transporter activity GSVIVG01024859001 6398346 6406305 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01024859001 6398346 6406305 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01024859001 6398346 6406305 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01024859001 6398346 6406305 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01019601001 1857989 1860568 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0008076 voltage-gated potassium channel complex A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01019601001 1857989 1860568 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01005729001 21771080 21772059 GSVIVG01037256001 16871317 16875815 GSVIVG01010665001 15378970 15379773 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01010180001 16894943 16897180 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01004942001 21717511 21724801 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01004942001 21717511 21724801 GO:0009725 response to hormone stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01004942001 21717511 21724801 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01004942001 21717511 21724801 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01004942001 21717511 21724801 GO:0009725 response to hormone stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01004942001 21717511 21724801 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01021415001 5081628 5082561 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0008236 serine-type peptidase activity GSVIVG01021415001 5081628 5082561 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0008236 serine-type peptidase activity GSVIVG01025039001 5071970 5078391 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025039001 5071970 5078391 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle. IEA GO:0003917 DNA topoisomerase type I activity GSVIVG01001003001 11299834 11316918 GSVIVG01002254001 33720292 33730204 GSVIVG01025340001 1853936 1868694 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01025340001 1853936 1868694 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01025340001 1853936 1868694 GO:0031408 oxylipin biosynthetic process The chemical reactions and pathways resulting in the formation of any oxylipin, any of a group of biologically active compounds formed by oxidative metabolism of polyunsaturated fatty acids. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01025340001 1853936 1868694 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01025340001 1853936 1868694 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Catalysis of the reaction: linoleate + O2 = (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate. IEA GO:0016165 lipoxygenase activity GSVIVG01025340001 1853936 1868694 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the reaction: linoleate + O2 = (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate. IEA GO:0016165 lipoxygenase activity GSVIVG01025340001 1853936 1868694 GO:0031408 oxylipin biosynthetic process The chemical reactions and pathways resulting in the formation of any oxylipin, any of a group of biologically active compounds formed by oxidative metabolism of polyunsaturated fatty acids. IEA Catalysis of the reaction: linoleate + O2 = (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate. IEA GO:0016165 lipoxygenase activity GSVIVG01025340001 1853936 1868694 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: linoleate + O2 = (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate. IEA GO:0016165 lipoxygenase activity GSVIVG01025340001 1853936 1868694 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025340001 1853936 1868694 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025340001 1853936 1868694 GO:0031408 oxylipin biosynthetic process The chemical reactions and pathways resulting in the formation of any oxylipin, any of a group of biologically active compounds formed by oxidative metabolism of polyunsaturated fatty acids. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025340001 1853936 1868694 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025340001 1853936 1868694 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor. IEA GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen GSVIVG01025340001 1853936 1868694 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor. IEA GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen GSVIVG01025340001 1853936 1868694 GO:0031408 oxylipin biosynthetic process The chemical reactions and pathways resulting in the formation of any oxylipin, any of a group of biologically active compounds formed by oxidative metabolism of polyunsaturated fatty acids. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor. IEA GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen GSVIVG01025340001 1853936 1868694 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor. IEA GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen GSVIVG01025340001 1853936 1868694 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01025340001 1853936 1868694 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01025340001 1853936 1868694 GO:0031408 oxylipin biosynthetic process The chemical reactions and pathways resulting in the formation of any oxylipin, any of a group of biologically active compounds formed by oxidative metabolism of polyunsaturated fatty acids. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01025340001 1853936 1868694 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01025639001 13413639 13415537 GSVIVG01019128001 16461700 16467355 GSVIVG01009131001 5354043 5361249 GSVIVG01005457001 40345581 40346779 GO:0006278 RNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01005457001 40345581 40346779 GO:0006278 RNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. IEA Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time. IEA GO:0003964 RNA-directed DNA polymerase activity GSVIVG01001534001 1103970 1108686 GSVIVG01000088001 3368421 3376823 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008177001 5013390 5014780 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01031411001 18924983 18942363 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01031411001 18924983 18942363 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031411001 18924983 18942363 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01003155001 6154936 6178237 GSVIVG01008429001 2183406 2193451 GO:0000154 rRNA modification The covalent alteration of one or more nucleotides within an rRNA molecule to produce an rRNA molecule with a sequence that differs from that coded genetically. IEA Catalysis of the dimethylation two adjacent A residues in the loop closing the 3'-terminal stem of the 18S rRNA, using S-adenosyl-L-methionine as a methyl donor. IEA GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity GSVIVG01008429001 2183406 2193451 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the dimethylation two adjacent A residues in the loop closing the 3'-terminal stem of the 18S rRNA, using S-adenosyl-L-methionine as a methyl donor. IEA GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity GSVIVG01008429001 2183406 2193451 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the dimethylation two adjacent A residues in the loop closing the 3'-terminal stem of the 18S rRNA, using S-adenosyl-L-methionine as a methyl donor. IEA GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity GSVIVG01008429001 2183406 2193451 GO:0000154 rRNA modification The covalent alteration of one or more nucleotides within an rRNA molecule to produce an rRNA molecule with a sequence that differs from that coded genetically. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01008429001 2183406 2193451 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01008429001 2183406 2193451 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01008429001 2183406 2193451 GO:0000154 rRNA modification The covalent alteration of one or more nucleotides within an rRNA molecule to produce an rRNA molecule with a sequence that differs from that coded genetically. IEA Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule. IEA GO:0008649 rRNA methyltransferase activity GSVIVG01008429001 2183406 2193451 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule. IEA GO:0008649 rRNA methyltransferase activity GSVIVG01008429001 2183406 2193451 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule. IEA GO:0008649 rRNA methyltransferase activity GSVIVG01008429001 2183406 2193451 GO:0000154 rRNA modification The covalent alteration of one or more nucleotides within an rRNA molecule to produce an rRNA molecule with a sequence that differs from that coded genetically. IEA Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid. IEA GO:0008825 cyclopropane-fatty-acyl-phospholipid synthase activity GSVIVG01008429001 2183406 2193451 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid. IEA GO:0008825 cyclopropane-fatty-acyl-phospholipid synthase activity GSVIVG01008429001 2183406 2193451 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid. IEA GO:0008825 cyclopropane-fatty-acyl-phospholipid synthase activity GSVIVG01025040001 5064960 5071957 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025040001 5064960 5071957 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025040001 5064960 5071957 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025040001 5064960 5071957 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025040001 5064960 5071957 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01025040001 5064960 5071957 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01025040001 5064960 5071957 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01025040001 5064960 5071957 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01025040001 5064960 5071957 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01025040001 5064960 5071957 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01037221001 27779526 27785293 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01037221001 27779526 27785293 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01037221001 27779526 27785293 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01037221001 27779526 27785293 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01037221001 27779526 27785293 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01037221001 27779526 27785293 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01037221001 27779526 27785293 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01037221001 27779526 27785293 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01037221001 27779526 27785293 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01037221001 27779526 27785293 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01037221001 27779526 27785293 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01037221001 27779526 27785293 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01037221001 27779526 27785293 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037221001 27779526 27785293 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037221001 27779526 27785293 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037221001 27779526 27785293 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037221001 27779526 27785293 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01037221001 27779526 27785293 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01037221001 27779526 27785293 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01037221001 27779526 27785293 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01027089001 18017446 18020485 GO:0006914 autophagy The process by which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation. IEA GSVIVG01009860001 11876069 11892328 GSVIVG01032945001 24499875 24504223 GSVIVG01029534001 21880901 21883189 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01029534001 21880901 21883189 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01029534001 21880901 21883189 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01029534001 21880901 21883189 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01009599001 9757129 9761902 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01009599001 9757129 9761902 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01009599001 9757129 9761902 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01009599001 9757129 9761902 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01028585001 10246728 10257390 GSVIVG01002335001 34178837 34181195 GSVIVG01036409001 4770893 4774668 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01036409001 4770893 4774668 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01036409001 4770893 4774668 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036409001 4770893 4774668 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031626001 19108996 19111113 GSVIVG01000413001 7676224 7676623 GSVIVG01036213001 8892127 8897163 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01036213001 8892127 8897163 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01036213001 8892127 8897163 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01036213001 8892127 8897163 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01036213001 8892127 8897163 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01036213001 8892127 8897163 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01036213001 8892127 8897163 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01036213001 8892127 8897163 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01036213001 8892127 8897163 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01036213001 8892127 8897163 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036213001 8892127 8897163 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036213001 8892127 8897163 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01005851001 22245890 22247604 GSVIVG01015602001 5478098 5502458 GSVIVG01019392001 264633 274383 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01019392001 264633 274383 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019392001 264633 274383 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate, driving the unwinding of the DNA helix. IEA GO:0004003 ATP-dependent DNA helicase activity GSVIVG01019392001 264633 274383 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01019392001 264633 274383 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019392001 264633 274383 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01024374001 1727130 1728789 GSVIVG01034098001 15157629 15161115 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01009414001 8166275 8168677 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01009414001 8166275 8168677 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01009414001 8166275 8168677 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01009414001 8166275 8168677 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009414001 8166275 8168677 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01034451001 16013346 16029448 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: a phenyl acetate + H2O = a phenol + acetate. IEA GO:0004064 arylesterase activity GSVIVG01034451001 16013346 16029448 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: 3-alpha(S)-strictosidine = tryptamine + secologanin. IEA GO:0016844 strictosidine synthase activity GSVIVG01021374001 4618250 4620232 GSVIVG01018937001 18535065 18535964 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000270001 20843944 20860116 GSVIVG01011047001 1976366 1981277 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01011047001 1976366 1981277 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01011047001 1976366 1981277 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01011047001 1976366 1981277 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01011378001 29164816 29166168 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01011378001 29164816 29166168 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds. IEA GO:0015035 protein disulfide oxidoreductase activity GSVIVG01025140001 4016600 4032119 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GSVIVG01034411001 16635058 16635498 GSVIVG01037026001 8776002 8776646 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01037026001 8776002 8776646 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01013421001 579117 582064 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01013421001 579117 582064 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01032631001 2040250 2041556 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01032631001 2040250 2041556 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01032631001 2040250 2041556 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01032631001 2040250 2041556 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01032631001 2040250 2041556 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA IEA GO:0016986 transcription initiation factor activity GSVIVG01032631001 2040250 2041556 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA IEA GO:0016986 transcription initiation factor activity GSVIVG01032631001 2040250 2041556 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA IEA GO:0016986 transcription initiation factor activity GSVIVG01032631001 2040250 2041556 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA IEA GO:0016986 transcription initiation factor activity GSVIVG01015146001 1354858 1372900 GO:0016459 myosin complex A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01015146001 1354858 1372900 GO:0016459 myosin complex A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. IEA Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate. IEA GO:0003774 motor activity GSVIVG01015146001 1354858 1372900 GO:0016459 myosin complex A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015146001 1354858 1372900 GO:0016459 myosin complex A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01014293001 2373095 2378194 GSVIVG01007821001 8691794 8697959 GSVIVG01034575001 19184319 19184948 GSVIVG01032986001 24836624 24881775 GO:0016568 chromatin modification The alteration of DNA or protein in chromatin, which may result in changing the chromatin structure. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01032986001 24836624 24881775 GO:0016568 chromatin modification The alteration of DNA or protein in chromatin, which may result in changing the chromatin structure. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives. IEA GO:0018024 histone-lysine N-methyltransferase activity GSVIVG01000019001 2846055 2850241 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01000019001 2846055 2850241 GO:0030259 lipid glycosylation Covalent attachment of a glycosyl residue to a lipid molecule. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01000019001 2846055 2850241 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01000019001 2846055 2850241 GO:0030259 lipid glycosylation Covalent attachment of a glycosyl residue to a lipid molecule. IEA Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01011904001 3127797 3132254 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01034907001 1 12798 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01034907001 1 12798 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01016382001 4338548 4342182 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01016382001 4338548 4342182 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01016195001 6825941 6836488 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005945 6-phosphofructokinase complex A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016195001 6825941 6836488 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005945 6-phosphofructokinase complex A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01016195001 6825941 6836488 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005945 6-phosphofructokinase complex A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01016195001 6825941 6836488 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005945 6-phosphofructokinase complex A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known. IEA Catalysis of the reaction: ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate. IEA GO:0003872 6-phosphofructokinase activity GSVIVG01016195001 6825941 6836488 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005945 6-phosphofructokinase complex A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01016195001 6825941 6836488 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005945 6-phosphofructokinase complex A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01017372001 7491982 7514235 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01017372001 7491982 7514235 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01024622001 8305612 8309335 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01024622001 8305612 8309335 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01000464001 8221312 8221934 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01026249001 14849810 14850455 GSVIVG01007880001 7994141 7998739 GO:0019538 protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01007880001 7994141 7998739 GO:0051085 chaperone mediated protein folding requiring cofactor The process of assisting in the correct posttranslational noncovalent assembly of proteins, which is dependent on additional protein cofactors. This process occurs over one or several cycles of nucleotide hydrolysis-dependent binding and release. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01007880001 7994141 7998739 GO:0019538 protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01007880001 7994141 7998739 GO:0051085 chaperone mediated protein folding requiring cofactor The process of assisting in the correct posttranslational noncovalent assembly of proteins, which is dependent on additional protein cofactors. This process occurs over one or several cycles of nucleotide hydrolysis-dependent binding and release. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01007880001 7994141 7998739 GO:0019538 protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007880001 7994141 7998739 GO:0051085 chaperone mediated protein folding requiring cofactor The process of assisting in the correct posttranslational noncovalent assembly of proteins, which is dependent on additional protein cofactors. This process occurs over one or several cycles of nucleotide hydrolysis-dependent binding and release. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007880001 7994141 7998739 GO:0019538 protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01007880001 7994141 7998739 GO:0051085 chaperone mediated protein folding requiring cofactor The process of assisting in the correct posttranslational noncovalent assembly of proteins, which is dependent on additional protein cofactors. This process occurs over one or several cycles of nucleotide hydrolysis-dependent binding and release. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01007880001 7994141 7998739 GO:0019538 protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01007880001 7994141 7998739 GO:0051085 chaperone mediated protein folding requiring cofactor The process of assisting in the correct posttranslational noncovalent assembly of proteins, which is dependent on additional protein cofactors. This process occurs over one or several cycles of nucleotide hydrolysis-dependent binding and release. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01007880001 7994141 7998739 GO:0019538 protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01007880001 7994141 7998739 GO:0051085 chaperone mediated protein folding requiring cofactor The process of assisting in the correct posttranslational noncovalent assembly of proteins, which is dependent on additional protein cofactors. This process occurs over one or several cycles of nucleotide hydrolysis-dependent binding and release. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01008948001 3732846 3738423 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid. IEA GO:0008378 galactosyltransferase activity GSVIVG01036601001 19010351 19011477 Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate. IEA GO:0008146 sulfotransferase activity GSVIVG01000247001 20499207 20504092 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000247001 20499207 20504092 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01031865001 4990921 4991187 GSVIVG01031071001 21825713 21835490 GSVIVG01010244001 18206572 18208242 GSVIVG01038213001 24408619 24418389 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01038213001 24408619 24418389 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01038213001 24408619 24418389 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01038213001 24408619 24418389 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033090001 25646583 25647572 GO:0009186 deoxyribonucleoside diphosphate metabolic process The chemical reactions and pathways involving a deoxyribonucleoside diphosphate, a glycosamine consisting of a base linked to a deoxyribose sugar esterified with diphosphate on its glycose moiety. IEA Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin. IEA GO:0004748 ribonucleoside-diphosphate reductase activity GSVIVG01033090001 25646583 25647572 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin. IEA GO:0004748 ribonucleoside-diphosphate reductase activity GSVIVG01033090001 25646583 25647572 GO:0009186 deoxyribonucleoside diphosphate metabolic process The chemical reactions and pathways involving a deoxyribonucleoside diphosphate, a glycosamine consisting of a base linked to a deoxyribose sugar esterified with diphosphate on its glycose moiety. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033090001 25646583 25647572 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033090001 25646583 25647572 GO:0009186 deoxyribonucleoside diphosphate metabolic process The chemical reactions and pathways involving a deoxyribonucleoside diphosphate, a glycosamine consisting of a base linked to a deoxyribose sugar esterified with diphosphate on its glycose moiety. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01033090001 25646583 25647572 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01029297001 17376939 17380909 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01029297001 17376939 17380909 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01029297001 17376939 17380909 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029297001 17376939 17380909 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029297001 17376939 17380909 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029297001 17376939 17380909 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029297001 17376939 17380909 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01029297001 17376939 17380909 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01035001001 808814 816916 GSVIVG01037352001 15304498 15306529 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Stops, prevents or reduces the activity of an enzyme. IEA GO:0004857 enzyme inhibitor activity GSVIVG01037352001 15304498 15306529 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the reaction: pectin + n H2O = n methanol + pectate. IEA GO:0030599 pectinesterase activity GSVIVG01008686001 1214782 1221660 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01008686001 1214782 1221660 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01008686001 1214782 1221660 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01008686001 1214782 1221660 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01008686001 1214782 1221660 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008686001 1214782 1221660 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008686001 1214782 1221660 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01008686001 1214782 1221660 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01002014001 32277131 32283199 GO:0051260 protein homooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01018849001 19272760 19321893 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010823001 23045985 23046335 GSVIVG01013639001 2026304 2027844 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01013282001 5684001 5689314 GSVIVG01026207001 14127881 14133989 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01026207001 14127881 14133989 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01024197001 415127 427415 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: 2 farnesyl diphosphate = diphosphate + presqualene diphosphate. IEA GO:0004310 farnesyl-diphosphate farnesyltransferase activity GSVIVG01024197001 415127 427415 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: 2 farnesyl diphosphate = diphosphate + presqualene diphosphate. IEA GO:0004310 farnesyl-diphosphate farnesyltransferase activity GSVIVG01024197001 415127 427415 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01024197001 415127 427415 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01005140001 18506051 18507034 GSVIVG01038661001 21140127 21142774 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01001467001 21251443 21255669 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01001467001 21251443 21255669 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01001467001 21251443 21255669 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01032964001 24650212 24651690 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01032964001 24650212 24651690 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01017308001 6583359 6602443 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01017308001 6583359 6602443 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01017308001 6583359 6602443 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017308001 6583359 6602443 Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01034635001 13618650 13619840 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GSVIVG01009427001 8266901 8269503 GSVIVG01021781001 7481088 7518279 GO:0006357 regulation of transcription from RNA polymerase II promoter Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. IEA GO:0016592 mediator complex A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. IEA Functions to mediate the interaction of transcriptional activators with the RNA polymerase II-general RNA polymerase II transcription factor complex. IEA GO:0016455 RNA polymerase II transcription mediator activity GSVIVG01015353001 2919023 2922654 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01030261001 9772720 9780613 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030261001 9772720 9780613 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030261001 9772720 9780613 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01030261001 9772720 9780613 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01021576001 7355580 7366827 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01021576001 7355580 7366827 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01035319001 415712 418685 GSVIVG01009129001 5350194 5352136 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01009129001 5350194 5352136 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01009129001 5350194 5352136 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01009129001 5350194 5352136 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025054001 4923621 4933645 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01007566001 11927365 11927493 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001285001 4983356 4986675 GSVIVG01008293001 3562314 3570422 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005578 proteinaceous extracellular matrix A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus. IEA GSVIVG01034848001 22618200 22638670 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01034848001 22618200 22638670 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Catalysis of the transfer of a nucleotidyl group to a reactant. IEA GO:0016779 nucleotidyltransferase activity GSVIVG01001713001 12623028 12624155 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01001713001 12623028 12624155 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000266001 20722095 20732642 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01000266001 20722095 20732642 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01000266001 20722095 20732642 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000266001 20722095 20732642 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000266001 20722095 20732642 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000266001 20722095 20732642 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000266001 20722095 20732642 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01000266001 20722095 20732642 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01035550001 2217047 2222194 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01020697001 3041043 3042142 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004197 cysteine-type endopeptidase activity GSVIVG01020697001 3041043 3042142 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01020697001 3041043 3042142 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01020697001 3041043 3042142 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01030114001 9979763 9982923 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01016905001 2435991 2440975 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01016905001 2435991 2440975 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. IEA GO:0008173 RNA methyltransferase activity GSVIVG01008365001 2821874 2869660 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01008365001 2821874 2869660 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01008365001 2821874 2869660 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01008365001 2821874 2869660 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with double-stranded RNA. IEA GO:0003725 double-stranded RNA binding GSVIVG01008365001 2821874 2869660 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01008365001 2821874 2869660 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008365001 2821874 2869660 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01008365001 2821874 2869660 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01024887001 6228818 6230046 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024887001 6228818 6230046 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024887001 6228818 6230046 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024887001 6228818 6230046 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01024887001 6228818 6230046 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01024887001 6228818 6230046 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01024887001 6228818 6230046 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024887001 6228818 6230046 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024887001 6228818 6230046 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024887001 6228818 6230046 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01024887001 6228818 6230046 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01024887001 6228818 6230046 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01024887001 6228818 6230046 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024887001 6228818 6230046 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024887001 6228818 6230046 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01012926001 13671504 13671863 Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides. IEA GO:0004866 endopeptidase inhibitor activity GSVIVG01009197001 6040226 6058566 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01009197001 6040226 6058566 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01009197001 6040226 6058566 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01034661001 12944312 12945291 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01009625001 10015414 10021454 GSVIVG01009271001 6843128 6848829 GSVIVG01020681001 3143476 3144989 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01020681001 3143476 3144989 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022473001 3488246 3489925 GSVIVG01026819001 20234161 20254735 GSVIVG01020222001 8886792 8891553 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01020222001 8886792 8891553 Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01011792001 4104654 4112761 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01015514001 4357927 4360489 GSVIVG01003724001 7425205 7437817 GSVIVG01026802001 7472216 7473936 GSVIVG01030196001 10607887 10609176 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01030196001 10607887 10609176 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01030196001 10607887 10609176 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01030196001 10607887 10609176 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01028791001 18755873 18768116 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01028791001 18755873 18768116 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028791001 18755873 18768116 Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01028791001 18755873 18768116 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01034681001 7578564 7590705 GO:0006370 mRNA capping Addition of the 7-methylguanosine cap to the 5' end of a nascent messenger RNA transcript. IEA GSVIVG01019720001 2727566 2744486 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01007943001 7311470 7311955 GSVIVG01030921001 18998496 19017088 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01023133001 22240726 22251337 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01023133001 22240726 22251337 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01023133001 22240726 22251337 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). IEA GO:0016769 transferase activity, transferring nitrogenous groups GSVIVG01023133001 22240726 22251337 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01018597001 12533320 12534870 GSVIVG01010702001 12045099 12045833 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010702001 12045099 12045833 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01009595001 9734478 9737305 GSVIVG01011714001 4852705 4856279 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the transfer of a phosphate group from one position to another within a single molecule. IEA GO:0016868 intramolecular transferase activity, phosphotransferases GSVIVG01003799001 210820 241249 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01003799001 210820 241249 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01037226001 27705194 27721484 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000432001 7919322 7931527 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01000432001 7919322 7931527 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01000432001 7919322 7931527 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01000432001 7919322 7931527 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01000432001 7919322 7931527 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01000432001 7919322 7931527 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01000432001 7919322 7931527 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000432001 7919322 7931527 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014703001 8786718 8790827 GSVIVG01023067001 15932861 15936398 GSVIVG01011749001 4565334 4574753 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01011749001 4565334 4574753 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01011749001 4565334 4574753 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli. IEA GO:0004707 MAP kinase activity GSVIVG01011749001 4565334 4574753 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01011749001 4565334 4574753 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012432001 719747 730094 GSVIVG01005033001 17442923 17443706 GSVIVG01036006001 7027361 7101962 Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01036006001 7027361 7101962 Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01029288001 17464806 17471999 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01029288001 17464806 17471999 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01029288001 17464806 17471999 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015934 large ribosomal subunit The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01029288001 17464806 17471999 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0031361 integral to thylakoid membrane Penetrating at least one phospholipid bilayer of a thylakoid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01029288001 17464806 17471999 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01029288001 17464806 17471999 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01029288001 17464806 17471999 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0015934 large ribosomal subunit The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01029288001 17464806 17471999 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0031361 integral to thylakoid membrane Penetrating at least one phospholipid bilayer of a thylakoid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01029288001 17464806 17471999 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01029288001 17464806 17471999 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01029288001 17464806 17471999 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015934 large ribosomal subunit The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01029288001 17464806 17471999 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0031361 integral to thylakoid membrane Penetrating at least one phospholipid bilayer of a thylakoid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01029288001 17464806 17471999 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01029288001 17464806 17471999 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01029288001 17464806 17471999 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0015934 large ribosomal subunit The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01029288001 17464806 17471999 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0031361 integral to thylakoid membrane Penetrating at least one phospholipid bilayer of a thylakoid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01029288001 17464806 17471999 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01029288001 17464806 17471999 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01029288001 17464806 17471999 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015934 large ribosomal subunit The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01029288001 17464806 17471999 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0031361 integral to thylakoid membrane Penetrating at least one phospholipid bilayer of a thylakoid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01029288001 17464806 17471999 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01029288001 17464806 17471999 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01029288001 17464806 17471999 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0015934 large ribosomal subunit The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01029288001 17464806 17471999 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0031361 integral to thylakoid membrane Penetrating at least one phospholipid bilayer of a thylakoid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01029288001 17464806 17471999 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01029288001 17464806 17471999 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01029288001 17464806 17471999 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015934 large ribosomal subunit The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01029288001 17464806 17471999 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0031361 integral to thylakoid membrane Penetrating at least one phospholipid bilayer of a thylakoid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01029288001 17464806 17471999 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01029288001 17464806 17471999 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01029288001 17464806 17471999 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0015934 large ribosomal subunit The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01029288001 17464806 17471999 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0031361 integral to thylakoid membrane Penetrating at least one phospholipid bilayer of a thylakoid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01029288001 17464806 17471999 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01029288001 17464806 17471999 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01029288001 17464806 17471999 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015934 large ribosomal subunit The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01029288001 17464806 17471999 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0031361 integral to thylakoid membrane Penetrating at least one phospholipid bilayer of a thylakoid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01029288001 17464806 17471999 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01029288001 17464806 17471999 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01029288001 17464806 17471999 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0015934 large ribosomal subunit The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01029288001 17464806 17471999 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0031361 integral to thylakoid membrane Penetrating at least one phospholipid bilayer of a thylakoid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01017039001 3694803 3699990 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01021294001 3605540 3609570 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01009371001 7846237 7853155 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01009371001 7846237 7853155 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01009371001 7846237 7853155 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01009371001 7846237 7853155 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01008691001 1239330 1246388 GSVIVG01017912001 4600909 4604073 GSVIVG01030137001 10136864 10146009 GSVIVG01026414001 23798589 23816120 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01026414001 23798589 23816120 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026414001 23798589 23816120 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026414001 23798589 23816120 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003295001 14252269 14256617 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01003295001 14252269 14256617 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01008237001 4277599 4305670 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01008237001 4277599 4305670 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01009641001 10127883 10134515 GSVIVG01024772001 7085859 7092222 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01024772001 7085859 7092222 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024772001 7085859 7092222 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01019070001 17127763 17132342 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GSVIVG01030633001 7326438 7330722 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01030633001 7326438 7330722 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030862001 17878298 17878940 GSVIVG01030239001 10017028 10027242 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01030239001 10017028 10027242 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01011977001 2467165 2475404 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01011977001 2467165 2475404 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01011977001 2467165 2475404 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01019645001 2172173 2178520 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GSVIVG01023751001 10644801 10644926 GSVIVG01020195001 9205057 9206501 GSVIVG01023959001 2128296 2140641 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01010570001 16520750 16521936 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010570001 16520750 16521936 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010570001 16520750 16521936 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01010570001 16520750 16521936 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01035146001 1857660 1860023 GSVIVG01019738001 2853793 2870798 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019738001 2853793 2870798 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01019954001 12434639 12437491 GSVIVG01035069001 1288591 1289336 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GSVIVG01035069001 1288591 1289336 GO:0009607 response to biotic stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism. IEA GSVIVG01002112001 33003133 33006617 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01002112001 33003133 33006617 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01002112001 33003133 33006617 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01002112001 33003133 33006617 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01001163001 1158694 1161585 GSVIVG01016609001 2451725 2454785 GSVIVG01030637001 7349620 7350420 GSVIVG01004511001 38947183 38951986 GSVIVG01031432001 18652672 18658561 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01010601001 16131009 16138470 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01010601001 16131009 16138470 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01036891001 18133522 18139501 Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GSVIVG01036891001 18133522 18139501 Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01013438001 474843 476501 GSVIVG01017597001 11126768 11147975 GSVIVG01038021001 16398332 16399024 GSVIVG01029444001 22832344 22833942 GSVIVG01012172001 785438 792711 GSVIVG01017012001 3448473 3449824 GSVIVG01014534001 4909146 4917818 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014534001 4909146 4917818 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014534001 4909146 4917818 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014534001 4909146 4917818 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014534001 4909146 4917818 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014534001 4909146 4917818 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014534001 4909146 4917818 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014534001 4909146 4917818 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014534001 4909146 4917818 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01014534001 4909146 4917818 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01020039001 11257108 11257345 GSVIVG01018852001 19238929 19241455 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GSVIVG01011824001 3829462 3833628 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: 2 5-aminolevulinate = porphobilinogen + 2 H2O. IEA GO:0004655 porphobilinogen synthase activity GSVIVG01011824001 3829462 3833628 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: 2 5-aminolevulinate = porphobilinogen + 2 H2O. IEA GO:0004655 porphobilinogen synthase activity GSVIVG01011824001 3829462 3833628 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: 2 5-aminolevulinate = porphobilinogen + 2 H2O. IEA GO:0004655 porphobilinogen synthase activity GSVIVG01011824001 3829462 3833628 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: 2 5-aminolevulinate = porphobilinogen + 2 H2O. IEA GO:0004655 porphobilinogen synthase activity GSVIVG01011824001 3829462 3833628 GO:0033014 tetrapyrrole biosynthetic process The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: 2 5-aminolevulinate = porphobilinogen + 2 H2O. IEA GO:0004655 porphobilinogen synthase activity GSVIVG01011824001 3829462 3833628 GO:0033014 tetrapyrrole biosynthetic process The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: 2 5-aminolevulinate = porphobilinogen + 2 H2O. IEA GO:0004655 porphobilinogen synthase activity GSVIVG01011824001 3829462 3833628 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: 2 5-aminolevulinate = porphobilinogen + 2 H2O. IEA GO:0004655 porphobilinogen synthase activity GSVIVG01011824001 3829462 3833628 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: 2 5-aminolevulinate = porphobilinogen + 2 H2O. IEA GO:0004655 porphobilinogen synthase activity GSVIVG01011824001 3829462 3833628 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01011824001 3829462 3833628 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01011824001 3829462 3833628 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01011824001 3829462 3833628 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01011824001 3829462 3833628 GO:0033014 tetrapyrrole biosynthetic process The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01011824001 3829462 3833628 GO:0033014 tetrapyrrole biosynthetic process The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01011824001 3829462 3833628 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01011824001 3829462 3833628 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01011824001 3829462 3833628 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01011824001 3829462 3833628 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01011824001 3829462 3833628 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01011824001 3829462 3833628 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01011824001 3829462 3833628 GO:0033014 tetrapyrrole biosynthetic process The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01011824001 3829462 3833628 GO:0033014 tetrapyrrole biosynthetic process The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01011824001 3829462 3833628 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01011824001 3829462 3833628 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01016485001 3477279 3479749 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016485001 3477279 3479749 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. IEA GO:0004722 protein serine/threonine phosphatase activity GSVIVG01015982001 16771085 16779925 GSVIVG01035541001 2149606 2152937 GSVIVG01033277001 21935664 21941417 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: ATP + protoporphyrin IX + Mg2+ + H2O = ADP + phosphate + Mg-protoporphyrin IX + 2 H+. IEA GO:0016851 magnesium chelatase activity GSVIVG01033277001 21935664 21941417 GO:0015995 chlorophyll biosynthetic process The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors. IEA Catalysis of the reaction: ATP + protoporphyrin IX + Mg2+ + H2O = ADP + phosphate + Mg-protoporphyrin IX + 2 H+. IEA GO:0016851 magnesium chelatase activity GSVIVG01011066001 1856423 1857615 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01026007001 25936491 25946775 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01026007001 25936491 25946775 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01026007001 25936491 25946775 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01026007001 25936491 25946775 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025683001 12972420 12973144 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01016596001 2535388 2539967 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01016596001 2535388 2539967 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01016596001 2535388 2539967 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01016596001 2535388 2539967 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01016596001 2535388 2539967 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01016596001 2535388 2539967 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016596001 2535388 2539967 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016596001 2535388 2539967 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016596001 2535388 2539967 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016596001 2535388 2539967 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016596001 2535388 2539967 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01016596001 2535388 2539967 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01016596001 2535388 2539967 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01016596001 2535388 2539967 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01016596001 2535388 2539967 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01016506001 3326988 3327071 GSVIVG01025304001 2261465 2273045 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025304001 2261465 2273045 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01025304001 2261465 2273045 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01025304001 2261465 2273045 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01025304001 2261465 2273045 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009777001 11184161 11185662 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01009777001 11184161 11185662 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01009777001 11184161 11185662 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01009777001 11184161 11185662 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01021537001 6759592 6760132 GSVIVG01034260001 13647514 13653413 GSVIVG01009078001 4760150 4762878 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009078001 4760150 4762878 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009078001 4760150 4762878 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01009078001 4760150 4762878 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01009078001 4760150 4762878 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01009078001 4760150 4762878 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01009078001 4760150 4762878 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01009078001 4760150 4762878 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01037590001 10340147 10360304 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01037590001 10340147 10360304 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01027502001 16172343 16173612 GSVIVG01017581001 10959197 10961616 GSVIVG01008701001 1307369 1311229 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008701001 1307369 1311229 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008701001 1307369 1311229 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008701001 1307369 1311229 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008701001 1307369 1311229 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008701001 1307369 1311229 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008701001 1307369 1311229 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008701001 1307369 1311229 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01035626001 2785955 2788687 GSVIVG01031221001 1068220 1069677 GSVIVG01019124001 16527065 16528699 GSVIVG01015005001 385442 395146 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01015005001 385442 395146 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01015005001 385442 395146 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01015005001 385442 395146 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01019407001 412568 416019 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019407001 412568 416019 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019407001 412568 416019 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01019407001 412568 416019 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01014553001 5068259 5077130 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01014553001 5068259 5077130 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01014553001 5068259 5077130 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01037400001 14369714 14371491 GO:0006777 Mo-molybdopterin cofactor biosynthetic process The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands. IEA GSVIVG01015551001 4818734 4820928 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other. IEA GO:0005337 nucleoside transmembrane transporter activity GSVIVG01003162001 6078670 6081676 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01003162001 6078670 6081676 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01003162001 6078670 6081676 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01003162001 6078670 6081676 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01003162001 6078670 6081676 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024628001 8261792 8262673 GSVIVG01013455001 320109 322487 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008053001 6215992 6217587 Catalysis of the eliminative cleavage of pectate to give oligosaccharides with 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their non-reducing ends. IEA GO:0030570 pectate lyase activity GSVIVG01015181001 1613091 1616720 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031016001 20989003 20997527 GSVIVG01003847001 12807924 12810121 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01003847001 12807924 12810121 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01037053001 8326557 8335645 GSVIVG01006519001 42774515 42775292 GSVIVG01009189001 5920512 5929041 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01009189001 5920512 5929041 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with double-stranded RNA. IEA GO:0003725 double-stranded RNA binding GSVIVG01019073001 17057537 17060722 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004185 serine-type carboxypeptidase activity GSVIVG01027456001 16592819 16601584 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01024935001 5918386 5927879 GSVIVG01016654001 146722 157241 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01016654001 146722 157241 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01016654001 146722 157241 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01016654001 146722 157241 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016654001 146722 157241 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037866001 6975809 6984113 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01037866001 6975809 6984113 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01037866001 6975809 6984113 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. IEA GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GSVIVG01037866001 6975809 6984113 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species. IEA GO:0031418 L-ascorbic acid binding GSVIVG01036124001 20408629 20410809 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01036124001 20408629 20410809 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01036124001 20408629 20410809 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01006509001 42538038 42538597 GSVIVG01003596001 11093316 11100159 GSVIVG01031661001 19746230 19750105 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01031661001 19746230 19750105 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01031661001 19746230 19750105 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01031661001 19746230 19750105 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01031661001 19746230 19750105 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01031661001 19746230 19750105 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01031661001 19746230 19750105 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031661001 19746230 19750105 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031661001 19746230 19750105 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031661001 19746230 19750105 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024853001 6472078 6475330 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GSVIVG01034340001 17832316 17835531 GSVIVG01020516001 4921820 4923524 GSVIVG01013928001 6885070 6887648 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0031361 integral to thylakoid membrane Penetrating at least one phospholipid bilayer of a thylakoid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01013928001 6885070 6887648 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0031361 integral to thylakoid membrane Penetrating at least one phospholipid bilayer of a thylakoid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01013928001 6885070 6887648 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0031361 integral to thylakoid membrane Penetrating at least one phospholipid bilayer of a thylakoid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01034782001 21471547 21496811 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01034782001 21471547 21496811 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01034782001 21471547 21496811 GO:0009306 protein secretion The controlled release of proteins from a cell or group of cells. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01034782001 21471547 21496811 GO:0009306 protein secretion The controlled release of proteins from a cell or group of cells. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01034782001 21471547 21496811 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA A ligand-dependent receptor found in the nucleus of the cell. IEA GO:0004879 ligand-dependent nuclear receptor activity GSVIVG01034782001 21471547 21496811 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A ligand-dependent receptor found in the nucleus of the cell. IEA GO:0004879 ligand-dependent nuclear receptor activity GSVIVG01034782001 21471547 21496811 GO:0009306 protein secretion The controlled release of proteins from a cell or group of cells. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA A ligand-dependent receptor found in the nucleus of the cell. IEA GO:0004879 ligand-dependent nuclear receptor activity GSVIVG01034782001 21471547 21496811 GO:0009306 protein secretion The controlled release of proteins from a cell or group of cells. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A ligand-dependent receptor found in the nucleus of the cell. IEA GO:0004879 ligand-dependent nuclear receptor activity GSVIVG01034782001 21471547 21496811 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01034782001 21471547 21496811 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01034782001 21471547 21496811 GO:0009306 protein secretion The controlled release of proteins from a cell or group of cells. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01034782001 21471547 21496811 GO:0009306 protein secretion The controlled release of proteins from a cell or group of cells. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01034782001 21471547 21496811 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01034782001 21471547 21496811 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01034782001 21471547 21496811 GO:0009306 protein secretion The controlled release of proteins from a cell or group of cells. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01034782001 21471547 21496811 GO:0009306 protein secretion The controlled release of proteins from a cell or group of cells. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01004809001 77037 83420 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01004809001 77037 83420 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01004809001 77037 83420 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01004809001 77037 83420 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01032078001 22923584 22929726 GSVIVG01004792001 79688 80398 GSVIVG01004017001 1343540 1346246 GSVIVG01012997001 10444000 10444299 GSVIVG01020809001 1701089 1713743 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01000228001 16271611 16275676 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01000228001 16271611 16275676 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end. IEA GO:0004527 exonuclease activity GSVIVG01033762001 18040568 18045148 GSVIVG01015516001 4382031 4385728 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01014170001 1054217 1059738 GSVIVG01036644001 19663460 19668809 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). IEA GO:0003755 peptidyl-prolyl cis-trans isomerase activity GSVIVG01036644001 19663460 19668809 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. IEA GO:0016853 isomerase activity GSVIVG01018036001 5718042 5720567 GSVIVG01017163001 4874378 4879053 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017163001 4874378 4879053 Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01004567001 39078580 39082835 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01004567001 39078580 39082835 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01004567001 39078580 39082835 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01004567001 39078580 39082835 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01004567001 39078580 39082835 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. IEA GO:0016597 amino acid binding GSVIVG01004567001 39078580 39082835 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. IEA GO:0016597 amino acid binding GSVIVG01033332001 21399685 21404533 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033332001 21399685 21404533 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0008236 serine-type peptidase activity GSVIVG01025269001 2573382 2575343 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01018103001 6568685 6573863 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030127 COPII vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018103001 6568685 6573863 GO:0006888 ER to Golgi vesicle-mediated transport The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi. IEA GO:0030127 COPII vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01005169001 18917320 18931672 GSVIVG01015892001 19001153 19002719 GSVIVG01038617001 21447165 21450532 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01038617001 21447165 21450532 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01029407001 16524939 16681799 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01029407001 16524939 16681799 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01029407001 16524939 16681799 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01029407001 16524939 16681799 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01029407001 16524939 16681799 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01029407001 16524939 16681799 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01017928001 4782869 4784874 GSVIVG01001805001 25964912 25970428 GO:0009116 nucleoside metabolic process The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine). IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001805001 25964912 25970428 GO:0009116 nucleoside metabolic process The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine). IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01024190001 480460 480785 GSVIVG01026274001 15258938 15267708 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018091001 6397285 6408271 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01009422001 8220838 8227069 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01009422001 8220838 8227069 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01009422001 8220838 8227069 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01009422001 8220838 8227069 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01009422001 8220838 8227069 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009422001 8220838 8227069 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01031178001 1451251 1472812 GSVIVG01019061001 17227365 17237592 GSVIVG01011878001 3341192 3354024 GSVIVG01000094001 3462334 3464866 GSVIVG01027888001 9075798 9076764 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01025883001 27491474 27505772 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01015472001 3988735 3992370 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015472001 3988735 3992370 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015472001 3988735 3992370 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015472001 3988735 3992370 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01015472001 3988735 3992370 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01015472001 3988735 3992370 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01015472001 3988735 3992370 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01015472001 3988735 3992370 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01015472001 3988735 3992370 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01006639001 27204872 27211688 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01001296001 5125430 5126116 GO:0006869 lipid transport The directed movement of lipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GSVIVG01025167001 3803463 3804860 GSVIVG01013341001 12367770 12383059 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01013341001 12367770 12383059 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01013341001 12367770 12383059 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01013341001 12367770 12383059 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028780001 18902673 18905654 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01009140001 5470374 5476297 GO:0010038 response to metal ion A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus. IEA GSVIVG01026984001 18821560 18826926 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01026984001 18821560 18826926 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01026984001 18821560 18826926 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01026984001 18821560 18826926 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli. IEA GO:0004707 MAP kinase activity GSVIVG01026984001 18821560 18826926 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01026984001 18821560 18826926 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026984001 18821560 18826926 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01026984001 18821560 18826926 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01011813001 3907609 3908170 GSVIVG01020286001 21874071 21876155 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01007582001 11674724 11676881 GSVIVG01022599001 5765191 5772713 Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters. IEA GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters GSVIVG01017422001 8307444 8310426 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: ATP + glycerol = ADP + glycerol 3-phosphate. IEA GO:0004370 glycerol kinase activity GSVIVG01017422001 8307444 8310426 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA Catalysis of the reaction: ATP + glycerol = ADP + glycerol 3-phosphate. IEA GO:0004370 glycerol kinase activity GSVIVG01017422001 8307444 8310426 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01017422001 8307444 8310426 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01017422001 8307444 8310426 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01017422001 8307444 8310426 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01017422001 8307444 8310426 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01017422001 8307444 8310426 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01001636001 21620325 21622681 GSVIVG01030914001 18906136 18918830 GO:0042773 ATP synthesis coupled electron transport The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. IEA GO:0008137 NADH dehydrogenase (ubiquinone) activity GSVIVG01030914001 18906136 18918830 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. IEA GO:0008137 NADH dehydrogenase (ubiquinone) activity GSVIVG01030914001 18906136 18918830 GO:0042773 ATP synthesis coupled electron transport The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01030914001 18906136 18918830 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01030914001 18906136 18918830 GO:0042773 ATP synthesis coupled electron transport The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01030914001 18906136 18918830 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01030914001 18906136 18918830 GO:0042773 ATP synthesis coupled electron transport The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016651 oxidoreductase activity, acting on NADH or NADPH GSVIVG01030914001 18906136 18918830 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016651 oxidoreductase activity, acting on NADH or NADPH GSVIVG01030914001 18906136 18918830 GO:0042773 ATP synthesis coupled electron transport The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01030914001 18906136 18918830 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01024106001 1009627 1014673 GO:0006621 protein retention in ER lumen The retention in the endoplasmic reticulum (ER) lumen of soluble resident proteins. Sorting receptors retrieve proteins with ER localization signals, such as KDEL and HDEL sequences or some transmembrane domains, that have escaped to the cis-Golgi network and return them to the ER. Abnormally folded proteins and unassembled subunits are also selectively retained in the ER. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with an endoplasmic reticulum (ER) retention sequence, a specific peptide sequence that ensures a protein is retained within the ER. IEA GO:0046923 ER retention sequence binding GSVIVG01026892001 19605120 19612387 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01026892001 19605120 19612387 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01026892001 19605120 19612387 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01026892001 19605120 19612387 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026892001 19605120 19612387 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024670001 7922065 7927503 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01033533001 19953117 19956166 GSVIVG01014093001 329777 330095 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01014093001 329777 330095 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01001272001 4882099 4884289 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01001272001 4882099 4884289 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01001272001 4882099 4884289 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01001272001 4882099 4884289 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01001272001 4882099 4884289 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01001272001 4882099 4884289 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01011247001 10064474 10068473 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01011247001 10064474 10068473 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01035312001 324760 362232 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01035312001 324760 362232 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01035312001 324760 362232 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01035312001 324760 362232 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035312001 324760 362232 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020678001 3173094 3175003 GSVIVG01016486001 3472012 3472116 GSVIVG01035367001 794663 810293 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01035367001 794663 810293 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01035367001 794663 810293 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01035367001 794663 810293 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035367001 794663 810293 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023406001 12453010 12457170 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023406001 12453010 12457170 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023406001 12453010 12457170 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023406001 12453010 12457170 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023406001 12453010 12457170 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023406001 12453010 12457170 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023406001 12453010 12457170 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01023406001 12453010 12457170 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01011927001 2951539 2951847 GSVIVG01038149001 23897674 23899101 GO:0006631 fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01038149001 23897674 23899101 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01038149001 23897674 23899101 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01038149001 23897674 23899101 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01038149001 23897674 23899101 GO:0006631 fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of the reaction: stearoyl-[acyl-carrier protein] + reduced acceptor + O2 = oleoyl-[acyl-carrier protein] + acceptor + H2O. The enzyme requires ferredoxin. IEA GO:0045300 acyl-[acyl-carrier-protein] desaturase activity GSVIVG01038149001 23897674 23899101 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of the reaction: stearoyl-[acyl-carrier protein] + reduced acceptor + O2 = oleoyl-[acyl-carrier protein] + acceptor + H2O. The enzyme requires ferredoxin. IEA GO:0045300 acyl-[acyl-carrier-protein] desaturase activity GSVIVG01038149001 23897674 23899101 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of the reaction: stearoyl-[acyl-carrier protein] + reduced acceptor + O2 = oleoyl-[acyl-carrier protein] + acceptor + H2O. The enzyme requires ferredoxin. IEA GO:0045300 acyl-[acyl-carrier-protein] desaturase activity GSVIVG01038149001 23897674 23899101 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of the reaction: stearoyl-[acyl-carrier protein] + reduced acceptor + O2 = oleoyl-[acyl-carrier protein] + acceptor + H2O. The enzyme requires ferredoxin. IEA GO:0045300 acyl-[acyl-carrier-protein] desaturase activity GSVIVG01038149001 23897674 23899101 GO:0006631 fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01038149001 23897674 23899101 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01038149001 23897674 23899101 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01038149001 23897674 23899101 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01007638001 10957677 10965768 GO:0006414 translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Functions in chain elongation during polypeptide synthesis at the ribosome. IEA GO:0003746 translation elongation factor activity GSVIVG01007638001 10957677 10965768 GO:0006414 translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01007638001 10957677 10965768 GO:0006414 translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01035049001 1171455 1172443 GSVIVG01025148001 3981582 3982378 GSVIVG01024447001 2697504 2699391 GSVIVG01022510001 4202929 4205774 GSVIVG01014448001 3860468 3862735 GSVIVG01035241001 11138082 11139316 GSVIVG01024341001 1193976 1198442 GO:0006014 D-ribose metabolic process The chemical reactions and pathways involving D-ribose (ribo-pentose). As beta-D-ribofuranose, D-ribose forms the glycose moiety of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12. IEA Catalysis of the reaction: ATP + D-ribose = ADP + D-ribose 5-phosphate. IEA GO:0004747 ribokinase activity GSVIVG01008561001 867655 868764 GSVIVG01035655001 3049489 3050612 GSVIVG01015686001 15596924 15598147 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01015686001 15596924 15598147 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022418001 19932281 19935873 GSVIVG01018331001 10927634 10933721 GSVIVG01023081001 15630472 15638712 GSVIVG01018559001 13389627 13390390 GSVIVG01021903001 5832150 5833787 GSVIVG01017741001 3059660 3060076 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01017741001 3059660 3060076 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01017741001 3059660 3060076 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01017741001 3059660 3060076 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01002667001 35798953 35802265 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01002667001 35798953 35802265 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01013247001 6287439 6318076 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01013247001 6287439 6318076 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01013247001 6287439 6318076 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01013247001 6287439 6318076 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013247001 6287439 6318076 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01013247001 6287439 6318076 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01013247001 6287439 6318076 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01036133001 20319193 20320586 GSVIVG01036876001 18345602 18354600 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01036876001 18345602 18354600 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036876001 18345602 18354600 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01036876001 18345602 18354600 Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01036876001 18345602 18354600 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01036876001 18345602 18354600 Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01036544001 23257452 23277219 GSVIVG01022378001 19332541 19333071 GSVIVG01005205001 19187554 19189902 GSVIVG01010096001 15304653 15307940 GSVIVG01012414001 596220 599111 GSVIVG01008034001 6455525 6456835 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01021658001 8828270 8833865 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007448001 31999267 32001479 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01007448001 31999267 32001479 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01007448001 31999267 32001479 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01007448001 31999267 32001479 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01003316001 8998030 8998963 GSVIVG01010902001 15960220 15968165 GSVIVG01012224001 442141 445496 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036046001 21487228 21505244 GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01036046001 21487228 21505244 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01000869001 3230942 3231212 GSVIVG01029512001 22094433 22097730 GSVIVG01014368001 3076914 3091784 GO:0008219 cell death A biological process that results in permanent cessation of all vital functions of a cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01031291001 585872 587037 GSVIVG01026947001 19173601 19175767 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01026947001 19173601 19175767 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01026947001 19173601 19175767 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01026947001 19173601 19175767 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01015109001 1103689 1109096 GSVIVG01031629001 19191451 19193008 GSVIVG01018057001 5878823 5883144 GO:0000103 sulfate assimilation The pathways by which inorganic sulfate is processed and incorporated into sulfated compounds. IEA Catalysis of the reaction: ATP + sulfate = diphosphate + adenylylsulfate. IEA GO:0004781 sulfate adenylyltransferase (ATP) activity GSVIVG01008617001 369677 378037 GSVIVG01034574001 19199496 19202915 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01034574001 19199496 19202915 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01034574001 19199496 19202915 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01034574001 19199496 19202915 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01034574001 19199496 19202915 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01034574001 19199496 19202915 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01034574001 19199496 19202915 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01034574001 19199496 19202915 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01034574001 19199496 19202915 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01034574001 19199496 19202915 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01031883001 5135429 5145069 GSVIVG01031468001 18238838 18241459 GSVIVG01016949001 2894642 2896484 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01016949001 2894642 2896484 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01033243001 22236658 22247426 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01013538001 20344508 20353316 GSVIVG01023960001 2124583 2127705 GSVIVG01015256001 2146058 2151370 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01015256001 2146058 2151370 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01015256001 2146058 2151370 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008237 metallopeptidase activity GSVIVG01015256001 2146058 2151370 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008237 metallopeptidase activity GSVIVG01015256001 2146058 2151370 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01015256001 2146058 2151370 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01015256001 2146058 2151370 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01015256001 2146058 2151370 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01016734001 745759 752329 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016734001 745759 752329 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01032441001 27429817 27443141 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01032441001 27429817 27443141 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01032441001 27429817 27443141 GO:0030488 tRNA methylation The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01032441001 27429817 27443141 GO:0030488 tRNA methylation The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01032441001 27429817 27443141 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01032441001 27429817 27443141 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01032441001 27429817 27443141 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methyladenine. IEA GO:0016429 tRNA (adenine-N1-)-methyltransferase activity GSVIVG01032441001 27429817 27443141 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methyladenine. IEA GO:0016429 tRNA (adenine-N1-)-methyltransferase activity GSVIVG01032441001 27429817 27443141 GO:0030488 tRNA methylation The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methyladenine. IEA GO:0016429 tRNA (adenine-N1-)-methyltransferase activity GSVIVG01032441001 27429817 27443141 GO:0030488 tRNA methylation The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methyladenine. IEA GO:0016429 tRNA (adenine-N1-)-methyltransferase activity GSVIVG01032441001 27429817 27443141 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methyladenine. IEA GO:0016429 tRNA (adenine-N1-)-methyltransferase activity GSVIVG01032441001 27429817 27443141 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methyladenine. IEA GO:0016429 tRNA (adenine-N1-)-methyltransferase activity GSVIVG01010153001 16474190 16475881 GSVIVG01035031001 1038893 1042624 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009445001 8424001 8427407 GSVIVG01015862001 18554585 18570746 GSVIVG01023346001 19491818 19495618 GSVIVG01006543001 43112528 43114136 GSVIVG01022917001 18086734 18090627 GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01022917001 18086734 18090627 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01022917001 18086734 18090627 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01022917001 18086734 18090627 GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. IEA Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+. IEA GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity GSVIVG01022917001 18086734 18090627 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+. IEA GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity GSVIVG01022917001 18086734 18090627 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+. IEA GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity GSVIVG01022917001 18086734 18090627 GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01022917001 18086734 18090627 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01022917001 18086734 18090627 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01022917001 18086734 18090627 GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022917001 18086734 18090627 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022917001 18086734 18090627 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022917001 18086734 18090627 GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01022917001 18086734 18090627 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01022917001 18086734 18090627 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01026580001 21427667 21430968 GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01026580001 21427667 21430968 GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01026580001 21427667 21430968 GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01026580001 21427667 21430968 GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01026580001 21427667 21430968 GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026580001 21427667 21430968 GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024606001 8486133 8488080 GSVIVG01015185001 1635733 1636098 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0031361 integral to thylakoid membrane Penetrating at least one phospholipid bilayer of a thylakoid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01015185001 1635733 1636098 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0031361 integral to thylakoid membrane Penetrating at least one phospholipid bilayer of a thylakoid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01015185001 1635733 1636098 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0031361 integral to thylakoid membrane Penetrating at least one phospholipid bilayer of a thylakoid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01032096001 22748092 22756748 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032096001 22748092 22756748 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01017483001 9151871 9153235 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009522 photosystem I A photosystem that contains an iron-sulfur reaction center associated with accessory pigments and electron carriers. In cyanobacteria and chloroplasts, photosystem I functions as a light-dependent plastocyanin-ferredoxin oxidoreductase, transferring electrons from plastocyanin to ferredoxin; in photosynthetic bacteria that have only a single type I photosystem, such as the green sulfur bacteria, electrons can go either to ferredoxin (Fd) -> NAD+ or to menaquinone (MK) -> Cytb/FeS -> Cytc555 -> photosystem I (cyclic photophosphorylation). IEA GSVIVG01017483001 9151871 9153235 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009579 thylakoid A membranous cellular structure that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the plasma membrane. In eukaryotes they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation. IEA GSVIVG01017483001 9151871 9153235 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01024181001 533514 544910 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01024181001 533514 544910 GO:0016570 histone modification The covalent alteration of one or more amino acid residues within a histone protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01024181001 533514 544910 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01024181001 533514 544910 GO:0016570 histone modification The covalent alteration of one or more amino acid residues within a histone protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01024181001 533514 544910 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01024181001 533514 544910 GO:0016570 histone modification The covalent alteration of one or more amino acid residues within a histone protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01011587001 6214541 6217236 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01035346001 663813 668638 GSVIVG01037687001 6892724 6895966 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01033282001 21903351 21905752 GSVIVG01013881001 5891859 5894009 GO:0016568 chromatin modification The alteration of DNA or protein in chromatin, which may result in changing the chromatin structure. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01013881001 5891859 5894009 GO:0016568 chromatin modification The alteration of DNA or protein in chromatin, which may result in changing the chromatin structure. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives. IEA GO:0018024 histone-lysine N-methyltransferase activity GSVIVG01003262001 8549325 8552271 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01003262001 8549325 8552271 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01003262001 8549325 8552271 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003262001 8549325 8552271 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003262001 8549325 8552271 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01003262001 8549325 8552271 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01001160001 1167451 1178629 GSVIVG01032386001 26869402 26872316 GO:0006487 protein amino acid N-linked glycosylation A protein amino acid glycosylation process in which a sugar unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-mannosyl-R = UDP + 4-(N-acetyl-beta-D-glucosaminyl)-beta-D-mannosyl-R. IEA GO:0003830 beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity GSVIVG01001021001 20146548 20148253 GSVIVG01032901001 23946686 23949803 GSVIVG01020237001 8695847 8697185 GSVIVG01024351001 1304279 1316294 GO:0006364 rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. IEA GO:0032040 small-subunit processome A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins. IEA GSVIVG01009227001 6439226 6441781 GSVIVG01012203001 586453 588903 Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum. IEA GO:0003993 acid phosphatase activity GSVIVG01012203001 586453 588903 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01010933001 15426928 15427845 GSVIVG01024598001 8548466 8549597 GSVIVG01011388001 29266013 29275249 GSVIVG01028702001 19665908 19669286 GSVIVG01023771001 10879650 10881672 GSVIVG01015287001 2407867 2419914 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01015287001 2407867 2419914 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01015287001 2407867 2419914 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01015287001 2407867 2419914 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01015287001 2407867 2419914 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030696001 13723130 13723924 GSVIVG01030274001 9633508 9635000 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01034143001 14855512 14860992 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008168001 5149856 5151301 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01036664001 19977742 19994533 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GSVIVG01025596001 13739571 13747201 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025596001 13739571 13747201 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025596001 13739571 13747201 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025596001 13739571 13747201 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025596001 13739571 13747201 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025596001 13739571 13747201 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025596001 13739571 13747201 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01025596001 13739571 13747201 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01025596001 13739571 13747201 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01025596001 13739571 13747201 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01025596001 13739571 13747201 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01025596001 13739571 13747201 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01030107001 9904808 9908324 GSVIVG01005153001 18688799 18690274 GSVIVG01037569001 11065726 11067846 GSVIVG01017467001 8840075 8843249 GSVIVG01017765001 3254195 3263072 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01005871001 22386933 22389023 GSVIVG01007624001 11135753 11137581 GSVIVG01031861001 4959953 4969008 Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01031861001 4959953 4969008 Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01031861001 4959953 4969008 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01031861001 4959953 4969008 Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01030925001 19108490 19110627 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01030925001 19108490 19110627 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015867001 18642183 18642380 GSVIVG01029946001 1966603 1991366 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. IEA GO:0003743 translation initiation factor activity GSVIVG01029946001 1966603 1991366 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. IEA GO:0003743 translation initiation factor activity GSVIVG01029946001 1966603 1991366 GO:0006413 translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. IEA GO:0003743 translation initiation factor activity GSVIVG01029946001 1966603 1991366 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. IEA GO:0003743 translation initiation factor activity GSVIVG01029946001 1966603 1991366 GO:0045941 positive regulation of transcription Any cellular process that activates or increases the frequency, rate or extent of transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. IEA GO:0003743 translation initiation factor activity GSVIVG01029946001 1966603 1991366 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. IEA GO:0003743 translation initiation factor activity GSVIVG01029946001 1966603 1991366 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029946001 1966603 1991366 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029946001 1966603 1991366 GO:0006413 translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029946001 1966603 1991366 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029946001 1966603 1991366 GO:0045941 positive regulation of transcription Any cellular process that activates or increases the frequency, rate or extent of transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029946001 1966603 1991366 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029946001 1966603 1991366 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01029946001 1966603 1991366 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01029946001 1966603 1991366 GO:0006413 translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01029946001 1966603 1991366 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01029946001 1966603 1991366 GO:0045941 positive regulation of transcription Any cellular process that activates or increases the frequency, rate or extent of transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01029946001 1966603 1991366 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01029946001 1966603 1991366 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any transcription regulator activity required for initiation or upregulation of transcription. IEA GO:0016563 transcription activator activity GSVIVG01029946001 1966603 1991366 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any transcription regulator activity required for initiation or upregulation of transcription. IEA GO:0016563 transcription activator activity GSVIVG01029946001 1966603 1991366 GO:0006413 translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any transcription regulator activity required for initiation or upregulation of transcription. IEA GO:0016563 transcription activator activity GSVIVG01029946001 1966603 1991366 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any transcription regulator activity required for initiation or upregulation of transcription. IEA GO:0016563 transcription activator activity GSVIVG01029946001 1966603 1991366 GO:0045941 positive regulation of transcription Any cellular process that activates or increases the frequency, rate or extent of transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any transcription regulator activity required for initiation or upregulation of transcription. IEA GO:0016563 transcription activator activity GSVIVG01029946001 1966603 1991366 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any transcription regulator activity required for initiation or upregulation of transcription. IEA GO:0016563 transcription activator activity GSVIVG01029946001 1966603 1991366 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01029946001 1966603 1991366 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01029946001 1966603 1991366 GO:0006413 translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01029946001 1966603 1991366 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01029946001 1966603 1991366 GO:0045941 positive regulation of transcription Any cellular process that activates or increases the frequency, rate or extent of transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01029946001 1966603 1991366 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01029946001 1966603 1991366 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01029946001 1966603 1991366 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01029946001 1966603 1991366 GO:0006413 translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01029946001 1966603 1991366 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01029946001 1966603 1991366 GO:0045941 positive regulation of transcription Any cellular process that activates or increases the frequency, rate or extent of transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01029946001 1966603 1991366 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01003387001 9775242 9775609 GSVIVG01019627001 2072755 2075212 GSVIVG01037235001 17025273 17066889 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01037235001 17025273 17066889 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01037235001 17025273 17066889 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01037235001 17025273 17066889 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01037235001 17025273 17066889 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Interacting selectively and non-covalently with chromatin, the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase. IEA GO:0003682 chromatin binding GSVIVG01037235001 17025273 17066889 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with chromatin, the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase. IEA GO:0003682 chromatin binding GSVIVG01037235001 17025273 17066889 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01037235001 17025273 17066889 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01037235001 17025273 17066889 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037235001 17025273 17066889 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034473001 20755696 20776002 GSVIVG01008955001 3831000 3832521 GSVIVG01014409001 3475728 3513246 GSVIVG01031456001 18328137 18331332 GSVIVG01026436001 23632649 23632834 GSVIVG01005202001 19133797 19163806 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01005202001 19133797 19163806 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01005202001 19133797 19163806 GO:0006423 cysteinyl-tRNA aminoacylation The process of coupling cysteine to cysteinyl-tRNA, catalyzed by cysteinyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01005202001 19133797 19163806 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01005202001 19133797 19163806 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01005202001 19133797 19163806 GO:0006423 cysteinyl-tRNA aminoacylation The process of coupling cysteine to cysteinyl-tRNA, catalyzed by cysteinyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01005202001 19133797 19163806 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys). IEA GO:0004817 cysteine-tRNA ligase activity GSVIVG01005202001 19133797 19163806 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys). IEA GO:0004817 cysteine-tRNA ligase activity GSVIVG01005202001 19133797 19163806 GO:0006423 cysteinyl-tRNA aminoacylation The process of coupling cysteine to cysteinyl-tRNA, catalyzed by cysteinyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys). IEA GO:0004817 cysteine-tRNA ligase activity GSVIVG01005202001 19133797 19163806 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01005202001 19133797 19163806 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01005202001 19133797 19163806 GO:0006423 cysteinyl-tRNA aminoacylation The process of coupling cysteine to cysteinyl-tRNA, catalyzed by cysteinyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027477001 16452425 16454564 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01003437001 15041110 15042602 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01012461001 1190025 1192592 GSVIVG01029277001 17683751 17684146 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029277001 17683751 17684146 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01029277001 17683751 17684146 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01002448001 34796058 34798389 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01026178001 13474394 13476958 GSVIVG01018249001 12539948 12547221 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. IEA GO:0004725 protein tyrosine phosphatase activity GSVIVG01018249001 12539948 12547221 GO:0016311 dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. IEA Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. IEA GO:0004725 protein tyrosine phosphatase activity GSVIVG01018249001 12539948 12547221 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA Catalysis of the reaction: protein serine/threonine/tyrosine phosphate + H2O = protein serine/threonine/tyrosine + phosphate. IEA GO:0008138 protein tyrosine/serine/threonine phosphatase activity GSVIVG01018249001 12539948 12547221 GO:0016311 dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. IEA Catalysis of the reaction: protein serine/threonine/tyrosine phosphate + H2O = protein serine/threonine/tyrosine + phosphate. IEA GO:0008138 protein tyrosine/serine/threonine phosphatase activity GSVIVG01018249001 12539948 12547221 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. IEA GO:0016791 phosphatase activity GSVIVG01018249001 12539948 12547221 GO:0016311 dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. IEA Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. IEA GO:0016791 phosphatase activity GSVIVG01001631001 21555625 21565431 GSVIVG01022076001 16404302 16404760 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01022076001 16404302 16404760 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01022076001 16404302 16404760 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01022076001 16404302 16404760 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01022076001 16404302 16404760 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01022076001 16404302 16404760 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01003660001 11863017 11864972 GSVIVG01014162001 968093 977755 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01014162001 968093 977755 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014162001 968093 977755 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014162001 968093 977755 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014162001 968093 977755 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007677001 10578569 10581053 GSVIVG01032814001 540797 547029 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01032814001 540797 547029 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01032814001 540797 547029 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01032814001 540797 547029 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015447001 3771755 3773188 GO:0006596 polyamine biosynthetic process The chemical reactions and pathways resulting in the formation of polyamines, any organic compound containing two or more amino groups. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01004088001 14710270 14711637 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01004088001 14710270 14711637 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01004088001 14710270 14711637 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01004088001 14710270 14711637 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01023919001 2486948 2488738 GO:0019953 sexual reproduction The regular alternation, in the life cycle of haplontic, diplontic and diplohaplontic organisms, of meiosis and fertilization which provides for the production offspring. In diplontic organisms there is a life cycle in which the products of meiosis behave directly as gametes, fusing to form a zygote from which the diploid, or sexually reproductive polyploid, adult organism will develop. In diplohaplontic organisms a haploid phase (gametophyte) exists in the life cycle between meiosis and fertilization (e.g. higher plants, many algae and Fungi); the products of meiosis are spores that develop as haploid individuals from which haploid gametes develop to form a diploid zygote; diplohaplontic organisms show an alternation of haploid and diploid generations. In haplontic organisms meiosis occurs in the zygote, giving rise to four haploid cells (e.g. many algae and protozoa), only the zygote is diploid and this may form a resistant spore, tiding organisms over hard times. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA GSVIVG01004406001 38423739 38425455 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01004406001 38423739 38425455 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01002870001 36916338 36916710 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01007670001 10650118 10651994 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01036692001 23817847 23823394 GO:0006357 regulation of transcription from RNA polymerase II promoter Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. IEA GO:0016592 mediator complex A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. IEA Functions to mediate the interaction of transcriptional activators with the RNA polymerase II-general RNA polymerase II transcription factor complex. IEA GO:0016455 RNA polymerase II transcription mediator activity GSVIVG01017313001 6633693 6644076 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GSVIVG01010809001 22865112 22878894 GSVIVG01003186001 7707455 7711334 GSVIVG01014901001 11442068 11461125 GSVIVG01014777001 9539805 9543833 GO:0006461 protein complex assembly The aggregation, arrangement and bonding together of a set of components to form a protein complex. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031911001 5312671 5316729 GSVIVG01009109001 5121695 5123760 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01009109001 5121695 5123760 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01009109001 5121695 5123760 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01009109001 5121695 5123760 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01014129001 639171 641698 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031898001 5239376 5239970 GSVIVG01018752001 20192413 20209879 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018752001 20192413 20209879 GO:0006013 mannose metabolic process The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018752001 20192413 20209879 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01018752001 20192413 20209879 GO:0006013 mannose metabolic process The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01018752001 20192413 20209879 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. IEA GO:0004559 alpha-mannosidase activity GSVIVG01018752001 20192413 20209879 GO:0006013 mannose metabolic process The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins. IEA Catalysis of the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. IEA GO:0004559 alpha-mannosidase activity GSVIVG01018752001 20192413 20209879 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01018752001 20192413 20209879 GO:0006013 mannose metabolic process The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01018752001 20192413 20209879 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of mannosyl compounds, substances containing a group derived from a cyclic form of mannose or a mannose derivative. IEA GO:0015923 mannosidase activity GSVIVG01018752001 20192413 20209879 GO:0006013 mannose metabolic process The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins. IEA Catalysis of the hydrolysis of mannosyl compounds, substances containing a group derived from a cyclic form of mannose or a mannose derivative. IEA GO:0015923 mannosidase activity GSVIVG01018752001 20192413 20209879 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01018752001 20192413 20209879 GO:0006013 mannose metabolic process The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins. IEA Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01007695001 10303538 10307736 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I The process by which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex. The peptide antigen is typically, but not always, processed from a whole protein. Class I here refers to classical class I molecules. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01026453001 23382368 23384135 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01026453001 23382368 23384135 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01003197001 7783357 7791083 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003197001 7783357 7791083 GO:0009231 riboflavin biosynthetic process The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003197001 7783357 7791083 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: ATP + riboflavin = ADP + FMN. IEA GO:0008531 riboflavin kinase activity GSVIVG01003197001 7783357 7791083 GO:0009231 riboflavin biosynthetic process The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). IEA Catalysis of the reaction: ATP + riboflavin = ADP + FMN. IEA GO:0008531 riboflavin kinase activity GSVIVG01003197001 7783357 7791083 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01003197001 7783357 7791083 GO:0009231 riboflavin biosynthetic process The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01035738001 3819308 3820674 GSVIVG01011072001 1814371 1817725 GO:0006542 glutamine biosynthetic process The chemical reactions and pathways resulting in the formation of glutamine, 2-amino-4-carbamoylbutanoic acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01011072001 1814371 1817725 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01011072001 1814371 1817725 GO:0006542 glutamine biosynthetic process The chemical reactions and pathways resulting in the formation of glutamine, 2-amino-4-carbamoylbutanoic acid. IEA Catalysis of the reaction: ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine. IEA GO:0004356 glutamate-ammonia ligase activity GSVIVG01011072001 1814371 1817725 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA Catalysis of the reaction: ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine. IEA GO:0004356 glutamate-ammonia ligase activity GSVIVG01018692001 11038465 11040455 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01001491001 5138569 5142834 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01001491001 5138569 5142834 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01001491001 5138569 5142834 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01001491001 5138569 5142834 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01001491001 5138569 5142834 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01001491001 5138569 5142834 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01001491001 5138569 5142834 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01001491001 5138569 5142834 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01001491001 5138569 5142834 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001491001 5138569 5142834 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001491001 5138569 5142834 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001491001 5138569 5142834 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001491001 5138569 5142834 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01001491001 5138569 5142834 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01001491001 5138569 5142834 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01001491001 5138569 5142834 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01013057001 9012195 9017414 GSVIVG01032325001 15083604 15088551 GSVIVG01028829001 18304763 18312966 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Catalysis of the synthesis of a short RNA primer on a DNA template, providing a free 3'-OH that can be extended by DNA-directed DNA polymerases. Catalyzed by a DNA-directed RNA polymerase that forms a complex with alpha DNA polymerase. IEA GO:0003896 DNA primase activity GSVIVG01007824001 8674677 8683214 GO:0006364 rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule. IEA GO:0008649 rRNA methyltransferase activity GSVIVG01024335001 1113429 1118355 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01024335001 1113429 1118355 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01021446001 5456679 5461501 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of the terminal 1,2-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2). IEA GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity GSVIVG01021446001 5456679 5461501 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01004025001 1414772 1425866 GSVIVG01022541001 4565503 4569567 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01030363001 5013528 5020217 GSVIVG01033652001 18916867 18918077 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GSVIVG01025312001 2147843 2149110 GSVIVG01006775001 28325279 28326577 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01011183001 7884717 7889320 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01011183001 7884717 7889320 GO:0006878 cellular copper ion homeostasis Any process involved in the maintenance of an internal steady-state of copper ions at the level of a cell. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01011183001 7884717 7889320 GO:0008535 respiratory chain complex IV assembly The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase), the terminal member of the respiratory chain of the mitochondrion and some aerobic bacteria. Cytochrome c oxidases are multi-subunit enzymes containing from 13 subunits in the mammalian mitochondrial form to 3-4 subunits in the bacterial forms. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01011183001 7884717 7889320 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01012718001 939071 947049 GSVIVG01011296001 7843670 7843855 GSVIVG01001397001 24204390 24208912 GSVIVG01023163001 21771433 21774506 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023163001 21771433 21774506 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008350001 3045925 3046839 GSVIVG01018437001 15196653 15199951 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01018437001 15196653 15199951 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01018437001 15196653 15199951 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01018437001 15196653 15199951 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01015266001 2216736 2218978 GO:0019310 inositol catabolic process The chemical reactions and pathways resulting in the breakdown of inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01015266001 2216736 2218978 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01015266001 2216736 2218978 GO:0019310 inositol catabolic process The chemical reactions and pathways resulting in the breakdown of inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: myo-inositol + O2 = D-glucuronate + H2O. IEA GO:0050113 inositol oxygenase activity GSVIVG01015266001 2216736 2218978 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: myo-inositol + O2 = D-glucuronate + H2O. IEA GO:0050113 inositol oxygenase activity GSVIVG01025822001 11501574 11502936 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025822001 11501574 11502936 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019674001 2372080 2385499 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01019674001 2372080 2385499 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01015485001 4101565 4105064 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01015485001 4101565 4105064 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01015485001 4101565 4105064 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01015485001 4101565 4105064 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01029524001 21987931 22006345 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029524001 21987931 22006345 Catalysis of the transfer of a functional group from one position to another within a single molecule. IEA GO:0016866 intramolecular transferase activity GSVIVG01034483001 20619963 20633483 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01034483001 20619963 20633483 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01019880001 4164201 4172140 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019880001 4164201 4172140 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019880001 4164201 4172140 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01019880001 4164201 4172140 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01019880001 4164201 4172140 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01019880001 4164201 4172140 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01014946001 12608004 12612293 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01014946001 12608004 12612293 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01014946001 12608004 12612293 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01014946001 12608004 12612293 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01011865001 3449471 3450097 GSVIVG01031131001 1882118 1883976 GSVIVG01008317001 3316245 3333781 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01008317001 3316245 3333781 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01015590001 5286376 5287923 GSVIVG01006803001 28704203 28704508 GSVIVG01000859001 3142643 3149293 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin. IEA GO:0004221 ubiquitin thiolesterase activity GSVIVG01010987001 2400153 2403519 GSVIVG01034547001 19597267 19609925 GSVIVG01033466001 20451460 20451642 GSVIVG01028033001 3321098 3322169 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA GSVIVG01018969001 18230753 18231994 GSVIVG01009530001 9095607 9096446 GSVIVG01010741001 21986539 22008670 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01010741001 21986539 22008670 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01010741001 21986539 22008670 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01010741001 21986539 22008670 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01027176001 17236930 17240143 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027176001 17236930 17240143 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA Catalysis of the hydrolysis of (1,6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin. Limit dextrin is the highly branched core that remains after exhaustive treatment of glycogen with glycogen phosphorylase. It is formed because these enzymes cannot hydrolyze the 1,6 glycosidic linkages present. IEA GO:0004135 amylo-alpha-1,6-glucosidase activity GSVIVG01016353001 4667227 4712650 GO:0016070 RNA metabolic process The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016353001 4667227 4712650 GO:0016070 RNA metabolic process The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01009288001 7009529 7013066 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01028184001 4472032 4475855 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01028184001 4472032 4475855 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01014113001 501306 518217 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01014113001 501306 518217 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014113001 501306 518217 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014113001 501306 518217 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014113001 501306 518217 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014113001 501306 518217 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009745001 10924790 10934207 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009745001 10924790 10934207 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009745001 10924790 10934207 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01009745001 10924790 10934207 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01009745001 10924790 10934207 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01009745001 10924790 10934207 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01010923001 15616493 15630118 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with transfer RNA. IEA GO:0000049 tRNA binding GSVIVG01010923001 15616493 15630118 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with transfer RNA. IEA GO:0000049 tRNA binding GSVIVG01010923001 15616493 15630118 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with transfer RNA. IEA GO:0000049 tRNA binding GSVIVG01010923001 15616493 15630118 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with transfer RNA. IEA GO:0000049 tRNA binding GSVIVG01010923001 15616493 15630118 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01010923001 15616493 15630118 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01010923001 15616493 15630118 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01010923001 15616493 15630118 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01010923001 15616493 15630118 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01010923001 15616493 15630118 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01010923001 15616493 15630118 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01010923001 15616493 15630118 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01010923001 15616493 15630118 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01010923001 15616493 15630118 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01010923001 15616493 15630118 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01010923001 15616493 15630118 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01010923001 15616493 15630118 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe). IEA GO:0004826 phenylalanine-tRNA ligase activity GSVIVG01010923001 15616493 15630118 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe). IEA GO:0004826 phenylalanine-tRNA ligase activity GSVIVG01010923001 15616493 15630118 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe). IEA GO:0004826 phenylalanine-tRNA ligase activity GSVIVG01010923001 15616493 15630118 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe). IEA GO:0004826 phenylalanine-tRNA ligase activity GSVIVG01010923001 15616493 15630118 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010923001 15616493 15630118 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010923001 15616493 15630118 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010923001 15616493 15630118 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010027001 13581891 13585088 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010027001 13581891 13585088 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010027001 13581891 13585088 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01010027001 13581891 13585088 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01010027001 13581891 13585088 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01010027001 13581891 13585088 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01010027001 13581891 13585088 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01010027001 13581891 13585088 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01010027001 13581891 13585088 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01010027001 13581891 13585088 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01010027001 13581891 13585088 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01010027001 13581891 13585088 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01019295001 1786013 1788751 GO:0015886 heme transport The directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells. IEA GO:0015232 heme transporter activity GSVIVG01019295001 1786013 1788751 GO:0017004 cytochrome complex assembly The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells. IEA GO:0015232 heme transporter activity GSVIVG01003351001 9247912 9253045 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003351001 9247912 9253045 GO:0009072 aromatic amino acid family metabolic process The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003351001 9247912 9253045 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 4-fumarylacetoacetate + H2O = acetoacetate + fumarate. IEA GO:0004334 fumarylacetoacetase activity GSVIVG01003351001 9247912 9253045 GO:0009072 aromatic amino acid family metabolic process The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). IEA Catalysis of the reaction: 4-fumarylacetoacetate + H2O = acetoacetate + fumarate. IEA GO:0004334 fumarylacetoacetase activity GSVIVG01021405001 5014532 5015432 GO:0009765 photosynthesis, light harvesting Absorption and transfer of the energy absorbed from light photons between photosystem reaction centers. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01038386001 11553906 11556174 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01038386001 11553906 11556174 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01038386001 11553906 11556174 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038386001 11553906 11556174 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038386001 11553906 11556174 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01038386001 11553906 11556174 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01019457001 807009 808096 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01019457001 807009 808096 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01003832001 20507825 20508286 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009793001 11294804 11296698 Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01001780001 3040582 3044349 GSVIVG01037063001 8239784 8241124 GSVIVG01010668001 15356606 15361640 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01010668001 15356606 15361640 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01010668001 15356606 15361640 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01010668001 15356606 15361640 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01028107001 3855587 3860101 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01028107001 3855587 3860101 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01008651001 100534 102042 GSVIVG01008416001 2304467 2316230 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GSVIVG01008416001 2304467 2316230 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GSVIVG01016027001 17582028 17582291 GSVIVG01022586001 5502500 5509539 GSVIVG01028860001 18030387 18039463 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01022209001 17482138 17491368 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01022209001 17482138 17491368 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01022209001 17482138 17491368 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01022209001 17482138 17491368 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01022209001 17482138 17491368 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01022209001 17482138 17491368 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011135001 7101154 7102306 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01011135001 7101154 7102306 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01011135001 7101154 7102306 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01006266001 24329948 24335589 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01006266001 24329948 24335589 GO:0030259 lipid glycosylation Covalent attachment of a glycosyl residue to a lipid molecule. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01006266001 24329948 24335589 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01006266001 24329948 24335589 GO:0030259 lipid glycosylation Covalent attachment of a glycosyl residue to a lipid molecule. IEA Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01018099001 6535934 6537509 The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01017999001 5364057 5383593 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GSVIVG01001920001 7213944 7220358 GSVIVG01018403001 9661841 9670181 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01018403001 9661841 9670181 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01018403001 9661841 9670181 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018403001 9661841 9670181 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018403001 9661841 9670181 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01018403001 9661841 9670181 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01018403001 9661841 9670181 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01018403001 9661841 9670181 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01018403001 9661841 9670181 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01018403001 9661841 9670181 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01010632001 15762481 15813405 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01010632001 15762481 15813405 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01010632001 15762481 15813405 GO:0006438 valyl-tRNA aminoacylation The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01010632001 15762481 15813405 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01010632001 15762481 15813405 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01010632001 15762481 15813405 GO:0006438 valyl-tRNA aminoacylation The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01010632001 15762481 15813405 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val). IEA GO:0004832 valine-tRNA ligase activity GSVIVG01010632001 15762481 15813405 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val). IEA GO:0004832 valine-tRNA ligase activity GSVIVG01010632001 15762481 15813405 GO:0006438 valyl-tRNA aminoacylation The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val). IEA GO:0004832 valine-tRNA ligase activity GSVIVG01010632001 15762481 15813405 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010632001 15762481 15813405 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010632001 15762481 15813405 GO:0006438 valyl-tRNA aminoacylation The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000263001 20695409 20704468 GO:0006306 DNA methylation The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01000263001 20695409 20704468 GO:0006306 DNA methylation The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing cytosine = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine. IEA GO:0003886 DNA (cytosine-5-)-methyltransferase activity GSVIVG01000263001 20695409 20704468 GO:0006306 DNA methylation The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01011399001 29339892 29342258 GSVIVG01028133001 4060393 4065151 GSVIVG01019055001 17285216 17297138 GO:0006415 translational termination The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code). IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Involved in catalyzing the release of a nascent polypeptide chain from a ribosome. IEA GO:0003747 translation release factor activity GSVIVG01019055001 17285216 17297138 GO:0006415 translational termination The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code). IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA A translation release factor that is specific for one or more particular termination codons; acts at the ribosomal A-site and require polypeptidyl-tRNA at the P-site. IEA GO:0016149 translation release factor activity, codon specific GSVIVG01017759001 3190856 3194069 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01037920001 6356814 6364398 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA GSVIVG01019802001 3454313 3457988 GO:0006367 transcription initiation from RNA polymerase II promoter A transcription initiation process that results in RNA synthesis by RNA polymerase II. IEA GO:0005673 transcription factor TFIIE complex A transcription factor which in humans consists of a complex of two alpha and two beta chains. Recruits TFIIH to the initiation complex and helps activate both RNA polymerase II and TFIIH. IEA Functions to initiate or regulate RNA polymerase II transcription. IEA GO:0003702 RNA polymerase II transcription factor activity GSVIVG01034320001 14817216 14817932 GSVIVG01034949001 372795 377697 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004185 serine-type carboxypeptidase activity GSVIVG01021476001 5978699 5979856 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01020299001 21721560 21721733 GSVIVG01032998001 24969752 24974529 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Combining with the tridecapeptide neurotensin to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state. IEA GO:0016492 neurotensin receptor activity, G-protein coupled GSVIVG01032998001 24969752 24974529 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with the tridecapeptide neurotensin to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state. IEA GO:0016492 neurotensin receptor activity, G-protein coupled GSVIVG01032998001 24969752 24974529 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Combining with the tridecapeptide neurotensin to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state. IEA GO:0016492 neurotensin receptor activity, G-protein coupled GSVIVG01032998001 24969752 24974529 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with the tridecapeptide neurotensin to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state. IEA GO:0016492 neurotensin receptor activity, G-protein coupled GSVIVG01032998001 24969752 24974529 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01032998001 24969752 24974529 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01032998001 24969752 24974529 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01032998001 24969752 24974529 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01014250001 2014869 2018538 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01014250001 2014869 2018538 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01014250001 2014869 2018538 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01014250001 2014869 2018538 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01014250001 2014869 2018538 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01014250001 2014869 2018538 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014250001 2014869 2018538 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014250001 2014869 2018538 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014250001 2014869 2018538 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014250001 2014869 2018538 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014250001 2014869 2018538 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01014250001 2014869 2018538 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01014250001 2014869 2018538 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01014250001 2014869 2018538 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01014250001 2014869 2018538 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01023315001 19775070 19775893 GSVIVG01017419001 8289927 8292889 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031031001 21159061 21159352 GSVIVG01028469001 8035427 8057344 GO:0016459 myosin complex A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. IEA Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate. IEA GO:0003774 motor activity GSVIVG01028469001 8035427 8057344 GO:0016459 myosin complex A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01028469001 8035427 8057344 GO:0016459 myosin complex A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028469001 8035427 8057344 GO:0016459 myosin complex A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. IEA Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits. IEA GO:0051015 actin filament binding GSVIVG01015442001 3717833 3734949 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01015442001 3717833 3734949 Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01034130001 14974698 14977915 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008336001 3141358 3143615 GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA GSVIVG01010672001 15291156 15292230 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01024809001 6717121 6771122 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01024809001 6717121 6771122 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01024809001 6717121 6771122 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01024809001 6717121 6771122 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024809001 6717121 6771122 Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01024809001 6717121 6771122 Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. IEA GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GSVIVG01024809001 6717121 6771122 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01013912001 6664436 6675058 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. IEA GO:0005179 hormone activity GSVIVG01013912001 6664436 6675058 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. IEA GO:0005179 hormone activity GSVIVG01013912001 6664436 6675058 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01013912001 6664436 6675058 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01009980001 13029894 13036147 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. IEA GO:0016597 amino acid binding GSVIVG01032212001 21471517 21476026 GSVIVG01019913001 4421518 4424601 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019913001 4421518 4424601 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. IEA GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GSVIVG01030117001 10000712 10005486 GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of the reaction: S-adenosyl-L-methionine + [ribulose-1,5-bisphosphate carboxylase]-lysine = S-adenosyl-L-homocysteine + [ribulose-1,5-bisphosphate carboxylase]-N6-methyl-L-lysine. IEA GO:0030785 [ribulose-bisphosphate carboxylase]-lysine N-methyltransferase activity GSVIVG01023509001 10639752 10660269 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023509001 10639752 10660269 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01007629001 11102565 11103601 GSVIVG01008772001 1824485 1825384 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01011419001 29530764 29532865 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01011419001 29530764 29532865 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01017598001 1912866 1914014 GSVIVG01010837001 23240257 23242704 GSVIVG01028267001 5040893 5041881 GSVIVG01030679001 13445730 13447648 GSVIVG01008982001 4035264 4040612 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008982001 4035264 4040612 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). IEA GO:0016769 transferase activity, transferring nitrogenous groups GSVIVG01008982001 4035264 4040612 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + methylthioadenosine. IEA GO:0016847 1-aminocyclopropane-1-carboxylate synthase activity GSVIVG01008982001 4035264 4040612 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01029125001 19334892 19337039 Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate. IEA GO:0008146 sulfotransferase activity GSVIVG01000951001 22216361 22221088 GSVIVG01038186001 24170572 24192389 GSVIVG01021154001 1882350 1941336 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01036631001 19387797 19488309 GSVIVG01001339001 466906 493011 GO:0006561 proline biosynthetic process The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins. IEA Catalysis of the reaction: ATP + L-glutamate = ADP + L-glutamate 5-phosphate. IEA GO:0004349 glutamate 5-kinase activity GSVIVG01001339001 466906 493011 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the reaction: ATP + L-glutamate = ADP + L-glutamate 5-phosphate. IEA GO:0004349 glutamate 5-kinase activity GSVIVG01003789001 12743899 12748095 GSVIVG01017541001 10222796 10226091 GSVIVG01006449001 26074075 26086691 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01022423001 19988853 19995695 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01013124001 7997844 7999451 Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GSVIVG01013124001 7997844 7999451 Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01027078001 18133348 18136210 GSVIVG01031256001 746767 750606 GSVIVG01017440001 8538140 8539556 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: diphosphate + H2O = 2 phosphate. IEA GO:0004427 inorganic diphosphatase activity GSVIVG01017440001 8538140 8539556 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of pyrophosphate, which generates a proton motive force. IEA GO:0009678 hydrogen-translocating pyrophosphatase activity GSVIVG01000264001 20707638 20715321 GO:0006821 chloride transport The directed movement of chloride into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01000264001 20707638 20715321 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01000264001 20707638 20715321 GO:0006821 chloride transport The directed movement of chloride into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a chloride ion by a voltage-gated channel. IEA GO:0005247 voltage-gated chloride channel activity GSVIVG01000264001 20707638 20715321 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a chloride ion by a voltage-gated channel. IEA GO:0005247 voltage-gated chloride channel activity GSVIVG01031426001 18721343 18742290 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01031426001 18721343 18742290 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01031426001 18721343 18742290 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01031426001 18721343 18742290 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01031426001 18721343 18742290 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01031426001 18721343 18742290 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01031426001 18721343 18742290 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA A ligand-dependent receptor found in the nucleus of the cell. IEA GO:0004879 ligand-dependent nuclear receptor activity GSVIVG01031426001 18721343 18742290 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A ligand-dependent receptor found in the nucleus of the cell. IEA GO:0004879 ligand-dependent nuclear receptor activity GSVIVG01031426001 18721343 18742290 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA A ligand-dependent receptor found in the nucleus of the cell. IEA GO:0004879 ligand-dependent nuclear receptor activity GSVIVG01031426001 18721343 18742290 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A ligand-dependent receptor found in the nucleus of the cell. IEA GO:0004879 ligand-dependent nuclear receptor activity GSVIVG01031426001 18721343 18742290 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA A ligand-dependent receptor found in the nucleus of the cell. IEA GO:0004879 ligand-dependent nuclear receptor activity GSVIVG01031426001 18721343 18742290 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A ligand-dependent receptor found in the nucleus of the cell. IEA GO:0004879 ligand-dependent nuclear receptor activity GSVIVG01031426001 18721343 18742290 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01031426001 18721343 18742290 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01031426001 18721343 18742290 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01031426001 18721343 18742290 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01031426001 18721343 18742290 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01031426001 18721343 18742290 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01029971001 2479525 2484883 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the reaction: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine. IEA GO:0003871 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity GSVIVG01029971001 2479525 2484883 GO:0009086 methionine biosynthetic process The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. IEA Catalysis of the reaction: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine. IEA GO:0003871 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity GSVIVG01029971001 2479525 2484883 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01029971001 2479525 2484883 GO:0009086 methionine biosynthetic process The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01011778001 4233087 4235221 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01030123001 10051304 10054407 GSVIVG01023089001 15485791 15486366 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01023089001 15485791 15486366 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01023089001 15485791 15486366 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01023089001 15485791 15486366 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01012232001 376807 378298 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01038695001 20901739 20931865 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01038695001 20901739 20931865 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion. IEA GO:0004806 triglyceride lipase activity GSVIVG01038695001 20901739 20931865 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01010613001 16017972 16022823 GO:0006351 transcription, DNA-dependent The cellular synthesis of RNA on a template of DNA. IEA GO:0030880 RNA polymerase complex Any complex that possesses RNA polymerase activity; generally comprises a catalytic subunit and one or more additional subunits. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01010613001 16017972 16022823 GO:0006351 transcription, DNA-dependent The cellular synthesis of RNA on a template of DNA. IEA GO:0030880 RNA polymerase complex Any complex that possesses RNA polymerase activity; generally comprises a catalytic subunit and one or more additional subunits. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01019779001 3227219 3231782 GSVIVG01024231001 94790 95830 GSVIVG01019259001 2430408 2436655 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01019259001 2430408 2436655 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01019259001 2430408 2436655 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01019259001 2430408 2436655 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01019259001 2430408 2436655 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015876001 18826682 18829241 GSVIVG01034743001 8856857 8858258 GSVIVG01026763001 6533110 6533750 GO:0009790 embryo development The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant. IEA GSVIVG01002243001 33586997 33589290 GSVIVG01003693001 12256713 12260015 GSVIVG01010862001 16756681 16761114 GSVIVG01004024001 1407779 1408951 GSVIVG01037765001 7671332 7674058 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01014450001 3864265 3865832 GSVIVG01000678001 15304173 15306321 GSVIVG01002237001 33568704 33569294 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01002237001 33568704 33569294 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037874001 6851538 6855077 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01037874001 6851538 6855077 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01013521001 2303044 2304064 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013521001 2303044 2304064 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01015295001 2465060 2466640 GSVIVG01021851001 6504652 6526279 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01021851001 6504652 6526279 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01020389001 20226011 20227553 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01007559001 12121984 12149054 GSVIVG01028887001 17812498 17816876 GO:0006364 rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01028887001 17812498 17816876 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01028887001 17812498 17816876 GO:0006364 rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01028887001 17812498 17816876 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01013168001 7241430 7242900 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01015145001 1350241 1354826 GSVIVG01014824001 10189016 10190518 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with transfer RNA. IEA GO:0000049 tRNA binding GSVIVG01014824001 10189016 10190518 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe). IEA GO:0004826 phenylalanine-tRNA ligase activity GSVIVG01014824001 10189016 10190518 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01005873001 22410619 22411339 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01005873001 22410619 22411339 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01005873001 22410619 22411339 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01010548001 16732499 16737019 GSVIVG01023621001 8118148 8119480 GSVIVG01038681001 21043160 21043959 GSVIVG01032490001 27837099 27841803 GSVIVG01037430001 13880707 13883147 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029465001 22551743 22555282 GSVIVG01021067001 14187585 14189829 GSVIVG01008604001 478199 483524 GSVIVG01028482001 8162544 8173677 GSVIVG01036295001 3466474 3467064 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01036295001 3466474 3467064 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01036295001 3466474 3467064 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01036295001 3466474 3467064 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019736001 2848087 2851168 GSVIVG01005211001 19234346 19245268 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01005211001 19234346 19245268 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01005211001 19234346 19245268 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01005211001 19234346 19245268 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01005211001 19234346 19245268 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003210001 7928924 7936045 GSVIVG01007912001 7615881 7632396 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01026078001 24871393 24874057 GSVIVG01034800001 21795416 21796020 GSVIVG01014751001 9199158 9208791 GO:0006282 regulation of DNA repair Any process that modulates the frequency, rate or extent of DNA repair. IEA GSVIVG01023964001 2090779 2108596 Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01023964001 2090779 2108596 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01023964001 2090779 2108596 Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01005075001 18003485 18004136 GSVIVG01021144001 1805314 1808227 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01021144001 1805314 1808227 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01002214001 33428540 33430045 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01002214001 33428540 33430045 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032376001 26801941 26806721 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01032376001 26801941 26806721 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032376001 26801941 26806721 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: ATP + D-ribulose 5-phosphate = ADP + D-ribulose 1,5-bisphosphate. IEA GO:0008974 phosphoribulokinase activity GSVIVG01032376001 26801941 26806721 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01032376001 26801941 26806721 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01005667001 21024004 21038616 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01005667001 21024004 21038616 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01004905001 4685338 4693209 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the reaction: cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA). The enzyme catalyzes the reactivation by light of irradiated DNA. A similar reactivation of irradiated RNA is probably due to a separate enzyme. IEA GO:0003904 deoxyribodipyrimidine photo-lyase activity GSVIVG01004905001 4685338 4693209 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the repair of a photoproduct resulting from ultraviolet irradiation of two adjacent pyrimidine residues in DNA. IEA GO:0003913 DNA photolyase activity GSVIVG01024722001 7458726 7462918 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024722001 7458726 7462918 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01023521001 10441406 10442510 GSVIVG01021965001 5009152 5010295 GSVIVG01005126001 18388412 18395043 GSVIVG01023108001 22478661 22484790 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01022431001 2881169 2882134 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01022503001 4014459 4014735 GSVIVG01030467001 5850400 5877010 GSVIVG01008556001 904847 907405 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01022034001 4039231 4057571 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01022034001 4039231 4057571 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01022034001 4039231 4057571 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01022034001 4039231 4057571 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01032334001 15145356 15145595 GSVIVG01002202001 189743 194745 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01037290001 16403948 16407508 GSVIVG01014229001 1701645 1704786 GSVIVG01013039001 9406776 9411582 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01013039001 9406776 9411582 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01013039001 9406776 9411582 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate. IEA GO:0004470 malic enzyme activity GSVIVG01013039001 9406776 9411582 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate. IEA GO:0004470 malic enzyme activity GSVIVG01013039001 9406776 9411582 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01013039001 9406776 9411582 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01013039001 9406776 9411582 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01013039001 9406776 9411582 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01013039001 9406776 9411582 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01013039001 9406776 9411582 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01014963001 13089548 13090890 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. IEA GO:0004364 glutathione transferase activity GSVIVG01037386001 14584449 14586581 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01037386001 14584449 14586581 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025080001 4679514 4680670 GSVIVG01002234001 33551400 33552509 GSVIVG01008941001 3639936 3646238 GSVIVG01036402001 4680955 4684917 GSVIVG01035426001 1209585 1211712 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035426001 1209585 1211712 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035426001 1209585 1211712 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01035426001 1209585 1211712 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01035426001 1209585 1211712 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01035426001 1209585 1211712 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01014694001 8712744 8718835 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01011632001 5753719 5757294 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01011632001 5753719 5757294 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01028108001 3868327 3869124 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01028108001 3868327 3869124 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01000546001 7237322 7240378 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01018518001 13936417 13955349 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GSVIVG01007346001 31465094 31466152 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01034788001 21653491 21670070 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01006951001 29274595 29277736 GSVIVG01005025001 17283425 17289859 GSVIVG01032531001 28138583 28141320 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion. IEA GO:0004806 triglyceride lipase activity GSVIVG01012500001 44793 58441 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01012500001 44793 58441 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01012500001 44793 58441 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01012500001 44793 58441 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01012500001 44793 58441 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01012500001 44793 58441 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01012500001 44793 58441 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01012500001 44793 58441 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01015358001 2964369 2968609 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage. IEA GO:0016209 antioxidant activity GSVIVG01015358001 2964369 2968609 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01004844001 5602092 5602465 GSVIVG01023519001 10510782 10511787 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01023519001 10510782 10511787 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01032255001 14061497 14090198 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01032255001 14061497 14090198 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01032255001 14061497 14090198 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032255001 14061497 14090198 Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. IEA GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GSVIVG01023339001 19581498 19587766 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023339001 19581498 19587766 GO:0006970 response to osmotic stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023339001 19581498 19587766 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01023339001 19581498 19587766 GO:0006970 response to osmotic stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01023339001 19581498 19587766 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01023339001 19581498 19587766 GO:0006970 response to osmotic stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01023339001 19581498 19587766 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01023339001 19581498 19587766 GO:0006970 response to osmotic stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01023339001 19581498 19587766 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023339001 19581498 19587766 GO:0006970 response to osmotic stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021988001 4686075 4688245 GSVIVG01010521001 21368898 21386389 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01010521001 21368898 21386389 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01010521001 21368898 21386389 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01010521001 21368898 21386389 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01010521001 21368898 21386389 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01010521001 21368898 21386389 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01010521001 21368898 21386389 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01010521001 21368898 21386389 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01010521001 21368898 21386389 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01010617001 15960501 15972075 GSVIVG01013568001 21044652 21052561 GSVIVG01037781001 7814149 7814340 GSVIVG01033571001 19658115 19661156 GSVIVG01030459001 5768511 5773234 GSVIVG01037701001 7076144 7087746 GSVIVG01025313001 2129443 2132947 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01003842001 20609431 20612222 GSVIVG01000881001 3285327 3291317 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01010743001 22039047 22055956 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01010743001 22039047 22055956 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01010743001 22039047 22055956 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01010743001 22039047 22055956 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01010743001 22039047 22055956 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Catalysis of the reaction: 4 ATP + 2 phosphorylase b = 4 ADP + phosphorylase a. IEA GO:0004689 phosphorylase kinase activity GSVIVG01010743001 22039047 22055956 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Catalysis of the reaction: 4 ATP + 2 phosphorylase b = 4 ADP + phosphorylase a. IEA GO:0004689 phosphorylase kinase activity GSVIVG01010743001 22039047 22055956 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01010743001 22039047 22055956 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01010743001 22039047 22055956 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01010743001 22039047 22055956 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01010743001 22039047 22055956 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01010743001 22039047 22055956 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01010743001 22039047 22055956 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. IEA GO:0005516 calmodulin binding GSVIVG01010743001 22039047 22055956 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. IEA GO:0005516 calmodulin binding GSVIVG01010743001 22039047 22055956 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010743001 22039047 22055956 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012696001 747148 773049 GO:0006099 tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. IEA GO:0045252 oxoglutarate dehydrogenase complex A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2). IEA Catalysis of the reaction: succinyl-CoA + dihydrolipoamide = CoA + S-succinyldihydrolipoamide. IEA GO:0004149 dihydrolipoyllysine-residue succinyltransferase activity GSVIVG01012696001 747148 773049 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0045252 oxoglutarate dehydrogenase complex A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2). IEA Catalysis of the reaction: succinyl-CoA + dihydrolipoamide = CoA + S-succinyldihydrolipoamide. IEA GO:0004149 dihydrolipoyllysine-residue succinyltransferase activity GSVIVG01012696001 747148 773049 GO:0006099 tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. IEA GO:0045252 oxoglutarate dehydrogenase complex A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2). IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01012696001 747148 773049 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0045252 oxoglutarate dehydrogenase complex A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2). IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01000156001 15729365 15731934 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01000156001 15729365 15731934 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01000156001 15729365 15731934 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01000156001 15729365 15731934 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01000923001 21937512 21939486 GSVIVG01036686001 23853480 23873991 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01036686001 23853480 23873991 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01036686001 23853480 23873991 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01024388001 1961226 1970407 GSVIVG01029316001 16946925 16948244 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01029316001 16946925 16948244 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01029316001 16946925 16948244 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01029316001 16946925 16948244 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01013165001 7320726 7320902 GSVIVG01024144001 815278 815673 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GSVIVG01014175001 1126917 1130047 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01014175001 1126917 1130047 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01023033001 16585615 16589983 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01023033001 16585615 16589983 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01023033001 16585615 16589983 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008197001 4778584 4784169 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0000015 phosphopyruvate hydratase complex A multimeric enzyme complex, usually a dimer or an octamer, that catalyzes the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate and water. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01008197001 4778584 4784169 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0000015 phosphopyruvate hydratase complex A multimeric enzyme complex, usually a dimer or an octamer, that catalyzes the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate and water. IEA Catalysis of the reaction: 2-phospho-D-glycerate = phosphoenolpyruvate + H2O. IEA GO:0004634 phosphopyruvate hydratase activity GSVIVG01014296001 2392493 2415952 GSVIVG01000191001 16010684 16016053 GSVIVG01035361001 746923 749384 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035361001 746923 749384 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035361001 746923 749384 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01035361001 746923 749384 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01035361001 746923 749384 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01035361001 746923 749384 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01016262001 5805801 5812345 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of the reaction: dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by glycosylamine linkage to protein L-asparagine. IEA GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity GSVIVG01016262001 5805801 5812345 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by glycosylamine linkage to protein L-asparagine. IEA GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity GSVIVG01015188001 1648260 1655486 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01015188001 1648260 1655486 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01015188001 1648260 1655486 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01015188001 1648260 1655486 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01015188001 1648260 1655486 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with single-stranded DNA. IEA GO:0003697 single-stranded DNA binding GSVIVG01015188001 1648260 1655486 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with single-stranded DNA. IEA GO:0003697 single-stranded DNA binding GSVIVG01015188001 1648260 1655486 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015188001 1648260 1655486 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015188001 1648260 1655486 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate in the presence of single- or double-stranded DNA; drives another reaction. IEA GO:0008094 DNA-dependent ATPase activity GSVIVG01015188001 1648260 1655486 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate in the presence of single- or double-stranded DNA; drives another reaction. IEA GO:0008094 DNA-dependent ATPase activity GSVIVG01015188001 1648260 1655486 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01015188001 1648260 1655486 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01012008001 2241578 2247262 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012008001 2241578 2247262 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012008001 2241578 2247262 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012008001 2241578 2247262 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012008001 2241578 2247262 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012008001 2241578 2247262 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012008001 2241578 2247262 GO:0007160 cell-matrix adhesion The binding of a cell to the extracellular matrix via adhesion molecules. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012008001 2241578 2247262 GO:0007160 cell-matrix adhesion The binding of a cell to the extracellular matrix via adhesion molecules. IEA GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012008001 2241578 2247262 GO:0007160 cell-matrix adhesion The binding of a cell to the extracellular matrix via adhesion molecules. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012008001 2241578 2247262 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012008001 2241578 2247262 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012008001 2241578 2247262 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012008001 2241578 2247262 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01012008001 2241578 2247262 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01012008001 2241578 2247262 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01012008001 2241578 2247262 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01012008001 2241578 2247262 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01012008001 2241578 2247262 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01012008001 2241578 2247262 GO:0007160 cell-matrix adhesion The binding of a cell to the extracellular matrix via adhesion molecules. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01012008001 2241578 2247262 GO:0007160 cell-matrix adhesion The binding of a cell to the extracellular matrix via adhesion molecules. IEA GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01012008001 2241578 2247262 GO:0007160 cell-matrix adhesion The binding of a cell to the extracellular matrix via adhesion molecules. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01012008001 2241578 2247262 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01012008001 2241578 2247262 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01012008001 2241578 2247262 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01012008001 2241578 2247262 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01012008001 2241578 2247262 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01012008001 2241578 2247262 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01012008001 2241578 2247262 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01012008001 2241578 2247262 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01012008001 2241578 2247262 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01012008001 2241578 2247262 GO:0007160 cell-matrix adhesion The binding of a cell to the extracellular matrix via adhesion molecules. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01012008001 2241578 2247262 GO:0007160 cell-matrix adhesion The binding of a cell to the extracellular matrix via adhesion molecules. IEA GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01012008001 2241578 2247262 GO:0007160 cell-matrix adhesion The binding of a cell to the extracellular matrix via adhesion molecules. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01012008001 2241578 2247262 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01012008001 2241578 2247262 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01012008001 2241578 2247262 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01012008001 2241578 2247262 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01012008001 2241578 2247262 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01012008001 2241578 2247262 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01012008001 2241578 2247262 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01012008001 2241578 2247262 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01012008001 2241578 2247262 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01012008001 2241578 2247262 GO:0007160 cell-matrix adhesion The binding of a cell to the extracellular matrix via adhesion molecules. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01012008001 2241578 2247262 GO:0007160 cell-matrix adhesion The binding of a cell to the extracellular matrix via adhesion molecules. IEA GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01012008001 2241578 2247262 GO:0007160 cell-matrix adhesion The binding of a cell to the extracellular matrix via adhesion molecules. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01012008001 2241578 2247262 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01012008001 2241578 2247262 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01012008001 2241578 2247262 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01012008001 2241578 2247262 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA A ligand-dependent receptor found in the nucleus of the cell. IEA GO:0004879 ligand-dependent nuclear receptor activity GSVIVG01012008001 2241578 2247262 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA A ligand-dependent receptor found in the nucleus of the cell. IEA GO:0004879 ligand-dependent nuclear receptor activity GSVIVG01012008001 2241578 2247262 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA A ligand-dependent receptor found in the nucleus of the cell. IEA GO:0004879 ligand-dependent nuclear receptor activity GSVIVG01012008001 2241578 2247262 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA A ligand-dependent receptor found in the nucleus of the cell. IEA GO:0004879 ligand-dependent nuclear receptor activity GSVIVG01012008001 2241578 2247262 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA A ligand-dependent receptor found in the nucleus of the cell. IEA GO:0004879 ligand-dependent nuclear receptor activity GSVIVG01012008001 2241578 2247262 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA A ligand-dependent receptor found in the nucleus of the cell. IEA GO:0004879 ligand-dependent nuclear receptor activity GSVIVG01012008001 2241578 2247262 GO:0007160 cell-matrix adhesion The binding of a cell to the extracellular matrix via adhesion molecules. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA A ligand-dependent receptor found in the nucleus of the cell. IEA GO:0004879 ligand-dependent nuclear receptor activity GSVIVG01012008001 2241578 2247262 GO:0007160 cell-matrix adhesion The binding of a cell to the extracellular matrix via adhesion molecules. IEA GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA A ligand-dependent receptor found in the nucleus of the cell. IEA GO:0004879 ligand-dependent nuclear receptor activity GSVIVG01012008001 2241578 2247262 GO:0007160 cell-matrix adhesion The binding of a cell to the extracellular matrix via adhesion molecules. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA A ligand-dependent receptor found in the nucleus of the cell. IEA GO:0004879 ligand-dependent nuclear receptor activity GSVIVG01012008001 2241578 2247262 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA A ligand-dependent receptor found in the nucleus of the cell. IEA GO:0004879 ligand-dependent nuclear receptor activity GSVIVG01012008001 2241578 2247262 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA A ligand-dependent receptor found in the nucleus of the cell. IEA GO:0004879 ligand-dependent nuclear receptor activity GSVIVG01012008001 2241578 2247262 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA A ligand-dependent receptor found in the nucleus of the cell. IEA GO:0004879 ligand-dependent nuclear receptor activity GSVIVG01012008001 2241578 2247262 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The action of a molecule that contributes to the structural integrity of a cell wall. IEA GO:0005199 structural constituent of cell wall GSVIVG01012008001 2241578 2247262 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA The action of a molecule that contributes to the structural integrity of a cell wall. IEA GO:0005199 structural constituent of cell wall GSVIVG01012008001 2241578 2247262 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The action of a molecule that contributes to the structural integrity of a cell wall. IEA GO:0005199 structural constituent of cell wall GSVIVG01012008001 2241578 2247262 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The action of a molecule that contributes to the structural integrity of a cell wall. IEA GO:0005199 structural constituent of cell wall GSVIVG01012008001 2241578 2247262 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA The action of a molecule that contributes to the structural integrity of a cell wall. IEA GO:0005199 structural constituent of cell wall GSVIVG01012008001 2241578 2247262 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The action of a molecule that contributes to the structural integrity of a cell wall. IEA GO:0005199 structural constituent of cell wall GSVIVG01012008001 2241578 2247262 GO:0007160 cell-matrix adhesion The binding of a cell to the extracellular matrix via adhesion molecules. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The action of a molecule that contributes to the structural integrity of a cell wall. IEA GO:0005199 structural constituent of cell wall GSVIVG01012008001 2241578 2247262 GO:0007160 cell-matrix adhesion The binding of a cell to the extracellular matrix via adhesion molecules. IEA GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA The action of a molecule that contributes to the structural integrity of a cell wall. IEA GO:0005199 structural constituent of cell wall GSVIVG01012008001 2241578 2247262 GO:0007160 cell-matrix adhesion The binding of a cell to the extracellular matrix via adhesion molecules. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The action of a molecule that contributes to the structural integrity of a cell wall. IEA GO:0005199 structural constituent of cell wall GSVIVG01012008001 2241578 2247262 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The action of a molecule that contributes to the structural integrity of a cell wall. IEA GO:0005199 structural constituent of cell wall GSVIVG01012008001 2241578 2247262 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA The action of a molecule that contributes to the structural integrity of a cell wall. IEA GO:0005199 structural constituent of cell wall GSVIVG01012008001 2241578 2247262 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The action of a molecule that contributes to the structural integrity of a cell wall. IEA GO:0005199 structural constituent of cell wall GSVIVG01012008001 2241578 2247262 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012008001 2241578 2247262 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012008001 2241578 2247262 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012008001 2241578 2247262 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012008001 2241578 2247262 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012008001 2241578 2247262 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012008001 2241578 2247262 GO:0007160 cell-matrix adhesion The binding of a cell to the extracellular matrix via adhesion molecules. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012008001 2241578 2247262 GO:0007160 cell-matrix adhesion The binding of a cell to the extracellular matrix via adhesion molecules. IEA GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012008001 2241578 2247262 GO:0007160 cell-matrix adhesion The binding of a cell to the extracellular matrix via adhesion molecules. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012008001 2241578 2247262 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012008001 2241578 2247262 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012008001 2241578 2247262 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037429001 13909874 13911725 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000600001 6634488 6643684 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000600001 6634488 6643684 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000600001 6634488 6643684 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000600001 6634488 6643684 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01000600001 6634488 6643684 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01000600001 6634488 6643684 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01000600001 6634488 6643684 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01000600001 6634488 6643684 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01000600001 6634488 6643684 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01000600001 6634488 6643684 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01000600001 6634488 6643684 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01000600001 6634488 6643684 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01006686001 27535180 27536561 GSVIVG01024800001 6841766 6843837 GSVIVG01021566001 7142730 7143799 GSVIVG01011313001 8300495 8303415 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01011313001 8300495 8303415 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01011313001 8300495 8303415 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01011313001 8300495 8303415 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01011313001 8300495 8303415 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01011313001 8300495 8303415 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01020836001 1273034 1362035 GSVIVG01024349001 1291224 1293923 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024349001 1291224 1293923 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024349001 1291224 1293923 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024349001 1291224 1293923 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024349001 1291224 1293923 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01024349001 1291224 1293923 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01029042001 11240549 11267908 GSVIVG01008847001 2777880 2785078 GSVIVG01032477001 27759460 27761705 GSVIVG01021182001 2337444 2342439 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01021182001 2337444 2342439 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01025244001 2766401 2767851 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01024797001 6871166 6873091 GSVIVG01038565001 21810708 21814197 GSVIVG01015428001 3577611 3590979 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032744001 1088122 1091226 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01032744001 1088122 1091226 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01032744001 1088122 1091226 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01032744001 1088122 1091226 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01032744001 1088122 1091226 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01032744001 1088122 1091226 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01011505001 30108004 30118789 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01011505001 30108004 30118789 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01030202001 10519384 10524077 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01030202001 10519384 10524077 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01030202001 10519384 10524077 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01030202001 10519384 10524077 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025924001 27197974 27199926 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025924001 27197974 27199926 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0010181 FMN binding GSVIVG01025924001 27197974 27199926 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031186001 1379045 1391424 GSVIVG01019781001 3248584 3249811 GSVIVG01019780001 3236091 3242957 GSVIVG01003590001 11003404 11007356 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01008902001 3261409 3268404 GSVIVG01010697001 11940417 11940599 GSVIVG01028082001 3665259 3671079 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01028082001 3665259 3671079 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01023755001 10653430 10655088 GSVIVG01021395001 4871921 4876584 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01006504001 42460324 42461994 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA GSVIVG01014330001 2703385 2708789 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01026590001 21277031 21300415 Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01019127001 16467366 16467554 GSVIVG01029853001 443381 451708 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01023804001 3358096 3360699 GSVIVG01002361001 34388208 34390211 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: 2 H2O2 = O2 + 2 H2O. IEA GO:0004096 catalase activity GSVIVG01002361001 34388208 34390211 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2 H2O2 = O2 + 2 H2O. IEA GO:0004096 catalase activity GSVIVG01002361001 34388208 34390211 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01002361001 34388208 34390211 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01002361001 34388208 34390211 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01002361001 34388208 34390211 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01024381001 1781266 1786037 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01024381001 1781266 1786037 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01024381001 1781266 1786037 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01024381001 1781266 1786037 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01024381001 1781266 1786037 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01024381001 1781266 1786037 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01024381001 1781266 1786037 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024381001 1781266 1786037 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01028016001 3210012 3213698 GSVIVG01000176001 15895365 15897957 GSVIVG01007405001 31664550 31667952 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01005070001 17889749 17890221 GSVIVG01017984001 5284997 5285856 GSVIVG01015684001 15558813 15562236 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015684001 15558813 15562236 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015684001 15558813 15562236 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01015684001 15558813 15562236 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01015684001 15558813 15562236 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01015684001 15558813 15562236 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01038107001 23526664 23528119 GSVIVG01030680001 13459968 13460401 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0042025 host cell nucleus A membrane-bounded organelle as it is found in the host cell in which chromosomes are housed and replicated. The host is defined as the larger of the organisms involved in a symbiotic interaction. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01008206001 4682121 4698574 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01011387001 29255269 29264850 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0031461 cullin-RING ubiquitin ligase complex Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity. IEA Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins. IEA GO:0031625 ubiquitin protein ligase binding GSVIVG01033890001 16997182 16999787 GSVIVG01024377001 1757950 1758453 GSVIVG01013632001 1966696 1966854 GSVIVG01032310001 14929179 14965625 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01004977001 17199796 17209278 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) All non-F1 subunits of the mitochondrial hydrogen-transporting ATP synthase, including integral and peripheral mitochondrial inner membrane proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01004977001 17199796 17209278 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01004977001 17199796 17209278 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01004977001 17199796 17209278 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01004977001 17199796 17209278 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01004977001 17199796 17209278 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) All non-F1 subunits of the mitochondrial hydrogen-transporting ATP synthase, including integral and peripheral mitochondrial inner membrane proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01004977001 17199796 17209278 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01004977001 17199796 17209278 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01004977001 17199796 17209278 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01004977001 17199796 17209278 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01004977001 17199796 17209278 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) All non-F1 subunits of the mitochondrial hydrogen-transporting ATP synthase, including integral and peripheral mitochondrial inner membrane proteins. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01004977001 17199796 17209278 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01004977001 17199796 17209278 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01004977001 17199796 17209278 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01004977001 17199796 17209278 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01004977001 17199796 17209278 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) All non-F1 subunits of the mitochondrial hydrogen-transporting ATP synthase, including integral and peripheral mitochondrial inner membrane proteins. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01004977001 17199796 17209278 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01004977001 17199796 17209278 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01004977001 17199796 17209278 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01004977001 17199796 17209278 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01004977001 17199796 17209278 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) All non-F1 subunits of the mitochondrial hydrogen-transporting ATP synthase, including integral and peripheral mitochondrial inner membrane proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01004977001 17199796 17209278 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01004977001 17199796 17209278 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01004977001 17199796 17209278 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01004977001 17199796 17209278 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01004977001 17199796 17209278 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) All non-F1 subunits of the mitochondrial hydrogen-transporting ATP synthase, including integral and peripheral mitochondrial inner membrane proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01004977001 17199796 17209278 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01004977001 17199796 17209278 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01004977001 17199796 17209278 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01004977001 17199796 17209278 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01013978001 8370258 8376417 GSVIVG01005057001 17750045 17752560 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01005057001 17750045 17752560 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01010176001 16801194 16801244 GSVIVG01038517001 10899748 10904643 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038517001 10899748 10904643 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01035909001 5676522 5681319 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum. IEA GO:0003993 acid phosphatase activity GSVIVG01035909001 5676522 5681319 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008237 metallopeptidase activity GSVIVG01035909001 5676522 5681319 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01035909001 5676522 5681319 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01023906001 2545279 2548986 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01023906001 2545279 2548986 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01037716001 7220528 7222925 GSVIVG01019957001 12396939 12403404 GSVIVG01007607001 11321722 11322467 GSVIVG01025240001 2808940 2818566 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025240001 2808940 2818566 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025240001 2808940 2818566 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025240001 2808940 2818566 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025240001 2808940 2818566 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01025240001 2808940 2818566 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01023885001 2676551 2679781 GSVIVG01035139001 1791770 1793585 GSVIVG01031002001 20669987 20677986 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01031002001 20669987 20677986 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01031002001 20669987 20677986 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031002001 20669987 20677986 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01015381001 3143481 3153202 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01015381001 3143481 3153202 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01015381001 3143481 3153202 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015381001 3143481 3153202 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015381001 3143481 3153202 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. IEA GO:0016879 ligase activity, forming carbon-nitrogen bonds GSVIVG01015381001 3143481 3153202 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. IEA GO:0016879 ligase activity, forming carbon-nitrogen bonds GSVIVG01005226001 19507296 19507976 GSVIVG01008378001 2692101 2698566 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01008378001 2692101 2698566 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01008378001 2692101 2698566 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01008378001 2692101 2698566 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01008378001 2692101 2698566 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01008378001 2692101 2698566 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01008378001 2692101 2698566 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01008378001 2692101 2698566 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01008378001 2692101 2698566 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01008378001 2692101 2698566 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out); by a phosphorylative mechanism. IEA GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism GSVIVG01008378001 2692101 2698566 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out); by a phosphorylative mechanism. IEA GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism GSVIVG01008378001 2692101 2698566 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out); by a phosphorylative mechanism. IEA GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism GSVIVG01008378001 2692101 2698566 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out); by a phosphorylative mechanism. IEA GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism GSVIVG01008378001 2692101 2698566 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out); by a phosphorylative mechanism. IEA GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism GSVIVG01008378001 2692101 2698566 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out); by a phosphorylative mechanism. IEA GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism GSVIVG01008378001 2692101 2698566 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out); by a phosphorylative mechanism. IEA GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism GSVIVG01008378001 2692101 2698566 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out); by a phosphorylative mechanism. IEA GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism GSVIVG01008378001 2692101 2698566 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out); by a phosphorylative mechanism. IEA GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism GSVIVG01008378001 2692101 2698566 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01008378001 2692101 2698566 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01008378001 2692101 2698566 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01008378001 2692101 2698566 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01008378001 2692101 2698566 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01008378001 2692101 2698566 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01008378001 2692101 2698566 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01008378001 2692101 2698566 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01008378001 2692101 2698566 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01008378001 2692101 2698566 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01008378001 2692101 2698566 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01008378001 2692101 2698566 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01008378001 2692101 2698566 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01008378001 2692101 2698566 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01008378001 2692101 2698566 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01008378001 2692101 2698566 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01008378001 2692101 2698566 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01008378001 2692101 2698566 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01008378001 2692101 2698566 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01008378001 2692101 2698566 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01008378001 2692101 2698566 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01008378001 2692101 2698566 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01008378001 2692101 2698566 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01008378001 2692101 2698566 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01008378001 2692101 2698566 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01008378001 2692101 2698566 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01008378001 2692101 2698566 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01008378001 2692101 2698566 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01008378001 2692101 2698566 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01008378001 2692101 2698566 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01008378001 2692101 2698566 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01008378001 2692101 2698566 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01008378001 2692101 2698566 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01008378001 2692101 2698566 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01008378001 2692101 2698566 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01008378001 2692101 2698566 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01024038001 1565072 1567815 GSVIVG01030671001 13278625 13279557 GSVIVG01016441001 3884948 3890619 GO:0006955 immune response Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with the tumor necrosis factor receptor. IEA GO:0005164 tumor necrosis factor receptor binding GSVIVG01016441001 3884948 3890619 GO:0006955 immune response Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. IEA GO:0030076 light-harvesting complex A protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center. IEA Interacting selectively and non-covalently with the tumor necrosis factor receptor. IEA GO:0005164 tumor necrosis factor receptor binding GSVIVG01016441001 3884948 3890619 GO:0006955 immune response Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. IEA GO:0030077 plasma membrane light-harvesting complex A plasma membrane protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center. Examples of this complex are found in bacterial species. IEA Interacting selectively and non-covalently with the tumor necrosis factor receptor. IEA GO:0005164 tumor necrosis factor receptor binding GSVIVG01016441001 3884948 3890619 GO:0009772 photosynthetic electron transport in photosystem II Electrons move from the primary electron acceptor (Quinone, Q) through a chain of electron transport molecules in the thylakoid membrane until they reach the ultimate electron acceptor of Photosystem II, which is plastocyanin (PC). The electron is then passed to the P700 chlorophyll a molecules of the reaction centre of photosystem I. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with the tumor necrosis factor receptor. IEA GO:0005164 tumor necrosis factor receptor binding GSVIVG01016441001 3884948 3890619 GO:0009772 photosynthetic electron transport in photosystem II Electrons move from the primary electron acceptor (Quinone, Q) through a chain of electron transport molecules in the thylakoid membrane until they reach the ultimate electron acceptor of Photosystem II, which is plastocyanin (PC). The electron is then passed to the P700 chlorophyll a molecules of the reaction centre of photosystem I. IEA GO:0030076 light-harvesting complex A protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center. IEA Interacting selectively and non-covalently with the tumor necrosis factor receptor. IEA GO:0005164 tumor necrosis factor receptor binding GSVIVG01016441001 3884948 3890619 GO:0009772 photosynthetic electron transport in photosystem II Electrons move from the primary electron acceptor (Quinone, Q) through a chain of electron transport molecules in the thylakoid membrane until they reach the ultimate electron acceptor of Photosystem II, which is plastocyanin (PC). The electron is then passed to the P700 chlorophyll a molecules of the reaction centre of photosystem I. IEA GO:0030077 plasma membrane light-harvesting complex A plasma membrane protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center. Examples of this complex are found in bacterial species. IEA Interacting selectively and non-covalently with the tumor necrosis factor receptor. IEA GO:0005164 tumor necrosis factor receptor binding GSVIVG01016441001 3884948 3890619 GO:0019684 photosynthesis, light reaction The light reactions of photosynthesis, which take place in photosystems II and I. Light energy is harvested and used to power the transfer of electrons among a series of electron donors and acceptors. The final electron acceptor is NADP+, which is reduced to NADPH. NADPH generated from light reactions is used in sugar synthesis in dark reactions. Light reactions also generate a proton motive force across the thylakoid membrane, and the proton gradient is used to synthesize ATP. There are two chemical reactions involved in the light reactions: water oxidation in photosystem II, and NADP reduction in photosystem I. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with the tumor necrosis factor receptor. IEA GO:0005164 tumor necrosis factor receptor binding GSVIVG01016441001 3884948 3890619 GO:0019684 photosynthesis, light reaction The light reactions of photosynthesis, which take place in photosystems II and I. Light energy is harvested and used to power the transfer of electrons among a series of electron donors and acceptors. The final electron acceptor is NADP+, which is reduced to NADPH. NADPH generated from light reactions is used in sugar synthesis in dark reactions. Light reactions also generate a proton motive force across the thylakoid membrane, and the proton gradient is used to synthesize ATP. There are two chemical reactions involved in the light reactions: water oxidation in photosystem II, and NADP reduction in photosystem I. IEA GO:0030076 light-harvesting complex A protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center. IEA Interacting selectively and non-covalently with the tumor necrosis factor receptor. IEA GO:0005164 tumor necrosis factor receptor binding GSVIVG01016441001 3884948 3890619 GO:0019684 photosynthesis, light reaction The light reactions of photosynthesis, which take place in photosystems II and I. Light energy is harvested and used to power the transfer of electrons among a series of electron donors and acceptors. The final electron acceptor is NADP+, which is reduced to NADPH. NADPH generated from light reactions is used in sugar synthesis in dark reactions. Light reactions also generate a proton motive force across the thylakoid membrane, and the proton gradient is used to synthesize ATP. There are two chemical reactions involved in the light reactions: water oxidation in photosystem II, and NADP reduction in photosystem I. IEA GO:0030077 plasma membrane light-harvesting complex A plasma membrane protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center. Examples of this complex are found in bacterial species. IEA Interacting selectively and non-covalently with the tumor necrosis factor receptor. IEA GO:0005164 tumor necrosis factor receptor binding GSVIVG01016441001 3884948 3890619 GO:0006955 immune response Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01016441001 3884948 3890619 GO:0006955 immune response Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. IEA GO:0030076 light-harvesting complex A protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01016441001 3884948 3890619 GO:0006955 immune response Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. IEA GO:0030077 plasma membrane light-harvesting complex A plasma membrane protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center. Examples of this complex are found in bacterial species. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01016441001 3884948 3890619 GO:0009772 photosynthetic electron transport in photosystem II Electrons move from the primary electron acceptor (Quinone, Q) through a chain of electron transport molecules in the thylakoid membrane until they reach the ultimate electron acceptor of Photosystem II, which is plastocyanin (PC). The electron is then passed to the P700 chlorophyll a molecules of the reaction centre of photosystem I. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01016441001 3884948 3890619 GO:0009772 photosynthetic electron transport in photosystem II Electrons move from the primary electron acceptor (Quinone, Q) through a chain of electron transport molecules in the thylakoid membrane until they reach the ultimate electron acceptor of Photosystem II, which is plastocyanin (PC). The electron is then passed to the P700 chlorophyll a molecules of the reaction centre of photosystem I. IEA GO:0030076 light-harvesting complex A protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01016441001 3884948 3890619 GO:0009772 photosynthetic electron transport in photosystem II Electrons move from the primary electron acceptor (Quinone, Q) through a chain of electron transport molecules in the thylakoid membrane until they reach the ultimate electron acceptor of Photosystem II, which is plastocyanin (PC). The electron is then passed to the P700 chlorophyll a molecules of the reaction centre of photosystem I. IEA GO:0030077 plasma membrane light-harvesting complex A plasma membrane protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center. Examples of this complex are found in bacterial species. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01016441001 3884948 3890619 GO:0019684 photosynthesis, light reaction The light reactions of photosynthesis, which take place in photosystems II and I. Light energy is harvested and used to power the transfer of electrons among a series of electron donors and acceptors. The final electron acceptor is NADP+, which is reduced to NADPH. NADPH generated from light reactions is used in sugar synthesis in dark reactions. Light reactions also generate a proton motive force across the thylakoid membrane, and the proton gradient is used to synthesize ATP. There are two chemical reactions involved in the light reactions: water oxidation in photosystem II, and NADP reduction in photosystem I. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01016441001 3884948 3890619 GO:0019684 photosynthesis, light reaction The light reactions of photosynthesis, which take place in photosystems II and I. Light energy is harvested and used to power the transfer of electrons among a series of electron donors and acceptors. The final electron acceptor is NADP+, which is reduced to NADPH. NADPH generated from light reactions is used in sugar synthesis in dark reactions. Light reactions also generate a proton motive force across the thylakoid membrane, and the proton gradient is used to synthesize ATP. There are two chemical reactions involved in the light reactions: water oxidation in photosystem II, and NADP reduction in photosystem I. IEA GO:0030076 light-harvesting complex A protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01016441001 3884948 3890619 GO:0019684 photosynthesis, light reaction The light reactions of photosynthesis, which take place in photosystems II and I. Light energy is harvested and used to power the transfer of electrons among a series of electron donors and acceptors. The final electron acceptor is NADP+, which is reduced to NADPH. NADPH generated from light reactions is used in sugar synthesis in dark reactions. Light reactions also generate a proton motive force across the thylakoid membrane, and the proton gradient is used to synthesize ATP. There are two chemical reactions involved in the light reactions: water oxidation in photosystem II, and NADP reduction in photosystem I. IEA GO:0030077 plasma membrane light-harvesting complex A plasma membrane protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center. Examples of this complex are found in bacterial species. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01036366001 4247413 4277003 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01036366001 4247413 4277003 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01027648001 14674818 14677943 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01030594001 7024921 7027834 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01030594001 7024921 7027834 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01030594001 7024921 7027834 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01030594001 7024921 7027834 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01023102001 22578483 22583591 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01023102001 22578483 22583591 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01030636001 7345126 7346292 GSVIVG01030062001 9342949 9373145 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017378001 7546635 7551078 GSVIVG01000776001 17436 18336 GSVIVG01013665001 2183404 2184271 GSVIVG01008966001 3911381 3917340 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01008966001 3911381 3917340 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds. IEA GO:0015035 protein disulfide oxidoreductase activity GSVIVG01031247001 842432 848411 GO:0016052 carbohydrate catabolic process The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031247001 842432 848411 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031247001 842432 848411 GO:0016052 carbohydrate catabolic process The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01031247001 842432 848411 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01031247001 842432 848411 GO:0016052 carbohydrate catabolic process The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01031247001 842432 848411 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01022419001 19935883 19944182 GSVIVG01013286001 5652307 5660093 GSVIVG01038046001 16876921 16878081 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. IEA GO:0004364 glutathione transferase activity GSVIVG01024056001 1459600 1461579 GO:0001539 ciliary or flagellar motility Cell motility due to movement of cilia or flagella. IEA GO:0009288 bacterial-type flagellum A motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope. IEA Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate. IEA GO:0003774 motor activity GSVIVG01024056001 1459600 1461579 GO:0006935 chemotaxis The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). IEA GO:0009288 bacterial-type flagellum A motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope. IEA Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate. IEA GO:0003774 motor activity GSVIVG01024056001 1459600 1461579 GO:0001539 ciliary or flagellar motility Cell motility due to movement of cilia or flagella. IEA GO:0009288 bacterial-type flagellum A motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024056001 1459600 1461579 GO:0006935 chemotaxis The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). IEA GO:0009288 bacterial-type flagellum A motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025197001 3450493 3451109 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01032791001 752417 757257 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GSVIVG01004784001 16094608 16095311 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01004784001 16094608 16095311 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01004784001 16094608 16095311 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01017484001 9153239 9153677 GSVIVG01007192001 55929 57064 GSVIVG01037791001 7951098 7955705 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004185 serine-type carboxypeptidase activity GSVIVG01006617001 27082540 27090104 GO:0006635 fatty acid beta-oxidation A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Catalysis of the reaction: acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2. IEA GO:0003997 acyl-CoA oxidase activity GSVIVG01006617001 27082540 27090104 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Catalysis of the reaction: acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2. IEA GO:0003997 acyl-CoA oxidase activity GSVIVG01006617001 27082540 27090104 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Catalysis of the reaction: acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2. IEA GO:0003997 acyl-CoA oxidase activity GSVIVG01006617001 27082540 27090104 GO:0006635 fatty acid beta-oxidation A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GSVIVG01006617001 27082540 27090104 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GSVIVG01006617001 27082540 27090104 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GSVIVG01031892001 5204561 5212695 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026611001 21074080 21075193 GSVIVG01032789001 764444 766628 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01024459001 2849198 2849563 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01020777001 2115969 2118370 Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01002329001 34128196 34129651 GSVIVG01014494001 4466858 4469190 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014494001 4466858 4469190 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014494001 4466858 4469190 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014494001 4466858 4469190 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017063001 3887423 3896680 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GSVIVG01020901001 17560597 17561510 GSVIVG01014134001 669185 677944 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014134001 669185 677944 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014134001 669185 677944 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014134001 669185 677944 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014134001 669185 677944 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010864001 16736925 16744161 GO:0048268 clathrin coat assembly The process by which clathrin triskelia are assembled into the ordered structure known as a clathrin cage. IEA GO:0030118 clathrin coat A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes. IEA Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester. IEA GO:0005543 phospholipid binding GSVIVG01010864001 16736925 16744161 GO:0048268 clathrin coat assembly The process by which clathrin triskelia are assembled into the ordered structure known as a clathrin cage. IEA GO:0030118 clathrin coat A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes. IEA Interacting selectively and non-covalently with phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. IEA GO:0005545 phosphatidylinositol binding GSVIVG01010864001 16736925 16744161 GO:0048268 clathrin coat assembly The process by which clathrin triskelia are assembled into the ordered structure known as a clathrin cage. IEA GO:0030118 clathrin coat A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes. IEA Interacting selectively and non-covalently with a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles. IEA GO:0030276 clathrin binding GSVIVG01032546001 28242733 28243644 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005578 proteinaceous extracellular matrix A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01032546001 28242733 28243644 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0031012 extracellular matrix A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as in plants). IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01032546001 28242733 28243644 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005578 proteinaceous extracellular matrix A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01032546001 28242733 28243644 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0031012 extracellular matrix A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as in plants). IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01032546001 28242733 28243644 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005578 proteinaceous extracellular matrix A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008237 metallopeptidase activity GSVIVG01032546001 28242733 28243644 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0031012 extracellular matrix A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as in plants). IEA Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008237 metallopeptidase activity GSVIVG01032546001 28242733 28243644 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005578 proteinaceous extracellular matrix A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008237 metallopeptidase activity GSVIVG01032546001 28242733 28243644 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0031012 extracellular matrix A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as in plants). IEA Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008237 metallopeptidase activity GSVIVG01023606001 7909281 7912138 GSVIVG01003906001 13410821 13414424 GSVIVG01025606001 13654181 13658069 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025606001 13654181 13658069 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025606001 13654181 13658069 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01025606001 13654181 13658069 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01025606001 13654181 13658069 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01025606001 13654181 13658069 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01012629001 204741 208234 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01012629001 204741 208234 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01010978001 2478254 2488582 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028518001 9050362 9054220 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028518001 9050362 9054220 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035733001 3791673 3794237 GSVIVG01019406001 380310 386888 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01019406001 380310 386888 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01019406001 380310 386888 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli. IEA GO:0004707 MAP kinase activity GSVIVG01019406001 380310 386888 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01019406001 380310 386888 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026570001 21594544 21610681 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01026570001 21594544 21610681 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01026570001 21594544 21610681 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01026570001 21594544 21610681 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01026570001 21594544 21610681 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01026570001 21594544 21610681 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01026570001 21594544 21610681 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026570001 21594544 21610681 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026570001 21594544 21610681 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01026570001 21594544 21610681 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01024207001 277284 284427 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01024207001 277284 284427 GO:0006270 DNA-dependent DNA replication initiation The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01024207001 277284 284427 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01024207001 277284 284427 GO:0006270 DNA-dependent DNA replication initiation The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01024207001 277284 284427 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024207001 277284 284427 GO:0006270 DNA-dependent DNA replication initiation The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024207001 277284 284427 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01024207001 277284 284427 GO:0006270 DNA-dependent DNA replication initiation The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01024207001 277284 284427 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01024207001 277284 284427 GO:0006270 DNA-dependent DNA replication initiation The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01019045001 17416868 17417844 GSVIVG01018114001 6654005 6654965 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01018114001 6654005 6654965 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01018114001 6654005 6654965 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01018114001 6654005 6654965 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01018114001 6654005 6654965 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01018114001 6654005 6654965 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01000215001 16141256 16176535 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Interacting selectively and non-covalently with chromatin, the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase. IEA GO:0003682 chromatin binding GSVIVG01000215001 16141256 16176535 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with chromatin, the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase. IEA GO:0003682 chromatin binding GSVIVG01028223001 4745188 4750345 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028060001 3517683 3521453 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GSVIVG01028060001 3517683 3521453 GO:0009607 response to biotic stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism. IEA GSVIVG01021409001 5035822 5045921 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01021409001 5035822 5045921 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01021409001 5035822 5045921 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01021409001 5035822 5045921 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01021409001 5035822 5045921 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01021409001 5035822 5045921 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01021409001 5035822 5045921 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01021409001 5035822 5045921 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01021409001 5035822 5045921 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021409001 5035822 5045921 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034233001 13191232 13199316 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01034233001 13191232 13199316 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01034233001 13191232 13199316 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01034233001 13191232 13199316 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01034233001 13191232 13199316 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01034233001 13191232 13199316 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01034233001 13191232 13199316 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034233001 13191232 13199316 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012157001 972356 975005 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012157001 972356 975005 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034629001 13694348 13699515 GSVIVG01008516001 1200420 1200851 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01011624001 5816681 5821580 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01011624001 5816681 5821580 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01011624001 5816681 5821580 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01035465001 1473563 1476022 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with lysosphingolipid or lysophosphatidic acid to initiate a change in cell activity. IEA GO:0001619 lysosphingolipid and lysophosphatidic acid receptor activity GSVIVG01032935001 24335233 24340925 GO:0009664 plant-type cell wall organization A process that results in the assembly and arrangement of constituent parts of the cellulose and pectin-containing cell wall, or in the disassembly of the cellulose and pectin-containing cell wall. This process is carried out at the cellular level. An example of this process is found in Arabidopsis thaliana. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA GSVIVG01032935001 24335233 24340925 GO:0009664 plant-type cell wall organization A process that results in the assembly and arrangement of constituent parts of the cellulose and pectin-containing cell wall, or in the disassembly of the cellulose and pectin-containing cell wall. This process is carried out at the cellular level. An example of this process is found in Arabidopsis thaliana. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01032935001 24335233 24340925 GO:0019953 sexual reproduction The regular alternation, in the life cycle of haplontic, diplontic and diplohaplontic organisms, of meiosis and fertilization which provides for the production offspring. In diplontic organisms there is a life cycle in which the products of meiosis behave directly as gametes, fusing to form a zygote from which the diploid, or sexually reproductive polyploid, adult organism will develop. In diplohaplontic organisms a haploid phase (gametophyte) exists in the life cycle between meiosis and fertilization (e.g. higher plants, many algae and Fungi); the products of meiosis are spores that develop as haploid individuals from which haploid gametes develop to form a diploid zygote; diplohaplontic organisms show an alternation of haploid and diploid generations. In haplontic organisms meiosis occurs in the zygote, giving rise to four haploid cells (e.g. many algae and protozoa), only the zygote is diploid and this may form a resistant spore, tiding organisms over hard times. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA GSVIVG01032935001 24335233 24340925 GO:0019953 sexual reproduction The regular alternation, in the life cycle of haplontic, diplontic and diplohaplontic organisms, of meiosis and fertilization which provides for the production offspring. In diplontic organisms there is a life cycle in which the products of meiosis behave directly as gametes, fusing to form a zygote from which the diploid, or sexually reproductive polyploid, adult organism will develop. In diplohaplontic organisms a haploid phase (gametophyte) exists in the life cycle between meiosis and fertilization (e.g. higher plants, many algae and Fungi); the products of meiosis are spores that develop as haploid individuals from which haploid gametes develop to form a diploid zygote; diplohaplontic organisms show an alternation of haploid and diploid generations. In haplontic organisms meiosis occurs in the zygote, giving rise to four haploid cells (e.g. many algae and protozoa), only the zygote is diploid and this may form a resistant spore, tiding organisms over hard times. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01021673001 9103457 9108748 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01021673001 9103457 9108748 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01021673001 9103457 9108748 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01021673001 9103457 9108748 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01021673001 9103457 9108748 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019409001 424467 429608 GSVIVG01033961001 16281966 16286466 GSVIVG01028244001 4899927 4903175 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01028244001 4899927 4903175 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01005878001 22456130 22459215 GO:0005992 trehalose biosynthetic process The chemical reactions and pathways resulting in the formation of trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01005878001 22456130 22459215 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026014001 25847096 25853527 GO:0000902 cell morphogenesis The developmental process by which the size or shape of a cell is generated and organized. Morphogenesis pertains to the creation of form. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01026014001 25847096 25853527 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01026014001 25847096 25853527 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01026014001 25847096 25853527 GO:0000902 cell morphogenesis The developmental process by which the size or shape of a cell is generated and organized. Morphogenesis pertains to the creation of form. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026014001 25847096 25853527 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026014001 25847096 25853527 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026014001 25847096 25853527 GO:0000902 cell morphogenesis The developmental process by which the size or shape of a cell is generated and organized. Morphogenesis pertains to the creation of form. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01026014001 25847096 25853527 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01026014001 25847096 25853527 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01026014001 25847096 25853527 GO:0000902 cell morphogenesis The developmental process by which the size or shape of a cell is generated and organized. Morphogenesis pertains to the creation of form. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01026014001 25847096 25853527 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01026014001 25847096 25853527 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01030407001 5320486 5321661 GO:0051260 protein homooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01003850001 12825983 12842496 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01016370001 4403496 4405198 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01009036001 4445589 4452674 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032088001 22837089 22838680 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01003165001 6060015 6064496 GO:0006564 L-serine biosynthetic process The chemical reactions and pathways resulting in the formation of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003165001 6060015 6064496 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003165001 6060015 6064496 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003165001 6060015 6064496 GO:0006564 L-serine biosynthetic process The chemical reactions and pathways resulting in the formation of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. IEA Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+. IEA GO:0004617 phosphoglycerate dehydrogenase activity GSVIVG01003165001 6060015 6064496 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+. IEA GO:0004617 phosphoglycerate dehydrogenase activity GSVIVG01003165001 6060015 6064496 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+. IEA GO:0004617 phosphoglycerate dehydrogenase activity GSVIVG01003165001 6060015 6064496 GO:0006564 L-serine biosynthetic process The chemical reactions and pathways resulting in the formation of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01003165001 6060015 6064496 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01003165001 6060015 6064496 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01003165001 6060015 6064496 GO:0006564 L-serine biosynthetic process The chemical reactions and pathways resulting in the formation of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. IEA Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. IEA GO:0016597 amino acid binding GSVIVG01003165001 6060015 6064496 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. IEA GO:0016597 amino acid binding GSVIVG01003165001 6060015 6064496 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. IEA GO:0016597 amino acid binding GSVIVG01003165001 6060015 6064496 GO:0006564 L-serine biosynthetic process The chemical reactions and pathways resulting in the formation of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01003165001 6060015 6064496 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01003165001 6060015 6064496 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01003165001 6060015 6064496 GO:0006564 L-serine biosynthetic process The chemical reactions and pathways resulting in the formation of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. IEA Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. IEA GO:0048037 cofactor binding GSVIVG01003165001 6060015 6064496 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. IEA GO:0048037 cofactor binding GSVIVG01003165001 6060015 6064496 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. IEA GO:0048037 cofactor binding GSVIVG01038634001 21304768 21311485 GSVIVG01031677001 20086119 20089205 GSVIVG01014625001 5812018 5816845 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01014625001 5812018 5816845 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01014625001 5812018 5816845 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014625001 5812018 5816845 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014625001 5812018 5816845 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01014625001 5812018 5816845 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01014625001 5812018 5816845 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01014625001 5812018 5816845 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01014625001 5812018 5816845 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01014625001 5812018 5816845 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01002095001 32882069 32907062 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01008252001 4069034 4078199 GSVIVG01010349001 19702807 19710688 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01010563001 16587171 16614892 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010563001 16587171 16614892 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010563001 16587171 16614892 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010563001 16587171 16614892 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01010563001 16587171 16614892 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01010563001 16587171 16614892 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01010563001 16587171 16614892 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01010563001 16587171 16614892 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01010563001 16587171 16614892 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01010563001 16587171 16614892 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01010563001 16587171 16614892 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01010563001 16587171 16614892 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01027353001 15965759 15969157 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01027353001 15965759 15969157 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01027353001 15965759 15969157 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01027353001 15965759 15969157 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01027353001 15965759 15969157 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01027353001 15965759 15969157 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035488001 1702685 1708632 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of copper (Cu) ions from one side of a membrane to the other. IEA GO:0005375 copper ion transmembrane transporter activity GSVIVG01032635001 1977391 1984773 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01032635001 1977391 1984773 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01032635001 1977391 1984773 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01032635001 1977391 1984773 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01005060001 17788806 17795484 GSVIVG01000779001 62873 67847 GSVIVG01013732001 8096451 8100142 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024149001 755206 760330 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01020617001 3714210 3718236 GO:0008219 cell death A biological process that results in permanent cessation of all vital functions of a cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01037477001 12983902 12987571 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01037477001 12983902 12987571 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01037477001 12983902 12987571 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037477001 12983902 12987571 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014530001 4865993 4866144 GSVIVG01025771001 12066763 12073853 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004185 serine-type carboxypeptidase activity GSVIVG01019585001 1777416 1779497 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01019585001 1777416 1779497 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01024180001 547345 562468 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01024180001 547345 562468 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01001446001 21080031 21095482 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01001446001 21080031 21095482 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01001446001 21080031 21095482 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01001446001 21080031 21095482 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01001446001 21080031 21095482 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001446001 21080031 21095482 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001446001 21080031 21095482 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01001446001 21080031 21095482 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01001888001 6798192 6799218 GSVIVG01037598001 10154120 10173882 GSVIVG01027038001 18430833 18434976 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01020123001 10114881 10136219 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020123001 10114881 10136219 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020123001 10114881 10136219 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020123001 10114881 10136219 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020123001 10114881 10136219 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020123001 10114881 10136219 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01020123001 10114881 10136219 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01020123001 10114881 10136219 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01020123001 10114881 10136219 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01020123001 10114881 10136219 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01020123001 10114881 10136219 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01020123001 10114881 10136219 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01020123001 10114881 10136219 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01020123001 10114881 10136219 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01020123001 10114881 10136219 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01020123001 10114881 10136219 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01020123001 10114881 10136219 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01020123001 10114881 10136219 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01020123001 10114881 10136219 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01020123001 10114881 10136219 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01020123001 10114881 10136219 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020123001 10114881 10136219 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020123001 10114881 10136219 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020123001 10114881 10136219 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020123001 10114881 10136219 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020123001 10114881 10136219 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020123001 10114881 10136219 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020123001 10114881 10136219 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020123001 10114881 10136219 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020123001 10114881 10136219 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020123001 10114881 10136219 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01020123001 10114881 10136219 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01020123001 10114881 10136219 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01020123001 10114881 10136219 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01020123001 10114881 10136219 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01000526001 13695062 13705253 GSVIVG01000915001 21867975 21876241 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000915001 21867975 21876241 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000915001 21867975 21876241 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000915001 21867975 21876241 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01000915001 21867975 21876241 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01000915001 21867975 21876241 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01000915001 21867975 21876241 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01000915001 21867975 21876241 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01000915001 21867975 21876241 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01000915001 21867975 21876241 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01000915001 21867975 21876241 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01000915001 21867975 21876241 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01000915001 21867975 21876241 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01000915001 21867975 21876241 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01000915001 21867975 21876241 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01009923001 12431386 12431715 GSVIVG01033817001 17507247 17532372 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01009920001 12383518 12402372 GSVIVG01010318001 19401813 19415232 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0000159 protein phosphatase type 2A complex A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit. IEA Modulation of the activity of the enzyme protein phosphatase type 2A. IEA GO:0008601 protein phosphatase type 2A regulator activity GSVIVG01008528001 1081237 1084315 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01008528001 1081237 1084315 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01008528001 1081237 1084315 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015934 large ribosomal subunit The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01037328001 15595576 15620337 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01037328001 15595576 15620337 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end. IEA GO:0004527 exonuclease activity GSVIVG01031619001 19068828 19070888 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031619001 19068828 19070888 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01031619001 19068828 19070888 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01006135001 42016993 42017888 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01006135001 42016993 42017888 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01030472001 5957289 5961705 GSVIVG01013403001 681146 684604 GO:0006006 glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01013403001 681146 684604 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01013403001 681146 684604 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01013403001 681146 684604 GO:0006006 glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. IEA Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+. IEA GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity GSVIVG01013403001 681146 684604 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+. IEA GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity GSVIVG01013403001 681146 684604 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+. IEA GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity GSVIVG01013403001 681146 684604 GO:0006006 glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01013403001 681146 684604 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01013403001 681146 684604 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01013403001 681146 684604 GO:0006006 glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. IEA Catalysis of the reaction: glyceraldehyde 3-phosphate + (phosphate / H2O) + NAD(P)+ = (3-phospho-D-glyceroyl-phosphate / 3-phospho-D-glycerate) + NAD(P)H + H+. IEA GO:0008943 glyceraldehyde-3-phosphate dehydrogenase activity GSVIVG01013403001 681146 684604 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: glyceraldehyde 3-phosphate + (phosphate / H2O) + NAD(P)+ = (3-phospho-D-glyceroyl-phosphate / 3-phospho-D-glycerate) + NAD(P)H + H+. IEA GO:0008943 glyceraldehyde-3-phosphate dehydrogenase activity GSVIVG01013403001 681146 684604 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: glyceraldehyde 3-phosphate + (phosphate / H2O) + NAD(P)+ = (3-phospho-D-glyceroyl-phosphate / 3-phospho-D-glycerate) + NAD(P)H + H+. IEA GO:0008943 glyceraldehyde-3-phosphate dehydrogenase activity GSVIVG01013403001 681146 684604 GO:0006006 glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01013403001 681146 684604 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01013403001 681146 684604 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01013403001 681146 684604 GO:0006006 glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01013403001 681146 684604 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01013403001 681146 684604 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01007836001 8554506 8562707 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01007836001 8554506 8562707 GO:0016043 cellular component organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cellular component. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01007836001 8554506 8562707 GO:0030036 actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01007836001 8554506 8562707 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion. IEA GO:0004806 triglyceride lipase activity GSVIVG01007836001 8554506 8562707 GO:0016043 cellular component organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cellular component. IEA Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion. IEA GO:0004806 triglyceride lipase activity GSVIVG01007836001 8554506 8562707 GO:0030036 actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. IEA Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion. IEA GO:0004806 triglyceride lipase activity GSVIVG01016815001 1624106 1630917 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01016815001 1624106 1630917 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01016815001 1624106 1630917 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01016815001 1624106 1630917 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01016815001 1624106 1630917 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01016815001 1624106 1630917 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01016815001 1624106 1630917 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016815001 1624106 1630917 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016401001 4202089 4216834 GSVIVG01025131001 4136109 4142002 GSVIVG01021549001 6925179 6933603 GSVIVG01008388001 2565691 2576275 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008388001 2565691 2576275 GO:0008299 isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008388001 2565691 2576275 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA. IEA GO:0004421 hydroxymethylglutaryl-CoA synthase activity GSVIVG01008388001 2565691 2576275 GO:0008299 isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. IEA Catalysis of the reaction: acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA. IEA GO:0004421 hydroxymethylglutaryl-CoA synthase activity GSVIVG01011932001 2921237 2927383 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01026054001 25251147 25252690 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01026054001 25251147 25252690 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01026054001 25251147 25252690 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01015012001 424169 426464 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01012005001 2253559 2261347 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01012005001 2253559 2261347 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01012005001 2253559 2261347 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01012005001 2253559 2261347 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01012005001 2253559 2261347 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01012005001 2253559 2261347 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01012005001 2253559 2261347 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012005001 2253559 2261347 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012005001 2253559 2261347 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012005001 2253559 2261347 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012005001 2253559 2261347 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012005001 2253559 2261347 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012005001 2253559 2261347 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the movement of phospholipids from one membrane face to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP. IEA GO:0004012 phospholipid-translocating ATPase activity GSVIVG01012005001 2253559 2261347 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the movement of phospholipids from one membrane face to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP. IEA GO:0004012 phospholipid-translocating ATPase activity GSVIVG01012005001 2253559 2261347 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the movement of phospholipids from one membrane face to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP. IEA GO:0004012 phospholipid-translocating ATPase activity GSVIVG01012005001 2253559 2261347 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the movement of phospholipids from one membrane face to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP. IEA GO:0004012 phospholipid-translocating ATPase activity GSVIVG01012005001 2253559 2261347 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the movement of phospholipids from one membrane face to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP. IEA GO:0004012 phospholipid-translocating ATPase activity GSVIVG01012005001 2253559 2261347 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the movement of phospholipids from one membrane face to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP. IEA GO:0004012 phospholipid-translocating ATPase activity GSVIVG01012005001 2253559 2261347 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012005001 2253559 2261347 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012005001 2253559 2261347 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012005001 2253559 2261347 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012005001 2253559 2261347 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012005001 2253559 2261347 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012005001 2253559 2261347 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01012005001 2253559 2261347 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01012005001 2253559 2261347 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01012005001 2253559 2261347 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01012005001 2253559 2261347 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01012005001 2253559 2261347 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01032701001 1390403 1398935 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of potassium ions (K+) from one side of a membrane to the other. IEA GO:0015079 potassium ion transmembrane transporter activity GSVIVG01013420001 582109 583745 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004197 cysteine-type endopeptidase activity GSVIVG01013420001 582109 583745 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01026713001 5329511 5331050 GSVIVG01007580001 11694437 11701341 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0009360 DNA polymerase III complex A DNA polymerase complex that contains two complexes of the catalytic alpha, beta, delta and epsilon polymerase/exonuclease subunits, plus the DnaX complex, a heptamer that includes the tau and gamma products of the dnaX gene and confers structural asymmetry that allows the polymerase to replicate both leading and lagging strands. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01007580001 11694437 11701341 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0009360 DNA polymerase III complex A DNA polymerase complex that contains two complexes of the catalytic alpha, beta, delta and epsilon polymerase/exonuclease subunits, plus the DnaX complex, a heptamer that includes the tau and gamma products of the dnaX gene and confers structural asymmetry that allows the polymerase to replicate both leading and lagging strands. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01007580001 11694437 11701341 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0009360 DNA polymerase III complex A DNA polymerase complex that contains two complexes of the catalytic alpha, beta, delta and epsilon polymerase/exonuclease subunits, plus the DnaX complex, a heptamer that includes the tau and gamma products of the dnaX gene and confers structural asymmetry that allows the polymerase to replicate both leading and lagging strands. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01007580001 11694437 11701341 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0009360 DNA polymerase III complex A DNA polymerase complex that contains two complexes of the catalytic alpha, beta, delta and epsilon polymerase/exonuclease subunits, plus the DnaX complex, a heptamer that includes the tau and gamma products of the dnaX gene and confers structural asymmetry that allows the polymerase to replicate both leading and lagging strands. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01007580001 11694437 11701341 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0009360 DNA polymerase III complex A DNA polymerase complex that contains two complexes of the catalytic alpha, beta, delta and epsilon polymerase/exonuclease subunits, plus the DnaX complex, a heptamer that includes the tau and gamma products of the dnaX gene and confers structural asymmetry that allows the polymerase to replicate both leading and lagging strands. IEA Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and primer. IEA GO:0003887 DNA-directed DNA polymerase activity GSVIVG01007580001 11694437 11701341 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0009360 DNA polymerase III complex A DNA polymerase complex that contains two complexes of the catalytic alpha, beta, delta and epsilon polymerase/exonuclease subunits, plus the DnaX complex, a heptamer that includes the tau and gamma products of the dnaX gene and confers structural asymmetry that allows the polymerase to replicate both leading and lagging strands. IEA Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and primer. IEA GO:0003887 DNA-directed DNA polymerase activity GSVIVG01007580001 11694437 11701341 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0009360 DNA polymerase III complex A DNA polymerase complex that contains two complexes of the catalytic alpha, beta, delta and epsilon polymerase/exonuclease subunits, plus the DnaX complex, a heptamer that includes the tau and gamma products of the dnaX gene and confers structural asymmetry that allows the polymerase to replicate both leading and lagging strands. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01007580001 11694437 11701341 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0009360 DNA polymerase III complex A DNA polymerase complex that contains two complexes of the catalytic alpha, beta, delta and epsilon polymerase/exonuclease subunits, plus the DnaX complex, a heptamer that includes the tau and gamma products of the dnaX gene and confers structural asymmetry that allows the polymerase to replicate both leading and lagging strands. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01007580001 11694437 11701341 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0009360 DNA polymerase III complex A DNA polymerase complex that contains two complexes of the catalytic alpha, beta, delta and epsilon polymerase/exonuclease subunits, plus the DnaX complex, a heptamer that includes the tau and gamma products of the dnaX gene and confers structural asymmetry that allows the polymerase to replicate both leading and lagging strands. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01007580001 11694437 11701341 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0009360 DNA polymerase III complex A DNA polymerase complex that contains two complexes of the catalytic alpha, beta, delta and epsilon polymerase/exonuclease subunits, plus the DnaX complex, a heptamer that includes the tau and gamma products of the dnaX gene and confers structural asymmetry that allows the polymerase to replicate both leading and lagging strands. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01007580001 11694437 11701341 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0009360 DNA polymerase III complex A DNA polymerase complex that contains two complexes of the catalytic alpha, beta, delta and epsilon polymerase/exonuclease subunits, plus the DnaX complex, a heptamer that includes the tau and gamma products of the dnaX gene and confers structural asymmetry that allows the polymerase to replicate both leading and lagging strands. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007580001 11694437 11701341 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0009360 DNA polymerase III complex A DNA polymerase complex that contains two complexes of the catalytic alpha, beta, delta and epsilon polymerase/exonuclease subunits, plus the DnaX complex, a heptamer that includes the tau and gamma products of the dnaX gene and confers structural asymmetry that allows the polymerase to replicate both leading and lagging strands. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007580001 11694437 11701341 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0009360 DNA polymerase III complex A DNA polymerase complex that contains two complexes of the catalytic alpha, beta, delta and epsilon polymerase/exonuclease subunits, plus the DnaX complex, a heptamer that includes the tau and gamma products of the dnaX gene and confers structural asymmetry that allows the polymerase to replicate both leading and lagging strands. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01007580001 11694437 11701341 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0009360 DNA polymerase III complex A DNA polymerase complex that contains two complexes of the catalytic alpha, beta, delta and epsilon polymerase/exonuclease subunits, plus the DnaX complex, a heptamer that includes the tau and gamma products of the dnaX gene and confers structural asymmetry that allows the polymerase to replicate both leading and lagging strands. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01030067001 9432243 9433164 GSVIVG01009015001 4300743 4300844 GSVIVG01020269001 22065409 22070479 GO:0006525 arginine metabolic process The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01020269001 22065409 22070479 GO:0006525 arginine metabolic process The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid. IEA Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. IEA GO:0008483 transaminase activity GSVIVG01020269001 22065409 22070479 GO:0006525 arginine metabolic process The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01011631001 5757321 5757961 GSVIVG01036157001 19994385 19996136 GSVIVG01019937001 4609185 4617105 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01028067001 3572645 3575149 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01003999001 14159572 14168835 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003999001 14159572 14168835 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01003999001 14159572 14168835 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01035962001 6534776 6537262 GO:0009073 aromatic amino acid family biosynthetic process The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). IEA Catalysis of the reaction: chorismate = prephenate. IEA GO:0004106 chorismate mutase activity GSVIVG01035962001 6534776 6537262 GO:0046417 chorismate metabolic process The chemical reactions and pathways involving chorismate, the anion of (3R-trans)-3-((1-carboxyethenyl)oxy)-4-hydroxy-1,5-cyclohexadiene-1-carboxylic acid. IEA Catalysis of the reaction: chorismate = prephenate. IEA GO:0004106 chorismate mutase activity GSVIVG01004725001 15550574 15553082 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01004725001 15550574 15553082 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01020216001 8955333 8956374 GSVIVG01021015001 15291833 15293125 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01014635001 8035822 8037817 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01014635001 8035822 8037817 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01014635001 8035822 8037817 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01014635001 8035822 8037817 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01010359001 19772666 19777638 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01010359001 19772666 19777638 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: linoleate + O2 = (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate. IEA GO:0016165 lipoxygenase activity GSVIVG01010359001 19772666 19777638 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor. IEA GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen GSVIVG01010359001 19772666 19777638 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01031782001 4318215 4325277 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004185 serine-type carboxypeptidase activity GSVIVG01014776001 9531038 9539130 GSVIVG01001801001 3371948 3372930 GSVIVG01031588001 18540775 18541924 GSVIVG01017085001 4065357 4065756 GSVIVG01024728001 7418557 7422171 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01024728001 7418557 7422171 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01021600001 7866454 7866873 GSVIVG01028071001 3589258 3593235 GSVIVG01038134001 23719526 23724684 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GSVIVG01038134001 23719526 23724684 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GSVIVG01009806001 11397780 11406230 GO:0006367 transcription initiation from RNA polymerase II promoter A transcription initiation process that results in RNA synthesis by RNA polymerase II. IEA GO:0005674 transcription factor TFIIF complex A general transcription initiation factor which in humans consists of a heterodimer of an alpha and a beta subunit. Helps recruit RNA polymerase II to the initiation complex and promotes translation elongation. IEA Functions to initiate or regulate RNA polymerase II transcription. IEA GO:0003702 RNA polymerase II transcription factor activity GSVIVG01009806001 11397780 11406230 GO:0006367 transcription initiation from RNA polymerase II promoter A transcription initiation process that results in RNA synthesis by RNA polymerase II. IEA GO:0005674 transcription factor TFIIF complex A general transcription initiation factor which in humans consists of a heterodimer of an alpha and a beta subunit. Helps recruit RNA polymerase II to the initiation complex and promotes translation elongation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009806001 11397780 11406230 GO:0006367 transcription initiation from RNA polymerase II promoter A transcription initiation process that results in RNA synthesis by RNA polymerase II. IEA GO:0005674 transcription factor TFIIF complex A general transcription initiation factor which in humans consists of a heterodimer of an alpha and a beta subunit. Helps recruit RNA polymerase II to the initiation complex and promotes translation elongation. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038383001 11517172 11523672 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Catalysis of the endonucleolytic cleavage of RNA, removing 5' extra nucleotides from tRNA precursor. IEA GO:0004526 ribonuclease P activity GSVIVG01008800001 2222531 2227556 GSVIVG01033990001 16055034 16055231 GSVIVG01008088001 5872154 5873542 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021439001 5365870 5376669 GSVIVG01023860001 2921752 2923596 GSVIVG01000038001 2975561 2976800 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000038001 2975561 2976800 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000038001 2975561 2976800 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000038001 2975561 2976800 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01000038001 2975561 2976800 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01000038001 2975561 2976800 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01000038001 2975561 2976800 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01000038001 2975561 2976800 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01000038001 2975561 2976800 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01000038001 2975561 2976800 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01000038001 2975561 2976800 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01000038001 2975561 2976800 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024386001 1915524 1934440 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA Catalysis of the reaction: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA. IEA GO:0004045 aminoacyl-tRNA hydrolase activity GSVIVG01008608001 443116 443631 GSVIVG01017427001 8402841 8403293 GSVIVG01003804001 285396 290470 GSVIVG01022113001 16682441 16697668 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01022113001 16682441 16697668 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01022113001 16682441 16697668 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked either to ribose or deoxyribose. IEA GO:0001882 nucleoside binding GSVIVG01022113001 16682441 16697668 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked either to ribose or deoxyribose. IEA GO:0001882 nucleoside binding GSVIVG01022113001 16682441 16697668 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01022113001 16682441 16697668 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01022113001 16682441 16697668 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01022113001 16682441 16697668 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01022113001 16682441 16697668 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and primer. IEA GO:0003887 DNA-directed DNA polymerase activity GSVIVG01022113001 16682441 16697668 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and primer. IEA GO:0003887 DNA-directed DNA polymerase activity GSVIVG01021516001 6471509 6472788 GSVIVG01024627001 8264468 8267029 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01024627001 8264468 8267029 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01024627001 8264468 8267029 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01014371001 3110460 3131353 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012131001 1169466 1177451 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01012131001 1169466 1177451 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01012131001 1169466 1177451 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01012131001 1169466 1177451 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01012131001 1169466 1177451 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01012131001 1169466 1177451 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01012131001 1169466 1177451 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01012131001 1169466 1177451 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01012131001 1169466 1177451 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01012131001 1169466 1177451 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01012131001 1169466 1177451 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01012131001 1169466 1177451 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01012131001 1169466 1177451 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01012131001 1169466 1177451 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01012131001 1169466 1177451 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01012131001 1169466 1177451 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01012131001 1169466 1177451 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01012131001 1169466 1177451 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01012131001 1169466 1177451 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012131001 1169466 1177451 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012131001 1169466 1177451 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012131001 1169466 1177451 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012131001 1169466 1177451 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012131001 1169466 1177451 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012131001 1169466 1177451 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012131001 1169466 1177451 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012131001 1169466 1177451 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012131001 1169466 1177451 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012131001 1169466 1177451 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012131001 1169466 1177451 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012131001 1169466 1177451 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012131001 1169466 1177451 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012131001 1169466 1177451 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012131001 1169466 1177451 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012131001 1169466 1177451 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012131001 1169466 1177451 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012131001 1169466 1177451 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012131001 1169466 1177451 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012131001 1169466 1177451 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012131001 1169466 1177451 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012131001 1169466 1177451 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012131001 1169466 1177451 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012131001 1169466 1177451 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012131001 1169466 1177451 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012131001 1169466 1177451 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012131001 1169466 1177451 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012131001 1169466 1177451 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012131001 1169466 1177451 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012131001 1169466 1177451 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012131001 1169466 1177451 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012131001 1169466 1177451 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012131001 1169466 1177451 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012131001 1169466 1177451 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012131001 1169466 1177451 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012131001 1169466 1177451 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. IEA GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity GSVIVG01012131001 1169466 1177451 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. IEA GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity GSVIVG01012131001 1169466 1177451 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. IEA GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity GSVIVG01012131001 1169466 1177451 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. IEA GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity GSVIVG01012131001 1169466 1177451 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. IEA GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity GSVIVG01012131001 1169466 1177451 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. IEA GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity GSVIVG01012131001 1169466 1177451 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. IEA GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity GSVIVG01012131001 1169466 1177451 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. IEA GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity GSVIVG01012131001 1169466 1177451 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. IEA GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity GSVIVG01012131001 1169466 1177451 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. IEA GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity GSVIVG01012131001 1169466 1177451 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. IEA GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity GSVIVG01012131001 1169466 1177451 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. IEA GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity GSVIVG01012131001 1169466 1177451 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. IEA GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity GSVIVG01012131001 1169466 1177451 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. IEA GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity GSVIVG01012131001 1169466 1177451 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. IEA GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity GSVIVG01012131001 1169466 1177451 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. IEA GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity GSVIVG01012131001 1169466 1177451 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. IEA GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity GSVIVG01012131001 1169466 1177451 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. IEA GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity GSVIVG01012131001 1169466 1177451 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01012131001 1169466 1177451 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01012131001 1169466 1177451 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01012131001 1169466 1177451 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01012131001 1169466 1177451 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01012131001 1169466 1177451 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01012131001 1169466 1177451 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01012131001 1169466 1177451 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01012131001 1169466 1177451 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01012131001 1169466 1177451 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01012131001 1169466 1177451 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01012131001 1169466 1177451 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01012131001 1169466 1177451 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01012131001 1169466 1177451 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01012131001 1169466 1177451 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01012131001 1169466 1177451 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01012131001 1169466 1177451 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01012131001 1169466 1177451 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01012131001 1169466 1177451 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01012131001 1169466 1177451 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01012131001 1169466 1177451 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01012131001 1169466 1177451 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01012131001 1169466 1177451 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01012131001 1169466 1177451 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01012131001 1169466 1177451 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01012131001 1169466 1177451 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01012131001 1169466 1177451 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01012131001 1169466 1177451 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01012131001 1169466 1177451 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01012131001 1169466 1177451 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01012131001 1169466 1177451 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01012131001 1169466 1177451 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01012131001 1169466 1177451 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01012131001 1169466 1177451 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01012131001 1169466 1177451 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01012131001 1169466 1177451 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01012131001 1169466 1177451 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012131001 1169466 1177451 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012131001 1169466 1177451 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012131001 1169466 1177451 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012131001 1169466 1177451 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012131001 1169466 1177451 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012131001 1169466 1177451 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012131001 1169466 1177451 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012131001 1169466 1177451 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012131001 1169466 1177451 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012131001 1169466 1177451 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012131001 1169466 1177451 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012131001 1169466 1177451 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012131001 1169466 1177451 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012131001 1169466 1177451 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012131001 1169466 1177451 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012131001 1169466 1177451 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012131001 1169466 1177451 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012131001 1169466 1177451 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01012131001 1169466 1177451 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01012131001 1169466 1177451 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01012131001 1169466 1177451 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01012131001 1169466 1177451 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01012131001 1169466 1177451 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01012131001 1169466 1177451 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01012131001 1169466 1177451 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01012131001 1169466 1177451 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01012131001 1169466 1177451 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01012131001 1169466 1177451 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01012131001 1169466 1177451 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01012131001 1169466 1177451 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01012131001 1169466 1177451 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01012131001 1169466 1177451 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01012131001 1169466 1177451 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01012131001 1169466 1177451 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01012131001 1169466 1177451 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01012131001 1169466 1177451 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01012131001 1169466 1177451 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01012131001 1169466 1177451 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01012131001 1169466 1177451 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01012131001 1169466 1177451 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01012131001 1169466 1177451 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01012131001 1169466 1177451 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01012131001 1169466 1177451 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01012131001 1169466 1177451 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01012131001 1169466 1177451 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01012131001 1169466 1177451 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01012131001 1169466 1177451 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01012131001 1169466 1177451 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01012131001 1169466 1177451 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01012131001 1169466 1177451 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01012131001 1169466 1177451 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01012131001 1169466 1177451 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01012131001 1169466 1177451 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01012131001 1169466 1177451 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01012131001 1169466 1177451 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01012131001 1169466 1177451 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01012131001 1169466 1177451 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01012131001 1169466 1177451 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01012131001 1169466 1177451 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01012131001 1169466 1177451 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01012131001 1169466 1177451 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01012131001 1169466 1177451 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01012131001 1169466 1177451 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01012131001 1169466 1177451 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01012131001 1169466 1177451 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01012131001 1169466 1177451 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01012131001 1169466 1177451 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01012131001 1169466 1177451 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01012131001 1169466 1177451 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01012131001 1169466 1177451 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01012131001 1169466 1177451 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01012131001 1169466 1177451 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01012131001 1169466 1177451 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01012131001 1169466 1177451 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01012131001 1169466 1177451 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01012131001 1169466 1177451 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01012131001 1169466 1177451 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01012131001 1169466 1177451 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01012131001 1169466 1177451 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01012131001 1169466 1177451 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01012131001 1169466 1177451 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01012131001 1169466 1177451 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01012131001 1169466 1177451 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01012131001 1169466 1177451 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01012131001 1169466 1177451 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01012131001 1169466 1177451 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01012131001 1169466 1177451 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01012131001 1169466 1177451 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01012131001 1169466 1177451 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01012131001 1169466 1177451 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01012131001 1169466 1177451 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01012131001 1169466 1177451 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01012131001 1169466 1177451 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01012131001 1169466 1177451 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01012131001 1169466 1177451 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01012131001 1169466 1177451 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01012131001 1169466 1177451 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01012131001 1169466 1177451 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01012131001 1169466 1177451 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01012131001 1169466 1177451 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01012131001 1169466 1177451 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01012131001 1169466 1177451 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01012131001 1169466 1177451 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01012131001 1169466 1177451 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01012131001 1169466 1177451 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01012131001 1169466 1177451 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01012131001 1169466 1177451 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01012131001 1169466 1177451 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01012131001 1169466 1177451 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01012131001 1169466 1177451 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01012131001 1169466 1177451 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01012131001 1169466 1177451 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01012131001 1169466 1177451 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01012131001 1169466 1177451 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01012131001 1169466 1177451 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01012131001 1169466 1177451 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01012131001 1169466 1177451 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01012131001 1169466 1177451 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01012131001 1169466 1177451 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01012131001 1169466 1177451 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01012131001 1169466 1177451 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01012131001 1169466 1177451 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01012131001 1169466 1177451 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01012131001 1169466 1177451 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01012131001 1169466 1177451 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01034915001 86824 89944 GSVIVG01007588001 11600216 11606424 GSVIVG01009603001 9802985 9804462 GSVIVG01037767001 7685299 7696805 GSVIVG01030864001 17887103 17887852 GSVIVG01033797001 17751762 17755236 GSVIVG01031978001 5870397 5873133 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031978001 5870397 5873133 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031978001 5870397 5873133 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01031978001 5870397 5873133 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01004799001 2440 5536 GSVIVG01023865001 2896411 2902779 GSVIVG01031614001 18955956 18957477 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01016935001 2709772 2712156 GSVIVG01005410001 40081018 40081956 GO:0009308 amine metabolic process The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01005410001 40081018 40081956 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01005410001 40081018 40081956 GO:0009308 amine metabolic process The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. IEA Catalysis of the reaction: R-CH2-NH2 + H2O + O2 = R-CHO + NH3 + H2O2. IEA GO:0008131 amine oxidase activity GSVIVG01005410001 40081018 40081956 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: R-CH2-NH2 + H2O + O2 = R-CHO + NH3 + H2O2. IEA GO:0008131 amine oxidase activity GSVIVG01005410001 40081018 40081956 GO:0009308 amine metabolic process The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. IEA Interacting selectively and non-covalently with a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds. IEA GO:0048038 quinone binding GSVIVG01005410001 40081018 40081956 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds. IEA GO:0048038 quinone binding GSVIVG01003592001 11011399 11051097 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01003592001 11011399 11051097 Catalysis of the reaction: ATP + shikimate = ADP + shikimate 3-phosphate. IEA GO:0004765 shikimate kinase activity GSVIVG01003592001 11011399 11051097 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003592001 11011399 11051097 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01030649001 7477102 7493792 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01007446001 31987055 31995727 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01007446001 31987055 31995727 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01007446001 31987055 31995727 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01007446001 31987055 31995727 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003184001 7694075 7694830 GSVIVG01010089001 15215062 15216231 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01024658001 7980312 7981055 GSVIVG01022947001 17720895 17725714 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01022947001 17720895 17725714 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01022947001 17720895 17725714 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022947001 17720895 17725714 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017067001 3925535 3932359 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01017067001 3925535 3932359 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01017067001 3925535 3932359 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017067001 3925535 3932359 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017067001 3925535 3932359 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01017067001 3925535 3932359 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01017067001 3925535 3932359 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01017067001 3925535 3932359 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01017067001 3925535 3932359 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. IEA GO:0048037 cofactor binding GSVIVG01017067001 3925535 3932359 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. IEA GO:0048037 cofactor binding GSVIVG01017067001 3925535 3932359 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01017067001 3925535 3932359 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01008705001 1330120 1337723 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008705001 1330120 1337723 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01013108001 8212542 8220356 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA Catalysis of the reaction: ATP + shikimate = ADP + shikimate 3-phosphate. IEA GO:0004765 shikimate kinase activity GSVIVG01013108001 8212542 8220356 GO:0008037 cell recognition The process by which a cell in a multicellular organism interprets its surroundings. IEA Catalysis of the reaction: ATP + shikimate = ADP + shikimate 3-phosphate. IEA GO:0004765 shikimate kinase activity GSVIVG01013108001 8212542 8220356 GO:0019058 viral infectious cycle A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome. IEA Catalysis of the reaction: ATP + shikimate = ADP + shikimate 3-phosphate. IEA GO:0004765 shikimate kinase activity GSVIVG01013108001 8212542 8220356 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013108001 8212542 8220356 GO:0008037 cell recognition The process by which a cell in a multicellular organism interprets its surroundings. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013108001 8212542 8220356 GO:0019058 viral infectious cycle A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029638001 20315607 20318635 GSVIVG01027999001 3101203 3102731 GSVIVG01006370001 25318641 25324607 GSVIVG01026130001 12699394 12700589 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: 3-alpha(S)-strictosidine = tryptamine + secologanin. IEA GO:0016844 strictosidine synthase activity GSVIVG01024899001 6168813 6171922 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024899001 6168813 6171922 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024899001 6168813 6171922 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024899001 6168813 6171922 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01024899001 6168813 6171922 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01024899001 6168813 6171922 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01024899001 6168813 6171922 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024899001 6168813 6171922 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024899001 6168813 6171922 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024899001 6168813 6171922 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01024899001 6168813 6171922 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01024899001 6168813 6171922 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01024899001 6168813 6171922 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024899001 6168813 6171922 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024899001 6168813 6171922 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01011750001 4559807 4564709 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004185 serine-type carboxypeptidase activity GSVIVG01038461001 12803704 12804598 GSVIVG01027478001 16447701 16451349 GSVIVG01004030001 14339744 14340413 GSVIVG01024535001 9082398 9084949 GSVIVG01020849001 1106406 1107172 GSVIVG01031754001 4067224 4070468 GSVIVG01021726001 10104903 10113010 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021726001 10104903 10113010 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021726001 10104903 10113010 Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01033673001 18771817 18775120 GO:0006730 one-carbon metabolic process The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. IEA Catalysis of the reaction: H2CO3 = CO2 + H2O. IEA GO:0004089 carbonate dehydratase activity GSVIVG01033673001 18771817 18775120 GO:0006730 one-carbon metabolic process The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01018919001 18646489 18655154 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01018992001 18009481 18011045 GSVIVG01005645001 20826318 20826686 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA GSVIVG01005645001 20826318 20826686 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA GSVIVG01036013001 7189959 7192597 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01010646001 15651418 15654393 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010646001 15651418 15654393 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010646001 15651418 15654393 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01010646001 15651418 15654393 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01010646001 15651418 15654393 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01010646001 15651418 15654393 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01010646001 15651418 15654393 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01010646001 15651418 15654393 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01010646001 15651418 15654393 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01010646001 15651418 15654393 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01010646001 15651418 15654393 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01010646001 15651418 15654393 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01038287001 24985107 24985426 GO:0007205 activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway The initiation of the activity of the inactive enzyme protein kinase C as the result of a series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol 3-phosphate. IEA GO:0004143 diacylglycerol kinase activity GSVIVG01022978001 17344569 17345999 GSVIVG01003601001 11166169 11170885 GSVIVG01017698001 2741660 2747844 GSVIVG01001351001 23869367 23870145 GSVIVG01009212001 6273222 6275070 GSVIVG01024524001 9234280 9237428 GSVIVG01003720001 7373296 7375644 GSVIVG01009798001 11331768 11334980 Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01011847001 3668620 3670737 GO:0006541 glutamine metabolic process The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01035422001 1195165 1195831 GSVIVG01036874001 18359522 18364201 GSVIVG01031668001 19895340 19909576 GO:0006303 double-strand break repair via nonhomologous end joining The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01031668001 19895340 19909576 GO:0006303 double-strand break repair via nonhomologous end joining The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. IEA GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex A large protein complex which is involved in the repair of DNA double-strand breaks and, in mammals, V(D)J recombination events. It consists of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs), the DNA end-binding heterodimer Ku, the nuclear phosphoprotein XRCC4 or a homolog thereof, and DNA ligase IV. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01031668001 19895340 19909576 GO:0006303 double-strand break repair via nonhomologous end joining The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01031668001 19895340 19909576 GO:0006303 double-strand break repair via nonhomologous end joining The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. IEA GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex A large protein complex which is involved in the repair of DNA double-strand breaks and, in mammals, V(D)J recombination events. It consists of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs), the DNA end-binding heterodimer Ku, the nuclear phosphoprotein XRCC4 or a homolog thereof, and DNA ligase IV. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01031668001 19895340 19909576 GO:0006303 double-strand break repair via nonhomologous end joining The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate, driving the unwinding of the DNA helix. IEA GO:0004003 ATP-dependent DNA helicase activity GSVIVG01031668001 19895340 19909576 GO:0006303 double-strand break repair via nonhomologous end joining The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. IEA GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex A large protein complex which is involved in the repair of DNA double-strand breaks and, in mammals, V(D)J recombination events. It consists of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs), the DNA end-binding heterodimer Ku, the nuclear phosphoprotein XRCC4 or a homolog thereof, and DNA ligase IV. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate, driving the unwinding of the DNA helix. IEA GO:0004003 ATP-dependent DNA helicase activity GSVIVG01031668001 19895340 19909576 GO:0006303 double-strand break repair via nonhomologous end joining The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031668001 19895340 19909576 GO:0006303 double-strand break repair via nonhomologous end joining The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. IEA GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex A large protein complex which is involved in the repair of DNA double-strand breaks and, in mammals, V(D)J recombination events. It consists of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs), the DNA end-binding heterodimer Ku, the nuclear phosphoprotein XRCC4 or a homolog thereof, and DNA ligase IV. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032857001 191856 194325 GO:0006414 translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01032857001 191856 194325 GO:0006414 translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01032857001 191856 194325 GO:0042254 ribosome biogenesis The process of the formation of the constituents of the ribosome subunits, their assembly, and their transport to the sites of protein synthesis. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01032857001 191856 194325 GO:0042254 ribosome biogenesis The process of the formation of the constituents of the ribosome subunits, their assembly, and their transport to the sites of protein synthesis. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01007972001 7058124 7059527 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01012176001 760231 762137 GSVIVG01000721001 180237 182941 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01000721001 180237 182941 GO:0009734 auxin mediated signaling pathway The series of molecular signals generated in response to detection of auxin. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01000721001 180237 182941 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01016123001 19484829 19497310 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016123001 19484829 19497310 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01000020001 2856608 2864653 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000020001 2856608 2864653 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01016738001 811736 816741 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01016738001 811736 816741 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: linoleate + O2 = (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate. IEA GO:0016165 lipoxygenase activity GSVIVG01016738001 811736 816741 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor. IEA GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen GSVIVG01016738001 811736 816741 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01013170001 7190724 7217114 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01013170001 7190724 7217114 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01013170001 7190724 7217114 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the reaction: ATP + pyruvate = ADP + phosphoenolpyruvate. IEA GO:0004743 pyruvate kinase activity GSVIVG01013170001 7190724 7217114 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Interacting selectively and non-covalently with potassium (K+) ions. IEA GO:0030955 potassium ion binding GSVIVG01033684001 18700548 18702608 GSVIVG01021897001 5857910 5919071 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01021897001 5857910 5919071 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01007070001 30035450 30035671 GSVIVG01033976001 16158348 16161811 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033976001 16158348 16161811 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01015577001 5128838 5129607 GSVIVG01032606001 28786100 28790106 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01014988001 12707 15143 GSVIVG01004848001 14138 14770 GSVIVG01025947001 26843051 26848844 GSVIVG01014705001 8806002 8809821 GSVIVG01037820001 7502149 7502253 GSVIVG01030797001 16241298 16243057 GSVIVG01029790001 14716424 14719367 GSVIVG01011855001 3533500 3547783 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01011855001 3533500 3547783 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01011855001 3533500 3547783 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01011855001 3533500 3547783 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01012511001 342199 344362 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026919001 19400546 19405316 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion. IEA GO:0004091 carboxylesterase activity GSVIVG01026919001 19400546 19405316 GO:0016042 lipid catabolic process The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion. IEA GO:0004091 carboxylesterase activity GSVIVG01026919001 19400546 19405316 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion. IEA GO:0004806 triglyceride lipase activity GSVIVG01026919001 19400546 19405316 GO:0016042 lipid catabolic process The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion. IEA GO:0004806 triglyceride lipase activity GSVIVG01023680001 9048757 9049604 GO:0005992 trehalose biosynthetic process The chemical reactions and pathways resulting in the formation of trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01037253001 16887912 16893314 GSVIVG01023470001 11334869 11340881 GSVIVG01017630001 2142657 2145832 GSVIVG01003653001 11746434 11747437 GSVIVG01008644001 179331 181160 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01022392001 19580451 19581940 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01036492001 22639532 22640532 GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA GSVIVG01013770001 7746064 7751765 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01013770001 7746064 7751765 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01013770001 7746064 7751765 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA A ligand-dependent receptor found in the nucleus of the cell. IEA GO:0004879 ligand-dependent nuclear receptor activity GSVIVG01033475001 20388585 20393359 GO:0006284 base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01033475001 20388585 20393359 GO:0006284 base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033475001 20388585 20393359 GO:0006284 base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. IEA Catalysis of the hydrolysis of alkylated DNA; recognizes and removes alkylated purines and pyrimidines by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic or apyrimidinic (AP) site. Enzyme has broad substrate specificity, being able to recognize alkylpurines, alkylpyrimidines or ethenopurines. IEA GO:0003905 alkylbase DNA N-glycosylase activity GSVIVG01022347001 18802181 18814491 GSVIVG01016958001 2972405 2977934 GSVIVG01017485001 9154299 9154565 GSVIVG01035318001 409522 413243 GSVIVG01024994001 5418081 5420685 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010161001 16584264 16590008 GSVIVG01001308001 5202974 5204512 GSVIVG01023932001 2403127 2409026 GSVIVG01019978001 12066061 12085003 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01000700001 15810821 15811240 GSVIVG01008797001 2177337 2196765 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01015981001 16756673 16757283 GSVIVG01011328001 8542535 8558516 GO:0007205 activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway The initiation of the activity of the inactive enzyme protein kinase C as the result of a series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol 3-phosphate. IEA GO:0004143 diacylglycerol kinase activity GSVIVG01011791001 4113895 4115778 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01026466001 23110638 23112150 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01026466001 23110638 23112150 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01007548001 12313634 12324023 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01009007001 4220983 4221999 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01009007001 4220983 4221999 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01016830001 1748825 1754176 GSVIVG01031488001 17991721 17994476 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004185 serine-type carboxypeptidase activity GSVIVG01017659001 2419711 2422722 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01023488001 11054335 11055967 GSVIVG01038519001 10909100 10909219 GSVIVG01014007001 8848898 8852498 GSVIVG01033387001 21026051 21026913 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033387001 21026051 21026913 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033387001 21026051 21026913 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01033387001 21026051 21026913 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01033387001 21026051 21026913 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033387001 21026051 21026913 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033387001 21026051 21026913 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033387001 21026051 21026913 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01019209001 3393823 3425993 GSVIVG01006501001 42379327 42379837 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01006501001 42379327 42379837 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010457001 20752678 20755355 GSVIVG01014120001 549308 557539 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01037216001 27892345 27911348 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01037216001 27892345 27911348 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01037216001 27892345 27911348 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01017770001 3311939 3336770 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01017770001 3311939 3336770 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01020139001 9913386 9925205 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0043231 intracellular membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. IEA Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2. IEA GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity GSVIVG01020139001 9913386 9925205 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0043231 intracellular membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. IEA Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2. IEA GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity GSVIVG01020139001 9913386 9925205 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0043231 intracellular membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. IEA Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2. IEA GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity GSVIVG01020139001 9913386 9925205 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0043231 intracellular membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. IEA Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide. IEA GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor GSVIVG01020139001 9913386 9925205 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0043231 intracellular membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. IEA Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide. IEA GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor GSVIVG01020139001 9913386 9925205 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0043231 intracellular membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. IEA Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide. IEA GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor GSVIVG01026612001 21026431 21027195 GSVIVG01018858001 19181536 19187429 GO:0006400 tRNA modification The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically. IEA GO:0005575 cellular_component The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018858001 19181536 19187429 GO:0006400 tRNA modification The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018858001 19181536 19187429 GO:0009451 RNA modification The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. IEA GO:0005575 cellular_component The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018858001 19181536 19187429 GO:0009451 RNA modification The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018858001 19181536 19187429 GO:0006400 tRNA modification The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically. IEA GO:0005575 cellular_component The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01018858001 19181536 19187429 GO:0006400 tRNA modification The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01018858001 19181536 19187429 GO:0009451 RNA modification The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. IEA GO:0005575 cellular_component The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01018858001 19181536 19187429 GO:0009451 RNA modification The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01018858001 19181536 19187429 GO:0006400 tRNA modification The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically. IEA GO:0005575 cellular_component The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01018858001 19181536 19187429 GO:0006400 tRNA modification The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01018858001 19181536 19187429 GO:0009451 RNA modification The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. IEA GO:0005575 cellular_component The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01018858001 19181536 19187429 GO:0009451 RNA modification The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01018858001 19181536 19187429 GO:0006400 tRNA modification The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically. IEA GO:0005575 cellular_component The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together. IEA Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051539 4 iron, 4 sulfur cluster binding GSVIVG01018858001 19181536 19187429 GO:0006400 tRNA modification The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051539 4 iron, 4 sulfur cluster binding GSVIVG01018858001 19181536 19187429 GO:0009451 RNA modification The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. IEA GO:0005575 cellular_component The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together. IEA Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051539 4 iron, 4 sulfur cluster binding GSVIVG01018858001 19181536 19187429 GO:0009451 RNA modification The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051539 4 iron, 4 sulfur cluster binding GSVIVG01033038001 25252455 25258083 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035604001 2639715 2646512 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01037584001 10607903 10608361 GSVIVG01009588001 9680993 9686126 GSVIVG01020564001 4282164 4298874 GO:0019856 pyrimidine base biosynthetic process The chemical reactions and pathways resulting in the formation of pyrimidine bases, 1,3-diazine, organic nitrogenous bases. IEA Catalysis of the reaction: (S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate. IEA GO:0004151 dihydroorotase activity GSVIVG01020564001 4282164 4298874 GO:0019856 pyrimidine base biosynthetic process The chemical reactions and pathways resulting in the formation of pyrimidine bases, 1,3-diazine, organic nitrogenous bases. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01020564001 4282164 4298874 GO:0019856 pyrimidine base biosynthetic process The chemical reactions and pathways resulting in the formation of pyrimidine bases, 1,3-diazine, organic nitrogenous bases. IEA Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amide. IEA GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides GSVIVG01020564001 4282164 4298874 GO:0019856 pyrimidine base biosynthetic process The chemical reactions and pathways resulting in the formation of pyrimidine bases, 1,3-diazine, organic nitrogenous bases. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01032189001 21718336 21723551 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01032189001 21718336 21723551 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01032189001 21718336 21723551 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032189001 21718336 21723551 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032189001 21718336 21723551 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032189001 21718336 21723551 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023230001 20910314 20915462 GSVIVG01000715001 128385 130193 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019836001 3775419 3776265 GSVIVG01012174001 763145 767420 GSVIVG01036957001 9553245 9614269 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01022137001 16861134 16865806 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01033577001 19618568 19620760 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor. IEA GO:0004368 glycerol-3-phosphate dehydrogenase activity GSVIVG01033577001 19618568 19620760 GO:0016117 carotenoid biosynthetic process The chemical reactions and pathways resulting in the formation of carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor. IEA GO:0004368 glycerol-3-phosphate dehydrogenase activity GSVIVG01033577001 19618568 19620760 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor. IEA GO:0004368 glycerol-3-phosphate dehydrogenase activity GSVIVG01033577001 19618568 19620760 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. IEA GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GSVIVG01033577001 19618568 19620760 GO:0016117 carotenoid biosynthetic process The chemical reactions and pathways resulting in the formation of carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. IEA GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GSVIVG01033577001 19618568 19620760 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. IEA GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GSVIVG01008061001 6154649 6156718 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01032160001 21997444 22010928 Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate. IEA GO:0008146 sulfotransferase activity GSVIVG01016781001 1304559 1316065 GSVIVG01035543001 2154427 2164647 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar. IEA GO:0008375 acetylglucosaminyltransferase activity GSVIVG01024347001 1267765 1282259 GSVIVG01022243001 17783211 17784041 GSVIVG01009179001 5822106 5822793 GSVIVG01001853001 11192 12931 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals. IEA GO:0008519 ammonium transmembrane transporter activity GSVIVG01001853001 11192 12931 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals. IEA GO:0008519 ammonium transmembrane transporter activity GSVIVG01009577001 9571950 9578441 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01009577001 9571950 9578441 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01023272001 20268074 20268703 GSVIVG01020651001 3444745 3447702 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01020651001 3444745 3447702 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01020651001 3444745 3447702 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01020651001 3444745 3447702 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01020651001 3444745 3447702 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01020651001 3444745 3447702 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020651001 3444745 3447702 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020651001 3444745 3447702 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020651001 3444745 3447702 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020651001 3444745 3447702 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020651001 3444745 3447702 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01020651001 3444745 3447702 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01020651001 3444745 3447702 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01020651001 3444745 3447702 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01020651001 3444745 3447702 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01000780001 73508 82770 GO:0009116 nucleoside metabolic process The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine). IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01000780001 73508 82770 GO:0009165 nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates). IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01000780001 73508 82770 GO:0009116 nucleoside metabolic process The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine). IEA Catalysis of the reaction: ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate. IEA GO:0004749 ribose phosphate diphosphokinase activity GSVIVG01000780001 73508 82770 GO:0009165 nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates). IEA Catalysis of the reaction: ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate. IEA GO:0004749 ribose phosphate diphosphokinase activity GSVIVG01001269001 4861965 4864774 GSVIVG01038013001 12576649 12582077 GSVIVG01035915001 5740294 5744083 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01035915001 5740294 5744083 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01035915001 5740294 5744083 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids. IEA GO:0004518 nuclease activity GSVIVG01035915001 5740294 5744083 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids. IEA GO:0004518 nuclease activity GSVIVG01035915001 5740294 5744083 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01035915001 5740294 5744083 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01035915001 5740294 5744083 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01035915001 5740294 5744083 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01035915001 5740294 5744083 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01035915001 5740294 5744083 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01035915001 5740294 5744083 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035915001 5740294 5744083 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025892001 27434977 27437128 GSVIVG01017009001 3412001 3414418 GSVIVG01019993001 11873303 11874933 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01013850001 5200379 5206089 GO:0006801 superoxide metabolic process The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species. IEA Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + H2O2. IEA GO:0004784 superoxide dismutase activity GSVIVG01013850001 5200379 5206089 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + H2O2. IEA GO:0004784 superoxide dismutase activity GSVIVG01013850001 5200379 5206089 GO:0006801 superoxide metabolic process The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01013850001 5200379 5206089 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01018101001 6548340 6550725 The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01029461001 22597050 22602216 GSVIVG01019028001 17584686 17588252 GSVIVG01017842001 3956953 3960217 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01017842001 3956953 3960217 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01017842001 3956953 3960217 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01017842001 3956953 3960217 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021778001 10951472 10975230 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01003624001 403774 403971 GSVIVG01033033001 25221541 25224198 GO:0006071 glycerol metabolic process The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. IEA Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. IEA GO:0008081 phosphoric diester hydrolase activity GSVIVG01033033001 25221541 25224198 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. IEA GO:0008081 phosphoric diester hydrolase activity GSVIVG01033033001 25221541 25224198 GO:0006071 glycerol metabolic process The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. IEA Catalysis of the reaction: a glycerophosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate. IEA GO:0008889 glycerophosphodiester phosphodiesterase activity GSVIVG01033033001 25221541 25224198 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: a glycerophosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate. IEA GO:0008889 glycerophosphodiester phosphodiesterase activity GSVIVG01024830001 6572639 6574657 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01024830001 6572639 6574657 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01024830001 6572639 6574657 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01014968001 13238504 13239196 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009522 photosystem I A photosystem that contains an iron-sulfur reaction center associated with accessory pigments and electron carriers. In cyanobacteria and chloroplasts, photosystem I functions as a light-dependent plastocyanin-ferredoxin oxidoreductase, transferring electrons from plastocyanin to ferredoxin; in photosynthetic bacteria that have only a single type I photosystem, such as the green sulfur bacteria, electrons can go either to ferredoxin (Fd) -> NAD+ or to menaquinone (MK) -> Cytb/FeS -> Cytc555 -> photosystem I (cyclic photophosphorylation). IEA GSVIVG01014968001 13238504 13239196 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009579 thylakoid A membranous cellular structure that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the plasma membrane. In eukaryotes they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation. IEA GSVIVG01014968001 13238504 13239196 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01014182001 1302568 1319687 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024726001 7426440 7432205 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024726001 7426440 7432205 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01010984001 2438458 2439305 GSVIVG01030119001 10009089 10015865 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016615001 2428933 2430718 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01016615001 2428933 2430718 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01016615001 2428933 2430718 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01016615001 2428933 2430718 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01006691001 27575815 27576146 GSVIVG01023704001 9699882 9702261 GSVIVG01008267001 3799065 3805978 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01027521001 16004435 16007783 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01007676001 10586377 10594899 GSVIVG01004133001 15165092 15166449 GSVIVG01036732001 23206320 23207782 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01036732001 23206320 23207782 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01036732001 23206320 23207782 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036732001 23206320 23207782 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036732001 23206320 23207782 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01036732001 23206320 23207782 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01009525001 9062319 9064713 GSVIVG01019484001 1020201 1030408 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01019484001 1020201 1030408 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01021865001 6289018 6362143 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01021865001 6289018 6362143 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01021865001 6289018 6362143 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end. IEA GO:0004527 exonuclease activity GSVIVG01021865001 6289018 6362143 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end. IEA GO:0004527 exonuclease activity GSVIVG01021865001 6289018 6362143 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of an RNA molecule. IEA GO:0004534 5'-3' exoribonuclease activity GSVIVG01021865001 6289018 6362143 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of an RNA molecule. IEA GO:0004534 5'-3' exoribonuclease activity GSVIVG01021865001 6289018 6362143 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01021865001 6289018 6362143 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01010857001 16792701 16792829 GSVIVG01036997001 9120045 9130663 GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA GSVIVG01010221001 17826902 17827540 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01010221001 17826902 17827540 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01032342001 15313299 15313751 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with vasopressin to initiate a change in cell activity. IEA GO:0005000 vasopressin receptor activity GSVIVG01003576001 10819286 10821434 GSVIVG01010540001 16810875 16818602 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01010540001 16810875 16818602 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01010540001 16810875 16818602 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01010540001 16810875 16818602 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01010540001 16810875 16818602 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01010540001 16810875 16818602 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01010540001 16810875 16818602 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Interacting selectively and non-covalently with chromatin, the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase. IEA GO:0003682 chromatin binding GSVIVG01010540001 16810875 16818602 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with chromatin, the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase. IEA GO:0003682 chromatin binding GSVIVG01010540001 16810875 16818602 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Interacting selectively and non-covalently with chromatin, the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase. IEA GO:0003682 chromatin binding GSVIVG01010540001 16810875 16818602 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with chromatin, the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase. IEA GO:0003682 chromatin binding GSVIVG01010540001 16810875 16818602 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Interacting selectively and non-covalently with chromatin, the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase. IEA GO:0003682 chromatin binding GSVIVG01010540001 16810875 16818602 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with chromatin, the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase. IEA GO:0003682 chromatin binding GSVIVG01010540001 16810875 16818602 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Interacting selectively and non-covalently with single-stranded DNA. IEA GO:0003697 single-stranded DNA binding GSVIVG01010540001 16810875 16818602 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with single-stranded DNA. IEA GO:0003697 single-stranded DNA binding GSVIVG01010540001 16810875 16818602 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Interacting selectively and non-covalently with single-stranded DNA. IEA GO:0003697 single-stranded DNA binding GSVIVG01010540001 16810875 16818602 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with single-stranded DNA. IEA GO:0003697 single-stranded DNA binding GSVIVG01010540001 16810875 16818602 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Interacting selectively and non-covalently with single-stranded DNA. IEA GO:0003697 single-stranded DNA binding GSVIVG01010540001 16810875 16818602 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with single-stranded DNA. IEA GO:0003697 single-stranded DNA binding GSVIVG01010540001 16810875 16818602 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010540001 16810875 16818602 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010540001 16810875 16818602 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010540001 16810875 16818602 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010540001 16810875 16818602 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010540001 16810875 16818602 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010540001 16810875 16818602 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids. IEA GO:0004518 nuclease activity GSVIVG01010540001 16810875 16818602 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids. IEA GO:0004518 nuclease activity GSVIVG01010540001 16810875 16818602 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids. IEA GO:0004518 nuclease activity GSVIVG01010540001 16810875 16818602 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids. IEA GO:0004518 nuclease activity GSVIVG01010540001 16810875 16818602 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids. IEA GO:0004518 nuclease activity GSVIVG01010540001 16810875 16818602 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids. IEA GO:0004518 nuclease activity GSVIVG01010540001 16810875 16818602 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. IEA GO:0004519 endonuclease activity GSVIVG01010540001 16810875 16818602 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. IEA GO:0004519 endonuclease activity GSVIVG01010540001 16810875 16818602 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. IEA GO:0004519 endonuclease activity GSVIVG01010540001 16810875 16818602 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. IEA GO:0004519 endonuclease activity GSVIVG01010540001 16810875 16818602 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. IEA GO:0004519 endonuclease activity GSVIVG01010540001 16810875 16818602 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. IEA GO:0004519 endonuclease activity GSVIVG01015439001 3695731 3697125 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01022210001 17492339 17523059 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01022210001 17492339 17523059 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021328001 4083510 4086308 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01021328001 4083510 4086308 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01000718001 146252 154311 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01000718001 146252 154311 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01034648001 13413304 13416367 GSVIVG01001087001 22527463 22544554 GSVIVG01011134001 7079389 7080363 GSVIVG01022283001 18184062 18194607 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01007471001 32132764 32136143 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01007471001 32132764 32136143 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01007471001 32132764 32136143 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01003250001 8337131 8340440 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01003250001 8337131 8340440 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01011706001 4920369 4928008 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01007450001 32006334 32007177 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GSVIVG01026619001 20975648 20978345 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01026619001 20975648 20978345 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01026619001 20975648 20978345 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01038226001 24476924 24479567 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01038226001 24476924 24479567 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01038226001 24476924 24479567 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01038226001 24476924 24479567 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01038226001 24476924 24479567 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01038226001 24476924 24479567 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01038226001 24476924 24479567 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01038226001 24476924 24479567 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033564001 19732585 19734964 GSVIVG01032125001 22429417 22429671 GSVIVG01007063001 29964973 29968054 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01007063001 29964973 29968054 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01007063001 29964973 29968054 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01008925001 3422179 3424178 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01015402001 3298356 3299653 GSVIVG01023310001 19802763 19804902 GSVIVG01034881001 15866681 15868604 GSVIVG01002210001 33378103 33379907 GSVIVG01018062001 6022842 6024227 GSVIVG01017973001 5203551 5209684 GO:0000105 histidine biosynthetic process The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O. IEA GO:0004424 imidazoleglycerol-phosphate dehydratase activity GSVIVG01017973001 5203551 5209684 GO:0000105 histidine biosynthetic process The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01026410001 23835410 23843626 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin. IEA GO:0004221 ubiquitin thiolesterase activity GSVIVG01001019001 20136079 20136309 GSVIVG01012338001 443553 443657 GSVIVG01016567001 2720318 2723714 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018128001 6800301 6804756 GSVIVG01005289001 20219733 20219873 GSVIVG01037014001 8915655 8927983 GO:0019538 protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide. IEA GO:0016671 oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor GSVIVG01037014001 8915655 8927983 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide. IEA GO:0016671 oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor GSVIVG01004312001 38038817 38039982 GSVIVG01012573001 3886868 3922235 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01033290001 21780024 21782332 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GSVIVG01027043001 18402521 18407289 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule. IEA GO:0000175 3'-5'-exoribonuclease activity GSVIVG01027043001 18402521 18407289 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01006022001 23190305 23191587 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01034617001 14222002 14232955 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01034617001 14222002 14232955 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01008517001 1190773 1197806 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01008517001 1190773 1197806 GO:0009116 nucleoside metabolic process The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine). IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01008517001 1190773 1197806 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: ATP + uridine = ADP + UMP. IEA GO:0004849 uridine kinase activity GSVIVG01008517001 1190773 1197806 GO:0009116 nucleoside metabolic process The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine). IEA Catalysis of the reaction: ATP + uridine = ADP + UMP. IEA GO:0004849 uridine kinase activity GSVIVG01008517001 1190773 1197806 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008517001 1190773 1197806 GO:0009116 nucleoside metabolic process The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine). IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008517001 1190773 1197806 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: ATP + D-ribulose 5-phosphate = ADP + D-ribulose 1,5-bisphosphate. IEA GO:0008974 phosphoribulokinase activity GSVIVG01008517001 1190773 1197806 GO:0009116 nucleoside metabolic process The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine). IEA Catalysis of the reaction: ATP + D-ribulose 5-phosphate = ADP + D-ribulose 1,5-bisphosphate. IEA GO:0008974 phosphoribulokinase activity GSVIVG01008517001 1190773 1197806 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01008517001 1190773 1197806 GO:0009116 nucleoside metabolic process The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine). IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01008517001 1190773 1197806 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01008517001 1190773 1197806 GO:0009116 nucleoside metabolic process The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine). IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01008517001 1190773 1197806 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01008517001 1190773 1197806 GO:0009116 nucleoside metabolic process The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine). IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01008517001 1190773 1197806 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01008517001 1190773 1197806 GO:0009116 nucleoside metabolic process The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine). IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01000592001 6744493 6746449 GSVIVG01034287001 14087204 14088154 GSVIVG01012789001 23250911 23258890 GSVIVG01025174001 3710595 3712907 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01015808001 17711834 17712934 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015808001 17711834 17712934 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036578001 18494725 18500160 GSVIVG01001227001 1616711 1618981 GSVIVG01013543001 20457099 20457704 GSVIVG01033551001 19821737 19828462 GO:0008380 RNA splicing The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA. IEA GSVIVG01001205001 815450 816819 GSVIVG01031707001 3594413 3603340 GSVIVG01033921001 16717001 16730121 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01026470001 23045582 23049328 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide. IEA GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor GSVIVG01030777001 15824618 15824977 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019887001 4234843 4244059 GSVIVG01017010001 3414695 3425101 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01017010001 3414695 3425101 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01017010001 3414695 3425101 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01017010001 3414695 3425101 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01017010001 3414695 3425101 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01017010001 3414695 3425101 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01023651001 8481408 8483743 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01030131001 10118700 10119638 GSVIVG01029293001 17410490 17415407 GO:0046836 glycolipid transport The directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Enables the directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of, within or between cells. IEA GO:0017089 glycolipid transporter activity GSVIVG01029293001 17410490 17415407 GO:0046836 glycolipid transport The directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a glycolipid, any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic moiety such as an acylglycerol, a sphingoid, a ceramide (N-acylsphingoid) or a prenyl phosphate. IEA GO:0051861 glycolipid binding GSVIVG01016452001 3768030 3771501 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01016452001 3768030 3771501 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01016452001 3768030 3771501 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01016452001 3768030 3771501 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01036343001 3963736 3982165 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01036343001 3963736 3982165 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01036343001 3963736 3982165 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01036343001 3963736 3982165 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01032095001 22757578 22760111 GSVIVG01018945001 18459754 18488584 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01018945001 18459754 18488584 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018945001 18459754 18488584 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01028729001 19346927 19354509 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01028729001 19346927 19354509 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01011354001 28912919 28915800 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004185 serine-type carboxypeptidase activity GSVIVG01000053001 3110690 3113957 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01000053001 3110690 3113957 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01009726001 10823527 10825411 GSVIVG01017468001 8843749 8856391 GSVIVG01005273001 20121499 20129908 GSVIVG01008016001 6661141 6663435 GSVIVG01028824001 18338891 18344393 GSVIVG01001674001 14136506 14140433 GSVIVG01020817001 1616286 1619292 GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA GSVIVG01009344001 7574565 7580096 GSVIVG01015050001 715665 717896 GSVIVG01037893001 6623124 6623416 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA GSVIVG01037893001 6623124 6623416 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01030417001 5410607 5418653 GSVIVG01020858001 931629 933319 GO:0009765 photosynthesis, light harvesting Absorption and transfer of the energy absorbed from light photons between photosystem reaction centers. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01022937001 17812003 17813011 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009518001 9012573 9022220 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01023241001 20755242 20760026 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01023241001 20755242 20760026 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01023241001 20755242 20760026 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01009649001 10206683 10206766 GSVIVG01032535001 28151702 28153164 GSVIVG01019417001 495266 504962 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01016556001 2804099 2807709 GSVIVG01012496001 13920148 13926541 GSVIVG01017731001 2991071 2993240 GSVIVG01022654001 14158544 14163767 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01008188001 4833306 4884217 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01008188001 4833306 4884217 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01008188001 4833306 4884217 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01008188001 4833306 4884217 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01008188001 4833306 4884217 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01008188001 4833306 4884217 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01008188001 4833306 4884217 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe). IEA GO:0004826 phenylalanine-tRNA ligase activity GSVIVG01008188001 4833306 4884217 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe). IEA GO:0004826 phenylalanine-tRNA ligase activity GSVIVG01008188001 4833306 4884217 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008188001 4833306 4884217 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024896001 6173472 6184530 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024896001 6173472 6184530 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024896001 6173472 6184530 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024896001 6173472 6184530 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024896001 6173472 6184530 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024896001 6173472 6184530 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016980001 3133979 3155012 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01036470001 22426521 22468815 GSVIVG01025725001 12619688 12632202 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019144001 16238302 16252399 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019144001 16238302 16252399 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01025229001 2996460 3008274 GO:0006875 cellular metal ion homeostasis Any process involved in the maintenance of an internal steady-state of metal ions at the level of a cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037864001 6995096 6998539 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01007984001 6967307 6971068 GSVIVG01026244001 14726735 14731504 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004185 serine-type carboxypeptidase activity GSVIVG01025034001 5103135 5104260 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01015030001 583452 584708 GSVIVG01016200001 6684546 6691346 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GSVIVG01004931001 21601487 21610278 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01004931001 21601487 21610278 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Catalysis of the transfer of a nucleotidyl group to a reactant. IEA GO:0016779 nucleotidyltransferase activity GSVIVG01008201001 4726335 4732295 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008201001 4726335 4732295 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008456001 1830227 1832876 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01008456001 1830227 1832876 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008456001 1830227 1832876 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01008456001 1830227 1832876 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01023957001 2169180 2183369 GO:0008299 isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01007726001 9888229 9891951 GSVIVG01009351001 7618241 7623443 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009351001 7618241 7623443 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009351001 7618241 7623443 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009351001 7618241 7623443 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009351001 7618241 7623443 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009351001 7618241 7623443 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009351001 7618241 7623443 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01009351001 7618241 7623443 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01009351001 7618241 7623443 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01015318001 2656223 2657662 GSVIVG01010003001 13365474 13366663 Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01010003001 13365474 13366663 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01017433001 8468227 8470808 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: diphosphate + H2O = 2 phosphate. IEA GO:0004427 inorganic diphosphatase activity GSVIVG01017433001 8468227 8470808 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: diphosphate + H2O = 2 phosphate. IEA GO:0004427 inorganic diphosphatase activity GSVIVG01017433001 8468227 8470808 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: diphosphate + H2O = 2 phosphate. IEA GO:0004427 inorganic diphosphatase activity GSVIVG01017433001 8468227 8470808 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: diphosphate + H2O = 2 phosphate. IEA GO:0004427 inorganic diphosphatase activity GSVIVG01017433001 8468227 8470808 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: diphosphate + H2O = 2 phosphate. IEA GO:0004427 inorganic diphosphatase activity GSVIVG01017433001 8468227 8470808 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: diphosphate + H2O = 2 phosphate. IEA GO:0004427 inorganic diphosphatase activity GSVIVG01017433001 8468227 8470808 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of pyrophosphate, which generates a proton motive force. IEA GO:0009678 hydrogen-translocating pyrophosphatase activity GSVIVG01017433001 8468227 8470808 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of pyrophosphate, which generates a proton motive force. IEA GO:0009678 hydrogen-translocating pyrophosphatase activity GSVIVG01017433001 8468227 8470808 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of pyrophosphate, which generates a proton motive force. IEA GO:0009678 hydrogen-translocating pyrophosphatase activity GSVIVG01017433001 8468227 8470808 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of pyrophosphate, which generates a proton motive force. IEA GO:0009678 hydrogen-translocating pyrophosphatase activity GSVIVG01017433001 8468227 8470808 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of pyrophosphate, which generates a proton motive force. IEA GO:0009678 hydrogen-translocating pyrophosphatase activity GSVIVG01017433001 8468227 8470808 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of pyrophosphate, which generates a proton motive force. IEA GO:0009678 hydrogen-translocating pyrophosphatase activity GSVIVG01017433001 8468227 8470808 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01017433001 8468227 8470808 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01017433001 8468227 8470808 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01017433001 8468227 8470808 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01017433001 8468227 8470808 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01017433001 8468227 8470808 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01005094001 14487863 14489172 GSVIVG01009264001 6802505 6803965 GSVIVG01001329001 28094 28408 GSVIVG01001814001 26022257 26030015 GSVIVG01004464001 38691338 38692638 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025984001 26310665 26319306 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01025984001 26310665 26319306 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01025984001 26310665 26319306 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01025984001 26310665 26319306 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01008189001 4829690 4831828 GO:0006357 regulation of transcription from RNA polymerase II promoter Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. IEA GO:0016592 mediator complex A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. IEA Functions to mediate the interaction of transcriptional activators with the RNA polymerase II-general RNA polymerase II transcription factor complex. IEA GO:0016455 RNA polymerase II transcription mediator activity GSVIVG01010446001 20690929 20695341 Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01010446001 20690929 20695341 Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01025808001 11640866 11643056 GSVIVG01017293001 6432361 6433995 GSVIVG01027508001 16132617 16138896 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01027508001 16132617 16138896 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01027508001 16132617 16138896 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01027508001 16132617 16138896 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01027508001 16132617 16138896 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01027508001 16132617 16138896 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01027508001 16132617 16138896 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01027508001 16132617 16138896 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01023153001 21885266 21890625 GSVIVG01008744001 1623646 1667296 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008744001 1623646 1667296 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01000467001 8230907 8231473 GSVIVG01012550001 1184439 1185418 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01006234001 23817756 23839798 GSVIVG01034503001 20224369 20234931 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031469001 18236823 18238785 GSVIVG01001277001 4921780 4923609 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01000962001 22308446 22311511 GSVIVG01026772001 6825086 6827013 GSVIVG01027428001 16818393 16821084 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027428001 16818393 16821084 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: D-arabinono-1,4-lactone + O2 = dehydro-D-arabinono-1,4-lactone + H2O2. IEA GO:0003885 D-arabinono-1,4-lactone oxidase activity GSVIVG01027428001 16818393 16821084 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01027428001 16818393 16821084 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01021742001 10394734 10395045 GSVIVG01020023001 11464589 11467806 GSVIVG01019985001 11978786 11983285 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01019985001 11978786 11983285 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01013481001 1535255 1536443 GSVIVG01036070001 21054970 21057576 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01036070001 21054970 21057576 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01036070001 21054970 21057576 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01036070001 21054970 21057576 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01036070001 21054970 21057576 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01036070001 21054970 21057576 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01036070001 21054970 21057576 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01036070001 21054970 21057576 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01036070001 21054970 21057576 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01036070001 21054970 21057576 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01036070001 21054970 21057576 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01036070001 21054970 21057576 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01036070001 21054970 21057576 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01036070001 21054970 21057576 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01036070001 21054970 21057576 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033536001 19880679 19913822 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033536001 19880679 19913822 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01033536001 19880679 19913822 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01005215001 19276130 19281690 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01005215001 19276130 19281690 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: linoleate + O2 = (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate. IEA GO:0016165 lipoxygenase activity GSVIVG01005215001 19276130 19281690 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor. IEA GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen GSVIVG01005215001 19276130 19281690 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01024401001 2128403 2134515 GSVIVG01008918001 3387828 3389344 GSVIVG01013134001 7852463 7858844 GSVIVG01005204001 19177156 19182234 GO:0006075 1,3-beta-glucan biosynthetic process The chemical reactions and pathways resulting in the formation of beta-1,3 glucans, compounds composed of glucose residues linked by 1,3-beta-D-glucosidic bonds. IEA GO:0000148 1,3-beta-glucan synthase complex A protein complex that catalyzes the transfer of a glucose moiety from UDP-glucose to a 1,3-beta-D-glucan chain. IEA Catalysis of the reaction: UDP-glucose + 1,3-beta-D-glucosyl(n) = UDP + 1,3-beta-D-glucosyl(n+1). IEA GO:0003843 1,3-beta-glucan synthase activity GSVIVG01005204001 19177156 19182234 GO:0006075 1,3-beta-glucan biosynthetic process The chemical reactions and pathways resulting in the formation of beta-1,3 glucans, compounds composed of glucose residues linked by 1,3-beta-D-glucosidic bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: UDP-glucose + 1,3-beta-D-glucosyl(n) = UDP + 1,3-beta-D-glucosyl(n+1). IEA GO:0003843 1,3-beta-glucan synthase activity GSVIVG01029974001 2532108 2533420 GSVIVG01003748001 12336232 12339719 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01021399001 4919640 4923372 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01021399001 4919640 4923372 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01016334001 4881855 4885208 GSVIVG01012655001 383076 390459 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01012655001 383076 390459 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01012655001 383076 390459 GO:0016042 lipid catabolic process The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01012655001 383076 390459 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012655001 383076 390459 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012655001 383076 390459 GO:0016042 lipid catabolic process The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012655001 383076 390459 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01012655001 383076 390459 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01012655001 383076 390459 GO:0016042 lipid catabolic process The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01008859001 2875900 2876019 GSVIVG01009475001 8682892 8684629 GSVIVG01011707001 4918966 4920189 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule. IEA GO:0016655 oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor GSVIVG01037572001 10952218 10963144 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01035674001 3197530 3199397 GSVIVG01037107001 29086519 29097009 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01037107001 29086519 29097009 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01037107001 29086519 29097009 Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01023578001 9395856 9397231 GSVIVG01028103001 3832976 3835753 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028103001 3832976 3835753 Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01008106001 5753655 5754587 GO:0009405 pathogenesis The set of specific processes that generate the ability of an organism to cause disease in another. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA GSVIVG01037806001 7716202 7726782 GSVIVG01017135001 4496850 4496969 GSVIVG01001297001 5131036 5131778 GO:0006869 lipid transport The directed movement of lipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GSVIVG01000293001 2501943 2502864 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01000293001 2501943 2502864 Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium. IEA GO:0005544 calcium-dependent phospholipid binding GSVIVG01014832001 10326386 10327742 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with transfer RNA. IEA GO:0000049 tRNA binding GSVIVG01014832001 10326386 10327742 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe). IEA GO:0004826 phenylalanine-tRNA ligase activity GSVIVG01014832001 10326386 10327742 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010556001 16682417 16684337 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010556001 16682417 16684337 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010556001 16682417 16684337 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01010556001 16682417 16684337 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01025090001 4587042 4593381 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01022569001 5188160 5192937 GSVIVG01034675001 7495438 7499989 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01034675001 7495438 7499989 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01034675001 7495438 7499989 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034675001 7495438 7499989 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038602001 21583560 21588492 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01038602001 21583560 21588492 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01038653001 21175295 21178118 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01038653001 21175295 21178118 Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. IEA GO:0008171 O-methyltransferase activity GSVIVG01038653001 21175295 21178118 Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01038653001 21175295 21178118 The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01031006001 20731847 20739907 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01031006001 20731847 20739907 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01031006001 20731847 20739907 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01031006001 20731847 20739907 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01031006001 20731847 20739907 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01031006001 20731847 20739907 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01031006001 20731847 20739907 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01031006001 20731847 20739907 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01019533001 1403544 1404804 GSVIVG01036238001 8288918 8294668 GSVIVG01034971001 556699 558344 GSVIVG01031872001 5021076 5026440 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01031872001 5021076 5026440 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01031872001 5021076 5026440 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01031872001 5021076 5026440 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01003987001 26490520 26490920 GSVIVG01001876001 6578019 6578630 GSVIVG01027617001 15034095 15043467 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01032014001 23554168 23560529 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032014001 23554168 23560529 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01032014001 23554168 23560529 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01018265001 12288192 12296641 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018265001 12288192 12296641 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018265001 12288192 12296641 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018265001 12288192 12296641 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018265001 12288192 12296641 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018265001 12288192 12296641 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018265001 12288192 12296641 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018265001 12288192 12296641 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018265001 12288192 12296641 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018265001 12288192 12296641 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018265001 12288192 12296641 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018265001 12288192 12296641 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018265001 12288192 12296641 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01018265001 12288192 12296641 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01018265001 12288192 12296641 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01018265001 12288192 12296641 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01018265001 12288192 12296641 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01018265001 12288192 12296641 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01018265001 12288192 12296641 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01018265001 12288192 12296641 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01018265001 12288192 12296641 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01018265001 12288192 12296641 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01018265001 12288192 12296641 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01018265001 12288192 12296641 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01018265001 12288192 12296641 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01018265001 12288192 12296641 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01018265001 12288192 12296641 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01018265001 12288192 12296641 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01018265001 12288192 12296641 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01018265001 12288192 12296641 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01000248001 20506449 20508060 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01000248001 20506449 20508060 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01000248001 20506449 20508060 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01000248001 20506449 20508060 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01029552001 21675424 21679590 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01029552001 21675424 21679590 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01025186001 3589136 3594200 GSVIVG01018758001 20127272 20128591 GSVIVG01000929001 22022632 22023096 GSVIVG01020487001 18583209 18592268 GSVIVG01023677001 9016105 9019990 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01023677001 9016105 9019990 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01023677001 9016105 9019990 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01023677001 9016105 9019990 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023677001 9016105 9019990 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01004405001 38418945 38420758 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01009637001 10097950 10099041 GSVIVG01023812001 3293150 3300416 GO:0006231 dTMP biosynthetic process The chemical reactions and pathways resulting in the formation of dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate). IEA Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+. IEA GO:0004146 dihydrofolate reductase activity GSVIVG01023812001 3293150 3300416 GO:0006545 glycine biosynthetic process The chemical reactions and pathways resulting in the formation of glycine, aminoethanoic acid. IEA Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+. IEA GO:0004146 dihydrofolate reductase activity GSVIVG01023812001 3293150 3300416 GO:0006730 one-carbon metabolic process The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. IEA Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+. IEA GO:0004146 dihydrofolate reductase activity GSVIVG01023812001 3293150 3300416 GO:0009165 nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates). IEA Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+. IEA GO:0004146 dihydrofolate reductase activity GSVIVG01023812001 3293150 3300416 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+. IEA GO:0004146 dihydrofolate reductase activity GSVIVG01023812001 3293150 3300416 GO:0006231 dTMP biosynthetic process The chemical reactions and pathways resulting in the formation of dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate). IEA Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP. IEA GO:0004799 thymidylate synthase activity GSVIVG01023812001 3293150 3300416 GO:0006545 glycine biosynthetic process The chemical reactions and pathways resulting in the formation of glycine, aminoethanoic acid. IEA Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP. IEA GO:0004799 thymidylate synthase activity GSVIVG01023812001 3293150 3300416 GO:0006730 one-carbon metabolic process The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. IEA Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP. IEA GO:0004799 thymidylate synthase activity GSVIVG01023812001 3293150 3300416 GO:0009165 nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates). IEA Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP. IEA GO:0004799 thymidylate synthase activity GSVIVG01023812001 3293150 3300416 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP. IEA GO:0004799 thymidylate synthase activity GSVIVG01023812001 3293150 3300416 GO:0006231 dTMP biosynthetic process The chemical reactions and pathways resulting in the formation of dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate). IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01023812001 3293150 3300416 GO:0006545 glycine biosynthetic process The chemical reactions and pathways resulting in the formation of glycine, aminoethanoic acid. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01023812001 3293150 3300416 GO:0006730 one-carbon metabolic process The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01023812001 3293150 3300416 GO:0009165 nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates). IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01023812001 3293150 3300416 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01013810001 7333255 7336347 GSVIVG01036232001 8503896 8540242 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01034241001 13365541 13368529 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01034241001 13365541 13368529 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01034241001 13365541 13368529 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01034241001 13365541 13368529 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01034241001 13365541 13368529 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01034241001 13365541 13368529 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01034241001 13365541 13368529 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01034241001 13365541 13368529 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01034241001 13365541 13368529 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01034241001 13365541 13368529 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01034241001 13365541 13368529 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01034241001 13365541 13368529 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01030687001 13579146 13580506 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01038211001 24385240 24402464 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01026132001 12721993 12726590 GSVIVG01025502001 290039 291140 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01032529001 28112748 28132811 GO:0006506 GPI anchor biosynthetic process The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol moiety is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate moiety, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage. IEA GO:0005789 endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032529001 28112748 28132811 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005789 endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032529001 28112748 28132811 GO:0006506 GPI anchor biosynthetic process The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol moiety is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate moiety, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage. IEA GO:0005789 endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum. IEA Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of any sulfuric ester bond, any ester formed from sulfuric acid, O=SO(OH)2. IEA GO:0008484 sulfuric ester hydrolase activity GSVIVG01032529001 28112748 28132811 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005789 endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum. IEA Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of any sulfuric ester bond, any ester formed from sulfuric acid, O=SO(OH)2. IEA GO:0008484 sulfuric ester hydrolase activity GSVIVG01032529001 28112748 28132811 GO:0006506 GPI anchor biosynthetic process The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol moiety is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate moiety, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage. IEA GO:0005789 endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01032529001 28112748 28132811 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005789 endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01011923001 2967647 2980178 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01037002001 9080159 9083772 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01037002001 9080159 9083772 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01037002001 9080159 9083772 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01037002001 9080159 9083772 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01037002001 9080159 9083772 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037002001 9080159 9083772 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01029309001 17119307 17120830 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01031728001 3872536 3880620 Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01008645001 175746 178059 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01034127001 14983850 14990497 GSVIVG01011158001 7475779 7486645 Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. IEA GO:0016791 phosphatase activity GSVIVG01019048001 17385599 17388133 GSVIVG01028112001 3884106 3893367 GO:0006298 mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01028112001 3884106 3893367 GO:0006298 mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028112001 3884106 3893367 GO:0006298 mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. IEA Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches. IEA GO:0030983 mismatched DNA binding GSVIVG01023725001 10153683 10165966 GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O. IEA GO:0004129 cytochrome-c oxidase activity GSVIVG01015600001 5450480 5452866 GSVIVG01001689001 14293747 14294436 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01009871001 11972184 11980862 GSVIVG01014301001 2464855 2470707 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026028001 25604424 25604683 GSVIVG01004038001 14435817 14475953 GSVIVG01011484001 29974611 29983171 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01011484001 29974611 29983171 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01011484001 29974611 29983171 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01011484001 29974611 29983171 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01011484001 29974611 29983171 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein N-ubiquityl(n)lysine = AMP + diphosphate + protein N-ubiquityl(n+1)lysine, i.e. the ligation of ubiquitin moieties, via isopeptide bonds, to extend the length of the multiubiquitin chain attached to a substrate protein. IEA GO:0034450 ubiquitin-ubiquitin ligase activity GSVIVG01011484001 29974611 29983171 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein N-ubiquityl(n)lysine = AMP + diphosphate + protein N-ubiquityl(n+1)lysine, i.e. the ligation of ubiquitin moieties, via isopeptide bonds, to extend the length of the multiubiquitin chain attached to a substrate protein. IEA GO:0034450 ubiquitin-ubiquitin ligase activity GSVIVG01029597001 20942421 20945310 GSVIVG01000932001 22035762 22036085 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01000932001 22035762 22036085 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds. IEA GO:0015035 protein disulfide oxidoreductase activity GSVIVG01015467001 3968621 3971975 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GSVIVG01024248001 176233 181054 GSVIVG01035602001 2624577 2635776 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin. IEA GO:0004221 ubiquitin thiolesterase activity GSVIVG01014212001 1509614 1511168 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01014212001 1509614 1511168 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01014212001 1509614 1511168 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008994001 4130505 4130666 GSVIVG01027417001 16907655 16909858 GSVIVG01038680001 21043968 21050250 GSVIVG01010664001 15385324 15386478 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01010664001 15385324 15386478 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01010664001 15385324 15386478 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01010664001 15385324 15386478 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01010664001 15385324 15386478 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01010664001 15385324 15386478 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01010664001 15385324 15386478 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01010664001 15385324 15386478 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01010664001 15385324 15386478 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01010664001 15385324 15386478 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01034736001 8644831 8651072 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01004584001 39132633 39133388 GO:0006270 DNA-dependent DNA replication initiation The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action. IEA GO:0005727 extrachromosomal circular DNA Circular DNA structures that are not part of a chromosome. IEA Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and primer. IEA GO:0003887 DNA-directed DNA polymerase activity GSVIVG01006529001 42898116 42899092 GSVIVG01001455001 21137328 21138054 GSVIVG01028222001 4743351 4744272 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with manganese (Mn) ions. IEA GO:0030145 manganese ion binding GSVIVG01028222001 4743351 4744272 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Functions in the storage of nutritious substrates. IEA GO:0045735 nutrient reservoir activity GSVIVG01028222001 4743351 4744272 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01017812001 3639531 3657495 GSVIVG01018510001 14054354 14061535 GO:0019538 protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01007722001 9915829 9919405 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01009186001 5900268 5902139 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01017279001 6285866 6293560 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01030106001 9898090 9904524 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01030106001 9898090 9904524 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003902001 13390690 13395574 GSVIVG01012246001 237202 239435 GSVIVG01033370001 21152385 21153561 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025489001 378630 385391 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01025489001 378630 385391 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01018571001 13234735 13235301 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01018571001 13234735 13235301 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01008888001 3177010 3180121 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01029468001 22497103 22509645 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029468001 22497103 22509645 Catalysis of the transfer of a functional group from one position to another within a single molecule. IEA GO:0016866 intramolecular transferase activity GSVIVG01015246001 2087437 2091634 Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. IEA GO:0008171 O-methyltransferase activity GSVIVG01007832001 8595971 8603212 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005667 transcription factor complex A protein complex, distinct from RNA polymerase, that associates with DNA at promoters or at cis-acting regulatory sequences, by direct binding or by interaction with other DNA-binding polypeptides or complexes, and regulates transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01000716001 130205 136695 GO:0000162 tryptophan biosynthetic process The chemical reactions and pathways resulting in the formation of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; tryptophan is synthesized from chorismate via anthranilate. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000716001 130205 136695 GO:0006568 tryptophan metabolic process The chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000716001 130205 136695 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000716001 130205 136695 GO:0000162 tryptophan biosynthetic process The chemical reactions and pathways resulting in the formation of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; tryptophan is synthesized from chorismate via anthranilate. IEA Catalysis of the reaction: L-serine + 1-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H2O. IEA GO:0004834 tryptophan synthase activity GSVIVG01000716001 130205 136695 GO:0006568 tryptophan metabolic process The chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid. IEA Catalysis of the reaction: L-serine + 1-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H2O. IEA GO:0004834 tryptophan synthase activity GSVIVG01000716001 130205 136695 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: L-serine + 1-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H2O. IEA GO:0004834 tryptophan synthase activity GSVIVG01032983001 24814715 24817019 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01032983001 24814715 24817019 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01007804001 8845208 8853960 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01007804001 8845208 8853960 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01007804001 8845208 8853960 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01007804001 8845208 8853960 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01007804001 8845208 8853960 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01007804001 8845208 8853960 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01007804001 8845208 8853960 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01007804001 8845208 8853960 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01007804001 8845208 8853960 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01007804001 8845208 8853960 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01007804001 8845208 8853960 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01007804001 8845208 8853960 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01007804001 8845208 8853960 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01007804001 8845208 8853960 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01007804001 8845208 8853960 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01007804001 8845208 8853960 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01007804001 8845208 8853960 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01007804001 8845208 8853960 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01007804001 8845208 8853960 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01007804001 8845208 8853960 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01007804001 8845208 8853960 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01007804001 8845208 8853960 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01007804001 8845208 8853960 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01007804001 8845208 8853960 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01007804001 8845208 8853960 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01007804001 8845208 8853960 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01007804001 8845208 8853960 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01007804001 8845208 8853960 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01007804001 8845208 8853960 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01007804001 8845208 8853960 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01007804001 8845208 8853960 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01007804001 8845208 8853960 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01007804001 8845208 8853960 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01007804001 8845208 8853960 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01007804001 8845208 8853960 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01007804001 8845208 8853960 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01007804001 8845208 8853960 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01007804001 8845208 8853960 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01007804001 8845208 8853960 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01007804001 8845208 8853960 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01032471001 27732886 27737118 GSVIVG01036215001 8843879 8844450 GSVIVG01020196001 9198947 9199984 GSVIVG01025576001 13937463 13939487 GSVIVG01020533001 4735585 4738406 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016603001 2475909 2477365 GSVIVG01009029001 4399276 4405724 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01009029001 4399276 4405724 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01009029001 4399276 4405724 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01009029001 4399276 4405724 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01009029001 4399276 4405724 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01009029001 4399276 4405724 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01009029001 4399276 4405724 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01009029001 4399276 4405724 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01009029001 4399276 4405724 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01009029001 4399276 4405724 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01009029001 4399276 4405724 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01009029001 4399276 4405724 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01009029001 4399276 4405724 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01009029001 4399276 4405724 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01009029001 4399276 4405724 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01009029001 4399276 4405724 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01009029001 4399276 4405724 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01009029001 4399276 4405724 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019299001 1686899 1715987 GO:0008299 isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01009191001 5932952 5935352 GSVIVG01017761001 3203018 3217695 GO:0000154 rRNA modification The covalent alteration of one or more nucleotides within an rRNA molecule to produce an rRNA molecule with a sequence that differs from that coded genetically. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the dimethylation two adjacent A residues in the loop closing the 3'-terminal stem of the 18S rRNA, using S-adenosyl-L-methionine as a methyl donor. IEA GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity GSVIVG01017761001 3203018 3217695 GO:0000154 rRNA modification The covalent alteration of one or more nucleotides within an rRNA molecule to produce an rRNA molecule with a sequence that differs from that coded genetically. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01017761001 3203018 3217695 GO:0000154 rRNA modification The covalent alteration of one or more nucleotides within an rRNA molecule to produce an rRNA molecule with a sequence that differs from that coded genetically. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule. IEA GO:0008649 rRNA methyltransferase activity GSVIVG01010329001 19548426 19557950 GSVIVG01001343001 23779547 23779798 GSVIVG01024110001 993329 994100 GSVIVG01032226001 13296740 13298823 GO:0015976 carbon utilization A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbon sources and then activates genes to scavenge the last traces of the primary carbon source and to transport and metabolize alternative carbon sources such as carbon dioxide or carbonic acid. The utilization process begins when the cell or organism detects carbon levels, includes the activation of genes whose products detect, transport or metabolize carbon-containing substances, and ends when carbon is incorporated into the cell or organism's metabolism. IEA Catalysis of the reaction: H2CO3 = CO2 + H2O. IEA GO:0004089 carbonate dehydratase activity GSVIVG01032226001 13296740 13298823 GO:0015976 carbon utilization A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbon sources and then activates genes to scavenge the last traces of the primary carbon source and to transport and metabolize alternative carbon sources such as carbon dioxide or carbonic acid. The utilization process begins when the cell or organism detects carbon levels, includes the activation of genes whose products detect, transport or metabolize carbon-containing substances, and ends when carbon is incorporated into the cell or organism's metabolism. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01023686001 9273774 9276967 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01023686001 9273774 9276967 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000948001 22200553 22202463 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01034364001 17389429 17390276 GSVIVG01014614001 5728070 5728504 GSVIVG01025367001 1415112 1421599 GSVIVG01009590001 9699734 9701502 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01009590001 9699734 9701502 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01009590001 9699734 9701502 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01009590001 9699734 9701502 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01034540001 19680342 19687518 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01034540001 19680342 19687518 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01034540001 19680342 19687518 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01034540001 19680342 19687518 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01007633001 11014106 11015622 GSVIVG01026388001 15475180 15483214 GO:0006519 cellular amino acid and derivative metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026388001 15475180 15483214 GO:0019752 carboxylic acid metabolic process The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026388001 15475180 15483214 GO:0006519 cellular amino acid and derivative metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells. IEA Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. IEA GO:0016831 carboxy-lyase activity GSVIVG01026388001 15475180 15483214 GO:0019752 carboxylic acid metabolic process The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). IEA Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. IEA GO:0016831 carboxy-lyase activity GSVIVG01026388001 15475180 15483214 GO:0006519 cellular amino acid and derivative metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01026388001 15475180 15483214 GO:0019752 carboxylic acid metabolic process The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01022221001 17625868 17626559 GSVIVG01012641001 265196 267250 Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01029269001 17757935 17771563 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029269001 17757935 17771563 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029269001 17757935 17771563 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01029269001 17757935 17771563 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01029269001 17757935 17771563 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01029269001 17757935 17771563 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01029269001 17757935 17771563 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01029269001 17757935 17771563 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01020725001 2657686 2664687 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion. IEA GO:0004806 triglyceride lipase activity GSVIVG01024251001 212422 229833 GSVIVG01024136001 864608 864874 GSVIVG01018298001 11522542 11579100 GO:0006506 GPI anchor biosynthetic process The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol moiety is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate moiety, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage. IEA GO:0031227 intrinsic to endoplasmic reticulum membrane Located in the endoplasmic reticulum membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01037766001 7676337 7684445 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01037766001 7676337 7684445 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019919001 4454773 4457750 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01001822001 26097626 26100354 GSVIVG01031231001 1016606 1018456 GO:0001522 pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01031231001 1016606 1018456 GO:0009451 RNA modification The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01031231001 1016606 1018456 GO:0001522 pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs. IEA Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. IEA GO:0009982 pseudouridine synthase activity GSVIVG01031231001 1016606 1018456 GO:0009451 RNA modification The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. IEA Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. IEA GO:0009982 pseudouridine synthase activity GSVIVG01006592001 26932222 26932833 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01006592001 26932222 26932833 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01014275001 2252694 2257913 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01014275001 2252694 2257913 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end. IEA GO:0004527 exonuclease activity GSVIVG01006463001 26178737 26180893 Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01028621001 10943570 10966338 GSVIVG01035390001 945473 948330 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01008869001 2914955 2920741 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01015484001 4094051 4095808 GSVIVG01032015001 23532026 23553698 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032015001 23532026 23553698 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01032015001 23532026 23553698 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01020634001 3636135 3638544 Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. IEA GO:0008171 O-methyltransferase activity GSVIVG01014577001 5331070 5331677 GSVIVG01027277001 17257184 17257425 GSVIVG01022536001 4511116 4513205 GSVIVG01018818001 19619115 19622397 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01005162001 18865854 18866530 GSVIVG01031806001 4513960 4520767 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01031806001 4513960 4520767 GO:0006970 response to osmotic stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01031806001 4513960 4520767 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01031806001 4513960 4520767 GO:0006970 response to osmotic stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01031806001 4513960 4520767 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01031806001 4513960 4520767 GO:0006970 response to osmotic stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01031806001 4513960 4520767 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01031806001 4513960 4520767 GO:0006970 response to osmotic stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01031806001 4513960 4520767 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031806001 4513960 4520767 GO:0006970 response to osmotic stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031043001 21322952 21341075 GO:0005789 endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01031471001 18188178 18189948 GSVIVG01031732001 3890515 3891598 GSVIVG01008809001 2324025 2335526 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA GSVIVG01026559001 21857377 21863191 GSVIVG01010193001 17127121 17127644 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01010193001 17127121 17127644 Catalysis of the two-stage endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides with 2',3'-cyclic phosphate intermediates. IEA GO:0033897 ribonuclease T2 activity GSVIVG01032103001 22672831 22681925 Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor. IEA GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen GSVIVG01030585001 6916043 6917314 GSVIVG01025768001 12098602 12100842 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004185 serine-type carboxypeptidase activity GSVIVG01025925001 27186733 27197462 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025925001 27186733 27197462 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0010181 FMN binding GSVIVG01025925001 27186733 27197462 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01035453001 1376491 1381817 GO:0007031 peroxisome organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules. IEA GO:0005778 peroxisomal membrane The lipid bilayer surrounding a peroxisome. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035453001 1376491 1381817 GO:0007031 peroxisome organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules. IEA GO:0005778 peroxisomal membrane The lipid bilayer surrounding a peroxisome. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01019034001 17548460 17551794 GSVIVG01028229001 4784043 4793269 GSVIVG01018713001 10745465 10745539 GSVIVG01001974001 5929323 5931655 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. IEA GO:0003743 translation initiation factor activity GSVIVG01001974001 5929323 5931655 GO:0006413 translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. IEA Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. IEA GO:0003743 translation initiation factor activity GSVIVG01007650001 10852795 10853467 GSVIVG01000745001 335949 340047 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01000745001 335949 340047 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01034110001 15087815 15094354 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01014329001 2702488 2703384 GSVIVG01010912001 15810540 15811910 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01009983001 13055734 13072493 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01009983001 13055734 13072493 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01009983001 13055734 13072493 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01009983001 13055734 13072493 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009983001 13055734 13072493 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01009983001 13055734 13072493 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. IEA GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GSVIVG01034988001 694778 701765 GO:0001932 regulation of protein amino acid phosphorylation Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein. IEA GO:0005952 cAMP-dependent protein kinase complex An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01034988001 694778 701765 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005952 cAMP-dependent protein kinase complex An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01034988001 694778 701765 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005952 cAMP-dependent protein kinase complex An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01034988001 694778 701765 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005952 cAMP-dependent protein kinase complex An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01034988001 694778 701765 GO:0001932 regulation of protein amino acid phosphorylation Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein. IEA GO:0005952 cAMP-dependent protein kinase complex An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01034988001 694778 701765 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005952 cAMP-dependent protein kinase complex An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01034988001 694778 701765 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005952 cAMP-dependent protein kinase complex An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01034988001 694778 701765 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005952 cAMP-dependent protein kinase complex An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01034988001 694778 701765 GO:0001932 regulation of protein amino acid phosphorylation Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein. IEA GO:0005952 cAMP-dependent protein kinase complex An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01034988001 694778 701765 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005952 cAMP-dependent protein kinase complex An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01034988001 694778 701765 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005952 cAMP-dependent protein kinase complex An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01034988001 694778 701765 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005952 cAMP-dependent protein kinase complex An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01034988001 694778 701765 GO:0001932 regulation of protein amino acid phosphorylation Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein. IEA GO:0005952 cAMP-dependent protein kinase complex An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01034988001 694778 701765 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005952 cAMP-dependent protein kinase complex An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01034988001 694778 701765 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005952 cAMP-dependent protein kinase complex An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01034988001 694778 701765 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005952 cAMP-dependent protein kinase complex An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01034988001 694778 701765 GO:0001932 regulation of protein amino acid phosphorylation Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein. IEA GO:0005952 cAMP-dependent protein kinase complex An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034988001 694778 701765 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005952 cAMP-dependent protein kinase complex An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034988001 694778 701765 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005952 cAMP-dependent protein kinase complex An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034988001 694778 701765 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005952 cAMP-dependent protein kinase complex An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034988001 694778 701765 GO:0001932 regulation of protein amino acid phosphorylation Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein. IEA GO:0005952 cAMP-dependent protein kinase complex An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer. IEA Modulation of the activity of the enzyme cAMP-dependent protein kinase. IEA GO:0008603 cAMP-dependent protein kinase regulator activity GSVIVG01034988001 694778 701765 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005952 cAMP-dependent protein kinase complex An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer. IEA Modulation of the activity of the enzyme cAMP-dependent protein kinase. IEA GO:0008603 cAMP-dependent protein kinase regulator activity GSVIVG01034988001 694778 701765 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005952 cAMP-dependent protein kinase complex An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer. IEA Modulation of the activity of the enzyme cAMP-dependent protein kinase. IEA GO:0008603 cAMP-dependent protein kinase regulator activity GSVIVG01034988001 694778 701765 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005952 cAMP-dependent protein kinase complex An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer. IEA Modulation of the activity of the enzyme cAMP-dependent protein kinase. IEA GO:0008603 cAMP-dependent protein kinase regulator activity GSVIVG01005720001 21604280 21608970 GSVIVG01011242001 9995553 10005655 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: N-acetyl-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate. IEA GO:0004610 phosphoacetylglucosamine mutase activity GSVIVG01011242001 9995553 10005655 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the transfer of a phosphate group from one position to another within a single molecule. IEA GO:0016868 intramolecular transferase activity, phosphotransferases GSVIVG01036791001 22505327 22505756 GSVIVG01010506001 21183179 21183481 GSVIVG01038553001 21915589 21926695 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01038553001 21915589 21926695 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01038553001 21915589 21926695 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01009875001 12002966 12003280 GSVIVG01038321001 12819321 12830246 GSVIVG01027503001 16165482 16170176 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01027503001 16165482 16170176 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01016759001 1062510 1104469 GSVIVG01000781001 87943 91747 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01027268001 17350591 17352433 GSVIVG01008089001 5865995 5870051 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01008089001 5865995 5870051 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid. IEA GO:0008378 galactosyltransferase activity GSVIVG01034951001 388112 396826 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01034951001 388112 396826 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01025505001 257195 259488 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025505001 257195 259488 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008944001 3668328 3697476 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01008944001 3668328 3697476 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01032816001 525665 528037 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01032816001 525665 528037 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030600001 7056923 7062674 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01030600001 7056923 7062674 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01030600001 7056923 7062674 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01030600001 7056923 7062674 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01030600001 7056923 7062674 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01030600001 7056923 7062674 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01030600001 7056923 7062674 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01030600001 7056923 7062674 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01030600001 7056923 7062674 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01030600001 7056923 7062674 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01030600001 7056923 7062674 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01030600001 7056923 7062674 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01030600001 7056923 7062674 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01030600001 7056923 7062674 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01030600001 7056923 7062674 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01030600001 7056923 7062674 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01030600001 7056923 7062674 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01030600001 7056923 7062674 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01030600001 7056923 7062674 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01030600001 7056923 7062674 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01030600001 7056923 7062674 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01030600001 7056923 7062674 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01030600001 7056923 7062674 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01030600001 7056923 7062674 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01030600001 7056923 7062674 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01030600001 7056923 7062674 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01030600001 7056923 7062674 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01030600001 7056923 7062674 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01030600001 7056923 7062674 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01030600001 7056923 7062674 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01027903001 9208762 9219691 GO:0006413 translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01027903001 9208762 9219691 GO:0006413 translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. IEA GO:0003743 translation initiation factor activity GSVIVG01025607001 13649237 13653339 GSVIVG01000374001 306862 307305 GSVIVG01037710001 7139585 7146224 GSVIVG01013495001 1854538 1857343 GSVIVG01037647001 6524669 6542013 GSVIVG01000403001 7551239 7552800 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01022633001 13886725 13895243 GSVIVG01036994001 9146222 9147403 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036994001 9146222 9147403 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01036994001 9146222 9147403 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01001088001 22547029 22561957 GSVIVG01027289001 17103640 17103867 GSVIVG01022329001 18540755 18543956 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01022329001 18540755 18543956 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01022329001 18540755 18543956 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01022329001 18540755 18543956 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01022329001 18540755 18543956 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01022329001 18540755 18543956 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01022329001 18540755 18543956 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01022329001 18540755 18543956 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01022329001 18540755 18543956 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01022329001 18540755 18543956 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01022329001 18540755 18543956 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01022329001 18540755 18543956 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01022329001 18540755 18543956 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01022329001 18540755 18543956 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01022329001 18540755 18543956 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01022329001 18540755 18543956 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01036375001 4335148 4335997 Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01036375001 4335148 4335997 Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01034891001 16093377 16093805 GSVIVG01022436001 2998942 3022064 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01022436001 2998942 3022064 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01022436001 2998942 3022064 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022436001 2998942 3022064 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01004716001 15451523 15468805 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01006077001 41156969 41159690 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01006077001 41156969 41159690 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01006077001 41156969 41159690 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006077001 41156969 41159690 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006077001 41156969 41159690 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01006077001 41156969 41159690 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01030406001 5311067 5318476 GSVIVG01016238001 6060582 6087112 GSVIVG01010025001 13551373 13554376 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01006059001 23652082 23652267 GO:0006631 fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01006059001 23652082 23652267 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01006059001 23652082 23652267 GO:0006631 fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. IEA Catalysis of the reaction: stearoyl-[acyl-carrier protein] + reduced acceptor + O2 = oleoyl-[acyl-carrier protein] + acceptor + H2O. The enzyme requires ferredoxin. IEA GO:0045300 acyl-[acyl-carrier-protein] desaturase activity GSVIVG01006059001 23652082 23652267 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: stearoyl-[acyl-carrier protein] + reduced acceptor + O2 = oleoyl-[acyl-carrier protein] + acceptor + H2O. The enzyme requires ferredoxin. IEA GO:0045300 acyl-[acyl-carrier-protein] desaturase activity GSVIVG01006059001 23652082 23652267 GO:0006631 fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01006059001 23652082 23652267 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01011125001 1371950 1381169 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01011125001 1371950 1381169 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01011125001 1371950 1381169 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate, driving the unwinding of the DNA helix. IEA GO:0004003 ATP-dependent DNA helicase activity GSVIVG01011125001 1371950 1381169 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate, driving the unwinding of the DNA helix. IEA GO:0004003 ATP-dependent DNA helicase activity GSVIVG01011125001 1371950 1381169 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011125001 1371950 1381169 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011125001 1371950 1381169 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01011125001 1371950 1381169 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01011125001 1371950 1381169 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. IEA GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GSVIVG01011125001 1371950 1381169 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. IEA GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GSVIVG01016134001 19558105 19558875 GSVIVG01025111001 4335057 4346456 GSVIVG01017119001 4364715 4372123 GSVIVG01021753001 10553196 10557216 GSVIVG01021529001 6683036 6694049 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01021529001 6683036 6694049 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01021529001 6683036 6694049 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015934 large ribosomal subunit The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01002388001 34539494 34540808 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033379001 21086755 21090159 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01033379001 21086755 21090159 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033379001 21086755 21090159 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the reaction: ATP + pyruvate = ADP + phosphoenolpyruvate. IEA GO:0004743 pyruvate kinase activity GSVIVG01033379001 21086755 21090159 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Interacting selectively and non-covalently with potassium (K+) ions. IEA GO:0030955 potassium ion binding GSVIVG01013590001 21241969 21242220 GSVIVG01008169001 5144245 5149804 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01022401001 19705101 19718763 GO:0008202 steroid metabolic process The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. IEA GSVIVG01033066001 25498818 25499375 GSVIVG01014745001 9157796 9158177 GSVIVG01014540001 4962648 4967645 GO:0016481 negative regulation of transcription Any cellular process that stops, prevents or reduces the frequency, rate or extent of transcription. IEA Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0010181 FMN binding GSVIVG01014540001 4962648 4967645 GO:0016481 negative regulation of transcription Any cellular process that stops, prevents or reduces the frequency, rate or extent of transcription. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001716001 396899 449036 GSVIVG01034885001 15898547 15905025 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01000656001 20462915 20467491 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000656001 20462915 20467491 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000656001 20462915 20467491 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000656001 20462915 20467491 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019215001 3286414 3297057 GSVIVG01034291001 14120952 14144009 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01006636001 27197871 27198172 GSVIVG01016636001 2286610 2289011 GSVIVG01011024001 2128691 2137784 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01011024001 2128691 2137784 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01021100001 1455569 1459668 GSVIVG01019184001 3851090 3851134 GSVIVG01018816001 19631411 19632575 GSVIVG01034712001 8210643 8212031 GSVIVG01008495001 1342830 1345896 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008495001 1342830 1345896 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01008495001 1342830 1345896 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01008495001 1342830 1345896 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli. IEA GO:0004707 MAP kinase activity GSVIVG01008495001 1342830 1345896 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01008495001 1342830 1345896 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012872001 6396169 6397657 GSVIVG01035368001 814858 815244 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031927001 5454209 5461137 GSVIVG01031678001 20096188 20097943 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01015806001 17687126 17687902 GSVIVG01015060001 781537 784323 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: 3-alpha(S)-strictosidine = tryptamine + secologanin. IEA GO:0016844 strictosidine synthase activity GSVIVG01010990001 2388249 2393261 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01010990001 2388249 2393261 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01036425001 5014037 5014096 GSVIVG01024075001 1303982 1347184 GSVIVG01023609001 7958115 7977524 GSVIVG01035566001 2362223 2365439 GSVIVG01037076001 8082178 8086790 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004185 serine-type carboxypeptidase activity GSVIVG01004010001 14321842 14337797 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01004010001 14321842 14337797 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01004010001 14321842 14337797 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. IEA GO:0004563 beta-N-acetylhexosaminidase activity GSVIVG01004010001 14321842 14337797 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01030311001 9104945 9109335 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01030311001 9104945 9109335 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01012560001 3593746 3621284 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01024039001 1559956 1564835 GSVIVG01036445001 22022561 22023962 GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. IEA GO:0016853 isomerase activity GSVIVG01008364001 2870160 2871375 GSVIVG01034203001 14448327 14453142 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01034203001 14448327 14453142 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01038240001 24546023 24549492 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032953001 24569426 24570830 GSVIVG01012240001 284312 287530 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01012240001 284312 287530 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01012240001 284312 287530 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01012240001 284312 287530 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01012240001 284312 287530 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01012240001 284312 287530 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01031905001 5287561 5290476 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01001797001 3294177 3301663 GSVIVG01008677001 1145341 1156720 GSVIVG01010138001 16128794 16129261 GSVIVG01020311001 21549491 21566639 GSVIVG01026904001 19522490 19523977 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01037449001 13535686 13571827 GSVIVG01000237001 20328262 20394419 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01018415001 9386715 9394969 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01026894001 19596299 19598512 GSVIVG01016359001 4550134 4557877 GSVIVG01037017001 8864717 8881628 GSVIVG01030328001 8786927 8789783 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals. IEA GO:0008519 ammonium transmembrane transporter activity GSVIVG01030328001 8786927 8789783 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals. IEA GO:0008519 ammonium transmembrane transporter activity GSVIVG01017064001 3898176 3900032 GSVIVG01030547001 6628197 6632478 GSVIVG01001779001 3040284 3040571 GSVIVG01033834001 17357057 17361779 GO:0016226 iron-sulfur cluster assembly The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01033834001 17357057 17361779 GO:0016226 iron-sulfur cluster assembly The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01033294001 21760498 21762949 GO:0017004 cytochrome complex assembly The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01033294001 21760498 21762949 GO:0017004 cytochrome complex assembly The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033294001 21760498 21762949 GO:0017004 cytochrome complex assembly The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033294001 21760498 21762949 GO:0017004 cytochrome complex assembly The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01033294001 21760498 21762949 GO:0017004 cytochrome complex assembly The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01020384001 20288420 20290073 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01038276001 24891430 24891792 GSVIVG01014595001 5430841 5434734 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01014595001 5430841 5434734 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01014595001 5430841 5434734 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014595001 5430841 5434734 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014595001 5430841 5434734 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014595001 5430841 5434734 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014595001 5430841 5434734 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01014595001 5430841 5434734 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01014595001 5430841 5434734 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01014595001 5430841 5434734 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01036160001 19952794 19953066 GSVIVG01030322001 8891286 8895225 GSVIVG01007980001 6996560 7022145 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01007980001 6996560 7022145 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01018372001 10246568 10257898 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Enables the directed movement of acyl groups into, out of, within or between cells. IEA GO:0000036 acyl carrier activity GSVIVG01018372001 10246568 10257898 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. IEA GO:0048037 cofactor binding GSVIVG01006081001 41198813 41200839 GO:0009690 cytokinin metabolic process The chemical reactions and pathways involving cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01006081001 41198813 41200839 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01006081001 41198813 41200839 GO:0009690 cytokinin metabolic process The chemical reactions and pathways involving cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01006081001 41198813 41200839 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01006081001 41198813 41200839 GO:0009690 cytokinin metabolic process The chemical reactions and pathways involving cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators. IEA Catalysis of the reaction: N6-dimethylallyladenine + acceptor + H2O = adenine + 3-methylbut-2-enal + reduced electron acceptor. IEA GO:0019139 cytokinin dehydrogenase activity GSVIVG01006081001 41198813 41200839 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: N6-dimethylallyladenine + acceptor + H2O = adenine + 3-methylbut-2-enal + reduced electron acceptor. IEA GO:0019139 cytokinin dehydrogenase activity GSVIVG01006081001 41198813 41200839 GO:0009690 cytokinin metabolic process The chemical reactions and pathways involving cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01006081001 41198813 41200839 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01011886001 3309093 3310127 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA Catalysis of the reaction: isopentenyl diphosphate + tRNA = diphosphate + tRNA containing 6-isopentenyladenosine. IEA GO:0004811 tRNA isopentenyltransferase activity GSVIVG01011886001 3309093 3310127 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006115001 41755061 41757471 GO:0006278 RNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01006115001 41755061 41757471 GO:0006278 RNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. IEA Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time. IEA GO:0003964 RNA-directed DNA polymerase activity GSVIVG01014917001 11837502 11838712 Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01014917001 11837502 11838712 Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01010090001 15219019 15223294 GSVIVG01029775001 14508755 14511319 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01029775001 14508755 14511319 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01029775001 14508755 14511319 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01029775001 14508755 14511319 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01018130001 6821636 6835674 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018304001 11420731 11422098 GSVIVG01020818001 1608187 1610098 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009654 oxygen evolving complex A complex, composed of a cluster of manganese, calcium and chloride ions bound to extrinsic proteins, that catalyzes the splitting of water to O2 and 4 H+. In cyanobacteria there are five extrinsic proteins in OEC (PsbO, PsbP-like, PsbQ-like, PsbU and PsbV), while in plants there are only three (PsbO, PsbP and PsbQ). IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01020818001 1608187 1610098 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0019898 extrinsic to membrane Loosely bound to one surface of a membrane, but not integrated into the hydrophobic region. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01014185001 1322474 1323002 GSVIVG01029798001 14934986 14962613 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01029798001 14934986 14962613 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01029798001 14934986 14962613 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01029798001 14934986 14962613 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01029798001 14934986 14962613 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01029798001 14934986 14962613 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01029798001 14934986 14962613 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029798001 14934986 14962613 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029798001 14934986 14962613 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029798001 14934986 14962613 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029798001 14934986 14962613 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: (Ac)2-L-Lys-D-alanyl-D-alanine + H2O = (Ac)2-L-Lys-D-alanine + D-alanine. IEA GO:0009002 serine-type D-Ala-D-Ala carboxypeptidase activity GSVIVG01029798001 14934986 14962613 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the reaction: (Ac)2-L-Lys-D-alanyl-D-alanine + H2O = (Ac)2-L-Lys-D-alanine + D-alanine. IEA GO:0009002 serine-type D-Ala-D-Ala carboxypeptidase activity GSVIVG01026228001 14458409 14461746 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01026228001 14458409 14461746 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01026228001 14458409 14461746 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01026228001 14458409 14461746 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01024948001 5757473 5760369 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01024948001 5757473 5760369 GO:0016068 type I hypersensitivity An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells or basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01024948001 5757473 5760369 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01024948001 5757473 5760369 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01024948001 5757473 5760369 GO:0016068 type I hypersensitivity An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells or basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01024948001 5757473 5760369 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01006104001 41535524 41537428 GSVIVG01017919001 4673537 4694663 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01017919001 4673537 4694663 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. IEA GO:0004722 protein serine/threonine phosphatase activity GSVIVG01000469001 8266669 8268137 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01001494001 5148031 5150828 GSVIVG01010853001 23355077 23362508 GSVIVG01017720001 2897130 2900064 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01017720001 2897130 2900064 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01008424001 2230450 2232935 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01008424001 2230450 2232935 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01008424001 2230450 2232935 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01008424001 2230450 2232935 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01008424001 2230450 2232935 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01008424001 2230450 2232935 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01008664001 37072 39024 GSVIVG01009839001 11723026 11723485 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026491001 22756099 22766447 GSVIVG01028726001 19380323 19386092 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01028726001 19380323 19386092 The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01019640001 2138692 2140585 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01002648001 35590182 35596448 GSVIVG01009219001 6350901 6376307 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01009219001 6350901 6376307 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01025454001 734373 738635 GSVIVG01020081001 10588294 10591940 GSVIVG01016410001 4164505 4165364 GSVIVG01015403001 3304621 3323320 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01015403001 3304621 3323320 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01015403001 3304621 3323320 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012543001 1081004 1088392 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01012543001 1081004 1088392 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01033782001 17870596 17875122 GSVIVG01038619001 21439501 21441052 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01038619001 21439501 21441052 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01038619001 21439501 21441052 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01038619001 21439501 21441052 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01038619001 21439501 21441052 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01038619001 21439501 21441052 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01038619001 21439501 21441052 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01038619001 21439501 21441052 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01020588001 3987905 3990299 GO:0006519 cellular amino acid and derivative metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01020588001 3987905 3990299 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01020588001 3987905 3990299 GO:0006519 cellular amino acid and derivative metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells. IEA Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. IEA GO:0008483 transaminase activity GSVIVG01020588001 3987905 3990299 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. IEA GO:0008483 transaminase activity GSVIVG01020588001 3987905 3990299 GO:0006519 cellular amino acid and derivative metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells. IEA Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). IEA GO:0016769 transferase activity, transferring nitrogenous groups GSVIVG01020588001 3987905 3990299 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). IEA GO:0016769 transferase activity, transferring nitrogenous groups GSVIVG01020588001 3987905 3990299 GO:0006519 cellular amino acid and derivative metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells. IEA Catalysis of the reaction: S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + methylthioadenosine. IEA GO:0016847 1-aminocyclopropane-1-carboxylate synthase activity GSVIVG01020588001 3987905 3990299 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + methylthioadenosine. IEA GO:0016847 1-aminocyclopropane-1-carboxylate synthase activity GSVIVG01020588001 3987905 3990299 GO:0006519 cellular amino acid and derivative metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01020588001 3987905 3990299 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01036596001 18848920 18888210 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01036596001 18848920 18888210 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01036596001 18848920 18888210 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with a ribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to ribose. IEA GO:0032549 ribonucleoside binding GSVIVG01027193001 17141519 17143048 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01027193001 17141519 17143048 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01017013001 3450748 3456244 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01017013001 3450748 3456244 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01014504001 4583507 4596488 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014504001 4583507 4596488 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014504001 4583507 4596488 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014504001 4583507 4596488 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014504001 4583507 4596488 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014504001 4583507 4596488 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014504001 4583507 4596488 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014504001 4583507 4596488 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014504001 4583507 4596488 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01014504001 4583507 4596488 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01012219001 475548 481438 GSVIVG01023281001 20167300 20186477 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01022527001 4369825 4386396 GO:0016117 carotenoid biosynthetic process The chemical reactions and pathways resulting in the formation of carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail. IEA Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. IEA GO:0016853 isomerase activity GSVIVG01013265001 6039133 6077850 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01013265001 6039133 6077850 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01022318001 18439672 18441205 GSVIVG01005928001 22781110 22784322 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA GSVIVG01038184001 24162131 24163288 GSVIVG01012165001 901077 903566 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01012165001 901077 903566 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01012165001 901077 903566 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012165001 901077 903566 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012165001 901077 903566 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012165001 901077 903566 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012165001 901077 903566 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01012165001 901077 903566 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01009040001 4466930 4475029 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01009040001 4466930 4475029 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01023326001 19709957 19713050 GSVIVG01003643001 11529185 11532991 GSVIVG01036217001 8830988 8843256 GSVIVG01020511001 18129430 18130854 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01020511001 18129430 18130854 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01020511001 18129430 18130854 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01020511001 18129430 18130854 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014831001 10312758 10326282 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with transfer RNA. IEA GO:0000049 tRNA binding GSVIVG01014831001 10312758 10326282 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe). IEA GO:0004826 phenylalanine-tRNA ligase activity GSVIVG01014831001 10312758 10326282 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010555001 16685530 16695150 GSVIVG01018786001 19840838 19853733 GSVIVG01025010001 5305145 5311089 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025010001 5305145 5311089 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025010001 5305145 5311089 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025010001 5305145 5311089 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025010001 5305145 5311089 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025010001 5305145 5311089 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025010001 5305145 5311089 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01025010001 5305145 5311089 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01025010001 5305145 5311089 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01025010001 5305145 5311089 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025010001 5305145 5311089 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025010001 5305145 5311089 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025010001 5305145 5311089 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01025010001 5305145 5311089 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01025010001 5305145 5311089 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01024928001 5953889 5956831 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016932001 2678224 2678776 GSVIVG01029973001 2521919 2523796 The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01025348001 1647644 1654281 Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01032326001 15090569 15101629 GSVIVG01014543001 4988165 5006408 GSVIVG01016707001 511562 514452 GSVIVG01034518001 20019050 20019480 GSVIVG01026064001 25056445 25063766 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01024281001 512958 513281 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01024281001 512958 513281 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01024281001 512958 513281 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01024281001 512958 513281 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024281001 512958 513281 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01024281001 512958 513281 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01020415001 19813960 19816800 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020415001 19813960 19816800 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020415001 19813960 19816800 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020415001 19813960 19816800 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018020001 5521761 5528578 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01018020001 5521761 5528578 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01018020001 5521761 5528578 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01018020001 5521761 5528578 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031726001 3854897 3866036 GSVIVG01031111001 2076186 2077390 GSVIVG01016838001 1797677 1798825 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01030523001 6460391 6462875 GSVIVG01005452001 40280764 40281481 GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA GSVIVG01029211001 18496266 18519870 GSVIVG01038103001 23508602 23514920 GSVIVG01037138001 28739676 28739861 GSVIVG01013000001 10370627 10374009 GSVIVG01027537001 15927100 15935189 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01027537001 15927100 15935189 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027537001 15927100 15935189 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01019376001 125743 135172 Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters. IEA GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters GSVIVG01022774001 16402918 16404247 GSVIVG01003479001 10627950 10633170 GO:0009405 pathogenesis The set of specific processes that generate the ability of an organism to cause disease in another. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01003479001 10627950 10633170 GO:0009405 pathogenesis The set of specific processes that generate the ability of an organism to cause disease in another. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01019516001 1253052 1258570 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01036156001 20001869 20006704 GO:0016575 histone deacetylation The modification of histones by removal of acetyl groups. IEA Catalysis of the hydrolysis of acetyl groups from histones, proteins complexed to DNA in chromatin and chromosomes. IEA GO:0004407 histone deacetylase activity GSVIVG01036156001 20001869 20006704 GO:0016575 histone deacetylation The modification of histones by removal of acetyl groups. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01036560001 23470715 23473584 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate. IEA GO:0004629 phospholipase C activity GSVIVG01036560001 23470715 23473584 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. IEA GO:0008081 phosphoric diester hydrolase activity GSVIVG01020104001 10289971 10290132 GSVIVG01015456001 3825506 3837096 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01015456001 3825506 3837096 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015456001 3825506 3837096 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01015456001 3825506 3837096 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01008972001 3956774 3960560 GSVIVG01001032001 20450345 20450890 GSVIVG01031054001 21477906 21501706 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01031054001 21477906 21501706 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0010181 FMN binding GSVIVG01031054001 21477906 21501706 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01006340001 321066 322298 GSVIVG01032590001 28625464 28631666 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar. IEA GO:0008375 acetylglucosaminyltransferase activity GSVIVG01013859001 5421949 5437497 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01013859001 5421949 5437497 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01035623001 2766507 2771861 GSVIVG01036660001 19942349 19949262 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036660001 19942349 19949262 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024171001 615717 620606 GSVIVG01009930001 12488625 12490747 GSVIVG01001180001 1042077 1042821 GSVIVG01028974001 16976683 16977766 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01027563001 15541545 15564932 GSVIVG01035517001 1937940 1949481 GSVIVG01032534001 28150788 28151507 GSVIVG01019405001 377928 380101 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01037775001 7760186 7767468 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01037775001 7760186 7767468 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01038740001 255889 291094 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01038740001 255889 291094 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01038740001 255889 291094 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01038740001 255889 291094 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038740001 255889 291094 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038740001 255889 291094 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038740001 255889 291094 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01038740001 255889 291094 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01038740001 255889 291094 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01038740001 255889 291094 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01038740001 255889 291094 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01038740001 255889 291094 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01038740001 255889 291094 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01038740001 255889 291094 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01038740001 255889 291094 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01035643001 2926996 2934108 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01035643001 2926996 2934108 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01021256001 3054528 3064656 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021256001 3054528 3064656 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01018059001 5920946 5929612 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018059001 5920946 5929612 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018059001 5920946 5929612 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018059001 5920946 5929612 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018059001 5920946 5929612 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01018059001 5920946 5929612 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01018059001 5920946 5929612 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01018059001 5920946 5929612 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01018059001 5920946 5929612 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018059001 5920946 5929612 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018059001 5920946 5929612 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018059001 5920946 5929612 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018059001 5920946 5929612 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of calcium (Ca) ions from one side of a membrane to the other. IEA GO:0015085 calcium ion transmembrane transporter activity GSVIVG01018059001 5920946 5929612 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of calcium (Ca) ions from one side of a membrane to the other. IEA GO:0015085 calcium ion transmembrane transporter activity GSVIVG01018059001 5920946 5929612 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of calcium (Ca) ions from one side of a membrane to the other. IEA GO:0015085 calcium ion transmembrane transporter activity GSVIVG01018059001 5920946 5929612 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of calcium (Ca) ions from one side of a membrane to the other. IEA GO:0015085 calcium ion transmembrane transporter activity GSVIVG01018059001 5920946 5929612 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01018059001 5920946 5929612 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01018059001 5920946 5929612 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01018059001 5920946 5929612 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01018059001 5920946 5929612 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01018059001 5920946 5929612 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01018059001 5920946 5929612 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01018059001 5920946 5929612 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01004599001 39170825 39171339 GSVIVG01008829001 2521402 2542260 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01012784001 23328402 23333135 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01012784001 23328402 23333135 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01035538001 2125789 2133322 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01035538001 2125789 2133322 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01035538001 2125789 2133322 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033180 proton-transporting V-type ATPase, V1 domain A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01035538001 2125789 2133322 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01035538001 2125789 2133322 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01035538001 2125789 2133322 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033180 proton-transporting V-type ATPase, V1 domain A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01035538001 2125789 2133322 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01035538001 2125789 2133322 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01035538001 2125789 2133322 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0033180 proton-transporting V-type ATPase, V1 domain A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01035538001 2125789 2133322 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01035538001 2125789 2133322 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01035538001 2125789 2133322 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033180 proton-transporting V-type ATPase, V1 domain A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01035538001 2125789 2133322 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01035538001 2125789 2133322 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01035538001 2125789 2133322 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033180 proton-transporting V-type ATPase, V1 domain A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01035538001 2125789 2133322 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01035538001 2125789 2133322 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01035538001 2125789 2133322 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0033180 proton-transporting V-type ATPase, V1 domain A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01035538001 2125789 2133322 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01035538001 2125789 2133322 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01035538001 2125789 2133322 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033180 proton-transporting V-type ATPase, V1 domain A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01035538001 2125789 2133322 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01035538001 2125789 2133322 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01035538001 2125789 2133322 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033180 proton-transporting V-type ATPase, V1 domain A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01035538001 2125789 2133322 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01035538001 2125789 2133322 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01035538001 2125789 2133322 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0033180 proton-transporting V-type ATPase, V1 domain A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01035538001 2125789 2133322 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01035538001 2125789 2133322 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01035538001 2125789 2133322 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033180 proton-transporting V-type ATPase, V1 domain A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01035538001 2125789 2133322 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01035538001 2125789 2133322 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01035538001 2125789 2133322 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033180 proton-transporting V-type ATPase, V1 domain A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01035538001 2125789 2133322 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01035538001 2125789 2133322 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01035538001 2125789 2133322 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0033180 proton-transporting V-type ATPase, V1 domain A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01035538001 2125789 2133322 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01035538001 2125789 2133322 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01035538001 2125789 2133322 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033180 proton-transporting V-type ATPase, V1 domain A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01035538001 2125789 2133322 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01035538001 2125789 2133322 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01035538001 2125789 2133322 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033180 proton-transporting V-type ATPase, V1 domain A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01035538001 2125789 2133322 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01035538001 2125789 2133322 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01035538001 2125789 2133322 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0033180 proton-transporting V-type ATPase, V1 domain A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01037753001 7518931 7525059 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01037753001 7518931 7525059 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01037753001 7518931 7525059 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01037753001 7518931 7525059 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01037753001 7518931 7525059 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01037753001 7518931 7525059 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01037753001 7518931 7525059 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01037753001 7518931 7525059 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01025298001 2351352 2352149 GSVIVG01013398001 713319 722594 GSVIVG01015178001 1596864 1599916 GSVIVG01010667001 15371807 15372954 GSVIVG01036141001 20230158 20235759 GSVIVG01031717001 3769536 3782588 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031717001 3769536 3782588 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01031717001 3769536 3782588 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01026585001 21377336 21378232 GSVIVG01034373001 17242398 17277211 GO:0006479 protein amino acid methylation The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01034373001 17242398 17277211 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01034373001 17242398 17277211 GO:0006479 protein amino acid methylation The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a methyl group (CH3-) to a protein. IEA GO:0008276 protein methyltransferase activity GSVIVG01034373001 17242398 17277211 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a methyl group (CH3-) to a protein. IEA GO:0008276 protein methyltransferase activity GSVIVG01001349001 23858916 23863956 GSVIVG01035676001 3216168 3228200 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01021408001 5034695 5035291 GSVIVG01030985001 20274221 20274771 GO:0006869 lipid transport The directed movement of lipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GSVIVG01015815001 17818134 17820344 GSVIVG01033668001 18797396 18803712 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0000159 protein phosphatase type 2A complex A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit. IEA Modulation of the activity of the enzyme protein phosphatase type 2A. IEA GO:0008601 protein phosphatase type 2A regulator activity GSVIVG01017362001 7318081 7337103 GO:0006614 SRP-dependent cotranslational protein targeting to membrane The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. IEA GO:0048500 signal recognition particle A complex of protein and RNA which facilitates translocation of proteins across membranes. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01017362001 7318081 7337103 GO:0006614 SRP-dependent cotranslational protein targeting to membrane The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. IEA GO:0048500 signal recognition particle A complex of protein and RNA which facilitates translocation of proteins across membranes. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017362001 7318081 7337103 GO:0006614 SRP-dependent cotranslational protein targeting to membrane The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. IEA GO:0048500 signal recognition particle A complex of protein and RNA which facilitates translocation of proteins across membranes. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01017362001 7318081 7337103 GO:0006614 SRP-dependent cotranslational protein targeting to membrane The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. IEA GO:0048500 signal recognition particle A complex of protein and RNA which facilitates translocation of proteins across membranes. IEA Interacting selectively and non-covalently with 7S RNA, the RNA component of the signal recognition particle (SRP). IEA GO:0008312 7S RNA binding GSVIVG01017362001 7318081 7337103 GO:0006614 SRP-dependent cotranslational protein targeting to membrane The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. IEA GO:0048500 signal recognition particle A complex of protein and RNA which facilitates translocation of proteins across membranes. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01030606001 7124950 7126231 GSVIVG01017346001 6977196 6990839 GO:0000398 nuclear mRNA splicing, via spliceosome The joining together of exons from one or more primary transcripts of nuclear messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. IEA GO:0005681 spliceosomal complex Any of a series of ribonucleoprotein complexes that contain RNA and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the splicing of a messenger RNA primary transcript to excise an intron. IEA GSVIVG01012080001 1587042 1587956 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01012080001 1587042 1587956 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01023371001 19219778 19220009 GSVIVG01014358001 2975506 2977210 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01014358001 2975506 2977210 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01014358001 2975506 2977210 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01021171001 2144210 2151134 GSVIVG01002492001 35058387 35059447 GSVIVG01022059001 16282110 16283733 GSVIVG01008066001 6127856 6130717 GSVIVG01032388001 26880237 26886134 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01018853001 19231588 19238266 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018853001 19231588 19238266 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01018853001 19231588 19238266 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01018853001 19231588 19238266 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01015558001 4910846 4913182 GSVIVG01038754001 485168 490927 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the reaction: pectin + n H2O = n methanol + pectate. IEA GO:0030599 pectinesterase activity GSVIVG01020122001 10140472 10145698 GSVIVG01030206001 10442918 10444884 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01030206001 10442918 10444884 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01030206001 10442918 10444884 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01030206001 10442918 10444884 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01030206001 10442918 10444884 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01030206001 10442918 10444884 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01030206001 10442918 10444884 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030206001 10442918 10444884 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007428001 31776053 31789748 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01007428001 31776053 31789748 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01003477001 10613185 10619357 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003477001 10613185 10619357 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01003477001 10613185 10619357 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. IEA GO:0016791 phosphatase activity GSVIVG01033198001 9420387 9426072 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01030092001 9757559 9759328 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01027409001 16956853 16963951 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01027409001 16956853 16963951 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01027409001 16956853 16963951 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01027409001 16956853 16963951 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01027409001 16956853 16963951 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01027409001 16956853 16963951 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028839001 18222303 18224981 GSVIVG01031392001 19181375 19186300 GSVIVG01025429001 872223 880200 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01017897001 4471909 4478098 GO:0006465 signal peptide processing The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell. IEA GO:0005787 signal peptidase complex A protein complex that is located in the endoplasmic reticulum membrane and cleaves the signal sequence from precursor proteins following their transport out of the cytoplasmic space. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01017897001 4471909 4478098 GO:0006465 signal peptide processing The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01013223001 6597031 6597204 GSVIVG01016177001 7042382 7043164 GSVIVG01024937001 5890963 5900010 GO:0008202 steroid metabolic process The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. IEA GSVIVG01016916001 2533701 2539061 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01016916001 2533701 2539061 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01016916001 2533701 2539061 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01016916001 2533701 2539061 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016916001 2533701 2539061 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012933001 13773085 13795036 GSVIVG01023997001 1836020 1843230 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of a calcium ion by a voltage-gated channel. IEA GO:0005245 voltage-gated calcium channel activity GSVIVG01036279001 7588357 7589067 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01036279001 7588357 7589067 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01036279001 7588357 7589067 GO:0042742 defense response to bacterium Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01036279001 7588357 7589067 GO:0050832 defense response to fungus Reactions triggered in response to the presence of a fungus that act to protect the cell or organism. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01002374001 34446508 34447602 GSVIVG01019205001 3513645 3516260 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01019205001 3513645 3516260 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01019205001 3513645 3516260 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01019205001 3513645 3516260 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033004001 25007118 25009304 GSVIVG01016685001 360895 366498 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01015122001 1192128 1198924 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01015122001 1192128 1198924 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01026404001 15677780 15678625 GSVIVG01031902001 5264339 5268000 GSVIVG01020907001 17443713 17468487 GSVIVG01007760001 9345961 9349253 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01037889001 6668088 6688722 GSVIVG01022876001 18496542 18497315 GSVIVG01025109001 4348977 4350807 GSVIVG01021944001 5293868 5311280 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01021944001 5293868 5311280 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01021944001 5293868 5311280 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01021944001 5293868 5311280 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01021944001 5293868 5311280 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01021944001 5293868 5311280 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01021944001 5293868 5311280 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01021944001 5293868 5311280 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01021944001 5293868 5311280 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01021944001 5293868 5311280 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01021944001 5293868 5311280 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01021944001 5293868 5311280 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01021944001 5293868 5311280 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021944001 5293868 5311280 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021944001 5293868 5311280 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021944001 5293868 5311280 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01021944001 5293868 5311280 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01021944001 5293868 5311280 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01014606001 5561706 5563074 GSVIVG01032879001 23689669 23694625 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01032879001 23689669 23694625 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01032879001 23689669 23694625 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01032879001 23689669 23694625 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017162001 4871700 4873548 GSVIVG01035959001 6519206 6520061 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01016519001 3187345 3190256 GO:0006364 rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01016519001 3187345 3190256 GO:0031167 rRNA methylation The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01016519001 3187345 3190256 GO:0032259 methylation The process by which a methyl group is covalently attached to a molecule. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01016519001 3187345 3190256 GO:0006364 rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01016519001 3187345 3190256 GO:0031167 rRNA methylation The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01016519001 3187345 3190256 GO:0032259 methylation The process by which a methyl group is covalently attached to a molecule. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01016519001 3187345 3190256 GO:0006364 rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. IEA Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. IEA GO:0008173 RNA methyltransferase activity GSVIVG01016519001 3187345 3190256 GO:0031167 rRNA methylation The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule. IEA Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. IEA GO:0008173 RNA methyltransferase activity GSVIVG01016519001 3187345 3190256 GO:0032259 methylation The process by which a methyl group is covalently attached to a molecule. IEA Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. IEA GO:0008173 RNA methyltransferase activity GSVIVG01028605001 10531509 10546864 GSVIVG01022362001 18996454 19005864 GSVIVG01016383001 4328911 4335358 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GSVIVG01023991001 1891648 1896304 GSVIVG01028449001 7778658 7783902 GSVIVG01023962001 2122056 2122813 GSVIVG01034418001 16566870 16570119 GSVIVG01033160001 8653856 8658091 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01033160001 8653856 8658091 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01033160001 8653856 8658091 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01033160001 8653856 8658091 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01033160001 8653856 8658091 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01033160001 8653856 8658091 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01033160001 8653856 8658091 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033160001 8653856 8658091 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033160001 8653856 8658091 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033160001 8653856 8658091 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033160001 8653856 8658091 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033160001 8653856 8658091 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033160001 8653856 8658091 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033160001 8653856 8658091 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033160001 8653856 8658091 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033160001 8653856 8658091 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033160001 8653856 8658091 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033160001 8653856 8658091 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033160001 8653856 8658091 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01033160001 8653856 8658091 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01033160001 8653856 8658091 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01033160001 8653856 8658091 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01033160001 8653856 8658091 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01033160001 8653856 8658091 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01033417001 20867819 20877846 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01020109001 10268687 10268818 GSVIVG01038464001 9739486 9744665 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024384001 1891219 1900902 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024384001 1891219 1900902 GO:0009116 nucleoside metabolic process The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024384001 1891219 1900902 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with a thromboxane (TXA) to initiate a change in cell activity. IEA GO:0004960 thromboxane receptor activity GSVIVG01024384001 1891219 1900902 GO:0009116 nucleoside metabolic process The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with a thromboxane (TXA) to initiate a change in cell activity. IEA GO:0004960 thromboxane receptor activity GSVIVG01003633001 558010 558639 GSVIVG01015339001 2805662 2814138 Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal. IEA GO:0004462 lactoylglutathione lyase activity GSVIVG01015339001 2805662 2814138 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01009663001 10298371 10306754 Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01036566001 23527885 23532718 Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01000907001 21773087 21777218 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01024204001 310969 312061 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01015458001 3839795 3852969 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01003277001 14023001 14024665 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01007916001 7556257 7599691 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01007916001 7556257 7599691 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01007916001 7556257 7599691 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01007916001 7556257 7599691 Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. IEA GO:0004519 endonuclease activity GSVIVG01007916001 7556257 7599691 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034200001 14481743 14486542 GSVIVG01037299001 16267308 16267914 GSVIVG01035629001 2824572 2831160 GSVIVG01024302001 682441 687767 GO:0007154 cell communication Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01024302001 682441 687767 GO:0007154 cell communication Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. IEA Interacting selectively and non-covalently with any inositol-containing glycerophospholipid. Phosphatidylinositol (PtdIns) and its phosphorylated derivatives are collectively referred to as phosphoinositides (PIs). IEA GO:0035091 phosphoinositide binding GSVIVG01010390001 20078603 20081514 GSVIVG01023271001 20272583 20396000 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01023271001 20272583 20396000 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01023271001 20272583 20396000 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023271001 20272583 20396000 Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01021488001 6065539 6066175 GSVIVG01035569001 2385160 2387738 GSVIVG01000578001 6907733 6911179 GSVIVG01016850001 1949324 1954245 GSVIVG01032221001 13136649 13136864 GSVIVG01004519001 38995005 38996132 GSVIVG01033467001 20444752 20447601 GSVIVG01000576001 6925463 6929045 GSVIVG01023486001 11059282 11107905 GSVIVG01027076001 18144275 18149907 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027076001 18144275 18149907 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027076001 18144275 18149907 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01027076001 18144275 18149907 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01027076001 18144275 18149907 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01027076001 18144275 18149907 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01027076001 18144275 18149907 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01027076001 18144275 18149907 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01024265001 361320 363190 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01015868001 18644115 18645326 GSVIVG01017676001 2543551 2558096 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01017676001 2543551 2558096 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017676001 2543551 2558096 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01017676001 2543551 2558096 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01000150001 15670902 15674503 GSVIVG01016894001 2351955 2355387 GSVIVG01000930001 22030979 22031840 GSVIVG01024492001 3322510 3323712 GSVIVG01030940001 19428998 19432951 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01018234001 12773481 12774819 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01020830001 1444406 1450445 GSVIVG01038342001 13282119 13282699 GSVIVG01031207001 1175054 1176479 Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01024071001 1362167 1363697 GSVIVG01001470001 21357691 21358077 GSVIVG01033829001 17401850 17403120 GSVIVG01016620001 2378357 2380159 GSVIVG01019421001 520831 533824 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01013467001 227240 228213 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01020087001 10471860 10492671 GO:0009168 purine ribonucleoside monophosphate biosynthetic process The chemical reactions and pathways resulting in the formation of purine ribonucleoside monophosphate, a glycosamine consisting of a purine base linked to a ribose sugar esterified with phosphate on its glycose moiety. IEA Catalysis of the reaction: AMP + H2O = IMP + NH3. IEA GO:0003876 AMP deaminase activity GSVIVG01020087001 10471860 10492671 GO:0009168 purine ribonucleoside monophosphate biosynthetic process The chemical reactions and pathways resulting in the formation of purine ribonucleoside monophosphate, a glycosamine consisting of a purine base linked to a ribose sugar esterified with phosphate on its glycose moiety. IEA Catalysis of the removal of an amino group from a substrate, producing ammonia (NH3). IEA GO:0019239 deaminase activity GSVIVG01008747001 1684391 1687018 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01008747001 1684391 1687018 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01008747001 1684391 1687018 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01008747001 1684391 1687018 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023902001 2581957 2585281 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01023902001 2581957 2585281 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01009353001 7627110 7628513 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01009353001 7627110 7628513 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01009353001 7627110 7628513 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01009353001 7627110 7628513 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01035351001 690536 694940 GO:0006783 heme biosynthetic process The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors. IEA Catalysis of the reaction: protoporphyrin + Fe2+ = protoheme + 2 H+. IEA GO:0004325 ferrochelatase activity GSVIVG01014161001 955252 960645 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01014161001 955252 960645 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01014161001 955252 960645 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014161001 955252 960645 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014161001 955252 960645 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014161001 955252 960645 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014161001 955252 960645 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01014161001 955252 960645 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01024791001 6917578 6931952 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01024791001 6917578 6931952 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01024791001 6917578 6931952 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01024791001 6917578 6931952 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01024791001 6917578 6931952 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01024791001 6917578 6931952 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01024791001 6917578 6931952 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024791001 6917578 6931952 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024791001 6917578 6931952 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024791001 6917578 6931952 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01024791001 6917578 6931952 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01024791001 6917578 6931952 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01024791001 6917578 6931952 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01024791001 6917578 6931952 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01024791001 6917578 6931952 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01007802001 8880242 8883008 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01028205001 4612041 4615672 GO:0006730 one-carbon metabolic process The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. IEA Catalysis of the reaction: ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine. IEA GO:0004478 methionine adenosyltransferase activity GSVIVG01028205001 4612041 4615672 GO:0006730 one-carbon metabolic process The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024883001 6253079 6253862 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024883001 6253079 6253862 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024883001 6253079 6253862 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024883001 6253079 6253862 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024883001 6253079 6253862 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024883001 6253079 6253862 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024883001 6253079 6253862 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01024883001 6253079 6253862 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01024883001 6253079 6253862 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01024883001 6253079 6253862 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024883001 6253079 6253862 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024883001 6253079 6253862 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01015105001 1092060 1092498 Interacting selectively and non-covalently with acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group. IEA GO:0000062 acyl-CoA binding GSVIVG01015105001 1092060 1092498 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008019001 6634544 6638502 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008019001 6634544 6638502 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01008246001 4155405 4159947 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01008246001 4155405 4159947 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01017223001 5612907 5616659 GO:0006820 anion transport The directed movement of anions, atoms or small molecules with a net negative charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA IEA GO:0005452 inorganic anion exchanger activity GSVIVG01017223001 5612907 5616659 GO:0006820 anion transport The directed movement of anions, atoms or small molecules with a net negative charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA IEA GO:0005452 inorganic anion exchanger activity GSVIVG01017223001 5612907 5616659 GO:0006820 anion transport The directed movement of anions, atoms or small molecules with a net negative charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA IEA GO:0015380 anion exchanger activity GSVIVG01017223001 5612907 5616659 GO:0006820 anion transport The directed movement of anions, atoms or small molecules with a net negative charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA IEA GO:0015380 anion exchanger activity GSVIVG01022551001 4826460 4827293 GSVIVG01005243001 19798442 19802434 GSVIVG01000492001 14902433 14920509 GSVIVG01010307001 19241665 19244752 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01010307001 19241665 19244752 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01010307001 19241665 19244752 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01010307001 19241665 19244752 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01028453001 7804401 7806200 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01028453001 7804401 7806200 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01028382001 6850176 6869742 GSVIVG01034509001 20159285 20168711 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c The transfer of electrons from ubiquinol to cytochrome c that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex III. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+. IEA GO:0008121 ubiquinol-cytochrome-c reductase activity GSVIVG01015466001 3966549 3968498 GSVIVG01018932001 18557138 18557335 GSVIVG01012141001 1086665 1093073 GO:0006829 zinc ion transport The directed movement of zinc (Zn) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. IEA GO:0005385 zinc ion transmembrane transporter activity GSVIVG01012141001 1086665 1093073 GO:0006829 zinc ion transport The directed movement of zinc (Zn) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. IEA GO:0005385 zinc ion transmembrane transporter activity GSVIVG01012141001 1086665 1093073 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. IEA GO:0005385 zinc ion transmembrane transporter activity GSVIVG01012141001 1086665 1093073 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. IEA GO:0005385 zinc ion transmembrane transporter activity GSVIVG01012141001 1086665 1093073 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. IEA GO:0005385 zinc ion transmembrane transporter activity GSVIVG01012141001 1086665 1093073 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. IEA GO:0005385 zinc ion transmembrane transporter activity GSVIVG01012141001 1086665 1093073 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. IEA GO:0005385 zinc ion transmembrane transporter activity GSVIVG01012141001 1086665 1093073 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. IEA GO:0005385 zinc ion transmembrane transporter activity GSVIVG01012141001 1086665 1093073 GO:0006829 zinc ion transport The directed movement of zinc (Zn) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01012141001 1086665 1093073 GO:0006829 zinc ion transport The directed movement of zinc (Zn) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01012141001 1086665 1093073 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01012141001 1086665 1093073 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01012141001 1086665 1093073 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01012141001 1086665 1093073 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01012141001 1086665 1093073 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01012141001 1086665 1093073 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01012141001 1086665 1093073 GO:0006829 zinc ion transport The directed movement of zinc (Zn) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01012141001 1086665 1093073 GO:0006829 zinc ion transport The directed movement of zinc (Zn) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01012141001 1086665 1093073 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01012141001 1086665 1093073 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01012141001 1086665 1093073 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01012141001 1086665 1093073 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01012141001 1086665 1093073 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01012141001 1086665 1093073 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01007564001 11978867 11993275 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01007564001 11978867 11993275 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01033534001 19947751 19948621 GSVIVG01015390001 3234845 3236286 GSVIVG01024154001 714369 721528 GO:0006364 rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. IEA GSVIVG01019967001 12222018 12223982 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01027908001 9246936 9248358 GSVIVG01013541001 20435027 20435134 GSVIVG01019746001 2915652 2921109 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019746001 2915652 2921109 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01017593001 11098018 11101198 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01017593001 11098018 11101198 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01017593001 11098018 11101198 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01017593001 11098018 11101198 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01007882001 7980105 7980632 GSVIVG01028088001 3712304 3714210 GSVIVG01008793001 2130880 2138950 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01029573001 21395927 21400592 Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0010181 FMN binding GSVIVG01019439001 685300 688031 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01019439001 685300 688031 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01019439001 685300 688031 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with 5S ribosomal RNA, the smallest RNA constituent of a ribosome. IEA GO:0008097 5S rRNA binding GSVIVG01019439001 685300 688031 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with 5S ribosomal RNA, the smallest RNA constituent of a ribosome. IEA GO:0008097 5S rRNA binding GSVIVG01020281001 21920857 21934724 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020281001 21920857 21934724 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01020281001 21920857 21934724 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). IEA GO:0003755 peptidyl-prolyl cis-trans isomerase activity GSVIVG01020281001 21920857 21934724 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01038610001 21519347 21527110 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01038610001 21519347 21527110 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01038610001 21519347 21527110 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01038610001 21519347 21527110 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038610001 21519347 21527110 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01038610001 21519347 21527110 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01014734001 9068111 9071818 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01013512001 2018743 2027660 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01013512001 2018743 2027660 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01013512001 2018743 2027660 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013512001 2018743 2027660 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013512001 2018743 2027660 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013512001 2018743 2027660 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013512001 2018743 2027660 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01013512001 2018743 2027660 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01004021001 1401232 1404140 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01004021001 1401232 1404140 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01004021001 1401232 1404140 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01004021001 1401232 1404140 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01004021001 1401232 1404140 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01004021001 1401232 1404140 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01004021001 1401232 1404140 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01004021001 1401232 1404140 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01037847001 7168721 7177148 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01037847001 7168721 7177148 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01034691001 7811427 7817649 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01034691001 7811427 7817649 Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01034691001 7811427 7817649 Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01027608001 15085257 15090948 GO:0009072 aromatic amino acid family metabolic process The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035428001 1222048 1224025 GSVIVG01000357001 12160726 12163148 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01000357001 12160726 12163148 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031819001 4676350 4690973 GSVIVG01015119001 1166964 1173399 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: phosphatidylcholine + a sterol = a sterol ester + 1-acylglycerophosphocholine. IEA GO:0004607 phosphatidylcholine-sterol O-acyltransferase activity GSVIVG01009106001 5092140 5102291 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01009106001 5092140 5102291 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01009106001 5092140 5102291 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01009106001 5092140 5102291 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01009106001 5092140 5102291 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01009106001 5092140 5102291 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01009106001 5092140 5102291 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01009106001 5092140 5102291 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01009106001 5092140 5102291 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01009106001 5092140 5102291 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01022067001 16322549 16324116 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01022067001 16322549 16324116 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01029640001 20294857 20299058 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025158001 3888767 3899160 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor. IEA GO:0003995 acyl-CoA dehydrogenase activity GSVIVG01025158001 3888767 3899160 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor. IEA GO:0003995 acyl-CoA dehydrogenase activity GSVIVG01025158001 3888767 3899160 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025158001 3888767 3899160 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025158001 3888767 3899160 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GSVIVG01025158001 3888767 3899160 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GSVIVG01025158001 3888767 3899160 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01025158001 3888767 3899160 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01033022001 25123316 25126605 GSVIVG01034717001 8324472 8327622 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01034717001 8324472 8327622 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01034717001 8324472 8327622 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01034717001 8324472 8327622 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01034717001 8324472 8327622 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the movement of phospholipids from one membrane face to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP. IEA GO:0004012 phospholipid-translocating ATPase activity GSVIVG01034717001 8324472 8327622 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the movement of phospholipids from one membrane face to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP. IEA GO:0004012 phospholipid-translocating ATPase activity GSVIVG01034717001 8324472 8327622 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the movement of phospholipids from one membrane face to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP. IEA GO:0004012 phospholipid-translocating ATPase activity GSVIVG01034717001 8324472 8327622 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the movement of phospholipids from one membrane face to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP. IEA GO:0004012 phospholipid-translocating ATPase activity GSVIVG01034717001 8324472 8327622 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034717001 8324472 8327622 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034717001 8324472 8327622 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034717001 8324472 8327622 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034717001 8324472 8327622 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01034717001 8324472 8327622 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01034717001 8324472 8327622 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01034717001 8324472 8327622 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01034717001 8324472 8327622 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01034717001 8324472 8327622 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01034717001 8324472 8327622 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01034717001 8324472 8327622 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01015383001 3163807 3169618 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01015383001 3163807 3169618 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01015383001 3163807 3169618 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01015383001 3163807 3169618 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. IEA GO:0005179 hormone activity GSVIVG01015383001 3163807 3169618 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006316001 24846234 24858144 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01006316001 24846234 24858144 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01006316001 24846234 24858144 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01006316001 24846234 24858144 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01006316001 24846234 24858144 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01006316001 24846234 24858144 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01006316001 24846234 24858144 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006316001 24846234 24858144 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015488001 4126320 4146088 GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01011574001 6319499 6325465 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01004710001 15419142 15420605 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01004710001 15419142 15420605 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01032418001 27184080 27213170 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008282001 3670796 3671231 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01014013001 8946108 8946754 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GSVIVG01008762001 1778795 1780353 GO:0009664 plant-type cell wall organization A process that results in the assembly and arrangement of constituent parts of the cellulose and pectin-containing cell wall, or in the disassembly of the cellulose and pectin-containing cell wall. This process is carried out at the cellular level. An example of this process is found in Arabidopsis thaliana. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA GSVIVG01008183001 4931761 4931943 GSVIVG01037488001 12830288 12839311 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01029913001 1389043 1394040 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01029913001 1389043 1394040 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01029913001 1389043 1394040 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01029913001 1389043 1394040 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01029057001 11589343 11591070 GSVIVG01013918001 6743260 6744066 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01013918001 6743260 6744066 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01008836001 2618399 2626185 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0005839 proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. IEA GO:0004175 endopeptidase activity GSVIVG01008836001 2618399 2626185 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0005839 proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. IEA Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. IEA GO:0004298 threonine-type endopeptidase activity GSVIVG01025256001 2656231 2658769 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025256001 2656231 2658769 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01031457001 18321161 18327220 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01031457001 18321161 18327220 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01031457001 18321161 18327220 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of hydroxylation at the 7-methyl group of chlorophyllide a, according to the reactions: chlorophyllide a + O2 + NADPH + H+ = 7-hydroxychlorophyllide a + H2O + NADP+ and 7-hydroxychlorophyllide a + O2 + NADPH + H+ = chlorophyllide b + 2 H2O + NADP+. IEA GO:0010277 chlorophyllide a oxygenase activity GSVIVG01031457001 18321161 18327220 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Catalysis of hydroxylation at the 7-methyl group of chlorophyllide a, according to the reactions: chlorophyllide a + O2 + NADPH + H+ = 7-hydroxychlorophyllide a + H2O + NADP+ and 7-hydroxychlorophyllide a + O2 + NADPH + H+ = chlorophyllide b + 2 H2O + NADP+. IEA GO:0010277 chlorophyllide a oxygenase activity GSVIVG01031457001 18321161 18327220 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031457001 18321161 18327220 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031457001 18321161 18327220 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01031457001 18321161 18327220 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01031457001 18321161 18327220 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01031457001 18321161 18327220 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01031457001 18321161 18327220 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051537 2 iron, 2 sulfur cluster binding GSVIVG01031457001 18321161 18327220 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051537 2 iron, 2 sulfur cluster binding GSVIVG01011934001 2899462 2906370 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01014904001 11542533 11543663 Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01014904001 11542533 11543663 Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01014904001 11542533 11543663 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01014904001 11542533 11543663 Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01006386001 25540314 25540807 GSVIVG01016731001 717966 724893 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0000502 proteasome complex A large multisubunit complex which catalyzes protein degradation. This complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. IEA GO:0004175 endopeptidase activity GSVIVG01016731001 717966 724893 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005839 proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. IEA GO:0004175 endopeptidase activity GSVIVG01016731001 717966 724893 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0019773 proteasome core complex, alpha-subunit complex The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. IEA GO:0004175 endopeptidase activity GSVIVG01016731001 717966 724893 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0000502 proteasome complex A large multisubunit complex which catalyzes protein degradation. This complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. IEA GO:0004175 endopeptidase activity GSVIVG01016731001 717966 724893 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0005839 proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. IEA GO:0004175 endopeptidase activity GSVIVG01016731001 717966 724893 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0019773 proteasome core complex, alpha-subunit complex The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. IEA GO:0004175 endopeptidase activity GSVIVG01016731001 717966 724893 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0000502 proteasome complex A large multisubunit complex which catalyzes protein degradation. This complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core. IEA Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. IEA GO:0004298 threonine-type endopeptidase activity GSVIVG01016731001 717966 724893 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005839 proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. IEA Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. IEA GO:0004298 threonine-type endopeptidase activity GSVIVG01016731001 717966 724893 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0019773 proteasome core complex, alpha-subunit complex The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. IEA GO:0004298 threonine-type endopeptidase activity GSVIVG01016731001 717966 724893 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0000502 proteasome complex A large multisubunit complex which catalyzes protein degradation. This complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core. IEA Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. IEA GO:0004298 threonine-type endopeptidase activity GSVIVG01016731001 717966 724893 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0005839 proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. IEA Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. IEA GO:0004298 threonine-type endopeptidase activity GSVIVG01016731001 717966 724893 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0019773 proteasome core complex, alpha-subunit complex The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. IEA GO:0004298 threonine-type endopeptidase activity GSVIVG01016731001 717966 724893 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0000502 proteasome complex A large multisubunit complex which catalyzes protein degradation. This complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01016731001 717966 724893 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005839 proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01016731001 717966 724893 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0019773 proteasome core complex, alpha-subunit complex The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01016731001 717966 724893 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0000502 proteasome complex A large multisubunit complex which catalyzes protein degradation. This complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01016731001 717966 724893 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0005839 proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01016731001 717966 724893 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0019773 proteasome core complex, alpha-subunit complex The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01016731001 717966 724893 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0000502 proteasome complex A large multisubunit complex which catalyzes protein degradation. This complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01016731001 717966 724893 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005839 proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01016731001 717966 724893 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0019773 proteasome core complex, alpha-subunit complex The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01016731001 717966 724893 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0000502 proteasome complex A large multisubunit complex which catalyzes protein degradation. This complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01016731001 717966 724893 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0005839 proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01016731001 717966 724893 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0019773 proteasome core complex, alpha-subunit complex The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01037780001 7803504 7814106 GSVIVG01010475001 20910081 20913536 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01010475001 20910081 20913536 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01010475001 20910081 20913536 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01010475001 20910081 20913536 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01012887001 6533767 6535235 GSVIVG01009863001 11909685 11914852 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) All non-F1 subunits of the mitochondrial hydrogen-transporting ATP synthase, including integral and peripheral mitochondrial inner membrane proteins. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01031810001 4623403 4627530 GSVIVG01003354001 9279224 9289282 Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01003354001 9279224 9289282 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01008473001 1582167 1627116 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01008473001 1582167 1627116 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01008473001 1582167 1627116 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01008473001 1582167 1627116 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017797001 3554059 3555764 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01017797001 3554059 3555764 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016624001 2363430 2364537 GSVIVG01038633001 21322701 21327801 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01038633001 21322701 21327801 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01034134001 14916670 14922764 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01034134001 14916670 14922764 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01003733001 7480314 7485516 GSVIVG01011639001 5672820 5681127 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01037461001 13321997 13323136 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01031477001 18138124 18144706 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031477001 18138124 18144706 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031477001 18138124 18144706 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031477001 18138124 18144706 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031477001 18138124 18144706 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031477001 18138124 18144706 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031477001 18138124 18144706 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01031477001 18138124 18144706 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01031477001 18138124 18144706 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01031477001 18138124 18144706 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031477001 18138124 18144706 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031477001 18138124 18144706 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031982001 5902159 5903523 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01014295001 2384274 2391999 GO:0006479 protein amino acid methylation The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a methyl group (CH3-) to a protein. IEA GO:0008276 protein methyltransferase activity GSVIVG01000139001 15580298 15581836 GSVIVG01025450001 754537 758838 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001432001 20936330 20938144 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01001432001 20936330 20938144 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01001432001 20936330 20938144 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with ribosomal RNA. IEA GO:0019843 rRNA binding GSVIVG01001432001 20936330 20938144 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Interacting selectively and non-covalently with ribosomal RNA. IEA GO:0019843 rRNA binding GSVIVG01008646001 157789 167943 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01008646001 157789 167943 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01034779001 21278127 21332628 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01034779001 21278127 21332628 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01034779001 21278127 21332628 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01034779001 21278127 21332628 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034779001 21278127 21332628 Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01034779001 21278127 21332628 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01022516001 4260110 4262083 GSVIVG01019063001 17203388 17213431 GSVIVG01011669001 5369377 5373087 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01009697001 10554977 10581855 GO:0006094 gluconeogenesis The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. IEA Catalysis of the reaction: D-glucose 6-phosphate = D-fructose 6-phosphate. IEA GO:0004347 glucose-6-phosphate isomerase activity GSVIVG01009697001 10554977 10581855 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the reaction: D-glucose 6-phosphate = D-fructose 6-phosphate. IEA GO:0004347 glucose-6-phosphate isomerase activity GSVIVG01019707001 2585171 2615383 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032693001 1467798 1469392 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01032693001 1467798 1469392 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01032693001 1467798 1469392 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01032693001 1467798 1469392 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01035705001 3478070 3480238 GSVIVG01019489001 1053713 1055575 GSVIVG01013067001 8806501 8811165 GSVIVG01030425001 5464697 5472560 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01030425001 5464697 5472560 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end. IEA GO:0008408 3'-5' exonuclease activity GSVIVG01020760001 2305899 2308708 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01020760001 2305899 2308708 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019591001 1804245 1812371 GSVIVG01037106001 29102287 29103639 GSVIVG01034952001 397744 400384 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01034952001 397744 400384 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with ribosomal RNA. IEA GO:0019843 rRNA binding GSVIVG01007735001 9731585 9760223 GO:0015937 coenzyme A biosynthetic process The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. IEA Catalysis of the reaction: ATP + pantothenate = ADP + D-4'-phosphopantothenate. IEA GO:0004594 pantothenate kinase activity GSVIVG01007735001 9731585 9760223 GO:0015937 coenzyme A biosynthetic process The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006538001 43033858 43035738 GSVIVG01035926001 6021156 6034187 GSVIVG01006768001 28286374 28289728 GSVIVG01000754001 391735 396351 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01000754001 391735 396351 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01000754001 391735 396351 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015935 small ribosomal subunit The smaller of the two subunits of a ribosome. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01000754001 391735 396351 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01000754001 391735 396351 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01000754001 391735 396351 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015935 small ribosomal subunit The smaller of the two subunits of a ribosome. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01031380001 19331347 19339760 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01031380001 19331347 19339760 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01031380001 19331347 19339760 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031380001 19331347 19339760 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01031380001 19331347 19339760 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01031380001 19331347 19339760 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate. IEA GO:0019001 guanyl nucleotide binding GSVIVG01030520001 6429979 6431952 GSVIVG01027314001 16765770 16825044 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01027314001 16765770 16825044 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01027314001 16765770 16825044 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA. IEA GO:0003916 DNA topoisomerase activity GSVIVG01027314001 16765770 16825044 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA. IEA GO:0003916 DNA topoisomerase activity GSVIVG01027314001 16765770 16825044 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. IEA GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity GSVIVG01027314001 16765770 16825044 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. IEA GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity GSVIVG01027314001 16765770 16825044 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027314001 16765770 16825044 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023949001 2231719 2242474 GO:0006099 tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01023949001 2231719 2242474 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01023949001 2231719 2242474 GO:0006099 tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of the reaction: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH + H+. IEA GO:0004449 isocitrate dehydrogenase (NAD+) activity GSVIVG01023949001 2231719 2242474 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of the reaction: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH + H+. IEA GO:0004449 isocitrate dehydrogenase (NAD+) activity GSVIVG01023949001 2231719 2242474 GO:0006099 tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01023949001 2231719 2242474 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01023949001 2231719 2242474 GO:0006099 tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01023949001 2231719 2242474 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01003543001 241554 241802 GSVIVG01027972001 2908223 2914965 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01038520001 10920625 10933095 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01038520001 10920625 10933095 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and primer. IEA GO:0003887 DNA-directed DNA polymerase activity GSVIVG01038520001 10920625 10933095 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026607001 21096321 21098453 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01035638001 2889371 2892149 GSVIVG01001903001 7010638 7046286 GSVIVG01036237001 8305341 8321747 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01005755001 21850606 21857653 GSVIVG01000593001 6727675 6732296 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids. IEA GO:0004518 nuclease activity GSVIVG01004065001 664954 665712 GSVIVG01028542001 9482476 9486270 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01028542001 9482476 9486270 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01028542001 9482476 9486270 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01028542001 9482476 9486270 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01028542001 9482476 9486270 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022613001 13406894 13407178 GSVIVG01033049001 25325845 25334371 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030143001 10215100 10237447 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01030143001 10215100 10237447 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01030143001 10215100 10237447 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01030143001 10215100 10237447 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01030143001 10215100 10237447 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01030143001 10215100 10237447 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01007599001 11411378 11418477 GSVIVG01034372001 17284723 17286494 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01019151001 16084015 16085284 GO:0007047 cellular cell wall organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA Catalysis of the reaction: UDP-glucose + glycogenin = UDP + glucosylglycogenin. IEA GO:0008466 glycogenin glucosyltransferase activity GSVIVG01019151001 16084015 16085284 GO:0007047 cellular cell wall organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. IEA GO:0009505 plant-type cell wall A more or less rigid stucture lying outside the cell membrane of a cell and composed of cellulose and pectin and other organic and inorganic substances. IEA Catalysis of the reaction: UDP-glucose + glycogenin = UDP + glucosylglycogenin. IEA GO:0008466 glycogenin glucosyltransferase activity GSVIVG01019151001 16084015 16085284 GO:0007047 cellular cell wall organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. IEA GO:0030054 cell junction A plasma membrane part that forms a specialized region of connection between two cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix. IEA Catalysis of the reaction: UDP-glucose + glycogenin = UDP + glucosylglycogenin. IEA GO:0008466 glycogenin glucosyltransferase activity GSVIVG01019151001 16084015 16085284 GO:0030244 cellulose biosynthetic process The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA Catalysis of the reaction: UDP-glucose + glycogenin = UDP + glucosylglycogenin. IEA GO:0008466 glycogenin glucosyltransferase activity GSVIVG01019151001 16084015 16085284 GO:0030244 cellulose biosynthetic process The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation. IEA GO:0009505 plant-type cell wall A more or less rigid stucture lying outside the cell membrane of a cell and composed of cellulose and pectin and other organic and inorganic substances. IEA Catalysis of the reaction: UDP-glucose + glycogenin = UDP + glucosylglycogenin. IEA GO:0008466 glycogenin glucosyltransferase activity GSVIVG01019151001 16084015 16085284 GO:0030244 cellulose biosynthetic process The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation. IEA GO:0030054 cell junction A plasma membrane part that forms a specialized region of connection between two cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix. IEA Catalysis of the reaction: UDP-glucose + glycogenin = UDP + glucosylglycogenin. IEA GO:0008466 glycogenin glucosyltransferase activity GSVIVG01019151001 16084015 16085284 GO:0007047 cellular cell wall organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01019151001 16084015 16085284 GO:0007047 cellular cell wall organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. IEA GO:0009505 plant-type cell wall A more or less rigid stucture lying outside the cell membrane of a cell and composed of cellulose and pectin and other organic and inorganic substances. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01019151001 16084015 16085284 GO:0007047 cellular cell wall organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. IEA GO:0030054 cell junction A plasma membrane part that forms a specialized region of connection between two cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01019151001 16084015 16085284 GO:0030244 cellulose biosynthetic process The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01019151001 16084015 16085284 GO:0030244 cellulose biosynthetic process The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation. IEA GO:0009505 plant-type cell wall A more or less rigid stucture lying outside the cell membrane of a cell and composed of cellulose and pectin and other organic and inorganic substances. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01019151001 16084015 16085284 GO:0030244 cellulose biosynthetic process The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation. IEA GO:0030054 cell junction A plasma membrane part that forms a specialized region of connection between two cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01027640001 14769350 14771755 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027640001 14769350 14771755 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027640001 14769350 14771755 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027640001 14769350 14771755 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027640001 14769350 14771755 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027640001 14769350 14771755 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027640001 14769350 14771755 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+. IEA GO:0004459 L-lactate dehydrogenase activity GSVIVG01027640001 14769350 14771755 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+. IEA GO:0004459 L-lactate dehydrogenase activity GSVIVG01027640001 14769350 14771755 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+. IEA GO:0004459 L-lactate dehydrogenase activity GSVIVG01027640001 14769350 14771755 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+. IEA GO:0004459 L-lactate dehydrogenase activity GSVIVG01027640001 14769350 14771755 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+. IEA GO:0004459 L-lactate dehydrogenase activity GSVIVG01027640001 14769350 14771755 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+. IEA GO:0004459 L-lactate dehydrogenase activity GSVIVG01027640001 14769350 14771755 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027640001 14769350 14771755 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027640001 14769350 14771755 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027640001 14769350 14771755 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027640001 14769350 14771755 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027640001 14769350 14771755 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027640001 14769350 14771755 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01027640001 14769350 14771755 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01027640001 14769350 14771755 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01027640001 14769350 14771755 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01027640001 14769350 14771755 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01027640001 14769350 14771755 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01027640001 14769350 14771755 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01027640001 14769350 14771755 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01027640001 14769350 14771755 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01027640001 14769350 14771755 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01027640001 14769350 14771755 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01027640001 14769350 14771755 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01027640001 14769350 14771755 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01027640001 14769350 14771755 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01027640001 14769350 14771755 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01027640001 14769350 14771755 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01027640001 14769350 14771755 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01027640001 14769350 14771755 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01011804001 4016641 4021214 GSVIVG01019026001 17597612 17601315 GO:0006367 transcription initiation from RNA polymerase II promoter A transcription initiation process that results in RNA synthesis by RNA polymerase II. IEA GO:0005673 transcription factor TFIIE complex A transcription factor which in humans consists of a complex of two alpha and two beta chains. Recruits TFIIH to the initiation complex and helps activate both RNA polymerase II and TFIIH. IEA Functions to initiate or regulate RNA polymerase II transcription. IEA GO:0003702 RNA polymerase II transcription factor activity GSVIVG01008432001 2135973 2148416 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01008432001 2135973 2148416 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01008432001 2135973 2148416 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01008432001 2135973 2148416 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018982001 18102696 18105221 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01018982001 18102696 18105221 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01018982001 18102696 18105221 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01018982001 18102696 18105221 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012525001 594622 613113 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01031038001 21269585 21272018 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01031038001 21269585 21272018 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01031038001 21269585 21272018 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01031038001 21269585 21272018 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01021440001 5377031 5378228 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01036588001 18723793 18744366 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01036588001 18723793 18744366 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036588001 18723793 18744366 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01036588001 18723793 18744366 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01032993001 24943882 24944771 GSVIVG01006525001 42872760 42874345 GSVIVG01024558001 8858217 8858601 GSVIVG01013293001 334646 337614 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01013293001 334646 337614 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01013293001 334646 337614 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01013293001 334646 337614 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01013293001 334646 337614 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013293001 334646 337614 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017499001 9508653 9516717 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01017499001 9508653 9516717 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01017499001 9508653 9516717 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017499001 9508653 9516717 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017499001 9508653 9516717 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01017499001 9508653 9516717 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01017499001 9508653 9516717 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01017499001 9508653 9516717 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01011921001 3007049 3007411 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01011921001 3007049 3007411 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01011921001 3007049 3007411 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01011941001 2785841 2790833 GSVIVG01016750001 894732 897498 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01026150001 13049537 13052844 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01028707001 19584305 19587018 GO:0005992 trehalose biosynthetic process The chemical reactions and pathways resulting in the formation of trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028707001 19584305 19587018 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025480001 458612 484496 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01005337001 39747966 39749340 GSVIVG01038328001 13018383 13019322 GSVIVG01025321001 2042030 2047730 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01025321001 2042030 2047730 GO:0007601 visual perception The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01025321001 2042030 2047730 GO:0007602 phototransduction The sequence of reactions within a cell required to convert absorbed photons into a molecular signal. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01031570001 18299498 18311174 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01007435001 31867702 31869502 GSVIVG01022110001 16651426 16652337 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01022110001 16651426 16652337 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01022110001 16651426 16652337 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01013852001 5223827 5233716 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01013852001 5223827 5233716 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01035808001 4545234 4550231 GO:0006306 DNA methylation The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035592001 2577916 2581211 GSVIVG01034603001 14562762 14608387 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin. IEA GO:0004221 ubiquitin thiolesterase activity GSVIVG01031418001 18818716 18822205 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031418001 18818716 18822205 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031418001 18818716 18822205 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031418001 18818716 18822205 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031418001 18818716 18822205 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01031418001 18818716 18822205 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01035484001 1670195 1672597 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007759001 9350738 9350923 GSVIVG01023822001 3189941 3193848 GSVIVG01028226001 4770249 4773528 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). IEA GO:0003755 peptidyl-prolyl cis-trans isomerase activity GSVIVG01028226001 4770249 4773528 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. IEA GO:0016853 isomerase activity GSVIVG01009202001 6210895 6213254 GSVIVG01024413001 2220472 2245666 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01024413001 2220472 2245666 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01024413001 2220472 2245666 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01024413001 2220472 2245666 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01024413001 2220472 2245666 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01024413001 2220472 2245666 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01024413001 2220472 2245666 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01024413001 2220472 2245666 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01024413001 2220472 2245666 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01024413001 2220472 2245666 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01024413001 2220472 2245666 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01024413001 2220472 2245666 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01024413001 2220472 2245666 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01024413001 2220472 2245666 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01024413001 2220472 2245666 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01024413001 2220472 2245666 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01024413001 2220472 2245666 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01024413001 2220472 2245666 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01034896001 16184241 16187178 GSVIVG01007807001 8819087 8830876 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01007807001 8819087 8830876 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005761 mitochondrial ribosome A ribosome found in the mitochondrion of a eukaryotic cell; contains a characteristic set of proteins distinct from those of cytosolic ribosomes. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01007807001 8819087 8830876 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01025778001 11964680 11975563 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025778001 11964680 11975563 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025778001 11964680 11975563 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025778001 11964680 11975563 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025778001 11964680 11975563 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025778001 11964680 11975563 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025778001 11964680 11975563 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025778001 11964680 11975563 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025778001 11964680 11975563 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025778001 11964680 11975563 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01025778001 11964680 11975563 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01025778001 11964680 11975563 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01025778001 11964680 11975563 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01025778001 11964680 11975563 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01025778001 11964680 11975563 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01025778001 11964680 11975563 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01025778001 11964680 11975563 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01025778001 11964680 11975563 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01025778001 11964680 11975563 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01025778001 11964680 11975563 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01025778001 11964680 11975563 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01025778001 11964680 11975563 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01025778001 11964680 11975563 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01025778001 11964680 11975563 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01025778001 11964680 11975563 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01025778001 11964680 11975563 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01025778001 11964680 11975563 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01025778001 11964680 11975563 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01025778001 11964680 11975563 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01025778001 11964680 11975563 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01025778001 11964680 11975563 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01025778001 11964680 11975563 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01025778001 11964680 11975563 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01025778001 11964680 11975563 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01025778001 11964680 11975563 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01025778001 11964680 11975563 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01036696001 23780412 23784906 GSVIVG01038672001 21084821 21085998 GSVIVG01001049001 7045036 7053976 GSVIVG01010963001 2590067 2601347 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01010963001 2590067 2601347 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010963001 2590067 2601347 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01012621001 123365 129488 Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01021754001 10576755 10577918 GSVIVG01005312001 20617932 20619658 GSVIVG01024735001 7357338 7359696 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026955001 19044159 19057628 GSVIVG01032841001 331497 334109 GSVIVG01021735001 10323443 10325828 GSVIVG01013463001 237357 246044 GSVIVG01026588001 21315506 21327686 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01007482001 32193772 32195904 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01007482001 32193772 32195904 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01007482001 32193772 32195904 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01000517001 13561474 13571982 GSVIVG01008405001 2401130 2403917 GSVIVG01014327001 2686236 2691922 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01009172001 5715455 5718850 GSVIVG01009455001 8518635 8531571 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01009455001 8518635 8531571 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01009455001 8518635 8531571 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01033139001 8285869 8291277 GSVIVG01009780001 11199295 11200843 GSVIVG01033047001 25322305 25323151 GSVIVG01008074001 6042731 6050921 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008074001 6042731 6050921 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008074001 6042731 6050921 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008074001 6042731 6050921 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008074001 6042731 6050921 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008074001 6042731 6050921 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008074001 6042731 6050921 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008074001 6042731 6050921 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008074001 6042731 6050921 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008074001 6042731 6050921 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008074001 6042731 6050921 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008074001 6042731 6050921 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008074001 6042731 6050921 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01008074001 6042731 6050921 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01008074001 6042731 6050921 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01008074001 6042731 6050921 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01008074001 6042731 6050921 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01008074001 6042731 6050921 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01008074001 6042731 6050921 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01008074001 6042731 6050921 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01008074001 6042731 6050921 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01008074001 6042731 6050921 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01008074001 6042731 6050921 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01008074001 6042731 6050921 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01008074001 6042731 6050921 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01008074001 6042731 6050921 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01008074001 6042731 6050921 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01008074001 6042731 6050921 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01008074001 6042731 6050921 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01008074001 6042731 6050921 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01008855001 2855224 2860662 GSVIVG01009003001 4181109 4189953 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01012881001 6489128 6499411 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01012881001 6489128 6499411 Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01012881001 6489128 6499411 Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01038006001 12423832 12427497 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01038006001 12423832 12427497 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01038006001 12423832 12427497 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01038006001 12423832 12427497 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019877001 4146732 4149948 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01019877001 4146732 4149948 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01019877001 4146732 4149948 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01019877001 4146732 4149948 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01016459001 3693190 3696884 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01016459001 3693190 3696884 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01016459001 3693190 3696884 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01016459001 3693190 3696884 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01016459001 3693190 3696884 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016459001 3693190 3696884 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016459001 3693190 3696884 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016459001 3693190 3696884 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025234001 2899257 2905133 GSVIVG01008049001 6280175 6283955 GSVIVG01004704001 15370493 15372879 GSVIVG01012009001 2235673 2237099 GSVIVG01032393001 26916435 26919845 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032393001 26916435 26919845 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. IEA GO:0016853 isomerase activity GSVIVG01032393001 26916435 26919845 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01012197001 609375 618213 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01036659001 19931816 19941923 GSVIVG01015444001 3746759 3757181 GO:0006869 lipid transport The directed movement of lipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Interacting selectively and non-covalently with a lipid. IEA GO:0008289 lipid binding GSVIVG01025653001 13284105 13288412 GO:0008219 cell death A biological process that results in permanent cessation of all vital functions of a cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01018828001 19508700 19523351 GSVIVG01028719001 19472593 19474275 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01028719001 19472593 19474275 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01016208001 6603765 6608482 GSVIVG01004838001 5555760 5556550 GSVIVG01009045001 4517001 4530005 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01009045001 4517001 4530005 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01009045001 4517001 4530005 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01029651001 20188893 20191381 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01029651001 20188893 20191381 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01034793001 21736489 21737241 GSVIVG01016532001 3051355 3053980 GSVIVG01024018001 1722124 1725654 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01024018001 1722124 1725654 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01024018001 1722124 1725654 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01024018001 1722124 1725654 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01024018001 1722124 1725654 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01024018001 1722124 1725654 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01024018001 1722124 1725654 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01024018001 1722124 1725654 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01038135001 23726305 23741196 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GSVIVG01038135001 23726305 23741196 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GSVIVG01015329001 2744484 2751691 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01009143001 5485004 5490071 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01009143001 5485004 5490071 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01036885001 18248689 18251549 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01036885001 18248689 18251549 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01036885001 18248689 18251549 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01036885001 18248689 18251549 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01032828001 421193 455249 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01032828001 421193 455249 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01032828001 421193 455249 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032828001 421193 455249 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032828001 421193 455249 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01032828001 421193 455249 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01037759001 7636006 7640409 Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01037759001 7636006 7640409 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01037759001 7636006 7640409 Catalysis of the reaction: N(4)-{N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-N-acetyl-beta-D-glucosaminyl}asparagine + UDP-L-xylose = N(4)-{N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-[beta-D-xylosyl-(1,2)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-N-acetyl-beta-D-glucosaminyl}asparagine + UDP. IEA GO:0050513 glycoprotein 2-beta-D-xylosyltransferase activity GSVIVG01032667001 1666120 1667557 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01032667001 1666120 1667557 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01028434001 7492086 7494047 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009654 oxygen evolving complex A complex, composed of a cluster of manganese, calcium and chloride ions bound to extrinsic proteins, that catalyzes the splitting of water to O2 and 4 H+. In cyanobacteria there are five extrinsic proteins in OEC (PsbO, PsbP-like, PsbQ-like, PsbU and PsbV), while in plants there are only three (PsbO, PsbP and PsbQ). IEA GSVIVG01028434001 7492086 7494047 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01038086001 17767658 17774586 GSVIVG01034148001 14828040 14830056 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01034148001 14828040 14830056 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01018189001 13417086 13418212 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01018189001 13417086 13418212 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01005620001 40940152 40943169 GSVIVG01022640001 13992040 13995847 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01022640001 13992040 13995847 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01014252001 2024589 2027866 GSVIVG01025323001 2030667 2031473 GSVIVG01030372001 5063850 5073053 GSVIVG01032752001 1022036 1023024 GSVIVG01011377001 29151428 29152873 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01011377001 29151428 29152873 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01011377001 29151428 29152873 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01011377001 29151428 29152873 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01011377001 29151428 29152873 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01011377001 29151428 29152873 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01011377001 29151428 29152873 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01011377001 29151428 29152873 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01015036001 640389 643140 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038787001 898676 904397 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01001287001 5025234 5026199 GSVIVG01013233001 6473972 6482109 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01003454001 10360472 10376101 GSVIVG01036012001 7178804 7188084 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01036012001 7178804 7188084 GO:0006413 translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01036012001 7178804 7188084 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01036012001 7178804 7188084 GO:0006413 translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01036012001 7178804 7188084 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01036012001 7178804 7188084 GO:0006413 translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01036012001 7178804 7188084 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. IEA GO:0003743 translation initiation factor activity GSVIVG01036012001 7178804 7188084 GO:0006413 translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. IEA GO:0003743 translation initiation factor activity GSVIVG01020204001 9117653 9120234 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01003715001 15069074 15069976 GSVIVG01007917001 7542210 7555873 GSVIVG01009041001 4483321 4486706 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01022770001 16323605 16326902 GSVIVG01011001001 2308849 2316652 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01011001001 2308849 2316652 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01011001001 2308849 2316652 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01011001001 2308849 2316652 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01011001001 2308849 2316652 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01011001001 2308849 2316652 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01011001001 2308849 2316652 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01011001001 2308849 2316652 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01011001001 2308849 2316652 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01011001001 2308849 2316652 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01011001001 2308849 2316652 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01011001001 2308849 2316652 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01011001001 2308849 2316652 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01011001001 2308849 2316652 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01011001001 2308849 2316652 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01011001001 2308849 2316652 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01011001001 2308849 2316652 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01011001001 2308849 2316652 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01011001001 2308849 2316652 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01011001001 2308849 2316652 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01011001001 2308849 2316652 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01011001001 2308849 2316652 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01011001001 2308849 2316652 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01011001001 2308849 2316652 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01011001001 2308849 2316652 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01011001001 2308849 2316652 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01011001001 2308849 2316652 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01011001001 2308849 2316652 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01011001001 2308849 2316652 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01011001001 2308849 2316652 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01011001001 2308849 2316652 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01011001001 2308849 2316652 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01011001001 2308849 2316652 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01011001001 2308849 2316652 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01011001001 2308849 2316652 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01011001001 2308849 2316652 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01011001001 2308849 2316652 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01011001001 2308849 2316652 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01011001001 2308849 2316652 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01011001001 2308849 2316652 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01011001001 2308849 2316652 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01011001001 2308849 2316652 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01011001001 2308849 2316652 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01011001001 2308849 2316652 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01011001001 2308849 2316652 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01011001001 2308849 2316652 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01011001001 2308849 2316652 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01011001001 2308849 2316652 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01011001001 2308849 2316652 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01011001001 2308849 2316652 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01011001001 2308849 2316652 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01011001001 2308849 2316652 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01011001001 2308849 2316652 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01011001001 2308849 2316652 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01011001001 2308849 2316652 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01011001001 2308849 2316652 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01011001001 2308849 2316652 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01011001001 2308849 2316652 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01011001001 2308849 2316652 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01011001001 2308849 2316652 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01011001001 2308849 2316652 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01011001001 2308849 2316652 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01011001001 2308849 2316652 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01011001001 2308849 2316652 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01011001001 2308849 2316652 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01011001001 2308849 2316652 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01011001001 2308849 2316652 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01011001001 2308849 2316652 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01011001001 2308849 2316652 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01011001001 2308849 2316652 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01011001001 2308849 2316652 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01011001001 2308849 2316652 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01011001001 2308849 2316652 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01011001001 2308849 2316652 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01011001001 2308849 2316652 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01011001001 2308849 2316652 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01011001001 2308849 2316652 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01011001001 2308849 2316652 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01011001001 2308849 2316652 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01011001001 2308849 2316652 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01011001001 2308849 2316652 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor. IEA GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GSVIVG01011001001 2308849 2316652 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor. IEA GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GSVIVG01011001001 2308849 2316652 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor. IEA GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GSVIVG01011001001 2308849 2316652 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor. IEA GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GSVIVG01011001001 2308849 2316652 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor. IEA GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GSVIVG01011001001 2308849 2316652 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor. IEA GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GSVIVG01011001001 2308849 2316652 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor. IEA GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GSVIVG01011001001 2308849 2316652 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor. IEA GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GSVIVG01011001001 2308849 2316652 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor. IEA GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GSVIVG01011001001 2308849 2316652 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor. IEA GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GSVIVG01011001001 2308849 2316652 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor. IEA GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GSVIVG01011001001 2308849 2316652 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor. IEA GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GSVIVG01011001001 2308849 2316652 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor. IEA GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GSVIVG01011001001 2308849 2316652 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor. IEA GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GSVIVG01011001001 2308849 2316652 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor. IEA GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GSVIVG01011001001 2308849 2316652 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor. IEA GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GSVIVG01011001001 2308849 2316652 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01011001001 2308849 2316652 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01011001001 2308849 2316652 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01011001001 2308849 2316652 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01011001001 2308849 2316652 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01011001001 2308849 2316652 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01011001001 2308849 2316652 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01011001001 2308849 2316652 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01011001001 2308849 2316652 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01011001001 2308849 2316652 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01011001001 2308849 2316652 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01011001001 2308849 2316652 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01011001001 2308849 2316652 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01011001001 2308849 2316652 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01011001001 2308849 2316652 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01011001001 2308849 2316652 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01019049001 17380960 17385152 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019049001 17380960 17385152 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01034908001 18119 18457 GSVIVG01023630001 8234014 8235973 GSVIVG01009009001 4225459 4241443 GSVIVG01017679001 2574444 2574879 GSVIVG01019824001 3651997 3655704 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01037792001 7935404 7950401 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004185 serine-type carboxypeptidase activity GSVIVG01029299001 17365954 17369951 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01029299001 17365954 17369951 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01029299001 17365954 17369951 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029299001 17365954 17369951 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029299001 17365954 17369951 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029299001 17365954 17369951 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029299001 17365954 17369951 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01029299001 17365954 17369951 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01002381001 34508309 34508874 GSVIVG01026843001 20029744 20036824 GSVIVG01036250001 8084898 8085530 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01036250001 8084898 8085530 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01036250001 8084898 8085530 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01036400001 4629294 4635897 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01036400001 4629294 4635897 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01036400001 4629294 4635897 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01036400001 4629294 4635897 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01036400001 4629294 4635897 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01036400001 4629294 4635897 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01036400001 4629294 4635897 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01036400001 4629294 4635897 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01036400001 4629294 4635897 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036400001 4629294 4635897 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036400001 4629294 4635897 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036400001 4629294 4635897 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036400001 4629294 4635897 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036400001 4629294 4635897 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036400001 4629294 4635897 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036400001 4629294 4635897 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036400001 4629294 4635897 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01036400001 4629294 4635897 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01036400001 4629294 4635897 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01036400001 4629294 4635897 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01036400001 4629294 4635897 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01036400001 4629294 4635897 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01036400001 4629294 4635897 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01036400001 4629294 4635897 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01036272001 7665313 7667105 GSVIVG01038110001 23547820 23548882 GSVIVG01032070001 23002812 23003446 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01018990001 18026699 18028680 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01018990001 18026699 18028680 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01018990001 18026699 18028680 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01018990001 18026699 18028680 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01038613001 21470776 21473444 Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01029941001 1862461 1866343 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01007693001 10327128 10330607 GSVIVG01016386001 4314154 4314966 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01016386001 4314154 4314966 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01022623001 13595184 13673525 GSVIVG01011507001 30133925 30137019 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01011507001 30133925 30137019 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01011507001 30133925 30137019 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01011507001 30133925 30137019 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01011507001 30133925 30137019 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01011507001 30133925 30137019 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01011507001 30133925 30137019 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01011507001 30133925 30137019 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01011507001 30133925 30137019 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01011507001 30133925 30137019 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01011507001 30133925 30137019 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01011507001 30133925 30137019 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01025509001 173002 174251 GO:0009306 protein secretion The controlled release of proteins from a cell or group of cells. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01025509001 173002 174251 GO:0009306 protein secretion The controlled release of proteins from a cell or group of cells. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01025509001 173002 174251 GO:0009306 protein secretion The controlled release of proteins from a cell or group of cells. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01025509001 173002 174251 GO:0009664 plant-type cell wall organization A process that results in the assembly and arrangement of constituent parts of the cellulose and pectin-containing cell wall, or in the disassembly of the cellulose and pectin-containing cell wall. This process is carried out at the cellular level. An example of this process is found in Arabidopsis thaliana. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01025509001 173002 174251 GO:0009664 plant-type cell wall organization A process that results in the assembly and arrangement of constituent parts of the cellulose and pectin-containing cell wall, or in the disassembly of the cellulose and pectin-containing cell wall. This process is carried out at the cellular level. An example of this process is found in Arabidopsis thaliana. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01025509001 173002 174251 GO:0009664 plant-type cell wall organization A process that results in the assembly and arrangement of constituent parts of the cellulose and pectin-containing cell wall, or in the disassembly of the cellulose and pectin-containing cell wall. This process is carried out at the cellular level. An example of this process is found in Arabidopsis thaliana. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01024109001 996182 1004685 GO:0009116 nucleoside metabolic process The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine). IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033445001 20638631 20639387 GSVIVG01015144001 1340847 1346563 GSVIVG01017123001 4397370 4403625 GO:0046907 intracellular transport The directed movement of substances within a cell. IEA GSVIVG01006600001 26977150 26978957 GSVIVG01028914001 17593253 17594524 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01028914001 17593253 17594524 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024303001 688556 691178 GO:0006559 L-phenylalanine catabolic process The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024303001 688556 691178 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024303001 688556 691178 GO:0006559 L-phenylalanine catabolic process The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of ammonia (NH3) to another substance via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. IEA GO:0016211 ammonia ligase activity GSVIVG01024303001 688556 691178 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of ammonia (NH3) to another substance via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. IEA GO:0016211 ammonia ligase activity GSVIVG01024303001 688556 691178 GO:0006559 L-phenylalanine catabolic process The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate. IEA GO:0016841 ammonia-lyase activity GSVIVG01024303001 688556 691178 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate. IEA GO:0016841 ammonia-lyase activity GSVIVG01037639001 6453337 6454997 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01003703001 15233088 15245145 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01003703001 15233088 15245145 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035007001 850562 854096 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01035007001 850562 854096 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01035007001 850562 854096 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01035007001 850562 854096 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026483001 22891132 22902646 GSVIVG01014996001 266568 271675 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01014996001 266568 271675 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014996001 266568 271675 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01014996001 266568 271675 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01038674001 21079042 21081111 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GSVIVG01003936001 8115190 8145982 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01036354001 4139105 4143311 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01036354001 4139105 4143311 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01036354001 4139105 4143311 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01036354001 4139105 4143311 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01036354001 4139105 4143311 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01036354001 4139105 4143311 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01036354001 4139105 4143311 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01036354001 4139105 4143311 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01036354001 4139105 4143311 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036354001 4139105 4143311 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036354001 4139105 4143311 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036354001 4139105 4143311 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036354001 4139105 4143311 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036354001 4139105 4143311 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036354001 4139105 4143311 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036354001 4139105 4143311 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036354001 4139105 4143311 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01036354001 4139105 4143311 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01036354001 4139105 4143311 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01036354001 4139105 4143311 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01012178001 741222 751123 GSVIVG01008037001 6419636 6423672 GSVIVG01038772001 765824 766105 GSVIVG01010791001 22621138 22635498 GSVIVG01014346001 2853569 2853850 GSVIVG01014787001 9739588 9743061 GSVIVG01017014001 3466267 3469277 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01017014001 3466267 3469277 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01035240001 11130800 11137368 GO:0006102 isocitrate metabolic process The chemical reactions and pathways involving isocitrate, the anion of isocitric acid, 1-hydroxy-1,2,3-propanetricarboxylic acid. Isocitrate is an important intermediate in the TCA cycle and the glycoxylate cycle. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01035240001 11130800 11137368 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01035240001 11130800 11137368 GO:0006102 isocitrate metabolic process The chemical reactions and pathways involving isocitrate, the anion of isocitric acid, 1-hydroxy-1,2,3-propanetricarboxylic acid. Isocitrate is an important intermediate in the TCA cycle and the glycoxylate cycle. IEA Catalysis of the reaction: isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH + H+. IEA GO:0004450 isocitrate dehydrogenase (NADP+) activity GSVIVG01035240001 11130800 11137368 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH + H+. IEA GO:0004450 isocitrate dehydrogenase (NADP+) activity GSVIVG01035240001 11130800 11137368 GO:0006102 isocitrate metabolic process The chemical reactions and pathways involving isocitrate, the anion of isocitric acid, 1-hydroxy-1,2,3-propanetricarboxylic acid. Isocitrate is an important intermediate in the TCA cycle and the glycoxylate cycle. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01035240001 11130800 11137368 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01035240001 11130800 11137368 GO:0006102 isocitrate metabolic process The chemical reactions and pathways involving isocitrate, the anion of isocitric acid, 1-hydroxy-1,2,3-propanetricarboxylic acid. Isocitrate is an important intermediate in the TCA cycle and the glycoxylate cycle. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01035240001 11130800 11137368 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01035240001 11130800 11137368 GO:0006102 isocitrate metabolic process The chemical reactions and pathways involving isocitrate, the anion of isocitric acid, 1-hydroxy-1,2,3-propanetricarboxylic acid. Isocitrate is an important intermediate in the TCA cycle and the glycoxylate cycle. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01035240001 11130800 11137368 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01001948001 15206279 15209463 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and carries out proton transport across a membrane. The proton-transporting domain (F0, V0, or A0) includes integral and peripheral membrane proteins. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01013228001 6526981 6534000 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01013228001 6526981 6534000 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01007417001 31682231 31682894 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01007417001 31682231 31682894 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01007417001 31682231 31682894 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01007417001 31682231 31682894 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01030569001 6821342 6825102 GO:0006364 rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. IEA GO:0005732 small nucleolar ribonucleoprotein complex A ribonucleoprotein complex that contains a small nucleolar RNA (snoRNA) and associated proteins, and is found in eukaryotic cells. Most are involved in a step of processing of rRNA: cleavage, 2'-O-methylation, or pseudouridylation. The majority, though not all, fall into one of two classes, box C/D type or box H/ACA type. IEA Interacting selectively and non-covalently with ribosomal RNA. IEA GO:0019843 rRNA binding GSVIVG01020031001 11312668 11322931 GO:0015770 sucrose transport The directed movement of sucrose into, out of, within or between cells by means of some external agent such as a transporter or pore. Sucrose is the disaccharide fructofuranosyl-glucopyranoside. IEA GO:0005887 integral to plasma membrane Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Catalysis of the transfer of sucrose from one side of the membrane to the other. Sucrose is the disaccharide O-beta-D-fructofuranosyl-(2->1)-alpha-D-glucopyranoside, a sweet-tasting, non-reducing sugar isolated industrially from sugar beet or sugar cane. IEA GO:0008515 sucrose transmembrane transporter activity GSVIVG01020031001 11312668 11322931 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005887 integral to plasma membrane Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Catalysis of the transfer of sucrose from one side of the membrane to the other. Sucrose is the disaccharide O-beta-D-fructofuranosyl-(2->1)-alpha-D-glucopyranoside, a sweet-tasting, non-reducing sugar isolated industrially from sugar beet or sugar cane. IEA GO:0008515 sucrose transmembrane transporter activity GSVIVG01020063001 10908568 10915503 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01020063001 10908568 10915503 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01020063001 10908568 10915503 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01020063001 10908568 10915503 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01003148001 6217557 6226884 GO:0001522 pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01003148001 6217557 6226884 GO:0009451 RNA modification The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01003148001 6217557 6226884 GO:0001522 pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs. IEA Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. IEA GO:0009982 pseudouridine synthase activity GSVIVG01003148001 6217557 6226884 GO:0009451 RNA modification The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. IEA Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. IEA GO:0009982 pseudouridine synthase activity GSVIVG01004823001 5444669 5445461 GSVIVG01038493001 10340548 10343355 GSVIVG01009201001 6203361 6209638 GSVIVG01014251001 2019134 2022522 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01014251001 2019134 2022522 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01014251001 2019134 2022522 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01014251001 2019134 2022522 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01014251001 2019134 2022522 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01014251001 2019134 2022522 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01014251001 2019134 2022522 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01014251001 2019134 2022522 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01014251001 2019134 2022522 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01014251001 2019134 2022522 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01014251001 2019134 2022522 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01014251001 2019134 2022522 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01014251001 2019134 2022522 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01014251001 2019134 2022522 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01014251001 2019134 2022522 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01014251001 2019134 2022522 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01014251001 2019134 2022522 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01014251001 2019134 2022522 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01014251001 2019134 2022522 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01014251001 2019134 2022522 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01014251001 2019134 2022522 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01014251001 2019134 2022522 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01014251001 2019134 2022522 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01014251001 2019134 2022522 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01023182001 21498622 21499431 GSVIVG01007567001 11926721 11926825 GSVIVG01021424001 5178906 5206434 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01005286001 536613 538336 GSVIVG01007729001 9862859 9868352 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01007729001 9862859 9868352 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01010120001 15794280 15805183 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010120001 15794280 15805183 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010120001 15794280 15805183 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01010120001 15794280 15805183 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01023086001 15519499 15523443 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. IEA GO:0004725 protein tyrosine phosphatase activity GSVIVG01020234001 8738934 8766205 GSVIVG01032066001 23074379 23089533 GO:0006397 mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01032066001 23074379 23089533 GO:0006397 mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01032634001 1989562 2005300 GSVIVG01038423001 12059579 12061112 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01033886001 17020368 17022277 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01028686001 12115516 12121876 GSVIVG01001593001 18146215 18146944 GSVIVG01034511001 20141274 20145463 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin. IEA GO:0004221 ubiquitin thiolesterase activity GSVIVG01027566001 15519746 15520962 GSVIVG01031074001 21859980 21865827 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031074001 21859980 21865827 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01034955001 422189 430622 GSVIVG01023803001 3360709 3368408 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01023803001 3360709 3368408 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01022382001 19422802 19425758 GSVIVG01023236001 20811695 20814701 GSVIVG01024733001 7370378 7375108 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = D-myo-inositol 1,4,5-trisphosphate + diacylglycerol. IEA GO:0004435 phosphoinositide phospholipase C activity GSVIVG01024733001 7370378 7375108 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = D-myo-inositol 1,4,5-trisphosphate + diacylglycerol. IEA GO:0004435 phosphoinositide phospholipase C activity GSVIVG01024733001 7370378 7375108 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate. IEA GO:0004629 phospholipase C activity GSVIVG01024733001 7370378 7375108 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate. IEA GO:0004629 phospholipase C activity GSVIVG01024733001 7370378 7375108 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. IEA GO:0008081 phosphoric diester hydrolase activity GSVIVG01024733001 7370378 7375108 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. IEA GO:0008081 phosphoric diester hydrolase activity GSVIVG01019741001 2883747 2889066 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019741001 2883747 2889066 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019741001 2883747 2889066 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019741001 2883747 2889066 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019741001 2883747 2889066 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019741001 2883747 2889066 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019741001 2883747 2889066 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01019741001 2883747 2889066 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01019741001 2883747 2889066 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01019741001 2883747 2889066 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01019741001 2883747 2889066 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01019741001 2883747 2889066 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01026712001 5327791 5328495 GSVIVG01027598001 15171890 15174237 GSVIVG01009646001 10174163 10175673 GSVIVG01024760001 7166910 7169739 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01024760001 7166910 7169739 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01024760001 7166910 7169739 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01024760001 7166910 7169739 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033983001 16115459 16119117 GSVIVG01007750001 9600464 9610562 GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA GSVIVG01007750001 9600464 9610562 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01000453001 8142427 8145436 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+. IEA GO:0008121 ubiquinol-cytochrome-c reductase activity GSVIVG01000453001 8142427 8145436 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0042651 thylakoid membrane The pigmented membrane of any thylakoid. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+. IEA GO:0008121 ubiquinol-cytochrome-c reductase activity GSVIVG01000453001 8142427 8145436 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: plastoquinol-1 + 2 oxidized plastocyanin = plastoquinone + 2 reduced plastocyanin. IEA GO:0009496 plastoquinol-plastocyanin reductase activity GSVIVG01000453001 8142427 8145436 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0042651 thylakoid membrane The pigmented membrane of any thylakoid. IEA Catalysis of the reaction: plastoquinol-1 + 2 oxidized plastocyanin = plastoquinone + 2 reduced plastocyanin. IEA GO:0009496 plastoquinol-plastocyanin reductase activity GSVIVG01000453001 8142427 8145436 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01000453001 8142427 8145436 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0042651 thylakoid membrane The pigmented membrane of any thylakoid. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01000453001 8142427 8145436 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction in which a diphenol or related substance acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016679 oxidoreductase activity, acting on diphenols and related substances as donors GSVIVG01000453001 8142427 8145436 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0042651 thylakoid membrane The pigmented membrane of any thylakoid. IEA Catalysis of an oxidation-reduction (redox) reaction in which a diphenol or related substance acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016679 oxidoreductase activity, acting on diphenols and related substances as donors GSVIVG01000453001 8142427 8145436 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051537 2 iron, 2 sulfur cluster binding GSVIVG01000453001 8142427 8145436 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0042651 thylakoid membrane The pigmented membrane of any thylakoid. IEA Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051537 2 iron, 2 sulfur cluster binding GSVIVG01001374001 24084105 24087122 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01036977001 9341916 9347312 GSVIVG01034638001 13578061 13578390 GSVIVG01020252001 22237214 22253133 GSVIVG01027723001 7139729 7144533 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01027723001 7139729 7144533 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01027723001 7139729 7144533 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027723001 7139729 7144533 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001564001 202099 204749 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01001564001 202099 204749 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01001564001 202099 204749 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001564001 202099 204749 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009404001 8045604 8049549 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01009404001 8045604 8049549 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01009404001 8045604 8049549 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01009404001 8045604 8049549 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01014169001 1048082 1053505 GSVIVG01037795001 7888986 7890280 GSVIVG01036322001 3776068 3798237 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01036322001 3776068 3798237 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01035404001 1044794 1048906 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid. IEA GO:0008378 galactosyltransferase activity GSVIVG01035404001 1044794 1048906 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid. IEA GO:0008378 galactosyltransferase activity GSVIVG01035404001 1044794 1048906 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid. IEA GO:0008378 galactosyltransferase activity GSVIVG01035404001 1044794 1048906 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01035404001 1044794 1048906 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01035404001 1044794 1048906 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01035404001 1044794 1048906 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01035404001 1044794 1048906 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01035404001 1044794 1048906 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01003834001 20522829 20529516 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01003834001 20522829 20529516 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01003834001 20522829 20529516 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01003834001 20522829 20529516 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01013672001 2367058 2383189 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01013672001 2367058 2383189 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01013672001 2367058 2383189 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01013672001 2367058 2383189 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01009222001 6398183 6405987 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GSVIVG01013373001 874266 900936 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with the hedgehog protein to initiate a change in cell activity. IEA GO:0008158 hedgehog receptor activity GSVIVG01013373001 874266 900936 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with the hedgehog protein to initiate a change in cell activity. IEA GO:0008158 hedgehog receptor activity GSVIVG01013373001 874266 900936 GO:0030301 cholesterol transport The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with the hedgehog protein to initiate a change in cell activity. IEA GO:0008158 hedgehog receptor activity GSVIVG01013373001 874266 900936 GO:0030301 cholesterol transport The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with the hedgehog protein to initiate a change in cell activity. IEA GO:0008158 hedgehog receptor activity GSVIVG01013373001 874266 900936 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01013373001 874266 900936 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01013373001 874266 900936 GO:0030301 cholesterol transport The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01013373001 874266 900936 GO:0030301 cholesterol transport The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01027256001 17536165 17536410 GSVIVG01033150001 8473898 8482145 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01033150001 8473898 8482145 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01033150001 8473898 8482145 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01033150001 8473898 8482145 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01033150001 8473898 8482145 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01033150001 8473898 8482145 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01033150001 8473898 8482145 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033150001 8473898 8482145 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033150001 8473898 8482145 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033150001 8473898 8482145 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033150001 8473898 8482145 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033150001 8473898 8482145 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033150001 8473898 8482145 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033150001 8473898 8482145 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033150001 8473898 8482145 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033150001 8473898 8482145 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033150001 8473898 8482145 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033150001 8473898 8482145 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033150001 8473898 8482145 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01033150001 8473898 8482145 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01033150001 8473898 8482145 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01033150001 8473898 8482145 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01033150001 8473898 8482145 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01033150001 8473898 8482145 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01007421001 31709146 31715749 Catalysis of the removal of a phosphate group from phosphorylated myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol. IEA GO:0004437 inositol or phosphatidylinositol phosphatase activity GSVIVG01019005001 17884133 17886811 Functions in the storage of nutritious substrates. IEA GO:0045735 nutrient reservoir activity GSVIVG01006160001 42281041 42282650 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01006160001 42281041 42282650 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01006160001 42281041 42282650 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01006160001 42281041 42282650 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01006160001 42281041 42282650 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006160001 42281041 42282650 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012301001 13223282 13230139 GSVIVG01012975001 10872893 10872997 GSVIVG01024523001 9241441 9242928 GSVIVG01022136001 16852540 16859877 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01022136001 16852540 16859877 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01022136001 16852540 16859877 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01022136001 16852540 16859877 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01023836001 3078820 3096034 GO:0006278 RNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01023836001 3078820 3096034 GO:0006278 RNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01023836001 3078820 3096034 GO:0006821 chloride transport The directed movement of chloride into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01023836001 3078820 3096034 GO:0006821 chloride transport The directed movement of chloride into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01023836001 3078820 3096034 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01023836001 3078820 3096034 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01023836001 3078820 3096034 GO:0006278 RNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time. IEA GO:0003964 RNA-directed DNA polymerase activity GSVIVG01023836001 3078820 3096034 GO:0006278 RNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time. IEA GO:0003964 RNA-directed DNA polymerase activity GSVIVG01023836001 3078820 3096034 GO:0006821 chloride transport The directed movement of chloride into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time. IEA GO:0003964 RNA-directed DNA polymerase activity GSVIVG01023836001 3078820 3096034 GO:0006821 chloride transport The directed movement of chloride into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time. IEA GO:0003964 RNA-directed DNA polymerase activity GSVIVG01023836001 3078820 3096034 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time. IEA GO:0003964 RNA-directed DNA polymerase activity GSVIVG01023836001 3078820 3096034 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time. IEA GO:0003964 RNA-directed DNA polymerase activity GSVIVG01023836001 3078820 3096034 GO:0006278 RNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01023836001 3078820 3096034 GO:0006278 RNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01023836001 3078820 3096034 GO:0006821 chloride transport The directed movement of chloride into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01023836001 3078820 3096034 GO:0006821 chloride transport The directed movement of chloride into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01023836001 3078820 3096034 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01023836001 3078820 3096034 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01023836001 3078820 3096034 GO:0006278 RNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a chloride ion by a voltage-gated channel. IEA GO:0005247 voltage-gated chloride channel activity GSVIVG01023836001 3078820 3096034 GO:0006278 RNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of a chloride ion by a voltage-gated channel. IEA GO:0005247 voltage-gated chloride channel activity GSVIVG01023836001 3078820 3096034 GO:0006821 chloride transport The directed movement of chloride into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a chloride ion by a voltage-gated channel. IEA GO:0005247 voltage-gated chloride channel activity GSVIVG01023836001 3078820 3096034 GO:0006821 chloride transport The directed movement of chloride into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of a chloride ion by a voltage-gated channel. IEA GO:0005247 voltage-gated chloride channel activity GSVIVG01023836001 3078820 3096034 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a chloride ion by a voltage-gated channel. IEA GO:0005247 voltage-gated chloride channel activity GSVIVG01023836001 3078820 3096034 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of a chloride ion by a voltage-gated channel. IEA GO:0005247 voltage-gated chloride channel activity GSVIVG01036077001 21010595 21012311 GSVIVG01011928001 2948265 2949046 GSVIVG01007551001 12257609 12259195 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with the tumor necrosis factor receptor. IEA GO:0005164 tumor necrosis factor receptor binding GSVIVG01007551001 12257609 12259195 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with the tumor necrosis factor receptor. IEA GO:0005164 tumor necrosis factor receptor binding GSVIVG01007551001 12257609 12259195 GO:0006955 immune response Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with the tumor necrosis factor receptor. IEA GO:0005164 tumor necrosis factor receptor binding GSVIVG01007551001 12257609 12259195 GO:0006955 immune response Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with the tumor necrosis factor receptor. IEA GO:0005164 tumor necrosis factor receptor binding GSVIVG01007551001 12257609 12259195 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with the tumor necrosis factor receptor. IEA GO:0005164 tumor necrosis factor receptor binding GSVIVG01007551001 12257609 12259195 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with the tumor necrosis factor receptor. IEA GO:0005164 tumor necrosis factor receptor binding GSVIVG01007551001 12257609 12259195 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01007551001 12257609 12259195 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01007551001 12257609 12259195 GO:0006955 immune response Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01007551001 12257609 12259195 GO:0006955 immune response Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01007551001 12257609 12259195 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01007551001 12257609 12259195 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01013261001 6123710 6126522 GSVIVG01029276001 17688037 17692060 GSVIVG01026529001 22226309 22252207 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01026529001 22226309 22252207 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01019467001 870871 883981 GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01019467001 870871 883981 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01019467001 870871 883981 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01019467001 870871 883981 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01019467001 870871 883981 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01019467001 870871 883981 GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019467001 870871 883981 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019467001 870871 883981 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019467001 870871 883981 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019467001 870871 883981 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019467001 870871 883981 GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+. IEA GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity GSVIVG01019467001 870871 883981 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+. IEA GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity GSVIVG01019467001 870871 883981 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+. IEA GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity GSVIVG01019467001 870871 883981 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+. IEA GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity GSVIVG01019467001 870871 883981 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+. IEA GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity GSVIVG01019467001 870871 883981 GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019467001 870871 883981 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019467001 870871 883981 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019467001 870871 883981 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019467001 870871 883981 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019467001 870871 883981 GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019467001 870871 883981 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019467001 870871 883981 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019467001 870871 883981 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019467001 870871 883981 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019467001 870871 883981 GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01019467001 870871 883981 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01019467001 870871 883981 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01019467001 870871 883981 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01019467001 870871 883981 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01019467001 870871 883981 GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01019467001 870871 883981 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01019467001 870871 883981 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01019467001 870871 883981 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01019467001 870871 883981 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01019467001 870871 883981 GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01019467001 870871 883981 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01019467001 870871 883981 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01019467001 870871 883981 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01019467001 870871 883981 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01019467001 870871 883981 GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01019467001 870871 883981 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01019467001 870871 883981 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01019467001 870871 883981 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01019467001 870871 883981 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01019467001 870871 883981 GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01019467001 870871 883981 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01019467001 870871 883981 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01019467001 870871 883981 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01019467001 870871 883981 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01019467001 870871 883981 GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01019467001 870871 883981 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01019467001 870871 883981 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01019467001 870871 883981 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01019467001 870871 883981 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01022020001 4240519 4249252 GSVIVG01009911001 12314822 12316170 GSVIVG01026550001 21941209 21942857 GSVIVG01010483001 20954686 20957185 GO:0009765 photosynthesis, light harvesting Absorption and transfer of the energy absorbed from light photons between photosystem reaction centers. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA GSVIVG01010483001 20954686 20957185 GO:0009765 photosynthesis, light harvesting Absorption and transfer of the energy absorbed from light photons between photosystem reaction centers. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01003177001 5961868 5961984 GSVIVG01017115001 4297470 4302349 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01017115001 4297470 4302349 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01017115001 4297470 4302349 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01017115001 4297470 4302349 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01000438001 8023972 8027078 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01000438001 8023972 8027078 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01000438001 8023972 8027078 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01000438001 8023972 8027078 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01000438001 8023972 8027078 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01000438001 8023972 8027078 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01000438001 8023972 8027078 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000438001 8023972 8027078 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012244001 258817 261979 GO:0007047 cellular cell wall organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA Catalysis of the reaction: UDP-glucose + glycogenin = UDP + glucosylglycogenin. IEA GO:0008466 glycogenin glucosyltransferase activity GSVIVG01012244001 258817 261979 GO:0007047 cellular cell wall organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. IEA GO:0009505 plant-type cell wall A more or less rigid stucture lying outside the cell membrane of a cell and composed of cellulose and pectin and other organic and inorganic substances. IEA Catalysis of the reaction: UDP-glucose + glycogenin = UDP + glucosylglycogenin. IEA GO:0008466 glycogenin glucosyltransferase activity GSVIVG01012244001 258817 261979 GO:0007047 cellular cell wall organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. IEA GO:0030054 cell junction A plasma membrane part that forms a specialized region of connection between two cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix. IEA Catalysis of the reaction: UDP-glucose + glycogenin = UDP + glucosylglycogenin. IEA GO:0008466 glycogenin glucosyltransferase activity GSVIVG01012244001 258817 261979 GO:0030244 cellulose biosynthetic process The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA Catalysis of the reaction: UDP-glucose + glycogenin = UDP + glucosylglycogenin. IEA GO:0008466 glycogenin glucosyltransferase activity GSVIVG01012244001 258817 261979 GO:0030244 cellulose biosynthetic process The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation. IEA GO:0009505 plant-type cell wall A more or less rigid stucture lying outside the cell membrane of a cell and composed of cellulose and pectin and other organic and inorganic substances. IEA Catalysis of the reaction: UDP-glucose + glycogenin = UDP + glucosylglycogenin. IEA GO:0008466 glycogenin glucosyltransferase activity GSVIVG01012244001 258817 261979 GO:0030244 cellulose biosynthetic process The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation. IEA GO:0030054 cell junction A plasma membrane part that forms a specialized region of connection between two cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix. IEA Catalysis of the reaction: UDP-glucose + glycogenin = UDP + glucosylglycogenin. IEA GO:0008466 glycogenin glucosyltransferase activity GSVIVG01012244001 258817 261979 GO:0007047 cellular cell wall organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01012244001 258817 261979 GO:0007047 cellular cell wall organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. IEA GO:0009505 plant-type cell wall A more or less rigid stucture lying outside the cell membrane of a cell and composed of cellulose and pectin and other organic and inorganic substances. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01012244001 258817 261979 GO:0007047 cellular cell wall organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. IEA GO:0030054 cell junction A plasma membrane part that forms a specialized region of connection between two cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01012244001 258817 261979 GO:0030244 cellulose biosynthetic process The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01012244001 258817 261979 GO:0030244 cellulose biosynthetic process The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation. IEA GO:0009505 plant-type cell wall A more or less rigid stucture lying outside the cell membrane of a cell and composed of cellulose and pectin and other organic and inorganic substances. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01012244001 258817 261979 GO:0030244 cellulose biosynthetic process The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation. IEA GO:0030054 cell junction A plasma membrane part that forms a specialized region of connection between two cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01008230001 4393226 4459556 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008230001 4393226 4459556 Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008237 metallopeptidase activity GSVIVG01008230001 4393226 4459556 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01013887001 6115901 6116740 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01035622001 2765834 2766476 GSVIVG01028391001 7041479 7045005 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with calcitonin to initiate a change in cell activity. IEA GO:0004948 calcitonin receptor activity GSVIVG01028391001 7041479 7045005 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with calcitonin to initiate a change in cell activity. IEA GO:0004948 calcitonin receptor activity GSVIVG01028391001 7041479 7045005 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01028391001 7041479 7045005 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01030876001 18194432 18202733 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01000182001 15956383 15958188 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01000182001 15956383 15958188 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01000182001 15956383 15958188 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01000182001 15956383 15958188 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01031354001 115071 121673 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01031354001 115071 121673 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01031354001 115071 121673 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01031354001 115071 121673 GO:0007600 sensory perception The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01031354001 115071 121673 GO:0009585 red, far-red light phototransduction The sequence of reactions within a cell required to convert absorbed photons from red or far-red light into a molecular signal; the red, far-red light range is defined as having a wavelength within the range 660-730 nm. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01031354001 115071 121673 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01031354001 115071 121673 GO:0017006 protein-tetrapyrrole linkage The covalent linking of a tetrapyrrole to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01031354001 115071 121673 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01031354001 115071 121673 GO:0018298 protein-chromophore linkage The covalent or noncovalent linking of a chromophore to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01031354001 115071 121673 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01031354001 115071 121673 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01031354001 115071 121673 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01031354001 115071 121673 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01031354001 115071 121673 GO:0007600 sensory perception The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01031354001 115071 121673 GO:0009585 red, far-red light phototransduction The sequence of reactions within a cell required to convert absorbed photons from red or far-red light into a molecular signal; the red, far-red light range is defined as having a wavelength within the range 660-730 nm. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01031354001 115071 121673 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01031354001 115071 121673 GO:0017006 protein-tetrapyrrole linkage The covalent linking of a tetrapyrrole to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01031354001 115071 121673 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01031354001 115071 121673 GO:0018298 protein-chromophore linkage The covalent or noncovalent linking of a chromophore to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01031354001 115071 121673 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01031354001 115071 121673 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01031354001 115071 121673 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01031354001 115071 121673 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01031354001 115071 121673 GO:0007600 sensory perception The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01031354001 115071 121673 GO:0009585 red, far-red light phototransduction The sequence of reactions within a cell required to convert absorbed photons from red or far-red light into a molecular signal; the red, far-red light range is defined as having a wavelength within the range 660-730 nm. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01031354001 115071 121673 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01031354001 115071 121673 GO:0017006 protein-tetrapyrrole linkage The covalent linking of a tetrapyrrole to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01031354001 115071 121673 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01031354001 115071 121673 GO:0018298 protein-chromophore linkage The covalent or noncovalent linking of a chromophore to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01031354001 115071 121673 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01031354001 115071 121673 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01031354001 115071 121673 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01031354001 115071 121673 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01031354001 115071 121673 GO:0007600 sensory perception The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01031354001 115071 121673 GO:0009585 red, far-red light phototransduction The sequence of reactions within a cell required to convert absorbed photons from red or far-red light into a molecular signal; the red, far-red light range is defined as having a wavelength within the range 660-730 nm. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01031354001 115071 121673 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01031354001 115071 121673 GO:0017006 protein-tetrapyrrole linkage The covalent linking of a tetrapyrrole to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01031354001 115071 121673 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01031354001 115071 121673 GO:0018298 protein-chromophore linkage The covalent or noncovalent linking of a chromophore to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01031354001 115071 121673 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01031354001 115071 121673 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031354001 115071 121673 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031354001 115071 121673 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031354001 115071 121673 GO:0007600 sensory perception The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031354001 115071 121673 GO:0009585 red, far-red light phototransduction The sequence of reactions within a cell required to convert absorbed photons from red or far-red light into a molecular signal; the red, far-red light range is defined as having a wavelength within the range 660-730 nm. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031354001 115071 121673 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031354001 115071 121673 GO:0017006 protein-tetrapyrrole linkage The covalent linking of a tetrapyrrole to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031354001 115071 121673 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031354001 115071 121673 GO:0018298 protein-chromophore linkage The covalent or noncovalent linking of a chromophore to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031354001 115071 121673 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031354001 115071 121673 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A G-protein coupled receptor that responds to incidental electromagnetic radiation, particularly visible light. IEA GO:0008020 G-protein coupled photoreceptor activity GSVIVG01031354001 115071 121673 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A G-protein coupled receptor that responds to incidental electromagnetic radiation, particularly visible light. IEA GO:0008020 G-protein coupled photoreceptor activity GSVIVG01031354001 115071 121673 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A G-protein coupled receptor that responds to incidental electromagnetic radiation, particularly visible light. IEA GO:0008020 G-protein coupled photoreceptor activity GSVIVG01031354001 115071 121673 GO:0007600 sensory perception The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A G-protein coupled receptor that responds to incidental electromagnetic radiation, particularly visible light. IEA GO:0008020 G-protein coupled photoreceptor activity GSVIVG01031354001 115071 121673 GO:0009585 red, far-red light phototransduction The sequence of reactions within a cell required to convert absorbed photons from red or far-red light into a molecular signal; the red, far-red light range is defined as having a wavelength within the range 660-730 nm. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A G-protein coupled receptor that responds to incidental electromagnetic radiation, particularly visible light. IEA GO:0008020 G-protein coupled photoreceptor activity GSVIVG01031354001 115071 121673 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A G-protein coupled receptor that responds to incidental electromagnetic radiation, particularly visible light. IEA GO:0008020 G-protein coupled photoreceptor activity GSVIVG01031354001 115071 121673 GO:0017006 protein-tetrapyrrole linkage The covalent linking of a tetrapyrrole to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A G-protein coupled receptor that responds to incidental electromagnetic radiation, particularly visible light. IEA GO:0008020 G-protein coupled photoreceptor activity GSVIVG01031354001 115071 121673 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A G-protein coupled receptor that responds to incidental electromagnetic radiation, particularly visible light. IEA GO:0008020 G-protein coupled photoreceptor activity GSVIVG01031354001 115071 121673 GO:0018298 protein-chromophore linkage The covalent or noncovalent linking of a chromophore to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A G-protein coupled receptor that responds to incidental electromagnetic radiation, particularly visible light. IEA GO:0008020 G-protein coupled photoreceptor activity GSVIVG01031354001 115071 121673 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A G-protein coupled receptor that responds to incidental electromagnetic radiation, particularly visible light. IEA GO:0008020 G-protein coupled photoreceptor activity GSVIVG01031354001 115071 121673 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation. IEA GO:0009881 photoreceptor activity GSVIVG01031354001 115071 121673 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation. IEA GO:0009881 photoreceptor activity GSVIVG01031354001 115071 121673 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation. IEA GO:0009881 photoreceptor activity GSVIVG01031354001 115071 121673 GO:0007600 sensory perception The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation. IEA GO:0009881 photoreceptor activity GSVIVG01031354001 115071 121673 GO:0009585 red, far-red light phototransduction The sequence of reactions within a cell required to convert absorbed photons from red or far-red light into a molecular signal; the red, far-red light range is defined as having a wavelength within the range 660-730 nm. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation. IEA GO:0009881 photoreceptor activity GSVIVG01031354001 115071 121673 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation. IEA GO:0009881 photoreceptor activity GSVIVG01031354001 115071 121673 GO:0017006 protein-tetrapyrrole linkage The covalent linking of a tetrapyrrole to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation. IEA GO:0009881 photoreceptor activity GSVIVG01031354001 115071 121673 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation. IEA GO:0009881 photoreceptor activity GSVIVG01031354001 115071 121673 GO:0018298 protein-chromophore linkage The covalent or noncovalent linking of a chromophore to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation. IEA GO:0009881 photoreceptor activity GSVIVG01031354001 115071 121673 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation. IEA GO:0009881 photoreceptor activity GSVIVG01031354001 115071 121673 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01031354001 115071 121673 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01031354001 115071 121673 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01031354001 115071 121673 GO:0007600 sensory perception The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01031354001 115071 121673 GO:0009585 red, far-red light phototransduction The sequence of reactions within a cell required to convert absorbed photons from red or far-red light into a molecular signal; the red, far-red light range is defined as having a wavelength within the range 660-730 nm. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01031354001 115071 121673 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01031354001 115071 121673 GO:0017006 protein-tetrapyrrole linkage The covalent linking of a tetrapyrrole to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01031354001 115071 121673 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01031354001 115071 121673 GO:0018298 protein-chromophore linkage The covalent or noncovalent linking of a chromophore to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01031354001 115071 121673 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01031354001 115071 121673 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with an identical protein to form a homodimer. IEA GO:0042803 protein homodimerization activity GSVIVG01031354001 115071 121673 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with an identical protein to form a homodimer. IEA GO:0042803 protein homodimerization activity GSVIVG01031354001 115071 121673 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with an identical protein to form a homodimer. IEA GO:0042803 protein homodimerization activity GSVIVG01031354001 115071 121673 GO:0007600 sensory perception The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with an identical protein to form a homodimer. IEA GO:0042803 protein homodimerization activity GSVIVG01031354001 115071 121673 GO:0009585 red, far-red light phototransduction The sequence of reactions within a cell required to convert absorbed photons from red or far-red light into a molecular signal; the red, far-red light range is defined as having a wavelength within the range 660-730 nm. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with an identical protein to form a homodimer. IEA GO:0042803 protein homodimerization activity GSVIVG01031354001 115071 121673 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with an identical protein to form a homodimer. IEA GO:0042803 protein homodimerization activity GSVIVG01031354001 115071 121673 GO:0017006 protein-tetrapyrrole linkage The covalent linking of a tetrapyrrole to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with an identical protein to form a homodimer. IEA GO:0042803 protein homodimerization activity GSVIVG01031354001 115071 121673 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with an identical protein to form a homodimer. IEA GO:0042803 protein homodimerization activity GSVIVG01031354001 115071 121673 GO:0018298 protein-chromophore linkage The covalent or noncovalent linking of a chromophore to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with an identical protein to form a homodimer. IEA GO:0042803 protein homodimerization activity GSVIVG01031354001 115071 121673 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with an identical protein to form a homodimer. IEA GO:0042803 protein homodimerization activity GSVIVG01025008001 5325032 5343373 GSVIVG01037750001 7494806 7501203 Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01028328001 6210900 6212796 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012958001 11781088 11782139 GSVIVG01003697001 15299383 15301022 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01001108001 22685709 22688351 GSVIVG01000170001 15840160 15846953 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01002338001 34203613 34204150 GSVIVG01019517001 1260784 1263800 GSVIVG01026145001 12936187 12943830 GO:0016068 type I hypersensitivity An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells or basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01026145001 12936187 12943830 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01026145001 12936187 12943830 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01020238001 8694650 8695830 GSVIVG01024770001 7107663 7113284 GO:0000162 tryptophan biosynthetic process The chemical reactions and pathways resulting in the formation of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; tryptophan is synthesized from chorismate via anthranilate. IEA Catalysis of the reaction: chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate. IEA GO:0004049 anthranilate synthase activity GSVIVG01024770001 7107663 7113284 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate. IEA GO:0004049 anthranilate synthase activity GSVIVG01024770001 7107663 7113284 GO:0000162 tryptophan biosynthetic process The chemical reactions and pathways resulting in the formation of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; tryptophan is synthesized from chorismate via anthranilate. IEA Catalysis of the cleavage of a C-C bond by other means than by hydrolysis or oxidation, of a 3-hydroxy acid. IEA GO:0016833 oxo-acid-lyase activity GSVIVG01024770001 7107663 7113284 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the cleavage of a C-C bond by other means than by hydrolysis or oxidation, of a 3-hydroxy acid. IEA GO:0016833 oxo-acid-lyase activity GSVIVG01020766001 2258723 2263947 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01009401001 8000360 8000941 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01001892001 6863547 6866787 GSVIVG01016747001 875059 875474 GSVIVG01008680001 1159047 1167591 GSVIVG01005642001 20813965 20814280 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01038361001 13664672 13671835 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with transfer RNA. IEA GO:0000049 tRNA binding GSVIVG01038361001 13664672 13671835 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with transfer RNA. IEA GO:0000049 tRNA binding GSVIVG01038361001 13664672 13671835 GO:0006431 methionyl-tRNA aminoacylation The process of coupling methionine to methionyl-tRNA, catalyzed by methionyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with transfer RNA. IEA GO:0000049 tRNA binding GSVIVG01038361001 13664672 13671835 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01038361001 13664672 13671835 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01038361001 13664672 13671835 GO:0006431 methionyl-tRNA aminoacylation The process of coupling methionine to methionyl-tRNA, catalyzed by methionyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01038361001 13664672 13671835 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01038361001 13664672 13671835 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01038361001 13664672 13671835 GO:0006431 methionyl-tRNA aminoacylation The process of coupling methionine to methionyl-tRNA, catalyzed by methionyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01038361001 13664672 13671835 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met). IEA GO:0004825 methionine-tRNA ligase activity GSVIVG01038361001 13664672 13671835 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met). IEA GO:0004825 methionine-tRNA ligase activity GSVIVG01038361001 13664672 13671835 GO:0006431 methionyl-tRNA aminoacylation The process of coupling methionine to methionyl-tRNA, catalyzed by methionyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met). IEA GO:0004825 methionine-tRNA ligase activity GSVIVG01038361001 13664672 13671835 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038361001 13664672 13671835 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038361001 13664672 13671835 GO:0006431 methionyl-tRNA aminoacylation The process of coupling methionine to methionyl-tRNA, catalyzed by methionyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011404001 29379140 29380290 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0016272 prefoldin complex A multisubunit chaperone that acts to delivers unfolded proteins to cytosolic chaperonin. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01023666001 8738808 8742130 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01023666001 8738808 8742130 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01023666001 8738808 8742130 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01023666001 8738808 8742130 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023666001 8738808 8742130 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027159001 17356948 17358504 GO:0006777 Mo-molybdopterin cofactor biosynthetic process The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands. IEA GSVIVG01002260001 33755782 33757419 GSVIVG01013938001 7085322 7130414 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005945 6-phosphofructokinase complex A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known. IEA Catalysis of the reaction: ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate. IEA GO:0003872 6-phosphofructokinase activity GSVIVG01013938001 7085322 7130414 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005945 6-phosphofructokinase complex A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013307001 11524149 11528675 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01013307001 11524149 11528675 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01013307001 11524149 11528675 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013307001 11524149 11528675 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013307001 11524149 11528675 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013307001 11524149 11528675 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013307001 11524149 11528675 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01013307001 11524149 11528675 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01024404001 2156928 2157221 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01024404001 2156928 2157221 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01024404001 2156928 2157221 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with 5S ribosomal RNA, the smallest RNA constituent of a ribosome. IEA GO:0008097 5S rRNA binding GSVIVG01024404001 2156928 2157221 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with 5S ribosomal RNA, the smallest RNA constituent of a ribosome. IEA GO:0008097 5S rRNA binding GSVIVG01025463001 655062 660171 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01025463001 655062 660171 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01025463001 655062 660171 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01025463001 655062 660171 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01025463001 655062 660171 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025463001 655062 660171 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025463001 655062 660171 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025463001 655062 660171 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01007284001 31282108 31285725 GSVIVG01005996001 24310704 24315919 GSVIVG01036041001 7748236 7749085 GSVIVG01034360001 17432817 17439193 GSVIVG01014124001 580768 594553 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014124001 580768 594553 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014124001 580768 594553 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014124001 580768 594553 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033396001 20968837 20974641 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01033396001 20968837 20974641 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01033396001 20968837 20974641 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033396001 20968837 20974641 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01033396001 20968837 20974641 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01009887001 12137126 12140552 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: S-adenosyl-L-methionine + 2-(3-carboxy-3-aminopropyl)-L-histidine = S-adenosyl-L-homocysteine + 2-(3-carboxy-3-(methylammonio)propyl)-L-histidine. IEA GO:0004164 diphthine synthase activity GSVIVG01009887001 12137126 12140552 GO:0017183 peptidyl-diphthamide biosynthetic process from peptidyl-histidine The posttranslational modification of peptidyl-histidine to 2'-(3-carboxamido-3-(trimethylammonio)propyl)-L-histidine, known as diphthamide, found in translation elongation factor eEF-2. IEA Catalysis of the reaction: S-adenosyl-L-methionine + 2-(3-carboxy-3-aminopropyl)-L-histidine = S-adenosyl-L-homocysteine + 2-(3-carboxy-3-(methylammonio)propyl)-L-histidine. IEA GO:0004164 diphthine synthase activity GSVIVG01009887001 12137126 12140552 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01009887001 12137126 12140552 GO:0017183 peptidyl-diphthamide biosynthetic process from peptidyl-histidine The posttranslational modification of peptidyl-histidine to 2'-(3-carboxamido-3-(trimethylammonio)propyl)-L-histidine, known as diphthamide, found in translation elongation factor eEF-2. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01028138001 4100048 4104802 GSVIVG01021215001 2619160 2619803 GSVIVG01025188001 3578646 3580306 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01025188001 3578646 3580306 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01025188001 3578646 3580306 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01025188001 3578646 3580306 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01021507001 6374536 6376589 GSVIVG01023015001 16873137 16901630 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023015001 16873137 16901630 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023015001 16873137 16901630 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023015001 16873137 16901630 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023015001 16873137 16901630 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023015001 16873137 16901630 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023015001 16873137 16901630 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01023015001 16873137 16901630 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01013725001 8176319 8182598 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013725001 8176319 8182598 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030130 clathrin coat of trans-Golgi network vesicle A clathrin coat found on a vesicle of the trans-Golgi network. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013725001 8176319 8182598 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013725001 8176319 8182598 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013725001 8176319 8182598 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030130 clathrin coat of trans-Golgi network vesicle A clathrin coat found on a vesicle of the trans-Golgi network. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013725001 8176319 8182598 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013725001 8176319 8182598 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013725001 8176319 8182598 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030130 clathrin coat of trans-Golgi network vesicle A clathrin coat found on a vesicle of the trans-Golgi network. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013725001 8176319 8182598 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013725001 8176319 8182598 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013725001 8176319 8182598 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030130 clathrin coat of trans-Golgi network vesicle A clathrin coat found on a vesicle of the trans-Golgi network. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013725001 8176319 8182598 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013725001 8176319 8182598 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01013725001 8176319 8182598 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030130 clathrin coat of trans-Golgi network vesicle A clathrin coat found on a vesicle of the trans-Golgi network. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01013725001 8176319 8182598 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01013725001 8176319 8182598 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01013725001 8176319 8182598 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030130 clathrin coat of trans-Golgi network vesicle A clathrin coat found on a vesicle of the trans-Golgi network. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01013725001 8176319 8182598 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01013725001 8176319 8182598 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01013725001 8176319 8182598 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030130 clathrin coat of trans-Golgi network vesicle A clathrin coat found on a vesicle of the trans-Golgi network. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01013725001 8176319 8182598 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01013725001 8176319 8182598 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01013725001 8176319 8182598 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030130 clathrin coat of trans-Golgi network vesicle A clathrin coat found on a vesicle of the trans-Golgi network. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01013725001 8176319 8182598 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01012697001 780520 787296 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01012697001 780520 787296 GO:0008037 cell recognition The process by which a cell in a multicellular organism interprets its surroundings. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01012697001 780520 787296 GO:0019058 viral infectious cycle A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01012697001 780520 787296 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012697001 780520 787296 GO:0008037 cell recognition The process by which a cell in a multicellular organism interprets its surroundings. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012697001 780520 787296 GO:0019058 viral infectious cycle A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012697001 780520 787296 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01012697001 780520 787296 GO:0008037 cell recognition The process by which a cell in a multicellular organism interprets its surroundings. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01012697001 780520 787296 GO:0019058 viral infectious cycle A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01012697001 780520 787296 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012697001 780520 787296 GO:0008037 cell recognition The process by which a cell in a multicellular organism interprets its surroundings. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012697001 780520 787296 GO:0019058 viral infectious cycle A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012697001 780520 787296 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012697001 780520 787296 GO:0008037 cell recognition The process by which a cell in a multicellular organism interprets its surroundings. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012697001 780520 787296 GO:0019058 viral infectious cycle A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012697001 780520 787296 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01012697001 780520 787296 GO:0008037 cell recognition The process by which a cell in a multicellular organism interprets its surroundings. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01012697001 780520 787296 GO:0019058 viral infectious cycle A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01004816001 140147 140836 GSVIVG01006042001 23429719 23438412 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01011641001 5664023 5665940 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01027422001 16867548 16876326 GO:0042254 ribosome biogenesis The process of the formation of the constituents of the ribosome subunits, their assembly, and their transport to the sites of protein synthesis. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01006517001 42718453 42719665 GSVIVG01021979001 4786421 4803928 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021979001 4786421 4803928 GO:0009073 aromatic amino acid family biosynthetic process The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021979001 4786421 4803928 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021979001 4786421 4803928 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: 3-dehydroquinate = 3-dehydroshikimate + H2O. IEA GO:0003855 3-dehydroquinate dehydratase activity GSVIVG01021979001 4786421 4803928 GO:0009073 aromatic amino acid family biosynthetic process The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: 3-dehydroquinate = 3-dehydroshikimate + H2O. IEA GO:0003855 3-dehydroquinate dehydratase activity GSVIVG01021979001 4786421 4803928 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: 3-dehydroquinate = 3-dehydroshikimate + H2O. IEA GO:0003855 3-dehydroquinate dehydratase activity GSVIVG01021979001 4786421 4803928 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: shikimate + NADP+ = 5-dehydroshikimate + NADPH + H+. IEA GO:0004764 shikimate 5-dehydrogenase activity GSVIVG01021979001 4786421 4803928 GO:0009073 aromatic amino acid family biosynthetic process The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: shikimate + NADP+ = 5-dehydroshikimate + NADPH + H+. IEA GO:0004764 shikimate 5-dehydrogenase activity GSVIVG01021979001 4786421 4803928 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: shikimate + NADP+ = 5-dehydroshikimate + NADPH + H+. IEA GO:0004764 shikimate 5-dehydrogenase activity GSVIVG01021979001 4786421 4803928 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01021979001 4786421 4803928 GO:0009073 aromatic amino acid family biosynthetic process The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01021979001 4786421 4803928 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01021979001 4786421 4803928 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01021979001 4786421 4803928 GO:0009073 aromatic amino acid family biosynthetic process The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01021979001 4786421 4803928 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01008540001 998659 1003556 GSVIVG01018987001 18049833 18052659 GSVIVG01003731001 7470447 7473633 GO:0006071 glycerol metabolic process The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. IEA Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. IEA GO:0008081 phosphoric diester hydrolase activity GSVIVG01003731001 7470447 7473633 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. IEA GO:0008081 phosphoric diester hydrolase activity GSVIVG01003731001 7470447 7473633 GO:0006071 glycerol metabolic process The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. IEA Catalysis of the reaction: a glycerophosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate. IEA GO:0008889 glycerophosphodiester phosphodiesterase activity GSVIVG01003731001 7470447 7473633 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: a glycerophosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate. IEA GO:0008889 glycerophosphodiester phosphodiesterase activity GSVIVG01020676001 3188597 3189752 GO:0009060 aerobic respiration The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01020676001 3188597 3189752 GO:0009060 aerobic respiration The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01020676001 3188597 3189752 GO:0009060 aerobic respiration The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01031611001 18915857 18918978 GO:0006278 RNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01031611001 18915857 18918978 GO:0006278 RNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. IEA Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time. IEA GO:0003964 RNA-directed DNA polymerase activity GSVIVG01022282001 18172519 18183958 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01022282001 18172519 18183958 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01033713001 18396651 18401473 GSVIVG01018391001 9864435 9865073 GSVIVG01036585001 18624436 18644576 GSVIVG01031593001 18634353 18636084 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01031593001 18634353 18636084 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01031593001 18634353 18636084 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01031593001 18634353 18636084 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01031593001 18634353 18636084 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01031593001 18634353 18636084 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01031593001 18634353 18636084 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01031593001 18634353 18636084 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01012569001 3737388 3747757 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012569001 3737388 3747757 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01000586001 6819902 6830379 GO:0008202 steroid metabolic process The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. IEA GSVIVG01028495001 8424354 8424874 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01028495001 8424354 8424874 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01016812001 1607086 1616117 GO:0006090 pyruvate metabolic process The chemical reactions and pathways involving pyruvate, 2-oxopropanoate. IEA GO:0045254 pyruvate dehydrogenase complex Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). IEA Catalysis of the reaction: acetyl-CoA + dihydrolipoamide = CoA + S-acetyldihydrolipoamide. IEA GO:0004742 dihydrolipoyllysine-residue acetyltransferase activity GSVIVG01016812001 1607086 1616117 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0045254 pyruvate dehydrogenase complex Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). IEA Catalysis of the reaction: acetyl-CoA + dihydrolipoamide = CoA + S-acetyldihydrolipoamide. IEA GO:0004742 dihydrolipoyllysine-residue acetyltransferase activity GSVIVG01016812001 1607086 1616117 GO:0006090 pyruvate metabolic process The chemical reactions and pathways involving pyruvate, 2-oxopropanoate. IEA GO:0045254 pyruvate dehydrogenase complex Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016812001 1607086 1616117 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0045254 pyruvate dehydrogenase complex Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016812001 1607086 1616117 GO:0006090 pyruvate metabolic process The chemical reactions and pathways involving pyruvate, 2-oxopropanoate. IEA GO:0045254 pyruvate dehydrogenase complex Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01016812001 1607086 1616117 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0045254 pyruvate dehydrogenase complex Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01016712001 545784 553356 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016712001 545784 553356 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016712001 545784 553356 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0010181 FMN binding GSVIVG01016712001 545784 553356 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0010181 FMN binding GSVIVG01016712001 545784 553356 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016712001 545784 553356 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01035264001 11610028 11613129 GSVIVG01034962001 480374 483103 GSVIVG01037264001 16747990 16758021 GSVIVG01019926001 4503160 4504290 GSVIVG01018870001 19071628 19073234 GSVIVG01024786001 6952533 6953717 GSVIVG01037389001 14554927 14557005 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01037389001 14554927 14557005 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01037389001 14554927 14557005 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Stops, prevents or reduces the activity of a cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004869 cysteine-type endopeptidase inhibitor activity GSVIVG01037389001 14554927 14557005 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Stops, prevents or reduces the activity of a cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004869 cysteine-type endopeptidase inhibitor activity GSVIVG01037389001 14554927 14557005 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds. IEA GO:0030414 peptidase inhibitor activity GSVIVG01037389001 14554927 14557005 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds. IEA GO:0030414 peptidase inhibitor activity GSVIVG01020142001 9901187 9901852 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with manganese (Mn) ions. IEA GO:0030145 manganese ion binding GSVIVG01020142001 9901187 9901852 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Functions in the storage of nutritious substrates. IEA GO:0045735 nutrient reservoir activity GSVIVG01007643001 10885567 10892759 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01007643001 10885567 10892759 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007643001 10885567 10892759 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01020132001 10009736 10011362 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01020132001 10009736 10011362 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01020132001 10009736 10011362 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01029590001 21009303 21009566 GSVIVG01032644001 1858219 1891486 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01032644001 1858219 1891486 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01012727001 1056611 1058625 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01012727001 1056611 1058625 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01012727001 1056611 1058625 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01012727001 1056611 1058625 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01029103001 19680468 19699408 GSVIVG01030542001 6603020 6605858 GSVIVG01027048001 18369349 18374080 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01027048001 18369349 18374080 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01027048001 18369349 18374080 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01027048001 18369349 18374080 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01027048001 18369349 18374080 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01027048001 18369349 18374080 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01027048001 18369349 18374080 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027048001 18369349 18374080 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027048001 18369349 18374080 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027048001 18369349 18374080 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027048001 18369349 18374080 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027048001 18369349 18374080 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01015026001 548526 552513 GSVIVG01038713001 20694058 20700574 GSVIVG01002601001 35358383 35359101 GSVIVG01022611001 13348293 13349583 GSVIVG01005084001 14371355 14380046 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01033523001 20033257 20037327 GSVIVG01007571001 11874604 11876146 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01007571001 11874604 11876146 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01007571001 11874604 11876146 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008237 metallopeptidase activity GSVIVG01007571001 11874604 11876146 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01033680001 18736085 18739527 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01033680001 18736085 18739527 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01033680001 18736085 18739527 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01033680001 18736085 18739527 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01033680001 18736085 18739527 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01033680001 18736085 18739527 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033680001 18736085 18739527 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033680001 18736085 18739527 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033680001 18736085 18739527 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033680001 18736085 18739527 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033680001 18736085 18739527 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01033680001 18736085 18739527 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01033680001 18736085 18739527 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01033680001 18736085 18739527 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01033680001 18736085 18739527 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01021412001 5067575 5069538 GSVIVG01017847001 3998889 3999706 GSVIVG01034621001 14129019 14129868 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01031444001 18435705 18504776 GSVIVG01037225001 27722034 27730799 GSVIVG01013876001 5806566 5813044 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01030296001 9333762 9334888 GSVIVG01016265001 5760485 5763979 GSVIVG01018244001 12624314 12634770 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01025507001 227874 247289 GSVIVG01028764001 19098149 19102682 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01038768001 695266 697678 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01038768001 695266 697678 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01038768001 695266 697678 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01038768001 695266 697678 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01038768001 695266 697678 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015448001 3786102 3792770 GSVIVG01018323001 11091448 11096187 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01018323001 11091448 11096187 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01018323001 11091448 11096187 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01018323001 11091448 11096187 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01015435001 3655577 3666473 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015435001 3655577 3666473 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01015435001 3655577 3666473 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01017835001 3885149 3896071 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01000782001 91764 99645 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01000782001 91764 99645 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01014235001 1773645 1784539 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01014235001 1773645 1784539 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01014235001 1773645 1784539 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01014235001 1773645 1784539 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01014235001 1773645 1784539 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01014235001 1773645 1784539 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01014235001 1773645 1784539 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01014235001 1773645 1784539 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01014235001 1773645 1784539 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01014235001 1773645 1784539 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01014235001 1773645 1784539 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014235001 1773645 1784539 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014235001 1773645 1784539 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01014235001 1773645 1784539 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01014235001 1773645 1784539 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate. IEA GO:0019001 guanyl nucleotide binding GSVIVG01014235001 1773645 1784539 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate. IEA GO:0019001 guanyl nucleotide binding GSVIVG01005968001 23028234 23029456 GSVIVG01021221001 2706938 2707391 GSVIVG01033203001 9601201 9680561 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033203001 9601201 9680561 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008906001 3307440 3307550 GSVIVG01010593001 16225502 16227189 GSVIVG01031478001 18134332 18137443 GO:0045132 meiotic chromosome segregation The process by which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets during M phase of the meiotic cell cycle. IEA GO:0000775 chromosome, centromeric region The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome. IEA GSVIVG01031478001 18134332 18137443 GO:0045132 meiotic chromosome segregation The process by which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets during M phase of the meiotic cell cycle. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01004715001 15443807 15450589 GSVIVG01017185001 5115461 5134896 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01017185001 5115461 5134896 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017185001 5115461 5134896 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01017185001 5115461 5134896 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01021001001 15578599 15596564 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0005923 tight junction An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01021001001 15578599 15596564 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009539 photosystem II reaction center An integral membrane complex containing P680, the chlorophyll a molecule that functions as a primary electron donor. In the light, functioning as a water-plastoquinone oxidoreductase, it transfers electrons from water to plastoquinone. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01021001001 15578599 15596564 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01038363001 13684162 13686638 GSVIVG01034006001 15953990 15954208 GSVIVG01022299001 18323268 18327302 GSVIVG01036685001 23874564 23889349 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0009276 Gram-negative-bacterium-type cell wall The peptidoglycan layer of the Gram-negative cell envelope. In Gram-negative cells the peptidoglycan is relatively thin (1-2nm) and is linked to the outer membrane by lipoproteins. In Gram-negative cells the peptidoglycan is too thin to retain the primary stain in the Gram staining procedure and therefore cells appear red after Gram stain. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01036685001 23874564 23889349 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01036685001 23874564 23889349 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01036685001 23874564 23889349 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0009276 Gram-negative-bacterium-type cell wall The peptidoglycan layer of the Gram-negative cell envelope. In Gram-negative cells the peptidoglycan is relatively thin (1-2nm) and is linked to the outer membrane by lipoproteins. In Gram-negative cells the peptidoglycan is too thin to retain the primary stain in the Gram staining procedure and therefore cells appear red after Gram stain. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01036685001 23874564 23889349 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01036685001 23874564 23889349 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01036685001 23874564 23889349 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0009276 Gram-negative-bacterium-type cell wall The peptidoglycan layer of the Gram-negative cell envelope. In Gram-negative cells the peptidoglycan is relatively thin (1-2nm) and is linked to the outer membrane by lipoproteins. In Gram-negative cells the peptidoglycan is too thin to retain the primary stain in the Gram staining procedure and therefore cells appear red after Gram stain. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01036685001 23874564 23889349 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01036685001 23874564 23889349 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01036685001 23874564 23889349 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0009276 Gram-negative-bacterium-type cell wall The peptidoglycan layer of the Gram-negative cell envelope. In Gram-negative cells the peptidoglycan is relatively thin (1-2nm) and is linked to the outer membrane by lipoproteins. In Gram-negative cells the peptidoglycan is too thin to retain the primary stain in the Gram staining procedure and therefore cells appear red after Gram stain. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01036685001 23874564 23889349 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01036685001 23874564 23889349 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01036685001 23874564 23889349 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0009276 Gram-negative-bacterium-type cell wall The peptidoglycan layer of the Gram-negative cell envelope. In Gram-negative cells the peptidoglycan is relatively thin (1-2nm) and is linked to the outer membrane by lipoproteins. In Gram-negative cells the peptidoglycan is too thin to retain the primary stain in the Gram staining procedure and therefore cells appear red after Gram stain. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036685001 23874564 23889349 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036685001 23874564 23889349 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036685001 23874564 23889349 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0009276 Gram-negative-bacterium-type cell wall The peptidoglycan layer of the Gram-negative cell envelope. In Gram-negative cells the peptidoglycan is relatively thin (1-2nm) and is linked to the outer membrane by lipoproteins. In Gram-negative cells the peptidoglycan is too thin to retain the primary stain in the Gram staining procedure and therefore cells appear red after Gram stain. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036685001 23874564 23889349 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036685001 23874564 23889349 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036685001 23874564 23889349 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0009276 Gram-negative-bacterium-type cell wall The peptidoglycan layer of the Gram-negative cell envelope. In Gram-negative cells the peptidoglycan is relatively thin (1-2nm) and is linked to the outer membrane by lipoproteins. In Gram-negative cells the peptidoglycan is too thin to retain the primary stain in the Gram staining procedure and therefore cells appear red after Gram stain. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01036685001 23874564 23889349 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01036685001 23874564 23889349 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01036685001 23874564 23889349 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0009276 Gram-negative-bacterium-type cell wall The peptidoglycan layer of the Gram-negative cell envelope. In Gram-negative cells the peptidoglycan is relatively thin (1-2nm) and is linked to the outer membrane by lipoproteins. In Gram-negative cells the peptidoglycan is too thin to retain the primary stain in the Gram staining procedure and therefore cells appear red after Gram stain. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01036685001 23874564 23889349 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01036685001 23874564 23889349 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01036685001 23874564 23889349 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0009276 Gram-negative-bacterium-type cell wall The peptidoglycan layer of the Gram-negative cell envelope. In Gram-negative cells the peptidoglycan is relatively thin (1-2nm) and is linked to the outer membrane by lipoproteins. In Gram-negative cells the peptidoglycan is too thin to retain the primary stain in the Gram staining procedure and therefore cells appear red after Gram stain. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01036685001 23874564 23889349 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01036685001 23874564 23889349 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01036685001 23874564 23889349 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0009276 Gram-negative-bacterium-type cell wall The peptidoglycan layer of the Gram-negative cell envelope. In Gram-negative cells the peptidoglycan is relatively thin (1-2nm) and is linked to the outer membrane by lipoproteins. In Gram-negative cells the peptidoglycan is too thin to retain the primary stain in the Gram staining procedure and therefore cells appear red after Gram stain. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01036685001 23874564 23889349 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01036685001 23874564 23889349 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01036685001 23874564 23889349 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0009276 Gram-negative-bacterium-type cell wall The peptidoglycan layer of the Gram-negative cell envelope. In Gram-negative cells the peptidoglycan is relatively thin (1-2nm) and is linked to the outer membrane by lipoproteins. In Gram-negative cells the peptidoglycan is too thin to retain the primary stain in the Gram staining procedure and therefore cells appear red after Gram stain. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01036685001 23874564 23889349 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01036685001 23874564 23889349 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01036685001 23874564 23889349 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0009276 Gram-negative-bacterium-type cell wall The peptidoglycan layer of the Gram-negative cell envelope. In Gram-negative cells the peptidoglycan is relatively thin (1-2nm) and is linked to the outer membrane by lipoproteins. In Gram-negative cells the peptidoglycan is too thin to retain the primary stain in the Gram staining procedure and therefore cells appear red after Gram stain. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01036685001 23874564 23889349 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01036685001 23874564 23889349 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01010047001 13810562 13811785 GSVIVG01025432001 840646 846032 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025432001 840646 846032 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01006482001 26392513 26395378 GSVIVG01034557001 19496010 19497154 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. IEA GO:0004364 glutathione transferase activity GSVIVG01027894001 9142829 9143017 GSVIVG01000184001 15965561 15967356 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01000184001 15965561 15967356 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01000184001 15965561 15967356 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01000184001 15965561 15967356 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01038387001 11557441 11558052 GSVIVG01032429001 27313965 27318926 GSVIVG01033567001 19704974 19705910 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01000089001 3378829 3423078 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01011464001 29821976 29848627 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01020730001 2593115 2599450 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01020730001 2593115 2599450 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01020730001 2593115 2599450 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01020730001 2593115 2599450 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020730001 2593115 2599450 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031030001 21157325 21159059 GSVIVG01017102001 4169931 4173481 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01017102001 4169931 4173481 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01017102001 4169931 4173481 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01017102001 4169931 4173481 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01017102001 4169931 4173481 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01017102001 4169931 4173481 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017102001 4169931 4173481 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017102001 4169931 4173481 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017102001 4169931 4173481 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017102001 4169931 4173481 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017102001 4169931 4173481 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01017102001 4169931 4173481 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01017102001 4169931 4173481 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01017102001 4169931 4173481 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01017102001 4169931 4173481 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01036169001 19886585 19889185 GSVIVG01036291001 3436026 3437589 GSVIVG01008355001 2913010 2945668 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018742001 20279054 20280781 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01003314001 8966129 8967142 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01005701001 21379818 21380215 GSVIVG01020155001 9724651 9730239 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01034024001 15760471 15769268 GSVIVG01019629001 2079818 2091015 GSVIVG01022038001 3937023 3969457 GSVIVG01024539001 9045755 9046371 GSVIVG01025850001 11220311 11226165 GSVIVG01006875001 28765455 28776585 GSVIVG01015519001 4403914 4419218 GO:0006465 signal peptide processing The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01015519001 4403914 4419218 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01031483001 18080662 18084284 GSVIVG01027094001 17988199 17990082 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01027094001 17988199 17990082 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01024376001 1739958 1751175 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01024376001 1739958 1751175 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01024376001 1739958 1751175 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020749001 2365619 2372733 GSVIVG01012192001 667767 679204 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012192001 667767 679204 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01012192001 667767 679204 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01035692001 3375988 3377199 GSVIVG01010616001 15985693 15992248 GSVIVG01010952001 2703563 2715730 GSVIVG01012658001 396949 401516 GO:0008654 phospholipid biosynthetic process The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor). IEA GO:0016780 phosphotransferase activity, for other substituted phosphate groups GSVIVG01031020001 21028395 21030424 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01009148001 5517924 5535125 GSVIVG01001429001 20911101 20918232 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01001429001 20911101 20918232 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01001429001 20911101 20918232 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01001429001 20911101 20918232 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01001429001 20911101 20918232 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001429001 20911101 20918232 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001429001 20911101 20918232 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01001429001 20911101 20918232 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01011222001 9756340 9760163 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01026513001 22409270 22410748 GSVIVG01009866001 11933806 11936199 GSVIVG01033073001 25555823 25556029 GSVIVG01014149001 836783 845543 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014149001 836783 845543 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014149001 836783 845543 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014149001 836783 845543 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036004001 7009417 7013238 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01036004001 7009417 7013238 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01036004001 7009417 7013238 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01032257001 14109966 14126005 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032257001 14109966 14126005 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032257001 14109966 14126005 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with biotin (cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid), the (+) enantiomer of which is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions. IEA GO:0009374 biotin binding GSVIVG01032257001 14109966 14126005 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01017189001 5183266 5183864 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01014122001 559937 564311 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA GSVIVG01000689001 15603207 15604930 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01000689001 15603207 15604930 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01017965001 5119010 5120096 GSVIVG01017719001 2881364 2896617 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01017719001 2881364 2896617 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01017719001 2881364 2896617 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017719001 2881364 2896617 Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01019167001 4417318 4417578 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01019167001 4417318 4417578 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01029085001 12193113 12218103 GSVIVG01015993001 16937387 16944695 GSVIVG01030050001 9192678 9195576 GSVIVG01008961001 3875300 3878509 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01008961001 3875300 3878509 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01008961001 3875300 3878509 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01008961001 3875300 3878509 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01001592001 18136888 18146114 GSVIVG01037531001 11990844 12030854 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin. IEA GO:0004221 ubiquitin thiolesterase activity GSVIVG01034669001 7422104 7438933 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: 3-alpha(S)-strictosidine = tryptamine + secologanin. IEA GO:0016844 strictosidine synthase activity GSVIVG01018204001 13256865 13259160 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01014439001 3777346 3779258 GO:0009765 photosynthesis, light harvesting Absorption and transfer of the energy absorbed from light photons between photosystem reaction centers. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA GSVIVG01014439001 3777346 3779258 GO:0009765 photosynthesis, light harvesting Absorption and transfer of the energy absorbed from light photons between photosystem reaction centers. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01014338001 2770459 2777826 GSVIVG01027435001 16737114 16738625 GSVIVG01007186001 30708208 30709345 GSVIVG01037642001 6485717 6495683 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01037642001 6485717 6495683 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026485001 22840754 22842681 GSVIVG01019479001 978400 986946 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid. IEA GO:0008378 galactosyltransferase activity GSVIVG01028119001 3966219 3978388 GSVIVG01010636001 15728828 15731417 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01010636001 15728828 15731417 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01010636001 15728828 15731417 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01010636001 15728828 15731417 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01010636001 15728828 15731417 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018085001 6344964 6348222 GSVIVG01030655001 13031950 13033969 GSVIVG01036642001 19595889 19640891 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01036642001 19595889 19640891 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01036642001 19595889 19640891 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a ribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to ribose. IEA GO:0032549 ribonucleoside binding GSVIVG01029567001 21457323 21457844 GSVIVG01025336001 1896279 1904113 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01025336001 1896279 1904113 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025336001 1896279 1904113 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. IEA GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity GSVIVG01025336001 1896279 1904113 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037382001 14652722 14664811 GO:0006566 threonine metabolic process The chemical reactions and pathways involving threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins. IEA Catalysis of the reaction: ATP + L-homoserine = ADP + O-phospho-L-homoserine. IEA GO:0004413 homoserine kinase activity GSVIVG01037382001 14652722 14664811 GO:0016114 terpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure. IEA Catalysis of the reaction: ATP + L-homoserine = ADP + O-phospho-L-homoserine. IEA GO:0004413 homoserine kinase activity GSVIVG01037382001 14652722 14664811 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA Catalysis of the reaction: ATP + L-homoserine = ADP + O-phospho-L-homoserine. IEA GO:0004413 homoserine kinase activity GSVIVG01037382001 14652722 14664811 GO:0006566 threonine metabolic process The chemical reactions and pathways involving threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037382001 14652722 14664811 GO:0016114 terpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037382001 14652722 14664811 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037382001 14652722 14664811 GO:0006566 threonine metabolic process The chemical reactions and pathways involving threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01037382001 14652722 14664811 GO:0016114 terpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01037382001 14652722 14664811 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01037382001 14652722 14664811 GO:0006566 threonine metabolic process The chemical reactions and pathways involving threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins. IEA Catalysis of the reaction: ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol. IEA GO:0050515 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity GSVIVG01037382001 14652722 14664811 GO:0016114 terpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure. IEA Catalysis of the reaction: ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol. IEA GO:0050515 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity GSVIVG01037382001 14652722 14664811 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA Catalysis of the reaction: ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol. IEA GO:0050515 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity GSVIVG01021807001 7113338 7123440 GSVIVG01031168001 1553093 1556079 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01031168001 1553093 1556079 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01009065001 4652460 4653650 GSVIVG01022323001 18488335 18500876 GSVIVG01000349001 11875119 11877082 GSVIVG01023549001 9813547 9813762 GSVIVG01019805001 3480175 3487061 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01035956001 6434196 6447365 Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum. IEA GO:0003993 acid phosphatase activity GSVIVG01035956001 6434196 6447365 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01035956001 6434196 6447365 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01026340001 14291918 14374501 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026830001 20121757 20125374 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026830001 20121757 20125374 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026830001 20121757 20125374 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026830001 20121757 20125374 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01026830001 20121757 20125374 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01026830001 20121757 20125374 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01026830001 20121757 20125374 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026830001 20121757 20125374 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026830001 20121757 20125374 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026830001 20121757 20125374 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01026830001 20121757 20125374 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01026830001 20121757 20125374 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01026830001 20121757 20125374 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01026830001 20121757 20125374 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01026830001 20121757 20125374 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01019594001 1820996 1826505 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005838 proteasome regulatory particle A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex recognizes and unfolds ubiquitinated proteins, and translocates them to the proteasome core complex. IEA GSVIVG01037733001 7342464 7347760 Interacting selectively and non-covalently with a lipid. IEA GO:0008289 lipid binding GSVIVG01027732001 7315631 7319091 GSVIVG01037049001 8375211 8376359 GSVIVG01038373001 11279100 11290329 GO:0001682 tRNA 5'-leader removal Generation of the mature 5'-end of the tRNA, usually via an endonucleolytic cleavage by RNase P. IEA Catalysis of the endonucleolytic cleavage of RNA, removing 5' extra nucleotides from tRNA precursor. IEA GO:0004526 ribonuclease P activity GSVIVG01036315001 3717755 3720275 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01036315001 3717755 3720275 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01007721001 9922870 9924825 GSVIVG01023887001 2660982 2661950 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01012469001 1289735 1295855 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function that links a sequence-specific transcription factor to the core RNA polymerase II complex but does not bind DNA itself. IEA GO:0003712 transcription cofactor activity GSVIVG01012469001 1289735 1295855 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025264001 2604318 2604473 GSVIVG01024753001 7208305 7210321 GSVIVG01008396001 2505973 2509710 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01008396001 2505973 2509710 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01008396001 2505973 2509710 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01008396001 2505973 2509710 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01036861001 18609441 18617224 GSVIVG01009915001 12341546 12342790 GSVIVG01022867001 18573041 18645328 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA Catalysis of the addition of UDP-glucose on to asparagine-linked (N-linked) oligosaccharides of the form Man7-9GlcNAc2 on incorrectly folded glycoproteins. IEA GO:0003980 UDP-glucose:glycoprotein glucosyltransferase activity GSVIVG01022867001 18573041 18645328 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01024702001 7620854 7623490 Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01024702001 7620854 7623490 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024702001 7620854 7623490 Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. IEA GO:0016831 carboxy-lyase activity GSVIVG01024702001 7620854 7623490 Interacting selectively and non-covalently with thiamin pyrophosphate, the diphosphoric ester of thiamin. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases. IEA GO:0030976 thiamin pyrophosphate binding GSVIVG01024738001 7337480 7343092 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). IEA GO:0003755 peptidyl-prolyl cis-trans isomerase activity GSVIVG01024738001 7337480 7343092 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. IEA GO:0016853 isomerase activity GSVIVG01016844001 1878972 1883679 GSVIVG01026782001 7079019 7088278 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026782001 7079019 7088278 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a phosphate group (acceptor). IEA GO:0016776 phosphotransferase activity, phosphate group as acceptor GSVIVG01026782001 7079019 7088278 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Catalysis of the reaction: ATP + nucleoside monophosphate = ADP + nucleoside diphosphate. IEA GO:0019201 nucleotide kinase activity GSVIVG01026782001 7079019 7088278 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate. IEA GO:0019205 nucleobase, nucleoside, nucleotide kinase activity GSVIVG01003372001 9478510 9479415 Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01001299001 5141540 5142274 GO:0006869 lipid transport The directed movement of lipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GSVIVG01012604001 4541369 4545003 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012604001 4541369 4545003 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01012604001 4541369 4545003 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01034470001 20806774 20807814 GSVIVG01011986001 2402402 2404621 GSVIVG01036287001 3394259 3398610 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01036287001 3394259 3398610 GO:0006427 histidyl-tRNA aminoacylation The process of coupling histidine to histidyl-tRNA, catalyzed by histidyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01036287001 3394259 3398610 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01036287001 3394259 3398610 GO:0006427 histidyl-tRNA aminoacylation The process of coupling histidine to histidyl-tRNA, catalyzed by histidyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01036287001 3394259 3398610 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His). IEA GO:0004821 histidine-tRNA ligase activity GSVIVG01036287001 3394259 3398610 GO:0006427 histidyl-tRNA aminoacylation The process of coupling histidine to histidyl-tRNA, catalyzed by histidyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His). IEA GO:0004821 histidine-tRNA ligase activity GSVIVG01036287001 3394259 3398610 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036287001 3394259 3398610 GO:0006427 histidyl-tRNA aminoacylation The process of coupling histidine to histidyl-tRNA, catalyzed by histidyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009624001 10013441 10015072 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009654 oxygen evolving complex A complex, composed of a cluster of manganese, calcium and chloride ions bound to extrinsic proteins, that catalyzes the splitting of water to O2 and 4 H+. In cyanobacteria there are five extrinsic proteins in OEC (PsbO, PsbP-like, PsbQ-like, PsbU and PsbV), while in plants there are only three (PsbO, PsbP and PsbQ). IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01009624001 10013441 10015072 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0019898 extrinsic to membrane Loosely bound to one surface of a membrane, but not integrated into the hydrophobic region. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01009624001 10013441 10015072 GO:0042549 photosystem II stabilization The stabilization of the photosystem II protein complex, resulting from the phosphorylation of its structural protein subunits, in a cell actively involved in photosynthesis. IEA GO:0009654 oxygen evolving complex A complex, composed of a cluster of manganese, calcium and chloride ions bound to extrinsic proteins, that catalyzes the splitting of water to O2 and 4 H+. In cyanobacteria there are five extrinsic proteins in OEC (PsbO, PsbP-like, PsbQ-like, PsbU and PsbV), while in plants there are only three (PsbO, PsbP and PsbQ). IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01009624001 10013441 10015072 GO:0042549 photosystem II stabilization The stabilization of the photosystem II protein complex, resulting from the phosphorylation of its structural protein subunits, in a cell actively involved in photosynthesis. IEA GO:0019898 extrinsic to membrane Loosely bound to one surface of a membrane, but not integrated into the hydrophobic region. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01006366001 25290174 25290525 GSVIVG01001847001 26280562 26289889 GO:0006006 glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001847001 26280562 26289889 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001847001 26280562 26289889 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001847001 26280562 26289889 GO:0006006 glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. IEA Catalysis of the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+. IEA GO:0004345 glucose-6-phosphate dehydrogenase activity GSVIVG01001847001 26280562 26289889 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+. IEA GO:0004345 glucose-6-phosphate dehydrogenase activity GSVIVG01001847001 26280562 26289889 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+. IEA GO:0004345 glucose-6-phosphate dehydrogenase activity GSVIVG01001847001 26280562 26289889 GO:0006006 glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01001847001 26280562 26289889 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01001847001 26280562 26289889 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008542001 979962 990944 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008542001 979962 990944 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01008542001 979962 990944 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031981001 5887915 5897060 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031981001 5887915 5897060 GO:0006284 base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009554001 9346636 9349824 GO:0006788 heme oxidation The chemical reactions and pathways resulting in the loss of electrons from one or more atoms in heme. IEA Catalysis of the reaction: heme + 3 donor-H2 + 3 O2 = biliverdin + Fe2+ + CO + 3 acceptor + 3 H2O. IEA GO:0004392 heme oxygenase (decyclizing) activity GSVIVG01009554001 9346636 9349824 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: heme + 3 donor-H2 + 3 O2 = biliverdin + Fe2+ + CO + 3 acceptor + 3 H2O. IEA GO:0004392 heme oxygenase (decyclizing) activity GSVIVG01015968001 16411904 16412176 GSVIVG01020820001 1564982 1577904 GSVIVG01028586001 10257925 10262286 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028586001 10257925 10262286 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01028586001 10257925 10262286 Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01024469001 3049672 3055046 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0009707 chloroplast outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the chloroplast envelope. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01024469001 3049672 3055046 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0009707 chloroplast outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the chloroplast envelope. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01024198001 398627 406803 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01024198001 398627 406803 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01024198001 398627 406803 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01024198001 398627 406803 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01009515001 8992931 9000398 GSVIVG01001260001 4868643 4878641 GSVIVG01024260001 316837 332542 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01024260001 316837 332542 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01024260001 316837 332542 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01024260001 316837 332542 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035878001 5180509 5200603 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01035878001 5180509 5200603 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01020287001 21873123 21873615 GSVIVG01032833001 379318 381546 GSVIVG01011019001 2170107 2178966 GSVIVG01034959001 454099 454377 GSVIVG01002826001 36829371 36835373 GSVIVG01011437001 29649247 29650896 GO:0009664 plant-type cell wall organization A process that results in the assembly and arrangement of constituent parts of the cellulose and pectin-containing cell wall, or in the disassembly of the cellulose and pectin-containing cell wall. This process is carried out at the cellular level. An example of this process is found in Arabidopsis thaliana. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA GSVIVG01011437001 29649247 29650896 GO:0009664 plant-type cell wall organization A process that results in the assembly and arrangement of constituent parts of the cellulose and pectin-containing cell wall, or in the disassembly of the cellulose and pectin-containing cell wall. This process is carried out at the cellular level. An example of this process is found in Arabidopsis thaliana. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01019077001 16994789 17002116 GO:0009231 riboflavin biosynthetic process The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019077001 16994789 17002116 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019077001 16994789 17002116 GO:0009231 riboflavin biosynthetic process The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01019077001 16994789 17002116 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01019077001 16994789 17002116 GO:0009231 riboflavin biosynthetic process The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). IEA Catalysis of the reaction: 5-amino-6-(5-phosphoribitylamino)uracil + NADP+ = 5-amino-6-(5-phosphoribosylamino)uracil + NADPH + H+. IEA GO:0008703 5-amino-6-(5-phosphoribosylamino)uracil reductase activity GSVIVG01019077001 16994789 17002116 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 5-amino-6-(5-phosphoribitylamino)uracil + NADP+ = 5-amino-6-(5-phosphoribosylamino)uracil + NADPH + H+. IEA GO:0008703 5-amino-6-(5-phosphoribosylamino)uracil reductase activity GSVIVG01019077001 16994789 17002116 GO:0009231 riboflavin biosynthetic process The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). IEA Catalysis of the reaction: 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine + H2O = 5-amino-6-(5-phosphoribosylamino)uracil + NH3. IEA GO:0008835 diaminohydroxyphosphoribosylaminopyrimidine deaminase activity GSVIVG01019077001 16994789 17002116 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine + H2O = 5-amino-6-(5-phosphoribosylamino)uracil + NH3. IEA GO:0008835 diaminohydroxyphosphoribosylaminopyrimidine deaminase activity GSVIVG01019077001 16994789 17002116 GO:0009231 riboflavin biosynthetic process The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01019077001 16994789 17002116 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01019077001 16994789 17002116 GO:0009231 riboflavin biosynthetic process The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01019077001 16994789 17002116 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01028042001 3376196 3378852 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028042001 3376196 3378852 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01030201001 10534425 10550169 GSVIVG01024394001 2061535 2064364 GSVIVG01005715001 21540905 21541494 GSVIVG01009532001 9114292 9114769 GSVIVG01021146001 1822680 1826872 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01021146001 1822680 1826872 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01001334001 315576 320320 GO:0032955 regulation of barrier septum formation Any process that modulates the frequency, rate or extent of barrier septum formation. Barrier septum formation is the assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. IEA GSVIVG01001334001 315576 320320 GO:0051301 cell division The process resulting in the physical partitioning and separation of a cell into daughter cells. IEA GSVIVG01016806001 1552173 1558875 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01016806001 1552173 1558875 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01016806001 1552173 1558875 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01016806001 1552173 1558875 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01016806001 1552173 1558875 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01016806001 1552173 1558875 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01016806001 1552173 1558875 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016806001 1552173 1558875 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016806001 1552173 1558875 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016806001 1552173 1558875 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016806001 1552173 1558875 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016806001 1552173 1558875 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016806001 1552173 1558875 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the movement of phospholipids from one membrane face to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP. IEA GO:0004012 phospholipid-translocating ATPase activity GSVIVG01016806001 1552173 1558875 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the movement of phospholipids from one membrane face to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP. IEA GO:0004012 phospholipid-translocating ATPase activity GSVIVG01016806001 1552173 1558875 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the movement of phospholipids from one membrane face to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP. IEA GO:0004012 phospholipid-translocating ATPase activity GSVIVG01016806001 1552173 1558875 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the movement of phospholipids from one membrane face to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP. IEA GO:0004012 phospholipid-translocating ATPase activity GSVIVG01016806001 1552173 1558875 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the movement of phospholipids from one membrane face to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP. IEA GO:0004012 phospholipid-translocating ATPase activity GSVIVG01016806001 1552173 1558875 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the movement of phospholipids from one membrane face to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP. IEA GO:0004012 phospholipid-translocating ATPase activity GSVIVG01016806001 1552173 1558875 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016806001 1552173 1558875 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016806001 1552173 1558875 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016806001 1552173 1558875 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016806001 1552173 1558875 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016806001 1552173 1558875 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016806001 1552173 1558875 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01016806001 1552173 1558875 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01016806001 1552173 1558875 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01016806001 1552173 1558875 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01016806001 1552173 1558875 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01016806001 1552173 1558875 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01016806001 1552173 1558875 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01016806001 1552173 1558875 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01016806001 1552173 1558875 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01016806001 1552173 1558875 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01016806001 1552173 1558875 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01016806001 1552173 1558875 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01016806001 1552173 1558875 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016806001 1552173 1558875 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016806001 1552173 1558875 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016806001 1552173 1558875 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016806001 1552173 1558875 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016806001 1552173 1558875 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01007468001 32066654 32067448 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01031712001 3664807 3668161 GSVIVG01029486001 22353921 22354162 GSVIVG01016898001 2380468 2381531 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GSVIVG01009159001 5651901 5652908 GSVIVG01018190001 13411980 13415839 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018190001 13411980 13415839 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018190001 13411980 13415839 GO:0006099 tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018190001 13411980 13415839 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018190001 13411980 13415839 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018190001 13411980 13415839 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018190001 13411980 13415839 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018190001 13411980 13415839 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01018190001 13411980 13415839 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01018190001 13411980 13415839 GO:0006099 tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01018190001 13411980 13415839 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01018190001 13411980 13415839 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01018190001 13411980 13415839 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01018190001 13411980 13415839 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01018190001 13411980 13415839 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01018190001 13411980 13415839 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01018190001 13411980 13415839 GO:0006099 tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01018190001 13411980 13415839 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01018190001 13411980 13415839 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01018190001 13411980 13415839 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01018190001 13411980 13415839 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01018190001 13411980 13415839 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. IEA GO:0016615 malate dehydrogenase activity GSVIVG01018190001 13411980 13415839 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. IEA GO:0016615 malate dehydrogenase activity GSVIVG01018190001 13411980 13415839 GO:0006099 tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. IEA Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. IEA GO:0016615 malate dehydrogenase activity GSVIVG01018190001 13411980 13415839 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. IEA GO:0016615 malate dehydrogenase activity GSVIVG01018190001 13411980 13415839 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. IEA GO:0016615 malate dehydrogenase activity GSVIVG01018190001 13411980 13415839 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. IEA GO:0016615 malate dehydrogenase activity GSVIVG01018190001 13411980 13415839 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. IEA GO:0016615 malate dehydrogenase activity GSVIVG01018190001 13411980 13415839 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01018190001 13411980 13415839 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01018190001 13411980 13415839 GO:0006099 tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01018190001 13411980 13415839 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01018190001 13411980 13415839 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01018190001 13411980 13415839 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01018190001 13411980 13415839 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01018190001 13411980 13415839 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids. IEA GO:0030060 L-malate dehydrogenase activity GSVIVG01018190001 13411980 13415839 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids. IEA GO:0030060 L-malate dehydrogenase activity GSVIVG01018190001 13411980 13415839 GO:0006099 tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. IEA Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids. IEA GO:0030060 L-malate dehydrogenase activity GSVIVG01018190001 13411980 13415839 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids. IEA GO:0030060 L-malate dehydrogenase activity GSVIVG01018190001 13411980 13415839 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids. IEA GO:0030060 L-malate dehydrogenase activity GSVIVG01018190001 13411980 13415839 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids. IEA GO:0030060 L-malate dehydrogenase activity GSVIVG01018190001 13411980 13415839 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids. IEA GO:0030060 L-malate dehydrogenase activity GSVIVG01024115001 976131 977121 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01013504001 1956755 1962026 GSVIVG01018584001 12843678 12844139 Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01018584001 12843678 12844139 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018584001 12843678 12844139 Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01018584001 12843678 12844139 Interacting selectively and non-covalently with thiamin pyrophosphate, the diphosphoric ester of thiamin. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases. IEA GO:0030976 thiamin pyrophosphate binding GSVIVG01033175001 8940024 8941073 GSVIVG01005696001 21332852 21334300 GSVIVG01029713001 13553488 13556697 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029518001 22025588 22026489 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029518001 22025588 22026489 Catalysis of the transfer of a functional group from one position to another within a single molecule. IEA GO:0016866 intramolecular transferase activity GSVIVG01021882001 6058919 6069352 GSVIVG01001211001 745291 757472 GSVIVG01023177001 21585359 21585781 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01006146001 42135478 42136996 GSVIVG01031793001 4422527 4423196 Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01031793001 4422527 4423196 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01008700001 1303910 1307352 GSVIVG01005129001 18414535 18418999 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01020041001 11234424 11239295 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01020041001 11234424 11239295 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01020041001 11234424 11239295 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01020041001 11234424 11239295 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038053001 17070455 17071827 GSVIVG01016500001 3355781 3356735 GSVIVG01014063001 30921 35512 GSVIVG01024345001 1232408 1252175 GSVIVG01035774001 4190725 4193303 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01035774001 4190725 4193303 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01035774001 4190725 4193303 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01035774001 4190725 4193303 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01007642001 10893491 10895941 GSVIVG01013607001 1230349 1242476 GSVIVG01012398001 467092 468273 GSVIVG01024168001 632523 639580 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GSVIVG01018318001 11164533 11164661 GSVIVG01030969001 20027904 20029159 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01030969001 20027904 20029159 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01022433001 2911300 2912260 GSVIVG01009919001 12377350 12378164 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). IEA GO:0003755 peptidyl-prolyl cis-trans isomerase activity GSVIVG01032474001 27740853 27744569 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01010812001 22907018 22908789 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01015069001 814149 817606 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01015069001 814149 817606 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01015069001 814149 817606 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01015069001 814149 817606 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01016041001 17778310 17780597 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016041001 17778310 17780597 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016041001 17778310 17780597 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01016041001 17778310 17780597 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01006925001 29089788 29121308 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01006925001 29089788 29121308 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01006925001 29089788 29121308 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006925001 29089788 29121308 Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01012712001 885216 888362 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide. IEA GO:0016671 oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor GSVIVG01012712001 885216 888362 GO:0019419 sulfate reduction The chemical reactions and pathways resulting in the reduction of sulfate to another sulfur-containing ion or compound such as hydrogen sulfide, adenosine-phosphosulfate (APS) or thiosulfate. IEA Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide. IEA GO:0016671 oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor GSVIVG01012712001 885216 888362 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide. IEA GO:0016671 oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor GSVIVG01012712001 885216 888362 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide. IEA GO:0016671 oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor GSVIVG01012712001 885216 888362 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01012712001 885216 888362 GO:0019419 sulfate reduction The chemical reactions and pathways resulting in the reduction of sulfate to another sulfur-containing ion or compound such as hydrogen sulfide, adenosine-phosphosulfate (APS) or thiosulfate. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01012712001 885216 888362 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01012712001 885216 888362 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01022234001 17729900 17733065 GSVIVG01008029001 6498770 6499583 GSVIVG01031502001 17871188 17873379 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01003368001 9458648 9459634 GSVIVG01009396001 7983438 7986889 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01037257001 16869884 16870081 GSVIVG01036779001 22672340 22673080 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01036779001 22672340 22673080 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01036779001 22672340 22673080 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01036779001 22672340 22673080 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01036779001 22672340 22673080 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01036779001 22672340 22673080 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01030554001 6698849 6699846 GSVIVG01001793001 3268995 3273760 GSVIVG01027088001 18023632 18024645 GO:0006869 lipid transport The directed movement of lipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Interacting selectively and non-covalently with a lipid. IEA GO:0008289 lipid binding GSVIVG01024055001 1468180 1469527 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01024055001 1468180 1469527 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035991001 6906030 6906329 Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01028814001 18473350 18474919 GSVIVG01001732001 604626 604823 GSVIVG01030371001 5060601 5063020 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01014038001 9575861 9637431 GO:0006869 lipid transport The directed movement of lipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of lipids into, out of, within or between cells. IEA GO:0005319 lipid transporter activity GSVIVG01032948001 24532101 24533135 GSVIVG01026793001 7317198 7319488 GSVIVG01016250001 5921513 5929378 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005945 6-phosphofructokinase complex A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known. IEA Catalysis of the reaction: ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate. IEA GO:0003872 6-phosphofructokinase activity GSVIVG01016250001 5921513 5929378 GO:0006166 purine ribonucleoside salvage Any process which produces a purine nucleoside from derivatives of it, without de novo synthesis. IEA GO:0005945 6-phosphofructokinase complex A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known. IEA Catalysis of the reaction: ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate. IEA GO:0003872 6-phosphofructokinase activity GSVIVG01016250001 5921513 5929378 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005945 6-phosphofructokinase complex A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known. IEA Catalysis of the reaction: ATP + adenosine = ADP + AMP. IEA GO:0004001 adenosine kinase activity GSVIVG01016250001 5921513 5929378 GO:0006166 purine ribonucleoside salvage Any process which produces a purine nucleoside from derivatives of it, without de novo synthesis. IEA GO:0005945 6-phosphofructokinase complex A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known. IEA Catalysis of the reaction: ATP + adenosine = ADP + AMP. IEA GO:0004001 adenosine kinase activity GSVIVG01019275001 2131628 2138727 GSVIVG01011609001 6017204 6018710 GSVIVG01018126001 6782085 6784040 GSVIVG01007639001 10948915 10954865 GSVIVG01001172001 1077522 1080236 GSVIVG01003794001 12774466 12774966 GSVIVG01005085001 14390670 14392515 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01018320001 11137265 11144760 GSVIVG01028752001 19180521 19191510 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028752001 19180521 19191510 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01028752001 19180521 19191510 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01028313001 6023811 6027631 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01028313001 6023811 6027631 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01006662001 27320064 27321660 GO:0009767 photosynthetic electron transport chain A process, occurring as part of photosynthesis, whereby light provides the energy for a series of electron carriers to operate together to transfer electrons and generate a transmembrane electrochemical gradient. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. IEA GO:0016168 chlorophyll binding GSVIVG01006662001 27320064 27321660 GO:0009767 photosynthetic electron transport chain A process, occurring as part of photosynthesis, whereby light provides the energy for a series of electron carriers to operate together to transfer electrons and generate a transmembrane electrochemical gradient. IEA GO:0009521 photosystem A complex located in a photosynthetic membrane that consists of a photoreaction center associated with accessory pigments and electron carriers. Examples of this component are found in Arabidopsis thaliana and in photosynthetic bacterial and archaeal species. IEA Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. IEA GO:0016168 chlorophyll binding GSVIVG01006662001 27320064 27321660 GO:0009767 photosynthetic electron transport chain A process, occurring as part of photosynthesis, whereby light provides the energy for a series of electron carriers to operate together to transfer electrons and generate a transmembrane electrochemical gradient. IEA GO:0009523 photosystem II A photosystem that contains a pheophytin-quinone reaction center with associated accessory pigments and electron carriers. In cyanobacteria and chloroplasts, in the presence of light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone, whereas other photosynthetic bacteria carry out anoxygenic photosynthesis and oxidize other compounds to re-reduce the photoreaction center. IEA Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. IEA GO:0016168 chlorophyll binding GSVIVG01006662001 27320064 27321660 GO:0009767 photosynthetic electron transport chain A process, occurring as part of photosynthesis, whereby light provides the energy for a series of electron carriers to operate together to transfer electrons and generate a transmembrane electrochemical gradient. IEA GO:0009535 chloroplast thylakoid membrane The pigmented membrane of a chloroplast thylakoid. An example of this component is found in Arabidopsis thaliana. IEA Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. IEA GO:0016168 chlorophyll binding GSVIVG01006662001 27320064 27321660 GO:0009767 photosynthetic electron transport chain A process, occurring as part of photosynthesis, whereby light provides the energy for a series of electron carriers to operate together to transfer electrons and generate a transmembrane electrochemical gradient. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. IEA GO:0016168 chlorophyll binding GSVIVG01006662001 27320064 27321660 GO:0009767 photosynthetic electron transport chain A process, occurring as part of photosynthesis, whereby light provides the energy for a series of electron carriers to operate together to transfer electrons and generate a transmembrane electrochemical gradient. IEA GO:0009579 thylakoid A membranous cellular structure that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the plasma membrane. In eukaryotes they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation. IEA Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. IEA GO:0016168 chlorophyll binding GSVIVG01006662001 27320064 27321660 GO:0009767 photosynthetic electron transport chain A process, occurring as part of photosynthesis, whereby light provides the energy for a series of electron carriers to operate together to transfer electrons and generate a transmembrane electrochemical gradient. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. IEA GO:0016168 chlorophyll binding GSVIVG01006662001 27320064 27321660 GO:0009767 photosynthetic electron transport chain A process, occurring as part of photosynthesis, whereby light provides the energy for a series of electron carriers to operate together to transfer electrons and generate a transmembrane electrochemical gradient. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. IEA GO:0016168 chlorophyll binding GSVIVG01006662001 27320064 27321660 GO:0009767 photosynthetic electron transport chain A process, occurring as part of photosynthesis, whereby light provides the energy for a series of electron carriers to operate together to transfer electrons and generate a transmembrane electrochemical gradient. IEA GO:0030076 light-harvesting complex A protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center. IEA Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. IEA GO:0016168 chlorophyll binding GSVIVG01006662001 27320064 27321660 GO:0009772 photosynthetic electron transport in photosystem II Electrons move from the primary electron acceptor (Quinone, Q) through a chain of electron transport molecules in the thylakoid membrane until they reach the ultimate electron acceptor of Photosystem II, which is plastocyanin (PC). The electron is then passed to the P700 chlorophyll a molecules of the reaction centre of photosystem I. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. IEA GO:0016168 chlorophyll binding GSVIVG01006662001 27320064 27321660 GO:0009772 photosynthetic electron transport in photosystem II Electrons move from the primary electron acceptor (Quinone, Q) through a chain of electron transport molecules in the thylakoid membrane until they reach the ultimate electron acceptor of Photosystem II, which is plastocyanin (PC). The electron is then passed to the P700 chlorophyll a molecules of the reaction centre of photosystem I. IEA GO:0009521 photosystem A complex located in a photosynthetic membrane that consists of a photoreaction center associated with accessory pigments and electron carriers. Examples of this component are found in Arabidopsis thaliana and in photosynthetic bacterial and archaeal species. IEA Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. IEA GO:0016168 chlorophyll binding GSVIVG01006662001 27320064 27321660 GO:0009772 photosynthetic electron transport in photosystem II Electrons move from the primary electron acceptor (Quinone, Q) through a chain of electron transport molecules in the thylakoid membrane until they reach the ultimate electron acceptor of Photosystem II, which is plastocyanin (PC). The electron is then passed to the P700 chlorophyll a molecules of the reaction centre of photosystem I. IEA GO:0009523 photosystem II A photosystem that contains a pheophytin-quinone reaction center with associated accessory pigments and electron carriers. In cyanobacteria and chloroplasts, in the presence of light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone, whereas other photosynthetic bacteria carry out anoxygenic photosynthesis and oxidize other compounds to re-reduce the photoreaction center. IEA Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. IEA GO:0016168 chlorophyll binding GSVIVG01006662001 27320064 27321660 GO:0009772 photosynthetic electron transport in photosystem II Electrons move from the primary electron acceptor (Quinone, Q) through a chain of electron transport molecules in the thylakoid membrane until they reach the ultimate electron acceptor of Photosystem II, which is plastocyanin (PC). The electron is then passed to the P700 chlorophyll a molecules of the reaction centre of photosystem I. IEA GO:0009535 chloroplast thylakoid membrane The pigmented membrane of a chloroplast thylakoid. An example of this component is found in Arabidopsis thaliana. IEA Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. IEA GO:0016168 chlorophyll binding GSVIVG01006662001 27320064 27321660 GO:0009772 photosynthetic electron transport in photosystem II Electrons move from the primary electron acceptor (Quinone, Q) through a chain of electron transport molecules in the thylakoid membrane until they reach the ultimate electron acceptor of Photosystem II, which is plastocyanin (PC). The electron is then passed to the P700 chlorophyll a molecules of the reaction centre of photosystem I. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. IEA GO:0016168 chlorophyll binding GSVIVG01006662001 27320064 27321660 GO:0009772 photosynthetic electron transport in photosystem II Electrons move from the primary electron acceptor (Quinone, Q) through a chain of electron transport molecules in the thylakoid membrane until they reach the ultimate electron acceptor of Photosystem II, which is plastocyanin (PC). The electron is then passed to the P700 chlorophyll a molecules of the reaction centre of photosystem I. IEA GO:0009579 thylakoid A membranous cellular structure that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the plasma membrane. In eukaryotes they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation. IEA Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. IEA GO:0016168 chlorophyll binding GSVIVG01006662001 27320064 27321660 GO:0009772 photosynthetic electron transport in photosystem II Electrons move from the primary electron acceptor (Quinone, Q) through a chain of electron transport molecules in the thylakoid membrane until they reach the ultimate electron acceptor of Photosystem II, which is plastocyanin (PC). The electron is then passed to the P700 chlorophyll a molecules of the reaction centre of photosystem I. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. IEA GO:0016168 chlorophyll binding GSVIVG01006662001 27320064 27321660 GO:0009772 photosynthetic electron transport in photosystem II Electrons move from the primary electron acceptor (Quinone, Q) through a chain of electron transport molecules in the thylakoid membrane until they reach the ultimate electron acceptor of Photosystem II, which is plastocyanin (PC). The electron is then passed to the P700 chlorophyll a molecules of the reaction centre of photosystem I. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. IEA GO:0016168 chlorophyll binding GSVIVG01006662001 27320064 27321660 GO:0009772 photosynthetic electron transport in photosystem II Electrons move from the primary electron acceptor (Quinone, Q) through a chain of electron transport molecules in the thylakoid membrane until they reach the ultimate electron acceptor of Photosystem II, which is plastocyanin (PC). The electron is then passed to the P700 chlorophyll a molecules of the reaction centre of photosystem I. IEA GO:0030076 light-harvesting complex A protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center. IEA Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. IEA GO:0016168 chlorophyll binding GSVIVG01006662001 27320064 27321660 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. IEA GO:0016168 chlorophyll binding GSVIVG01006662001 27320064 27321660 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009521 photosystem A complex located in a photosynthetic membrane that consists of a photoreaction center associated with accessory pigments and electron carriers. Examples of this component are found in Arabidopsis thaliana and in photosynthetic bacterial and archaeal species. IEA Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. IEA GO:0016168 chlorophyll binding GSVIVG01006662001 27320064 27321660 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009523 photosystem II A photosystem that contains a pheophytin-quinone reaction center with associated accessory pigments and electron carriers. In cyanobacteria and chloroplasts, in the presence of light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone, whereas other photosynthetic bacteria carry out anoxygenic photosynthesis and oxidize other compounds to re-reduce the photoreaction center. IEA Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. IEA GO:0016168 chlorophyll binding GSVIVG01006662001 27320064 27321660 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009535 chloroplast thylakoid membrane The pigmented membrane of a chloroplast thylakoid. An example of this component is found in Arabidopsis thaliana. IEA Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. IEA GO:0016168 chlorophyll binding GSVIVG01006662001 27320064 27321660 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. IEA GO:0016168 chlorophyll binding GSVIVG01006662001 27320064 27321660 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009579 thylakoid A membranous cellular structure that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the plasma membrane. In eukaryotes they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation. IEA Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. IEA GO:0016168 chlorophyll binding GSVIVG01006662001 27320064 27321660 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. IEA GO:0016168 chlorophyll binding GSVIVG01006662001 27320064 27321660 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. IEA GO:0016168 chlorophyll binding GSVIVG01006662001 27320064 27321660 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0030076 light-harvesting complex A protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center. IEA Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. IEA GO:0016168 chlorophyll binding GSVIVG01006662001 27320064 27321660 GO:0018298 protein-chromophore linkage The covalent or noncovalent linking of a chromophore to a protein. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. IEA GO:0016168 chlorophyll binding GSVIVG01006662001 27320064 27321660 GO:0018298 protein-chromophore linkage The covalent or noncovalent linking of a chromophore to a protein. IEA GO:0009521 photosystem A complex located in a photosynthetic membrane that consists of a photoreaction center associated with accessory pigments and electron carriers. Examples of this component are found in Arabidopsis thaliana and in photosynthetic bacterial and archaeal species. IEA Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. IEA GO:0016168 chlorophyll binding GSVIVG01006662001 27320064 27321660 GO:0018298 protein-chromophore linkage The covalent or noncovalent linking of a chromophore to a protein. IEA GO:0009523 photosystem II A photosystem that contains a pheophytin-quinone reaction center with associated accessory pigments and electron carriers. In cyanobacteria and chloroplasts, in the presence of light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone, whereas other photosynthetic bacteria carry out anoxygenic photosynthesis and oxidize other compounds to re-reduce the photoreaction center. IEA Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. IEA GO:0016168 chlorophyll binding GSVIVG01006662001 27320064 27321660 GO:0018298 protein-chromophore linkage The covalent or noncovalent linking of a chromophore to a protein. IEA GO:0009535 chloroplast thylakoid membrane The pigmented membrane of a chloroplast thylakoid. An example of this component is found in Arabidopsis thaliana. IEA Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. IEA GO:0016168 chlorophyll binding GSVIVG01006662001 27320064 27321660 GO:0018298 protein-chromophore linkage The covalent or noncovalent linking of a chromophore to a protein. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. IEA GO:0016168 chlorophyll binding GSVIVG01006662001 27320064 27321660 GO:0018298 protein-chromophore linkage The covalent or noncovalent linking of a chromophore to a protein. IEA GO:0009579 thylakoid A membranous cellular structure that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the plasma membrane. In eukaryotes they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation. IEA Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. IEA GO:0016168 chlorophyll binding GSVIVG01006662001 27320064 27321660 GO:0018298 protein-chromophore linkage The covalent or noncovalent linking of a chromophore to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. IEA GO:0016168 chlorophyll binding GSVIVG01006662001 27320064 27321660 GO:0018298 protein-chromophore linkage The covalent or noncovalent linking of a chromophore to a protein. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. IEA GO:0016168 chlorophyll binding GSVIVG01006662001 27320064 27321660 GO:0018298 protein-chromophore linkage The covalent or noncovalent linking of a chromophore to a protein. IEA GO:0030076 light-harvesting complex A protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center. IEA Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. IEA GO:0016168 chlorophyll binding GSVIVG01006662001 27320064 27321660 GO:0019684 photosynthesis, light reaction The light reactions of photosynthesis, which take place in photosystems II and I. Light energy is harvested and used to power the transfer of electrons among a series of electron donors and acceptors. The final electron acceptor is NADP+, which is reduced to NADPH. NADPH generated from light reactions is used in sugar synthesis in dark reactions. Light reactions also generate a proton motive force across the thylakoid membrane, and the proton gradient is used to synthesize ATP. There are two chemical reactions involved in the light reactions: water oxidation in photosystem II, and NADP reduction in photosystem I. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. IEA GO:0016168 chlorophyll binding GSVIVG01006662001 27320064 27321660 GO:0019684 photosynthesis, light reaction The light reactions of photosynthesis, which take place in photosystems II and I. Light energy is harvested and used to power the transfer of electrons among a series of electron donors and acceptors. The final electron acceptor is NADP+, which is reduced to NADPH. NADPH generated from light reactions is used in sugar synthesis in dark reactions. Light reactions also generate a proton motive force across the thylakoid membrane, and the proton gradient is used to synthesize ATP. There are two chemical reactions involved in the light reactions: water oxidation in photosystem II, and NADP reduction in photosystem I. IEA GO:0009521 photosystem A complex located in a photosynthetic membrane that consists of a photoreaction center associated with accessory pigments and electron carriers. Examples of this component are found in Arabidopsis thaliana and in photosynthetic bacterial and archaeal species. IEA Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. IEA GO:0016168 chlorophyll binding GSVIVG01006662001 27320064 27321660 GO:0019684 photosynthesis, light reaction The light reactions of photosynthesis, which take place in photosystems II and I. Light energy is harvested and used to power the transfer of electrons among a series of electron donors and acceptors. The final electron acceptor is NADP+, which is reduced to NADPH. NADPH generated from light reactions is used in sugar synthesis in dark reactions. Light reactions also generate a proton motive force across the thylakoid membrane, and the proton gradient is used to synthesize ATP. There are two chemical reactions involved in the light reactions: water oxidation in photosystem II, and NADP reduction in photosystem I. IEA GO:0009523 photosystem II A photosystem that contains a pheophytin-quinone reaction center with associated accessory pigments and electron carriers. In cyanobacteria and chloroplasts, in the presence of light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone, whereas other photosynthetic bacteria carry out anoxygenic photosynthesis and oxidize other compounds to re-reduce the photoreaction center. IEA Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. IEA GO:0016168 chlorophyll binding GSVIVG01006662001 27320064 27321660 GO:0019684 photosynthesis, light reaction The light reactions of photosynthesis, which take place in photosystems II and I. Light energy is harvested and used to power the transfer of electrons among a series of electron donors and acceptors. The final electron acceptor is NADP+, which is reduced to NADPH. NADPH generated from light reactions is used in sugar synthesis in dark reactions. Light reactions also generate a proton motive force across the thylakoid membrane, and the proton gradient is used to synthesize ATP. There are two chemical reactions involved in the light reactions: water oxidation in photosystem II, and NADP reduction in photosystem I. IEA GO:0009535 chloroplast thylakoid membrane The pigmented membrane of a chloroplast thylakoid. An example of this component is found in Arabidopsis thaliana. IEA Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. IEA GO:0016168 chlorophyll binding GSVIVG01006662001 27320064 27321660 GO:0019684 photosynthesis, light reaction The light reactions of photosynthesis, which take place in photosystems II and I. Light energy is harvested and used to power the transfer of electrons among a series of electron donors and acceptors. The final electron acceptor is NADP+, which is reduced to NADPH. NADPH generated from light reactions is used in sugar synthesis in dark reactions. Light reactions also generate a proton motive force across the thylakoid membrane, and the proton gradient is used to synthesize ATP. There are two chemical reactions involved in the light reactions: water oxidation in photosystem II, and NADP reduction in photosystem I. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. IEA GO:0016168 chlorophyll binding GSVIVG01006662001 27320064 27321660 GO:0019684 photosynthesis, light reaction The light reactions of photosynthesis, which take place in photosystems II and I. Light energy is harvested and used to power the transfer of electrons among a series of electron donors and acceptors. The final electron acceptor is NADP+, which is reduced to NADPH. NADPH generated from light reactions is used in sugar synthesis in dark reactions. Light reactions also generate a proton motive force across the thylakoid membrane, and the proton gradient is used to synthesize ATP. There are two chemical reactions involved in the light reactions: water oxidation in photosystem II, and NADP reduction in photosystem I. IEA GO:0009579 thylakoid A membranous cellular structure that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the plasma membrane. In eukaryotes they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation. IEA Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. IEA GO:0016168 chlorophyll binding GSVIVG01006662001 27320064 27321660 GO:0019684 photosynthesis, light reaction The light reactions of photosynthesis, which take place in photosystems II and I. Light energy is harvested and used to power the transfer of electrons among a series of electron donors and acceptors. The final electron acceptor is NADP+, which is reduced to NADPH. NADPH generated from light reactions is used in sugar synthesis in dark reactions. Light reactions also generate a proton motive force across the thylakoid membrane, and the proton gradient is used to synthesize ATP. There are two chemical reactions involved in the light reactions: water oxidation in photosystem II, and NADP reduction in photosystem I. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. IEA GO:0016168 chlorophyll binding GSVIVG01006662001 27320064 27321660 GO:0019684 photosynthesis, light reaction The light reactions of photosynthesis, which take place in photosystems II and I. Light energy is harvested and used to power the transfer of electrons among a series of electron donors and acceptors. The final electron acceptor is NADP+, which is reduced to NADPH. NADPH generated from light reactions is used in sugar synthesis in dark reactions. Light reactions also generate a proton motive force across the thylakoid membrane, and the proton gradient is used to synthesize ATP. There are two chemical reactions involved in the light reactions: water oxidation in photosystem II, and NADP reduction in photosystem I. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. IEA GO:0016168 chlorophyll binding GSVIVG01006662001 27320064 27321660 GO:0019684 photosynthesis, light reaction The light reactions of photosynthesis, which take place in photosystems II and I. Light energy is harvested and used to power the transfer of electrons among a series of electron donors and acceptors. The final electron acceptor is NADP+, which is reduced to NADPH. NADPH generated from light reactions is used in sugar synthesis in dark reactions. Light reactions also generate a proton motive force across the thylakoid membrane, and the proton gradient is used to synthesize ATP. There are two chemical reactions involved in the light reactions: water oxidation in photosystem II, and NADP reduction in photosystem I. IEA GO:0030076 light-harvesting complex A protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center. IEA Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. IEA GO:0016168 chlorophyll binding GSVIVG01006662001 27320064 27321660 GO:0009767 photosynthetic electron transport chain A process, occurring as part of photosynthesis, whereby light provides the energy for a series of electron carriers to operate together to transfer electrons and generate a transmembrane electrochemical gradient. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01006662001 27320064 27321660 GO:0009767 photosynthetic electron transport chain A process, occurring as part of photosynthesis, whereby light provides the energy for a series of electron carriers to operate together to transfer electrons and generate a transmembrane electrochemical gradient. IEA GO:0009521 photosystem A complex located in a photosynthetic membrane that consists of a photoreaction center associated with accessory pigments and electron carriers. Examples of this component are found in Arabidopsis thaliana and in photosynthetic bacterial and archaeal species. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01006662001 27320064 27321660 GO:0009767 photosynthetic electron transport chain A process, occurring as part of photosynthesis, whereby light provides the energy for a series of electron carriers to operate together to transfer electrons and generate a transmembrane electrochemical gradient. IEA GO:0009523 photosystem II A photosystem that contains a pheophytin-quinone reaction center with associated accessory pigments and electron carriers. In cyanobacteria and chloroplasts, in the presence of light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone, whereas other photosynthetic bacteria carry out anoxygenic photosynthesis and oxidize other compounds to re-reduce the photoreaction center. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01006662001 27320064 27321660 GO:0009767 photosynthetic electron transport chain A process, occurring as part of photosynthesis, whereby light provides the energy for a series of electron carriers to operate together to transfer electrons and generate a transmembrane electrochemical gradient. IEA GO:0009535 chloroplast thylakoid membrane The pigmented membrane of a chloroplast thylakoid. An example of this component is found in Arabidopsis thaliana. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01006662001 27320064 27321660 GO:0009767 photosynthetic electron transport chain A process, occurring as part of photosynthesis, whereby light provides the energy for a series of electron carriers to operate together to transfer electrons and generate a transmembrane electrochemical gradient. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01006662001 27320064 27321660 GO:0009767 photosynthetic electron transport chain A process, occurring as part of photosynthesis, whereby light provides the energy for a series of electron carriers to operate together to transfer electrons and generate a transmembrane electrochemical gradient. IEA GO:0009579 thylakoid A membranous cellular structure that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the plasma membrane. In eukaryotes they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01006662001 27320064 27321660 GO:0009767 photosynthetic electron transport chain A process, occurring as part of photosynthesis, whereby light provides the energy for a series of electron carriers to operate together to transfer electrons and generate a transmembrane electrochemical gradient. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01006662001 27320064 27321660 GO:0009767 photosynthetic electron transport chain A process, occurring as part of photosynthesis, whereby light provides the energy for a series of electron carriers to operate together to transfer electrons and generate a transmembrane electrochemical gradient. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01006662001 27320064 27321660 GO:0009767 photosynthetic electron transport chain A process, occurring as part of photosynthesis, whereby light provides the energy for a series of electron carriers to operate together to transfer electrons and generate a transmembrane electrochemical gradient. IEA GO:0030076 light-harvesting complex A protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01006662001 27320064 27321660 GO:0009772 photosynthetic electron transport in photosystem II Electrons move from the primary electron acceptor (Quinone, Q) through a chain of electron transport molecules in the thylakoid membrane until they reach the ultimate electron acceptor of Photosystem II, which is plastocyanin (PC). The electron is then passed to the P700 chlorophyll a molecules of the reaction centre of photosystem I. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01006662001 27320064 27321660 GO:0009772 photosynthetic electron transport in photosystem II Electrons move from the primary electron acceptor (Quinone, Q) through a chain of electron transport molecules in the thylakoid membrane until they reach the ultimate electron acceptor of Photosystem II, which is plastocyanin (PC). The electron is then passed to the P700 chlorophyll a molecules of the reaction centre of photosystem I. IEA GO:0009521 photosystem A complex located in a photosynthetic membrane that consists of a photoreaction center associated with accessory pigments and electron carriers. Examples of this component are found in Arabidopsis thaliana and in photosynthetic bacterial and archaeal species. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01006662001 27320064 27321660 GO:0009772 photosynthetic electron transport in photosystem II Electrons move from the primary electron acceptor (Quinone, Q) through a chain of electron transport molecules in the thylakoid membrane until they reach the ultimate electron acceptor of Photosystem II, which is plastocyanin (PC). The electron is then passed to the P700 chlorophyll a molecules of the reaction centre of photosystem I. IEA GO:0009523 photosystem II A photosystem that contains a pheophytin-quinone reaction center with associated accessory pigments and electron carriers. In cyanobacteria and chloroplasts, in the presence of light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone, whereas other photosynthetic bacteria carry out anoxygenic photosynthesis and oxidize other compounds to re-reduce the photoreaction center. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01006662001 27320064 27321660 GO:0009772 photosynthetic electron transport in photosystem II Electrons move from the primary electron acceptor (Quinone, Q) through a chain of electron transport molecules in the thylakoid membrane until they reach the ultimate electron acceptor of Photosystem II, which is plastocyanin (PC). The electron is then passed to the P700 chlorophyll a molecules of the reaction centre of photosystem I. IEA GO:0009535 chloroplast thylakoid membrane The pigmented membrane of a chloroplast thylakoid. An example of this component is found in Arabidopsis thaliana. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01006662001 27320064 27321660 GO:0009772 photosynthetic electron transport in photosystem II Electrons move from the primary electron acceptor (Quinone, Q) through a chain of electron transport molecules in the thylakoid membrane until they reach the ultimate electron acceptor of Photosystem II, which is plastocyanin (PC). The electron is then passed to the P700 chlorophyll a molecules of the reaction centre of photosystem I. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01006662001 27320064 27321660 GO:0009772 photosynthetic electron transport in photosystem II Electrons move from the primary electron acceptor (Quinone, Q) through a chain of electron transport molecules in the thylakoid membrane until they reach the ultimate electron acceptor of Photosystem II, which is plastocyanin (PC). The electron is then passed to the P700 chlorophyll a molecules of the reaction centre of photosystem I. IEA GO:0009579 thylakoid A membranous cellular structure that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the plasma membrane. In eukaryotes they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01006662001 27320064 27321660 GO:0009772 photosynthetic electron transport in photosystem II Electrons move from the primary electron acceptor (Quinone, Q) through a chain of electron transport molecules in the thylakoid membrane until they reach the ultimate electron acceptor of Photosystem II, which is plastocyanin (PC). The electron is then passed to the P700 chlorophyll a molecules of the reaction centre of photosystem I. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01006662001 27320064 27321660 GO:0009772 photosynthetic electron transport in photosystem II Electrons move from the primary electron acceptor (Quinone, Q) through a chain of electron transport molecules in the thylakoid membrane until they reach the ultimate electron acceptor of Photosystem II, which is plastocyanin (PC). The electron is then passed to the P700 chlorophyll a molecules of the reaction centre of photosystem I. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01006662001 27320064 27321660 GO:0009772 photosynthetic electron transport in photosystem II Electrons move from the primary electron acceptor (Quinone, Q) through a chain of electron transport molecules in the thylakoid membrane until they reach the ultimate electron acceptor of Photosystem II, which is plastocyanin (PC). The electron is then passed to the P700 chlorophyll a molecules of the reaction centre of photosystem I. IEA GO:0030076 light-harvesting complex A protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01006662001 27320064 27321660 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01006662001 27320064 27321660 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009521 photosystem A complex located in a photosynthetic membrane that consists of a photoreaction center associated with accessory pigments and electron carriers. Examples of this component are found in Arabidopsis thaliana and in photosynthetic bacterial and archaeal species. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01006662001 27320064 27321660 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009523 photosystem II A photosystem that contains a pheophytin-quinone reaction center with associated accessory pigments and electron carriers. In cyanobacteria and chloroplasts, in the presence of light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone, whereas other photosynthetic bacteria carry out anoxygenic photosynthesis and oxidize other compounds to re-reduce the photoreaction center. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01006662001 27320064 27321660 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009535 chloroplast thylakoid membrane The pigmented membrane of a chloroplast thylakoid. An example of this component is found in Arabidopsis thaliana. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01006662001 27320064 27321660 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01006662001 27320064 27321660 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009579 thylakoid A membranous cellular structure that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the plasma membrane. In eukaryotes they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01006662001 27320064 27321660 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01006662001 27320064 27321660 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01006662001 27320064 27321660 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0030076 light-harvesting complex A protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01006662001 27320064 27321660 GO:0018298 protein-chromophore linkage The covalent or noncovalent linking of a chromophore to a protein. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01006662001 27320064 27321660 GO:0018298 protein-chromophore linkage The covalent or noncovalent linking of a chromophore to a protein. IEA GO:0009521 photosystem A complex located in a photosynthetic membrane that consists of a photoreaction center associated with accessory pigments and electron carriers. Examples of this component are found in Arabidopsis thaliana and in photosynthetic bacterial and archaeal species. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01006662001 27320064 27321660 GO:0018298 protein-chromophore linkage The covalent or noncovalent linking of a chromophore to a protein. IEA GO:0009523 photosystem II A photosystem that contains a pheophytin-quinone reaction center with associated accessory pigments and electron carriers. In cyanobacteria and chloroplasts, in the presence of light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone, whereas other photosynthetic bacteria carry out anoxygenic photosynthesis and oxidize other compounds to re-reduce the photoreaction center. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01006662001 27320064 27321660 GO:0018298 protein-chromophore linkage The covalent or noncovalent linking of a chromophore to a protein. IEA GO:0009535 chloroplast thylakoid membrane The pigmented membrane of a chloroplast thylakoid. An example of this component is found in Arabidopsis thaliana. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01006662001 27320064 27321660 GO:0018298 protein-chromophore linkage The covalent or noncovalent linking of a chromophore to a protein. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01006662001 27320064 27321660 GO:0018298 protein-chromophore linkage The covalent or noncovalent linking of a chromophore to a protein. IEA GO:0009579 thylakoid A membranous cellular structure that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the plasma membrane. In eukaryotes they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01006662001 27320064 27321660 GO:0018298 protein-chromophore linkage The covalent or noncovalent linking of a chromophore to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01006662001 27320064 27321660 GO:0018298 protein-chromophore linkage The covalent or noncovalent linking of a chromophore to a protein. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01006662001 27320064 27321660 GO:0018298 protein-chromophore linkage The covalent or noncovalent linking of a chromophore to a protein. IEA GO:0030076 light-harvesting complex A protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01006662001 27320064 27321660 GO:0019684 photosynthesis, light reaction The light reactions of photosynthesis, which take place in photosystems II and I. Light energy is harvested and used to power the transfer of electrons among a series of electron donors and acceptors. The final electron acceptor is NADP+, which is reduced to NADPH. NADPH generated from light reactions is used in sugar synthesis in dark reactions. Light reactions also generate a proton motive force across the thylakoid membrane, and the proton gradient is used to synthesize ATP. There are two chemical reactions involved in the light reactions: water oxidation in photosystem II, and NADP reduction in photosystem I. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01006662001 27320064 27321660 GO:0019684 photosynthesis, light reaction The light reactions of photosynthesis, which take place in photosystems II and I. Light energy is harvested and used to power the transfer of electrons among a series of electron donors and acceptors. The final electron acceptor is NADP+, which is reduced to NADPH. NADPH generated from light reactions is used in sugar synthesis in dark reactions. Light reactions also generate a proton motive force across the thylakoid membrane, and the proton gradient is used to synthesize ATP. There are two chemical reactions involved in the light reactions: water oxidation in photosystem II, and NADP reduction in photosystem I. IEA GO:0009521 photosystem A complex located in a photosynthetic membrane that consists of a photoreaction center associated with accessory pigments and electron carriers. Examples of this component are found in Arabidopsis thaliana and in photosynthetic bacterial and archaeal species. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01006662001 27320064 27321660 GO:0019684 photosynthesis, light reaction The light reactions of photosynthesis, which take place in photosystems II and I. Light energy is harvested and used to power the transfer of electrons among a series of electron donors and acceptors. The final electron acceptor is NADP+, which is reduced to NADPH. NADPH generated from light reactions is used in sugar synthesis in dark reactions. Light reactions also generate a proton motive force across the thylakoid membrane, and the proton gradient is used to synthesize ATP. There are two chemical reactions involved in the light reactions: water oxidation in photosystem II, and NADP reduction in photosystem I. IEA GO:0009523 photosystem II A photosystem that contains a pheophytin-quinone reaction center with associated accessory pigments and electron carriers. In cyanobacteria and chloroplasts, in the presence of light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone, whereas other photosynthetic bacteria carry out anoxygenic photosynthesis and oxidize other compounds to re-reduce the photoreaction center. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01006662001 27320064 27321660 GO:0019684 photosynthesis, light reaction The light reactions of photosynthesis, which take place in photosystems II and I. Light energy is harvested and used to power the transfer of electrons among a series of electron donors and acceptors. The final electron acceptor is NADP+, which is reduced to NADPH. NADPH generated from light reactions is used in sugar synthesis in dark reactions. Light reactions also generate a proton motive force across the thylakoid membrane, and the proton gradient is used to synthesize ATP. There are two chemical reactions involved in the light reactions: water oxidation in photosystem II, and NADP reduction in photosystem I. IEA GO:0009535 chloroplast thylakoid membrane The pigmented membrane of a chloroplast thylakoid. An example of this component is found in Arabidopsis thaliana. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01006662001 27320064 27321660 GO:0019684 photosynthesis, light reaction The light reactions of photosynthesis, which take place in photosystems II and I. Light energy is harvested and used to power the transfer of electrons among a series of electron donors and acceptors. The final electron acceptor is NADP+, which is reduced to NADPH. NADPH generated from light reactions is used in sugar synthesis in dark reactions. Light reactions also generate a proton motive force across the thylakoid membrane, and the proton gradient is used to synthesize ATP. There are two chemical reactions involved in the light reactions: water oxidation in photosystem II, and NADP reduction in photosystem I. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01006662001 27320064 27321660 GO:0019684 photosynthesis, light reaction The light reactions of photosynthesis, which take place in photosystems II and I. Light energy is harvested and used to power the transfer of electrons among a series of electron donors and acceptors. The final electron acceptor is NADP+, which is reduced to NADPH. NADPH generated from light reactions is used in sugar synthesis in dark reactions. Light reactions also generate a proton motive force across the thylakoid membrane, and the proton gradient is used to synthesize ATP. There are two chemical reactions involved in the light reactions: water oxidation in photosystem II, and NADP reduction in photosystem I. IEA GO:0009579 thylakoid A membranous cellular structure that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the plasma membrane. In eukaryotes they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01006662001 27320064 27321660 GO:0019684 photosynthesis, light reaction The light reactions of photosynthesis, which take place in photosystems II and I. Light energy is harvested and used to power the transfer of electrons among a series of electron donors and acceptors. The final electron acceptor is NADP+, which is reduced to NADPH. NADPH generated from light reactions is used in sugar synthesis in dark reactions. Light reactions also generate a proton motive force across the thylakoid membrane, and the proton gradient is used to synthesize ATP. There are two chemical reactions involved in the light reactions: water oxidation in photosystem II, and NADP reduction in photosystem I. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01006662001 27320064 27321660 GO:0019684 photosynthesis, light reaction The light reactions of photosynthesis, which take place in photosystems II and I. Light energy is harvested and used to power the transfer of electrons among a series of electron donors and acceptors. The final electron acceptor is NADP+, which is reduced to NADPH. NADPH generated from light reactions is used in sugar synthesis in dark reactions. Light reactions also generate a proton motive force across the thylakoid membrane, and the proton gradient is used to synthesize ATP. There are two chemical reactions involved in the light reactions: water oxidation in photosystem II, and NADP reduction in photosystem I. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01006662001 27320064 27321660 GO:0019684 photosynthesis, light reaction The light reactions of photosynthesis, which take place in photosystems II and I. Light energy is harvested and used to power the transfer of electrons among a series of electron donors and acceptors. The final electron acceptor is NADP+, which is reduced to NADPH. NADPH generated from light reactions is used in sugar synthesis in dark reactions. Light reactions also generate a proton motive force across the thylakoid membrane, and the proton gradient is used to synthesize ATP. There are two chemical reactions involved in the light reactions: water oxidation in photosystem II, and NADP reduction in photosystem I. IEA GO:0030076 light-harvesting complex A protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center. IEA Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis. IEA GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GSVIVG01028018001 3230799 3231377 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GSVIVG01023824001 3186256 3187245 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA GSVIVG01023824001 3186256 3187245 GO:0009415 response to water A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water stimulus. IEA GSVIVG01037612001 6242148 6245586 GSVIVG01002016001 32286982 32291623 GSVIVG01008675001 1129776 1134072 GSVIVG01020162001 9565250 9637417 GSVIVG01007788001 9003953 9006962 GSVIVG01032065001 23092290 23096961 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01032065001 23092290 23096961 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008965001 3906073 3907917 GSVIVG01037424001 13993069 14001971 GSVIVG01027843001 8545812 8546558 GSVIVG01030706001 14124804 14196241 GSVIVG01003959001 14057626 14061753 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01022369001 19154716 19155181 GSVIVG01001114001 22724639 22728768 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01010441001 20625401 20652989 GO:0009311 oligosaccharide metabolic process The chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010441001 20625401 20652989 GO:0009311 oligosaccharide metabolic process The chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. IEA Catalysis of the exohydrolysis of the non-reducing terminal glucose residue in the mannosyl-oligosaccharide Glc(3)Man(9)GlcNAc(2). IEA GO:0004573 mannosyl-oligosaccharide glucosidase activity GSVIVG01013007001 10267239 10267661 GSVIVG01026970001 18936175 18939990 GSVIVG01011573001 6328679 6391646 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01011573001 6328679 6391646 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01031507001 17828336 17828767 GSVIVG01015125001 1214222 1216659 GSVIVG01020280001 21934772 21952939 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01020280001 21934772 21952939 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01020280001 21934772 21952939 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01020280001 21934772 21952939 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01008385001 2596174 2605689 GSVIVG01014382001 3265469 3267267 GSVIVG01023164001 21769638 21770230 GSVIVG01009163001 5657908 5661024 GSVIVG01003169001 6023244 6024532 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036788001 22530547 22543278 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01020060001 10977206 10982423 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01020060001 10977206 10982423 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01018108001 6616102 6623426 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01025936001 27008804 27013993 GSVIVG01015207001 1833849 1837293 GO:0043547 positive regulation of GTPase activity Any process that activates or increases the activity of a GTPase. IEA Increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. IEA GO:0005096 GTPase activator activity GSVIVG01020995001 15690674 15841680 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01020995001 15690674 15841680 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01020995001 15690674 15841680 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01020995001 15690674 15841680 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01035100001 1469777 1472603 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016387001 4306929 4308828 GSVIVG01031958001 5692421 5707098 GSVIVG01026194001 13835741 13836698 GSVIVG01034820001 22076995 22078864 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01034820001 22076995 22078864 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024965001 5631311 5644458 GSVIVG01013271001 5811388 5820436 GSVIVG01024531001 9119724 9133237 GSVIVG01037621001 6299239 6306655 GSVIVG01006693001 27592556 27593716 GSVIVG01003193001 7753037 7761919 GSVIVG01035877001 5155700 5171733 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01007705001 10180666 10185047 GSVIVG01022980001 17324884 17329679 GSVIVG01026963001 18982514 18986976 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01026963001 18982514 18986976 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01009253001 6688299 6690573 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01009253001 6688299 6690573 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01009253001 6688299 6690573 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01009253001 6688299 6690573 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01012233001 342583 373752 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01012233001 342583 373752 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01012233001 342583 373752 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01012233001 342583 373752 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031849001 4870222 4872315 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01030837001 17312349 17313419 GSVIVG01008484001 1475025 1475958 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01009786001 11256600 11261386 GO:0009690 cytokinin metabolic process The chemical reactions and pathways involving cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009786001 11256600 11261386 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009786001 11256600 11261386 GO:0009690 cytokinin metabolic process The chemical reactions and pathways involving cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01009786001 11256600 11261386 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01009786001 11256600 11261386 GO:0009690 cytokinin metabolic process The chemical reactions and pathways involving cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators. IEA Catalysis of the reaction: N6-dimethylallyladenine + acceptor + H2O = adenine + 3-methylbut-2-enal + reduced electron acceptor. IEA GO:0019139 cytokinin dehydrogenase activity GSVIVG01009786001 11256600 11261386 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: N6-dimethylallyladenine + acceptor + H2O = adenine + 3-methylbut-2-enal + reduced electron acceptor. IEA GO:0019139 cytokinin dehydrogenase activity GSVIVG01009786001 11256600 11261386 GO:0009690 cytokinin metabolic process The chemical reactions and pathways involving cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01009786001 11256600 11261386 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01021268001 3220547 3222157 GSVIVG01029443001 22838435 22849196 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029443001 22838435 22849196 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029443001 22838435 22849196 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01029443001 22838435 22849196 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01029443001 22838435 22849196 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01029443001 22838435 22849196 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01036376001 4336041 4344318 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01036376001 4336041 4344318 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01003949001 13968386 13969377 GSVIVG01027052001 18344707 18349246 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0000139 Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus. IEA Catalysis of the transfer of a nucleotide-sugar from one side of the membrane to the other. A nucleotide-sugar is any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. IEA GO:0005338 nucleotide-sugar transmembrane transporter activity GSVIVG01027052001 18344707 18349246 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a nucleotide-sugar from one side of the membrane to the other. A nucleotide-sugar is any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. IEA GO:0005338 nucleotide-sugar transmembrane transporter activity GSVIVG01027052001 18344707 18349246 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a nucleotide-sugar from one side of the membrane to the other. A nucleotide-sugar is any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. IEA GO:0005338 nucleotide-sugar transmembrane transporter activity GSVIVG01027052001 18344707 18349246 GO:0008643 carbohydrate transport The directed movement of carbohydrate into, out of, within or between cells by means of some external agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0000139 Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus. IEA Catalysis of the transfer of a nucleotide-sugar from one side of the membrane to the other. A nucleotide-sugar is any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. IEA GO:0005338 nucleotide-sugar transmembrane transporter activity GSVIVG01027052001 18344707 18349246 GO:0008643 carbohydrate transport The directed movement of carbohydrate into, out of, within or between cells by means of some external agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a nucleotide-sugar from one side of the membrane to the other. A nucleotide-sugar is any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. IEA GO:0005338 nucleotide-sugar transmembrane transporter activity GSVIVG01027052001 18344707 18349246 GO:0008643 carbohydrate transport The directed movement of carbohydrate into, out of, within or between cells by means of some external agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a nucleotide-sugar from one side of the membrane to the other. A nucleotide-sugar is any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. IEA GO:0005338 nucleotide-sugar transmembrane transporter activity GSVIVG01027052001 18344707 18349246 GO:0015780 nucleotide-sugar transport The directed movement of nucleotide-sugars into, out of, within or between cells by means of some external agent such as a transporter or pore. Nucleotide-sugars are any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. IEA GO:0000139 Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus. IEA Catalysis of the transfer of a nucleotide-sugar from one side of the membrane to the other. A nucleotide-sugar is any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. IEA GO:0005338 nucleotide-sugar transmembrane transporter activity GSVIVG01027052001 18344707 18349246 GO:0015780 nucleotide-sugar transport The directed movement of nucleotide-sugars into, out of, within or between cells by means of some external agent such as a transporter or pore. Nucleotide-sugars are any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a nucleotide-sugar from one side of the membrane to the other. A nucleotide-sugar is any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. IEA GO:0005338 nucleotide-sugar transmembrane transporter activity GSVIVG01027052001 18344707 18349246 GO:0015780 nucleotide-sugar transport The directed movement of nucleotide-sugars into, out of, within or between cells by means of some external agent such as a transporter or pore. Nucleotide-sugars are any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a nucleotide-sugar from one side of the membrane to the other. A nucleotide-sugar is any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. IEA GO:0005338 nucleotide-sugar transmembrane transporter activity GSVIVG01027052001 18344707 18349246 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0000139 Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus. IEA Catalysis of the transfer of a nucleotide-sugar from one side of the membrane to the other. A nucleotide-sugar is any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. IEA GO:0005338 nucleotide-sugar transmembrane transporter activity GSVIVG01027052001 18344707 18349246 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a nucleotide-sugar from one side of the membrane to the other. A nucleotide-sugar is any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. IEA GO:0005338 nucleotide-sugar transmembrane transporter activity GSVIVG01027052001 18344707 18349246 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a nucleotide-sugar from one side of the membrane to the other. A nucleotide-sugar is any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. IEA GO:0005338 nucleotide-sugar transmembrane transporter activity GSVIVG01027052001 18344707 18349246 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0000139 Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + H+(out) = sugar(in) + H+(in). IEA GO:0005351 sugar:hydrogen symporter activity GSVIVG01027052001 18344707 18349246 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + H+(out) = sugar(in) + H+(in). IEA GO:0005351 sugar:hydrogen symporter activity GSVIVG01027052001 18344707 18349246 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + H+(out) = sugar(in) + H+(in). IEA GO:0005351 sugar:hydrogen symporter activity GSVIVG01027052001 18344707 18349246 GO:0008643 carbohydrate transport The directed movement of carbohydrate into, out of, within or between cells by means of some external agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0000139 Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + H+(out) = sugar(in) + H+(in). IEA GO:0005351 sugar:hydrogen symporter activity GSVIVG01027052001 18344707 18349246 GO:0008643 carbohydrate transport The directed movement of carbohydrate into, out of, within or between cells by means of some external agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + H+(out) = sugar(in) + H+(in). IEA GO:0005351 sugar:hydrogen symporter activity GSVIVG01027052001 18344707 18349246 GO:0008643 carbohydrate transport The directed movement of carbohydrate into, out of, within or between cells by means of some external agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + H+(out) = sugar(in) + H+(in). IEA GO:0005351 sugar:hydrogen symporter activity GSVIVG01027052001 18344707 18349246 GO:0015780 nucleotide-sugar transport The directed movement of nucleotide-sugars into, out of, within or between cells by means of some external agent such as a transporter or pore. Nucleotide-sugars are any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. IEA GO:0000139 Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + H+(out) = sugar(in) + H+(in). IEA GO:0005351 sugar:hydrogen symporter activity GSVIVG01027052001 18344707 18349246 GO:0015780 nucleotide-sugar transport The directed movement of nucleotide-sugars into, out of, within or between cells by means of some external agent such as a transporter or pore. Nucleotide-sugars are any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + H+(out) = sugar(in) + H+(in). IEA GO:0005351 sugar:hydrogen symporter activity GSVIVG01027052001 18344707 18349246 GO:0015780 nucleotide-sugar transport The directed movement of nucleotide-sugars into, out of, within or between cells by means of some external agent such as a transporter or pore. Nucleotide-sugars are any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + H+(out) = sugar(in) + H+(in). IEA GO:0005351 sugar:hydrogen symporter activity GSVIVG01027052001 18344707 18349246 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0000139 Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + H+(out) = sugar(in) + H+(in). IEA GO:0005351 sugar:hydrogen symporter activity GSVIVG01027052001 18344707 18349246 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + H+(out) = sugar(in) + H+(in). IEA GO:0005351 sugar:hydrogen symporter activity GSVIVG01027052001 18344707 18349246 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + H+(out) = sugar(in) + H+(in). IEA GO:0005351 sugar:hydrogen symporter activity GSVIVG01001445001 21071845 21076965 GSVIVG01010371001 19893130 19896199 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01010371001 19893130 19896199 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010371001 19893130 19896199 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01010371001 19893130 19896199 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate. IEA GO:0019205 nucleobase, nucleoside, nucleotide kinase activity GSVIVG01017049001 3774830 3781251 GO:0007031 peroxisome organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules. IEA GO:0005778 peroxisomal membrane The lipid bilayer surrounding a peroxisome. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017049001 3774830 3781251 GO:0007031 peroxisome organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules. IEA GO:0005778 peroxisomal membrane The lipid bilayer surrounding a peroxisome. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01032111001 22587637 22587964 GSVIVG01006472001 26262813 26266267 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01006472001 26262813 26266267 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01006472001 26262813 26266267 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01006472001 26262813 26266267 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01006472001 26262813 26266267 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017626001 2120928 2125287 GSVIVG01027857001 8695388 8700349 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01019987001 11958854 11975969 GSVIVG01032408001 27076964 27079144 GSVIVG01037877001 6815261 6818599 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01027454001 16617750 16619261 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01027454001 16617750 16619261 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01013909001 6653866 6659465 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01013909001 6653866 6659465 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01013909001 6653866 6659465 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01013909001 6653866 6659465 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038518001 10904730 10904951 GSVIVG01015257001 2154799 2159703 GSVIVG01028724001 19395693 19401729 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid. IEA GO:0008378 galactosyltransferase activity GSVIVG01011773001 4273741 4277143 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01011773001 4273741 4277143 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01020249001 22260502 22262536 GSVIVG01013684001 2590934 2592050 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01021498001 6191374 6191726 GSVIVG01028330001 6219878 6224123 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028330001 6219878 6224123 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028330001 6219878 6224123 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028330001 6219878 6224123 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028330001 6219878 6224123 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028330001 6219878 6224123 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028330001 6219878 6224123 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028330001 6219878 6224123 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028330001 6219878 6224123 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028330001 6219878 6224123 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028330001 6219878 6224123 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028330001 6219878 6224123 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028330001 6219878 6224123 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01028330001 6219878 6224123 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01028330001 6219878 6224123 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01028330001 6219878 6224123 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01028330001 6219878 6224123 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01028330001 6219878 6224123 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01028330001 6219878 6224123 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. IEA GO:0016615 malate dehydrogenase activity GSVIVG01028330001 6219878 6224123 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. IEA GO:0016615 malate dehydrogenase activity GSVIVG01028330001 6219878 6224123 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. IEA GO:0016615 malate dehydrogenase activity GSVIVG01028330001 6219878 6224123 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. IEA GO:0016615 malate dehydrogenase activity GSVIVG01028330001 6219878 6224123 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. IEA GO:0016615 malate dehydrogenase activity GSVIVG01028330001 6219878 6224123 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. IEA GO:0016615 malate dehydrogenase activity GSVIVG01028330001 6219878 6224123 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01028330001 6219878 6224123 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01028330001 6219878 6224123 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01028330001 6219878 6224123 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01028330001 6219878 6224123 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01028330001 6219878 6224123 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01028330001 6219878 6224123 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids. IEA GO:0030060 L-malate dehydrogenase activity GSVIVG01028330001 6219878 6224123 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids. IEA GO:0030060 L-malate dehydrogenase activity GSVIVG01028330001 6219878 6224123 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids. IEA GO:0030060 L-malate dehydrogenase activity GSVIVG01028330001 6219878 6224123 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids. IEA GO:0030060 L-malate dehydrogenase activity GSVIVG01028330001 6219878 6224123 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids. IEA GO:0030060 L-malate dehydrogenase activity GSVIVG01028330001 6219878 6224123 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids. IEA GO:0030060 L-malate dehydrogenase activity GSVIVG01025943001 26908703 26916821 GSVIVG01029637001 20340410 20342364 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01029637001 20340410 20342364 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01029637001 20340410 20342364 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015934 large ribosomal subunit The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01029637001 20340410 20342364 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01029637001 20340410 20342364 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01029637001 20340410 20342364 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015934 large ribosomal subunit The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01016351001 4729670 4736260 GSVIVG01028961001 17044212 17047672 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01018868001 19076791 19078109 GSVIVG01023433001 12098784 12099502 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01023433001 12098784 12099502 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01031987001 23736941 23738759 GSVIVG01000394001 622769 673148 GSVIVG01015171001 1543610 1545830 GO:0006499 N-terminal protein myristoylation The covalent or non-covalent attachment of a myristoyl moiety to the N-terminal amino acid residue of a protein. IEA Catalysis of the reaction: tetradecanoyl-CoA + glycyl-peptide = CoA + N-tetradecanoylglycyl-peptide. IEA GO:0004379 glycylpeptide N-tetradecanoyltransferase activity GSVIVG01020924001 17060021 17088912 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with transfer RNA. IEA GO:0000049 tRNA binding GSVIVG01020924001 17060021 17088912 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with transfer RNA. IEA GO:0000049 tRNA binding GSVIVG01020924001 17060021 17088912 GO:0006431 methionyl-tRNA aminoacylation The process of coupling methionine to methionyl-tRNA, catalyzed by methionyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with transfer RNA. IEA GO:0000049 tRNA binding GSVIVG01020924001 17060021 17088912 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020924001 17060021 17088912 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020924001 17060021 17088912 GO:0006431 methionyl-tRNA aminoacylation The process of coupling methionine to methionyl-tRNA, catalyzed by methionyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020924001 17060021 17088912 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01020924001 17060021 17088912 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01020924001 17060021 17088912 GO:0006431 methionyl-tRNA aminoacylation The process of coupling methionine to methionyl-tRNA, catalyzed by methionyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01020924001 17060021 17088912 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met). IEA GO:0004825 methionine-tRNA ligase activity GSVIVG01020924001 17060021 17088912 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met). IEA GO:0004825 methionine-tRNA ligase activity GSVIVG01020924001 17060021 17088912 GO:0006431 methionyl-tRNA aminoacylation The process of coupling methionine to methionyl-tRNA, catalyzed by methionyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met). IEA GO:0004825 methionine-tRNA ligase activity GSVIVG01020924001 17060021 17088912 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020924001 17060021 17088912 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020924001 17060021 17088912 GO:0006431 methionyl-tRNA aminoacylation The process of coupling methionine to methionyl-tRNA, catalyzed by methionyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028827001 18317818 18324441 GSVIVG01025146001 3984762 3985627 Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01025146001 3984762 3985627 Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01003378001 9573592 9573654 GSVIVG01023903001 2571165 2580535 GSVIVG01000277001 20978835 20984201 GO:0030071 regulation of mitotic metaphase/anaphase transition Any process that modulates the frequency, rate or extent of the onset of anaphase (chromosome movement) in the mitotic cell cycle. IEA GO:0005680 anaphase-promoting complex A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016103001 19001249 19005040 GSVIVG01003641001 11433034 11440626 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003641001 11433034 11440626 GO:0006284 base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032217001 13087451 13105562 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032217001 13087451 13105562 Catalysis of the transfer of a functional group from one position to another within a single molecule. IEA GO:0016866 intramolecular transferase activity GSVIVG01009838001 11710236 11711686 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01009838001 11710236 11711686 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01009838001 11710236 11711686 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01017217001 5541481 5561835 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01017217001 5541481 5561835 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022664001 14308450 14309297 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01034843001 22543843 22544496 GSVIVG01037796001 7866657 7868625 GSVIVG01028043001 3380955 3389790 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: UDP-glucose + D-fructose = UDP + sucrose. IEA GO:0016157 sucrose synthase activity GSVIVG01012499001 41781 42992 GSVIVG01011862001 3485712 3512371 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01032073001 22972611 22978215 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01032073001 22972611 22978215 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01003645001 11615319 11615618 GSVIVG01022182001 17253879 17256929 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01022182001 17253879 17256929 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01032322001 15060015 15064508 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01032322001 15060015 15064508 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01030030001 9001078 9003062 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01014085001 263273 265338 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: bile acid(out) + Na+(out) = bile acid(in) + Na+(in). IEA GO:0008508 bile acid:sodium symporter activity GSVIVG01019554001 1576333 1578897 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01013588001 21215159 21216491 GSVIVG01014591001 5406936 5410337 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01023952001 2213052 2224945 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01003500001 10783712 10786920 GSVIVG01037319001 15819728 15820536 GSVIVG01012235001 334518 337539 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01012235001 334518 337539 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007592001 11538507 11549899 GSVIVG01038686001 21010767 21014022 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01009184001 5855909 5869152 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01017890001 4417474 4420789 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01024293001 607611 610206 GO:0006559 L-phenylalanine catabolic process The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024293001 607611 610206 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024293001 607611 610206 GO:0006559 L-phenylalanine catabolic process The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of ammonia (NH3) to another substance via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. IEA GO:0016211 ammonia ligase activity GSVIVG01024293001 607611 610206 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of ammonia (NH3) to another substance via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. IEA GO:0016211 ammonia ligase activity GSVIVG01024293001 607611 610206 GO:0006559 L-phenylalanine catabolic process The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate. IEA GO:0016841 ammonia-lyase activity GSVIVG01024293001 607611 610206 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate. IEA GO:0016841 ammonia-lyase activity GSVIVG01033490001 20285553 20294526 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01033490001 20285553 20294526 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01033490001 20285553 20294526 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01033490001 20285553 20294526 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033490001 20285553 20294526 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033490001 20285553 20294526 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01008338001 3130839 3135923 GSVIVG01024104001 1025537 1040108 GSVIVG01024751001 7234106 7235008 Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01037900001 6521843 6537917 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012225001 433721 439652 GSVIVG01018617001 12176866 12181868 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018617001 12176866 12181868 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01031525001 17621769 17636601 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01031525001 17621769 17636601 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01013390001 764518 766414 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025858001 11119758 11124665 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor. IEA GO:0004368 glycerol-3-phosphate dehydrogenase activity GSVIVG01025858001 11119758 11124665 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor. IEA GO:0004368 glycerol-3-phosphate dehydrogenase activity GSVIVG01025858001 11119758 11124665 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025858001 11119758 11124665 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01017178001 5037569 5040878 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01017178001 5037569 5040878 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01003916001 13555572 13561387 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01003916001 13555572 13561387 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01003916001 13555572 13561387 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01000620001 13983530 13983968 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01000620001 13983530 13983968 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01036713001 23447078 23447990 GSVIVG01035910001 5682268 5696450 GSVIVG01026614001 21012616 21016482 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01038404001 11826647 11828812 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01038404001 11826647 11828812 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01038404001 11826647 11828812 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038404001 11826647 11828812 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022710001 15383670 15384908 GSVIVG01031748001 4027214 4030627 GSVIVG01038331001 13113098 13120193 GSVIVG01016918001 2559182 2565635 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01016918001 2559182 2565635 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016918001 2559182 2565635 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01004847001 9409 12893 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01010270001 18645674 18653975 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01010270001 18645674 18653975 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01010270001 18645674 18653975 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01010270001 18645674 18653975 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01021049001 14610220 14614850 Interacting selectively and non-covalently with selenium (Se). IEA GO:0008430 selenium binding GSVIVG01000836001 2737508 2739405 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01000836001 2737508 2739405 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034755001 9032832 9035020 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01034755001 9032832 9035020 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01034755001 9032832 9035020 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01034755001 9032832 9035020 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027006001 18614312 18617280 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01027006001 18614312 18617280 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01025916001 27268865 27284577 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01025916001 27268865 27284577 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01007041001 29841479 29841749 GSVIVG01017507001 9605317 9606596 GSVIVG01018280001 12061756 12101151 GSVIVG01022128001 16796032 16803981 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01022128001 16796032 16803981 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01022128001 16796032 16803981 GO:0009688 abscisic acid biosynthetic process The chemical reactions and pathways resulting in the formation of abscisic acid, 5-(1-hydroxy-2,6,6,trimethyl-4-oxocyclohex-2-en-1-y1)-3-methylpenta-2,4-dienoic acid. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01022128001 16796032 16803981 GO:0009688 abscisic acid biosynthetic process The chemical reactions and pathways resulting in the formation of abscisic acid, 5-(1-hydroxy-2,6,6,trimethyl-4-oxocyclohex-2-en-1-y1)-3-methylpenta-2,4-dienoic acid. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01022128001 16796032 16803981 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01022128001 16796032 16803981 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01022128001 16796032 16803981 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of the reactions: zeaxanthin + NAD(P)H + H+ + O2 = antheraxanthin + NAD(P)+ + H2O and antheraxanthin + NAD(P)H + H+ + O2 = violaxanthin + NAD(P)+ + H2O. IEA GO:0009540 zeaxanthin epoxidase activity GSVIVG01022128001 16796032 16803981 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reactions: zeaxanthin + NAD(P)H + H+ + O2 = antheraxanthin + NAD(P)+ + H2O and antheraxanthin + NAD(P)H + H+ + O2 = violaxanthin + NAD(P)+ + H2O. IEA GO:0009540 zeaxanthin epoxidase activity GSVIVG01022128001 16796032 16803981 GO:0009688 abscisic acid biosynthetic process The chemical reactions and pathways resulting in the formation of abscisic acid, 5-(1-hydroxy-2,6,6,trimethyl-4-oxocyclohex-2-en-1-y1)-3-methylpenta-2,4-dienoic acid. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of the reactions: zeaxanthin + NAD(P)H + H+ + O2 = antheraxanthin + NAD(P)+ + H2O and antheraxanthin + NAD(P)H + H+ + O2 = violaxanthin + NAD(P)+ + H2O. IEA GO:0009540 zeaxanthin epoxidase activity GSVIVG01022128001 16796032 16803981 GO:0009688 abscisic acid biosynthetic process The chemical reactions and pathways resulting in the formation of abscisic acid, 5-(1-hydroxy-2,6,6,trimethyl-4-oxocyclohex-2-en-1-y1)-3-methylpenta-2,4-dienoic acid. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reactions: zeaxanthin + NAD(P)H + H+ + O2 = antheraxanthin + NAD(P)+ + H2O and antheraxanthin + NAD(P)H + H+ + O2 = violaxanthin + NAD(P)+ + H2O. IEA GO:0009540 zeaxanthin epoxidase activity GSVIVG01022128001 16796032 16803981 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of the reactions: zeaxanthin + NAD(P)H + H+ + O2 = antheraxanthin + NAD(P)+ + H2O and antheraxanthin + NAD(P)H + H+ + O2 = violaxanthin + NAD(P)+ + H2O. IEA GO:0009540 zeaxanthin epoxidase activity GSVIVG01022128001 16796032 16803981 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reactions: zeaxanthin + NAD(P)H + H+ + O2 = antheraxanthin + NAD(P)+ + H2O and antheraxanthin + NAD(P)H + H+ + O2 = violaxanthin + NAD(P)+ + H2O. IEA GO:0009540 zeaxanthin epoxidase activity GSVIVG01022128001 16796032 16803981 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022128001 16796032 16803981 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022128001 16796032 16803981 GO:0009688 abscisic acid biosynthetic process The chemical reactions and pathways resulting in the formation of abscisic acid, 5-(1-hydroxy-2,6,6,trimethyl-4-oxocyclohex-2-en-1-y1)-3-methylpenta-2,4-dienoic acid. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022128001 16796032 16803981 GO:0009688 abscisic acid biosynthetic process The chemical reactions and pathways resulting in the formation of abscisic acid, 5-(1-hydroxy-2,6,6,trimethyl-4-oxocyclohex-2-en-1-y1)-3-methylpenta-2,4-dienoic acid. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022128001 16796032 16803981 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022128001 16796032 16803981 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01035467001 1483002 1484002 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01005756001 21857883 21865769 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01017209001 5440861 5443991 GSVIVG01011597001 6107794 6110562 Catalysis of the removal of a phosphate group from phosphorylated myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol. IEA GO:0004437 inositol or phosphatidylinositol phosphatase activity GSVIVG01024412001 2214321 2217689 GSVIVG01022480001 3553935 3577026 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion. IEA GO:0005484 SNAP receptor activity GSVIVG01022480001 3553935 3577026 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion. IEA GO:0005484 SNAP receptor activity GSVIVG01022480001 3553935 3577026 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01022480001 3553935 3577026 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01007673001 10607116 10607889 GSVIVG01021302001 3713473 3713571 GSVIVG01019637001 2123935 2128496 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GSVIVG01025587001 13841068 13860354 GSVIVG01026408001 15730840 15732344 GSVIVG01012871001 6387806 6395130 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01019927001 4509449 4511161 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01022186001 17268969 17274776 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01018728001 20357829 20371146 GSVIVG01021729001 10190935 10196288 GSVIVG01009898001 12230581 12231893 GSVIVG01014876001 11043268 11044130 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014876001 11043268 11044130 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029317001 16944908 16945654 GSVIVG01023875001 2811714 2814381 GSVIVG01011232001 9892027 9893933 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01013577001 21119196 21124358 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01013479001 4258 27771 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01013479001 4258 27771 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01013479001 4258 27771 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01013479001 4258 27771 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01013479001 4258 27771 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01013479001 4258 27771 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01013479001 4258 27771 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01013479001 4258 27771 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025003001 5358706 5365099 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025003001 5358706 5365099 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025003001 5358706 5365099 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025003001 5358706 5365099 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025003001 5358706 5365099 GO:0045226 extracellular polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025003001 5358706 5365099 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025003001 5358706 5365099 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025003001 5358706 5365099 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025003001 5358706 5365099 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025003001 5358706 5365099 GO:0045226 extracellular polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025003001 5358706 5365099 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + NADPH + H+. IEA GO:0008831 dTDP-4-dehydrorhamnose reductase activity GSVIVG01025003001 5358706 5365099 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + NADPH + H+. IEA GO:0008831 dTDP-4-dehydrorhamnose reductase activity GSVIVG01025003001 5358706 5365099 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + NADPH + H+. IEA GO:0008831 dTDP-4-dehydrorhamnose reductase activity GSVIVG01025003001 5358706 5365099 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + NADPH + H+. IEA GO:0008831 dTDP-4-dehydrorhamnose reductase activity GSVIVG01025003001 5358706 5365099 GO:0045226 extracellular polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. IEA Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + NADPH + H+. IEA GO:0008831 dTDP-4-dehydrorhamnose reductase activity GSVIVG01025003001 5358706 5365099 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. IEA GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GSVIVG01025003001 5358706 5365099 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. IEA GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GSVIVG01025003001 5358706 5365099 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. IEA GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GSVIVG01025003001 5358706 5365099 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. IEA GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GSVIVG01025003001 5358706 5365099 GO:0045226 extracellular polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. IEA Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. IEA GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GSVIVG01025003001 5358706 5365099 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01025003001 5358706 5365099 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01025003001 5358706 5365099 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01025003001 5358706 5365099 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01025003001 5358706 5365099 GO:0045226 extracellular polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01012218001 482030 495575 GSVIVG01037808001 7704338 7705956 GSVIVG01006043001 23438483 23448770 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01004941001 21705192 21716307 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: ATP + L-aspartate = ADP + 4-phospho-L-aspartate. IEA GO:0004072 aspartate kinase activity GSVIVG01004941001 21705192 21716307 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the reaction: ATP + L-aspartate = ADP + 4-phospho-L-aspartate. IEA GO:0004072 aspartate kinase activity GSVIVG01004941001 21705192 21716307 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. IEA GO:0016597 amino acid binding GSVIVG01004941001 21705192 21716307 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. IEA GO:0016597 amino acid binding GSVIVG01035664001 3118486 3139639 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01033194001 9399944 9400803 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01033194001 9399944 9400803 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01028163001 4325736 4326393 GSVIVG01027167001 17291335 17292656 GSVIVG01024672001 7898080 7902492 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024672001 7898080 7902492 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024672001 7898080 7902492 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024672001 7898080 7902492 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024672001 7898080 7902492 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024672001 7898080 7902492 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024672001 7898080 7902492 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024672001 7898080 7902492 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024672001 7898080 7902492 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024672001 7898080 7902492 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01024672001 7898080 7902492 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01024672001 7898080 7902492 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01034365001 17388710 17389412 GSVIVG01030968001 19996334 19997360 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with manganese (Mn) ions. IEA GO:0030145 manganese ion binding GSVIVG01030968001 19996334 19997360 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Functions in the storage of nutritious substrates. IEA GO:0045735 nutrient reservoir activity GSVIVG01030968001 19996334 19997360 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01029026001 10902340 10909796 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029026001 10902340 10909796 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01026976001 18891903 18892654 GO:0009269 response to desiccation A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a desiccation stimulus, extreme dryness resulting from the prolonged deprivation of water. IEA GSVIVG01020968001 16222930 16228234 GSVIVG01031857001 4943035 4950015 GO:0005992 trehalose biosynthetic process The chemical reactions and pathways resulting in the formation of trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024593001 8582160 8583020 GSVIVG01001182001 1035911 1039856 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0005839 proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. IEA GO:0004175 endopeptidase activity GSVIVG01001182001 1035911 1039856 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0005839 proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. IEA Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. IEA GO:0004298 threonine-type endopeptidase activity GSVIVG01008973001 3963411 3965374 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012139001 1107410 1111568 GSVIVG01008749001 1691068 1697042 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01008749001 1691068 1697042 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01008749001 1691068 1697042 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01008749001 1691068 1697042 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01008749001 1691068 1697042 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01008749001 1691068 1697042 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01008749001 1691068 1697042 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Catalysis of the reaction: 4 ATP + 2 phosphorylase b = 4 ADP + phosphorylase a. IEA GO:0004689 phosphorylase kinase activity GSVIVG01008749001 1691068 1697042 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Catalysis of the reaction: 4 ATP + 2 phosphorylase b = 4 ADP + phosphorylase a. IEA GO:0004689 phosphorylase kinase activity GSVIVG01008749001 1691068 1697042 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01008749001 1691068 1697042 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01008749001 1691068 1697042 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01008749001 1691068 1697042 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01008749001 1691068 1697042 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01008749001 1691068 1697042 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01008749001 1691068 1697042 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. IEA GO:0005516 calmodulin binding GSVIVG01008749001 1691068 1697042 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. IEA GO:0005516 calmodulin binding GSVIVG01008749001 1691068 1697042 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008749001 1691068 1697042 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019166001 15766799 15766894 GSVIVG01034188001 14560586 14563925 GO:0001522 pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01034188001 14560586 14563925 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01034188001 14560586 14563925 GO:0009451 RNA modification The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01034188001 14560586 14563925 GO:0001522 pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs. IEA Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. IEA GO:0009982 pseudouridine synthase activity GSVIVG01034188001 14560586 14563925 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. IEA GO:0009982 pseudouridine synthase activity GSVIVG01034188001 14560586 14563925 GO:0009451 RNA modification The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. IEA Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. IEA GO:0009982 pseudouridine synthase activity GSVIVG01007903001 7725751 7727693 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01033875001 17083102 17094082 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01000560001 7071571 7079766 GSVIVG01034659001 12951743 12957126 GSVIVG01008144001 5396606 5397916 Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate. IEA GO:0008146 sulfotransferase activity GSVIVG01031353001 122622 125099 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01031353001 122622 125099 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01031353001 122622 125099 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01031353001 122622 125099 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01031353001 122622 125099 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031353001 122622 125099 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026975001 18895933 18896484 GO:0009269 response to desiccation A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a desiccation stimulus, extreme dryness resulting from the prolonged deprivation of water. IEA GSVIVG01016318001 5153151 5166524 Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01016318001 5153151 5166524 Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01025036001 5092816 5097801 GSVIVG01022675001 14558290 14566882 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022675001 14558290 14566882 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028307001 5943985 5945312 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01027686001 14297501 14300135 GSVIVG01038549001 21954571 21960272 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01016095001 18883843 18888663 GSVIVG01017512001 9747693 9749444 GSVIVG01027389001 15407169 15408812 GSVIVG01022959001 17560241 17561192 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01019712001 2637037 2644475 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019712001 2637037 2644475 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019712001 2637037 2644475 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019712001 2637037 2644475 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019712001 2637037 2644475 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01019712001 2637037 2644475 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01019712001 2637037 2644475 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01019712001 2637037 2644475 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01034268001 13760556 13784958 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018553001 13472093 13475070 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01018553001 13472093 13475070 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01018553001 13472093 13475070 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015935 small ribosomal subunit The smaller of the two subunits of a ribosome. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01018553001 13472093 13475070 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01018553001 13472093 13475070 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01018553001 13472093 13475070 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015935 small ribosomal subunit The smaller of the two subunits of a ribosome. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01035685001 3333418 3333701 GSVIVG01000967001 22328030 22331014 GSVIVG01014259001 2074707 2079553 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01014259001 2074707 2079553 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01014259001 2074707 2079553 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01014259001 2074707 2079553 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01014259001 2074707 2079553 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01014259001 2074707 2079553 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01014259001 2074707 2079553 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01014259001 2074707 2079553 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01035389001 941254 945402 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01011073001 1805847 1813018 GO:0006414 translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01011073001 1805847 1813018 GO:0006414 translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Functions in chain elongation during polypeptide synthesis at the ribosome. IEA GO:0003746 translation elongation factor activity GSVIVG01011073001 1805847 1813018 GO:0006414 translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01011073001 1805847 1813018 GO:0006414 translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01012196001 628682 633595 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01012196001 628682 633595 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01029167001 18980840 18982644 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01033880001 17050520 17062140 Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GSVIVG01016368001 4412409 4418158 GSVIVG01019829001 3716500 3720934 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01019829001 3716500 3720934 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01020290001 21839338 21841479 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020290001 21839338 21841479 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020290001 21839338 21841479 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020290001 21839338 21841479 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024703001 7615484 7620474 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of potassium ions (K+) from one side of a membrane to the other. IEA GO:0015079 potassium ion transmembrane transporter activity GSVIVG01019529001 1370272 1378550 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. IEA GO:0004969 histamine receptor activity GSVIVG01019529001 1370272 1378550 GO:0051205 protein insertion into membrane The process by which a protein is incorporated into a biological membrane. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. IEA GO:0004969 histamine receptor activity GSVIVG01020840001 1207508 1232321 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01020840001 1207508 1232321 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01010149001 16384423 16391085 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01010149001 16384423 16391085 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01010149001 16384423 16391085 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010149001 16384423 16391085 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017793001 3518865 3526139 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017793001 3518865 3526139 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01036803001 22340452 22349741 GSVIVG01018550001 13505182 13505349 GSVIVG01030383001 5120074 5121792 GSVIVG01010960001 2626616 2632200 GSVIVG01038635001 21301557 21303346 GSVIVG01006080001 41191455 41193999 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01006080001 41191455 41193999 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01019798001 3408484 3412272 GSVIVG01001771001 2992099 2993513 GSVIVG01014199001 1394614 1399067 GSVIVG01034746001 8876000 8895143 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01034746001 8876000 8895143 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034746001 8876000 8895143 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01034746001 8876000 8895143 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01017909001 4549693 4553760 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017909001 4549693 4553760 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01022566001 5156853 5163974 GSVIVG01025110001 4346954 4348962 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025110001 4346954 4348962 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025110001 4346954 4348962 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01025110001 4346954 4348962 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01000743001 323141 324150 GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA GSVIVG01000743001 323141 324150 GO:0009523 photosystem II A photosystem that contains a pheophytin-quinone reaction center with associated accessory pigments and electron carriers. In cyanobacteria and chloroplasts, in the presence of light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone, whereas other photosynthetic bacteria carry out anoxygenic photosynthesis and oxidize other compounds to re-reduce the photoreaction center. IEA GSVIVG01023802001 3383813 3388437 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01030905001 18806399 18817306 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01031480001 18099731 18108530 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + Na+(out) = amino acid(in) + Na+(in). IEA GO:0005283 sodium:amino acid symporter activity GSVIVG01025156001 3902421 3913394 GSVIVG01020762001 2282320 2292432 GSVIVG01023776001 10944879 10946544 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023776001 10944879 10946544 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01000325001 11392767 11402213 GSVIVG01036405001 4693690 4695556 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01036405001 4693690 4695556 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01036405001 4693690 4695556 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01036405001 4693690 4695556 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01036405001 4693690 4695556 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01036405001 4693690 4695556 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01036405001 4693690 4695556 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01036405001 4693690 4695556 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01036405001 4693690 4695556 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036405001 4693690 4695556 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036405001 4693690 4695556 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036405001 4693690 4695556 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036405001 4693690 4695556 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01036405001 4693690 4695556 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01036405001 4693690 4695556 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01036405001 4693690 4695556 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01034063001 15457244 15471385 Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. IEA GO:0005089 Rho guanyl-nucleotide exchange factor activity GSVIVG01019725001 2766798 2767868 GSVIVG01020178001 9381743 9382568 GSVIVG01010056001 13920144 13948282 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01010056001 13920144 13948282 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01010056001 13920144 13948282 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01010056001 13920144 13948282 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032593001 28650741 28662629 GSVIVG01004746001 15834979 15836811 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01004746001 15834979 15836811 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01004746001 15834979 15836811 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01004746001 15834979 15836811 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01004746001 15834979 15836811 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01004746001 15834979 15836811 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01004746001 15834979 15836811 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01004746001 15834979 15836811 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01032412001 27122268 27132579 GO:0008283 cell proliferation The multiplication or reproduction of cells, resulting in the expansion of a cell population. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA GSVIVG01032412001 27122268 27132579 GO:0008283 cell proliferation The multiplication or reproduction of cells, resulting in the expansion of a cell population. IEA GO:0005730 nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. IEA GSVIVG01036317001 3748985 3751400 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01036317001 3748985 3751400 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01019494001 1094699 1097114 GSVIVG01028212001 4662306 4665218 GSVIVG01015385001 3182279 3187055 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01015385001 3182279 3187055 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015385001 3182279 3187055 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01035842001 4797333 4800203 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01035842001 4797333 4800203 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01035842001 4797333 4800203 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01035842001 4797333 4800203 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035842001 4797333 4800203 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003862001 12990213 12992754 GO:0006544 glycine metabolic process The chemical reactions and pathways involving glycine, aminoethanoic acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003862001 12990213 12992754 GO:0006563 L-serine metabolic process The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003862001 12990213 12992754 GO:0006544 glycine metabolic process The chemical reactions and pathways involving glycine, aminoethanoic acid. IEA Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine. IEA GO:0004372 glycine hydroxymethyltransferase activity GSVIVG01003862001 12990213 12992754 GO:0006563 L-serine metabolic process The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. IEA Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine. IEA GO:0004372 glycine hydroxymethyltransferase activity GSVIVG01003862001 12990213 12992754 GO:0006544 glycine metabolic process The chemical reactions and pathways involving glycine, aminoethanoic acid. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01003862001 12990213 12992754 GO:0006563 L-serine metabolic process The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01015176001 1583535 1589900 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01015176001 1583535 1589900 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01015176001 1583535 1589900 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01015176001 1583535 1589900 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01015176001 1583535 1589900 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033510001 20172216 20175669 GSVIVG01019980001 12043065 12043439 GSVIVG01024453001 2750340 2766738 GSVIVG01030249001 9897783 9903825 GSVIVG01036687001 23845782 23846168 GSVIVG01019553001 1570283 1576084 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01038478001 10125780 10126001 GSVIVG01008077001 6012605 6021669 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01008077001 6012605 6021669 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01008077001 6012605 6021669 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01008077001 6012605 6021669 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01008077001 6012605 6021669 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035083001 1354934 1357002 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion. IEA GO:0004806 triglyceride lipase activity GSVIVG01027562001 15567783 15569113 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01027562001 15567783 15569113 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA A ligand-dependent receptor found in the nucleus of the cell. IEA GO:0004879 ligand-dependent nuclear receptor activity GSVIVG01027562001 15567783 15569113 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01027562001 15567783 15569113 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01001451001 21120946 21122468 GSVIVG01018186001 13435712 13452407 GO:0006414 translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01018186001 13435712 13452407 GO:0006414 translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Functions in chain elongation during polypeptide synthesis at the ribosome. IEA GO:0003746 translation elongation factor activity GSVIVG01018186001 13435712 13452407 GO:0006414 translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01018186001 13435712 13452407 GO:0006414 translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01017367001 7425779 7426273 GSVIVG01027861001 8732862 8736105 GSVIVG01019875001 4131461 4138394 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019875001 4131461 4138394 GO:0008299 isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019875001 4131461 4138394 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA. IEA GO:0004421 hydroxymethylglutaryl-CoA synthase activity GSVIVG01019875001 4131461 4138394 GO:0008299 isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. IEA Catalysis of the reaction: acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA. IEA GO:0004421 hydroxymethylglutaryl-CoA synthase activity GSVIVG01019582001 1733795 1737112 GSVIVG01030714001 14444245 14448249 GSVIVG01000935001 22044691 22044819 GSVIVG01018698001 10997864 10998220 GSVIVG01023864001 2903441 2909631 GO:0008643 carbohydrate transport The directed movement of carbohydrate into, out of, within or between cells by means of some external agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0000139 Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus. IEA Catalysis of the transfer of a nucleotide-sugar from one side of the membrane to the other. A nucleotide-sugar is any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. IEA GO:0005338 nucleotide-sugar transmembrane transporter activity GSVIVG01023864001 2903441 2909631 GO:0008643 carbohydrate transport The directed movement of carbohydrate into, out of, within or between cells by means of some external agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a nucleotide-sugar from one side of the membrane to the other. A nucleotide-sugar is any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. IEA GO:0005338 nucleotide-sugar transmembrane transporter activity GSVIVG01023864001 2903441 2909631 GO:0015780 nucleotide-sugar transport The directed movement of nucleotide-sugars into, out of, within or between cells by means of some external agent such as a transporter or pore. Nucleotide-sugars are any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. IEA GO:0000139 Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus. IEA Catalysis of the transfer of a nucleotide-sugar from one side of the membrane to the other. A nucleotide-sugar is any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. IEA GO:0005338 nucleotide-sugar transmembrane transporter activity GSVIVG01023864001 2903441 2909631 GO:0015780 nucleotide-sugar transport The directed movement of nucleotide-sugars into, out of, within or between cells by means of some external agent such as a transporter or pore. Nucleotide-sugars are any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a nucleotide-sugar from one side of the membrane to the other. A nucleotide-sugar is any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. IEA GO:0005338 nucleotide-sugar transmembrane transporter activity GSVIVG01023864001 2903441 2909631 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0000139 Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus. IEA Catalysis of the transfer of a nucleotide-sugar from one side of the membrane to the other. A nucleotide-sugar is any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. IEA GO:0005338 nucleotide-sugar transmembrane transporter activity GSVIVG01023864001 2903441 2909631 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a nucleotide-sugar from one side of the membrane to the other. A nucleotide-sugar is any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. IEA GO:0005338 nucleotide-sugar transmembrane transporter activity GSVIVG01023864001 2903441 2909631 GO:0008643 carbohydrate transport The directed movement of carbohydrate into, out of, within or between cells by means of some external agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0000139 Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + H+(out) = sugar(in) + H+(in). IEA GO:0005351 sugar:hydrogen symporter activity GSVIVG01023864001 2903441 2909631 GO:0008643 carbohydrate transport The directed movement of carbohydrate into, out of, within or between cells by means of some external agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + H+(out) = sugar(in) + H+(in). IEA GO:0005351 sugar:hydrogen symporter activity GSVIVG01023864001 2903441 2909631 GO:0015780 nucleotide-sugar transport The directed movement of nucleotide-sugars into, out of, within or between cells by means of some external agent such as a transporter or pore. Nucleotide-sugars are any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. IEA GO:0000139 Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + H+(out) = sugar(in) + H+(in). IEA GO:0005351 sugar:hydrogen symporter activity GSVIVG01023864001 2903441 2909631 GO:0015780 nucleotide-sugar transport The directed movement of nucleotide-sugars into, out of, within or between cells by means of some external agent such as a transporter or pore. Nucleotide-sugars are any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + H+(out) = sugar(in) + H+(in). IEA GO:0005351 sugar:hydrogen symporter activity GSVIVG01023864001 2903441 2909631 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0000139 Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + H+(out) = sugar(in) + H+(in). IEA GO:0005351 sugar:hydrogen symporter activity GSVIVG01023864001 2903441 2909631 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + H+(out) = sugar(in) + H+(in). IEA GO:0005351 sugar:hydrogen symporter activity GSVIVG01018072001 6217429 6221815 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01007553001 12212622 12215044 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01007553001 12212622 12215044 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01015413001 3394759 3399173 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01015413001 3394759 3399173 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01015413001 3394759 3399173 GO:0008272 sulfate transport The directed movement of sulfate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01015413001 3394759 3399173 GO:0008272 sulfate transport The directed movement of sulfate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01015413001 3394759 3399173 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01015413001 3394759 3399173 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01015413001 3394759 3399173 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01015413001 3394759 3399173 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01015413001 3394759 3399173 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01015413001 3394759 3399173 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01015413001 3394759 3399173 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01015413001 3394759 3399173 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01015413001 3394759 3399173 GO:0008272 sulfate transport The directed movement of sulfate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01015413001 3394759 3399173 GO:0008272 sulfate transport The directed movement of sulfate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01015413001 3394759 3399173 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01015413001 3394759 3399173 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01015413001 3394759 3399173 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01015413001 3394759 3399173 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01015413001 3394759 3399173 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01015413001 3394759 3399173 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01015413001 3394759 3399173 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01015413001 3394759 3399173 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01015413001 3394759 3399173 GO:0008272 sulfate transport The directed movement of sulfate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01015413001 3394759 3399173 GO:0008272 sulfate transport The directed movement of sulfate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01015413001 3394759 3399173 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01015413001 3394759 3399173 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01015413001 3394759 3399173 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01015413001 3394759 3399173 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01015413001 3394759 3399173 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01015413001 3394759 3399173 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01018216001 13143262 13153230 GO:0005643 nuclear pore Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined. IEA The action of a molecule that contributes to the structural integrity of the nuclear pore complex. IEA GO:0017056 structural constituent of nuclear pore GSVIVG01022280001 18143009 18152081 GSVIVG01014475001 4271944 4272189 GSVIVG01020169001 9477543 9478317 GSVIVG01033497001 20242313 20243150 GSVIVG01035867001 5048917 5059782 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GSVIVG01022606001 5882896 5886842 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01022606001 5882896 5886842 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01022606001 5882896 5886842 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01022606001 5882896 5886842 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01022606001 5882896 5886842 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01022606001 5882896 5886842 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01022606001 5882896 5886842 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020057001 10991459 11002007 GSVIVG01016688001 376382 377940 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of a lipid or phospholipid. IEA GO:0016298 lipase activity GSVIVG01016688001 376382 377940 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01006408001 25688083 25690247 Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01026739001 5906661 5907095 GSVIVG01020632001 3645654 3647304 Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. IEA GO:0008171 O-methyltransferase activity GSVIVG01024264001 357486 360969 GSVIVG01006231001 23801969 23804537 GSVIVG01019796001 3382880 3384672 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01019796001 3382880 3384672 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01019796001 3382880 3384672 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01019796001 3382880 3384672 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013462001 249338 255983 GSVIVG01017794001 3528167 3536780 GSVIVG01025702001 12834504 12843024 GSVIVG01022922001 18015768 18018294 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01022922001 18015768 18018294 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01022922001 18015768 18018294 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022922001 18015768 18018294 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022922001 18015768 18018294 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01022922001 18015768 18018294 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01022922001 18015768 18018294 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01022922001 18015768 18018294 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01000904001 21761404 21762187 GSVIVG01035355001 710289 715166 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01035355001 710289 715166 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. IEA GO:0008137 NADH dehydrogenase (ubiquinone) activity GSVIVG01035355001 710289 715166 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01035355001 710289 715166 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016651 oxidoreductase activity, acting on NADH or NADPH GSVIVG01035355001 710289 715166 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01035355001 710289 715166 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds. IEA GO:0048038 quinone binding GSVIVG01035355001 710289 715166 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01035355001 710289 715166 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051539 4 iron, 4 sulfur cluster binding GSVIVG01004822001 5436281 5437031 GSVIVG01011546001 12528921 12532950 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011546001 12528921 12532950 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01011679001 5283992 5288251 GSVIVG01018382001 10010002 10022494 GO:0009116 nucleoside metabolic process The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine). IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01018382001 10010002 10022494 GO:0009156 ribonucleoside monophosphate biosynthetic process The chemical reactions and pathways resulting in the formation of a ribonucleoside monophosphate, a glycosamine consisting of a base linked to a ribose sugar esterified with phosphate on its glycose moiety. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01018382001 10010002 10022494 GO:0009165 nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates). IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01018382001 10010002 10022494 GO:0044249 cellular biosynthetic process The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01018382001 10010002 10022494 GO:0009116 nucleoside metabolic process The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine). IEA Catalysis of the reaction: ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate. IEA GO:0004749 ribose phosphate diphosphokinase activity GSVIVG01018382001 10010002 10022494 GO:0009156 ribonucleoside monophosphate biosynthetic process The chemical reactions and pathways resulting in the formation of a ribonucleoside monophosphate, a glycosamine consisting of a base linked to a ribose sugar esterified with phosphate on its glycose moiety. IEA Catalysis of the reaction: ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate. IEA GO:0004749 ribose phosphate diphosphokinase activity GSVIVG01018382001 10010002 10022494 GO:0009165 nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates). IEA Catalysis of the reaction: ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate. IEA GO:0004749 ribose phosphate diphosphokinase activity GSVIVG01018382001 10010002 10022494 GO:0044249 cellular biosynthetic process The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. IEA Catalysis of the reaction: ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate. IEA GO:0004749 ribose phosphate diphosphokinase activity GSVIVG01034563001 19427037 19431008 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01034563001 19427037 19431008 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01024769001 7113631 7114670 GSVIVG01031536001 17387661 17394952 GSVIVG01017323001 6719400 6722605 GSVIVG01021994001 4584375 4585118 GSVIVG01010189001 17019947 17056744 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01009986001 13112575 13112793 GSVIVG01004915001 4766576 4768165 GSVIVG01036993001 9150089 9150574 GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA GSVIVG01018145001 13939742 13946793 GSVIVG01031113001 2057510 2058550 GSVIVG01036669001 20037047 20038529 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024844001 6501665 6503989 GSVIVG01016204001 6627347 6639044 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GSVIVG01010686001 11766439 11766693 GSVIVG01000173001 15855261 15859539 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01003852001 12860984 12880192 GO:0006544 glycine metabolic process The chemical reactions and pathways involving glycine, aminoethanoic acid. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003852001 12860984 12880192 GO:0006563 L-serine metabolic process The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003852001 12860984 12880192 GO:0006544 glycine metabolic process The chemical reactions and pathways involving glycine, aminoethanoic acid. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine. IEA GO:0004372 glycine hydroxymethyltransferase activity GSVIVG01003852001 12860984 12880192 GO:0006563 L-serine metabolic process The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine. IEA GO:0004372 glycine hydroxymethyltransferase activity GSVIVG01003852001 12860984 12880192 GO:0006544 glycine metabolic process The chemical reactions and pathways involving glycine, aminoethanoic acid. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01003852001 12860984 12880192 GO:0006563 L-serine metabolic process The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01009708001 10663450 10663542 GSVIVG01001820001 26079381 26091241 GO:0000228 nuclear chromosome A chromosome found in the nucleus of a eukaryotic cell. IEA GSVIVG01003983001 26474481 26476807 GSVIVG01027682001 14350696 14353989 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01007944001 7307383 7310961 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01007944001 7307383 7310961 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01007944001 7307383 7310961 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01007944001 7307383 7310961 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01007944001 7307383 7310961 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036302001 3564037 3564877 GSVIVG01034710001 8150739 8202754 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01034710001 8150739 8202754 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01034710001 8150739 8202754 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01034710001 8150739 8202754 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032447001 27507728 27510391 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01032447001 27507728 27510391 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01032447001 27507728 27510391 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01032447001 27507728 27510391 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01032447001 27507728 27510391 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01032447001 27507728 27510391 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01002712001 35957880 35963974 GSVIVG01008407001 2379238 2381736 GSVIVG01008482001 1497931 1501792 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01008482001 1497931 1501792 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01008482001 1497931 1501792 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01030833001 17263917 17267133 GSVIVG01011040001 2052641 2055335 GSVIVG01002790001 36426855 36428037 GO:0006413 translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. IEA Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. IEA GO:0003743 translation initiation factor activity GSVIVG01009528001 9077712 9084453 GSVIVG01025069001 4796857 4798635 GSVIVG01002902001 37128016 37130745 GSVIVG01009559001 9408600 9419486 GO:0033014 tetrapyrrole biosynthetic process The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. IEA Catalysis of the reaction: hydroxymethylbilane = uroporphyrinogen-III + H2O. IEA GO:0004852 uroporphyrinogen-III synthase activity GSVIVG01028294001 5837981 5838834 GSVIVG01001353001 23878994 23882869 GSVIVG01004971001 17192179 17194178 GO:0042773 ATP synthesis coupled electron transport The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP. IEA Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. IEA GO:0008137 NADH dehydrogenase (ubiquinone) activity GSVIVG01004971001 17192179 17194178 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. IEA GO:0008137 NADH dehydrogenase (ubiquinone) activity GSVIVG01031801001 4477403 4479789 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01031801001 4477403 4479789 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01031801001 4477403 4479789 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01031801001 4477403 4479789 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01029410001 16741315 16749308 Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01013329001 12153120 12175274 GO:0007205 activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway The initiation of the activity of the inactive enzyme protein kinase C as the result of a series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol 3-phosphate. IEA GO:0004143 diacylglycerol kinase activity GSVIVG01023226001 20939461 20942142 GSVIVG01038792001 1015667 1048056 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025896001 27407573 27411680 GSVIVG01033413001 20888585 20892129 GO:0006801 superoxide metabolic process The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01033413001 20888585 20892129 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01007866001 8187656 8195243 GSVIVG01029821001 3278 4778 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01029821001 3278 4778 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01029821001 3278 4778 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01029821001 3278 4778 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01029821001 3278 4778 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029821001 3278 4778 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007719001 9941524 9942662 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01007719001 9941524 9942662 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds. IEA GO:0015035 protein disulfide oxidoreductase activity GSVIVG01024528001 9149450 9150922 GSVIVG01035487001 1697445 1702417 GO:0007166 cell surface receptor linked signaling pathway Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01035487001 1697445 1702417 GO:0007166 cell surface receptor linked signaling pathway Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01035487001 1697445 1702417 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01035487001 1697445 1702417 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01035487001 1697445 1702417 GO:0007166 cell surface receptor linked signaling pathway Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01035487001 1697445 1702417 GO:0007166 cell surface receptor linked signaling pathway Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01035487001 1697445 1702417 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01035487001 1697445 1702417 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01035487001 1697445 1702417 GO:0007166 cell surface receptor linked signaling pathway Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate). IEA GO:0030552 cAMP binding GSVIVG01035487001 1697445 1702417 GO:0007166 cell surface receptor linked signaling pathway Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate). IEA GO:0030552 cAMP binding GSVIVG01035487001 1697445 1702417 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate). IEA GO:0030552 cAMP binding GSVIVG01035487001 1697445 1702417 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate). IEA GO:0030552 cAMP binding GSVIVG01034280001 14029233 14037913 GO:0009089 lysine biosynthetic process via diaminopimelate The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01034280001 14029233 14037913 GO:0009089 lysine biosynthetic process via diaminopimelate The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate. IEA Catalysis of the reaction: meso-2,6-diaminoheptanedioate = L-lysine + CO2. IEA GO:0008836 diaminopimelate decarboxylase activity GSVIVG01027976001 2921714 2926772 GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01027976001 2921714 2926772 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01027138001 17515331 17515982 GSVIVG01024320001 836173 849589 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01024320001 836173 849589 GO:0006419 alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01024320001 836173 849589 GO:0043039 tRNA aminoacylation The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01024320001 836173 849589 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01024320001 836173 849589 GO:0006419 alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01024320001 836173 849589 GO:0043039 tRNA aminoacylation The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01024320001 836173 849589 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala). IEA GO:0004813 alanine-tRNA ligase activity GSVIVG01024320001 836173 849589 GO:0006419 alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala). IEA GO:0004813 alanine-tRNA ligase activity GSVIVG01024320001 836173 849589 GO:0043039 tRNA aminoacylation The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala). IEA GO:0004813 alanine-tRNA ligase activity GSVIVG01024320001 836173 849589 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024320001 836173 849589 GO:0006419 alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024320001 836173 849589 GO:0043039 tRNA aminoacylation The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024320001 836173 849589 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances via a carbon-oxygen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate, to form aminoacyl-tRNA or a related compound. IEA GO:0016876 ligase activity, forming aminoacyl-tRNA and related compounds GSVIVG01024320001 836173 849589 GO:0006419 alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances via a carbon-oxygen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate, to form aminoacyl-tRNA or a related compound. IEA GO:0016876 ligase activity, forming aminoacyl-tRNA and related compounds GSVIVG01024320001 836173 849589 GO:0043039 tRNA aminoacylation The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances via a carbon-oxygen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate, to form aminoacyl-tRNA or a related compound. IEA GO:0016876 ligase activity, forming aminoacyl-tRNA and related compounds GSVIVG01035134001 1748259 1750088 GSVIVG01001375001 24087613 24091305 GSVIVG01019704001 2577443 2580032 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01028753001 19171528 19172421 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028753001 19171528 19172421 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01016458001 3701110 3709563 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01016458001 3701110 3709563 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01016458001 3701110 3709563 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01016458001 3701110 3709563 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01016458001 3701110 3709563 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01016458001 3701110 3709563 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01016458001 3701110 3709563 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01016458001 3701110 3709563 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01016458001 3701110 3709563 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01016458001 3701110 3709563 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01016458001 3701110 3709563 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01016458001 3701110 3709563 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01027156001 17375822 17379543 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01027156001 17375822 17379543 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01027156001 17375822 17379543 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01027156001 17375822 17379543 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01006992001 29637705 29643312 GSVIVG01018025001 5569273 5571487 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01001156001 1190489 1221867 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. IEA GO:0008080 N-acetyltransferase activity GSVIVG01009497001 8866981 8871345 GSVIVG01017620001 2067904 2068838 GSVIVG01025449001 760071 764273 GSVIVG01005552001 40626916 40628172 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01005552001 40626916 40628172 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01005552001 40626916 40628172 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01029304001 17233107 17237329 GO:0019538 protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01003843001 20612272 20621048 GSVIVG01004673001 39539993 39541913 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01004673001 39539993 39541913 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01004673001 39539993 39541913 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01004673001 39539993 39541913 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01004673001 39539993 39541913 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035920001 5852144 5852980 GSVIVG01017435001 8472956 8477925 GSVIVG01004817001 140847 150797 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01004817001 140847 150797 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01004817001 140847 150797 Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01004817001 140847 150797 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01003974001 26417448 26420108 GO:0043461 proton-transporting ATP synthase complex assembly The aggregation, arrangement and bonding together of a proton-transporting ATP synthase (also known as F-type ATPase), a two-sector ATPase found in the inner membrane of mitochondria and chloroplasts, and in bacterial plasma membranes. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01034357001 17560093 17576724 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01006508001 42528458 42530464 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01006508001 42528458 42530464 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01006508001 42528458 42530464 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01006508001 42528458 42530464 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01005132001 18464580 18469118 GO:0009306 protein secretion The controlled release of proteins from a cell or group of cells. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01005132001 18464580 18469118 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01022604001 5855478 5859158 GSVIVG01018528001 13779137 13785485 GSVIVG01001368001 24048949 24053351 GSVIVG01019639001 2133566 2137775 GSVIVG01025717001 12688180 12693642 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025717001 12688180 12693642 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025717001 12688180 12693642 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01025717001 12688180 12693642 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01025717001 12688180 12693642 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA A sigma factor is the promoter specificity subunit of eubacterial-type multisubunit RNA polymerases, those whose core subunit composition is often described as alpha(2)-beta-beta-prime. (This type of multisubunit RNA polymerase complex is known to be found in eubacteria and plant plastids). Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, this binds specifically to promoter sequences, with the sigma factor making sequence specific contacts with the promoter elements. The sigma subunit is released from the elongating form of the polymerase and is thus free to act catalytically for multiple RNA polymerase core enzymes. IEA GO:0016987 sigma factor activity GSVIVG01025717001 12688180 12693642 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA A sigma factor is the promoter specificity subunit of eubacterial-type multisubunit RNA polymerases, those whose core subunit composition is often described as alpha(2)-beta-beta-prime. (This type of multisubunit RNA polymerase complex is known to be found in eubacteria and plant plastids). Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, this binds specifically to promoter sequences, with the sigma factor making sequence specific contacts with the promoter elements. The sigma subunit is released from the elongating form of the polymerase and is thus free to act catalytically for multiple RNA polymerase core enzymes. IEA GO:0016987 sigma factor activity GSVIVG01033164001 8773510 8788445 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01033164001 8773510 8788445 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01033164001 8773510 8788445 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01033164001 8773510 8788445 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01033164001 8773510 8788445 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01033164001 8773510 8788445 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01033164001 8773510 8788445 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01033164001 8773510 8788445 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01033164001 8773510 8788445 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01033164001 8773510 8788445 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01033164001 8773510 8788445 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01033164001 8773510 8788445 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01033164001 8773510 8788445 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01033164001 8773510 8788445 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01033164001 8773510 8788445 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01033164001 8773510 8788445 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01033164001 8773510 8788445 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01033164001 8773510 8788445 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01033164001 8773510 8788445 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01033164001 8773510 8788445 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01033164001 8773510 8788445 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033164001 8773510 8788445 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033164001 8773510 8788445 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033164001 8773510 8788445 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033164001 8773510 8788445 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033164001 8773510 8788445 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01033164001 8773510 8788445 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01033164001 8773510 8788445 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01033164001 8773510 8788445 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01033164001 8773510 8788445 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01017492001 9402590 9410239 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01017492001 9402590 9410239 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01008929001 3491630 3505392 GO:0006464 protein modification process The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008929001 3491630 3505392 GO:0006464 protein modification process The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). IEA Catalysis of the reaction: ATP + biotin + apo-(acetyl-CoA:carbon-dioxide ligase (ADP forming)) = AMP + diphosphate + (acetyl-CoA:carbon-dioxide ligase (ADP forming)). IEA GO:0004077 biotin-[acetyl-CoA-carboxylase] ligase activity GSVIVG01011920001 3008001 3011436 GSVIVG01014624001 5799685 5805676 GSVIVG01015301001 2492484 2493296 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015301001 2492484 2493296 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015301001 2492484 2493296 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01015301001 2492484 2493296 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01015301001 2492484 2493296 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01015301001 2492484 2493296 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01024863001 6383254 6387541 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01024936001 5904833 5911379 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01001701001 12256604 12295018 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01001701001 12256604 12295018 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01025484001 399160 413510 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029599001 20914531 20915764 GSVIVG01034011001 15906526 15920190 GSVIVG01006120001 41806927 41807333 GSVIVG01037549001 11608995 11630915 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01037549001 11608995 11630915 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01037549001 11608995 11630915 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01037549001 11608995 11630915 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01037549001 11608995 11630915 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01037549001 11608995 11630915 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01037549001 11608995 11630915 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01009654001 10227177 10230335 GO:0008299 isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. IEA GSVIVG01011357001 28927148 28934113 Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01011357001 28927148 28934113 Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01021815001 7030945 7031107 GSVIVG01002278001 33933888 33943300 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01002278001 33933888 33943300 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01002278001 33933888 33943300 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01002278001 33933888 33943300 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01002278001 33933888 33943300 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01002278001 33933888 33943300 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01002278001 33933888 33943300 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01002278001 33933888 33943300 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01028747001 19205045 19206556 GSVIVG01006062001 40954779 40957490 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. IEA GO:0004175 endopeptidase activity GSVIVG01006062001 40954779 40957490 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01006062001 40954779 40957490 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01021185001 2369365 2374461 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021185001 2369365 2374461 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021185001 2369365 2374461 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021185001 2369365 2374461 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021185001 2369365 2374461 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021185001 2369365 2374461 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021185001 2369365 2374461 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01021185001 2369365 2374461 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01021185001 2369365 2374461 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01021185001 2369365 2374461 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01021185001 2369365 2374461 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01021185001 2369365 2374461 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01021185001 2369365 2374461 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021185001 2369365 2374461 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021185001 2369365 2374461 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021185001 2369365 2374461 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021185001 2369365 2374461 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021185001 2369365 2374461 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021185001 2369365 2374461 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. IEA GO:0016615 malate dehydrogenase activity GSVIVG01021185001 2369365 2374461 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. IEA GO:0016615 malate dehydrogenase activity GSVIVG01021185001 2369365 2374461 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. IEA GO:0016615 malate dehydrogenase activity GSVIVG01021185001 2369365 2374461 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. IEA GO:0016615 malate dehydrogenase activity GSVIVG01021185001 2369365 2374461 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. IEA GO:0016615 malate dehydrogenase activity GSVIVG01021185001 2369365 2374461 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. IEA GO:0016615 malate dehydrogenase activity GSVIVG01021185001 2369365 2374461 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01021185001 2369365 2374461 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01021185001 2369365 2374461 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01021185001 2369365 2374461 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01021185001 2369365 2374461 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01021185001 2369365 2374461 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01021185001 2369365 2374461 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids. IEA GO:0030060 L-malate dehydrogenase activity GSVIVG01021185001 2369365 2374461 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids. IEA GO:0030060 L-malate dehydrogenase activity GSVIVG01021185001 2369365 2374461 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids. IEA GO:0030060 L-malate dehydrogenase activity GSVIVG01021185001 2369365 2374461 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids. IEA GO:0030060 L-malate dehydrogenase activity GSVIVG01021185001 2369365 2374461 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids. IEA GO:0030060 L-malate dehydrogenase activity GSVIVG01021185001 2369365 2374461 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids. IEA GO:0030060 L-malate dehydrogenase activity GSVIVG01028049001 3438989 3440381 GSVIVG01016084001 18621684 18627731 GSVIVG01019078001 16985685 16993625 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028617001 10811636 10813039 GO:0009405 pathogenesis The set of specific processes that generate the ability of an organism to cause disease in another. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA GSVIVG01006220001 23744477 23745358 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016651 oxidoreductase activity, acting on NADH or NADPH GSVIVG01006220001 23744477 23745358 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds. IEA GO:0048038 quinone binding GSVIVG01006220001 23744477 23745358 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01029148001 19145520 19180435 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01029148001 19145520 19180435 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01029148001 19145520 19180435 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01029148001 19145520 19180435 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029148001 19145520 19180435 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008654001 74094 79126 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01008654001 74094 79126 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01008654001 74094 79126 GO:0006426 glycyl-tRNA aminoacylation The process of coupling glycine to glycyl-tRNA, catalyzed by glycyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01008654001 74094 79126 GO:0006433 prolyl-tRNA aminoacylation The process of coupling proline to prolyl-tRNA, catalyzed by prolyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01008654001 74094 79126 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01008654001 74094 79126 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01008654001 74094 79126 GO:0006426 glycyl-tRNA aminoacylation The process of coupling glycine to glycyl-tRNA, catalyzed by glycyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01008654001 74094 79126 GO:0006433 prolyl-tRNA aminoacylation The process of coupling proline to prolyl-tRNA, catalyzed by prolyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01008654001 74094 79126 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly). IEA GO:0004820 glycine-tRNA ligase activity GSVIVG01008654001 74094 79126 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly). IEA GO:0004820 glycine-tRNA ligase activity GSVIVG01008654001 74094 79126 GO:0006426 glycyl-tRNA aminoacylation The process of coupling glycine to glycyl-tRNA, catalyzed by glycyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly). IEA GO:0004820 glycine-tRNA ligase activity GSVIVG01008654001 74094 79126 GO:0006433 prolyl-tRNA aminoacylation The process of coupling proline to prolyl-tRNA, catalyzed by prolyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly). IEA GO:0004820 glycine-tRNA ligase activity GSVIVG01008654001 74094 79126 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro). IEA GO:0004827 proline-tRNA ligase activity GSVIVG01008654001 74094 79126 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro). IEA GO:0004827 proline-tRNA ligase activity GSVIVG01008654001 74094 79126 GO:0006426 glycyl-tRNA aminoacylation The process of coupling glycine to glycyl-tRNA, catalyzed by glycyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro). IEA GO:0004827 proline-tRNA ligase activity GSVIVG01008654001 74094 79126 GO:0006433 prolyl-tRNA aminoacylation The process of coupling proline to prolyl-tRNA, catalyzed by prolyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro). IEA GO:0004827 proline-tRNA ligase activity GSVIVG01008654001 74094 79126 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008654001 74094 79126 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008654001 74094 79126 GO:0006426 glycyl-tRNA aminoacylation The process of coupling glycine to glycyl-tRNA, catalyzed by glycyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008654001 74094 79126 GO:0006433 prolyl-tRNA aminoacylation The process of coupling proline to prolyl-tRNA, catalyzed by prolyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019527001 1349772 1359322 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015250001 2105030 2118781 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015250001 2105030 2118781 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01015250001 2105030 2118781 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01015250001 2105030 2118781 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01016337001 4830849 4835628 GSVIVG01022266001 18015097 18015438 GSVIVG01007527001 12706475 12706819 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01007527001 12706475 12706819 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01015811001 17740389 17741429 GSVIVG01009251001 6652256 6660443 GO:0006397 mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01009251001 6652256 6660443 GO:0006397 mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01015226001 1960915 1966799 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01015226001 1960915 1966799 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01015226001 1960915 1966799 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01015226001 1960915 1966799 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035435001 1246997 1249312 GSVIVG01026562001 21801184 21807342 GSVIVG01002284001 34024729 34033103 GSVIVG01033503001 20203291 20204233 GO:0009790 embryo development The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant. IEA GSVIVG01005246001 19815713 19816678 GSVIVG01030476001 5990357 5993590 GSVIVG01010860001 16762386 16772741 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01010860001 16762386 16772741 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01010860001 16762386 16772741 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01010860001 16762386 16772741 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01010860001 16762386 16772741 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01010860001 16762386 16772741 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01010860001 16762386 16772741 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01010860001 16762386 16772741 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01010860001 16762386 16772741 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01010860001 16762386 16772741 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01007966001 7096186 7098427 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01007966001 7096186 7098427 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01014328001 2699751 2702129 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014328001 2699751 2702129 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014328001 2699751 2702129 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014328001 2699751 2702129 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014328001 2699751 2702129 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014328001 2699751 2702129 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014328001 2699751 2702129 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014328001 2699751 2702129 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014328001 2699751 2702129 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01014328001 2699751 2702129 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01036465001 22377584 22390052 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01036465001 22377584 22390052 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01036465001 22377584 22390052 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01036465001 22377584 22390052 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033305001 21658540 21665616 GSVIVG01033081001 25593503 25595677 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01033081001 25593503 25595677 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01033081001 25593503 25595677 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01033081001 25593503 25595677 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01014735001 9072485 9077519 GO:0000398 nuclear mRNA splicing, via spliceosome The joining together of exons from one or more primary transcripts of nuclear messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. IEA GO:0005681 spliceosomal complex Any of a series of ribonucleoprotein complexes that contain RNA and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the splicing of a messenger RNA primary transcript to excise an intron. IEA GSVIVG01017247001 5882989 5883913 GSVIVG01029439001 22888656 22889142 GSVIVG01038504001 10585210 10585332 GSVIVG01001911001 7136361 7137189 GSVIVG01023624001 8156476 8157879 GO:0006566 threonine metabolic process The chemical reactions and pathways involving threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins. IEA Catalysis of the reaction: ATP + L-homoserine = ADP + O-phospho-L-homoserine. IEA GO:0004413 homoserine kinase activity GSVIVG01023624001 8156476 8157879 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA Catalysis of the reaction: ATP + L-homoserine = ADP + O-phospho-L-homoserine. IEA GO:0004413 homoserine kinase activity GSVIVG01023624001 8156476 8157879 GO:0006566 threonine metabolic process The chemical reactions and pathways involving threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023624001 8156476 8157879 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023624001 8156476 8157879 GO:0006566 threonine metabolic process The chemical reactions and pathways involving threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01023624001 8156476 8157879 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01034093001 15193127 15196432 GSVIVG01033599001 19416562 19430211 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01033599001 19416562 19430211 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033599001 19416562 19430211 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the reaction: ATP + pyruvate = ADP + phosphoenolpyruvate. IEA GO:0004743 pyruvate kinase activity GSVIVG01033599001 19416562 19430211 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Interacting selectively and non-covalently with potassium (K+) ions. IEA GO:0030955 potassium ion binding GSVIVG01017800001 3570833 3573423 GSVIVG01020427001 19592331 19597027 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01020427001 19592331 19597027 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020682001 3130501 3132071 GSVIVG01022005001 4394262 4395066 GSVIVG01015064001 802881 802997 GSVIVG01018065001 6056509 6156452 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018065001 6056509 6156452 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018065001 6056509 6156452 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018065001 6056509 6156452 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018065001 6056509 6156452 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01018065001 6056509 6156452 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01018065001 6056509 6156452 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01018065001 6056509 6156452 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01018065001 6056509 6156452 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018065001 6056509 6156452 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018065001 6056509 6156452 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018065001 6056509 6156452 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018065001 6056509 6156452 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of calcium (Ca) ions from one side of a membrane to the other. IEA GO:0015085 calcium ion transmembrane transporter activity GSVIVG01018065001 6056509 6156452 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of calcium (Ca) ions from one side of a membrane to the other. IEA GO:0015085 calcium ion transmembrane transporter activity GSVIVG01018065001 6056509 6156452 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of calcium (Ca) ions from one side of a membrane to the other. IEA GO:0015085 calcium ion transmembrane transporter activity GSVIVG01018065001 6056509 6156452 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of calcium (Ca) ions from one side of a membrane to the other. IEA GO:0015085 calcium ion transmembrane transporter activity GSVIVG01018065001 6056509 6156452 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01018065001 6056509 6156452 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01018065001 6056509 6156452 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01018065001 6056509 6156452 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01018065001 6056509 6156452 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01018065001 6056509 6156452 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01018065001 6056509 6156452 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01018065001 6056509 6156452 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01002050001 32467921 32468366 GSVIVG01011872001 3375071 3376413 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035290001 81666 94722 GSVIVG01007915001 7601652 7602915 GSVIVG01018988001 18045319 18047078 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01018988001 18045319 18047078 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01018988001 18045319 18047078 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01018988001 18045319 18047078 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01038330001 13079192 13080608 Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01030647001 7461781 7463233 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01030647001 7461781 7463233 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01004270001 37875573 37880860 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01010785001 22562078 22564255 GSVIVG01036155001 20010457 20010648 GSVIVG01015360001 2976639 2980025 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01015360001 2976639 2980025 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01015360001 2976639 2980025 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022529001 4413432 4413827 GSVIVG01026824001 20165400 20179331 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026824001 20165400 20179331 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026824001 20165400 20179331 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026824001 20165400 20179331 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate. IEA GO:0004470 malic enzyme activity GSVIVG01026824001 20165400 20179331 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate. IEA GO:0004470 malic enzyme activity GSVIVG01026824001 20165400 20179331 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate. IEA GO:0004470 malic enzyme activity GSVIVG01026824001 20165400 20179331 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01026824001 20165400 20179331 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01026824001 20165400 20179331 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01026824001 20165400 20179331 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026824001 20165400 20179331 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026824001 20165400 20179331 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026824001 20165400 20179331 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01026824001 20165400 20179331 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01026824001 20165400 20179331 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01026824001 20165400 20179331 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01026824001 20165400 20179331 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01026824001 20165400 20179331 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01026824001 20165400 20179331 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01026824001 20165400 20179331 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01026824001 20165400 20179331 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01026824001 20165400 20179331 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01026824001 20165400 20179331 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01026824001 20165400 20179331 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01026824001 20165400 20179331 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01026824001 20165400 20179331 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01026824001 20165400 20179331 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01026824001 20165400 20179331 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01026824001 20165400 20179331 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01026824001 20165400 20179331 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01035396001 991579 994919 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01035396001 991579 994919 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01035396001 991579 994919 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01035396001 991579 994919 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01035396001 991579 994919 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01035396001 991579 994919 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01035396001 991579 994919 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water. IEA GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water GSVIVG01035396001 991579 994919 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water. IEA GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water GSVIVG01035396001 991579 994919 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water. IEA GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water GSVIVG01035396001 991579 994919 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01035396001 991579 994919 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01035396001 991579 994919 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01023925001 2454189 2455085 GSVIVG01010267001 18621157 18622440 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01010267001 18621157 18622440 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01010267001 18621157 18622440 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01010267001 18621157 18622440 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01023319001 19771095 19771506 GSVIVG01016720001 621138 627644 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016720001 621138 627644 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01018761001 20116692 20121210 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018761001 20116692 20121210 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01006467001 26211204 26221959 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01006467001 26211204 26221959 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01035881001 5211280 5215609 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01037954001 11506476 11510357 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01037954001 11506476 11510357 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01010766001 22398355 22406939 GSVIVG01028040001 3356154 3358272 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Stops, prevents or reduces the activity of an enzyme. IEA GO:0004857 enzyme inhibitor activity GSVIVG01028040001 3356154 3358272 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the reaction: pectin + n H2O = n methanol + pectate. IEA GO:0030599 pectinesterase activity GSVIVG01016425001 4055455 4065247 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01025523001 14345398 14351618 GSVIVG01004109001 14885860 14908877 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01030410001 5334457 5354456 GSVIVG01001171001 1085630 1086572 GSVIVG01031648001 19594658 19600379 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01014463001 4097211 4097885 GSVIVG01009677001 10370553 10376406 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01009677001 10370553 10376406 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01009677001 10370553 10376406 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01009677001 10370553 10376406 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01009751001 10974284 10985490 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01023754001 10652892 10653258 GSVIVG01019865001 3979435 3982809 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GSVIVG01003431001 14952294 14954822 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01003431001 14952294 14954822 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01003431001 14952294 14954822 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01003431001 14952294 14954822 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01003431001 14952294 14954822 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01003431001 14952294 14954822 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01003431001 14952294 14954822 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01003431001 14952294 14954822 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01007128001 30259066 30259302 GSVIVG01013377001 838799 839349 GSVIVG01020254001 22213703 22228306 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01020254001 22213703 22228306 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nucleotidyl group to a reactant. IEA GO:0016779 nucleotidyltransferase activity GSVIVG01022880001 18474867 18475942 GSVIVG01030778001 15833139 15834425 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01008265001 3817694 3819382 Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01008265001 3817694 3819382 Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01008265001 3817694 3819382 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01008265001 3817694 3819382 Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01024391001 2006787 2007188 GSVIVG01006132001 41942399 41943970 GSVIVG01014081001 224299 234190 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014081001 224299 234190 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014081001 224299 234190 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli. IEA GO:0004707 MAP kinase activity GSVIVG01014081001 224299 234190 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014081001 224299 234190 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034368001 17354993 17356758 GSVIVG01018039001 5739315 5740456 GO:0019509 L-methionine salvage from methylthioadenosine The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01018039001 5739315 5740456 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01018039001 5739315 5740456 GO:0019509 L-methionine salvage from methylthioadenosine The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine. IEA Catalysis of the incorporation of both atoms of oxygen from one molecule of O2 into the (reduced) product(s) of the reaction. The two atoms of oxygen may be distributed between two different products. IEA GO:0051213 dioxygenase activity GSVIVG01018039001 5739315 5740456 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of both atoms of oxygen from one molecule of O2 into the (reduced) product(s) of the reaction. The two atoms of oxygen may be distributed between two different products. IEA GO:0051213 dioxygenase activity GSVIVG01037702001 7088027 7094310 GSVIVG01016780001 1296195 1297835 GSVIVG01033401001 20950334 20952488 GO:0006364 rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. IEA GO:0005732 small nucleolar ribonucleoprotein complex A ribonucleoprotein complex that contains a small nucleolar RNA (snoRNA) and associated proteins, and is found in eukaryotic cells. Most are involved in a step of processing of rRNA: cleavage, 2'-O-methylation, or pseudouridylation. The majority, though not all, fall into one of two classes, box C/D type or box H/ACA type. IEA Combining with a leukotriene to initiate a change in cell activity. Leukotrienes are pharmacologically active substances with a set of three conjugated double bonds; some contain a peptide moiety based on cysteine. IEA GO:0004974 leukotriene receptor activity GSVIVG01033401001 20950334 20952488 GO:0006364 rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with a leukotriene to initiate a change in cell activity. Leukotrienes are pharmacologically active substances with a set of three conjugated double bonds; some contain a peptide moiety based on cysteine. IEA GO:0004974 leukotriene receptor activity GSVIVG01033401001 20950334 20952488 GO:0006364 rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. IEA GO:0031429 box H/ACA snoRNP complex A ribonucleoprotein complex containing small nucleolar RNA of the box H/ACA type. IEA Combining with a leukotriene to initiate a change in cell activity. Leukotrienes are pharmacologically active substances with a set of three conjugated double bonds; some contain a peptide moiety based on cysteine. IEA GO:0004974 leukotriene receptor activity GSVIVG01033401001 20950334 20952488 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005732 small nucleolar ribonucleoprotein complex A ribonucleoprotein complex that contains a small nucleolar RNA (snoRNA) and associated proteins, and is found in eukaryotic cells. Most are involved in a step of processing of rRNA: cleavage, 2'-O-methylation, or pseudouridylation. The majority, though not all, fall into one of two classes, box C/D type or box H/ACA type. IEA Combining with a leukotriene to initiate a change in cell activity. Leukotrienes are pharmacologically active substances with a set of three conjugated double bonds; some contain a peptide moiety based on cysteine. IEA GO:0004974 leukotriene receptor activity GSVIVG01033401001 20950334 20952488 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with a leukotriene to initiate a change in cell activity. Leukotrienes are pharmacologically active substances with a set of three conjugated double bonds; some contain a peptide moiety based on cysteine. IEA GO:0004974 leukotriene receptor activity GSVIVG01033401001 20950334 20952488 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0031429 box H/ACA snoRNP complex A ribonucleoprotein complex containing small nucleolar RNA of the box H/ACA type. IEA Combining with a leukotriene to initiate a change in cell activity. Leukotrienes are pharmacologically active substances with a set of three conjugated double bonds; some contain a peptide moiety based on cysteine. IEA GO:0004974 leukotriene receptor activity GSVIVG01033401001 20950334 20952488 GO:0006364 rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. IEA GO:0005732 small nucleolar ribonucleoprotein complex A ribonucleoprotein complex that contains a small nucleolar RNA (snoRNA) and associated proteins, and is found in eukaryotic cells. Most are involved in a step of processing of rRNA: cleavage, 2'-O-methylation, or pseudouridylation. The majority, though not all, fall into one of two classes, box C/D type or box H/ACA type. IEA Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. IEA GO:0009982 pseudouridine synthase activity GSVIVG01033401001 20950334 20952488 GO:0006364 rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. IEA GO:0009982 pseudouridine synthase activity GSVIVG01033401001 20950334 20952488 GO:0006364 rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. IEA GO:0031429 box H/ACA snoRNP complex A ribonucleoprotein complex containing small nucleolar RNA of the box H/ACA type. IEA Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. IEA GO:0009982 pseudouridine synthase activity GSVIVG01033401001 20950334 20952488 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005732 small nucleolar ribonucleoprotein complex A ribonucleoprotein complex that contains a small nucleolar RNA (snoRNA) and associated proteins, and is found in eukaryotic cells. Most are involved in a step of processing of rRNA: cleavage, 2'-O-methylation, or pseudouridylation. The majority, though not all, fall into one of two classes, box C/D type or box H/ACA type. IEA Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. IEA GO:0009982 pseudouridine synthase activity GSVIVG01033401001 20950334 20952488 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. IEA GO:0009982 pseudouridine synthase activity GSVIVG01033401001 20950334 20952488 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0031429 box H/ACA snoRNP complex A ribonucleoprotein complex containing small nucleolar RNA of the box H/ACA type. IEA Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. IEA GO:0009982 pseudouridine synthase activity GSVIVG01033401001 20950334 20952488 GO:0006364 rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. IEA GO:0005732 small nucleolar ribonucleoprotein complex A ribonucleoprotein complex that contains a small nucleolar RNA (snoRNA) and associated proteins, and is found in eukaryotic cells. Most are involved in a step of processing of rRNA: cleavage, 2'-O-methylation, or pseudouridylation. The majority, though not all, fall into one of two classes, box C/D type or box H/ACA type. IEA Interacting selectively and non-covalently with ribosomal RNA. IEA GO:0019843 rRNA binding GSVIVG01033401001 20950334 20952488 GO:0006364 rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ribosomal RNA. IEA GO:0019843 rRNA binding GSVIVG01033401001 20950334 20952488 GO:0006364 rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. IEA GO:0031429 box H/ACA snoRNP complex A ribonucleoprotein complex containing small nucleolar RNA of the box H/ACA type. IEA Interacting selectively and non-covalently with ribosomal RNA. IEA GO:0019843 rRNA binding GSVIVG01033401001 20950334 20952488 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005732 small nucleolar ribonucleoprotein complex A ribonucleoprotein complex that contains a small nucleolar RNA (snoRNA) and associated proteins, and is found in eukaryotic cells. Most are involved in a step of processing of rRNA: cleavage, 2'-O-methylation, or pseudouridylation. The majority, though not all, fall into one of two classes, box C/D type or box H/ACA type. IEA Interacting selectively and non-covalently with ribosomal RNA. IEA GO:0019843 rRNA binding GSVIVG01033401001 20950334 20952488 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ribosomal RNA. IEA GO:0019843 rRNA binding GSVIVG01033401001 20950334 20952488 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0031429 box H/ACA snoRNP complex A ribonucleoprotein complex containing small nucleolar RNA of the box H/ACA type. IEA Interacting selectively and non-covalently with ribosomal RNA. IEA GO:0019843 rRNA binding GSVIVG01033401001 20950334 20952488 GO:0006364 rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. IEA GO:0005732 small nucleolar ribonucleoprotein complex A ribonucleoprotein complex that contains a small nucleolar RNA (snoRNA) and associated proteins, and is found in eukaryotic cells. Most are involved in a step of processing of rRNA: cleavage, 2'-O-methylation, or pseudouridylation. The majority, though not all, fall into one of two classes, box C/D type or box H/ACA type. IEA Interacting selectively and non-covalently with small nucleolar RNA. IEA GO:0030515 snoRNA binding GSVIVG01033401001 20950334 20952488 GO:0006364 rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with small nucleolar RNA. IEA GO:0030515 snoRNA binding GSVIVG01033401001 20950334 20952488 GO:0006364 rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. IEA GO:0031429 box H/ACA snoRNP complex A ribonucleoprotein complex containing small nucleolar RNA of the box H/ACA type. IEA Interacting selectively and non-covalently with small nucleolar RNA. IEA GO:0030515 snoRNA binding GSVIVG01033401001 20950334 20952488 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005732 small nucleolar ribonucleoprotein complex A ribonucleoprotein complex that contains a small nucleolar RNA (snoRNA) and associated proteins, and is found in eukaryotic cells. Most are involved in a step of processing of rRNA: cleavage, 2'-O-methylation, or pseudouridylation. The majority, though not all, fall into one of two classes, box C/D type or box H/ACA type. IEA Interacting selectively and non-covalently with small nucleolar RNA. IEA GO:0030515 snoRNA binding GSVIVG01033401001 20950334 20952488 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with small nucleolar RNA. IEA GO:0030515 snoRNA binding GSVIVG01033401001 20950334 20952488 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0031429 box H/ACA snoRNP complex A ribonucleoprotein complex containing small nucleolar RNA of the box H/ACA type. IEA Interacting selectively and non-covalently with small nucleolar RNA. IEA GO:0030515 snoRNA binding GSVIVG01006780001 268877 273048 GSVIVG01015054001 745937 751726 GSVIVG01008984001 4048720 4052933 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01008984001 4048720 4052933 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01008984001 4048720 4052933 GO:0008272 sulfate transport The directed movement of sulfate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01008984001 4048720 4052933 GO:0008272 sulfate transport The directed movement of sulfate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01008984001 4048720 4052933 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01008984001 4048720 4052933 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01008984001 4048720 4052933 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01008984001 4048720 4052933 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01008984001 4048720 4052933 GO:0008272 sulfate transport The directed movement of sulfate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01008984001 4048720 4052933 GO:0008272 sulfate transport The directed movement of sulfate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01008984001 4048720 4052933 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01008984001 4048720 4052933 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01028287001 5695820 5701697 GSVIVG01023264001 20425751 20443179 GSVIVG01002002001 6186163 6186602 GSVIVG01015464001 3938426 3949275 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01011409001 29437433 29443591 GO:0006189 'de novo' IMP biosynthetic process The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01011409001 29437433 29443591 GO:0006189 'de novo' IMP biosynthetic process The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole. IEA GO:0004641 phosphoribosylformylglycinamidine cyclo-ligase activity GSVIVG01012922001 13575609 13588502 Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides. IEA GO:0004866 endopeptidase inhibitor activity GSVIVG01016060001 18159868 18160299 GSVIVG01012383001 301575 303803 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012383001 301575 303803 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012383001 301575 303803 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01012383001 301575 303803 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01012383001 301575 303803 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01012383001 301575 303803 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01029079001 12014630 12073403 GO:0006749 glutathione metabolic process The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+. IEA GO:0004362 glutathione-disulfide reductase activity GSVIVG01029079001 12014630 12073403 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+. IEA GO:0004362 glutathione-disulfide reductase activity GSVIVG01029079001 12014630 12073403 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+. IEA GO:0004362 glutathione-disulfide reductase activity GSVIVG01029079001 12014630 12073403 GO:0006749 glutathione metabolic process The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01029079001 12014630 12073403 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01029079001 12014630 12073403 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01029079001 12014630 12073403 GO:0006749 glutathione metabolic process The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01029079001 12014630 12073403 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01029079001 12014630 12073403 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01029079001 12014630 12073403 GO:0006749 glutathione metabolic process The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01029079001 12014630 12073403 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01029079001 12014630 12073403 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01008796001 2174948 2177102 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01009652001 10220984 10224813 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01009652001 10220984 10224813 GO:0032259 methylation The process by which a methyl group is covalently attached to a molecule. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01009652001 10220984 10224813 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01009652001 10220984 10224813 GO:0032259 methylation The process by which a methyl group is covalently attached to a molecule. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01036794001 22472388 22474179 GSVIVG01015362001 2994473 3005520 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01018482001 14521450 14522282 GO:0043231 intracellular membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. IEA Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051537 2 iron, 2 sulfur cluster binding GSVIVG01006890001 28897820 28901690 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033940001 16541310 16569287 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01038629001 21346554 21349482 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038629001 21346554 21349482 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. IEA GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GSVIVG01007143001 30439226 30447469 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01007143001 30439226 30447469 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01007143001 30439226 30447469 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01007143001 30439226 30447469 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01007143001 30439226 30447469 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007143001 30439226 30447469 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007143001 30439226 30447469 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01007143001 30439226 30447469 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01011964001 2542528 2544985 GSVIVG01021373001 4613342 4614402 GSVIVG01023868001 2875914 2881812 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01023868001 2875914 2881812 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01023868001 2875914 2881812 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01023868001 2875914 2881812 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01023868001 2875914 2881812 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01023868001 2875914 2881812 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01023868001 2875914 2881812 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01023868001 2875914 2881812 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01037546001 11673249 11674737 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01010498001 21087967 21096140 GSVIVG01013176001 7100433 7117056 GSVIVG01028912001 17604161 17614162 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01028912001 17604161 17614162 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030130 clathrin coat of trans-Golgi network vesicle A clathrin coat found on a vesicle of the trans-Golgi network. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01028912001 17604161 17614162 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01028912001 17604161 17614162 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01028912001 17604161 17614162 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030130 clathrin coat of trans-Golgi network vesicle A clathrin coat found on a vesicle of the trans-Golgi network. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01028912001 17604161 17614162 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01028912001 17604161 17614162 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01028912001 17604161 17614162 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030130 clathrin coat of trans-Golgi network vesicle A clathrin coat found on a vesicle of the trans-Golgi network. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01028912001 17604161 17614162 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01028912001 17604161 17614162 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01028912001 17604161 17614162 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030130 clathrin coat of trans-Golgi network vesicle A clathrin coat found on a vesicle of the trans-Golgi network. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01028912001 17604161 17614162 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01028912001 17604161 17614162 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01028912001 17604161 17614162 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030130 clathrin coat of trans-Golgi network vesicle A clathrin coat found on a vesicle of the trans-Golgi network. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01028912001 17604161 17614162 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01028912001 17604161 17614162 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01028912001 17604161 17614162 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030130 clathrin coat of trans-Golgi network vesicle A clathrin coat found on a vesicle of the trans-Golgi network. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01028912001 17604161 17614162 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01028912001 17604161 17614162 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01028912001 17604161 17614162 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030130 clathrin coat of trans-Golgi network vesicle A clathrin coat found on a vesicle of the trans-Golgi network. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01028912001 17604161 17614162 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01028912001 17604161 17614162 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01028912001 17604161 17614162 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030130 clathrin coat of trans-Golgi network vesicle A clathrin coat found on a vesicle of the trans-Golgi network. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01028912001 17604161 17614162 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01027905001 9223137 9225933 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01027905001 9223137 9225933 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01025478001 490371 492894 GSVIVG01010807001 22843172 22845524 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: 3-alpha(S)-strictosidine = tryptamine + secologanin. IEA GO:0016844 strictosidine synthase activity GSVIVG01020079001 10598355 10600043 GSVIVG01026153001 13079562 13080178 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01026153001 13079562 13080178 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01026153001 13079562 13080178 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01026153001 13079562 13080178 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01024334001 1102688 1105211 GSVIVG01021337001 4236655 4238482 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01021337001 4236655 4238482 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01023797001 3408622 3411094 GSVIVG01013136001 7805765 7810149 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01013136001 7805765 7810149 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01027590001 15244253 15252325 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01027590001 15244253 15252325 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01027590001 15244253 15252325 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01027590001 15244253 15252325 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01011708001 4912273 4918899 GSVIVG01031259001 730735 731199 GSVIVG01031088001 2480364 2483982 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01025612001 13581905 13595846 GO:0009089 lysine biosynthetic process via diaminopimelate The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: LL-2,6-diaminoheptanedioate = meso-diaminoheptanedioate. IEA GO:0008837 diaminopimelate epimerase activity GSVIVG01021112001 1559545 1561633 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01021112001 1559545 1561633 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01022301001 18347880 18351117 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in). IEA GO:0005432 calcium:sodium antiporter activity GSVIVG01022301001 18347880 18351117 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in). IEA GO:0005432 calcium:sodium antiporter activity GSVIVG01022301001 18347880 18351117 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in). IEA GO:0005432 calcium:sodium antiporter activity GSVIVG01022301001 18347880 18351117 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in). IEA GO:0005432 calcium:sodium antiporter activity GSVIVG01024024001 1679498 1683271 GSVIVG01003856001 12914026 12921201 GO:0006544 glycine metabolic process The chemical reactions and pathways involving glycine, aminoethanoic acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003856001 12914026 12921201 GO:0006563 L-serine metabolic process The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003856001 12914026 12921201 GO:0006544 glycine metabolic process The chemical reactions and pathways involving glycine, aminoethanoic acid. IEA Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine. IEA GO:0004372 glycine hydroxymethyltransferase activity GSVIVG01003856001 12914026 12921201 GO:0006563 L-serine metabolic process The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. IEA Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine. IEA GO:0004372 glycine hydroxymethyltransferase activity GSVIVG01003856001 12914026 12921201 GO:0006544 glycine metabolic process The chemical reactions and pathways involving glycine, aminoethanoic acid. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01003856001 12914026 12921201 GO:0006563 L-serine metabolic process The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01000436001 7998716 7999327 GSVIVG01004865001 16197846 16201400 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025630001 13470515 13475648 GSVIVG01018018001 5509389 5511899 GSVIVG01020699001 3018560 3023114 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01034900001 16234068 16271237 GSVIVG01033179001 9019650 9026026 GSVIVG01028257001 4985116 4986839 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01021031001 15022475 15032692 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01021031001 15022475 15032692 GO:0042325 regulation of phosphorylation Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01021031001 15022475 15032692 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01021031001 15022475 15032692 GO:0042325 regulation of phosphorylation Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01021031001 15022475 15032692 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021031001 15022475 15032692 GO:0042325 regulation of phosphorylation Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035252001 11384824 11386846 GSVIVG01016922001 2576732 2603103 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01016922001 2576732 2603103 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01016922001 2576732 2603103 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01016922001 2576732 2603103 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016922001 2576732 2603103 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032187001 21738595 21739567 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01036515001 22952409 22954035 GSVIVG01012300001 13204794 13220780 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012300001 13204794 13220780 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01036525001 23056545 23058566 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01002376001 34454772 34456869 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01002376001 34454772 34456869 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01002376001 34454772 34456869 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01002376001 34454772 34456869 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01016000001 17149911 17153090 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035632001 2863082 2866487 GSVIVG01034995001 768916 769818 GSVIVG01020838001 1253357 1253784 GSVIVG01003298001 14317972 14332311 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01017242001 5833090 5835552 GSVIVG01031692001 20260089 20261162 GSVIVG01038637001 21294629 21295918 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01038637001 21294629 21295918 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01038637001 21294629 21295918 GO:0006414 translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01038637001 21294629 21295918 GO:0006414 translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01004116001 15011978 15020181 GO:0006364 rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01014138001 719037 726465 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014138001 719037 726465 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014138001 719037 726465 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014138001 719037 726465 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014138001 719037 726465 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018250001 12530762 12537200 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GSVIVG01019096001 16765755 16766066 GSVIVG01030413001 5375855 5388247 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030413001 5375855 5388247 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01033733001 18265208 18269207 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01031375001 19410537 19425212 GO:0016575 histone deacetylation The modification of histones by removal of acetyl groups. IEA Catalysis of the hydrolysis of acetyl groups from histones, proteins complexed to DNA in chromatin and chromosomes. IEA GO:0004407 histone deacetylase activity GSVIVG01009117001 5173364 5218160 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01009117001 5173364 5218160 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01000906001 21766671 21769961 GSVIVG01027213001 18114724 18198752 GSVIVG01030010001 8918654 8919134 GSVIVG01011486001 29985886 29991984 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. IEA GO:0004725 protein tyrosine phosphatase activity GSVIVG01011486001 29985886 29991984 GO:0016311 dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. IEA Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. IEA GO:0004725 protein tyrosine phosphatase activity GSVIVG01011486001 29985886 29991984 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA Catalysis of the reaction: protein serine/threonine/tyrosine phosphate + H2O = protein serine/threonine/tyrosine + phosphate. IEA GO:0008138 protein tyrosine/serine/threonine phosphatase activity GSVIVG01011486001 29985886 29991984 GO:0016311 dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. IEA Catalysis of the reaction: protein serine/threonine/tyrosine phosphate + H2O = protein serine/threonine/tyrosine + phosphate. IEA GO:0008138 protein tyrosine/serine/threonine phosphatase activity GSVIVG01011486001 29985886 29991984 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. IEA GO:0016791 phosphatase activity GSVIVG01011486001 29985886 29991984 GO:0016311 dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. IEA Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. IEA GO:0016791 phosphatase activity GSVIVG01021889001 5991570 5996164 GSVIVG01038735001 108594 119732 GSVIVG01031809001 4601055 4617416 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01031809001 4601055 4617416 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01031809001 4601055 4617416 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01031809001 4601055 4617416 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01031809001 4601055 4617416 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate. IEA GO:0003774 motor activity GSVIVG01031809001 4601055 4617416 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate. IEA GO:0003774 motor activity GSVIVG01031809001 4601055 4617416 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate. IEA GO:0003774 motor activity GSVIVG01031809001 4601055 4617416 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate. IEA GO:0003774 motor activity GSVIVG01031809001 4601055 4617416 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01031809001 4601055 4617416 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01031809001 4601055 4617416 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01031809001 4601055 4617416 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01031809001 4601055 4617416 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031809001 4601055 4617416 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031809001 4601055 4617416 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031809001 4601055 4617416 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031809001 4601055 4617416 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01031809001 4601055 4617416 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01031809001 4601055 4617416 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01031809001 4601055 4617416 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01021249001 2950028 2965500 GSVIVG01033765001 18015431 18020188 GO:0006955 immune response Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01033765001 18015431 18020188 GO:0006955 immune response Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with the tumor necrosis factor receptor. IEA GO:0005164 tumor necrosis factor receptor binding GSVIVG01023238001 20776918 20788534 GSVIVG01033173001 8913225 8913872 GSVIVG01026437001 23629551 23631317 GSVIVG01025649001 13314984 13317585 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01025649001 13314984 13317585 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01025649001 13314984 13317585 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025649001 13314984 13317585 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01005660001 20886259 20889358 GSVIVG01014337001 2760837 2762169 GO:0006829 zinc ion transport The directed movement of zinc (Zn) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. IEA GO:0005385 zinc ion transmembrane transporter activity GSVIVG01014337001 2760837 2762169 GO:0006829 zinc ion transport The directed movement of zinc (Zn) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. IEA GO:0005385 zinc ion transmembrane transporter activity GSVIVG01014337001 2760837 2762169 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. IEA GO:0005385 zinc ion transmembrane transporter activity GSVIVG01014337001 2760837 2762169 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. IEA GO:0005385 zinc ion transmembrane transporter activity GSVIVG01014337001 2760837 2762169 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. IEA GO:0005385 zinc ion transmembrane transporter activity GSVIVG01014337001 2760837 2762169 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. IEA GO:0005385 zinc ion transmembrane transporter activity GSVIVG01014337001 2760837 2762169 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. IEA GO:0005385 zinc ion transmembrane transporter activity GSVIVG01014337001 2760837 2762169 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. IEA GO:0005385 zinc ion transmembrane transporter activity GSVIVG01014337001 2760837 2762169 GO:0006829 zinc ion transport The directed movement of zinc (Zn) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01014337001 2760837 2762169 GO:0006829 zinc ion transport The directed movement of zinc (Zn) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01014337001 2760837 2762169 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01014337001 2760837 2762169 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01014337001 2760837 2762169 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01014337001 2760837 2762169 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01014337001 2760837 2762169 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01014337001 2760837 2762169 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01014337001 2760837 2762169 GO:0006829 zinc ion transport The directed movement of zinc (Zn) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01014337001 2760837 2762169 GO:0006829 zinc ion transport The directed movement of zinc (Zn) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01014337001 2760837 2762169 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01014337001 2760837 2762169 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01014337001 2760837 2762169 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01014337001 2760837 2762169 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01014337001 2760837 2762169 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01014337001 2760837 2762169 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01023269001 20406141 20407973 GSVIVG01017631001 2147655 2150249 GSVIVG01029591001 20995473 21007371 GO:0016068 type I hypersensitivity An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells or basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01007577001 11757261 11766550 GSVIVG01011382001 29211112 29213055 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01011382001 29211112 29213055 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01011382001 29211112 29213055 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01011382001 29211112 29213055 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01011382001 29211112 29213055 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01011382001 29211112 29213055 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01011382001 29211112 29213055 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01011382001 29211112 29213055 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01011382001 29211112 29213055 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01011382001 29211112 29213055 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01011382001 29211112 29213055 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01011382001 29211112 29213055 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01011382001 29211112 29213055 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01011382001 29211112 29213055 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01011382001 29211112 29213055 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01011382001 29211112 29213055 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01011382001 29211112 29213055 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01011382001 29211112 29213055 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01011382001 29211112 29213055 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01011382001 29211112 29213055 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01011382001 29211112 29213055 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01011382001 29211112 29213055 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01011382001 29211112 29213055 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01011382001 29211112 29213055 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01011382001 29211112 29213055 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01011382001 29211112 29213055 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01011382001 29211112 29213055 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01028654001 11645436 11646245 Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01028654001 11645436 11646245 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01031132001 1857144 1870475 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01031132001 1857144 1870475 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01031132001 1857144 1870475 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01013146001 7590222 7619311 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01013146001 7590222 7619311 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01001060001 7184833 7185988 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01001060001 7184833 7185988 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01001060001 7184833 7185988 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01001060001 7184833 7185988 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023200001 21217798 21230283 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01033747001 18157983 18166269 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01033747001 18157983 18166269 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033747001 18157983 18166269 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the reaction: ATP + pyruvate = ADP + phosphoenolpyruvate. IEA GO:0004743 pyruvate kinase activity GSVIVG01033747001 18157983 18166269 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Interacting selectively and non-covalently with potassium (K+) ions. IEA GO:0030955 potassium ion binding GSVIVG01025673001 13034927 13039978 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01025741001 12318124 12337827 GSVIVG01027459001 16573652 16582607 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01027459001 16573652 16582607 GO:0006796 phosphate metabolic process The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01027459001 16573652 16582607 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: diphosphate + H2O = 2 phosphate. IEA GO:0004427 inorganic diphosphatase activity GSVIVG01027459001 16573652 16582607 GO:0006796 phosphate metabolic process The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: diphosphate + H2O = 2 phosphate. IEA GO:0004427 inorganic diphosphatase activity GSVIVG01027459001 16573652 16582607 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01027459001 16573652 16582607 GO:0006796 phosphate metabolic process The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01027459001 16573652 16582607 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01027459001 16573652 16582607 GO:0006796 phosphate metabolic process The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01027459001 16573652 16582607 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01027459001 16573652 16582607 GO:0006796 phosphate metabolic process The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01027459001 16573652 16582607 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027459001 16573652 16582607 GO:0006796 phosphate metabolic process The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011619001 5854872 5917506 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01011619001 5854872 5917506 GO:0051260 protein homooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01009012001 4269303 4275210 GSVIVG01016377001 4363545 4366850 Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum. IEA GO:0003993 acid phosphatase activity GSVIVG01032683001 1562452 1569784 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01032683001 1562452 1569784 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01032683001 1562452 1569784 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01008244001 4166031 4174318 GSVIVG01000708001 3 43815 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000708001 3 43815 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000708001 3 43815 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000708001 3 43815 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01000708001 3 43815 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01000708001 3 43815 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01000708001 3 43815 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01000708001 3 43815 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01000708001 3 43815 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01021948001 5254285 5276945 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01021948001 5254285 5276945 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01021948001 5254285 5276945 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01021948001 5254285 5276945 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01021948001 5254285 5276945 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021948001 5254285 5276945 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021948001 5254285 5276945 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01021948001 5254285 5276945 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01013094001 8366139 8376971 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01013094001 8366139 8376971 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01013094001 8366139 8376971 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01013094001 8366139 8376971 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01013094001 8366139 8376971 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01013094001 8366139 8376971 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01017007001 3408608 3409659 GSVIVG01015819001 17875981 17882649 GO:0006546 glycine catabolic process The chemical reactions and pathways resulting in the breakdown of glycine, aminoethanoic acid. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA GSVIVG01015819001 17875981 17882649 GO:0006546 glycine catabolic process The chemical reactions and pathways resulting in the breakdown of glycine, aminoethanoic acid. IEA GO:0005960 glycine cleavage complex A protein complex that catalyzes the reversible oxidation of glycine. In E. coli, it has four components: dihydrolipoamide dehydrogenase, glycine dehydrogenase (decarboxylating), lipoyl-GcvH-protein and aminomethyltransferase, also known as L, P, H, and T. IEA GSVIVG01016290001 5509009 5517208 GO:0006541 glutamine metabolic process The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016290001 5509009 5517208 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016290001 5509009 5517208 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016290001 5509009 5517208 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016290001 5509009 5517208 GO:0009396 folic acid and derivative biosynthetic process The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016290001 5509009 5517208 GO:0006541 glutamine metabolic process The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate. IEA GO:0004049 anthranilate synthase activity GSVIVG01016290001 5509009 5517208 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate. IEA GO:0004049 anthranilate synthase activity GSVIVG01016290001 5509009 5517208 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate. IEA GO:0004049 anthranilate synthase activity GSVIVG01016290001 5509009 5517208 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate. IEA GO:0004049 anthranilate synthase activity GSVIVG01016290001 5509009 5517208 GO:0009396 folic acid and derivative biosynthetic process The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate. IEA GO:0004049 anthranilate synthase activity GSVIVG01016290001 5509009 5517208 GO:0006541 glutamine metabolic process The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01016290001 5509009 5517208 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01016290001 5509009 5517208 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01016290001 5509009 5517208 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01016290001 5509009 5517208 GO:0009396 folic acid and derivative biosynthetic process The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01016290001 5509009 5517208 GO:0006541 glutamine metabolic process The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the cleavage of a C-C bond by other means than by hydrolysis or oxidation, of a 3-hydroxy acid. IEA GO:0016833 oxo-acid-lyase activity GSVIVG01016290001 5509009 5517208 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the cleavage of a C-C bond by other means than by hydrolysis or oxidation, of a 3-hydroxy acid. IEA GO:0016833 oxo-acid-lyase activity GSVIVG01016290001 5509009 5517208 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the cleavage of a C-C bond by other means than by hydrolysis or oxidation, of a 3-hydroxy acid. IEA GO:0016833 oxo-acid-lyase activity GSVIVG01016290001 5509009 5517208 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the cleavage of a C-C bond by other means than by hydrolysis or oxidation, of a 3-hydroxy acid. IEA GO:0016833 oxo-acid-lyase activity GSVIVG01016290001 5509009 5517208 GO:0009396 folic acid and derivative biosynthetic process The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the cleavage of a C-C bond by other means than by hydrolysis or oxidation, of a 3-hydroxy acid. IEA GO:0016833 oxo-acid-lyase activity GSVIVG01033174001 8920373 8921014 GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA GSVIVG01016710001 531238 538224 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016710001 531238 538224 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016710001 531238 538224 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016710001 531238 538224 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01016710001 531238 538224 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01016710001 531238 538224 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01038322001 12875807 12876450 GSVIVG01027876001 8924447 8929184 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01012912001 13346703 13350089 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GSVIVG01034158001 14772451 14779005 GO:0008202 steroid metabolic process The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. IEA GSVIVG01019973001 12145163 12156877 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01019973001 12145163 12156877 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid. IEA GO:0008378 galactosyltransferase activity GSVIVG01011494001 30036278 30039256 GSVIVG01022629001 13761815 13769172 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01010289001 19095841 19096432 GSVIVG01030279001 9585100 9604900 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01030279001 9585100 9604900 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01030279001 9585100 9604900 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01030279001 9585100 9604900 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01034367001 17374537 17374695 GSVIVG01024161001 689247 690081 GSVIVG01029908001 1298951 1300396 GO:0009306 protein secretion The controlled release of proteins from a cell or group of cells. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01000651001 20421470 20425844 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01037715001 7211956 7217656 Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01037715001 7211956 7217656 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01037715001 7211956 7217656 Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01002655001 35709765 35713475 GSVIVG01008718001 1442920 1444351 GSVIVG01028859001 18039844 18041713 GSVIVG01012198001 605267 607892 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01012198001 605267 607892 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01012198001 605267 607892 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01012198001 605267 607892 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01018262001 12332039 12333772 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033985001 16104614 16108653 GSVIVG01035743001 3855437 3861860 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035743001 3855437 3861860 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01035743001 3855437 3861860 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01033568001 19698283 19701312 GO:0006278 RNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01033568001 19698283 19701312 GO:0006278 RNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. IEA Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time. IEA GO:0003964 RNA-directed DNA polymerase activity GSVIVG01006977001 29542184 29544169 GSVIVG01012206001 572047 573055 GSVIVG01026003001 25979171 26009592 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01026003001 25979171 26009592 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01026003001 25979171 26009592 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01026003001 25979171 26009592 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01026003001 25979171 26009592 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01026003001 25979171 26009592 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01026003001 25979171 26009592 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01026003001 25979171 26009592 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01026003001 25979171 26009592 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01026003001 25979171 26009592 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01026003001 25979171 26009592 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01026003001 25979171 26009592 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01026003001 25979171 26009592 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026003001 25979171 26009592 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026003001 25979171 26009592 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026003001 25979171 26009592 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026003001 25979171 26009592 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01026003001 25979171 26009592 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01026003001 25979171 26009592 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01026003001 25979171 26009592 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01021252001 3008687 3010451 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01021252001 3008687 3010451 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01001572001 351062 364489 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005643 nuclear pore Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined. IEA The action of a molecule that contributes to the structural integrity of the nuclear pore complex. IEA GO:0017056 structural constituent of nuclear pore GSVIVG01003669001 11952758 11967611 GSVIVG01015093001 973655 978109 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015093001 973655 978109 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0010181 FMN binding GSVIVG01015093001 973655 978109 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01017426001 8351257 8355068 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017426001 8351257 8355068 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01002010001 32235362 32244298 Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01002010001 32235362 32244298 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01032000001 23664299 23667469 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032000001 23664299 23667469 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032000001 23664299 23667469 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032000001 23664299 23667469 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016788001 1372818 1380307 GSVIVG01005754001 21842574 21850017 GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA GSVIVG01020364001 20530060 20530320 GSVIVG01005272001 20117372 20121415 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01005272001 20117372 20121415 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01031089001 2475206 2475649 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01031089001 2475206 2475649 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01031089001 2475206 2475649 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01031089001 2475206 2475649 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01007823001 8688131 8688720 GSVIVG01026357001 14878675 14882905 GSVIVG01022292001 18289282 18294356 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01022292001 18289282 18294356 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01022292001 18289282 18294356 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01022292001 18289282 18294356 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01022292001 18289282 18294356 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024191001 462583 465475 GSVIVG01025862001 11091328 11098640 GSVIVG01011386001 29249091 29252798 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01034176001 14615672 14618320 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01004972001 17194244 17194853 GO:0042773 ATP synthesis coupled electron transport The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP. IEA Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. IEA GO:0008137 NADH dehydrogenase (ubiquinone) activity GSVIVG01004972001 17194244 17194853 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. IEA GO:0008137 NADH dehydrogenase (ubiquinone) activity GSVIVG01024894001 6196821 6197527 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024894001 6196821 6197527 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024894001 6196821 6197527 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024894001 6196821 6197527 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024894001 6196821 6197527 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024894001 6196821 6197527 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024894001 6196821 6197527 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01024894001 6196821 6197527 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01024894001 6196821 6197527 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01024894001 6196821 6197527 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024894001 6196821 6197527 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024894001 6196821 6197527 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024506001 3479062 3479707 GSVIVG01035804001 4516354 4521501 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01035804001 4516354 4521501 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01035804001 4516354 4521501 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01035804001 4516354 4521501 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01035804001 4516354 4521501 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01035804001 4516354 4521501 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035804001 4516354 4521501 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035804001 4516354 4521501 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035804001 4516354 4521501 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035804001 4516354 4521501 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035804001 4516354 4521501 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01035804001 4516354 4521501 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01035804001 4516354 4521501 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01035804001 4516354 4521501 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01035804001 4516354 4521501 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01015616001 14121437 14132378 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015616001 14121437 14132378 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01015616001 14121437 14132378 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01020167001 9503470 9506746 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01027599001 15163557 15169866 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01027599001 15163557 15169866 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027599001 15163557 15169866 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids. IEA GO:0004518 nuclease activity GSVIVG01028713001 19512908 19514934 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01021194001 2463271 2471773 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004197 cysteine-type endopeptidase activity GSVIVG01021194001 2463271 2471773 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01029242001 18133595 18136869 GO:0016226 iron-sulfur cluster assembly The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01029242001 18133595 18136869 GO:0016226 iron-sulfur cluster assembly The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01007239001 31021936 31033101 GSVIVG01017184001 5099104 5114849 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01017184001 5099104 5114849 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017184001 5099104 5114849 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01017184001 5099104 5114849 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01022091001 16512496 16512879 GSVIVG01002785001 36414831 36415944 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01002785001 36414831 36415944 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01021833001 6728579 6754351 GO:0001522 pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01021833001 6728579 6754351 GO:0009451 RNA modification The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01021833001 6728579 6754351 GO:0001522 pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs. IEA Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. IEA GO:0009982 pseudouridine synthase activity GSVIVG01021833001 6728579 6754351 GO:0009451 RNA modification The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. IEA Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. IEA GO:0009982 pseudouridine synthase activity GSVIVG01037921001 6338114 6339894 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01015436001 3667387 3671975 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion. IEA GO:0005484 SNAP receptor activity GSVIVG01015436001 3667387 3671975 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion. IEA GO:0005484 SNAP receptor activity GSVIVG01015436001 3667387 3671975 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01015436001 3667387 3671975 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031924001 5438363 5441985 GSVIVG01029587001 21076318 21079858 GSVIVG01013197001 6860937 6867964 GSVIVG01014643001 8128770 8134567 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01014643001 8128770 8134567 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01014643001 8128770 8134567 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01002637001 35565847 35572566 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01002637001 35565847 35572566 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036098001 20720592 20721218 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with manganese (Mn) ions. IEA GO:0030145 manganese ion binding GSVIVG01036098001 20720592 20721218 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Functions in the storage of nutritious substrates. IEA GO:0045735 nutrient reservoir activity GSVIVG01036098001 20720592 20721218 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01025012001 5298004 5302204 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025012001 5298004 5302204 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025012001 5298004 5302204 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025012001 5298004 5302204 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025012001 5298004 5302204 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01025012001 5298004 5302204 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01025012001 5298004 5302204 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025012001 5298004 5302204 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021934001 5471198 5471359 GSVIVG01001721001 514889 516678 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001721001 514889 516678 Catalysis of the transfer of a functional group from one position to another within a single molecule. IEA GO:0016866 intramolecular transferase activity GSVIVG01035036001 1068311 1072981 GSVIVG01012100001 1500586 1504450 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01012100001 1500586 1504450 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01012100001 1500586 1504450 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01012100001 1500586 1504450 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01019757001 3026097 3044552 GO:0006750 glutathione biosynthetic process The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins. IEA Catalysis of the reaction: ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine. IEA GO:0004357 glutamate-cysteine ligase activity GSVIVG01002816001 36716044 36717292 GSVIVG01013410001 635351 641071 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of the reaction: dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by glycosylamine linkage to protein L-asparagine. IEA GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity GSVIVG01013410001 635351 641071 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by glycosylamine linkage to protein L-asparagine. IEA GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity GSVIVG01003466001 10535485 10537687 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with transfer RNA. IEA GO:0000049 tRNA binding GSVIVG01003466001 10535485 10537687 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe). IEA GO:0004826 phenylalanine-tRNA ligase activity GSVIVG01003466001 10535485 10537687 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037459001 13328667 13329717 GSVIVG01019881001 4176705 4190754 GSVIVG01031884001 5149605 5150096 GSVIVG01014965001 13176930 13186647 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01014965001 13176930 13186647 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01014965001 13176930 13186647 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01014965001 13176930 13186647 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01037005001 9044693 9045211 GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA GSVIVG01020720001 2724787 2768223 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: cysteamine + O2 = hypotaurine. IEA GO:0047800 cysteamine dioxygenase activity GSVIVG01026950001 19140742 19142113 GSVIVG01036550001 23353154 23356778 GSVIVG01007149001 5400661 5409494 GO:0006464 protein modification process The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). IEA Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein. IEA GO:0008474 palmitoyl-(protein) hydrolase activity GSVIVG01023149001 21939959 21950048 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01023149001 21939959 21950048 GO:0009725 response to hormone stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01023149001 21939959 21950048 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01023149001 21939959 21950048 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01023149001 21939959 21950048 GO:0009725 response to hormone stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01023149001 21939959 21950048 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01021751001 10522533 10522948 GSVIVG01022669001 14386733 14387420 GSVIVG01037859001 7051150 7055710 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 4 R'C(R)SH + O2 = 2 R'C(R)S-S(R)CR' + 2 H2O. IEA GO:0016972 thiol oxidase activity GSVIVG01034124001 15000530 15007709 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017091001 4100236 4102196 GSVIVG01007477001 32167793 32169504 GSVIVG01029749001 14127382 14132040 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004185 serine-type carboxypeptidase activity GSVIVG01008185001 4910754 4920747 GO:0009446 putrescine biosynthetic process The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane; putrescine can be synthesized from arginine or ornithine and is the metabolic precursor of spermidine and spermine. IEA Catalysis of the reaction: agmatine + H2O = N-carbamoylputrescine + NH3. IEA GO:0047632 agmatine deiminase activity GSVIVG01033131001 8149430 8183352 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01033131001 8149430 8183352 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01033131001 8149430 8183352 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01033131001 8149430 8183352 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01033131001 8149430 8183352 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01033131001 8149430 8183352 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01033131001 8149430 8183352 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01033131001 8149430 8183352 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01033131001 8149430 8183352 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01033131001 8149430 8183352 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01033131001 8149430 8183352 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01033131001 8149430 8183352 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01033131001 8149430 8183352 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01033131001 8149430 8183352 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01033131001 8149430 8183352 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01033131001 8149430 8183352 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01033131001 8149430 8183352 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01033131001 8149430 8183352 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01033131001 8149430 8183352 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033131001 8149430 8183352 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033131001 8149430 8183352 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033131001 8149430 8183352 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033131001 8149430 8183352 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033131001 8149430 8183352 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033131001 8149430 8183352 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033131001 8149430 8183352 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033131001 8149430 8183352 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033131001 8149430 8183352 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033131001 8149430 8183352 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033131001 8149430 8183352 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033131001 8149430 8183352 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033131001 8149430 8183352 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033131001 8149430 8183352 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033131001 8149430 8183352 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033131001 8149430 8183352 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033131001 8149430 8183352 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033131001 8149430 8183352 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01033131001 8149430 8183352 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01033131001 8149430 8183352 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01033131001 8149430 8183352 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01033131001 8149430 8183352 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01033131001 8149430 8183352 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01033131001 8149430 8183352 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01033131001 8149430 8183352 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01033131001 8149430 8183352 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01033131001 8149430 8183352 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01033131001 8149430 8183352 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01033131001 8149430 8183352 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01033131001 8149430 8183352 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01033131001 8149430 8183352 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01033131001 8149430 8183352 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01033131001 8149430 8183352 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01033131001 8149430 8183352 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01033131001 8149430 8183352 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01017220001 5593272 5594288 GSVIVG01017958001 5082857 5085083 GO:0009308 amine metabolic process The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01017958001 5082857 5085083 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01017958001 5082857 5085083 GO:0009308 amine metabolic process The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. IEA Catalysis of the reaction: R-CH2-NH2 + H2O + O2 = R-CHO + NH3 + H2O2. IEA GO:0008131 amine oxidase activity GSVIVG01017958001 5082857 5085083 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: R-CH2-NH2 + H2O + O2 = R-CHO + NH3 + H2O2. IEA GO:0008131 amine oxidase activity GSVIVG01017958001 5082857 5085083 GO:0009308 amine metabolic process The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01017958001 5082857 5085083 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01017958001 5082857 5085083 GO:0009308 amine metabolic process The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01017958001 5082857 5085083 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01017958001 5082857 5085083 GO:0009308 amine metabolic process The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. IEA Interacting selectively and non-covalently with a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds. IEA GO:0048038 quinone binding GSVIVG01017958001 5082857 5085083 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds. IEA GO:0048038 quinone binding GSVIVG01021513001 6434032 6445844 GSVIVG01020071001 10805860 10813853 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01001079001 22419938 22442311 GO:0032312 regulation of ARF GTPase activity Any process that modulates the activity of the GTPase ARF. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01001079001 22419938 22442311 GO:0032312 regulation of ARF GTPase activity Any process that modulates the activity of the GTPase ARF. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Increases the rate of GTP hydrolysis by the GTPase ARF. IEA GO:0008060 ARF GTPase activator activity GSVIVG01001079001 22419938 22442311 GO:0032312 regulation of ARF GTPase activity Any process that modulates the activity of the GTPase ARF. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01036624001 19314808 19315804 GSVIVG01033788001 17824016 17829368 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01033788001 17824016 17829368 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01030164001 10911783 10916791 GSVIVG01037307001 16088894 16088998 GSVIVG01006373001 25336571 25338787 GSVIVG01009921001 12403268 12404134 Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01010541001 16807567 16809744 GSVIVG01011553001 12280962 12281208 GSVIVG01012156001 979380 981773 GSVIVG01025200001 3387040 3425617 GSVIVG01019849001 3822830 3825957 GSVIVG01026351001 14621965 14683043 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01030976001 20163056 20163701 GSVIVG01030078001 9633646 9635733 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01024437001 2531630 2534120 GSVIVG01021456001 5571704 5574526 GSVIVG01003308001 8876219 8878523 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01003308001 8876219 8878523 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01031214001 1120759 1126570 GSVIVG01012866001 6357129 6362911 GSVIVG01025452001 744520 745772 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025033001 5115687 5118539 GO:0009396 folic acid and derivative biosynthetic process The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010839001 23250771 23262877 GSVIVG01029520001 22019302 22025424 GSVIVG01029248001 18043160 18045625 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027306001 16912760 16915117 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027306001 16912760 16915117 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027306001 16912760 16915117 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027306001 16912760 16915117 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027306001 16912760 16915117 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01027306001 16912760 16915117 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01015813001 17775738 17787000 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01015813001 17775738 17787000 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01015813001 17775738 17787000 GO:0006423 cysteinyl-tRNA aminoacylation The process of coupling cysteine to cysteinyl-tRNA, catalyzed by cysteinyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01015813001 17775738 17787000 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01015813001 17775738 17787000 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01015813001 17775738 17787000 GO:0006423 cysteinyl-tRNA aminoacylation The process of coupling cysteine to cysteinyl-tRNA, catalyzed by cysteinyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01015813001 17775738 17787000 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys). IEA GO:0004817 cysteine-tRNA ligase activity GSVIVG01015813001 17775738 17787000 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys). IEA GO:0004817 cysteine-tRNA ligase activity GSVIVG01015813001 17775738 17787000 GO:0006423 cysteinyl-tRNA aminoacylation The process of coupling cysteine to cysteinyl-tRNA, catalyzed by cysteinyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys). IEA GO:0004817 cysteine-tRNA ligase activity GSVIVG01015813001 17775738 17787000 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015813001 17775738 17787000 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015813001 17775738 17787000 GO:0006423 cysteinyl-tRNA aminoacylation The process of coupling cysteine to cysteinyl-tRNA, catalyzed by cysteinyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023867001 2885253 2887990 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01023867001 2885253 2887990 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01023867001 2885253 2887990 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01023867001 2885253 2887990 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01023867001 2885253 2887990 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01023867001 2885253 2887990 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01023867001 2885253 2887990 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01023867001 2885253 2887990 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01023867001 2885253 2887990 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01023867001 2885253 2887990 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01023867001 2885253 2887990 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01023867001 2885253 2887990 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033944001 16453087 16455302 GSVIVG01012559001 3576063 3576810 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009618001 9925359 9928347 GSVIVG01027207001 18282059 18291699 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01027207001 18282059 18291699 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01027207001 18282059 18291699 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01027207001 18282059 18291699 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01027207001 18282059 18291699 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01027207001 18282059 18291699 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01027207001 18282059 18291699 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027207001 18282059 18291699 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027207001 18282059 18291699 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027207001 18282059 18291699 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027207001 18282059 18291699 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027207001 18282059 18291699 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027207001 18282059 18291699 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the movement of phospholipids from one membrane face to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP. IEA GO:0004012 phospholipid-translocating ATPase activity GSVIVG01027207001 18282059 18291699 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the movement of phospholipids from one membrane face to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP. IEA GO:0004012 phospholipid-translocating ATPase activity GSVIVG01027207001 18282059 18291699 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the movement of phospholipids from one membrane face to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP. IEA GO:0004012 phospholipid-translocating ATPase activity GSVIVG01027207001 18282059 18291699 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the movement of phospholipids from one membrane face to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP. IEA GO:0004012 phospholipid-translocating ATPase activity GSVIVG01027207001 18282059 18291699 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the movement of phospholipids from one membrane face to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP. IEA GO:0004012 phospholipid-translocating ATPase activity GSVIVG01027207001 18282059 18291699 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the movement of phospholipids from one membrane face to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP. IEA GO:0004012 phospholipid-translocating ATPase activity GSVIVG01027207001 18282059 18291699 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027207001 18282059 18291699 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027207001 18282059 18291699 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027207001 18282059 18291699 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027207001 18282059 18291699 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027207001 18282059 18291699 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027207001 18282059 18291699 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01027207001 18282059 18291699 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01027207001 18282059 18291699 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01027207001 18282059 18291699 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01027207001 18282059 18291699 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01027207001 18282059 18291699 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01027207001 18282059 18291699 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01027207001 18282059 18291699 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01027207001 18282059 18291699 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01027207001 18282059 18291699 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01027207001 18282059 18291699 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01027207001 18282059 18291699 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01022795001 16680944 16682001 GSVIVG01009388001 7942170 7953201 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01009388001 7942170 7953201 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01009388001 7942170 7953201 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01009388001 7942170 7953201 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01021397001 4894476 4896340 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01021397001 4894476 4896340 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01021397001 4894476 4896340 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01021397001 4894476 4896340 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01021397001 4894476 4896340 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01021397001 4894476 4896340 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01017929001 4794317 4798309 GSVIVG01020657001 3371879 3373415 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004197 cysteine-type endopeptidase activity GSVIVG01020657001 3371879 3373415 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01033660001 18848361 18859961 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033660001 18848361 18859961 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01005823001 268307 268771 GSVIVG01025282001 2452759 2472297 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025282001 2452759 2472297 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01025282001 2452759 2472297 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01025282001 2452759 2472297 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025282001 2452759 2472297 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01025282001 2452759 2472297 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01025282001 2452759 2472297 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01022342001 18710375 18723402 GO:0006342 chromatin silencing Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01022342001 18710375 18723402 GO:0006476 protein amino acid deacetylation The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01022342001 18710375 18723402 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01022342001 18710375 18723402 GO:0006342 chromatin silencing Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin. IEA Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide. IEA GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides GSVIVG01022342001 18710375 18723402 GO:0006476 protein amino acid deacetylation The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid. IEA Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide. IEA GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides GSVIVG01022342001 18710375 18723402 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide. IEA GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides GSVIVG01022342001 18710375 18723402 GO:0006342 chromatin silencing Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin. IEA Interacting selectively and non-covalently with the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions. IEA GO:0070403 NAD binding GSVIVG01022342001 18710375 18723402 GO:0006476 protein amino acid deacetylation The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid. IEA Interacting selectively and non-covalently with the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions. IEA GO:0070403 NAD binding GSVIVG01022342001 18710375 18723402 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions. IEA GO:0070403 NAD binding GSVIVG01036437001 5145739 5151236 GO:0006400 tRNA modification The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically. IEA Catalysis of the reaction: tRNA guanine + queuine = tRNA queuine + guanine. IEA GO:0008479 queuine tRNA-ribosyltransferase activity GSVIVG01036437001 5145739 5151236 GO:0008616 queuosine biosynthetic process The chemical reactions and pathways resulting in the formation of queuosines, any of a series of nucleosides found in tRNA and having an additional pentenyl ring added via an NH group to the methyl group of 7-methylguanosine. The pentenyl ring may carry other substituents. IEA Catalysis of the reaction: tRNA guanine + queuine = tRNA queuine + guanine. IEA GO:0008479 queuine tRNA-ribosyltransferase activity GSVIVG01010627001 15857462 15861283 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01010627001 15857462 15861283 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01010627001 15857462 15861283 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01010627001 15857462 15861283 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01010627001 15857462 15861283 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01010627001 15857462 15861283 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01036913001 17738721 17744676 GO:0007010 cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01017896001 4462134 4463397 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01004807001 63908 71048 GSVIVG01018086001 6348745 6352561 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018086001 6348745 6352561 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018086001 6348745 6352561 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01018086001 6348745 6352561 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01018086001 6348745 6352561 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01018086001 6348745 6352561 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01020250001 22256470 22257340 GSVIVG01020941001 16809335 16809508 GSVIVG01017769001 3307669 3310267 GSVIVG01011612001 5989546 5998606 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01011612001 5989546 5998606 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01011612001 5989546 5998606 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01011612001 5989546 5998606 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01011612001 5989546 5998606 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01011612001 5989546 5998606 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01011612001 5989546 5998606 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01011612001 5989546 5998606 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01011612001 5989546 5998606 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01011612001 5989546 5998606 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01011612001 5989546 5998606 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01011612001 5989546 5998606 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01011612001 5989546 5998606 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01011612001 5989546 5998606 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01011612001 5989546 5998606 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01011612001 5989546 5998606 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01011612001 5989546 5998606 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01011612001 5989546 5998606 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01011612001 5989546 5998606 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01011612001 5989546 5998606 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01011612001 5989546 5998606 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011612001 5989546 5998606 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011612001 5989546 5998606 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011612001 5989546 5998606 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011612001 5989546 5998606 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011612001 5989546 5998606 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01011612001 5989546 5998606 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01011612001 5989546 5998606 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01011612001 5989546 5998606 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01011612001 5989546 5998606 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01027990001 3032722 3040092 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01027990001 3032722 3040092 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01027990001 3032722 3040092 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027990001 3032722 3040092 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027990001 3032722 3040092 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01027990001 3032722 3040092 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01027990001 3032722 3040092 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01027990001 3032722 3040092 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01027990001 3032722 3040092 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01027990001 3032722 3040092 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01035942001 6257828 6258502 GSVIVG01026805001 7536947 7538035 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005643 nuclear pore Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined. IEA The action of a molecule that contributes to the structural integrity of the nuclear pore complex. IEA GO:0017056 structural constituent of nuclear pore GSVIVG01021594001 7733350 7752675 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01021594001 7733350 7752675 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01021594001 7733350 7752675 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021594001 7733350 7752675 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021594001 7733350 7752675 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01021594001 7733350 7752675 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01021594001 7733350 7752675 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01021594001 7733350 7752675 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01021594001 7733350 7752675 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01021594001 7733350 7752675 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01024834001 6544482 6550175 GSVIVG01028543001 9500565 9501380 GSVIVG01000378001 360669 360989 GSVIVG01016531001 3054537 3077620 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016531001 3054537 3077620 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016531001 3054537 3077620 GO:0006897 endocytosis A type of vesicle-mediated transport in which cells take up external materials or membrane constituents by the invagination of small region of the plasma membrane to form a new membrane-bounded vesicle. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016531001 3054537 3077620 GO:0006897 endocytosis A type of vesicle-mediated transport in which cells take up external materials or membrane constituents by the invagination of small region of the plasma membrane to form a new membrane-bounded vesicle. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016531001 3054537 3077620 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016531001 3054537 3077620 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016531001 3054537 3077620 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016531001 3054537 3077620 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016531001 3054537 3077620 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016531001 3054537 3077620 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016531001 3054537 3077620 GO:0006897 endocytosis A type of vesicle-mediated transport in which cells take up external materials or membrane constituents by the invagination of small region of the plasma membrane to form a new membrane-bounded vesicle. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016531001 3054537 3077620 GO:0006897 endocytosis A type of vesicle-mediated transport in which cells take up external materials or membrane constituents by the invagination of small region of the plasma membrane to form a new membrane-bounded vesicle. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016531001 3054537 3077620 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016531001 3054537 3077620 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016531001 3054537 3077620 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016531001 3054537 3077620 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016531001 3054537 3077620 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01016531001 3054537 3077620 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01016531001 3054537 3077620 GO:0006897 endocytosis A type of vesicle-mediated transport in which cells take up external materials or membrane constituents by the invagination of small region of the plasma membrane to form a new membrane-bounded vesicle. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01016531001 3054537 3077620 GO:0006897 endocytosis A type of vesicle-mediated transport in which cells take up external materials or membrane constituents by the invagination of small region of the plasma membrane to form a new membrane-bounded vesicle. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01016531001 3054537 3077620 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01016531001 3054537 3077620 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01016531001 3054537 3077620 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01016531001 3054537 3077620 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01004849001 14773 37243 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01004331001 38127865 38130467 GSVIVG01012277001 12949822 12950531 GO:0009060 aerobic respiration The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01012277001 12949822 12950531 GO:0009060 aerobic respiration The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01012277001 12949822 12950531 GO:0009060 aerobic respiration The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01008623001 333607 334551 GSVIVG01019263001 2399737 2401872 GSVIVG01035331001 541014 542532 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01035331001 541014 542532 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01028456001 7864045 7888017 GSVIVG01014488001 4374573 4374938 Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01014488001 4374573 4374938 Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01013509001 2009981 2012675 GSVIVG01030599001 7051966 7054966 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01030599001 7051966 7054966 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01030599001 7051966 7054966 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ribosomal RNA. IEA GO:0019843 rRNA binding GSVIVG01030599001 7051966 7054966 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with ribosomal RNA. IEA GO:0019843 rRNA binding GSVIVG01028051001 3452986 3455599 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01028051001 3452986 3455599 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01028051001 3452986 3455599 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01028051001 3452986 3455599 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01005635001 20762764 20769242 GSVIVG01011438001 29658122 29671060 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01011438001 29658122 29671060 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01011438001 29658122 29671060 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01011438001 29658122 29671060 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01011438001 29658122 29671060 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01011438001 29658122 29671060 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01023397001 12583680 12614451 GSVIVG01030526001 6477624 6486243 GSVIVG01006308001 24787971 24792138 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01006308001 24787971 24792138 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01006308001 24787971 24792138 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01006308001 24787971 24792138 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01006308001 24787971 24792138 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01006308001 24787971 24792138 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01006308001 24787971 24792138 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01006308001 24787971 24792138 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01012252001 112285 118695 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012252001 112285 118695 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01029007001 10611367 10626517 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01028650001 11590376 11593509 GSVIVG01007786001 9017132 9026798 GSVIVG01036430001 5050310 5053234 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01036430001 5050310 5053234 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01036430001 5050310 5053234 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01036430001 5050310 5053234 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01036430001 5050310 5053234 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01036430001 5050310 5053234 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01036430001 5050310 5053234 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01036430001 5050310 5053234 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01036430001 5050310 5053234 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01036430001 5050310 5053234 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01036430001 5050310 5053234 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01036430001 5050310 5053234 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01036430001 5050310 5053234 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01036430001 5050310 5053234 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01036430001 5050310 5053234 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01030187001 10715309 10721679 GSVIVG01013218001 6646932 6657662 Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01013218001 6646932 6657662 Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01025164001 3830035 3835134 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion. IEA GO:0005484 SNAP receptor activity GSVIVG01025164001 3830035 3835134 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion. IEA GO:0005484 SNAP receptor activity GSVIVG01025164001 3830035 3835134 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion. IEA GO:0005484 SNAP receptor activity GSVIVG01025164001 3830035 3835134 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion. IEA GO:0005484 SNAP receptor activity GSVIVG01025164001 3830035 3835134 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with a protein hormone to initiate a change in cell activity. IEA GO:0016500 protein-hormone receptor activity GSVIVG01025164001 3830035 3835134 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with a protein hormone to initiate a change in cell activity. IEA GO:0016500 protein-hormone receptor activity GSVIVG01025164001 3830035 3835134 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with a protein hormone to initiate a change in cell activity. IEA GO:0016500 protein-hormone receptor activity GSVIVG01025164001 3830035 3835134 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with a protein hormone to initiate a change in cell activity. IEA GO:0016500 protein-hormone receptor activity GSVIVG01005031001 17408022 17408806 GSVIVG01008841001 2677067 2684336 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005663 DNA replication factor C complex A complex of five polypeptides in eukaryotes, and two in prokaryotes, that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01008841001 2677067 2684336 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005663 DNA replication factor C complex A complex of five polypeptides in eukaryotes, and two in prokaryotes, that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01008841001 2677067 2684336 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005663 DNA replication factor C complex A complex of five polypeptides in eukaryotes, and two in prokaryotes, that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their closing around the DNA duplex. IEA GO:0003689 DNA clamp loader activity GSVIVG01008841001 2677067 2684336 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005663 DNA replication factor C complex A complex of five polypeptides in eukaryotes, and two in prokaryotes, that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008841001 2677067 2684336 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005663 DNA replication factor C complex A complex of five polypeptides in eukaryotes, and two in prokaryotes, that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01036657001 19924833 19928423 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036657001 19924833 19928423 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036657001 19924833 19928423 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036657001 19924833 19928423 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020486001 18593103 18595449 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01023901001 2585954 2587664 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01023901001 2585954 2587664 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01031198001 1251606 1255720 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031198001 1251606 1255720 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01024005001 1786700 1794856 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01024005001 1786700 1794856 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01003450001 10228441 10228821 GSVIVG01006720001 1236452 1242558 Catalysis of the removal of a phosphate group from phosphorylated myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol. IEA GO:0004437 inositol or phosphatidylinositol phosphatase activity GSVIVG01007540001 12479098 12494428 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01022961001 17549019 17552648 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01022961001 17549019 17552648 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01022961001 17549019 17552648 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01022961001 17549019 17552648 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01022961001 17549019 17552648 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022961001 17549019 17552648 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022961001 17549019 17552648 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01022961001 17549019 17552648 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01027642001 14759920 14767013 GSVIVG01019610001 1935459 1939794 GO:0005991 trehalose metabolic process The chemical reactions and pathways involving trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019610001 1935459 1939794 GO:0005991 trehalose metabolic process The chemical reactions and pathways involving trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi. IEA Catalysis of the reaction: alpha,alpha-trehalose + H2O = 2 D-glucose. IEA GO:0004555 alpha,alpha-trehalase activity GSVIVG01021422001 5177012 5177273 GSVIVG01024346001 1259814 1264248 GSVIVG01034494001 20396918 20422554 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01034494001 20396918 20422554 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01034494001 20396918 20422554 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016152001 19943990 19959083 GSVIVG01019122001 16545494 16553795 GSVIVG01035988001 6893303 6896204 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin. IEA GO:0004221 ubiquitin thiolesterase activity GSVIVG01035988001 6893303 6896204 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01019660001 2293459 2296287 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030071001 9541236 9580847 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032336001 15181231 15187509 GSVIVG01001746001 725404 726669 Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01027183001 17202805 17208814 GSVIVG01033809001 17604366 17606608 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01033809001 17604366 17606608 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01033809001 17604366 17606608 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01033809001 17604366 17606608 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01035951001 6381532 6389548 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01035951001 6381532 6389548 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01035951001 6381532 6389548 GO:0006423 cysteinyl-tRNA aminoacylation The process of coupling cysteine to cysteinyl-tRNA, catalyzed by cysteinyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01035951001 6381532 6389548 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01035951001 6381532 6389548 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01035951001 6381532 6389548 GO:0006423 cysteinyl-tRNA aminoacylation The process of coupling cysteine to cysteinyl-tRNA, catalyzed by cysteinyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01035951001 6381532 6389548 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys). IEA GO:0004817 cysteine-tRNA ligase activity GSVIVG01035951001 6381532 6389548 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys). IEA GO:0004817 cysteine-tRNA ligase activity GSVIVG01035951001 6381532 6389548 GO:0006423 cysteinyl-tRNA aminoacylation The process of coupling cysteine to cysteinyl-tRNA, catalyzed by cysteinyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys). IEA GO:0004817 cysteine-tRNA ligase activity GSVIVG01035951001 6381532 6389548 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035951001 6381532 6389548 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035951001 6381532 6389548 GO:0006423 cysteinyl-tRNA aminoacylation The process of coupling cysteine to cysteinyl-tRNA, catalyzed by cysteinyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012565001 3706074 3706481 GSVIVG01024012001 1749591 1753021 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024012001 1749591 1753021 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024012001 1749591 1753021 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01024012001 1749591 1753021 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. IEA GO:0048037 cofactor binding GSVIVG01024012001 1749591 1753021 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01038362001 13678136 13683905 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01015014001 443152 447398 GO:0006413 translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. IEA GO:0003743 translation initiation factor activity GSVIVG01015014001 443152 447398 GO:0006413 translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. IEA GO:0005852 eukaryotic translation initiation factor 3 complex A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs. IEA Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. IEA GO:0003743 translation initiation factor activity GSVIVG01015014001 443152 447398 GO:0006446 regulation of translational initiation Any process that modulates the frequency, rate or extent of translational initiation. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. IEA GO:0003743 translation initiation factor activity GSVIVG01015014001 443152 447398 GO:0006446 regulation of translational initiation Any process that modulates the frequency, rate or extent of translational initiation. IEA GO:0005852 eukaryotic translation initiation factor 3 complex A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs. IEA Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. IEA GO:0003743 translation initiation factor activity GSVIVG01015014001 443152 447398 GO:0006413 translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01015014001 443152 447398 GO:0006413 translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. IEA GO:0005852 eukaryotic translation initiation factor 3 complex A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01015014001 443152 447398 GO:0006446 regulation of translational initiation Any process that modulates the frequency, rate or extent of translational initiation. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01015014001 443152 447398 GO:0006446 regulation of translational initiation Any process that modulates the frequency, rate or extent of translational initiation. IEA GO:0005852 eukaryotic translation initiation factor 3 complex A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01015014001 443152 447398 GO:0006413 translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any part of a ribosome. IEA GO:0043022 ribosome binding GSVIVG01015014001 443152 447398 GO:0006413 translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. IEA GO:0005852 eukaryotic translation initiation factor 3 complex A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs. IEA Interacting selectively and non-covalently with any part of a ribosome. IEA GO:0043022 ribosome binding GSVIVG01015014001 443152 447398 GO:0006446 regulation of translational initiation Any process that modulates the frequency, rate or extent of translational initiation. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any part of a ribosome. IEA GO:0043022 ribosome binding GSVIVG01015014001 443152 447398 GO:0006446 regulation of translational initiation Any process that modulates the frequency, rate or extent of translational initiation. IEA GO:0005852 eukaryotic translation initiation factor 3 complex A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs. IEA Interacting selectively and non-covalently with any part of a ribosome. IEA GO:0043022 ribosome binding GSVIVG01016314001 5203314 5226671 GSVIVG01011543001 12674906 12697098 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01013408001 646526 652067 GO:0008219 cell death A biological process that results in permanent cessation of all vital functions of a cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01016325001 5080825 5082197 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GSVIVG01014675001 8464491 8466738 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01024153001 722303 732978 GO:0006014 D-ribose metabolic process The chemical reactions and pathways involving D-ribose (ribo-pentose). As beta-D-ribofuranose, D-ribose forms the glycose moiety of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12. IEA Catalysis of the reaction: ATP + D-ribose = ADP + D-ribose 5-phosphate. IEA GO:0004747 ribokinase activity GSVIVG01034189001 14550654 14554703 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01034189001 14550654 14554703 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01010230001 17986243 17994297 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01026923001 19375374 19377785 GSVIVG01035293001 129856 154757 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01035293001 129856 154757 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01035293001 129856 154757 GO:0006436 tryptophanyl-tRNA aminoacylation The process of coupling tryptophan to tryptophanyl-tRNA, catalyzed by tryptophanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01035293001 129856 154757 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01035293001 129856 154757 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01035293001 129856 154757 GO:0006436 tryptophanyl-tRNA aminoacylation The process of coupling tryptophan to tryptophanyl-tRNA, catalyzed by tryptophanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01035293001 129856 154757 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophanyl-tRNA(Trp). IEA GO:0004830 tryptophan-tRNA ligase activity GSVIVG01035293001 129856 154757 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophanyl-tRNA(Trp). IEA GO:0004830 tryptophan-tRNA ligase activity GSVIVG01035293001 129856 154757 GO:0006436 tryptophanyl-tRNA aminoacylation The process of coupling tryptophan to tryptophanyl-tRNA, catalyzed by tryptophanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophanyl-tRNA(Trp). IEA GO:0004830 tryptophan-tRNA ligase activity GSVIVG01035293001 129856 154757 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035293001 129856 154757 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035293001 129856 154757 GO:0006436 tryptophanyl-tRNA aminoacylation The process of coupling tryptophan to tryptophanyl-tRNA, catalyzed by tryptophanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011625001 5806547 5811465 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01033974001 16185457 16185971 GSVIVG01032348001 26536960 26551882 GSVIVG01036330001 3868600 3880169 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01036330001 3868600 3880169 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01011617001 5922276 5931486 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA GSVIVG01011617001 5922276 5931486 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01036382001 4471762 4472085 GSVIVG01018938001 18530894 18534713 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018938001 18530894 18534713 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. IEA GO:0016853 isomerase activity GSVIVG01018938001 18530894 18534713 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01033263001 22044384 22046297 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030567001 6803788 6812111 GSVIVG01038023001 16413689 16414795 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01025324001 2026162 2029978 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01008137001 5482657 5494676 GSVIVG01012124001 1226337 1240986 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a nucleotidyl group to a reactant. IEA GO:0016779 nucleotidyltransferase activity GSVIVG01031827001 4733147 4734032 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01031827001 4733147 4734032 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01000714001 116653 126821 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01000714001 116653 126821 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01000714001 116653 126821 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01000714001 116653 126821 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01026296001 12956304 12969259 GSVIVG01023859001 2923762 2927199 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: an N-acyl-L-amino acid + H2O = a carboxylate + an L-amino acid. IEA GO:0004046 aminoacylase activity GSVIVG01023859001 2923762 2927199 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: an N-acyl-L-amino acid + H2O = a carboxylate + an L-amino acid. IEA GO:0004046 aminoacylase activity GSVIVG01023859001 2923762 2927199 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: an N-acyl-L-amino acid + H2O = a carboxylate + an L-amino acid. IEA GO:0004046 aminoacylase activity GSVIVG01023859001 2923762 2927199 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008237 metallopeptidase activity GSVIVG01023859001 2923762 2927199 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008237 metallopeptidase activity GSVIVG01023859001 2923762 2927199 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008237 metallopeptidase activity GSVIVG01023859001 2923762 2927199 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01023859001 2923762 2927199 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01023859001 2923762 2927199 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01018327001 10988829 10993249 GO:0016068 type I hypersensitivity An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells or basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01018327001 10988829 10993249 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01018327001 10988829 10993249 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01033350001 21302624 21308510 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01036310001 3676813 3683012 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01021223001 2714468 2717867 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004197 cysteine-type endopeptidase activity GSVIVG01021223001 2714468 2717867 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004197 cysteine-type endopeptidase activity GSVIVG01021223001 2714468 2717867 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004197 cysteine-type endopeptidase activity GSVIVG01021223001 2714468 2717867 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004197 cysteine-type endopeptidase activity GSVIVG01021223001 2714468 2717867 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004197 cysteine-type endopeptidase activity GSVIVG01021223001 2714468 2717867 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004197 cysteine-type endopeptidase activity GSVIVG01021223001 2714468 2717867 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004197 cysteine-type endopeptidase activity GSVIVG01021223001 2714468 2717867 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004197 cysteine-type endopeptidase activity GSVIVG01021223001 2714468 2717867 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004197 cysteine-type endopeptidase activity GSVIVG01021223001 2714468 2717867 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. IEA GO:0005179 hormone activity GSVIVG01021223001 2714468 2717867 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. IEA GO:0005179 hormone activity GSVIVG01021223001 2714468 2717867 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. IEA GO:0005179 hormone activity GSVIVG01021223001 2714468 2717867 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. IEA GO:0005179 hormone activity GSVIVG01021223001 2714468 2717867 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. IEA GO:0005179 hormone activity GSVIVG01021223001 2714468 2717867 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. IEA GO:0005179 hormone activity GSVIVG01021223001 2714468 2717867 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. IEA GO:0005179 hormone activity GSVIVG01021223001 2714468 2717867 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. IEA GO:0005179 hormone activity GSVIVG01021223001 2714468 2717867 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. IEA GO:0005179 hormone activity GSVIVG01021223001 2714468 2717867 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01021223001 2714468 2717867 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01021223001 2714468 2717867 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01021223001 2714468 2717867 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01021223001 2714468 2717867 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01021223001 2714468 2717867 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01021223001 2714468 2717867 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01021223001 2714468 2717867 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01021223001 2714468 2717867 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01021223001 2714468 2717867 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01021223001 2714468 2717867 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01021223001 2714468 2717867 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01021223001 2714468 2717867 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01021223001 2714468 2717867 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01021223001 2714468 2717867 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01021223001 2714468 2717867 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01021223001 2714468 2717867 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01021223001 2714468 2717867 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01036002001 7007089 7008322 GSVIVG01031037001 21228318 21236567 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01013132001 7866503 7876163 GSVIVG01035616001 2742866 2747044 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA Catalysis of the reaction: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA. IEA GO:0004045 aminoacyl-tRNA hydrolase activity GSVIVG01009093001 4982015 4983627 GSVIVG01027419001 16893483 16897766 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01027419001 16893483 16897766 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01027419001 16893483 16897766 GO:0007601 visual perception The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01027419001 16893483 16897766 GO:0007601 visual perception The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01027419001 16893483 16897766 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01027419001 16893483 16897766 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01027419001 16893483 16897766 GO:0007601 visual perception The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01027419001 16893483 16897766 GO:0007601 visual perception The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01024982001 5522897 5528592 GSVIVG01008110001 5699276 5706599 GSVIVG01019411001 447132 448304 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019411001 447132 448304 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019411001 447132 448304 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019411001 447132 448304 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019411001 447132 448304 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01019411001 447132 448304 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01019411001 447132 448304 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01019411001 447132 448304 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01013013001 10234831 10235846 GSVIVG01006723001 1253946 1257353 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01006723001 1253946 1257353 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01006723001 1253946 1257353 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01006723001 1253946 1257353 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01016185001 6919165 6921123 GSVIVG01018731001 20327038 20339205 GO:0006464 protein modification process The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01018731001 20327038 20339205 GO:0006464 protein modification process The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. IEA GO:0016881 acid-amino acid ligase activity GSVIVG01001629001 21525047 21527156 GSVIVG01019434001 666668 672560 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019434001 666668 672560 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01019434001 666668 672560 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01027763001 7484034 7487872 GSVIVG01026307001 13311389 13319110 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004185 serine-type carboxypeptidase activity GSVIVG01026307001 13311389 13319110 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01009877001 12013911 12014156 GSVIVG01025554001 14085067 14089386 Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage. IEA GO:0016209 antioxidant activity GSVIVG01025554001 14085067 14089386 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01030673001 13346304 13352403 GSVIVG01013234001 6442238 6449184 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01013234001 6442238 6449184 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01013234001 6442238 6449184 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01013234001 6442238 6449184 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01013234001 6442238 6449184 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01013234001 6442238 6449184 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01013387001 792131 803420 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01013387001 792131 803420 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0010181 FMN binding GSVIVG01013387001 792131 803420 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031817001 4667874 4668867 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000381001 381725 382396 GSVIVG01032997001 24957840 24958770 GSVIVG01011140001 7116834 7124579 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01011140001 7116834 7124579 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019556001 1585586 1594666 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01019556001 1585586 1594666 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01033772001 17969030 17970816 GSVIVG01033954001 16352166 16360573 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01006511001 42541413 42541502 GSVIVG01021453001 5539233 5542323 GSVIVG01003757001 12418370 12436012 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01003757001 12418370 12436012 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01003757001 12418370 12436012 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01003757001 12418370 12436012 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01032022001 23466091 23467704 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032022001 23466091 23467704 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01032022001 23466091 23467704 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01021664001 8921209 8923235 GSVIVG01015215001 1881842 1884737 GSVIVG01000515001 13494305 13495345 GSVIVG01032655001 1785126 1791259 GSVIVG01030042001 9081555 9083654 Catalysis of the reaction: ATP + thymidine = ADP + thymidine 5'-phosphate. IEA GO:0004797 thymidine kinase activity GSVIVG01030042001 9081555 9083654 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003950001 13976382 13980100 GSVIVG01006404001 25656549 25663852 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01012110001 1353272 1355920 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01012110001 1353272 1355920 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01021061001 14282921 14291181 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01021061001 14282921 14291181 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01009800001 11338257 11346084 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01032815001 531636 537386 Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. IEA GO:0016791 phosphatase activity GSVIVG01029319001 16926494 16932969 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01031526001 17589925 17594133 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031526001 17589925 17594133 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031526001 17589925 17594133 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031526001 17589925 17594133 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008333001 3160577 3167175 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01008333001 3160577 3167175 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019149001 16120035 16124634 GSVIVG01022268001 18036491 18041933 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01022268001 18036491 18041933 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01022268001 18036491 18041933 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01022268001 18036491 18041933 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038236001 24537542 24539980 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01038236001 24537542 24539980 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01038236001 24537542 24539980 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01038236001 24537542 24539980 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01038236001 24537542 24539980 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01038236001 24537542 24539980 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01038236001 24537542 24539980 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01038236001 24537542 24539980 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024318001 789473 791233 GSVIVG01033561001 19750528 19752569 GSVIVG01036017001 7263244 7279815 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01020522001 4853379 4869767 GSVIVG01017066001 3924340 3925260 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005875 microtubule associated complex Any multimeric complex connected to a microtubule. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01012889001 6543314 6545800 GSVIVG01025242001 2787445 2788412 GSVIVG01006876001 28781234 28782604 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01006205001 23671167 23671657 GSVIVG01002586001 35320806 35323373 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01002586001 35320806 35323373 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01035976001 6686872 6688595 GSVIVG01013763001 7835562 7837696 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01016674001 279342 290391 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016674001 279342 290391 GO:0046488 phosphatidylinositol metabolic process The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016674001 279342 290391 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016674001 279342 290391 GO:0046488 phosphatidylinositol metabolic process The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016674001 279342 290391 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01016674001 279342 290391 GO:0046488 phosphatidylinositol metabolic process The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01016674001 279342 290391 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA Catalysis of the phosphorylation of phosphatidylinositol phosphate to produce phosphatidylinositol bisphosphate. IEA GO:0016307 phosphatidylinositol phosphate kinase activity GSVIVG01016674001 279342 290391 GO:0046488 phosphatidylinositol metabolic process The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. IEA Catalysis of the phosphorylation of phosphatidylinositol phosphate to produce phosphatidylinositol bisphosphate. IEA GO:0016307 phosphatidylinositol phosphate kinase activity GSVIVG01009990001 13191894 13196265 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01009990001 13191894 13196265 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01009990001 13191894 13196265 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01009990001 13191894 13196265 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01028424001 7426278 7436144 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01028424001 7426278 7436144 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01021274001 3271261 3273334 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01021274001 3271261 3273334 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01021274001 3271261 3273334 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01021274001 3271261 3273334 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01012493001 13887154 13887515 GSVIVG01027753001 7413732 7415180 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01000971001 22388040 22389199 GSVIVG01013487001 1561236 1572680 GSVIVG01008303001 3453989 3455697 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01008513001 1238487 1241306 GSVIVG01008268001 3777808 3798404 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01011128001 1348012 1364108 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01013540001 20411467 20425543 GSVIVG01020606001 3836442 3837086 GSVIVG01004896001 16533561 16534175 GSVIVG01008319001 3284712 3285848 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar. IEA GO:0008375 acetylglucosaminyltransferase activity GSVIVG01035600001 2617385 2618366 GSVIVG01020834001 1387184 1390347 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01036817001 17409920 17427601 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01036817001 17409920 17427601 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01036817001 17409920 17427601 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01036817001 17409920 17427601 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01036817001 17409920 17427601 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01036817001 17409920 17427601 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01036817001 17409920 17427601 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01036817001 17409920 17427601 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01036817001 17409920 17427601 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036817001 17409920 17427601 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036817001 17409920 17427601 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01036817001 17409920 17427601 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01010530001 21504805 21506303 GSVIVG01006039001 23395315 23399645 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01038597001 21608209 21615368 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01038597001 21608209 21615368 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01002213001 33426614 33426769 GSVIVG01018778001 20005136 20011413 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01018778001 20005136 20011413 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01018778001 20005136 20011413 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01018778001 20005136 20011413 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01018778001 20005136 20011413 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018778001 20005136 20011413 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026990001 18769577 18772372 GSVIVG01038047001 16915105 16916114 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. IEA GO:0004364 glutathione transferase activity GSVIVG01038047001 16915105 16916114 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01034757001 9092008 9099567 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01034757001 9092008 9099567 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01034757001 9092008 9099567 GO:0006414 translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01034757001 9092008 9099567 GO:0006414 translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01034757001 9092008 9099567 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01034757001 9092008 9099567 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01034757001 9092008 9099567 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01034757001 9092008 9099567 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01034757001 9092008 9099567 GO:0006414 translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01034757001 9092008 9099567 GO:0006414 translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01034757001 9092008 9099567 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01034757001 9092008 9099567 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027807001 7989420 7993613 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01017538001 10183379 10184240 GSVIVG01032792001 733275 751116 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030130 clathrin coat of trans-Golgi network vesicle A clathrin coat found on a vesicle of the trans-Golgi network. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01032792001 733275 751116 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030132 clathrin coat of coated pit The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01032792001 733275 751116 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030130 clathrin coat of trans-Golgi network vesicle A clathrin coat found on a vesicle of the trans-Golgi network. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01032792001 733275 751116 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030132 clathrin coat of coated pit The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01032792001 733275 751116 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030130 clathrin coat of trans-Golgi network vesicle A clathrin coat found on a vesicle of the trans-Golgi network. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032792001 733275 751116 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030132 clathrin coat of coated pit The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032792001 733275 751116 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030130 clathrin coat of trans-Golgi network vesicle A clathrin coat found on a vesicle of the trans-Golgi network. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032792001 733275 751116 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030132 clathrin coat of coated pit The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032792001 733275 751116 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030130 clathrin coat of trans-Golgi network vesicle A clathrin coat found on a vesicle of the trans-Golgi network. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032792001 733275 751116 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030132 clathrin coat of coated pit The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032792001 733275 751116 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030130 clathrin coat of trans-Golgi network vesicle A clathrin coat found on a vesicle of the trans-Golgi network. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032792001 733275 751116 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030132 clathrin coat of coated pit The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01022211001 17526138 17526478 GSVIVG01032979001 24776768 24787568 GSVIVG01013775001 7707925 7712877 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013775001 7707925 7712877 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01028812001 18494017 18495759 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01038199001 24279936 24288798 GSVIVG01005676001 21140636 21144765 Catalysis of the transfer of the amide nitrogen of glutamine to a variety of substrates. GATases catalyze two separate reactions at two active sites, which are located either on a single polypeptide chain or on different subunits. In the glutaminase reaction, glutamine is hydrolyzed to glutamate and ammonia, which is added to an acceptor substrate in the synthase reaction. IEA GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor GSVIVG01000808001 358994 359834 GSVIVG01021152001 1869067 1872340 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01021152001 1869067 1872340 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01021152001 1869067 1872340 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01021152001 1869067 1872340 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01021382001 4690374 4700689 Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. IEA GO:0016791 phosphatase activity GSVIVG01037384001 14614433 14627074 GO:0006534 cysteine metabolic process The chemical reactions and pathways involving cysteine, 2-amino-3-mercaptopropanoic acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01037384001 14614433 14627074 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01037384001 14614433 14627074 GO:0006534 cysteine metabolic process The chemical reactions and pathways involving cysteine, 2-amino-3-mercaptopropanoic acid. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01037384001 14614433 14627074 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01037384001 14614433 14627074 GO:0006534 cysteine metabolic process The chemical reactions and pathways involving cysteine, 2-amino-3-mercaptopropanoic acid. IEA Catalysis of the reaction: L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine. IEA GO:0031071 cysteine desulfurase activity GSVIVG01037384001 14614433 14627074 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine. IEA GO:0031071 cysteine desulfurase activity GSVIVG01017978001 5255466 5259119 GSVIVG01035269001 11655992 11658759 GSVIVG01029753001 14184316 14190383 GO:0005986 sucrose biosynthetic process The chemical reactions and pathways resulting in the formation of sucrose, the disaccharide fructofuranosyl-glucopyranoside. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01029753001 14184316 14190383 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01029753001 14184316 14190383 GO:0005986 sucrose biosynthetic process The chemical reactions and pathways resulting in the formation of sucrose, the disaccharide fructofuranosyl-glucopyranoside. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029753001 14184316 14190383 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029753001 14184316 14190383 GO:0005986 sucrose biosynthetic process The chemical reactions and pathways resulting in the formation of sucrose, the disaccharide fructofuranosyl-glucopyranoside. IEA Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. IEA GO:0016791 phosphatase activity GSVIVG01029753001 14184316 14190383 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. IEA GO:0016791 phosphatase activity GSVIVG01029753001 14184316 14190383 GO:0005986 sucrose biosynthetic process The chemical reactions and pathways resulting in the formation of sucrose, the disaccharide fructofuranosyl-glucopyranoside. IEA Catalysis of the reaction: sucrose 6F-phosphate + H2O = sucrose + phosphate. IEA GO:0050307 sucrose-phosphatase activity GSVIVG01029753001 14184316 14190383 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: sucrose 6F-phosphate + H2O = sucrose + phosphate. IEA GO:0050307 sucrose-phosphatase activity GSVIVG01027874001 8874203 8882011 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01027874001 8874203 8882011 GO:0009439 cyanate metabolic process The chemical reactions and pathways involving cyanate, NCO-, the anion of cyanic acid. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01027874001 8874203 8882011 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: cyanate (NCO-) + H2O = carbamate (H2N-CO-O-). IEA GO:0008824 cyanate hydratase activity GSVIVG01027874001 8874203 8882011 GO:0009439 cyanate metabolic process The chemical reactions and pathways involving cyanate, NCO-, the anion of cyanic acid. IEA Catalysis of the reaction: cyanate (NCO-) + H2O = carbamate (H2N-CO-O-). IEA GO:0008824 cyanate hydratase activity GSVIVG01027874001 8874203 8882011 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. IEA GO:0016836 hydro-lyase activity GSVIVG01027874001 8874203 8882011 GO:0009439 cyanate metabolic process The chemical reactions and pathways involving cyanate, NCO-, the anion of cyanic acid. IEA Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. IEA GO:0016836 hydro-lyase activity GSVIVG01001127001 22844922 22845044 GSVIVG01000411001 7633242 7633989 GSVIVG01031072001 21835608 21837015 GSVIVG01006457001 26113347 26128743 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01006457001 26113347 26128743 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01006457001 26113347 26128743 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01006457001 26113347 26128743 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01006457001 26113347 26128743 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01006457001 26113347 26128743 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01006457001 26113347 26128743 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01006457001 26113347 26128743 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024289001 574389 577025 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01024289001 574389 577025 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01024289001 574389 577025 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01024289001 574389 577025 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01038533001 11175987 11177138 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01038533001 11175987 11177138 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01038533001 11175987 11177138 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01010272001 18668411 18669651 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01010272001 18668411 18669651 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01010272001 18668411 18669651 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01010272001 18668411 18669651 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01009376001 7880354 7881001 Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01009376001 7880354 7881001 Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01009376001 7880354 7881001 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01015639001 14578246 14585659 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01015639001 14578246 14585659 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01023134001 22228663 22230523 GSVIVG01010231001 18001134 18011125 GO:0006974 response to DNA damage stimulus A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01010231001 18001134 18011125 GO:0007049 cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01010231001 18001134 18011125 GO:0048478 replication fork protection Any process that prevents the collapse of stalled replication forks. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01010231001 18001134 18011125 GO:0006974 response to DNA damage stimulus A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01010231001 18001134 18011125 GO:0007049 cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01010231001 18001134 18011125 GO:0048478 replication fork protection Any process that prevents the collapse of stalled replication forks. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01013801001 7435827 7440374 GSVIVG01022208001 17473258 17475171 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01020837001 1264842 1267013 GO:0009072 aromatic amino acid family metabolic process The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). IEA Catalysis of the reaction: 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2. IEA GO:0003868 4-hydroxyphenylpyruvate dioxygenase activity GSVIVG01024482001 3136309 3141258 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0016592 mediator complex A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. IEA Functions to mediate the interaction of transcriptional activators with the RNA polymerase II-general RNA polymerase II transcription factor complex. IEA GO:0016455 RNA polymerase II transcription mediator activity GSVIVG01035506001 1870706 1873972 GSVIVG01031211001 1151351 1155250 GSVIVG01012650001 351096 354607 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012650001 351096 354607 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01012650001 351096 354607 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01036435001 5118198 5121464 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01036435001 5118198 5121464 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01036435001 5118198 5121464 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01036435001 5118198 5121464 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01036435001 5118198 5121464 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036435001 5118198 5121464 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031964001 5768049 5770485 GSVIVG01020300001 21714926 21715350 GSVIVG01032198001 21612015 21617231 GSVIVG01037246001 16933003 16934031 GSVIVG01034589001 14834280 14836783 GSVIVG01034114001 15068912 15073514 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01034114001 15068912 15073514 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01034114001 15068912 15073514 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01034114001 15068912 15073514 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01034114001 15068912 15073514 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01034114001 15068912 15073514 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01034114001 15068912 15073514 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01034114001 15068912 15073514 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01034114001 15068912 15073514 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01034114001 15068912 15073514 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01034114001 15068912 15073514 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01034114001 15068912 15073514 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01034114001 15068912 15073514 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01034114001 15068912 15073514 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01034114001 15068912 15073514 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01012620001 119119 122153 GSVIVG01037623001 6322180 6323029 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01037623001 6322180 6323029 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01037623001 6322180 6323029 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01037623001 6322180 6323029 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01037165001 28413583 28417917 GO:0006006 glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. IEA Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+. IEA GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity GSVIVG01037165001 28413583 28417917 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+. IEA GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity GSVIVG01037165001 28413583 28417917 GO:0006006 glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01037165001 28413583 28417917 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01008537001 1017857 1022127 GSVIVG01023393001 12730208 12834845 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01023393001 12730208 12834845 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01023393001 12730208 12834845 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01023393001 12730208 12834845 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023393001 12730208 12834845 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01031413001 18876808 18913577 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031413001 18876808 18913577 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031413001 18876808 18913577 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031413001 18876808 18913577 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031413001 18876808 18913577 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031413001 18876808 18913577 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031413001 18876808 18913577 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031413001 18876808 18913577 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031413001 18876808 18913577 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031413001 18876808 18913577 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031413001 18876808 18913577 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031413001 18876808 18913577 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031413001 18876808 18913577 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031413001 18876808 18913577 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031413001 18876808 18913577 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031413001 18876808 18913577 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031413001 18876808 18913577 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031413001 18876808 18913577 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031413001 18876808 18913577 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01031413001 18876808 18913577 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01031413001 18876808 18913577 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01031413001 18876808 18913577 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01031413001 18876808 18913577 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01031413001 18876808 18913577 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01031413001 18876808 18913577 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01031413001 18876808 18913577 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01031413001 18876808 18913577 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01025388001 1165640 1166332 GSVIVG01027211001 18214082 18234908 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01005040001 17602627 17620677 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01013913001 6676172 6677138 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01013913001 6676172 6677138 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01021289001 3527408 3540220 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01021289001 3527408 3540220 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01021289001 3527408 3540220 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01021289001 3527408 3540220 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01021289001 3527408 3540220 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016329001 4999327 4999957 GSVIVG01028840001 18215066 18216904 GSVIVG01014723001 8994330 8994573 GSVIVG01031907001 5292443 5302186 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01031907001 5292443 5302186 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01031907001 5292443 5302186 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01031907001 5292443 5302186 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031907001 5292443 5302186 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031907001 5292443 5302186 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031907001 5292443 5302186 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA A ligand-dependent receptor found in the nucleus of the cell. IEA GO:0004879 ligand-dependent nuclear receptor activity GSVIVG01031907001 5292443 5302186 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA A ligand-dependent receptor found in the nucleus of the cell. IEA GO:0004879 ligand-dependent nuclear receptor activity GSVIVG01031907001 5292443 5302186 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA A ligand-dependent receptor found in the nucleus of the cell. IEA GO:0004879 ligand-dependent nuclear receptor activity GSVIVG01031907001 5292443 5302186 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031907001 5292443 5302186 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031907001 5292443 5302186 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031907001 5292443 5302186 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01031907001 5292443 5302186 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01031907001 5292443 5302186 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01021739001 10359501 10361096 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021739001 10359501 10361096 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021739001 10359501 10361096 Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01035483001 1658855 1667251 GO:0006471 protein amino acid ADP-ribosylation The transfer, from NAD, of ADP-ribose to protein amino acids. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01035483001 1658855 1667251 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01035483001 1658855 1667251 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01035483001 1658855 1667251 GO:0006471 protein amino acid ADP-ribosylation The transfer, from NAD, of ADP-ribose to protein amino acids. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01035483001 1658855 1667251 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01035483001 1658855 1667251 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01035483001 1658855 1667251 GO:0006471 protein amino acid ADP-ribosylation The transfer, from NAD, of ADP-ribose to protein amino acids. IEA Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate. IEA GO:0019001 guanyl nucleotide binding GSVIVG01035483001 1658855 1667251 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate. IEA GO:0019001 guanyl nucleotide binding GSVIVG01035483001 1658855 1667251 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate. IEA GO:0019001 guanyl nucleotide binding GSVIVG01021082001 13901214 13919034 GSVIVG01017925001 4748334 4764341 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017925001 4748334 4764341 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01028245001 4904415 4907495 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01003979001 26437662 26444075 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0008076 voltage-gated potassium channel complex A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01038744001 348490 351372 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038744001 348490 351372 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038744001 348490 351372 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01038744001 348490 351372 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01038744001 348490 351372 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01038744001 348490 351372 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01006300001 24741418 24742545 GSVIVG01011902001 3143018 3144306 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01011902001 3143018 3144306 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01035093001 1424963 1428963 GSVIVG01023189001 21364945 21373771 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01011181001 7855266 7860998 GSVIVG01026227001 14421703 14445101 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026227001 14421703 14445101 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: ADP + phosphate + acetyl-CoA + oxaloacetate = ATP + citrate + CoA. IEA GO:0003878 ATP citrate synthase activity GSVIVG01026227001 14421703 14445101 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: ATP + succinate + CoA = ADP + succinyl-CoA + phosphate. IEA GO:0004775 succinate-CoA ligase (ADP-forming) activity GSVIVG01026227001 14421703 14445101 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024977001 5564299 5566010 GSVIVG01020570001 4214507 4220243 GO:0001682 tRNA 5'-leader removal Generation of the mature 5'-end of the tRNA, usually via an endonucleolytic cleavage by RNase P. IEA Catalysis of the endonucleolytic cleavage of RNA, removing 5' extra nucleotides from tRNA precursor. IEA GO:0004526 ribonuclease P activity GSVIVG01020570001 4214507 4220243 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Catalysis of the endonucleolytic cleavage of RNA, removing 5' extra nucleotides from tRNA precursor. IEA GO:0004526 ribonuclease P activity GSVIVG01019818001 3590882 3593551 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01019818001 3590882 3593551 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01019818001 3590882 3593551 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01019818001 3590882 3593551 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01032556001 28341669 28343247 GSVIVG01027009001 18592297 18604142 GSVIVG01033957001 16323253 16328346 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = D-myo-inositol 1,4,5-trisphosphate + diacylglycerol. IEA GO:0004435 phosphoinositide phospholipase C activity GSVIVG01033957001 16323253 16328346 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = D-myo-inositol 1,4,5-trisphosphate + diacylglycerol. IEA GO:0004435 phosphoinositide phospholipase C activity GSVIVG01033957001 16323253 16328346 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate. IEA GO:0004629 phospholipase C activity GSVIVG01033957001 16323253 16328346 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate. IEA GO:0004629 phospholipase C activity GSVIVG01033957001 16323253 16328346 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01033957001 16323253 16328346 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01033957001 16323253 16328346 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. IEA GO:0008081 phosphoric diester hydrolase activity GSVIVG01033957001 16323253 16328346 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. IEA GO:0008081 phosphoric diester hydrolase activity GSVIVG01037415001 14154983 14172657 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. IEA GO:0008080 N-acetyltransferase activity GSVIVG01032023001 23453483 23466090 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032023001 23453483 23466090 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01032023001 23453483 23466090 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01016274001 5613873 5614569 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01016274001 5613873 5614569 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01016274001 5613873 5614569 GO:0008283 cell proliferation The multiplication or reproduction of cells, resulting in the expansion of a cell population. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01016274001 5613873 5614569 GO:0008283 cell proliferation The multiplication or reproduction of cells, resulting in the expansion of a cell population. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01016274001 5613873 5614569 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Functions to control the survival, growth, differentiation and effector function of tissues and cells. IEA GO:0005125 cytokine activity GSVIVG01016274001 5613873 5614569 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Functions to control the survival, growth, differentiation and effector function of tissues and cells. IEA GO:0005125 cytokine activity GSVIVG01016274001 5613873 5614569 GO:0008283 cell proliferation The multiplication or reproduction of cells, resulting in the expansion of a cell population. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Functions to control the survival, growth, differentiation and effector function of tissues and cells. IEA GO:0005125 cytokine activity GSVIVG01016274001 5613873 5614569 GO:0008283 cell proliferation The multiplication or reproduction of cells, resulting in the expansion of a cell population. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Functions to control the survival, growth, differentiation and effector function of tissues and cells. IEA GO:0005125 cytokine activity GSVIVG01004774001 15963872 15979278 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01004774001 15963872 15979278 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01006138001 42051072 42051843 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA Interacting selectively and non-covalently with nickel (Ni) ions. IEA GO:0016151 nickel ion binding GSVIVG01037177001 28294818 28296663 GSVIVG01008716001 1434078 1436613 GO:0001522 pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01008716001 1434078 1436613 GO:0009451 RNA modification The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01008716001 1434078 1436613 GO:0001522 pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs. IEA Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. IEA GO:0009982 pseudouridine synthase activity GSVIVG01008716001 1434078 1436613 GO:0009451 RNA modification The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. IEA Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. IEA GO:0009982 pseudouridine synthase activity GSVIVG01005150001 18637445 18638235 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01005150001 18637445 18638235 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01024638001 8139938 8142367 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0005835 fatty acid synthase complex A multienzyme complex that catalyses the synthesis of fatty acids from acetyl CoA. IEA Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+. IEA GO:0004312 fatty acid synthase activity GSVIVG01024638001 8139938 8142367 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005835 fatty acid synthase complex A multienzyme complex that catalyses the synthesis of fatty acids from acetyl CoA. IEA Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+. IEA GO:0004312 fatty acid synthase activity GSVIVG01024638001 8139938 8142367 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005835 fatty acid synthase complex A multienzyme complex that catalyses the synthesis of fatty acids from acetyl CoA. IEA Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+. IEA GO:0004312 fatty acid synthase activity GSVIVG01024638001 8139938 8142367 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0005835 fatty acid synthase complex A multienzyme complex that catalyses the synthesis of fatty acids from acetyl CoA. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01024638001 8139938 8142367 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005835 fatty acid synthase complex A multienzyme complex that catalyses the synthesis of fatty acids from acetyl CoA. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01024638001 8139938 8142367 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005835 fatty acid synthase complex A multienzyme complex that catalyses the synthesis of fatty acids from acetyl CoA. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01028230001 4796672 4800138 GSVIVG01021510001 6427996 6428758 GSVIVG01032116001 22524698 22539580 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01011202001 9396344 9398955 GSVIVG01002125001 33087312 33093437 GSVIVG01020847001 1117908 1120962 GSVIVG01014181001 1293571 1301426 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01014181001 1293571 1301426 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01014181001 1293571 1301426 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01014181001 1293571 1301426 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01014181001 1293571 1301426 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01014181001 1293571 1301426 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014181001 1293571 1301426 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014181001 1293571 1301426 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014181001 1293571 1301426 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014181001 1293571 1301426 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014181001 1293571 1301426 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01014181001 1293571 1301426 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01014181001 1293571 1301426 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01014181001 1293571 1301426 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01014181001 1293571 1301426 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01025852001 11212722 11217326 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017463001 8823274 8830283 GSVIVG01022723001 15587961 15590452 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. IEA GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GSVIVG01009900001 12257485 12261233 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01009900001 12257485 12261233 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01009900001 12257485 12261233 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01009900001 12257485 12261233 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01021035001 14955237 14956390 GSVIVG01023861001 2918806 2921293 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01030005001 8871855 8889395 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030005001 8871855 8889395 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030005001 8871855 8889395 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01030005001 8871855 8889395 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01015195001 1712909 1719910 GO:0006413 translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. IEA Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. IEA GO:0003743 translation initiation factor activity GSVIVG01009478001 8713430 8718488 GSVIVG01016472001 3574680 3578959 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016472001 3574680 3578959 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01016472001 3574680 3578959 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01029505001 22216869 22217448 GSVIVG01026258001 15025969 15030834 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026258001 15025969 15030834 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01037873001 6859781 6860409 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA GSVIVG01036905001 17886802 17908532 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01004717001 15472765 15481554 GSVIVG01008694001 1252317 1257960 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01004073001 14553040 14557307 GSVIVG01012215001 501310 504875 GSVIVG01012050001 1785520 1791297 GSVIVG01031138001 1813726 1820052 GSVIVG01014148001 831197 831595 GSVIVG01024456001 2800685 2803300 GSVIVG01036161001 19950629 19952562 GSVIVG01008386001 2589883 2593611 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01008386001 2589883 2593611 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01008386001 2589883 2593611 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008386001 2589883 2593611 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022160001 17136824 17138047 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01022160001 17136824 17138047 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end. IEA GO:0004527 exonuclease activity GSVIVG01006468001 26223616 26224341 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01035050001 1178875 1182753 Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01010894001 16161576 16188558 GSVIVG01013482001 1538368 1538649 GSVIVG01013226001 6548155 6549076 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01008817001 2418886 2421454 GSVIVG01022229001 17686867 17692412 Catalysis of the reaction: ATP + shikimate = ADP + shikimate 3-phosphate. IEA GO:0004765 shikimate kinase activity GSVIVG01022229001 17686867 17692412 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022229001 17686867 17692412 Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01037391001 14492104 14548745 GSVIVG01034864001 23026811 23031394 GSVIVG01037390001 14549720 14553161 GSVIVG01029076001 11954399 11969257 GSVIVG01008522001 1129228 1136881 GSVIVG01038551001 21934460 21938446 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01038551001 21934460 21938446 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01038551001 21934460 21938446 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01038551001 21934460 21938446 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01038551001 21934460 21938446 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01038551001 21934460 21938446 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01038551001 21934460 21938446 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01038551001 21934460 21938446 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01038551001 21934460 21938446 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01036714001 23412509 23437714 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GSVIVG01006339001 308600 320133 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01006339001 308600 320133 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01006339001 308600 320133 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01006339001 308600 320133 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01006339001 308600 320133 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01006339001 308600 320133 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006339001 308600 320133 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01035431001 1228852 1229941 GSVIVG01015233001 1995214 2007865 GSVIVG01018156001 13798799 13803908 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01018156001 13798799 13803908 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01018156001 13798799 13803908 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01018156001 13798799 13803908 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01018156001 13798799 13803908 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01018156001 13798799 13803908 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01018156001 13798799 13803908 GO:0006974 response to DNA damage stimulus A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01018156001 13798799 13803908 GO:0006974 response to DNA damage stimulus A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01018156001 13798799 13803908 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01018156001 13798799 13803908 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01018156001 13798799 13803908 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01018156001 13798799 13803908 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01018156001 13798799 13803908 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01018156001 13798799 13803908 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01018156001 13798799 13803908 GO:0006974 response to DNA damage stimulus A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01018156001 13798799 13803908 GO:0006974 response to DNA damage stimulus A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01018156001 13798799 13803908 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01018156001 13798799 13803908 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01018156001 13798799 13803908 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01018156001 13798799 13803908 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01018156001 13798799 13803908 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01018156001 13798799 13803908 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01018156001 13798799 13803908 GO:0006974 response to DNA damage stimulus A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01018156001 13798799 13803908 GO:0006974 response to DNA damage stimulus A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01037779001 7784053 7785596 GSVIVG01031699001 20325549 20328541 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01031699001 20325549 20328541 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01031699001 20325549 20328541 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01031699001 20325549 20328541 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01031699001 20325549 20328541 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01031699001 20325549 20328541 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01031699001 20325549 20328541 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with neuropeptide Y to initiate a change in cell activity. IEA GO:0004983 neuropeptide Y receptor activity GSVIVG01031699001 20325549 20328541 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with neuropeptide Y to initiate a change in cell activity. IEA GO:0004983 neuropeptide Y receptor activity GSVIVG01031699001 20325549 20328541 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031699001 20325549 20328541 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031699001 20325549 20328541 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031699001 20325549 20328541 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029017001 10769895 10770678 GSVIVG01003157001 6124465 6126180 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01011239001 9965143 9967390 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01024057001 1449296 1450092 Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01033371001 21138602 21144817 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033371001 21138602 21144817 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01008040001 6396463 6408689 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01008040001 6396463 6408689 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008040001 6396463 6408689 Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01008040001 6396463 6408689 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01010925001 15609014 15609611 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01010925001 15609014 15609611 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01021464001 5698703 5703418 GSVIVG01014190001 1351602 1354537 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01003415001 14787888 14790698 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01003415001 14787888 14790698 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01003415001 14787888 14790698 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01003415001 14787888 14790698 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01003415001 14787888 14790698 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01003415001 14787888 14790698 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01003415001 14787888 14790698 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01003415001 14787888 14790698 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01003415001 14787888 14790698 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01003415001 14787888 14790698 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01003415001 14787888 14790698 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01003415001 14787888 14790698 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01003415001 14787888 14790698 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01003415001 14787888 14790698 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01003415001 14787888 14790698 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01003415001 14787888 14790698 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01003415001 14787888 14790698 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01003415001 14787888 14790698 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01003415001 14787888 14790698 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01003415001 14787888 14790698 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01008048001 6285646 6289773 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: cysteamine + O2 = hypotaurine. IEA GO:0047800 cysteamine dioxygenase activity GSVIVG01036526001 23069612 23070629 GSVIVG01033411001 20899616 20905490 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GSVIVG01025316001 2106884 2107695 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01001803001 25940027 25951336 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020759001 2308766 2308903 GSVIVG01010499001 21096155 21107668 GSVIVG01018182001 13472008 13474750 GSVIVG01021298001 3662124 3682329 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01024973001 5587804 5589454 GSVIVG01003695001 12283006 12289052 GSVIVG01009282001 6935594 6943998 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01001109001 22688382 22689371 GSVIVG01003501001 10787479 10793785 GSVIVG01034337001 17887296 17890934 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01034337001 17887296 17890934 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01034337001 17887296 17890934 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01034337001 17887296 17890934 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01019182001 3877587 3883781 Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01019182001 3877587 3883781 Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01019182001 3877587 3883781 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01019182001 3877587 3883781 Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01022381001 19390510 19413577 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01022381001 19390510 19413577 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01013788001 7572938 7577645 GSVIVG01006485001 26438067 26439553 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01033231001 22355168 22372711 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01033231001 22355168 22372711 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01033231001 22355168 22372711 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01033231001 22355168 22372711 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008179001 4964452 4975759 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01008179001 4964452 4975759 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01008179001 4964452 4975759 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01008179001 4964452 4975759 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01008179001 4964452 4975759 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01008179001 4964452 4975759 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01023283001 20149670 20152476 GSVIVG01017923001 4733971 4739497 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01017923001 4733971 4739497 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01010950001 2721265 2725909 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of potassium ions (K+) from one side of a membrane to the other. IEA GO:0015079 potassium ion transmembrane transporter activity GSVIVG01008050001 6265859 6279294 GO:0006198 cAMP catabolic process The chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). IEA Catalysis of the reaction: adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate. IEA GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity GSVIVG01008050001 6265859 6279294 GO:0006198 cAMP catabolic process The chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01017311001 6631424 6632689 GSVIVG01030293001 9346913 9351311 GO:0006826 iron ion transport The directed movement of iron (Fe) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01030293001 9346913 9351311 GO:0006879 cellular iron ion homeostasis Any process involved in the maintenance of an internal steady-state of iron ions at the level of a cell. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01030293001 9346913 9351311 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01030293001 9346913 9351311 GO:0006826 iron ion transport The directed movement of iron (Fe) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with ferric iron, Fe(III). IEA GO:0008199 ferric iron binding GSVIVG01030293001 9346913 9351311 GO:0006879 cellular iron ion homeostasis Any process involved in the maintenance of an internal steady-state of iron ions at the level of a cell. IEA Interacting selectively and non-covalently with ferric iron, Fe(III). IEA GO:0008199 ferric iron binding GSVIVG01030293001 9346913 9351311 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with ferric iron, Fe(III). IEA GO:0008199 ferric iron binding GSVIVG01030293001 9346913 9351311 GO:0006826 iron ion transport The directed movement of iron (Fe) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01030293001 9346913 9351311 GO:0006879 cellular iron ion homeostasis Any process involved in the maintenance of an internal steady-state of iron ions at the level of a cell. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01030293001 9346913 9351311 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01030293001 9346913 9351311 GO:0006826 iron ion transport The directed movement of iron (Fe) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01030293001 9346913 9351311 GO:0006879 cellular iron ion homeostasis Any process involved in the maintenance of an internal steady-state of iron ions at the level of a cell. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01030293001 9346913 9351311 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01003540001 215144 216544 GSVIVG01015084001 923722 924660 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. IEA GO:0008080 N-acetyltransferase activity GSVIVG01033842001 17302334 17306498 GO:0016226 iron-sulfur cluster assembly The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01033842001 17302334 17306498 GO:0016226 iron-sulfur cluster assembly The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01035625001 2781798 2785626 GSVIVG01023596001 7763440 7778002 GSVIVG01024432001 2505835 2506467 GSVIVG01038522001 10961390 10963812 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01016655001 157669 171512 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0000502 proteasome complex A large multisubunit complex which catalyzes protein degradation. This complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016655001 157669 171512 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016655001 157669 171512 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0000502 proteasome complex A large multisubunit complex which catalyzes protein degradation. This complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016655001 157669 171512 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016655001 157669 171512 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0000502 proteasome complex A large multisubunit complex which catalyzes protein degradation. This complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01016655001 157669 171512 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01016655001 157669 171512 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0000502 proteasome complex A large multisubunit complex which catalyzes protein degradation. This complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01016655001 157669 171512 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01017823001 3793982 3795853 GSVIVG01027738001 7335914 7341237 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01004303001 38003425 38006481 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01004303001 38003425 38006481 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01004303001 38003425 38006481 GO:0016068 type I hypersensitivity An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells or basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01004303001 38003425 38006481 GO:0016068 type I hypersensitivity An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells or basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01004303001 38003425 38006481 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01004303001 38003425 38006481 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01004303001 38003425 38006481 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01004303001 38003425 38006481 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01004303001 38003425 38006481 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01004303001 38003425 38006481 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01004303001 38003425 38006481 GO:0016068 type I hypersensitivity An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells or basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01004303001 38003425 38006481 GO:0016068 type I hypersensitivity An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells or basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01004303001 38003425 38006481 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01004303001 38003425 38006481 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01004303001 38003425 38006481 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01004303001 38003425 38006481 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01020259001 22155045 22157218 GSVIVG01024571001 8706804 8778397 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024571001 8706804 8778397 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01024571001 8706804 8778397 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01024571001 8706804 8778397 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01014485001 4330088 4333933 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014485001 4330088 4333933 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014485001 4330088 4333933 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014485001 4330088 4333933 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014485001 4330088 4333933 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014485001 4330088 4333933 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014485001 4330088 4333933 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014485001 4330088 4333933 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014485001 4330088 4333933 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01014485001 4330088 4333933 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01003105001 7267376 7273869 GSVIVG01010355001 19746049 19748206 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01010355001 19746049 19748206 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01010524001 21434900 21451879 GSVIVG01014631001 7967803 7976826 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01014631001 7967803 7976826 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01014631001 7967803 7976826 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014631001 7967803 7976826 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014631001 7967803 7976826 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01014631001 7967803 7976826 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01014631001 7967803 7976826 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01014631001 7967803 7976826 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01014631001 7967803 7976826 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01014631001 7967803 7976826 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01014800001 9955476 9955631 GSVIVG01032213001 21463144 21466424 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with a mating-type factor pheromone to initiate a change in cell activity. IEA GO:0004932 mating-type factor pheromone receptor activity GSVIVG01023351001 19416868 19423786 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01035669001 3168622 3173487 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01015612001 14065349 14066533 GSVIVG01025592001 13782183 13787555 GSVIVG01029430001 23002376 23003202 GSVIVG01007698001 10277074 10279848 GSVIVG01002965001 37475229 37475991 GSVIVG01018921001 18625064 18629091 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035343001 641165 646899 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004197 cysteine-type endopeptidase activity GSVIVG01031368001 19478954 19533756 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). IEA GO:0003755 peptidyl-prolyl cis-trans isomerase activity GSVIVG01031368001 19478954 19533756 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. IEA GO:0016853 isomerase activity GSVIVG01001224001 1546107 1548377 GSVIVG01027259001 17530264 17531028 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01027259001 17530264 17531028 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N2-methylguanine. IEA GO:0004809 tRNA (guanine-N2-)-methyltransferase activity GSVIVG01036619001 19281964 19282294 GSVIVG01012848001 6077774 6084417 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GSVIVG01036054001 21324025 21328615 GSVIVG01028869001 17958291 17958581 GSVIVG01006151001 42188620 42189204 GSVIVG01028203001 4589049 4604696 GSVIVG01019427001 596475 597740 GSVIVG01026505001 22475452 22477877 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026505001 22475452 22477877 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026505001 22475452 22477877 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026505001 22475452 22477877 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026505001 22475452 22477877 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01026505001 22475452 22477877 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01026505001 22475452 22477877 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01026505001 22475452 22477877 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01026505001 22475452 22477877 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01026505001 22475452 22477877 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01011879001 3338925 3340709 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA GSVIVG01028489001 8306041 8317690 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017076001 4006321 4014559 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01017076001 4006321 4014559 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01017076001 4006321 4014559 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01017076001 4006321 4014559 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01006487001 26458405 26459995 GSVIVG01011528001 13051404 13055977 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01011528001 13051404 13055977 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01021454001 5557431 5558746 GSVIVG01019643001 2150787 2160118 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01019643001 2150787 2160118 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01019643001 2150787 2160118 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01019643001 2150787 2160118 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01005416001 40128565 40129373 GSVIVG01025394001 1125322 1126160 GSVIVG01008347001 3063849 3066558 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01036303001 3570527 3572325 GSVIVG01016533001 3045824 3048701 GSVIVG01011117001 1442505 1450308 GSVIVG01010299001 19198278 19200334 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01010299001 19198278 19200334 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01018725001 20382440 20383630 GSVIVG01022403001 19731440 19732022 GO:0009853 photorespiration A light-dependent catabolic process occurring concomitantly with photosynthesis in plants (especially C3 plants) whereby dioxygen (O2) is consumed and carbon dioxide (CO2) is evolved. The substrate is glycolate formed in large quantities in chloroplasts from 2-phosphoglycolate generated from ribulose 1,5-bisphosphate by the action of ribulose-bisphosphate carboxylase; the glycolate enters the peroxisomes where it is converted by glycolate oxidase to glyoxylate which undergoes transamination to glycine. This then passes into the mitochondria where it is decarboxylated forming one molecule of serine for every two molecules of glycine. This pathway also exists in photosynthetic bacteria. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01022403001 19731440 19732022 GO:0009853 photorespiration A light-dependent catabolic process occurring concomitantly with photosynthesis in plants (especially C3 plants) whereby dioxygen (O2) is consumed and carbon dioxide (CO2) is evolved. The substrate is glycolate formed in large quantities in chloroplasts from 2-phosphoglycolate generated from ribulose 1,5-bisphosphate by the action of ribulose-bisphosphate carboxylase; the glycolate enters the peroxisomes where it is converted by glycolate oxidase to glyoxylate which undergoes transamination to glycine. This then passes into the mitochondria where it is decarboxylated forming one molecule of serine for every two molecules of glycine. This pathway also exists in photosynthetic bacteria. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01022403001 19731440 19732022 GO:0009853 photorespiration A light-dependent catabolic process occurring concomitantly with photosynthesis in plants (especially C3 plants) whereby dioxygen (O2) is consumed and carbon dioxide (CO2) is evolved. The substrate is glycolate formed in large quantities in chloroplasts from 2-phosphoglycolate generated from ribulose 1,5-bisphosphate by the action of ribulose-bisphosphate carboxylase; the glycolate enters the peroxisomes where it is converted by glycolate oxidase to glyoxylate which undergoes transamination to glycine. This then passes into the mitochondria where it is decarboxylated forming one molecule of serine for every two molecules of glycine. This pathway also exists in photosynthetic bacteria. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01022403001 19731440 19732022 GO:0015977 carbon fixation A metabolic process in which carbon (usually derived from carbon dioxide) is incorporated into organic compounds (usually carbohydrates). IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01022403001 19731440 19732022 GO:0015977 carbon fixation A metabolic process in which carbon (usually derived from carbon dioxide) is incorporated into organic compounds (usually carbohydrates). IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01022403001 19731440 19732022 GO:0015977 carbon fixation A metabolic process in which carbon (usually derived from carbon dioxide) is incorporated into organic compounds (usually carbohydrates). IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01022403001 19731440 19732022 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01022403001 19731440 19732022 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01022403001 19731440 19732022 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01022403001 19731440 19732022 GO:0019253 reductive pentose-phosphate cycle The fixation of carbon dioxide (CO2) as glucose in the chloroplasts of C3 plants; uses ATP and NADPH formed in the light reactions of photosynthesis; carbon dioxide reacts with ribulose 1,5-bisphosphate (catalyzed by the function of ribulose-bisphosphate carboxylase) to yield two molecules of 3-phosphoglycerate; these are then phosphorylated by ATP to 1,3-bisphosphateglyceraldehyde which, in turn, is then reduced by NADPH to glyceraldehyde 3-phosphate. The glyceraldehyde 3-phosphate is converted to fructose 5-phosphate and ribulose 5-phosphate by aldolase and other enzymes; the ribulose 5-phosphate is phosphorylated by ATP to ribulose 1,5-bisphosphate. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01022403001 19731440 19732022 GO:0019253 reductive pentose-phosphate cycle The fixation of carbon dioxide (CO2) as glucose in the chloroplasts of C3 plants; uses ATP and NADPH formed in the light reactions of photosynthesis; carbon dioxide reacts with ribulose 1,5-bisphosphate (catalyzed by the function of ribulose-bisphosphate carboxylase) to yield two molecules of 3-phosphoglycerate; these are then phosphorylated by ATP to 1,3-bisphosphateglyceraldehyde which, in turn, is then reduced by NADPH to glyceraldehyde 3-phosphate. The glyceraldehyde 3-phosphate is converted to fructose 5-phosphate and ribulose 5-phosphate by aldolase and other enzymes; the ribulose 5-phosphate is phosphorylated by ATP to ribulose 1,5-bisphosphate. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01022403001 19731440 19732022 GO:0019253 reductive pentose-phosphate cycle The fixation of carbon dioxide (CO2) as glucose in the chloroplasts of C3 plants; uses ATP and NADPH formed in the light reactions of photosynthesis; carbon dioxide reacts with ribulose 1,5-bisphosphate (catalyzed by the function of ribulose-bisphosphate carboxylase) to yield two molecules of 3-phosphoglycerate; these are then phosphorylated by ATP to 1,3-bisphosphateglyceraldehyde which, in turn, is then reduced by NADPH to glyceraldehyde 3-phosphate. The glyceraldehyde 3-phosphate is converted to fructose 5-phosphate and ribulose 5-phosphate by aldolase and other enzymes; the ribulose 5-phosphate is phosphorylated by ATP to ribulose 1,5-bisphosphate. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01022403001 19731440 19732022 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01022403001 19731440 19732022 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01022403001 19731440 19732022 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01022403001 19731440 19732022 GO:0009853 photorespiration A light-dependent catabolic process occurring concomitantly with photosynthesis in plants (especially C3 plants) whereby dioxygen (O2) is consumed and carbon dioxide (CO2) is evolved. The substrate is glycolate formed in large quantities in chloroplasts from 2-phosphoglycolate generated from ribulose 1,5-bisphosphate by the action of ribulose-bisphosphate carboxylase; the glycolate enters the peroxisomes where it is converted by glycolate oxidase to glyoxylate which undergoes transamination to glycine. This then passes into the mitochondria where it is decarboxylated forming one molecule of serine for every two molecules of glycine. This pathway also exists in photosynthetic bacteria. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01022403001 19731440 19732022 GO:0009853 photorespiration A light-dependent catabolic process occurring concomitantly with photosynthesis in plants (especially C3 plants) whereby dioxygen (O2) is consumed and carbon dioxide (CO2) is evolved. The substrate is glycolate formed in large quantities in chloroplasts from 2-phosphoglycolate generated from ribulose 1,5-bisphosphate by the action of ribulose-bisphosphate carboxylase; the glycolate enters the peroxisomes where it is converted by glycolate oxidase to glyoxylate which undergoes transamination to glycine. This then passes into the mitochondria where it is decarboxylated forming one molecule of serine for every two molecules of glycine. This pathway also exists in photosynthetic bacteria. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01022403001 19731440 19732022 GO:0009853 photorespiration A light-dependent catabolic process occurring concomitantly with photosynthesis in plants (especially C3 plants) whereby dioxygen (O2) is consumed and carbon dioxide (CO2) is evolved. The substrate is glycolate formed in large quantities in chloroplasts from 2-phosphoglycolate generated from ribulose 1,5-bisphosphate by the action of ribulose-bisphosphate carboxylase; the glycolate enters the peroxisomes where it is converted by glycolate oxidase to glyoxylate which undergoes transamination to glycine. This then passes into the mitochondria where it is decarboxylated forming one molecule of serine for every two molecules of glycine. This pathway also exists in photosynthetic bacteria. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01022403001 19731440 19732022 GO:0015977 carbon fixation A metabolic process in which carbon (usually derived from carbon dioxide) is incorporated into organic compounds (usually carbohydrates). IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01022403001 19731440 19732022 GO:0015977 carbon fixation A metabolic process in which carbon (usually derived from carbon dioxide) is incorporated into organic compounds (usually carbohydrates). IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01022403001 19731440 19732022 GO:0015977 carbon fixation A metabolic process in which carbon (usually derived from carbon dioxide) is incorporated into organic compounds (usually carbohydrates). IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01022403001 19731440 19732022 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01022403001 19731440 19732022 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01022403001 19731440 19732022 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01022403001 19731440 19732022 GO:0019253 reductive pentose-phosphate cycle The fixation of carbon dioxide (CO2) as glucose in the chloroplasts of C3 plants; uses ATP and NADPH formed in the light reactions of photosynthesis; carbon dioxide reacts with ribulose 1,5-bisphosphate (catalyzed by the function of ribulose-bisphosphate carboxylase) to yield two molecules of 3-phosphoglycerate; these are then phosphorylated by ATP to 1,3-bisphosphateglyceraldehyde which, in turn, is then reduced by NADPH to glyceraldehyde 3-phosphate. The glyceraldehyde 3-phosphate is converted to fructose 5-phosphate and ribulose 5-phosphate by aldolase and other enzymes; the ribulose 5-phosphate is phosphorylated by ATP to ribulose 1,5-bisphosphate. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01022403001 19731440 19732022 GO:0019253 reductive pentose-phosphate cycle The fixation of carbon dioxide (CO2) as glucose in the chloroplasts of C3 plants; uses ATP and NADPH formed in the light reactions of photosynthesis; carbon dioxide reacts with ribulose 1,5-bisphosphate (catalyzed by the function of ribulose-bisphosphate carboxylase) to yield two molecules of 3-phosphoglycerate; these are then phosphorylated by ATP to 1,3-bisphosphateglyceraldehyde which, in turn, is then reduced by NADPH to glyceraldehyde 3-phosphate. The glyceraldehyde 3-phosphate is converted to fructose 5-phosphate and ribulose 5-phosphate by aldolase and other enzymes; the ribulose 5-phosphate is phosphorylated by ATP to ribulose 1,5-bisphosphate. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01022403001 19731440 19732022 GO:0019253 reductive pentose-phosphate cycle The fixation of carbon dioxide (CO2) as glucose in the chloroplasts of C3 plants; uses ATP and NADPH formed in the light reactions of photosynthesis; carbon dioxide reacts with ribulose 1,5-bisphosphate (catalyzed by the function of ribulose-bisphosphate carboxylase) to yield two molecules of 3-phosphoglycerate; these are then phosphorylated by ATP to 1,3-bisphosphateglyceraldehyde which, in turn, is then reduced by NADPH to glyceraldehyde 3-phosphate. The glyceraldehyde 3-phosphate is converted to fructose 5-phosphate and ribulose 5-phosphate by aldolase and other enzymes; the ribulose 5-phosphate is phosphorylated by ATP to ribulose 1,5-bisphosphate. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01022403001 19731440 19732022 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01022403001 19731440 19732022 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01022403001 19731440 19732022 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01022403001 19731440 19732022 GO:0009853 photorespiration A light-dependent catabolic process occurring concomitantly with photosynthesis in plants (especially C3 plants) whereby dioxygen (O2) is consumed and carbon dioxide (CO2) is evolved. The substrate is glycolate formed in large quantities in chloroplasts from 2-phosphoglycolate generated from ribulose 1,5-bisphosphate by the action of ribulose-bisphosphate carboxylase; the glycolate enters the peroxisomes where it is converted by glycolate oxidase to glyoxylate which undergoes transamination to glycine. This then passes into the mitochondria where it is decarboxylated forming one molecule of serine for every two molecules of glycine. This pathway also exists in photosynthetic bacteria. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022403001 19731440 19732022 GO:0009853 photorespiration A light-dependent catabolic process occurring concomitantly with photosynthesis in plants (especially C3 plants) whereby dioxygen (O2) is consumed and carbon dioxide (CO2) is evolved. The substrate is glycolate formed in large quantities in chloroplasts from 2-phosphoglycolate generated from ribulose 1,5-bisphosphate by the action of ribulose-bisphosphate carboxylase; the glycolate enters the peroxisomes where it is converted by glycolate oxidase to glyoxylate which undergoes transamination to glycine. This then passes into the mitochondria where it is decarboxylated forming one molecule of serine for every two molecules of glycine. This pathway also exists in photosynthetic bacteria. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022403001 19731440 19732022 GO:0009853 photorespiration A light-dependent catabolic process occurring concomitantly with photosynthesis in plants (especially C3 plants) whereby dioxygen (O2) is consumed and carbon dioxide (CO2) is evolved. The substrate is glycolate formed in large quantities in chloroplasts from 2-phosphoglycolate generated from ribulose 1,5-bisphosphate by the action of ribulose-bisphosphate carboxylase; the glycolate enters the peroxisomes where it is converted by glycolate oxidase to glyoxylate which undergoes transamination to glycine. This then passes into the mitochondria where it is decarboxylated forming one molecule of serine for every two molecules of glycine. This pathway also exists in photosynthetic bacteria. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022403001 19731440 19732022 GO:0015977 carbon fixation A metabolic process in which carbon (usually derived from carbon dioxide) is incorporated into organic compounds (usually carbohydrates). IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022403001 19731440 19732022 GO:0015977 carbon fixation A metabolic process in which carbon (usually derived from carbon dioxide) is incorporated into organic compounds (usually carbohydrates). IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022403001 19731440 19732022 GO:0015977 carbon fixation A metabolic process in which carbon (usually derived from carbon dioxide) is incorporated into organic compounds (usually carbohydrates). IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022403001 19731440 19732022 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022403001 19731440 19732022 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022403001 19731440 19732022 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022403001 19731440 19732022 GO:0019253 reductive pentose-phosphate cycle The fixation of carbon dioxide (CO2) as glucose in the chloroplasts of C3 plants; uses ATP and NADPH formed in the light reactions of photosynthesis; carbon dioxide reacts with ribulose 1,5-bisphosphate (catalyzed by the function of ribulose-bisphosphate carboxylase) to yield two molecules of 3-phosphoglycerate; these are then phosphorylated by ATP to 1,3-bisphosphateglyceraldehyde which, in turn, is then reduced by NADPH to glyceraldehyde 3-phosphate. The glyceraldehyde 3-phosphate is converted to fructose 5-phosphate and ribulose 5-phosphate by aldolase and other enzymes; the ribulose 5-phosphate is phosphorylated by ATP to ribulose 1,5-bisphosphate. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022403001 19731440 19732022 GO:0019253 reductive pentose-phosphate cycle The fixation of carbon dioxide (CO2) as glucose in the chloroplasts of C3 plants; uses ATP and NADPH formed in the light reactions of photosynthesis; carbon dioxide reacts with ribulose 1,5-bisphosphate (catalyzed by the function of ribulose-bisphosphate carboxylase) to yield two molecules of 3-phosphoglycerate; these are then phosphorylated by ATP to 1,3-bisphosphateglyceraldehyde which, in turn, is then reduced by NADPH to glyceraldehyde 3-phosphate. The glyceraldehyde 3-phosphate is converted to fructose 5-phosphate and ribulose 5-phosphate by aldolase and other enzymes; the ribulose 5-phosphate is phosphorylated by ATP to ribulose 1,5-bisphosphate. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022403001 19731440 19732022 GO:0019253 reductive pentose-phosphate cycle The fixation of carbon dioxide (CO2) as glucose in the chloroplasts of C3 plants; uses ATP and NADPH formed in the light reactions of photosynthesis; carbon dioxide reacts with ribulose 1,5-bisphosphate (catalyzed by the function of ribulose-bisphosphate carboxylase) to yield two molecules of 3-phosphoglycerate; these are then phosphorylated by ATP to 1,3-bisphosphateglyceraldehyde which, in turn, is then reduced by NADPH to glyceraldehyde 3-phosphate. The glyceraldehyde 3-phosphate is converted to fructose 5-phosphate and ribulose 5-phosphate by aldolase and other enzymes; the ribulose 5-phosphate is phosphorylated by ATP to ribulose 1,5-bisphosphate. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022403001 19731440 19732022 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022403001 19731440 19732022 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022403001 19731440 19732022 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022403001 19731440 19732022 GO:0009853 photorespiration A light-dependent catabolic process occurring concomitantly with photosynthesis in plants (especially C3 plants) whereby dioxygen (O2) is consumed and carbon dioxide (CO2) is evolved. The substrate is glycolate formed in large quantities in chloroplasts from 2-phosphoglycolate generated from ribulose 1,5-bisphosphate by the action of ribulose-bisphosphate carboxylase; the glycolate enters the peroxisomes where it is converted by glycolate oxidase to glyoxylate which undergoes transamination to glycine. This then passes into the mitochondria where it is decarboxylated forming one molecule of serine for every two molecules of glycine. This pathway also exists in photosynthetic bacteria. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01022403001 19731440 19732022 GO:0009853 photorespiration A light-dependent catabolic process occurring concomitantly with photosynthesis in plants (especially C3 plants) whereby dioxygen (O2) is consumed and carbon dioxide (CO2) is evolved. The substrate is glycolate formed in large quantities in chloroplasts from 2-phosphoglycolate generated from ribulose 1,5-bisphosphate by the action of ribulose-bisphosphate carboxylase; the glycolate enters the peroxisomes where it is converted by glycolate oxidase to glyoxylate which undergoes transamination to glycine. This then passes into the mitochondria where it is decarboxylated forming one molecule of serine for every two molecules of glycine. This pathway also exists in photosynthetic bacteria. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01022403001 19731440 19732022 GO:0009853 photorespiration A light-dependent catabolic process occurring concomitantly with photosynthesis in plants (especially C3 plants) whereby dioxygen (O2) is consumed and carbon dioxide (CO2) is evolved. The substrate is glycolate formed in large quantities in chloroplasts from 2-phosphoglycolate generated from ribulose 1,5-bisphosphate by the action of ribulose-bisphosphate carboxylase; the glycolate enters the peroxisomes where it is converted by glycolate oxidase to glyoxylate which undergoes transamination to glycine. This then passes into the mitochondria where it is decarboxylated forming one molecule of serine for every two molecules of glycine. This pathway also exists in photosynthetic bacteria. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01022403001 19731440 19732022 GO:0015977 carbon fixation A metabolic process in which carbon (usually derived from carbon dioxide) is incorporated into organic compounds (usually carbohydrates). IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01022403001 19731440 19732022 GO:0015977 carbon fixation A metabolic process in which carbon (usually derived from carbon dioxide) is incorporated into organic compounds (usually carbohydrates). IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01022403001 19731440 19732022 GO:0015977 carbon fixation A metabolic process in which carbon (usually derived from carbon dioxide) is incorporated into organic compounds (usually carbohydrates). IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01022403001 19731440 19732022 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01022403001 19731440 19732022 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01022403001 19731440 19732022 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01022403001 19731440 19732022 GO:0019253 reductive pentose-phosphate cycle The fixation of carbon dioxide (CO2) as glucose in the chloroplasts of C3 plants; uses ATP and NADPH formed in the light reactions of photosynthesis; carbon dioxide reacts with ribulose 1,5-bisphosphate (catalyzed by the function of ribulose-bisphosphate carboxylase) to yield two molecules of 3-phosphoglycerate; these are then phosphorylated by ATP to 1,3-bisphosphateglyceraldehyde which, in turn, is then reduced by NADPH to glyceraldehyde 3-phosphate. The glyceraldehyde 3-phosphate is converted to fructose 5-phosphate and ribulose 5-phosphate by aldolase and other enzymes; the ribulose 5-phosphate is phosphorylated by ATP to ribulose 1,5-bisphosphate. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01022403001 19731440 19732022 GO:0019253 reductive pentose-phosphate cycle The fixation of carbon dioxide (CO2) as glucose in the chloroplasts of C3 plants; uses ATP and NADPH formed in the light reactions of photosynthesis; carbon dioxide reacts with ribulose 1,5-bisphosphate (catalyzed by the function of ribulose-bisphosphate carboxylase) to yield two molecules of 3-phosphoglycerate; these are then phosphorylated by ATP to 1,3-bisphosphateglyceraldehyde which, in turn, is then reduced by NADPH to glyceraldehyde 3-phosphate. The glyceraldehyde 3-phosphate is converted to fructose 5-phosphate and ribulose 5-phosphate by aldolase and other enzymes; the ribulose 5-phosphate is phosphorylated by ATP to ribulose 1,5-bisphosphate. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01022403001 19731440 19732022 GO:0019253 reductive pentose-phosphate cycle The fixation of carbon dioxide (CO2) as glucose in the chloroplasts of C3 plants; uses ATP and NADPH formed in the light reactions of photosynthesis; carbon dioxide reacts with ribulose 1,5-bisphosphate (catalyzed by the function of ribulose-bisphosphate carboxylase) to yield two molecules of 3-phosphoglycerate; these are then phosphorylated by ATP to 1,3-bisphosphateglyceraldehyde which, in turn, is then reduced by NADPH to glyceraldehyde 3-phosphate. The glyceraldehyde 3-phosphate is converted to fructose 5-phosphate and ribulose 5-phosphate by aldolase and other enzymes; the ribulose 5-phosphate is phosphorylated by ATP to ribulose 1,5-bisphosphate. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01022403001 19731440 19732022 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01022403001 19731440 19732022 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01022403001 19731440 19732022 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01022403001 19731440 19732022 GO:0009853 photorespiration A light-dependent catabolic process occurring concomitantly with photosynthesis in plants (especially C3 plants) whereby dioxygen (O2) is consumed and carbon dioxide (CO2) is evolved. The substrate is glycolate formed in large quantities in chloroplasts from 2-phosphoglycolate generated from ribulose 1,5-bisphosphate by the action of ribulose-bisphosphate carboxylase; the glycolate enters the peroxisomes where it is converted by glycolate oxidase to glyoxylate which undergoes transamination to glycine. This then passes into the mitochondria where it is decarboxylated forming one molecule of serine for every two molecules of glycine. This pathway also exists in photosynthetic bacteria. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of the reaction: D-ribulose 1,5-bisphosphate + CO2 + H2O = 2 3-phospho-D-glycerate. IEA GO:0016984 ribulose-bisphosphate carboxylase activity GSVIVG01022403001 19731440 19732022 GO:0009853 photorespiration A light-dependent catabolic process occurring concomitantly with photosynthesis in plants (especially C3 plants) whereby dioxygen (O2) is consumed and carbon dioxide (CO2) is evolved. The substrate is glycolate formed in large quantities in chloroplasts from 2-phosphoglycolate generated from ribulose 1,5-bisphosphate by the action of ribulose-bisphosphate carboxylase; the glycolate enters the peroxisomes where it is converted by glycolate oxidase to glyoxylate which undergoes transamination to glycine. This then passes into the mitochondria where it is decarboxylated forming one molecule of serine for every two molecules of glycine. This pathway also exists in photosynthetic bacteria. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of the reaction: D-ribulose 1,5-bisphosphate + CO2 + H2O = 2 3-phospho-D-glycerate. IEA GO:0016984 ribulose-bisphosphate carboxylase activity GSVIVG01022403001 19731440 19732022 GO:0009853 photorespiration A light-dependent catabolic process occurring concomitantly with photosynthesis in plants (especially C3 plants) whereby dioxygen (O2) is consumed and carbon dioxide (CO2) is evolved. The substrate is glycolate formed in large quantities in chloroplasts from 2-phosphoglycolate generated from ribulose 1,5-bisphosphate by the action of ribulose-bisphosphate carboxylase; the glycolate enters the peroxisomes where it is converted by glycolate oxidase to glyoxylate which undergoes transamination to glycine. This then passes into the mitochondria where it is decarboxylated forming one molecule of serine for every two molecules of glycine. This pathway also exists in photosynthetic bacteria. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Catalysis of the reaction: D-ribulose 1,5-bisphosphate + CO2 + H2O = 2 3-phospho-D-glycerate. IEA GO:0016984 ribulose-bisphosphate carboxylase activity GSVIVG01022403001 19731440 19732022 GO:0015977 carbon fixation A metabolic process in which carbon (usually derived from carbon dioxide) is incorporated into organic compounds (usually carbohydrates). IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of the reaction: D-ribulose 1,5-bisphosphate + CO2 + H2O = 2 3-phospho-D-glycerate. IEA GO:0016984 ribulose-bisphosphate carboxylase activity GSVIVG01022403001 19731440 19732022 GO:0015977 carbon fixation A metabolic process in which carbon (usually derived from carbon dioxide) is incorporated into organic compounds (usually carbohydrates). IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of the reaction: D-ribulose 1,5-bisphosphate + CO2 + H2O = 2 3-phospho-D-glycerate. IEA GO:0016984 ribulose-bisphosphate carboxylase activity GSVIVG01022403001 19731440 19732022 GO:0015977 carbon fixation A metabolic process in which carbon (usually derived from carbon dioxide) is incorporated into organic compounds (usually carbohydrates). IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Catalysis of the reaction: D-ribulose 1,5-bisphosphate + CO2 + H2O = 2 3-phospho-D-glycerate. IEA GO:0016984 ribulose-bisphosphate carboxylase activity GSVIVG01022403001 19731440 19732022 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of the reaction: D-ribulose 1,5-bisphosphate + CO2 + H2O = 2 3-phospho-D-glycerate. IEA GO:0016984 ribulose-bisphosphate carboxylase activity GSVIVG01022403001 19731440 19732022 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of the reaction: D-ribulose 1,5-bisphosphate + CO2 + H2O = 2 3-phospho-D-glycerate. IEA GO:0016984 ribulose-bisphosphate carboxylase activity GSVIVG01022403001 19731440 19732022 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Catalysis of the reaction: D-ribulose 1,5-bisphosphate + CO2 + H2O = 2 3-phospho-D-glycerate. IEA GO:0016984 ribulose-bisphosphate carboxylase activity GSVIVG01022403001 19731440 19732022 GO:0019253 reductive pentose-phosphate cycle The fixation of carbon dioxide (CO2) as glucose in the chloroplasts of C3 plants; uses ATP and NADPH formed in the light reactions of photosynthesis; carbon dioxide reacts with ribulose 1,5-bisphosphate (catalyzed by the function of ribulose-bisphosphate carboxylase) to yield two molecules of 3-phosphoglycerate; these are then phosphorylated by ATP to 1,3-bisphosphateglyceraldehyde which, in turn, is then reduced by NADPH to glyceraldehyde 3-phosphate. The glyceraldehyde 3-phosphate is converted to fructose 5-phosphate and ribulose 5-phosphate by aldolase and other enzymes; the ribulose 5-phosphate is phosphorylated by ATP to ribulose 1,5-bisphosphate. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of the reaction: D-ribulose 1,5-bisphosphate + CO2 + H2O = 2 3-phospho-D-glycerate. IEA GO:0016984 ribulose-bisphosphate carboxylase activity GSVIVG01022403001 19731440 19732022 GO:0019253 reductive pentose-phosphate cycle The fixation of carbon dioxide (CO2) as glucose in the chloroplasts of C3 plants; uses ATP and NADPH formed in the light reactions of photosynthesis; carbon dioxide reacts with ribulose 1,5-bisphosphate (catalyzed by the function of ribulose-bisphosphate carboxylase) to yield two molecules of 3-phosphoglycerate; these are then phosphorylated by ATP to 1,3-bisphosphateglyceraldehyde which, in turn, is then reduced by NADPH to glyceraldehyde 3-phosphate. The glyceraldehyde 3-phosphate is converted to fructose 5-phosphate and ribulose 5-phosphate by aldolase and other enzymes; the ribulose 5-phosphate is phosphorylated by ATP to ribulose 1,5-bisphosphate. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of the reaction: D-ribulose 1,5-bisphosphate + CO2 + H2O = 2 3-phospho-D-glycerate. IEA GO:0016984 ribulose-bisphosphate carboxylase activity GSVIVG01022403001 19731440 19732022 GO:0019253 reductive pentose-phosphate cycle The fixation of carbon dioxide (CO2) as glucose in the chloroplasts of C3 plants; uses ATP and NADPH formed in the light reactions of photosynthesis; carbon dioxide reacts with ribulose 1,5-bisphosphate (catalyzed by the function of ribulose-bisphosphate carboxylase) to yield two molecules of 3-phosphoglycerate; these are then phosphorylated by ATP to 1,3-bisphosphateglyceraldehyde which, in turn, is then reduced by NADPH to glyceraldehyde 3-phosphate. The glyceraldehyde 3-phosphate is converted to fructose 5-phosphate and ribulose 5-phosphate by aldolase and other enzymes; the ribulose 5-phosphate is phosphorylated by ATP to ribulose 1,5-bisphosphate. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Catalysis of the reaction: D-ribulose 1,5-bisphosphate + CO2 + H2O = 2 3-phospho-D-glycerate. IEA GO:0016984 ribulose-bisphosphate carboxylase activity GSVIVG01022403001 19731440 19732022 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of the reaction: D-ribulose 1,5-bisphosphate + CO2 + H2O = 2 3-phospho-D-glycerate. IEA GO:0016984 ribulose-bisphosphate carboxylase activity GSVIVG01022403001 19731440 19732022 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of the reaction: D-ribulose 1,5-bisphosphate + CO2 + H2O = 2 3-phospho-D-glycerate. IEA GO:0016984 ribulose-bisphosphate carboxylase activity GSVIVG01022403001 19731440 19732022 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Catalysis of the reaction: D-ribulose 1,5-bisphosphate + CO2 + H2O = 2 3-phospho-D-glycerate. IEA GO:0016984 ribulose-bisphosphate carboxylase activity GSVIVG01022403001 19731440 19732022 GO:0009853 photorespiration A light-dependent catabolic process occurring concomitantly with photosynthesis in plants (especially C3 plants) whereby dioxygen (O2) is consumed and carbon dioxide (CO2) is evolved. The substrate is glycolate formed in large quantities in chloroplasts from 2-phosphoglycolate generated from ribulose 1,5-bisphosphate by the action of ribulose-bisphosphate carboxylase; the glycolate enters the peroxisomes where it is converted by glycolate oxidase to glyoxylate which undergoes transamination to glycine. This then passes into the mitochondria where it is decarboxylated forming one molecule of serine for every two molecules of glycine. This pathway also exists in photosynthetic bacteria. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01022403001 19731440 19732022 GO:0009853 photorespiration A light-dependent catabolic process occurring concomitantly with photosynthesis in plants (especially C3 plants) whereby dioxygen (O2) is consumed and carbon dioxide (CO2) is evolved. The substrate is glycolate formed in large quantities in chloroplasts from 2-phosphoglycolate generated from ribulose 1,5-bisphosphate by the action of ribulose-bisphosphate carboxylase; the glycolate enters the peroxisomes where it is converted by glycolate oxidase to glyoxylate which undergoes transamination to glycine. This then passes into the mitochondria where it is decarboxylated forming one molecule of serine for every two molecules of glycine. This pathway also exists in photosynthetic bacteria. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01022403001 19731440 19732022 GO:0009853 photorespiration A light-dependent catabolic process occurring concomitantly with photosynthesis in plants (especially C3 plants) whereby dioxygen (O2) is consumed and carbon dioxide (CO2) is evolved. The substrate is glycolate formed in large quantities in chloroplasts from 2-phosphoglycolate generated from ribulose 1,5-bisphosphate by the action of ribulose-bisphosphate carboxylase; the glycolate enters the peroxisomes where it is converted by glycolate oxidase to glyoxylate which undergoes transamination to glycine. This then passes into the mitochondria where it is decarboxylated forming one molecule of serine for every two molecules of glycine. This pathway also exists in photosynthetic bacteria. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01022403001 19731440 19732022 GO:0015977 carbon fixation A metabolic process in which carbon (usually derived from carbon dioxide) is incorporated into organic compounds (usually carbohydrates). IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01022403001 19731440 19732022 GO:0015977 carbon fixation A metabolic process in which carbon (usually derived from carbon dioxide) is incorporated into organic compounds (usually carbohydrates). IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01022403001 19731440 19732022 GO:0015977 carbon fixation A metabolic process in which carbon (usually derived from carbon dioxide) is incorporated into organic compounds (usually carbohydrates). IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01022403001 19731440 19732022 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01022403001 19731440 19732022 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01022403001 19731440 19732022 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01022403001 19731440 19732022 GO:0019253 reductive pentose-phosphate cycle The fixation of carbon dioxide (CO2) as glucose in the chloroplasts of C3 plants; uses ATP and NADPH formed in the light reactions of photosynthesis; carbon dioxide reacts with ribulose 1,5-bisphosphate (catalyzed by the function of ribulose-bisphosphate carboxylase) to yield two molecules of 3-phosphoglycerate; these are then phosphorylated by ATP to 1,3-bisphosphateglyceraldehyde which, in turn, is then reduced by NADPH to glyceraldehyde 3-phosphate. The glyceraldehyde 3-phosphate is converted to fructose 5-phosphate and ribulose 5-phosphate by aldolase and other enzymes; the ribulose 5-phosphate is phosphorylated by ATP to ribulose 1,5-bisphosphate. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01022403001 19731440 19732022 GO:0019253 reductive pentose-phosphate cycle The fixation of carbon dioxide (CO2) as glucose in the chloroplasts of C3 plants; uses ATP and NADPH formed in the light reactions of photosynthesis; carbon dioxide reacts with ribulose 1,5-bisphosphate (catalyzed by the function of ribulose-bisphosphate carboxylase) to yield two molecules of 3-phosphoglycerate; these are then phosphorylated by ATP to 1,3-bisphosphateglyceraldehyde which, in turn, is then reduced by NADPH to glyceraldehyde 3-phosphate. The glyceraldehyde 3-phosphate is converted to fructose 5-phosphate and ribulose 5-phosphate by aldolase and other enzymes; the ribulose 5-phosphate is phosphorylated by ATP to ribulose 1,5-bisphosphate. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01022403001 19731440 19732022 GO:0019253 reductive pentose-phosphate cycle The fixation of carbon dioxide (CO2) as glucose in the chloroplasts of C3 plants; uses ATP and NADPH formed in the light reactions of photosynthesis; carbon dioxide reacts with ribulose 1,5-bisphosphate (catalyzed by the function of ribulose-bisphosphate carboxylase) to yield two molecules of 3-phosphoglycerate; these are then phosphorylated by ATP to 1,3-bisphosphateglyceraldehyde which, in turn, is then reduced by NADPH to glyceraldehyde 3-phosphate. The glyceraldehyde 3-phosphate is converted to fructose 5-phosphate and ribulose 5-phosphate by aldolase and other enzymes; the ribulose 5-phosphate is phosphorylated by ATP to ribulose 1,5-bisphosphate. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01022403001 19731440 19732022 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01022403001 19731440 19732022 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01022403001 19731440 19732022 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01009466001 8600989 8605039 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01009466001 8600989 8605039 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01009466001 8600989 8605039 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01029843001 333861 338863 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01029843001 333861 338863 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01029843001 333861 338863 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01029843001 333861 338863 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029843001 333861 338863 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01029525001 21957164 21976115 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029525001 21957164 21976115 Catalysis of the transfer of a functional group from one position to another within a single molecule. IEA GO:0016866 intramolecular transferase activity GSVIVG01010916001 15746499 15747761 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01010916001 15746499 15747761 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016692001 402372 404698 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01016692001 402372 404698 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01035148001 1910248 1911449 Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01033706001 18459916 18461377 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01018428001 9128671 9134686 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01018428001 9128671 9134686 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01018428001 9128671 9134686 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01018428001 9128671 9134686 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01019311001 1423198 1428786 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01003135001 7539372 7542856 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01028057001 3495915 3498855 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01016893001 2348280 2351950 GSVIVG01012243001 263082 269275 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01012243001 263082 269275 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01012243001 263082 269275 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01012243001 263082 269275 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01009286001 6978724 6992744 Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01013494001 1831807 1842808 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01013494001 1831807 1842808 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01013494001 1831807 1842808 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01013494001 1831807 1842808 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013494001 1831807 1842808 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013494001 1831807 1842808 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01016558001 2798646 2801743 GSVIVG01027030001 18487999 18490950 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036273001 7645335 7647273 GSVIVG01027593001 15225095 15231560 GO:0006875 cellular metal ion homeostasis Any process involved in the maintenance of an internal steady-state of metal ions at the level of a cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01027593001 15225095 15231560 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01027593001 15225095 15231560 GO:0006875 cellular metal ion homeostasis Any process involved in the maintenance of an internal steady-state of metal ions at the level of a cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027593001 15225095 15231560 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027593001 15225095 15231560 GO:0006875 cellular metal ion homeostasis Any process involved in the maintenance of an internal steady-state of metal ions at the level of a cell. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01027593001 15225095 15231560 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01027593001 15225095 15231560 GO:0006875 cellular metal ion homeostasis Any process involved in the maintenance of an internal steady-state of metal ions at the level of a cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01027593001 15225095 15231560 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01010020001 13511611 13520058 GSVIVG01018178001 13514010 13597648 GSVIVG01038168001 24039534 24041325 GSVIVG01028706001 19588381 19600987 Catalysis of the transfer of a nucleotidyl group to a reactant. IEA GO:0016779 nucleotidyltransferase activity GSVIVG01016517001 3197303 3207623 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01006155001 42204458 42205981 GSVIVG01001488001 5088243 5098646 GSVIVG01006154001 42192918 42195168 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01008684001 1192883 1202960 GSVIVG01004940001 21696690 21699186 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01016418001 4108664 4109146 GSVIVG01016652001 122429 139325 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016652001 122429 139325 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016652001 122429 139325 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016652001 122429 139325 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016652001 122429 139325 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016652001 122429 139325 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016652001 122429 139325 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016652001 122429 139325 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016652001 122429 139325 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016652001 122429 139325 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016652001 122429 139325 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016652001 122429 139325 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016652001 122429 139325 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01016652001 122429 139325 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01016652001 122429 139325 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01016652001 122429 139325 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01016652001 122429 139325 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01016652001 122429 139325 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01016652001 122429 139325 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01016652001 122429 139325 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01016652001 122429 139325 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01016652001 122429 139325 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01016652001 122429 139325 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01016652001 122429 139325 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01016652001 122429 139325 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01016652001 122429 139325 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01016652001 122429 139325 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01016652001 122429 139325 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01016652001 122429 139325 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01016652001 122429 139325 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01002807001 36590940 36592951 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01002807001 36590940 36592951 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01008156001 5240730 5241938 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01008156001 5240730 5241938 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the synthesis of a short RNA primer on a DNA template, providing a free 3'-OH that can be extended by DNA-directed DNA polymerases. Catalyzed by a DNA-directed RNA polymerase that forms a complex with alpha DNA polymerase. IEA GO:0003896 DNA primase activity GSVIVG01008156001 5240730 5241938 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01008156001 5240730 5241938 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01001818001 26066284 26070962 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA GSVIVG01001818001 26066284 26070962 GO:0006415 translational termination The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code). IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA GSVIVG01018769001 20085218 20086815 GSVIVG01031069001 21799921 21806406 GSVIVG01012853001 6174292 6181906 GO:0006171 cAMP biosynthetic process The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). IEA Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate. IEA GO:0004016 adenylate cyclase activity GSVIVG01031021001 21048751 21060054 GSVIVG01033352001 21268511 21282356 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033352001 21268511 21282356 GO:0008360 regulation of cell shape Any process that modulates the surface configuration of a cell. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033352001 21268511 21282356 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033352001 21268511 21282356 GO:0009252 peptidoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033352001 21268511 21282356 GO:0009273 peptidoglycan-based cell wall biogenesis The chemical reactions and pathways resulting in the formation of the peptidoglycan-based cell wall. An example of this process is found in Escherichia coli. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033352001 21268511 21282356 GO:0009396 folic acid and derivative biosynthetic process The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033352001 21268511 21282356 GO:0051301 cell division The process resulting in the physical partitioning and separation of a cell into daughter cells. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033352001 21268511 21282356 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033352001 21268511 21282356 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1). IEA GO:0004326 tetrahydrofolylpolyglutamate synthase activity GSVIVG01033352001 21268511 21282356 GO:0008360 regulation of cell shape Any process that modulates the surface configuration of a cell. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1). IEA GO:0004326 tetrahydrofolylpolyglutamate synthase activity GSVIVG01033352001 21268511 21282356 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1). IEA GO:0004326 tetrahydrofolylpolyglutamate synthase activity GSVIVG01033352001 21268511 21282356 GO:0009252 peptidoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1). IEA GO:0004326 tetrahydrofolylpolyglutamate synthase activity GSVIVG01033352001 21268511 21282356 GO:0009273 peptidoglycan-based cell wall biogenesis The chemical reactions and pathways resulting in the formation of the peptidoglycan-based cell wall. An example of this process is found in Escherichia coli. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1). IEA GO:0004326 tetrahydrofolylpolyglutamate synthase activity GSVIVG01033352001 21268511 21282356 GO:0009396 folic acid and derivative biosynthetic process The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1). IEA GO:0004326 tetrahydrofolylpolyglutamate synthase activity GSVIVG01033352001 21268511 21282356 GO:0051301 cell division The process resulting in the physical partitioning and separation of a cell into daughter cells. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1). IEA GO:0004326 tetrahydrofolylpolyglutamate synthase activity GSVIVG01033352001 21268511 21282356 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1). IEA GO:0004326 tetrahydrofolylpolyglutamate synthase activity GSVIVG01033352001 21268511 21282356 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01033352001 21268511 21282356 GO:0008360 regulation of cell shape Any process that modulates the surface configuration of a cell. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01033352001 21268511 21282356 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01033352001 21268511 21282356 GO:0009252 peptidoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01033352001 21268511 21282356 GO:0009273 peptidoglycan-based cell wall biogenesis The chemical reactions and pathways resulting in the formation of the peptidoglycan-based cell wall. An example of this process is found in Escherichia coli. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01033352001 21268511 21282356 GO:0009396 folic acid and derivative biosynthetic process The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01033352001 21268511 21282356 GO:0051301 cell division The process resulting in the physical partitioning and separation of a cell into daughter cells. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01033352001 21268511 21282356 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01033352001 21268511 21282356 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033352001 21268511 21282356 GO:0008360 regulation of cell shape Any process that modulates the surface configuration of a cell. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033352001 21268511 21282356 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033352001 21268511 21282356 GO:0009252 peptidoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033352001 21268511 21282356 GO:0009273 peptidoglycan-based cell wall biogenesis The chemical reactions and pathways resulting in the formation of the peptidoglycan-based cell wall. An example of this process is found in Escherichia coli. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033352001 21268511 21282356 GO:0009396 folic acid and derivative biosynthetic process The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033352001 21268511 21282356 GO:0051301 cell division The process resulting in the physical partitioning and separation of a cell into daughter cells. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033352001 21268511 21282356 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033352001 21268511 21282356 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033352001 21268511 21282356 GO:0008360 regulation of cell shape Any process that modulates the surface configuration of a cell. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033352001 21268511 21282356 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033352001 21268511 21282356 GO:0009252 peptidoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033352001 21268511 21282356 GO:0009273 peptidoglycan-based cell wall biogenesis The chemical reactions and pathways resulting in the formation of the peptidoglycan-based cell wall. An example of this process is found in Escherichia coli. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033352001 21268511 21282356 GO:0009396 folic acid and derivative biosynthetic process The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033352001 21268511 21282356 GO:0051301 cell division The process resulting in the physical partitioning and separation of a cell into daughter cells. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033352001 21268511 21282356 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033352001 21268511 21282356 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + UDP-N-acetylmuramoyl-L-alanine + D-glutamate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate. IEA GO:0008764 UDP-N-acetylmuramoylalanine-D-glutamate ligase activity GSVIVG01033352001 21268511 21282356 GO:0008360 regulation of cell shape Any process that modulates the surface configuration of a cell. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + UDP-N-acetylmuramoyl-L-alanine + D-glutamate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate. IEA GO:0008764 UDP-N-acetylmuramoylalanine-D-glutamate ligase activity GSVIVG01033352001 21268511 21282356 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + UDP-N-acetylmuramoyl-L-alanine + D-glutamate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate. IEA GO:0008764 UDP-N-acetylmuramoylalanine-D-glutamate ligase activity GSVIVG01033352001 21268511 21282356 GO:0009252 peptidoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + UDP-N-acetylmuramoyl-L-alanine + D-glutamate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate. IEA GO:0008764 UDP-N-acetylmuramoylalanine-D-glutamate ligase activity GSVIVG01033352001 21268511 21282356 GO:0009273 peptidoglycan-based cell wall biogenesis The chemical reactions and pathways resulting in the formation of the peptidoglycan-based cell wall. An example of this process is found in Escherichia coli. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + UDP-N-acetylmuramoyl-L-alanine + D-glutamate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate. IEA GO:0008764 UDP-N-acetylmuramoylalanine-D-glutamate ligase activity GSVIVG01033352001 21268511 21282356 GO:0009396 folic acid and derivative biosynthetic process The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + UDP-N-acetylmuramoyl-L-alanine + D-glutamate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate. IEA GO:0008764 UDP-N-acetylmuramoylalanine-D-glutamate ligase activity GSVIVG01033352001 21268511 21282356 GO:0051301 cell division The process resulting in the physical partitioning and separation of a cell into daughter cells. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + UDP-N-acetylmuramoyl-L-alanine + D-glutamate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate. IEA GO:0008764 UDP-N-acetylmuramoylalanine-D-glutamate ligase activity GSVIVG01033352001 21268511 21282356 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + UDP-N-acetylmuramoyl-L-alanine + D-glutamate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate. IEA GO:0008764 UDP-N-acetylmuramoylalanine-D-glutamate ligase activity GSVIVG01033352001 21268511 21282356 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01033352001 21268511 21282356 GO:0008360 regulation of cell shape Any process that modulates the surface configuration of a cell. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01033352001 21268511 21282356 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01033352001 21268511 21282356 GO:0009252 peptidoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01033352001 21268511 21282356 GO:0009273 peptidoglycan-based cell wall biogenesis The chemical reactions and pathways resulting in the formation of the peptidoglycan-based cell wall. An example of this process is found in Escherichia coli. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01033352001 21268511 21282356 GO:0009396 folic acid and derivative biosynthetic process The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01033352001 21268511 21282356 GO:0051301 cell division The process resulting in the physical partitioning and separation of a cell into daughter cells. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01033352001 21268511 21282356 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01033352001 21268511 21282356 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01033352001 21268511 21282356 GO:0008360 regulation of cell shape Any process that modulates the surface configuration of a cell. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01033352001 21268511 21282356 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01033352001 21268511 21282356 GO:0009252 peptidoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01033352001 21268511 21282356 GO:0009273 peptidoglycan-based cell wall biogenesis The chemical reactions and pathways resulting in the formation of the peptidoglycan-based cell wall. An example of this process is found in Escherichia coli. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01033352001 21268511 21282356 GO:0009396 folic acid and derivative biosynthetic process The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01033352001 21268511 21282356 GO:0051301 cell division The process resulting in the physical partitioning and separation of a cell into daughter cells. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01033352001 21268511 21282356 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01033352001 21268511 21282356 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01033352001 21268511 21282356 GO:0008360 regulation of cell shape Any process that modulates the surface configuration of a cell. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01033352001 21268511 21282356 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01033352001 21268511 21282356 GO:0009252 peptidoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01033352001 21268511 21282356 GO:0009273 peptidoglycan-based cell wall biogenesis The chemical reactions and pathways resulting in the formation of the peptidoglycan-based cell wall. An example of this process is found in Escherichia coli. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01033352001 21268511 21282356 GO:0009396 folic acid and derivative biosynthetic process The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01033352001 21268511 21282356 GO:0051301 cell division The process resulting in the physical partitioning and separation of a cell into daughter cells. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01033352001 21268511 21282356 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01018678001 11247840 11248951 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01021902001 5837017 5837292 GSVIVG01033630001 19109487 19113747 GSVIVG01031348001 156573 157231 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005643 nuclear pore Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined. IEA GSVIVG01004520001 38997995 38998799 GSVIVG01023975001 1967318 1978417 GSVIVG01023526001 10279104 10296477 GSVIVG01026460001 23227160 23228312 GSVIVG01024625001 8281283 8286829 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01024625001 8281283 8286829 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01024625001 8281283 8286829 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01024625001 8281283 8286829 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01024625001 8281283 8286829 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01024625001 8281283 8286829 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01038231001 24509683 24515160 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01038231001 24509683 24515160 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01038231001 24509683 24515160 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01038231001 24509683 24515160 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01030193001 10661674 10674386 GSVIVG01001869001 317201 357188 GSVIVG01015641001 14652187 14683330 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01015641001 14652187 14683330 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01019486001 1047976 1048904 Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01019486001 1047976 1048904 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01025782001 11923426 11925207 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. IEA GO:0004364 glutathione transferase activity GSVIVG01017384001 7657421 7657591 GSVIVG01035515001 1931740 1932417 GSVIVG01005197001 19076988 19080950 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01005197001 19076988 19080950 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01021657001 8826950 8827727 GSVIVG01031449001 18393087 18401930 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031449001 18393087 18401930 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01005110001 18187943 18188182 GSVIVG01027214001 18108962 18111622 GSVIVG01032678001 1585577 1588673 GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA GSVIVG01020055001 11013835 11016961 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01020055001 11013835 11016961 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01020055001 11013835 11016961 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01020055001 11013835 11016961 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020055001 11013835 11016961 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022690001 15082861 15087289 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. IEA GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GSVIVG01023420001 12342664 12343816 GSVIVG01011492001 30026339 30030404 GSVIVG01025123001 4235377 4240476 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation Splicing of tRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons. IEA Catalysis of the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron. IEA GO:0000213 tRNA-intron endonuclease activity GSVIVG01025123001 4235377 4240476 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation Splicing of tRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01025123001 4235377 4240476 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation Splicing of tRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids. IEA GO:0004518 nuclease activity GSVIVG01020005001 11722267 11730200 GSVIVG01027665001 14515341 14520389 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01027665001 14515341 14520389 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01027665001 14515341 14520389 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01027665001 14515341 14520389 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027665001 14515341 14520389 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate in the presence of single- or double-stranded DNA; drives another reaction. IEA GO:0008094 DNA-dependent ATPase activity GSVIVG01027665001 14515341 14520389 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01034194001 14520517 14521395 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015817001 17828186 17835444 GO:0009405 pathogenesis The set of specific processes that generate the ability of an organism to cause disease in another. IEA GSVIVG01029503001 22229193 22233488 GSVIVG01018944001 18489566 18491019 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01017619001 2065147 2066133 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005773 vacuole A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol. IEA Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain. IEA GO:0004177 aminopeptidase activity GSVIVG01017619001 2065147 2066133 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005773 vacuole A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01019975001 12128655 12130442 GSVIVG01012113001 1336618 1340485 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012113001 1336618 1340485 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012113001 1336618 1340485 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012113001 1336618 1340485 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012113001 1336618 1340485 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01012113001 1336618 1340485 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01012113001 1336618 1340485 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01012113001 1336618 1340485 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01012113001 1336618 1340485 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01012113001 1336618 1340485 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01012113001 1336618 1340485 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01012113001 1336618 1340485 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01012113001 1336618 1340485 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01012113001 1336618 1340485 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01012113001 1336618 1340485 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01012113001 1336618 1340485 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01012113001 1336618 1340485 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01012113001 1336618 1340485 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01012113001 1336618 1340485 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01012113001 1336618 1340485 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01012113001 1336618 1340485 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01012113001 1336618 1340485 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01012113001 1336618 1340485 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01012113001 1336618 1340485 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01032006001 23631929 23637358 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032006001 23631929 23637358 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01032006001 23631929 23637358 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01024723001 7450402 7456800 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01024723001 7450402 7456800 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033697001 18509389 18510573 GSVIVG01021483001 6013550 6014808 GSVIVG01038623001 21384984 21390817 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01038623001 21384984 21390817 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01038623001 21384984 21390817 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01038623001 21384984 21390817 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01038623001 21384984 21390817 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01038623001 21384984 21390817 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012978001 10849883 10851759 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01018309001 11276430 11290149 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). IEA GO:0003755 peptidyl-prolyl cis-trans isomerase activity GSVIVG01009262001 6793814 6796181 GSVIVG01004869001 16225520 16226197 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000063001 3182659 3184069 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with manganese (Mn) ions. IEA GO:0030145 manganese ion binding GSVIVG01000063001 3182659 3184069 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Functions in the storage of nutritious substrates. IEA GO:0045735 nutrient reservoir activity GSVIVG01000063001 3182659 3184069 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01008198001 4771399 4773002 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01022805001 16795324 16798580 GSVIVG01014110001 481019 491501 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014110001 481019 491501 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014110001 481019 491501 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014110001 481019 491501 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014110001 481019 491501 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020854001 995099 1078999 GO:0006075 1,3-beta-glucan biosynthetic process The chemical reactions and pathways resulting in the formation of beta-1,3 glucans, compounds composed of glucose residues linked by 1,3-beta-D-glucosidic bonds. IEA GO:0000148 1,3-beta-glucan synthase complex A protein complex that catalyzes the transfer of a glucose moiety from UDP-glucose to a 1,3-beta-D-glucan chain. IEA Catalysis of the reaction: UDP-glucose + 1,3-beta-D-glucosyl(n) = UDP + 1,3-beta-D-glucosyl(n+1). IEA GO:0003843 1,3-beta-glucan synthase activity GSVIVG01020854001 995099 1078999 GO:0006075 1,3-beta-glucan biosynthetic process The chemical reactions and pathways resulting in the formation of beta-1,3 glucans, compounds composed of glucose residues linked by 1,3-beta-D-glucosidic bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: UDP-glucose + 1,3-beta-D-glucosyl(n) = UDP + 1,3-beta-D-glucosyl(n+1). IEA GO:0003843 1,3-beta-glucan synthase activity GSVIVG01024127001 897891 898178 GSVIVG01026113001 24442335 24449932 GSVIVG01027003001 18639469 18647029 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01027003001 18639469 18647029 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01027003001 18639469 18647029 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01027003001 18639469 18647029 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01027003001 18639469 18647029 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01027003001 18639469 18647029 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01010223001 17879905 17881773 GSVIVG01032233001 13509504 13529426 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA Catalysis of the reaction: ADP-glucose + (1,4)-alpha-D-glucosyl(n) = ADP + (1,4)-alpha-D-glucosyl(n+1). IEA GO:0009011 starch synthase activity GSVIVG01032233001 13509504 13529426 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: ADP-glucose + (1,4)-alpha-D-glucosyl(n) = ADP + (1,4)-alpha-D-glucosyl(n+1). IEA GO:0009011 starch synthase activity GSVIVG01032233001 13509504 13529426 GO:0009250 glucan biosynthetic process The chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues. IEA Catalysis of the reaction: ADP-glucose + (1,4)-alpha-D-glucosyl(n) = ADP + (1,4)-alpha-D-glucosyl(n+1). IEA GO:0009011 starch synthase activity GSVIVG01027513001 16064252 16067914 GSVIVG01024950001 5736016 5739521 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01024950001 5736016 5739521 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01024950001 5736016 5739521 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01024950001 5736016 5739521 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019653001 2231721 2233589 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01019653001 2231721 2233589 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01019653001 2231721 2233589 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01019653001 2231721 2233589 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01035719001 3642861 3645919 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0000159 protein phosphatase type 2A complex A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit. IEA Modulation of the activity of the enzyme protein phosphatase type 2A. IEA GO:0008601 protein phosphatase type 2A regulator activity GSVIVG01027438001 16709045 16729207 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027438001 16709045 16729207 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01027438001 16709045 16729207 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01032451001 27537699 27544536 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01032451001 27537699 27544536 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01032451001 27537699 27544536 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01032451001 27537699 27544536 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01032451001 27537699 27544536 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01032451001 27537699 27544536 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01032451001 27537699 27544536 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01032451001 27537699 27544536 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01032451001 27537699 27544536 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate. IEA GO:0019001 guanyl nucleotide binding GSVIVG01032451001 27537699 27544536 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate. IEA GO:0019001 guanyl nucleotide binding GSVIVG01032451001 27537699 27544536 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate. IEA GO:0019001 guanyl nucleotide binding GSVIVG01032451001 27537699 27544536 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate. IEA GO:0019001 guanyl nucleotide binding GSVIVG01017666001 2487510 2488654 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage. IEA GO:0016209 antioxidant activity GSVIVG01017666001 2487510 2488654 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01027532001 15953148 15959210 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01027532001 15953148 15959210 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01017280001 6294173 6300759 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01017280001 6294173 6300759 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA Catalysis of the reaction: formyl-L-methionyl peptide + H2O = formate + methionyl peptide. IEA GO:0042586 peptide deformylase activity GSVIVG01034068001 15425418 15433744 GSVIVG01029530001 21902965 21913480 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01029530001 21902965 21913480 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01029530001 21902965 21913480 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01029530001 21902965 21913480 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01029530001 21902965 21913480 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01029530001 21902965 21913480 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01029530001 21902965 21913480 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029530001 21902965 21913480 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011694001 5078518 5079633 GSVIVG01023340001 19563591 19568416 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01025911001 27319002 27324143 GSVIVG01009018001 4326000 4329435 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with lysosphingolipid or lysophosphatidic acid to initiate a change in cell activity. IEA GO:0001619 lysosphingolipid and lysophosphatidic acid receptor activity GSVIVG01012321001 31910 33889 GSVIVG01014754001 9268237 9268866 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035863001 5004885 5006018 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar. IEA GO:0008375 acetylglucosaminyltransferase activity GSVIVG01031052001 21468051 21469322 GSVIVG01007327001 31383089 31393726 GSVIVG01009597001 9748670 9752634 GSVIVG01007724001 9899395 9906902 GO:0007154 cell communication Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01007724001 9899395 9906902 GO:0007154 cell communication Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. IEA Interacting selectively and non-covalently with any inositol-containing glycerophospholipid. Phosphatidylinositol (PtdIns) and its phosphorylated derivatives are collectively referred to as phosphoinositides (PIs). IEA GO:0035091 phosphoinositide binding GSVIVG01007586001 11622796 11629827 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01007586001 11622796 11629827 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01007586001 11622796 11629827 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007586001 11622796 11629827 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007586001 11622796 11629827 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01007586001 11622796 11629827 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01007586001 11622796 11629827 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01007586001 11622796 11629827 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01007586001 11622796 11629827 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01007586001 11622796 11629827 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01007586001 11622796 11629827 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01007586001 11622796 11629827 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01032992001 24938396 24942992 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0030173 integral to Golgi membrane Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the Golgi complex membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Catalysis of the formation of sialylglycoconjugates via transfer of the sialic acid group from CMP to one of several glycoconjugate acceptors. IEA GO:0008373 sialyltransferase activity GSVIVG01018458001 14790052 14791748 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01018458001 14790052 14791748 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01018458001 14790052 14791748 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01018458001 14790052 14791748 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021265001 3196987 3199699 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01021265001 3196987 3199699 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017882001 4284970 4290269 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01004256001 37740961 37741499 GSVIVG01017175001 5011749 5013430 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01017175001 5011749 5013430 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025657001 13224257 13239040 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01013400001 696907 703692 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01013400001 696907 703692 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01013400001 696907 703692 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01013400001 696907 703692 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01013400001 696907 703692 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01013400001 696907 703692 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01013400001 696907 703692 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01013400001 696907 703692 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01013400001 696907 703692 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01013400001 696907 703692 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01013400001 696907 703692 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01013400001 696907 703692 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01013400001 696907 703692 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01013400001 696907 703692 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01013400001 696907 703692 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01013400001 696907 703692 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01013400001 696907 703692 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01013400001 696907 703692 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01013400001 696907 703692 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01013400001 696907 703692 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01013400001 696907 703692 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01013400001 696907 703692 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01013400001 696907 703692 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01013400001 696907 703692 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01013400001 696907 703692 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01013400001 696907 703692 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01013400001 696907 703692 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01013400001 696907 703692 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01013400001 696907 703692 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01013400001 696907 703692 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01013400001 696907 703692 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01013400001 696907 703692 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01013400001 696907 703692 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01013400001 696907 703692 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01013400001 696907 703692 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01013400001 696907 703692 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01013400001 696907 703692 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01013400001 696907 703692 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01013400001 696907 703692 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01013400001 696907 703692 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01013400001 696907 703692 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01013400001 696907 703692 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01013400001 696907 703692 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01013400001 696907 703692 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01013400001 696907 703692 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01013400001 696907 703692 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01013400001 696907 703692 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01013400001 696907 703692 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01013400001 696907 703692 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01013400001 696907 703692 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01013400001 696907 703692 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01013400001 696907 703692 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01013400001 696907 703692 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01013400001 696907 703692 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01013400001 696907 703692 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01013400001 696907 703692 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01013400001 696907 703692 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01013400001 696907 703692 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01013400001 696907 703692 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01013400001 696907 703692 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01013400001 696907 703692 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01013400001 696907 703692 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01013400001 696907 703692 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01017895001 4456371 4457678 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01020405001 19970563 19972299 GSVIVG01023730001 10231611 10231907 GSVIVG01009178001 5807852 5821053 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01009178001 5807852 5821053 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015292001 2446664 2449892 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01015292001 2446664 2449892 GO:0031123 RNA 3'-end processing Any process involved in forming the mature 3' end of an RNA molecule. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01015292001 2446664 2449892 GO:0043631 RNA polyadenylation The enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01015292001 2446664 2449892 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the template-independent extension of the 3'- end of an RNA or DNA strand by addition of one adenosine molecule at a time. Cannot initiate a chain 'de novo'. The primer, depending on the source of the enzyme, may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group. IEA GO:0004652 polynucleotide adenylyltransferase activity GSVIVG01015292001 2446664 2449892 GO:0031123 RNA 3'-end processing Any process involved in forming the mature 3' end of an RNA molecule. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the template-independent extension of the 3'- end of an RNA or DNA strand by addition of one adenosine molecule at a time. Cannot initiate a chain 'de novo'. The primer, depending on the source of the enzyme, may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group. IEA GO:0004652 polynucleotide adenylyltransferase activity GSVIVG01015292001 2446664 2449892 GO:0043631 RNA polyadenylation The enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the template-independent extension of the 3'- end of an RNA or DNA strand by addition of one adenosine molecule at a time. Cannot initiate a chain 'de novo'. The primer, depending on the source of the enzyme, may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group. IEA GO:0004652 polynucleotide adenylyltransferase activity GSVIVG01015292001 2446664 2449892 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the transfer of a nucleotidyl group to a reactant. IEA GO:0016779 nucleotidyltransferase activity GSVIVG01015292001 2446664 2449892 GO:0031123 RNA 3'-end processing Any process involved in forming the mature 3' end of an RNA molecule. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the transfer of a nucleotidyl group to a reactant. IEA GO:0016779 nucleotidyltransferase activity GSVIVG01015292001 2446664 2449892 GO:0043631 RNA polyadenylation The enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the transfer of a nucleotidyl group to a reactant. IEA GO:0016779 nucleotidyltransferase activity GSVIVG01001413001 18858920 18864380 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001413001 18858920 18864380 Catalysis of the elimination of H2S or substituted H2S. IEA GO:0016846 carbon-sulfur lyase activity GSVIVG01001413001 18858920 18864380 Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01017046001 3749844 3753841 The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01024686001 7756433 7765351 GSVIVG01020727001 2632948 2645749 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01020727001 2632948 2645749 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01020727001 2632948 2645749 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005945 6-phosphofructokinase complex A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01020727001 2632948 2645749 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0015934 large ribosomal subunit The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01020727001 2632948 2645749 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01020727001 2632948 2645749 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01020727001 2632948 2645749 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005945 6-phosphofructokinase complex A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01020727001 2632948 2645749 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0015934 large ribosomal subunit The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01020727001 2632948 2645749 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01020727001 2632948 2645749 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01020727001 2632948 2645749 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005945 6-phosphofructokinase complex A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01020727001 2632948 2645749 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015934 large ribosomal subunit The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01020727001 2632948 2645749 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01020727001 2632948 2645749 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01020727001 2632948 2645749 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005945 6-phosphofructokinase complex A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01020727001 2632948 2645749 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0015934 large ribosomal subunit The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01020727001 2632948 2645749 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01020727001 2632948 2645749 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01020727001 2632948 2645749 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005945 6-phosphofructokinase complex A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01020727001 2632948 2645749 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0015934 large ribosomal subunit The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01020727001 2632948 2645749 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01020727001 2632948 2645749 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01020727001 2632948 2645749 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005945 6-phosphofructokinase complex A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01020727001 2632948 2645749 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015934 large ribosomal subunit The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01020727001 2632948 2645749 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate. IEA GO:0003872 6-phosphofructokinase activity GSVIVG01020727001 2632948 2645749 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Catalysis of the reaction: ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate. IEA GO:0003872 6-phosphofructokinase activity GSVIVG01020727001 2632948 2645749 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005945 6-phosphofructokinase complex A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known. IEA Catalysis of the reaction: ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate. IEA GO:0003872 6-phosphofructokinase activity GSVIVG01020727001 2632948 2645749 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0015934 large ribosomal subunit The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). IEA Catalysis of the reaction: ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate. IEA GO:0003872 6-phosphofructokinase activity GSVIVG01020727001 2632948 2645749 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate. IEA GO:0003872 6-phosphofructokinase activity GSVIVG01020727001 2632948 2645749 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Catalysis of the reaction: ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate. IEA GO:0003872 6-phosphofructokinase activity GSVIVG01020727001 2632948 2645749 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005945 6-phosphofructokinase complex A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known. IEA Catalysis of the reaction: ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate. IEA GO:0003872 6-phosphofructokinase activity GSVIVG01020727001 2632948 2645749 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0015934 large ribosomal subunit The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). IEA Catalysis of the reaction: ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate. IEA GO:0003872 6-phosphofructokinase activity GSVIVG01020727001 2632948 2645749 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate. IEA GO:0003872 6-phosphofructokinase activity GSVIVG01020727001 2632948 2645749 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Catalysis of the reaction: ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate. IEA GO:0003872 6-phosphofructokinase activity GSVIVG01020727001 2632948 2645749 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005945 6-phosphofructokinase complex A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known. IEA Catalysis of the reaction: ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate. IEA GO:0003872 6-phosphofructokinase activity GSVIVG01020727001 2632948 2645749 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015934 large ribosomal subunit The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). IEA Catalysis of the reaction: ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate. IEA GO:0003872 6-phosphofructokinase activity GSVIVG01012876001 6448350 6450257 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01012876001 6448350 6450257 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01007968001 7072740 7094410 GSVIVG01027567001 15513258 15513691 GSVIVG01030982001 20241923 20242552 GO:0006869 lipid transport The directed movement of lipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GSVIVG01002066001 1300006 1301714 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01002066001 1300006 1301714 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01002066001 1300006 1301714 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01012403001 512570 514649 GSVIVG01022535001 4494544 4494990 GSVIVG01027164001 17315186 17317973 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027164001 17315186 17317973 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027164001 17315186 17317973 GO:0008283 cell proliferation The multiplication or reproduction of cells, resulting in the expansion of a cell population. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027164001 17315186 17317973 GO:0008283 cell proliferation The multiplication or reproduction of cells, resulting in the expansion of a cell population. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027164001 17315186 17317973 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with importin-alpha to mediate its transfer through the nuclear pore to the cytoplasm. IEA GO:0008262 importin-alpha export receptor activity GSVIVG01027164001 17315186 17317973 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with importin-alpha to mediate its transfer through the nuclear pore to the cytoplasm. IEA GO:0008262 importin-alpha export receptor activity GSVIVG01027164001 17315186 17317973 GO:0008283 cell proliferation The multiplication or reproduction of cells, resulting in the expansion of a cell population. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with importin-alpha to mediate its transfer through the nuclear pore to the cytoplasm. IEA GO:0008262 importin-alpha export receptor activity GSVIVG01027164001 17315186 17317973 GO:0008283 cell proliferation The multiplication or reproduction of cells, resulting in the expansion of a cell population. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with importin-alpha to mediate its transfer through the nuclear pore to the cytoplasm. IEA GO:0008262 importin-alpha export receptor activity GSVIVG01027164001 17315186 17317973 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01027164001 17315186 17317973 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01027164001 17315186 17317973 GO:0008283 cell proliferation The multiplication or reproduction of cells, resulting in the expansion of a cell population. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01027164001 17315186 17317973 GO:0008283 cell proliferation The multiplication or reproduction of cells, resulting in the expansion of a cell population. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01025983001 26339440 26341510 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01025983001 26339440 26341510 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01025983001 26339440 26341510 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01025983001 26339440 26341510 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01005233001 19629757 19632068 GO:0016459 myosin complex A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. IEA Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate. IEA GO:0003774 motor activity GSVIVG01005233001 19629757 19632068 GO:0016459 myosin complex A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031758001 4095047 4095827 GSVIVG01024081001 1283245 1285209 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01029215001 18451729 18452626 The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01034221001 12984241 12985646 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01026682001 4712047 4714860 GSVIVG01008554001 914171 918824 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008554001 914171 918824 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01022230001 17698349 17700892 GSVIVG01015275001 2331688 2335681 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. IEA GO:0004725 protein tyrosine phosphatase activity GSVIVG01015275001 2331688 2335681 GO:0016311 dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. IEA Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. IEA GO:0004725 protein tyrosine phosphatase activity GSVIVG01015275001 2331688 2335681 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA Catalysis of the reaction: protein serine/threonine/tyrosine phosphate + H2O = protein serine/threonine/tyrosine + phosphate. IEA GO:0008138 protein tyrosine/serine/threonine phosphatase activity GSVIVG01015275001 2331688 2335681 GO:0016311 dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. IEA Catalysis of the reaction: protein serine/threonine/tyrosine phosphate + H2O = protein serine/threonine/tyrosine + phosphate. IEA GO:0008138 protein tyrosine/serine/threonine phosphatase activity GSVIVG01015275001 2331688 2335681 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. IEA GO:0016791 phosphatase activity GSVIVG01015275001 2331688 2335681 GO:0016311 dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. IEA Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. IEA GO:0016791 phosphatase activity GSVIVG01024313001 770349 775027 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01024313001 770349 775027 GO:0006419 alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01024313001 770349 775027 GO:0043039 tRNA aminoacylation The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01024313001 770349 775027 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01024313001 770349 775027 GO:0006419 alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01024313001 770349 775027 GO:0043039 tRNA aminoacylation The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01024313001 770349 775027 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala). IEA GO:0004813 alanine-tRNA ligase activity GSVIVG01024313001 770349 775027 GO:0006419 alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala). IEA GO:0004813 alanine-tRNA ligase activity GSVIVG01024313001 770349 775027 GO:0043039 tRNA aminoacylation The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala). IEA GO:0004813 alanine-tRNA ligase activity GSVIVG01024313001 770349 775027 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024313001 770349 775027 GO:0006419 alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024313001 770349 775027 GO:0043039 tRNA aminoacylation The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024313001 770349 775027 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances via a carbon-oxygen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate, to form aminoacyl-tRNA or a related compound. IEA GO:0016876 ligase activity, forming aminoacyl-tRNA and related compounds GSVIVG01024313001 770349 775027 GO:0006419 alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances via a carbon-oxygen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate, to form aminoacyl-tRNA or a related compound. IEA GO:0016876 ligase activity, forming aminoacyl-tRNA and related compounds GSVIVG01024313001 770349 775027 GO:0043039 tRNA aminoacylation The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances via a carbon-oxygen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate, to form aminoacyl-tRNA or a related compound. IEA GO:0016876 ligase activity, forming aminoacyl-tRNA and related compounds GSVIVG01006786001 28492968 28495601 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01006786001 28492968 28495601 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01006786001 28492968 28495601 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01006786001 28492968 28495601 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01006786001 28492968 28495601 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01006786001 28492968 28495601 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01006786001 28492968 28495601 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01006786001 28492968 28495601 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01006786001 28492968 28495601 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006786001 28492968 28495601 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032722001 1257916 1262866 GSVIVG01015173001 1559038 1562781 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01015173001 1559038 1562781 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01015173001 1559038 1562781 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01015173001 1559038 1562781 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015173001 1559038 1562781 Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01015173001 1559038 1562781 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01022014001 4293875 4298211 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01027058001 18268447 18273292 GSVIVG01034919001 124089 125174 GSVIVG01013643001 2059061 2066119 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01013643001 2059061 2066119 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01013643001 2059061 2066119 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01013643001 2059061 2066119 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01013643001 2059061 2066119 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01013643001 2059061 2066119 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01013643001 2059061 2066119 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01013643001 2059061 2066119 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01013643001 2059061 2066119 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01013643001 2059061 2066119 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01013643001 2059061 2066119 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01013643001 2059061 2066119 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01013643001 2059061 2066119 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01013643001 2059061 2066119 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01013643001 2059061 2066119 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01013643001 2059061 2066119 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01013643001 2059061 2066119 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the movement of phospholipids from one membrane face to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP. IEA GO:0004012 phospholipid-translocating ATPase activity GSVIVG01013643001 2059061 2066119 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the movement of phospholipids from one membrane face to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP. IEA GO:0004012 phospholipid-translocating ATPase activity GSVIVG01013643001 2059061 2066119 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the movement of phospholipids from one membrane face to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP. IEA GO:0004012 phospholipid-translocating ATPase activity GSVIVG01013643001 2059061 2066119 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the movement of phospholipids from one membrane face to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP. IEA GO:0004012 phospholipid-translocating ATPase activity GSVIVG01013643001 2059061 2066119 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the movement of phospholipids from one membrane face to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP. IEA GO:0004012 phospholipid-translocating ATPase activity GSVIVG01013643001 2059061 2066119 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the movement of phospholipids from one membrane face to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP. IEA GO:0004012 phospholipid-translocating ATPase activity GSVIVG01013643001 2059061 2066119 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the movement of phospholipids from one membrane face to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP. IEA GO:0004012 phospholipid-translocating ATPase activity GSVIVG01013643001 2059061 2066119 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the movement of phospholipids from one membrane face to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP. IEA GO:0004012 phospholipid-translocating ATPase activity GSVIVG01013643001 2059061 2066119 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01013643001 2059061 2066119 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01013643001 2059061 2066119 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01013643001 2059061 2066119 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01013643001 2059061 2066119 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01013643001 2059061 2066119 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01013643001 2059061 2066119 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01013643001 2059061 2066119 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01013643001 2059061 2066119 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013643001 2059061 2066119 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013643001 2059061 2066119 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013643001 2059061 2066119 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013643001 2059061 2066119 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013643001 2059061 2066119 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013643001 2059061 2066119 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013643001 2059061 2066119 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013643001 2059061 2066119 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01013643001 2059061 2066119 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01013643001 2059061 2066119 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01013643001 2059061 2066119 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01013643001 2059061 2066119 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01013643001 2059061 2066119 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01013643001 2059061 2066119 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01013643001 2059061 2066119 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01013643001 2059061 2066119 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01013643001 2059061 2066119 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01013643001 2059061 2066119 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01013643001 2059061 2066119 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01013643001 2059061 2066119 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01013643001 2059061 2066119 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01013643001 2059061 2066119 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01013643001 2059061 2066119 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01020030001 11323607 11332468 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020030001 11323607 11332468 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020030001 11323607 11332468 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020030001 11323607 11332468 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01020030001 11323607 11332468 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01020030001 11323607 11332468 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01020030001 11323607 11332468 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01020030001 11323607 11332468 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01020030001 11323607 11332468 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01020030001 11323607 11332468 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01020030001 11323607 11332468 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01020030001 11323607 11332468 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01006778001 230922 232464 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01006778001 230922 232464 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01006778001 230922 232464 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01006778001 230922 232464 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01006778001 230922 232464 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01006778001 230922 232464 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01006778001 230922 232464 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006778001 230922 232464 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007809001 8799669 8806712 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01007809001 8799669 8806712 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01018951001 18421693 18423027 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01018951001 18421693 18423027 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01018951001 18421693 18423027 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01025680001 12990133 12995157 GSVIVG01032486001 27801696 27810168 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021351001 4358782 4360023 GSVIVG01035773001 4185433 4190152 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. IEA GO:0008080 N-acetyltransferase activity GSVIVG01007765001 9272857 9280462 GSVIVG01036230001 8586440 8587693 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01036230001 8586440 8587693 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025347001 1654626 1670187 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01025347001 1654626 1670187 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01025347001 1654626 1670187 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01025347001 1654626 1670187 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025347001 1654626 1670187 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01022730001 15723380 15724182 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01022730001 15723380 15724182 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035432001 1230119 1237687 GSVIVG01016492001 3437296 3441188 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016492001 3437296 3441188 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016492001 3437296 3441188 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016492001 3437296 3441188 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01016492001 3437296 3441188 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01016492001 3437296 3441188 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01016492001 3437296 3441188 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016492001 3437296 3441188 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016492001 3437296 3441188 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016492001 3437296 3441188 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01016492001 3437296 3441188 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01016492001 3437296 3441188 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01016492001 3437296 3441188 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016492001 3437296 3441188 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016492001 3437296 3441188 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01034455001 21049252 21050534 Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate. IEA GO:0008146 sulfotransferase activity GSVIVG01023744001 10541024 10543465 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01023744001 10541024 10543465 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01020738001 2459824 2461558 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01020738001 2459824 2461558 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01020738001 2459824 2461558 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01020738001 2459824 2461558 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01034173001 14635316 14639812 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01034173001 14635316 14639812 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01034173001 14635316 14639812 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01034173001 14635316 14639812 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01034173001 14635316 14639812 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034173001 14635316 14639812 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017345001 6967053 6976723 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01017345001 6967053 6976723 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01017345001 6967053 6976723 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01017345001 6967053 6976723 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01017345001 6967053 6976723 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022903001 18166528 18177892 GSVIVG01023317001 19773845 19774192 GSVIVG01035354001 700692 706374 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01034133001 14923383 14952021 GO:0006364 rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. IEA GO:0032040 small-subunit processome A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins. IEA GSVIVG01019821001 3631707 3639546 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01019821001 3631707 3639546 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01019821001 3631707 3639546 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01019821001 3631707 3639546 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01019821001 3631707 3639546 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01019821001 3631707 3639546 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01019821001 3631707 3639546 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01019821001 3631707 3639546 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01019821001 3631707 3639546 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01019821001 3631707 3639546 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01019821001 3631707 3639546 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01019821001 3631707 3639546 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01019821001 3631707 3639546 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019821001 3631707 3639546 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019821001 3631707 3639546 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035523001 2008749 2010011 GSVIVG01028731001 19314108 19317425 GSVIVG01003474001 10586639 10592068 GO:0009416 response to light stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01003474001 10586639 10592068 GO:0009416 response to light stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01008782001 1982673 1985445 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01008782001 1982673 1985445 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01002901001 37118455 37119079 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01002901001 37118455 37119079 GO:0019295 coenzyme M biosynthetic process The chemical reactions and pathways resulting in the formation of coenzyme M (2-thioethansulfonate), a coenzyme involved in the utilization of methane by methanogenic prokaryotes. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001101001 22640306 22644443 Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01001101001 22640306 22644443 Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01001101001 22640306 22644443 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01001101001 22640306 22644443 Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01013500001 1937452 1943565 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01013500001 1937452 1943565 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01016706001 502887 509976 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016706001 502887 509976 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016706001 502887 509976 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016706001 502887 509976 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016706001 502887 509976 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01016706001 502887 509976 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01016706001 502887 509976 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01016706001 502887 509976 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01016706001 502887 509976 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01016706001 502887 509976 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01024129001 888666 888953 GSVIVG01034595001 14751514 14755468 Catalysis of the removal of a phosphate group from phosphorylated myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol. IEA GO:0004437 inositol or phosphatidylinositol phosphatase activity GSVIVG01031847001 4857382 4858281 GSVIVG01032178001 21799879 21802658 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032178001 21799879 21802658 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032178001 21799879 21802658 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032178001 21799879 21802658 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032178001 21799879 21802658 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01032178001 21799879 21802658 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01032178001 21799879 21802658 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01032178001 21799879 21802658 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01007745001 9661925 9664617 GO:0015976 carbon utilization A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbon sources and then activates genes to scavenge the last traces of the primary carbon source and to transport and metabolize alternative carbon sources such as carbon dioxide or carbonic acid. The utilization process begins when the cell or organism detects carbon levels, includes the activation of genes whose products detect, transport or metabolize carbon-containing substances, and ends when carbon is incorporated into the cell or organism's metabolism. IEA Catalysis of the reaction: H2CO3 = CO2 + H2O. IEA GO:0004089 carbonate dehydratase activity GSVIVG01007745001 9661925 9664617 GO:0015976 carbon utilization A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbon sources and then activates genes to scavenge the last traces of the primary carbon source and to transport and metabolize alternative carbon sources such as carbon dioxide or carbonic acid. The utilization process begins when the cell or organism detects carbon levels, includes the activation of genes whose products detect, transport or metabolize carbon-containing substances, and ends when carbon is incorporated into the cell or organism's metabolism. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01024687001 7749760 7750762 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01020935001 16908332 16927779 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01027119001 17668981 17672635 GSVIVG01000383001 390224 405802 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. IEA GO:0008080 N-acetyltransferase activity GSVIVG01007071001 30037610 30040310 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01007071001 30037610 30040310 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01007071001 30037610 30040310 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01007071001 30037610 30040310 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01013189001 6938299 6951193 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GSVIVG01033515001 20079672 20081833 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01016621001 2375563 2377850 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar. IEA GO:0008375 acetylglucosaminyltransferase activity GSVIVG01000249001 20523162 20529902 GSVIVG01035493001 1745548 1753263 GSVIVG01018019001 5513730 5518194 Catalysis of the reaction: S-adenosyl-L-methionine + L-homocysteine = S-adenosyl-L-homocysteine + L-methionine. IEA GO:0008898 homocysteine S-methyltransferase activity GSVIVG01035521001 1980740 1983242 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01021418001 5094263 5117202 GSVIVG01032480001 27781260 27782988 GSVIVG01016184001 6924828 6931568 GSVIVG01020747001 2385535 2386936 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA GSVIVG01026820001 20229413 20231234 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026820001 20229413 20231234 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01036346001 4021830 4024937 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01024931001 5942791 5944119 GSVIVG01036097001 20725899 20726525 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with manganese (Mn) ions. IEA GO:0030145 manganese ion binding GSVIVG01036097001 20725899 20726525 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Functions in the storage of nutritious substrates. IEA GO:0045735 nutrient reservoir activity GSVIVG01007144001 30449202 30462178 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01007144001 30449202 30462178 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01007144001 30449202 30462178 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01007144001 30449202 30462178 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01007144001 30449202 30462178 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007144001 30449202 30462178 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007144001 30449202 30462178 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01007144001 30449202 30462178 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01017333001 6821815 6824560 GSVIVG01020594001 3959773 3963890 GO:0006519 cellular amino acid and derivative metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01020594001 3959773 3963890 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01020594001 3959773 3963890 GO:0006519 cellular amino acid and derivative metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells. IEA Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. IEA GO:0008483 transaminase activity GSVIVG01020594001 3959773 3963890 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. IEA GO:0008483 transaminase activity GSVIVG01020594001 3959773 3963890 GO:0006519 cellular amino acid and derivative metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells. IEA Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). IEA GO:0016769 transferase activity, transferring nitrogenous groups GSVIVG01020594001 3959773 3963890 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). IEA GO:0016769 transferase activity, transferring nitrogenous groups GSVIVG01020594001 3959773 3963890 GO:0006519 cellular amino acid and derivative metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells. IEA Catalysis of the reaction: S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + methylthioadenosine. IEA GO:0016847 1-aminocyclopropane-1-carboxylate synthase activity GSVIVG01020594001 3959773 3963890 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + methylthioadenosine. IEA GO:0016847 1-aminocyclopropane-1-carboxylate synthase activity GSVIVG01020594001 3959773 3963890 GO:0006519 cellular amino acid and derivative metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01020594001 3959773 3963890 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01002236001 33565472 33565863 GSVIVG01035812001 4560587 4563264 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals. IEA GO:0008519 ammonium transmembrane transporter activity GSVIVG01035812001 4560587 4563264 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals. IEA GO:0008519 ammonium transmembrane transporter activity GSVIVG01019575001 1699245 1702798 GSVIVG01016610001 2445004 2450927 GSVIVG01030138001 10151320 10162488 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01030138001 10151320 10162488 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01030138001 10151320 10162488 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01030138001 10151320 10162488 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01030286001 9468385 9469362 GSVIVG01038605001 21544160 21548340 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GSVIVG01011426001 29563964 29564402 GSVIVG01013747001 7972480 7972665 GSVIVG01014233001 1739220 1741641 GSVIVG01003882001 13120422 13121469 GSVIVG01005148001 18545112 18559495 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GSVIVG01020170001 9457364 9477097 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01020170001 9457364 9477097 Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters. IEA GO:0004523 ribonuclease H activity GSVIVG01018986001 18053845 18064423 GSVIVG01007898001 7777018 7784744 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01025908001 27337565 27339270 GSVIVG01020997001 15668462 15682244 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020997001 15668462 15682244 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01021977001 4811181 4820670 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021977001 4811181 4820670 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021977001 4811181 4820670 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: 3-dehydroquinate = 3-dehydroshikimate + H2O. IEA GO:0003855 3-dehydroquinate dehydratase activity GSVIVG01021977001 4811181 4820670 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: 3-dehydroquinate = 3-dehydroshikimate + H2O. IEA GO:0003855 3-dehydroquinate dehydratase activity GSVIVG01021977001 4811181 4820670 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: shikimate + NADP+ = 5-dehydroshikimate + NADPH + H+. IEA GO:0004764 shikimate 5-dehydrogenase activity GSVIVG01021977001 4811181 4820670 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: shikimate + NADP+ = 5-dehydroshikimate + NADPH + H+. IEA GO:0004764 shikimate 5-dehydrogenase activity GSVIVG01021977001 4811181 4820670 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01021977001 4811181 4820670 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01021977001 4811181 4820670 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01021977001 4811181 4820670 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01019025001 17612788 17614321 GO:0008299 isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. IEA GSVIVG01020826001 1496335 1500701 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01031622001 19079704 19088500 GSVIVG01001056001 7132629 7132904 GSVIVG01017721001 2902757 2906309 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01017721001 2902757 2906309 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01024233001 98352 101803 GSVIVG01026542001 22059055 22060769 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01026542001 22059055 22060769 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024267001 401533 403618 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01024267001 401533 403618 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01024267001 401533 403618 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01024267001 401533 403618 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01017644001 2340665 2343191 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01017644001 2340665 2343191 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01017644001 2340665 2343191 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01017644001 2340665 2343191 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01017644001 2340665 2343191 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01017644001 2340665 2343191 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01006400001 25624425 25629624 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01012052001 1774706 1776157 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01012052001 1774706 1776157 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01019714001 2655931 2659710 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01008931001 3536802 3542239 GO:0046488 phosphatidylinositol metabolic process The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008931001 3536802 3542239 GO:0046488 phosphatidylinositol metabolic process The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. IEA Catalysis of the phosphorylation of phosphatidylinositol phosphate to produce phosphatidylinositol bisphosphate. IEA GO:0016307 phosphatidylinositol phosphate kinase activity GSVIVG01008931001 3536802 3542239 GO:0046488 phosphatidylinositol metabolic process The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. IEA Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate. IEA GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity GSVIVG01017286001 6372872 6374662 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01017286001 6372872 6374662 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01017286001 6372872 6374662 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01017286001 6372872 6374662 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01027525001 15986360 15988423 GSVIVG01000921001 21920560 21924350 GSVIVG01003708001 15155531 15164220 GSVIVG01028363001 6631551 6640386 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01028363001 6631551 6640386 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01028363001 6631551 6640386 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01028363001 6631551 6640386 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033537001 19878173 19880417 GSVIVG01011850001 3595152 3609449 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01011850001 3595152 3609449 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01011850001 3595152 3609449 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01011850001 3595152 3609449 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01011850001 3595152 3609449 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029138001 19269887 19270275 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01029138001 19269887 19270275 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01029138001 19269887 19270275 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01029138001 19269887 19270275 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01017239001 5799933 5806574 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the repair of a photoproduct resulting from ultraviolet irradiation of two adjacent pyrimidine residues in DNA. IEA GO:0003913 DNA photolyase activity GSVIVG01026090001 24686322 24706873 GSVIVG01016552001 2865915 2866838 GSVIVG01016753001 910682 912319 GSVIVG01025175001 3700332 3704868 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025175001 3700332 3704868 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01020414001 19846206 19847357 GSVIVG01026156001 13093547 13095293 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01026156001 13093547 13095293 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01024922001 6012398 6014634 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01024922001 6012398 6014634 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01011480001 29953927 29955200 GSVIVG01032112001 22569927 22575687 GSVIVG01006942001 29188583 29194559 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01006942001 29188583 29194559 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01006942001 29188583 29194559 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01006942001 29188583 29194559 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01006942001 29188583 29194559 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003572001 14743074 14755623 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01003572001 14743074 14755623 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01003572001 14743074 14755623 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003572001 14743074 14755623 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003572001 14743074 14755623 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01003572001 14743074 14755623 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01014774001 9497778 9504060 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01014774001 9497778 9504060 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01007065001 29976413 29982608 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01024969001 5617607 5622668 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01006258001 24132518 24139529 GSVIVG01021241001 2908195 2910705 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01031698001 20312697 20315158 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031698001 20312697 20315158 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01031698001 20312697 20315158 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01019446001 734377 743551 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01019446001 734377 743551 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01019446001 734377 743551 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01019446001 734377 743551 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01019446001 734377 743551 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01019446001 734377 743551 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01019446001 734377 743551 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003036001 37576766 37578161 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01003036001 37576766 37578161 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031163001 1583768 1590579 GSVIVG01038162001 24005036 24006153 GO:0006631 fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01038162001 24005036 24006153 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01038162001 24005036 24006153 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01038162001 24005036 24006153 GO:0006631 fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. IEA Catalysis of the reaction: stearoyl-[acyl-carrier protein] + reduced acceptor + O2 = oleoyl-[acyl-carrier protein] + acceptor + H2O. The enzyme requires ferredoxin. IEA GO:0045300 acyl-[acyl-carrier-protein] desaturase activity GSVIVG01038162001 24005036 24006153 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Catalysis of the reaction: stearoyl-[acyl-carrier protein] + reduced acceptor + O2 = oleoyl-[acyl-carrier protein] + acceptor + H2O. The enzyme requires ferredoxin. IEA GO:0045300 acyl-[acyl-carrier-protein] desaturase activity GSVIVG01038162001 24005036 24006153 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: stearoyl-[acyl-carrier protein] + reduced acceptor + O2 = oleoyl-[acyl-carrier protein] + acceptor + H2O. The enzyme requires ferredoxin. IEA GO:0045300 acyl-[acyl-carrier-protein] desaturase activity GSVIVG01038162001 24005036 24006153 GO:0006631 fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01038162001 24005036 24006153 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01038162001 24005036 24006153 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01008968001 3924182 3930364 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008968001 3924182 3930364 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). IEA GO:0016769 transferase activity, transferring nitrogenous groups GSVIVG01008968001 3924182 3930364 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01014933001 12246638 12249791 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014933001 12246638 12249791 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014933001 12246638 12249791 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014933001 12246638 12249791 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014933001 12246638 12249791 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014933001 12246638 12249791 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014933001 12246638 12249791 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014933001 12246638 12249791 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014933001 12246638 12249791 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01014933001 12246638 12249791 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01036801001 22379272 22383673 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01036801001 22379272 22383673 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01036801001 22379272 22383673 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036801001 22379272 22383673 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036801001 22379272 22383673 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01036801001 22379272 22383673 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01036801001 22379272 22383673 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01036801001 22379272 22383673 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01036801001 22379272 22383673 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01036801001 22379272 22383673 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01032686001 1550154 1552089 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01032686001 1550154 1552089 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01032686001 1550154 1552089 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01032686001 1550154 1552089 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01032686001 1550154 1552089 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01032686001 1550154 1552089 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01032784001 801393 802715 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01031187001 1376229 1377507 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01031187001 1376229 1377507 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01031187001 1376229 1377507 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01031187001 1376229 1377507 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01031187001 1376229 1377507 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01031187001 1376229 1377507 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01031187001 1376229 1377507 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01031187001 1376229 1377507 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01003673001 12000798 12002613 GSVIVG01002409001 34618858 34620283 GSVIVG01024194001 452476 454201 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01024194001 452476 454201 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01024194001 452476 454201 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01012154001 989103 993721 GSVIVG01012443001 837655 840369 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012443001 837655 840369 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024443001 2627105 2627684 GSVIVG01018873001 19065537 19067983 GSVIVG01018747001 20243123 20247788 GSVIVG01006721001 1242560 1244559 GSVIVG01001433001 20938716 20952481 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004185 serine-type carboxypeptidase activity GSVIVG01013722001 8209578 8210725 GSVIVG01037909001 6415508 6420526 GSVIVG01035921001 5879265 5888462 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035921001 5879265 5888462 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035921001 5879265 5888462 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01035921001 5879265 5888462 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01035921001 5879265 5888462 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01035921001 5879265 5888462 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01031574001 18363004 18370088 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01031574001 18363004 18370088 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033180 proton-transporting V-type ATPase, V1 domain A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01031574001 18363004 18370088 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01031574001 18363004 18370088 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033180 proton-transporting V-type ATPase, V1 domain A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01031423001 18771503 18786618 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01004409001 38434334 38436345 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01028430001 7450247 7454376 GSVIVG01011595001 6118791 6121849 GSVIVG01013965001 8000259 8010966 GSVIVG01038631001 21339142 21340093 GSVIVG01018356001 10569089 10574605 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01018356001 10569089 10574605 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01018356001 10569089 10574605 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015934 large ribosomal subunit The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01026842001 20042160 20042639 GSVIVG01010981001 2451636 2452238 GSVIVG01021092001 1397937 1399285 GSVIVG01035413001 1104425 1110865 GSVIVG01011888001 3271099 3277987 GSVIVG01014046001 9955226 9957621 GSVIVG01001390001 24163154 24163713 GSVIVG01036739001 23135393 23145621 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01024932001 5938487 5942544 GSVIVG01014620001 5759972 5763303 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01014782001 9657887 9658472 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01014782001 9657887 9658472 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01027209001 18253669 18256103 GSVIVG01013628001 1923473 1946502 GSVIVG01018306001 11384913 11385750 GSVIVG01029356001 15154115 15154728 GSVIVG01014107001 473474 478208 GSVIVG01032705001 1367848 1370392 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA Catalysis of the reaction: protein serine/threonine/tyrosine phosphate + H2O = protein serine/threonine/tyrosine + phosphate. IEA GO:0008138 protein tyrosine/serine/threonine phosphatase activity GSVIVG01032705001 1367848 1370392 GO:0016311 dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. IEA Catalysis of the reaction: protein serine/threonine/tyrosine phosphate + H2O = protein serine/threonine/tyrosine + phosphate. IEA GO:0008138 protein tyrosine/serine/threonine phosphatase activity GSVIVG01032705001 1367848 1370392 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. IEA GO:0016791 phosphatase activity GSVIVG01032705001 1367848 1370392 GO:0016311 dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. IEA Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. IEA GO:0016791 phosphatase activity GSVIVG01004272001 37895442 37900448 GO:0015946 methanol oxidation The chemical reactions and pathways resulting in the conversion of methanol to methyl-Coenzyme M. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01004272001 37895442 37900448 GO:0015946 methanol oxidation The chemical reactions and pathways resulting in the conversion of methanol to methyl-Coenzyme M. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01004272001 37895442 37900448 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01004272001 37895442 37900448 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01004272001 37895442 37900448 GO:0015946 methanol oxidation The chemical reactions and pathways resulting in the conversion of methanol to methyl-Coenzyme M. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01004272001 37895442 37900448 GO:0015946 methanol oxidation The chemical reactions and pathways resulting in the conversion of methanol to methyl-Coenzyme M. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01004272001 37895442 37900448 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01004272001 37895442 37900448 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01004272001 37895442 37900448 GO:0015946 methanol oxidation The chemical reactions and pathways resulting in the conversion of methanol to methyl-Coenzyme M. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01004272001 37895442 37900448 GO:0015946 methanol oxidation The chemical reactions and pathways resulting in the conversion of methanol to methyl-Coenzyme M. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01004272001 37895442 37900448 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01004272001 37895442 37900448 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01019834001 3737145 3744356 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01031935001 5548050 5553974 Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor). IEA GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups GSVIVG01030455001 5697061 5698503 GSVIVG01016069001 18312327 18321373 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016069001 18312327 18321373 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016069001 18312327 18321373 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016069001 18312327 18321373 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016069001 18312327 18321373 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016069001 18312327 18321373 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016069001 18312327 18321373 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01016069001 18312327 18321373 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01016069001 18312327 18321373 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01016069001 18312327 18321373 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016069001 18312327 18321373 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016069001 18312327 18321373 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01026434001 23647376 23649541 GSVIVG01001516001 5457917 5458363 GSVIVG01019854001 3852688 3856475 GSVIVG01035737001 3814571 3816956 GO:0032312 regulation of ARF GTPase activity Any process that modulates the activity of the GTPase ARF. IEA Increases the rate of GTP hydrolysis by the GTPase ARF. IEA GO:0008060 ARF GTPase activator activity GSVIVG01035737001 3814571 3816956 GO:0032312 regulation of ARF GTPase activity Any process that modulates the activity of the GTPase ARF. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01024683001 7774710 7777429 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01038627001 21361627 21365096 GSVIVG01034568001 19321736 19326281 GSVIVG01032672001 1617548 1622667 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01011882001 3329892 3332272 GO:0006308 DNA catabolic process The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01011882001 3329892 3332272 GO:0006308 DNA catabolic process The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. IEA GO:0004519 endonuclease activity GSVIVG01011882001 3329892 3332272 GO:0006308 DNA catabolic process The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01001889001 6823349 6824835 GSVIVG01028754001 19171398 19171505 GSVIVG01024416001 2283679 2293161 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01024416001 2283679 2293161 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01005305001 20434234 20435982 GO:0016481 negative regulation of transcription Any cellular process that stops, prevents or reduces the frequency, rate or extent of transcription. IEA Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0010181 FMN binding GSVIVG01005305001 20434234 20435982 GO:0016481 negative regulation of transcription Any cellular process that stops, prevents or reduces the frequency, rate or extent of transcription. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01005062001 17812127 17813178 GSVIVG01035505001 1863214 1868860 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0031227 intrinsic to endoplasmic reticulum membrane Located in the endoplasmic reticulum membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01035505001 1863214 1868860 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0031227 intrinsic to endoplasmic reticulum membrane Located in the endoplasmic reticulum membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01035505001 1863214 1868860 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0031227 intrinsic to endoplasmic reticulum membrane Located in the endoplasmic reticulum membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01026449001 23459594 23532718 GO:0002098 tRNA wobble uridine modification The process whereby a uridine in position 34 of a tRNA is post-transcriptionally modified. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01026449001 23459594 23532718 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01026449001 23459594 23532718 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01026449001 23459594 23532718 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01026449001 23459594 23532718 GO:0002098 tRNA wobble uridine modification The process whereby a uridine in position 34 of a tRNA is post-transcriptionally modified. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA A ligand-dependent receptor found in the nucleus of the cell. IEA GO:0004879 ligand-dependent nuclear receptor activity GSVIVG01026449001 23459594 23532718 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA A ligand-dependent receptor found in the nucleus of the cell. IEA GO:0004879 ligand-dependent nuclear receptor activity GSVIVG01026449001 23459594 23532718 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA A ligand-dependent receptor found in the nucleus of the cell. IEA GO:0004879 ligand-dependent nuclear receptor activity GSVIVG01026449001 23459594 23532718 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA A ligand-dependent receptor found in the nucleus of the cell. IEA GO:0004879 ligand-dependent nuclear receptor activity GSVIVG01026449001 23459594 23532718 GO:0002098 tRNA wobble uridine modification The process whereby a uridine in position 34 of a tRNA is post-transcriptionally modified. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01026449001 23459594 23532718 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01026449001 23459594 23532718 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01026449001 23459594 23532718 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01026449001 23459594 23532718 GO:0002098 tRNA wobble uridine modification The process whereby a uridine in position 34 of a tRNA is post-transcriptionally modified. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01026449001 23459594 23532718 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01026449001 23459594 23532718 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01026449001 23459594 23532718 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01018920001 18633898 18634656 GSVIVG01036390001 4551420 4560268 GSVIVG01018426001 9136180 9137208 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01018426001 9136180 9137208 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01018426001 9136180 9137208 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01018426001 9136180 9137208 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01036442001 21953629 21962746 GSVIVG01009437001 8350649 8352499 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0009424 bacterial-type flagellum hook The portion of the flagellum that connects the filament to the basal body. Examples of this component are found in bacteria. IEA Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate. IEA GO:0003774 motor activity GSVIVG01009437001 8350649 8352499 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate. IEA GO:0003774 motor activity GSVIVG01009437001 8350649 8352499 GO:0009296 flagellum assembly The assembly of a flagellum. In bacteria, this is a whiplike motility appendage present on the surface of some species; in eukaryotes, flagella are threadlike protoplasmic extensions used to propel flagellates and sperm. Flagella are composed of flagellin and have the same basic structure as cilia but are longer in proportion to the cell and present in much smaller numbers. IEA GO:0009424 bacterial-type flagellum hook The portion of the flagellum that connects the filament to the basal body. Examples of this component are found in bacteria. IEA Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate. IEA GO:0003774 motor activity GSVIVG01009437001 8350649 8352499 GO:0009296 flagellum assembly The assembly of a flagellum. In bacteria, this is a whiplike motility appendage present on the surface of some species; in eukaryotes, flagella are threadlike protoplasmic extensions used to propel flagellates and sperm. Flagella are composed of flagellin and have the same basic structure as cilia but are longer in proportion to the cell and present in much smaller numbers. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate. IEA GO:0003774 motor activity GSVIVG01008736001 1550512 1554616 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01008736001 1550512 1554616 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01008736001 1550512 1554616 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01019046001 17398366 17416188 GO:0016568 chromatin modification The alteration of DNA or protein in chromatin, which may result in changing the chromatin structure. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01019046001 17398366 17416188 GO:0016568 chromatin modification The alteration of DNA or protein in chromatin, which may result in changing the chromatin structure. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01019046001 17398366 17416188 GO:0016568 chromatin modification The alteration of DNA or protein in chromatin, which may result in changing the chromatin structure. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives. IEA GO:0018024 histone-lysine N-methyltransferase activity GSVIVG01019046001 17398366 17416188 GO:0016568 chromatin modification The alteration of DNA or protein in chromatin, which may result in changing the chromatin structure. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives. IEA GO:0018024 histone-lysine N-methyltransferase activity GSVIVG01035730001 3758056 3767914 GSVIVG01022390001 19567594 19574519 GSVIVG01007794001 8952004 8971372 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01007794001 8952004 8971372 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01007794001 8952004 8971372 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01007794001 8952004 8971372 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01007794001 8952004 8971372 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01007794001 8952004 8971372 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01018384001 9984817 9995095 GSVIVG01018867001 19107432 19110307 GSVIVG01036517001 22960480 22978010 GSVIVG01031320001 390997 395635 GSVIVG01019272001 2209436 2209624 GSVIVG01001396001 24201814 24203871 GSVIVG01034247001 13450469 13452476 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01034247001 13450469 13452476 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01034247001 13450469 13452476 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011187001 7943751 7957148 GO:0030494 bacteriochlorophyll biosynthetic process The chemical reactions and pathways resulting in the formation of a bacteriochlorophyll, any of the chlorophylls of photosynthetic bacteria. They differ structurally from the chlorophylls of higher plants. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor). IEA GO:0004659 prenyltransferase activity GSVIVG01011187001 7943751 7957148 GO:0030494 bacteriochlorophyll biosynthetic process The chemical reactions and pathways resulting in the formation of a bacteriochlorophyll, any of the chlorophylls of photosynthetic bacteria. They differ structurally from the chlorophylls of higher plants. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: chlorophyllide a + phytyl diphosphate = chlorophyll a + diphosphate. IEA GO:0043787 chlorophyll synthase activity GSVIVG01011514001 30220096 30253071 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028231001 4800193 4811282 GSVIVG01002888001 36997515 36997901 GSVIVG01029180001 18874056 18902406 GSVIVG01014648001 8205248 8211487 GSVIVG01001950001 15209739 15215428 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and carries out proton transport across a membrane. The proton-transporting domain (F0, V0, or A0) includes integral and peripheral membrane proteins. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01017931001 4799947 4802669 GSVIVG01011350001 28879551 28888389 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01011350001 28879551 28888389 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01031319001 397264 401578 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01031319001 397264 401578 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01031319001 397264 401578 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01031319001 397264 401578 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01031319001 397264 401578 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01031319001 397264 401578 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01031319001 397264 401578 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031319001 397264 401578 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031319001 397264 401578 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031319001 397264 401578 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01031319001 397264 401578 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01031319001 397264 401578 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01022088001 16492074 16494473 GSVIVG01006516001 42696240 42698176 GSVIVG01015583001 5221759 5231216 GSVIVG01015859001 18523067 18524555 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01028858001 18042202 18045399 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01028858001 18042202 18045399 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01028858001 18042202 18045399 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01028858001 18042202 18045399 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011779001 4214635 4217647 GSVIVG01020936001 16868288 16900139 GO:0042254 ribosome biogenesis The process of the formation of the constituents of the ribosome subunits, their assembly, and their transport to the sites of protein synthesis. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01020936001 16868288 16900139 GO:0042254 ribosome biogenesis The process of the formation of the constituents of the ribosome subunits, their assembly, and their transport to the sites of protein synthesis. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01027664001 14521029 14530827 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. IEA GO:0004175 endopeptidase activity GSVIVG01027664001 14521029 14530827 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01027664001 14521029 14530827 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01020186001 9306047 9307010 GSVIVG01034156001 14784198 14791090 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01030273001 9638560 9639490 GSVIVG01001633001 21582306 21584412 GSVIVG01030958001 19702712 19702993 GSVIVG01012687001 649235 651940 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA GSVIVG01012687001 649235 651940 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01008023001 6588505 6590555 GSVIVG01008055001 6187383 6189951 GSVIVG01036210001 9003937 9005570 GSVIVG01038541001 11291945 11296799 GO:0006779 porphyrin biosynthetic process The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01038541001 11291945 11296799 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01038541001 11291945 11296799 GO:0033014 tetrapyrrole biosynthetic process The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01038541001 11291945 11296799 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01038541001 11291945 11296799 GO:0006779 porphyrin biosynthetic process The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: shikimate + NADP+ = 5-dehydroshikimate + NADPH + H+. IEA GO:0004764 shikimate 5-dehydrogenase activity GSVIVG01038541001 11291945 11296799 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: shikimate + NADP+ = 5-dehydroshikimate + NADPH + H+. IEA GO:0004764 shikimate 5-dehydrogenase activity GSVIVG01038541001 11291945 11296799 GO:0033014 tetrapyrrole biosynthetic process The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: shikimate + NADP+ = 5-dehydroshikimate + NADPH + H+. IEA GO:0004764 shikimate 5-dehydrogenase activity GSVIVG01038541001 11291945 11296799 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: shikimate + NADP+ = 5-dehydroshikimate + NADPH + H+. IEA GO:0004764 shikimate 5-dehydrogenase activity GSVIVG01038541001 11291945 11296799 GO:0006779 porphyrin biosynthetic process The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01038541001 11291945 11296799 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01038541001 11291945 11296799 GO:0033014 tetrapyrrole biosynthetic process The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01038541001 11291945 11296799 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01038541001 11291945 11296799 GO:0006779 porphyrin biosynthetic process The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: L-glutamate 1-semialdehyde + NADP+ + tRNA(Glu) = L-glutamyl-tRNA(Glu) + NADPH + H+. IEA GO:0008883 glutamyl-tRNA reductase activity GSVIVG01038541001 11291945 11296799 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: L-glutamate 1-semialdehyde + NADP+ + tRNA(Glu) = L-glutamyl-tRNA(Glu) + NADPH + H+. IEA GO:0008883 glutamyl-tRNA reductase activity GSVIVG01038541001 11291945 11296799 GO:0033014 tetrapyrrole biosynthetic process The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: L-glutamate 1-semialdehyde + NADP+ + tRNA(Glu) = L-glutamyl-tRNA(Glu) + NADPH + H+. IEA GO:0008883 glutamyl-tRNA reductase activity GSVIVG01038541001 11291945 11296799 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: L-glutamate 1-semialdehyde + NADP+ + tRNA(Glu) = L-glutamyl-tRNA(Glu) + NADPH + H+. IEA GO:0008883 glutamyl-tRNA reductase activity GSVIVG01038541001 11291945 11296799 GO:0006779 porphyrin biosynthetic process The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01038541001 11291945 11296799 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01038541001 11291945 11296799 GO:0033014 tetrapyrrole biosynthetic process The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01038541001 11291945 11296799 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01038541001 11291945 11296799 GO:0006779 porphyrin biosynthetic process The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01038541001 11291945 11296799 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01038541001 11291945 11296799 GO:0033014 tetrapyrrole biosynthetic process The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01038541001 11291945 11296799 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01031420001 18798364 18799143 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01019254001 2513563 2513799 GSVIVG01033080001 25585913 25587650 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01033080001 25585913 25587650 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01033080001 25585913 25587650 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01033080001 25585913 25587650 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01008434001 2103262 2107856 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01008434001 2103262 2107856 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01008434001 2103262 2107856 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01008434001 2103262 2107856 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01008434001 2103262 2107856 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032411001 27104985 27119919 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032411001 27104985 27119919 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032411001 27104985 27119919 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032411001 27104985 27119919 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01032411001 27104985 27119919 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01032411001 27104985 27119919 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01032411001 27104985 27119919 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01032411001 27104985 27119919 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01032411001 27104985 27119919 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01032411001 27104985 27119919 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01032411001 27104985 27119919 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01032411001 27104985 27119919 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01032411001 27104985 27119919 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01032411001 27104985 27119919 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01032411001 27104985 27119919 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01032411001 27104985 27119919 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01032411001 27104985 27119919 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01032411001 27104985 27119919 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01004484001 38822256 38824981 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01004484001 38822256 38824981 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01004484001 38822256 38824981 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01004484001 38822256 38824981 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01004484001 38822256 38824981 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01004484001 38822256 38824981 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01004484001 38822256 38824981 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01004484001 38822256 38824981 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01004484001 38822256 38824981 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01004484001 38822256 38824981 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01004484001 38822256 38824981 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01004484001 38822256 38824981 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01004484001 38822256 38824981 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01004484001 38822256 38824981 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01004484001 38822256 38824981 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01004484001 38822256 38824981 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01004484001 38822256 38824981 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01004484001 38822256 38824981 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01004484001 38822256 38824981 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01004484001 38822256 38824981 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01004484001 38822256 38824981 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01004484001 38822256 38824981 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01004484001 38822256 38824981 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01004484001 38822256 38824981 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01004484001 38822256 38824981 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate. IEA GO:0019001 guanyl nucleotide binding GSVIVG01004484001 38822256 38824981 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate. IEA GO:0019001 guanyl nucleotide binding GSVIVG01004484001 38822256 38824981 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate. IEA GO:0019001 guanyl nucleotide binding GSVIVG01004484001 38822256 38824981 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate. IEA GO:0019001 guanyl nucleotide binding GSVIVG01004484001 38822256 38824981 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate. IEA GO:0019001 guanyl nucleotide binding GSVIVG01004484001 38822256 38824981 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate. IEA GO:0019001 guanyl nucleotide binding GSVIVG01020183001 9337035 9338314 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GSVIVG01020183001 9337035 9338314 GO:0009607 response to biotic stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism. IEA GSVIVG01034155001 14792412 14795088 GSVIVG01003691001 12251828 12254859 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003691001 12251828 12254859 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003691001 12251828 12254859 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003691001 12251828 12254859 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01003691001 12251828 12254859 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01003691001 12251828 12254859 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01003691001 12251828 12254859 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01003691001 12251828 12254859 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01003691001 12251828 12254859 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016091001 18736511 18739988 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01016091001 18736511 18739988 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037171001 28342544 28345315 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036594001 18824623 18836613 GSVIVG01004436001 38521755 38522627 GSVIVG01036581001 18534479 18549622 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01036581001 18534479 18549622 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01026365001 15084285 15085366 GSVIVG01011425001 29558557 29560132 GSVIVG01037267001 16710789 16713367 GSVIVG01016439001 3899990 3904738 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01016439001 3899990 3904738 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01016439001 3899990 3904738 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01016439001 3899990 3904738 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01012125001 1219790 1221546 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01011663001 5434034 5434186 GSVIVG01023542001 9921694 9931601 GSVIVG01028210001 4648735 4654333 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01028210001 4648735 4654333 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01028210001 4648735 4654333 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01028210001 4648735 4654333 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000226001 16254593 16256503 GO:0007049 cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01000226001 16254593 16256503 GO:0051301 cell division The process resulting in the physical partitioning and separation of a cell into daughter cells. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01011748001 4583157 4585054 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01011748001 4583157 4585054 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01011748001 4583157 4585054 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01011748001 4583157 4585054 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01011748001 4583157 4585054 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01011748001 4583157 4585054 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01011748001 4583157 4585054 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01011748001 4583157 4585054 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01038187001 24193637 24200956 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01038187001 24193637 24200956 GO:0048193 Golgi vesicle transport The directed movement of substances into, out of or within the Golgi apparatus, mediated by vesicles. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020780001 2066202 2096776 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01016415001 4142622 4142663 GSVIVG01002020001 32326989 32329223 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01002020001 32326989 32329223 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01002020001 32326989 32329223 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01002020001 32326989 32329223 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. IEA GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GSVIVG01002020001 32326989 32329223 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. IEA GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GSVIVG01002020001 32326989 32329223 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. IEA GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GSVIVG01023937001 2334482 2338229 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA GSVIVG01019071001 17094880 17107573 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01020361001 20583944 20587021 GSVIVG01034695001 7859416 7860377 GSVIVG01035530001 2067296 2069858 GSVIVG01000665001 20547961 20562741 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01000665001 20547961 20562741 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01000665001 20547961 20562741 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01000665001 20547961 20562741 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01000665001 20547961 20562741 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000665001 20547961 20562741 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018063001 6025514 6051172 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018063001 6025514 6051172 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018063001 6025514 6051172 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018063001 6025514 6051172 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018063001 6025514 6051172 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018063001 6025514 6051172 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018063001 6025514 6051172 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01018063001 6025514 6051172 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01018063001 6025514 6051172 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01004750001 15940074 15944196 GSVIVG01021360001 4435330 4437358 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016679001 328735 329600 GSVIVG01027066001 18205728 18209305 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027066001 18205728 18209305 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027066001 18205728 18209305 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027066001 18205728 18209305 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027066001 18205728 18209305 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01027066001 18205728 18209305 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01010707001 12161112 12179107 GSVIVG01033622001 19155367 19165547 GSVIVG01006684001 27499725 27500564 GSVIVG01019105001 16735502 16735771 GSVIVG01037181001 28267994 28270421 GSVIVG01023587001 7667692 7689143 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01023587001 7667692 7689143 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01029992001 8769964 8770538 GSVIVG01032989001 24903072 24918092 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032989001 24903072 24918092 GO:0006013 mannose metabolic process The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032989001 24903072 24918092 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01032989001 24903072 24918092 GO:0006013 mannose metabolic process The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01032989001 24903072 24918092 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. IEA GO:0004559 alpha-mannosidase activity GSVIVG01032989001 24903072 24918092 GO:0006013 mannose metabolic process The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins. IEA Catalysis of the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. IEA GO:0004559 alpha-mannosidase activity GSVIVG01032989001 24903072 24918092 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01032989001 24903072 24918092 GO:0006013 mannose metabolic process The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01032989001 24903072 24918092 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of mannosyl compounds, substances containing a group derived from a cyclic form of mannose or a mannose derivative. IEA GO:0015923 mannosidase activity GSVIVG01032989001 24903072 24918092 GO:0006013 mannose metabolic process The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins. IEA Catalysis of the hydrolysis of mannosyl compounds, substances containing a group derived from a cyclic form of mannose or a mannose derivative. IEA GO:0015923 mannosidase activity GSVIVG01032989001 24903072 24918092 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01032989001 24903072 24918092 GO:0006013 mannose metabolic process The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins. IEA Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01032855001 220508 225885 GSVIVG01031284001 617834 618494 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01030359001 4954050 4955029 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01014403001 3412514 3414239 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01023699001 9538580 9561355 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023699001 9538580 9561355 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01023699001 9538580 9561355 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives. IEA GO:0018024 histone-lysine N-methyltransferase activity GSVIVG01033565001 19718509 19731192 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033565001 19718509 19731192 Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity. IEA GO:0004721 phosphoprotein phosphatase activity GSVIVG01037180001 28271405 28273634 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01037180001 28271405 28273634 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01035985001 6814069 6844194 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01035985001 6814069 6844194 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01035985001 6814069 6844194 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01031791001 4405632 4406580 GSVIVG01030490001 6135741 6138437 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01030490001 6135741 6138437 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01030490001 6135741 6138437 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01023955001 2195625 2200680 GSVIVG01010228001 17965019 17966964 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01010228001 17965019 17966964 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01010612001 16027556 16046231 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01010612001 16027556 16046231 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01010612001 16027556 16046231 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01010612001 16027556 16046231 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01010612001 16027556 16046231 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01010612001 16027556 16046231 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01029984001 2705866 2723903 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with a mating-type factor pheromone to initiate a change in cell activity. IEA GO:0004932 mating-type factor pheromone receptor activity GSVIVG01028225001 4756844 4768878 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01028225001 4756844 4768878 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01013229001 6513127 6524677 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: N-acetyl-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate. IEA GO:0004610 phosphoacetylglucosamine mutase activity GSVIVG01013229001 6513127 6524677 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the transfer of a phosphate group from one position to another within a single molecule. IEA GO:0016868 intramolecular transferase activity, phosphotransferases GSVIVG01002939001 37273526 37277447 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001113001 22715106 22716003 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01001113001 22715106 22716003 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01001113001 22715106 22716003 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01001113001 22715106 22716003 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01001113001 22715106 22716003 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01001113001 22715106 22716003 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01001113001 22715106 22716003 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01001113001 22715106 22716003 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01001113001 22715106 22716003 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01011420001 29535161 29536515 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01024027001 1661190 1662457 GO:0019941 modification-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01024027001 1661190 1662457 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01024027001 1661190 1662457 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01024027001 1661190 1662457 GO:0019941 modification-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01024027001 1661190 1662457 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01024027001 1661190 1662457 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01037686001 6882419 6884988 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01037686001 6882419 6884988 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01037686001 6882419 6884988 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01037686001 6882419 6884988 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01037686001 6882419 6884988 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01037686001 6882419 6884988 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01025987001 26248388 26249251 GSVIVG01030245001 9938254 9939721 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030245001 9938254 9939721 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030245001 9938254 9939721 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030245001 9938254 9939721 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030245001 9938254 9939721 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01030245001 9938254 9939721 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01030245001 9938254 9939721 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01030245001 9938254 9939721 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01030245001 9938254 9939721 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01030245001 9938254 9939721 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01030245001 9938254 9939721 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01030245001 9938254 9939721 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01030245001 9938254 9939721 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01030245001 9938254 9939721 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01030245001 9938254 9939721 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01030245001 9938254 9939721 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01030245001 9938254 9939721 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01030245001 9938254 9939721 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01030245001 9938254 9939721 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01030245001 9938254 9939721 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01030245001 9938254 9939721 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01030245001 9938254 9939721 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01030245001 9938254 9939721 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01030245001 9938254 9939721 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01016658001 178485 182939 GSVIVG01027822001 8179522 8185638 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01010974001 2510391 2512126 GSVIVG01034637001 13578464 13581056 GSVIVG01003711001 15120559 15127684 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003711001 15120559 15127684 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003711001 15120559 15127684 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003711001 15120559 15127684 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA Catalysis of the reaction: tRNA-uracil + acceptor = tRNA-dihydrouridine + reduced acceptor. IEA GO:0017150 tRNA dihydrouridine synthase activity GSVIVG01003711001 15120559 15127684 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: tRNA-uracil + acceptor = tRNA-dihydrouridine + reduced acceptor. IEA GO:0017150 tRNA dihydrouridine synthase activity GSVIVG01003711001 15120559 15127684 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: tRNA-uracil + acceptor = tRNA-dihydrouridine + reduced acceptor. IEA GO:0017150 tRNA dihydrouridine synthase activity GSVIVG01003711001 15120559 15127684 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01003711001 15120559 15127684 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01003711001 15120559 15127684 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01014189001 1346882 1349339 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014189001 1346882 1349339 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014189001 1346882 1349339 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014189001 1346882 1349339 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014189001 1346882 1349339 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033963001 16253447 16261320 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033963001 16253447 16261320 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033963001 16253447 16261320 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033963001 16253447 16261320 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033963001 16253447 16261320 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033963001 16253447 16261320 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033963001 16253447 16261320 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033963001 16253447 16261320 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033963001 16253447 16261320 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033963001 16253447 16261320 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033963001 16253447 16261320 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033963001 16253447 16261320 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033963001 16253447 16261320 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033963001 16253447 16261320 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033963001 16253447 16261320 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033963001 16253447 16261320 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033963001 16253447 16261320 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033963001 16253447 16261320 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008129001 5529705 5544382 Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01013805001 7409159 7410338 GSVIVG01033506001 20190341 20197407 GSVIVG01004832001 5507980 5508728 GSVIVG01017680001 2586109 2591430 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01017680001 2586109 2591430 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01017680001 2586109 2591430 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01017680001 2586109 2591430 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01017680001 2586109 2591430 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006099001 41461157 41462764 GSVIVG01024120001 922119 927953 GSVIVG01008951001 3759265 3763554 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Stimulates the hydrolysis and exchange of adenyl nucleotides by other proteins. IEA GO:0000774 adenyl-nucleotide exchange factor activity GSVIVG01008951001 3759265 3763554 GO:0030150 protein import into mitochondrial matrix The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Stimulates the hydrolysis and exchange of adenyl nucleotides by other proteins. IEA GO:0000774 adenyl-nucleotide exchange factor activity GSVIVG01008951001 3759265 3763554 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01008951001 3759265 3763554 GO:0030150 protein import into mitochondrial matrix The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01008951001 3759265 3763554 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with an identical protein to form a homodimer. IEA GO:0042803 protein homodimerization activity GSVIVG01008951001 3759265 3763554 GO:0030150 protein import into mitochondrial matrix The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with an identical protein to form a homodimer. IEA GO:0042803 protein homodimerization activity GSVIVG01008951001 3759265 3763554 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport. IEA GO:0051087 chaperone binding GSVIVG01008951001 3759265 3763554 GO:0030150 protein import into mitochondrial matrix The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport. IEA GO:0051087 chaperone binding GSVIVG01012434001 737475 738133 GSVIVG01006767001 28279735 28285717 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01006767001 28279735 28285717 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006767001 28279735 28285717 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01006767001 28279735 28285717 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01010240001 18125931 18140256 GSVIVG01008854001 2845415 2847132 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01008854001 2845415 2847132 Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. IEA GO:0008171 O-methyltransferase activity GSVIVG01008854001 2845415 2847132 The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01001829001 26140843 26146287 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017214001 5499684 5501391 GSVIVG01000655001 20452070 20462047 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000655001 20452070 20462047 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000655001 20452070 20462047 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000655001 20452070 20462047 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020839001 1242568 1246511 GSVIVG01025305001 2249182 2252084 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025305001 2249182 2252084 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01024909001 6110123 6114421 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01024909001 6110123 6114421 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01024909001 6110123 6114421 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01024909001 6110123 6114421 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01038764001 664462 680153 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01038764001 664462 680153 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01038764001 664462 680153 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01038764001 664462 680153 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01038764001 664462 680153 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033156001 8600289 8616390 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01033156001 8600289 8616390 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01033156001 8600289 8616390 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01033156001 8600289 8616390 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01033156001 8600289 8616390 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01033156001 8600289 8616390 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01033156001 8600289 8616390 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033156001 8600289 8616390 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033156001 8600289 8616390 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033156001 8600289 8616390 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033156001 8600289 8616390 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033156001 8600289 8616390 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033156001 8600289 8616390 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033156001 8600289 8616390 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033156001 8600289 8616390 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033156001 8600289 8616390 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033156001 8600289 8616390 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033156001 8600289 8616390 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033156001 8600289 8616390 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01033156001 8600289 8616390 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01033156001 8600289 8616390 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01033156001 8600289 8616390 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01033156001 8600289 8616390 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01033156001 8600289 8616390 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01033156001 8600289 8616390 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01033156001 8600289 8616390 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01033156001 8600289 8616390 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01033156001 8600289 8616390 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01033156001 8600289 8616390 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01033156001 8600289 8616390 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01003236001 8042987 8044366 GSVIVG01022993001 17212234 17213401 GSVIVG01033502001 20206832 20217326 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033502001 20206832 20217326 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01000846001 2867042 2867807 GSVIVG01035750001 3971723 3977416 GSVIVG01029952001 2053554 2059055 GSVIVG01025693001 12914952 12920417 GO:0009416 response to light stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01025693001 12914952 12920417 GO:0009416 response to light stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025087001 4628865 4630162 GSVIVG01036096001 20727637 20732016 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01036096001 20727637 20732016 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01036096001 20727637 20732016 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01036397001 4608908 4611080 GSVIVG01035788001 4330633 4333507 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01035788001 4330633 4333507 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01035788001 4330633 4333507 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01035788001 4330633 4333507 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01038655001 21165378 21168368 Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. IEA GO:0008171 O-methyltransferase activity GSVIVG01023625001 8188628 8191865 GSVIVG01023835001 3097459 3103030 GSVIVG01000075001 3268894 3269152 GSVIVG01014395001 3339944 3347539 GSVIVG01033325001 21485403 21494488 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01002533001 35234287 35237010 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01002533001 35234287 35237010 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01002533001 35234287 35237010 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01002533001 35234287 35237010 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006037001 23374263 23377648 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004197 cysteine-type endopeptidase activity GSVIVG01032658001 1747714 1751444 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01032658001 1747714 1751444 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032658001 1747714 1751444 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01025572001 13976818 13979949 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025572001 13976818 13979949 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. IEA GO:0004722 protein serine/threonine phosphatase activity GSVIVG01036973001 9385654 9388831 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01036973001 9385654 9388831 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01036973001 9385654 9388831 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the formation of a 2,3-epoxide in squalene. IEA GO:0004506 squalene monooxygenase activity GSVIVG01036973001 9385654 9388831 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the formation of a 2,3-epoxide in squalene. IEA GO:0004506 squalene monooxygenase activity GSVIVG01036973001 9385654 9388831 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01036973001 9385654 9388831 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01036973001 9385654 9388831 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01036973001 9385654 9388831 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01016766001 1164535 1167444 GO:0000045 autophagic vacuole assembly The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA GSVIVG01037212001 27926186 27927919 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01037212001 27926186 27927919 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01037212001 27926186 27927919 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01024756001 7192216 7193925 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01024756001 7192216 7193925 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01024756001 7192216 7193925 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01024756001 7192216 7193925 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024756001 7192216 7193925 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01024756001 7192216 7193925 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01013637001 2024991 2025501 GSVIVG01016721001 647255 649434 GSVIVG01031311001 466541 478622 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01031311001 466541 478622 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01031311001 466541 478622 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01031311001 466541 478622 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01031311001 466541 478622 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031311001 466541 478622 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031311001 466541 478622 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01031311001 466541 478622 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01031311001 466541 478622 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01031311001 466541 478622 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01013375001 852593 859459 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01013375001 852593 859459 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01013375001 852593 859459 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01013375001 852593 859459 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032463001 27686761 27687973 GSVIVG01027124001 17635542 17639230 GSVIVG01014998001 284011 306001 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01014998001 284011 306001 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01014998001 284011 306001 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01014998001 284011 306001 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01014998001 284011 306001 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01014998001 284011 306001 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01037396001 14402370 14412293 GSVIVG01024688001 7699060 7702375 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01028084001 3687146 3696030 GO:0006221 pyrimidine nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028084001 3687146 3696030 GO:0006221 pyrimidine nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. IEA Catalysis of the reaction: ATP + UTP + NH3 = ADP + phosphate + CTP. IEA GO:0003883 CTP synthase activity GSVIVG01035782001 4241393 4244043 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01029687001 13045817 13054879 GSVIVG01035720001 3645978 3647113 GSVIVG01029186001 18771344 18772297 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid. IEA GO:0008378 galactosyltransferase activity GSVIVG01004124001 15083434 15087490 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01004124001 15083434 15087490 GO:0006284 base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01004124001 15083434 15087490 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01004124001 15083434 15087490 GO:0006284 base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01004124001 15083434 15087490 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. IEA GO:0004519 endonuclease activity GSVIVG01004124001 15083434 15087490 GO:0006284 base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. IEA GO:0004519 endonuclease activity GSVIVG01004124001 15083434 15087490 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01004124001 15083434 15087490 GO:0006284 base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01004124001 15083434 15087490 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051539 4 iron, 4 sulfur cluster binding GSVIVG01004124001 15083434 15087490 GO:0006284 base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. IEA Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051539 4 iron, 4 sulfur cluster binding GSVIVG01022185001 17263584 17264818 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01022185001 17263584 17264818 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01022185001 17263584 17264818 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01022185001 17263584 17264818 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01024169001 624672 632248 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024169001 624672 632248 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024169001 624672 632248 GO:0045226 extracellular polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024169001 624672 632248 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024169001 624672 632248 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024169001 624672 632248 GO:0045226 extracellular polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024169001 624672 632248 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + NADPH + H+. IEA GO:0008831 dTDP-4-dehydrorhamnose reductase activity GSVIVG01024169001 624672 632248 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + NADPH + H+. IEA GO:0008831 dTDP-4-dehydrorhamnose reductase activity GSVIVG01024169001 624672 632248 GO:0045226 extracellular polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. IEA Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + NADPH + H+. IEA GO:0008831 dTDP-4-dehydrorhamnose reductase activity GSVIVG01024169001 624672 632248 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01024169001 624672 632248 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01024169001 624672 632248 GO:0045226 extracellular polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01008986001 4068936 4069717 GSVIVG01012228001 400560 418459 GO:0006529 asparagine biosynthetic process The chemical reactions and pathways resulting in the formation of asparagine, 2-amino-3-carbamoylpropanoic acid. IEA Catalysis of the reaction: ATP + L-aspartate + L-glutamine = AMP + diphosphate + L-asparagine + L-glutamate. IEA GO:0004066 asparagine synthase (glutamine-hydrolyzing) activity GSVIVG01035565001 2344162 2361062 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035565001 2344162 2361062 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035565001 2344162 2361062 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01035565001 2344162 2361062 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01035565001 2344162 2361062 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01035565001 2344162 2361062 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01006333001 24956351 24964000 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01006333001 24956351 24964000 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01022231001 17704312 17706001 GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA GSVIVG01037861001 7039334 7043015 GSVIVG01034393001 16898205 16898495 GSVIVG01033966001 16234151 16238581 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01033966001 16234151 16238581 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01033966001 16234151 16238581 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01033966001 16234151 16238581 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01033966001 16234151 16238581 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01033966001 16234151 16238581 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01036920001 17600963 17602444 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GSVIVG01000256001 20596048 20597073 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01000256001 20596048 20597073 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01000256001 20596048 20597073 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01000256001 20596048 20597073 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012036001 1967827 1973352 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GSVIVG01003435001 15016616 15018620 GSVIVG01011654001 5571717 5579866 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01011654001 5571717 5579866 Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01011654001 5571717 5579866 Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01002248001 33627367 33628210 GSVIVG01016491001 3441693 3443711 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016491001 3441693 3443711 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016491001 3441693 3443711 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016491001 3441693 3443711 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01016491001 3441693 3443711 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01016491001 3441693 3443711 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01016491001 3441693 3443711 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016491001 3441693 3443711 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016491001 3441693 3443711 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016491001 3441693 3443711 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01016491001 3441693 3443711 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01016491001 3441693 3443711 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01016491001 3441693 3443711 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016491001 3441693 3443711 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016491001 3441693 3443711 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01007645001 10878778 10880874 GSVIVG01020980001 15967370 15971395 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020980001 15967370 15971395 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020980001 15967370 15971395 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020980001 15967370 15971395 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020980001 15967370 15971395 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01020980001 15967370 15971395 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01020980001 15967370 15971395 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01020980001 15967370 15971395 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01031073001 21837507 21842950 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01036910001 17785702 17785983 GSVIVG01000177001 15913499 15915174 GSVIVG01035787001 4318172 4319763 GSVIVG01010898001 16015035 16018455 GSVIVG01032625001 2094819 2097062 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01032625001 2094819 2097062 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032625001 2094819 2097062 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01032625001 2094819 2097062 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01014426001 3626941 3634812 GSVIVG01016310001 5251124 5269297 GO:0001522 pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01016310001 5251124 5269297 GO:0009451 RNA modification The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01016310001 5251124 5269297 GO:0001522 pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs. IEA Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. IEA GO:0009982 pseudouridine synthase activity GSVIVG01016310001 5251124 5269297 GO:0009451 RNA modification The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. IEA Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. IEA GO:0009982 pseudouridine synthase activity GSVIVG01024989001 5455599 5456523 GSVIVG01015216001 1884996 1889121 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015216001 1884996 1889121 Catalysis of the reaction: cytidine + H2O = uridine + NH3. IEA GO:0004126 cytidine deaminase activity GSVIVG01015216001 1884996 1889121 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01017960001 5092692 5096187 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01017960001 5092692 5096187 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019029001 17578959 17583726 GSVIVG01034016001 15825138 15826694 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: a 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-delta(4)-steroid + reduced acceptor. IEA GO:0003865 3-oxo-5-alpha-steroid 4-dehydrogenase activity GSVIVG01034016001 15825138 15826694 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-delta(4)-steroid + reduced acceptor. IEA GO:0003865 3-oxo-5-alpha-steroid 4-dehydrogenase activity GSVIVG01034016001 15825138 15826694 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-delta(4)-steroid + reduced acceptor. IEA GO:0003865 3-oxo-5-alpha-steroid 4-dehydrogenase activity GSVIVG01034016001 15825138 15826694 GO:0008202 steroid metabolic process The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: a 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-delta(4)-steroid + reduced acceptor. IEA GO:0003865 3-oxo-5-alpha-steroid 4-dehydrogenase activity GSVIVG01034016001 15825138 15826694 GO:0008202 steroid metabolic process The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-delta(4)-steroid + reduced acceptor. IEA GO:0003865 3-oxo-5-alpha-steroid 4-dehydrogenase activity GSVIVG01034016001 15825138 15826694 GO:0008202 steroid metabolic process The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-delta(4)-steroid + reduced acceptor. IEA GO:0003865 3-oxo-5-alpha-steroid 4-dehydrogenase activity GSVIVG01034016001 15825138 15826694 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: a 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-delta(4)-steroid + reduced acceptor. IEA GO:0003865 3-oxo-5-alpha-steroid 4-dehydrogenase activity GSVIVG01034016001 15825138 15826694 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-delta(4)-steroid + reduced acceptor. IEA GO:0003865 3-oxo-5-alpha-steroid 4-dehydrogenase activity GSVIVG01034016001 15825138 15826694 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-delta(4)-steroid + reduced acceptor. IEA GO:0003865 3-oxo-5-alpha-steroid 4-dehydrogenase activity GSVIVG01034016001 15825138 15826694 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GSVIVG01034016001 15825138 15826694 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GSVIVG01034016001 15825138 15826694 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GSVIVG01034016001 15825138 15826694 GO:0008202 steroid metabolic process The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GSVIVG01034016001 15825138 15826694 GO:0008202 steroid metabolic process The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GSVIVG01034016001 15825138 15826694 GO:0008202 steroid metabolic process The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GSVIVG01034016001 15825138 15826694 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GSVIVG01034016001 15825138 15826694 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GSVIVG01034016001 15825138 15826694 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GSVIVG01028636001 11372095 11377675 Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01028636001 11372095 11377675 Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01028636001 11372095 11377675 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01027252001 17580599 17583046 GO:0006777 Mo-molybdopterin cofactor biosynthetic process The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands. IEA GSVIVG01018797001 19772673 19782459 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032433001 27348198 27357069 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01032433001 27348198 27357069 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01032433001 27348198 27357069 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01032433001 27348198 27357069 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032433001 27348198 27357069 Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01032433001 27348198 27357069 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01034209001 14416399 14420572 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01034209001 14416399 14420572 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01034209001 14416399 14420572 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01034209001 14416399 14420572 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01034209001 14416399 14420572 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01034209001 14416399 14420572 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01034209001 14416399 14420572 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01034209001 14416399 14420572 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01034209001 14416399 14420572 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01034209001 14416399 14420572 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01034209001 14416399 14420572 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01034209001 14416399 14420572 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01034209001 14416399 14420572 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01034209001 14416399 14420572 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01034209001 14416399 14420572 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01034209001 14416399 14420572 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01034209001 14416399 14420572 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01034209001 14416399 14420572 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01034209001 14416399 14420572 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01034209001 14416399 14420572 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01002881001 36958646 36964194 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01002881001 36958646 36964194 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01000424001 7794670 7795342 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01000424001 7794670 7795342 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01000424001 7794670 7795342 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01000424001 7794670 7795342 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013232001 6488601 6498446 GSVIVG01038505001 10625770 10626610 GSVIVG01027684001 14338657 14343093 GSVIVG01017272001 6229947 6230462 GSVIVG01002751001 36367362 36368402 GSVIVG01000006001 2643130 2644348 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01020703001 2990225 2994516 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01020703001 2990225 2994516 GO:0009231 riboflavin biosynthetic process The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01020703001 2990225 2994516 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: ATP + riboflavin = ADP + FMN. IEA GO:0008531 riboflavin kinase activity GSVIVG01020703001 2990225 2994516 GO:0009231 riboflavin biosynthetic process The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). IEA Catalysis of the reaction: ATP + riboflavin = ADP + FMN. IEA GO:0008531 riboflavin kinase activity GSVIVG01020703001 2990225 2994516 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2-phosphoglycolate + H2O = glycolate + phosphate. IEA GO:0008967 phosphoglycolate phosphatase activity GSVIVG01020703001 2990225 2994516 GO:0009231 riboflavin biosynthetic process The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). IEA Catalysis of the reaction: 2-phosphoglycolate + H2O = glycolate + phosphate. IEA GO:0008967 phosphoglycolate phosphatase activity GSVIVG01020703001 2990225 2994516 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01020703001 2990225 2994516 GO:0009231 riboflavin biosynthetic process The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01027081001 18115493 18118575 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion. IEA GO:0004806 triglyceride lipase activity GSVIVG01038700001 20838696 20844278 GSVIVG01025307001 2228790 2231610 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025307001 2228790 2231610 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025307001 2228790 2231610 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025307001 2228790 2231610 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01025307001 2228790 2231610 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01025307001 2228790 2231610 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01016869001 2133152 2136775 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01016869001 2133152 2136775 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01016869001 2133152 2136775 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01016869001 2133152 2136775 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01016869001 2133152 2136775 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01016869001 2133152 2136775 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01035130001 1699774 1706856 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0000015 phosphopyruvate hydratase complex A multimeric enzyme complex, usually a dimer or an octamer, that catalyzes the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate and water. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01035130001 1699774 1706856 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0000015 phosphopyruvate hydratase complex A multimeric enzyme complex, usually a dimer or an octamer, that catalyzes the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate and water. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01035130001 1699774 1706856 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0000015 phosphopyruvate hydratase complex A multimeric enzyme complex, usually a dimer or an octamer, that catalyzes the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate and water. IEA Catalysis of the reaction: 2-phospho-D-glycerate = phosphoenolpyruvate + H2O. IEA GO:0004634 phosphopyruvate hydratase activity GSVIVG01035130001 1699774 1706856 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0000015 phosphopyruvate hydratase complex A multimeric enzyme complex, usually a dimer or an octamer, that catalyzes the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate and water. IEA Catalysis of the reaction: 2-phospho-D-glycerate = phosphoenolpyruvate + H2O. IEA GO:0004634 phosphopyruvate hydratase activity GSVIVG01035130001 1699774 1706856 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0000015 phosphopyruvate hydratase complex A multimeric enzyme complex, usually a dimer or an octamer, that catalyzes the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate and water. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01035130001 1699774 1706856 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0000015 phosphopyruvate hydratase complex A multimeric enzyme complex, usually a dimer or an octamer, that catalyzes the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate and water. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01014846001 10511019 10515821 GSVIVG01021883001 6054487 6056026 GSVIVG01010561001 16627241 16629171 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010561001 16627241 16629171 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010561001 16627241 16629171 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010561001 16627241 16629171 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01010561001 16627241 16629171 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01010561001 16627241 16629171 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01010561001 16627241 16629171 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01010561001 16627241 16629171 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01010561001 16627241 16629171 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01010561001 16627241 16629171 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01010561001 16627241 16629171 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01010561001 16627241 16629171 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01017762001 3217986 3244322 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01017762001 3217986 3244322 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01017762001 3217986 3244322 GO:0006428 isoleucyl-tRNA aminoacylation The process of coupling isoleucine to isoleucyl-tRNA, catalyzed by isoleucyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01017762001 3217986 3244322 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01017762001 3217986 3244322 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01017762001 3217986 3244322 GO:0006428 isoleucyl-tRNA aminoacylation The process of coupling isoleucine to isoleucyl-tRNA, catalyzed by isoleucyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01017762001 3217986 3244322 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01017762001 3217986 3244322 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01017762001 3217986 3244322 GO:0006428 isoleucyl-tRNA aminoacylation The process of coupling isoleucine to isoleucyl-tRNA, catalyzed by isoleucyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01017762001 3217986 3244322 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile). IEA GO:0004822 isoleucine-tRNA ligase activity GSVIVG01017762001 3217986 3244322 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile). IEA GO:0004822 isoleucine-tRNA ligase activity GSVIVG01017762001 3217986 3244322 GO:0006428 isoleucyl-tRNA aminoacylation The process of coupling isoleucine to isoleucyl-tRNA, catalyzed by isoleucyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile). IEA GO:0004822 isoleucine-tRNA ligase activity GSVIVG01017762001 3217986 3244322 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017762001 3217986 3244322 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017762001 3217986 3244322 GO:0006428 isoleucyl-tRNA aminoacylation The process of coupling isoleucine to isoleucyl-tRNA, catalyzed by isoleucyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017762001 3217986 3244322 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01017762001 3217986 3244322 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01017762001 3217986 3244322 GO:0006428 isoleucyl-tRNA aminoacylation The process of coupling isoleucine to isoleucyl-tRNA, catalyzed by isoleucyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01036828001 17624789 17625250 GSVIVG01024815001 6664355 6666363 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01024815001 6664355 6666363 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0043626 PCNA complex A protein complex composed of three identical PCNA monomers, each comprising two similar domains, which are joined in a head-to-tail arrangement to form a homotrimer. Forms a ring-like structure in solution, with a central hole sufficiently large to accommodate the double helix of DNA. Originally characterized as a DNA sliding clamp for replicative DNA polymerases and as an essential component of the replisome, and has also been shown to be involved in other processes including Okazaki fragment processing, DNA repair, translesion DNA synthesis, DNA methylation, chromatin remodeling and cell cycle regulation. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01024815001 6664355 6666363 GO:0006275 regulation of DNA replication Any process that modulates the frequency, rate or extent of DNA replication. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01024815001 6664355 6666363 GO:0006275 regulation of DNA replication Any process that modulates the frequency, rate or extent of DNA replication. IEA GO:0043626 PCNA complex A protein complex composed of three identical PCNA monomers, each comprising two similar domains, which are joined in a head-to-tail arrangement to form a homotrimer. Forms a ring-like structure in solution, with a central hole sufficiently large to accommodate the double helix of DNA. Originally characterized as a DNA sliding clamp for replicative DNA polymerases and as an essential component of the replisome, and has also been shown to be involved in other processes including Okazaki fragment processing, DNA repair, translesion DNA synthesis, DNA methylation, chromatin remodeling and cell cycle regulation. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01024815001 6664355 6666363 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA An enzyme regulator activity that increases the processivity of polymerization by DNA polymerase, by allowing the polymerase to move rapidly along DNA while remaining topologically bound to it. IEA GO:0030337 DNA polymerase processivity factor activity GSVIVG01024815001 6664355 6666363 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0043626 PCNA complex A protein complex composed of three identical PCNA monomers, each comprising two similar domains, which are joined in a head-to-tail arrangement to form a homotrimer. Forms a ring-like structure in solution, with a central hole sufficiently large to accommodate the double helix of DNA. Originally characterized as a DNA sliding clamp for replicative DNA polymerases and as an essential component of the replisome, and has also been shown to be involved in other processes including Okazaki fragment processing, DNA repair, translesion DNA synthesis, DNA methylation, chromatin remodeling and cell cycle regulation. IEA An enzyme regulator activity that increases the processivity of polymerization by DNA polymerase, by allowing the polymerase to move rapidly along DNA while remaining topologically bound to it. IEA GO:0030337 DNA polymerase processivity factor activity GSVIVG01024815001 6664355 6666363 GO:0006275 regulation of DNA replication Any process that modulates the frequency, rate or extent of DNA replication. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA An enzyme regulator activity that increases the processivity of polymerization by DNA polymerase, by allowing the polymerase to move rapidly along DNA while remaining topologically bound to it. IEA GO:0030337 DNA polymerase processivity factor activity GSVIVG01024815001 6664355 6666363 GO:0006275 regulation of DNA replication Any process that modulates the frequency, rate or extent of DNA replication. IEA GO:0043626 PCNA complex A protein complex composed of three identical PCNA monomers, each comprising two similar domains, which are joined in a head-to-tail arrangement to form a homotrimer. Forms a ring-like structure in solution, with a central hole sufficiently large to accommodate the double helix of DNA. Originally characterized as a DNA sliding clamp for replicative DNA polymerases and as an essential component of the replisome, and has also been shown to be involved in other processes including Okazaki fragment processing, DNA repair, translesion DNA synthesis, DNA methylation, chromatin remodeling and cell cycle regulation. IEA An enzyme regulator activity that increases the processivity of polymerization by DNA polymerase, by allowing the polymerase to move rapidly along DNA while remaining topologically bound to it. IEA GO:0030337 DNA polymerase processivity factor activity GSVIVG01035564001 2332532 2334116 GSVIVG01001423001 18987562 19001786 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01001423001 18987562 19001786 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01001423001 18987562 19001786 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01001423001 18987562 19001786 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01001423001 18987562 19001786 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01001423001 18987562 19001786 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01001423001 18987562 19001786 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01001423001 18987562 19001786 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01021192001 2451215 2455731 GSVIVG01017851001 4030154 4031701 GSVIVG01029551001 21683537 21689887 GSVIVG01020078001 10605111 10607758 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01020078001 10605111 10607758 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01020078001 10605111 10607758 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01020078001 10605111 10607758 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01020078001 10605111 10607758 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01020078001 10605111 10607758 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01020078001 10605111 10607758 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01020078001 10605111 10607758 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01010214001 17604978 17705405 GO:0032312 regulation of ARF GTPase activity Any process that modulates the activity of the GTPase ARF. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01010214001 17604978 17705405 GO:0032312 regulation of ARF GTPase activity Any process that modulates the activity of the GTPase ARF. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Increases the rate of GTP hydrolysis by the GTPase ARF. IEA GO:0008060 ARF GTPase activator activity GSVIVG01010214001 17604978 17705405 GO:0032312 regulation of ARF GTPase activity Any process that modulates the activity of the GTPase ARF. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01016787001 1370944 1371330 GSVIVG01025533001 14258497 14259684 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025533001 14258497 14259684 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01003933001 8077137 8081967 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01003933001 8077137 8081967 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01003933001 8077137 8081967 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01003933001 8077137 8081967 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01003933001 8077137 8081967 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01003933001 8077137 8081967 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01003933001 8077137 8081967 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01003933001 8077137 8081967 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01003933001 8077137 8081967 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01003933001 8077137 8081967 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01003933001 8077137 8081967 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01003933001 8077137 8081967 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01006119001 41783516 41783884 GSVIVG01023795001 3421314 3425591 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01023795001 3421314 3425591 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027219001 18028684 18029660 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01004006001 14265823 14269339 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01026094001 24632904 24636927 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01026094001 24632904 24636927 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01026094001 24632904 24636927 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01026094001 24632904 24636927 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01026094001 24632904 24636927 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01026094001 24632904 24636927 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01026094001 24632904 24636927 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01026094001 24632904 24636927 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01026094001 24632904 24636927 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01026094001 24632904 24636927 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01026094001 24632904 24636927 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01026094001 24632904 24636927 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01026094001 24632904 24636927 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01026094001 24632904 24636927 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01026094001 24632904 24636927 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01026094001 24632904 24636927 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01026094001 24632904 24636927 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01026094001 24632904 24636927 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01026094001 24632904 24636927 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01026094001 24632904 24636927 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01026094001 24632904 24636927 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01026094001 24632904 24636927 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01026094001 24632904 24636927 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01026094001 24632904 24636927 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01026094001 24632904 24636927 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01026094001 24632904 24636927 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026094001 24632904 24636927 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026094001 24632904 24636927 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026094001 24632904 24636927 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026094001 24632904 24636927 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026094001 24632904 24636927 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01026094001 24632904 24636927 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01026094001 24632904 24636927 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01026094001 24632904 24636927 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01026094001 24632904 24636927 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01026094001 24632904 24636927 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01026094001 24632904 24636927 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01026094001 24632904 24636927 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01026094001 24632904 24636927 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01026094001 24632904 24636927 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01024497001 3339213 3339806 GSVIVG01028398001 7128793 7132543 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01028398001 7128793 7132543 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01028398001 7128793 7132543 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01028398001 7128793 7132543 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01028398001 7128793 7132543 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01004841001 5582143 5591653 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01020764001 2274502 2275916 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020764001 2274502 2275916 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01026507001 22468203 22470668 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026507001 22468203 22470668 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026507001 22468203 22470668 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026507001 22468203 22470668 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026507001 22468203 22470668 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01026507001 22468203 22470668 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01026507001 22468203 22470668 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01026507001 22468203 22470668 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01026507001 22468203 22470668 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01026507001 22468203 22470668 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01007245001 31079578 31079991 GSVIVG01023252001 20551763 20552767 GSVIVG01022106001 16615965 16618016 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01022106001 16615965 16618016 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01012283001 12982490 12982534 GSVIVG01011016001 2189454 2189897 GSVIVG01015388001 3203127 3215223 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01015388001 3203127 3215223 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01015388001 3203127 3215223 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01015388001 3203127 3215223 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01007555001 12203723 12206685 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01004639001 39304907 39306554 GSVIVG01000547001 7234008 7236189 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01023894001 2617962 2619973 GSVIVG01012049001 1797847 1814503 GSVIVG01035688001 3337923 3339472 GSVIVG01002279001 33951625 33955386 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA GSVIVG01014139001 729371 729718 GSVIVG01020157001 9697620 9711615 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01020157001 9697620 9711615 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01030219001 10337041 10344443 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01030219001 10337041 10344443 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01030219001 10337041 10344443 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01030219001 10337041 10344443 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01011544001 12649058 12674003 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01011544001 12649058 12674003 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01012166001 888711 895574 GSVIVG01025260001 2620800 2629824 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025260001 2620800 2629824 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). IEA GO:0016769 transferase activity, transferring nitrogenous groups GSVIVG01025260001 2620800 2629824 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01020798001 1843248 1851708 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020798001 1843248 1851708 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01000114001 15369757 15370393 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01000114001 15369757 15370393 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01000114001 15369757 15370393 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015934 large ribosomal subunit The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01003780001 12613937 12620836 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01003780001 12613937 12620836 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01010505001 21177722 21180031 GSVIVG01007227001 30964385 30966631 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01018044001 5771283 5772296 GSVIVG01038090001 23397413 23403662 GSVIVG01037217001 27867278 27871145 GSVIVG01034978001 615166 645269 GSVIVG01031122001 1965866 1976219 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031122001 1965866 1976219 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01031122001 1965866 1976219 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031122001 1965866 1976219 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0008236 serine-type peptidase activity GSVIVG01009084001 4815727 4855448 GO:0006400 tRNA modification The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically. IEA Catalysis of the reaction: tRNA guanine + queuine = tRNA queuine + guanine. IEA GO:0008479 queuine tRNA-ribosyltransferase activity GSVIVG01009084001 4815727 4855448 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA Catalysis of the reaction: tRNA guanine + queuine = tRNA queuine + guanine. IEA GO:0008479 queuine tRNA-ribosyltransferase activity GSVIVG01009084001 4815727 4855448 GO:0008616 queuosine biosynthetic process The chemical reactions and pathways resulting in the formation of queuosines, any of a series of nucleosides found in tRNA and having an additional pentenyl ring added via an NH group to the methyl group of 7-methylguanosine. The pentenyl ring may carry other substituents. IEA Catalysis of the reaction: tRNA guanine + queuine = tRNA queuine + guanine. IEA GO:0008479 queuine tRNA-ribosyltransferase activity GSVIVG01019465001 863509 867965 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020856001 950078 968807 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020856001 950078 968807 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020856001 950078 968807 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020856001 950078 968807 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020856001 950078 968807 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01020856001 950078 968807 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01021723001 10096795 10097987 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021723001 10096795 10097987 Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01021878001 6092977 6096631 GO:0006535 cysteine biosynthetic process from serine The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021878001 6092977 6096631 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021878001 6092977 6096631 GO:0006535 cysteine biosynthetic process from serine The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01021878001 6092977 6096631 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01006733001 27830272 27836573 GO:0001539 ciliary or flagellar motility Cell motility due to movement of cilia or flagella. IEA GO:0009428 bacterial-type flagellum basal body, distal rod, P ring One of the rings of the flagellar basal body; anchors the basal body to the peptidoglycan layer. Examples of this component are found in bacteria. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01006733001 27830272 27836573 GO:0001539 ciliary or flagellar motility Cell motility due to movement of cilia or flagella. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01024383001 1825043 1829641 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01026833001 20108856 20114200 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026833001 20108856 20114200 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026833001 20108856 20114200 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026833001 20108856 20114200 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026833001 20108856 20114200 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026833001 20108856 20114200 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026833001 20108856 20114200 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01026833001 20108856 20114200 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01026833001 20108856 20114200 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01026833001 20108856 20114200 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01026833001 20108856 20114200 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01026833001 20108856 20114200 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01020151001 9772922 9786128 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005578 proteinaceous extracellular matrix A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01020151001 9772922 9786128 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0031012 extracellular matrix A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as in plants). IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01020151001 9772922 9786128 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005578 proteinaceous extracellular matrix A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01020151001 9772922 9786128 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0031012 extracellular matrix A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as in plants). IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01020151001 9772922 9786128 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005578 proteinaceous extracellular matrix A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008237 metallopeptidase activity GSVIVG01020151001 9772922 9786128 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0031012 extracellular matrix A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as in plants). IEA Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008237 metallopeptidase activity GSVIVG01020151001 9772922 9786128 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005578 proteinaceous extracellular matrix A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008237 metallopeptidase activity GSVIVG01020151001 9772922 9786128 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0031012 extracellular matrix A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as in plants). IEA Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008237 metallopeptidase activity GSVIVG01028460001 7916686 7916811 GSVIVG01008901001 3253824 3256064 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GSVIVG01008901001 3253824 3256064 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GSVIVG01013907001 6651931 6652187 GSVIVG01013415001 613490 614195 GSVIVG01014383001 3276228 3277109 GSVIVG01034966001 507913 523990 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01034966001 507913 523990 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01034966001 507913 523990 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01034966001 507913 523990 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01003635001 568393 569859 GSVIVG01020886001 17742397 17744652 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01020886001 17742397 17744652 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01024534001 9087481 9091737 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01036980001 9311015 9314129 GSVIVG01028066001 3571377 3572639 GSVIVG01026858001 19883958 19907011 GSVIVG01012121001 1245113 1248294 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01012121001 1245113 1248294 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01033271001 21962576 21970146 GSVIVG01013144001 7638413 7641328 GSVIVG01029419001 17018288 17018503 GSVIVG01017153001 4750111 4761693 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA GSVIVG01003858001 12939230 12948543 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01019756001 3019594 3022040 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003252001 8351411 8360444 GSVIVG01024250001 188435 204895 GSVIVG01010482001 20952347 20953480 GSVIVG01017472001 8918525 8959271 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01011076001 1781896 1786997 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017048001 3769982 3770804 GSVIVG01018308001 11300088 11327403 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01018308001 11300088 11327403 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01018308001 11300088 11327403 GO:0006425 glutaminyl-tRNA aminoacylation The process of coupling glutamine to glutaminyl-tRNA, catalyzed by glutaminyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'- adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01018308001 11300088 11327403 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01018308001 11300088 11327403 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01018308001 11300088 11327403 GO:0006425 glutaminyl-tRNA aminoacylation The process of coupling glutamine to glutaminyl-tRNA, catalyzed by glutaminyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'- adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01018308001 11300088 11327403 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln). IEA GO:0004819 glutamine-tRNA ligase activity GSVIVG01018308001 11300088 11327403 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln). IEA GO:0004819 glutamine-tRNA ligase activity GSVIVG01018308001 11300088 11327403 GO:0006425 glutaminyl-tRNA aminoacylation The process of coupling glutamine to glutaminyl-tRNA, catalyzed by glutaminyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'- adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln). IEA GO:0004819 glutamine-tRNA ligase activity GSVIVG01018308001 11300088 11327403 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018308001 11300088 11327403 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018308001 11300088 11327403 GO:0006425 glutaminyl-tRNA aminoacylation The process of coupling glutamine to glutaminyl-tRNA, catalyzed by glutaminyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'- adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031300001 538926 540436 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01031300001 538926 540436 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01013461001 257298 263356 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01013461001 257298 263356 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01013461001 257298 263356 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01013461001 257298 263356 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01013461001 257298 263356 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01013461001 257298 263356 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01013461001 257298 263356 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013461001 257298 263356 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034835001 22416678 22417853 GSVIVG01032343001 15324760 15325209 GSVIVG01025134001 4060980 4063585 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0005835 fatty acid synthase complex A multienzyme complex that catalyses the synthesis of fatty acids from acetyl CoA. IEA Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+. IEA GO:0004312 fatty acid synthase activity GSVIVG01025134001 4060980 4063585 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005835 fatty acid synthase complex A multienzyme complex that catalyses the synthesis of fatty acids from acetyl CoA. IEA Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+. IEA GO:0004312 fatty acid synthase activity GSVIVG01025134001 4060980 4063585 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005835 fatty acid synthase complex A multienzyme complex that catalyses the synthesis of fatty acids from acetyl CoA. IEA Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+. IEA GO:0004312 fatty acid synthase activity GSVIVG01025134001 4060980 4063585 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0005835 fatty acid synthase complex A multienzyme complex that catalyses the synthesis of fatty acids from acetyl CoA. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025134001 4060980 4063585 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005835 fatty acid synthase complex A multienzyme complex that catalyses the synthesis of fatty acids from acetyl CoA. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025134001 4060980 4063585 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005835 fatty acid synthase complex A multienzyme complex that catalyses the synthesis of fatty acids from acetyl CoA. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01034251001 13488697 13492124 GSVIVG01012169001 806983 839693 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01012169001 806983 839693 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01012169001 806983 839693 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012169001 806983 839693 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012169001 806983 839693 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012169001 806983 839693 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012169001 806983 839693 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01012169001 806983 839693 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01034378001 17158756 17161629 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011400001 29344663 29346160 GSVIVG01009290001 7027039 7030753 GSVIVG01028421001 7403133 7410929 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA GSVIVG01015610001 14035377 14036296 GSVIVG01035527001 2031917 2032612 GSVIVG01004093001 14737392 14744073 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01004093001 14737392 14744073 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01004093001 14737392 14744073 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01009950001 12763411 12766861 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01009950001 12763411 12766861 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01009950001 12763411 12766861 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01009950001 12763411 12766861 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010945001 2779615 2782680 GSVIVG01001050001 7056518 7060532 GSVIVG01036821001 17494098 17503316 GSVIVG01028725001 19388139 19394697 GSVIVG01022685001 14951308 14983872 GO:0006306 DNA methylation The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01022685001 14951308 14983872 GO:0006306 DNA methylation The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01022685001 14951308 14983872 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01022685001 14951308 14983872 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01022685001 14951308 14983872 GO:0006306 DNA methylation The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Interacting selectively and non-covalently with chromatin, the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase. IEA GO:0003682 chromatin binding GSVIVG01022685001 14951308 14983872 GO:0006306 DNA methylation The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with chromatin, the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase. IEA GO:0003682 chromatin binding GSVIVG01022685001 14951308 14983872 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Interacting selectively and non-covalently with chromatin, the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase. IEA GO:0003682 chromatin binding GSVIVG01022685001 14951308 14983872 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with chromatin, the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase. IEA GO:0003682 chromatin binding GSVIVG01012702001 836493 839989 GO:0006546 glycine catabolic process The chemical reactions and pathways resulting in the breakdown of glycine, aminoethanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: (6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein = (6R)-5,10-methylenetetrahydrofolate + NH3 + dihydrolipoylprotein. IEA GO:0004047 aminomethyltransferase activity GSVIVG01019545001 1500921 1506241 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019545001 1500921 1506241 GO:0006012 galactose metabolic process The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019545001 1500921 1506241 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019545001 1500921 1506241 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019545001 1500921 1506241 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019545001 1500921 1506241 GO:0045226 extracellular polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019545001 1500921 1506241 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: UDP-glucose = UDP-galactose. IEA GO:0003978 UDP-glucose 4-epimerase activity GSVIVG01019545001 1500921 1506241 GO:0006012 galactose metabolic process The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. IEA Catalysis of the reaction: UDP-glucose = UDP-galactose. IEA GO:0003978 UDP-glucose 4-epimerase activity GSVIVG01019545001 1500921 1506241 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: UDP-glucose = UDP-galactose. IEA GO:0003978 UDP-glucose 4-epimerase activity GSVIVG01019545001 1500921 1506241 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: UDP-glucose = UDP-galactose. IEA GO:0003978 UDP-glucose 4-epimerase activity GSVIVG01019545001 1500921 1506241 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of the reaction: UDP-glucose = UDP-galactose. IEA GO:0003978 UDP-glucose 4-epimerase activity GSVIVG01019545001 1500921 1506241 GO:0045226 extracellular polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. IEA Catalysis of the reaction: UDP-glucose = UDP-galactose. IEA GO:0003978 UDP-glucose 4-epimerase activity GSVIVG01019545001 1500921 1506241 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019545001 1500921 1506241 GO:0006012 galactose metabolic process The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019545001 1500921 1506241 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019545001 1500921 1506241 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019545001 1500921 1506241 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019545001 1500921 1506241 GO:0045226 extracellular polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019545001 1500921 1506241 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + NADPH + H+. IEA GO:0008831 dTDP-4-dehydrorhamnose reductase activity GSVIVG01019545001 1500921 1506241 GO:0006012 galactose metabolic process The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. IEA Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + NADPH + H+. IEA GO:0008831 dTDP-4-dehydrorhamnose reductase activity GSVIVG01019545001 1500921 1506241 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + NADPH + H+. IEA GO:0008831 dTDP-4-dehydrorhamnose reductase activity GSVIVG01019545001 1500921 1506241 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + NADPH + H+. IEA GO:0008831 dTDP-4-dehydrorhamnose reductase activity GSVIVG01019545001 1500921 1506241 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + NADPH + H+. IEA GO:0008831 dTDP-4-dehydrorhamnose reductase activity GSVIVG01019545001 1500921 1506241 GO:0045226 extracellular polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. IEA Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + NADPH + H+. IEA GO:0008831 dTDP-4-dehydrorhamnose reductase activity GSVIVG01019545001 1500921 1506241 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01019545001 1500921 1506241 GO:0006012 galactose metabolic process The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01019545001 1500921 1506241 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01019545001 1500921 1506241 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01019545001 1500921 1506241 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01019545001 1500921 1506241 GO:0045226 extracellular polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01019545001 1500921 1506241 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. IEA GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GSVIVG01019545001 1500921 1506241 GO:0006012 galactose metabolic process The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. IEA Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. IEA GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GSVIVG01019545001 1500921 1506241 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. IEA GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GSVIVG01019545001 1500921 1506241 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. IEA GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GSVIVG01019545001 1500921 1506241 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. IEA GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GSVIVG01019545001 1500921 1506241 GO:0045226 extracellular polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. IEA Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. IEA GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GSVIVG01019545001 1500921 1506241 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01019545001 1500921 1506241 GO:0006012 galactose metabolic process The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01019545001 1500921 1506241 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01019545001 1500921 1506241 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01019545001 1500921 1506241 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01019545001 1500921 1506241 GO:0045226 extracellular polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01004375001 38310877 38312252 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01004375001 38310877 38312252 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01007671001 10614427 10630758 GO:0016575 histone deacetylation The modification of histones by removal of acetyl groups. IEA Catalysis of the hydrolysis of acetyl groups from histones, proteins complexed to DNA in chromatin and chromosomes. IEA GO:0004407 histone deacetylase activity GSVIVG01028514001 8984793 8985582 GSVIVG01008578001 746760 748821 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008578001 746760 748821 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008578001 746760 748821 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008578001 746760 748821 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008578001 746760 748821 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008578001 746760 748821 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008578001 746760 748821 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01008578001 746760 748821 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01008578001 746760 748821 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01008578001 746760 748821 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008578001 746760 748821 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008578001 746760 748821 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033693001 18595276 18602103 GSVIVG01027746001 7368012 7369801 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01027746001 7368012 7369801 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01034067001 15437149 15438314 GSVIVG01004747001 15851605 15865261 GSVIVG01001188001 981646 986273 Catalysis of the removal of a phosphate group from phosphorylated myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol. IEA GO:0004437 inositol or phosphatidylinositol phosphatase activity GSVIVG01034109001 15095129 15106015 GSVIVG01027339001 16304157 16318962 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01020674001 3191916 3194884 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion. IEA GO:0004806 triglyceride lipase activity GSVIVG01036529001 23084806 23088774 Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01013920001 6813595 6813930 GSVIVG01013915001 6693709 6702231 GSVIVG01020566001 4242618 4265306 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01020566001 4242618 4265306 GO:0019509 L-methionine salvage from methylthioadenosine The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01020566001 4242618 4265306 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reactions: 5-(methylthio)-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate (1a) 5-(methylthio)-2,3-dioxopentyl phosphate = 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate (1b) 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate. IEA GO:0043874 acireductone synthase activity GSVIVG01020566001 4242618 4265306 GO:0019509 L-methionine salvage from methylthioadenosine The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine. IEA Catalysis of the reactions: 5-(methylthio)-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate (1a) 5-(methylthio)-2,3-dioxopentyl phosphate = 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate (1b) 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate. IEA GO:0043874 acireductone synthase activity GSVIVG01020566001 4242618 4265306 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01020566001 4242618 4265306 GO:0019509 L-methionine salvage from methylthioadenosine The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01010774001 22468994 22471732 GSVIVG01038172001 24056737 24058478 GO:0006631 fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01038172001 24056737 24058478 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01038172001 24056737 24058478 GO:0006631 fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. IEA Catalysis of the reaction: stearoyl-[acyl-carrier protein] + reduced acceptor + O2 = oleoyl-[acyl-carrier protein] + acceptor + H2O. The enzyme requires ferredoxin. IEA GO:0045300 acyl-[acyl-carrier-protein] desaturase activity GSVIVG01038172001 24056737 24058478 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: stearoyl-[acyl-carrier protein] + reduced acceptor + O2 = oleoyl-[acyl-carrier protein] + acceptor + H2O. The enzyme requires ferredoxin. IEA GO:0045300 acyl-[acyl-carrier-protein] desaturase activity GSVIVG01038172001 24056737 24058478 GO:0006631 fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01038172001 24056737 24058478 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01030879001 18287617 18290031 GSVIVG01038096001 23471448 23475044 GSVIVG01028838001 18233568 18235457 GSVIVG01012574001 3927602 3931198 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01012574001 3927602 3931198 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01012574001 3927602 3931198 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01000224001 16242881 16246098 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01000224001 16242881 16246098 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01000224001 16242881 16246098 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01000224001 16242881 16246098 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01000224001 16242881 16246098 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01000224001 16242881 16246098 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01000224001 16242881 16246098 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01000224001 16242881 16246098 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01000224001 16242881 16246098 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01000224001 16242881 16246098 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01000224001 16242881 16246098 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01000224001 16242881 16246098 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01036851001 18028102 18028743 GSVIVG01025060001 4866794 4869872 GSVIVG01015162001 1470782 1476384 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01015162001 1470782 1476384 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01015162001 1470782 1476384 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01015162001 1470782 1476384 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01015162001 1470782 1476384 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01015162001 1470782 1476384 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01015162001 1470782 1476384 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01015162001 1470782 1476384 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01015162001 1470782 1476384 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01015162001 1470782 1476384 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01015162001 1470782 1476384 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01015162001 1470782 1476384 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01015162001 1470782 1476384 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015162001 1470782 1476384 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015162001 1470782 1476384 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030284001 9483459 9485661 GSVIVG01030602001 7066944 7076302 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01030602001 7066944 7076302 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01030602001 7066944 7076302 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01030602001 7066944 7076302 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01030602001 7066944 7076302 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01030602001 7066944 7076302 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01030602001 7066944 7076302 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01030602001 7066944 7076302 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01030602001 7066944 7076302 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01030602001 7066944 7076302 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01030602001 7066944 7076302 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01030602001 7066944 7076302 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01030602001 7066944 7076302 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01030602001 7066944 7076302 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01030602001 7066944 7076302 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01030602001 7066944 7076302 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01030602001 7066944 7076302 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01030602001 7066944 7076302 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01030602001 7066944 7076302 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01030602001 7066944 7076302 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01030602001 7066944 7076302 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01030602001 7066944 7076302 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01030602001 7066944 7076302 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01030602001 7066944 7076302 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01030602001 7066944 7076302 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01030602001 7066944 7076302 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01030602001 7066944 7076302 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01030602001 7066944 7076302 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01030602001 7066944 7076302 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01030602001 7066944 7076302 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01030602001 7066944 7076302 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01030602001 7066944 7076302 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01030602001 7066944 7076302 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01030602001 7066944 7076302 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01030602001 7066944 7076302 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01030602001 7066944 7076302 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01030602001 7066944 7076302 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01030602001 7066944 7076302 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01030602001 7066944 7076302 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01030602001 7066944 7076302 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01030602001 7066944 7076302 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01030602001 7066944 7076302 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01030602001 7066944 7076302 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01030602001 7066944 7076302 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01030602001 7066944 7076302 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01030602001 7066944 7076302 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01030602001 7066944 7076302 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01030602001 7066944 7076302 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01030602001 7066944 7076302 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01030602001 7066944 7076302 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01030602001 7066944 7076302 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01030602001 7066944 7076302 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01030602001 7066944 7076302 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01030602001 7066944 7076302 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01030602001 7066944 7076302 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01030602001 7066944 7076302 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01030602001 7066944 7076302 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01030602001 7066944 7076302 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01030602001 7066944 7076302 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01030602001 7066944 7076302 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01030602001 7066944 7076302 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01030602001 7066944 7076302 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01030602001 7066944 7076302 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01030602001 7066944 7076302 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01030602001 7066944 7076302 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01030602001 7066944 7076302 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01030602001 7066944 7076302 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01030602001 7066944 7076302 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01030602001 7066944 7076302 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01030602001 7066944 7076302 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01030602001 7066944 7076302 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01030602001 7066944 7076302 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01030602001 7066944 7076302 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01030602001 7066944 7076302 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01030602001 7066944 7076302 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01030602001 7066944 7076302 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01030602001 7066944 7076302 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01030602001 7066944 7076302 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01030602001 7066944 7076302 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01030602001 7066944 7076302 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01030602001 7066944 7076302 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01030602001 7066944 7076302 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01030602001 7066944 7076302 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01030602001 7066944 7076302 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01030602001 7066944 7076302 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01030602001 7066944 7076302 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01030602001 7066944 7076302 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01030602001 7066944 7076302 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01030602001 7066944 7076302 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01030602001 7066944 7076302 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01030602001 7066944 7076302 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01030602001 7066944 7076302 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01030602001 7066944 7076302 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01030602001 7066944 7076302 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01030602001 7066944 7076302 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01030602001 7066944 7076302 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01030602001 7066944 7076302 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01030602001 7066944 7076302 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01030602001 7066944 7076302 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01030602001 7066944 7076302 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01030602001 7066944 7076302 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01030602001 7066944 7076302 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01030602001 7066944 7076302 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01030602001 7066944 7076302 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01030602001 7066944 7076302 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01030602001 7066944 7076302 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01030602001 7066944 7076302 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01030602001 7066944 7076302 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01030602001 7066944 7076302 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01030602001 7066944 7076302 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01030602001 7066944 7076302 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01030602001 7066944 7076302 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01030602001 7066944 7076302 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01030602001 7066944 7076302 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01030602001 7066944 7076302 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01030602001 7066944 7076302 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01030602001 7066944 7076302 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01030602001 7066944 7076302 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01030602001 7066944 7076302 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01030602001 7066944 7076302 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01030602001 7066944 7076302 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01030602001 7066944 7076302 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01030602001 7066944 7076302 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01030602001 7066944 7076302 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01030602001 7066944 7076302 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01030602001 7066944 7076302 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01030602001 7066944 7076302 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01030602001 7066944 7076302 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01030602001 7066944 7076302 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01030602001 7066944 7076302 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01030602001 7066944 7076302 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01030602001 7066944 7076302 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01030602001 7066944 7076302 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01030602001 7066944 7076302 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01030602001 7066944 7076302 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01030602001 7066944 7076302 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01030602001 7066944 7076302 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01030602001 7066944 7076302 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01030602001 7066944 7076302 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01030602001 7066944 7076302 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01030602001 7066944 7076302 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01030602001 7066944 7076302 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01030602001 7066944 7076302 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01030602001 7066944 7076302 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01030602001 7066944 7076302 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01030602001 7066944 7076302 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01030602001 7066944 7076302 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01030602001 7066944 7076302 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01030602001 7066944 7076302 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01030602001 7066944 7076302 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01030602001 7066944 7076302 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01030602001 7066944 7076302 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01030602001 7066944 7076302 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01030602001 7066944 7076302 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01030602001 7066944 7076302 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01030602001 7066944 7076302 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01030602001 7066944 7076302 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01030602001 7066944 7076302 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01030602001 7066944 7076302 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01030602001 7066944 7076302 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01030602001 7066944 7076302 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01030602001 7066944 7076302 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01030602001 7066944 7076302 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01030602001 7066944 7076302 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01030602001 7066944 7076302 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01030602001 7066944 7076302 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01030602001 7066944 7076302 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01030602001 7066944 7076302 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01030602001 7066944 7076302 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030602001 7066944 7076302 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030602001 7066944 7076302 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030602001 7066944 7076302 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030602001 7066944 7076302 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030602001 7066944 7076302 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030602001 7066944 7076302 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030602001 7066944 7076302 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030602001 7066944 7076302 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030602001 7066944 7076302 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030602001 7066944 7076302 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030602001 7066944 7076302 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030602001 7066944 7076302 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030602001 7066944 7076302 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030602001 7066944 7076302 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030602001 7066944 7076302 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030602001 7066944 7076302 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030602001 7066944 7076302 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030602001 7066944 7076302 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030602001 7066944 7076302 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030602001 7066944 7076302 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030602001 7066944 7076302 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030602001 7066944 7076302 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030602001 7066944 7076302 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030602001 7066944 7076302 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030602001 7066944 7076302 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030602001 7066944 7076302 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030602001 7066944 7076302 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030602001 7066944 7076302 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01030602001 7066944 7076302 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01030602001 7066944 7076302 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01030602001 7066944 7076302 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01030602001 7066944 7076302 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01030602001 7066944 7076302 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01030602001 7066944 7076302 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01030602001 7066944 7076302 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01030602001 7066944 7076302 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01030602001 7066944 7076302 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01030602001 7066944 7076302 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01030602001 7066944 7076302 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01030602001 7066944 7076302 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01030602001 7066944 7076302 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01030602001 7066944 7076302 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01030602001 7066944 7076302 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01030602001 7066944 7076302 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01030602001 7066944 7076302 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01030602001 7066944 7076302 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01030602001 7066944 7076302 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01030602001 7066944 7076302 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01030602001 7066944 7076302 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01030602001 7066944 7076302 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01030602001 7066944 7076302 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01030602001 7066944 7076302 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01030602001 7066944 7076302 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01030602001 7066944 7076302 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01030602001 7066944 7076302 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01035823001 4666598 4671922 GSVIVG01003753001 12369414 12373017 GSVIVG01031118001 2019696 2027984 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0008076 voltage-gated potassium channel complex A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01027526001 15980195 15985559 GSVIVG01036752001 22999084 22999621 GSVIVG01013739001 8012586 8021182 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01013739001 8012586 8021182 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01013739001 8012586 8021182 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01013739001 8012586 8021182 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019574001 1698358 1698741 Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01027541001 15891923 15894930 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01027541001 15891923 15894930 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01027541001 15891923 15894930 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01027541001 15891923 15894930 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01030029001 8999971 9000576 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01008591001 581998 588367 GO:0001522 pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01008591001 581998 588367 GO:0009451 RNA modification The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01008591001 581998 588367 GO:0001522 pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs. IEA Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. IEA GO:0009982 pseudouridine synthase activity GSVIVG01008591001 581998 588367 GO:0009451 RNA modification The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. IEA Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. IEA GO:0009982 pseudouridine synthase activity GSVIVG01033369001 21157608 21164081 GSVIVG01021741001 10377113 10389381 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01036394001 4580039 4581412 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GSVIVG01000481001 14613170 14618041 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01019016001 17711959 17747277 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008235 metalloexopeptidase activity GSVIVG01019016001 17711959 17747277 GO:0009987 cellular process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008235 metalloexopeptidase activity GSVIVG01019016001 17711959 17747277 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01019016001 17711959 17747277 GO:0009987 cellular process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01016151001 19877498 19887091 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01016151001 19877498 19887091 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030126 COPI vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01016151001 19877498 19887091 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01016151001 19877498 19887091 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030126 COPI vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01016151001 19877498 19887091 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016151001 19877498 19887091 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030126 COPI vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016151001 19877498 19887091 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016151001 19877498 19887091 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030126 COPI vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016151001 19877498 19887091 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016151001 19877498 19887091 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030126 COPI vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016151001 19877498 19887091 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016151001 19877498 19887091 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030126 COPI vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01011453001 29770208 29771593 GSVIVG01010171001 16740977 16743471 GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010171001 16740977 16743471 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010171001 16740977 16743471 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010171001 16740977 16743471 GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. IEA Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+. IEA GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity GSVIVG01010171001 16740977 16743471 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+. IEA GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity GSVIVG01010171001 16740977 16743471 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+. IEA GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity GSVIVG01010171001 16740977 16743471 GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01010171001 16740977 16743471 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01010171001 16740977 16743471 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01029251001 18007531 18008250 GSVIVG01016534001 3033731 3040966 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033340001 21358075 21359919 GSVIVG01016232001 6170311 6176567 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01029206001 18570410 18571312 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01029206001 18570410 18571312 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01029206001 18570410 18571312 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01029206001 18570410 18571312 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01029206001 18570410 18571312 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA Interacting selectively and non-covalently with damaged DNA. IEA GO:0003684 damaged DNA binding GSVIVG01029206001 18570410 18571312 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Interacting selectively and non-covalently with damaged DNA. IEA GO:0003684 damaged DNA binding GSVIVG01029206001 18570410 18571312 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029206001 18570410 18571312 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029206001 18570410 18571312 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate in the presence of single- or double-stranded DNA; drives another reaction. IEA GO:0008094 DNA-dependent ATPase activity GSVIVG01029206001 18570410 18571312 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate in the presence of single- or double-stranded DNA; drives another reaction. IEA GO:0008094 DNA-dependent ATPase activity GSVIVG01029206001 18570410 18571312 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01029206001 18570410 18571312 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01016003001 17190848 17196887 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01027120001 17651433 17666598 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01029312001 17030970 17038385 GSVIVG01015331001 2756071 2760726 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01034331001 17992462 18022695 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01023135001 22226001 22228636 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Stops, prevents or reduces the activity of an enzyme. IEA GO:0004857 enzyme inhibitor activity GSVIVG01023135001 22226001 22228636 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01023135001 22226001 22228636 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the reaction: pectin + n H2O = n methanol + pectate. IEA GO:0030599 pectinesterase activity GSVIVG01023135001 22226001 22228636 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue. IEA GO:0045330 aspartyl esterase activity GSVIVG01035016001 928364 932721 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01035016001 928364 932721 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01035016001 928364 932721 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035016001 928364 932721 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035016001 928364 932721 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01035016001 928364 932721 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01035016001 928364 932721 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01035016001 928364 932721 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01035016001 928364 932721 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01035016001 928364 932721 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01029510001 22112046 22118827 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029510001 22112046 22118827 Catalysis of the transfer of a functional group from one position to another within a single molecule. IEA GO:0016866 intramolecular transferase activity GSVIVG01014279001 2290389 2291418 GSVIVG01017990001 5307187 5307921 GSVIVG01024409001 2180665 2188198 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01020304001 21643265 21643691 GSVIVG01029767001 14423503 14426102 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01029767001 14423503 14426102 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01029767001 14423503 14426102 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01029767001 14423503 14426102 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012590001 4407724 4408083 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012590001 4407724 4408083 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01026780001 7023459 7023930 GSVIVG01007867001 8174940 8184172 GO:0006564 L-serine biosynthetic process The chemical reactions and pathways resulting in the formation of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007867001 8174940 8184172 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007867001 8174940 8184172 GO:0006564 L-serine biosynthetic process The chemical reactions and pathways resulting in the formation of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. IEA Catalysis of the reaction: L(or D)-O-phosphoserine + H2O = L(or D)-serine + phosphate. IEA GO:0004647 phosphoserine phosphatase activity GSVIVG01007867001 8174940 8184172 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: L(or D)-O-phosphoserine + H2O = L(or D)-serine + phosphate. IEA GO:0004647 phosphoserine phosphatase activity GSVIVG01007867001 8174940 8184172 GO:0006564 L-serine biosynthetic process The chemical reactions and pathways resulting in the formation of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. IEA Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. IEA GO:0016791 phosphatase activity GSVIVG01007867001 8174940 8184172 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. IEA GO:0016791 phosphatase activity GSVIVG01028295001 5846731 5847540 GSVIVG01012214001 506835 513217 GSVIVG01020873001 737150 742258 GSVIVG01006717001 1215654 1220185 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01016528001 3094114 3102829 GO:0006614 SRP-dependent cotranslational protein targeting to membrane The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. IEA GO:0048500 signal recognition particle A complex of protein and RNA which facilitates translocation of proteins across membranes. IEA Interacting selectively and non-covalently with 7S RNA, the RNA component of the signal recognition particle (SRP). IEA GO:0008312 7S RNA binding GSVIVG01029234001 18210736 18213011 GSVIVG01033053001 25369234 25372987 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. IEA GO:0016597 amino acid binding GSVIVG01008446001 1966513 1970126 GSVIVG01021451001 5528169 5530014 GSVIVG01032727001 1216114 1219327 GSVIVG01011503001 30079465 30081266 GSVIVG01033871001 17116757 17125269 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01033871001 17116757 17125269 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01005833001 22129735 22134315 GSVIVG01019618001 1998985 2003828 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0000159 protein phosphatase type 2A complex A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit. IEA Modulation of the activity of the enzyme protein phosphatase type 2A. IEA GO:0008601 protein phosphatase type 2A regulator activity GSVIVG01022635001 13939743 13940883 GSVIVG01004036001 14420531 14421550 GSVIVG01027752001 7409856 7411681 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01027752001 7409856 7411681 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01000331001 11438316 11441974 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01000331001 11438316 11441974 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01014611001 5676840 5712392 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01014611001 5676840 5712392 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0030127 COPII vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01014611001 5676840 5712392 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01014611001 5676840 5712392 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030127 COPII vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01014611001 5676840 5712392 GO:0006888 ER to Golgi vesicle-mediated transport The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01014611001 5676840 5712392 GO:0006888 ER to Golgi vesicle-mediated transport The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi. IEA GO:0030127 COPII vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01014611001 5676840 5712392 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA A ligand-dependent receptor found in the nucleus of the cell. IEA GO:0004879 ligand-dependent nuclear receptor activity GSVIVG01014611001 5676840 5712392 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0030127 COPII vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state. IEA A ligand-dependent receptor found in the nucleus of the cell. IEA GO:0004879 ligand-dependent nuclear receptor activity GSVIVG01014611001 5676840 5712392 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA A ligand-dependent receptor found in the nucleus of the cell. IEA GO:0004879 ligand-dependent nuclear receptor activity GSVIVG01014611001 5676840 5712392 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030127 COPII vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state. IEA A ligand-dependent receptor found in the nucleus of the cell. IEA GO:0004879 ligand-dependent nuclear receptor activity GSVIVG01014611001 5676840 5712392 GO:0006888 ER to Golgi vesicle-mediated transport The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA A ligand-dependent receptor found in the nucleus of the cell. IEA GO:0004879 ligand-dependent nuclear receptor activity GSVIVG01014611001 5676840 5712392 GO:0006888 ER to Golgi vesicle-mediated transport The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi. IEA GO:0030127 COPII vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state. IEA A ligand-dependent receptor found in the nucleus of the cell. IEA GO:0004879 ligand-dependent nuclear receptor activity GSVIVG01014611001 5676840 5712392 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014611001 5676840 5712392 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0030127 COPII vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014611001 5676840 5712392 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014611001 5676840 5712392 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030127 COPII vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014611001 5676840 5712392 GO:0006888 ER to Golgi vesicle-mediated transport The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014611001 5676840 5712392 GO:0006888 ER to Golgi vesicle-mediated transport The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi. IEA GO:0030127 COPII vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014611001 5676840 5712392 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01014611001 5676840 5712392 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0030127 COPII vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01014611001 5676840 5712392 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01014611001 5676840 5712392 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030127 COPII vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01014611001 5676840 5712392 GO:0006888 ER to Golgi vesicle-mediated transport The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01014611001 5676840 5712392 GO:0006888 ER to Golgi vesicle-mediated transport The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi. IEA GO:0030127 COPII vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01012792001 23202825 23205937 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01012792001 23202825 23205937 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01027042001 18408267 18411314 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027042001 18408267 18411314 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. IEA GO:0016853 isomerase activity GSVIVG01027042001 18408267 18411314 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01003087001 8553882 8554443 GSVIVG01005672001 21111694 21113172 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01009296001 7062629 7067154 GSVIVG01019965001 12260037 12261821 GO:0009664 plant-type cell wall organization A process that results in the assembly and arrangement of constituent parts of the cellulose and pectin-containing cell wall, or in the disassembly of the cellulose and pectin-containing cell wall. This process is carried out at the cellular level. An example of this process is found in Arabidopsis thaliana. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA GSVIVG01036257001 7939195 7941497 GSVIVG01009122001 5274934 5280032 GSVIVG01017080001 4032912 4049768 GO:0007154 cell communication Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017080001 4032912 4049768 GO:0007154 cell communication Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. IEA Interacting selectively and non-covalently with any inositol-containing glycerophospholipid. Phosphatidylinositol (PtdIns) and its phosphorylated derivatives are collectively referred to as phosphoinositides (PIs). IEA GO:0035091 phosphoinositide binding GSVIVG01000017001 2840389 2843169 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01000017001 2840389 2843169 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01000017001 2840389 2843169 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01000017001 2840389 2843169 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007135001 30312522 30316077 GSVIVG01012069001 1646533 1652442 GSVIVG01019362001 363407 370494 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01019362001 363407 370494 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01023427001 12230660 12230779 GSVIVG01033992001 16045831 16048610 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0008076 voltage-gated potassium channel complex A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01033992001 16045831 16048610 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01033992001 16045831 16048610 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0008076 voltage-gated potassium channel complex A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033992001 16045831 16048610 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014557001 5137989 5156157 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01014557001 5137989 5156157 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01015127001 1252978 1262835 GSVIVG01014394001 3337836 3339870 GSVIVG01001133001 22873387 22877304 GSVIVG01021684001 9349968 9350747 GSVIVG01038164001 24010174 24011083 GSVIVG01034972001 572860 573024 GSVIVG01013972001 8183940 8184202 GSVIVG01032858001 185617 187453 GSVIVG01025715001 12706428 12722631 GSVIVG01018641001 11804407 11804547 GSVIVG01035204001 10402895 10446692 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035204001 10402895 10446692 GO:0009725 response to hormone stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035204001 10402895 10446692 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019732001 2809886 2813515 GSVIVG01020621001 3682983 3690713 Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. IEA GO:0008171 O-methyltransferase activity GSVIVG01033694001 18591043 18591956 GSVIVG01030464001 5810402 5815965 GSVIVG01035316001 401319 408009 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035316001 401319 408009 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008237 metallopeptidase activity GSVIVG01035316001 401319 408009 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01035316001 401319 408009 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01011103001 1566321 1571489 GSVIVG01017197001 5238578 5256303 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01017197001 5238578 5256303 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017197001 5238578 5256303 Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01017197001 5238578 5256303 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01034313001 14700138 14701629 GSVIVG01024525001 9215213 9234096 GSVIVG01035760001 4066503 4066983 GSVIVG01027424001 16836208 16840796 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027424001 16836208 16840796 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027424001 16836208 16840796 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027424001 16836208 16840796 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01027424001 16836208 16840796 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01027424001 16836208 16840796 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01027424001 16836208 16840796 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01027424001 16836208 16840796 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01027424001 16836208 16840796 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01027504001 16159005 16161694 GO:0006011 UDP-glucose metabolic process The chemical reactions and pathways involving UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01001927001 14862592 14865821 GSVIVG01036010001 7150219 7155555 GSVIVG01018161001 13755681 13756927 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01001301001 5147926 5157582 GSVIVG01033036001 25238505 25244770 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01033036001 25238505 25244770 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008470001 1659388 1663729 GSVIVG01004446001 38611948 38615656 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01004446001 38611948 38615656 Catalysis of the two-stage endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides with 2',3'-cyclic phosphate intermediates. IEA GO:0033897 ribonuclease T2 activity GSVIVG01034001001 15992791 15994433 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01016481001 3493362 3507701 Catalysis of the transfer of a nucleotidyl group to a reactant. IEA GO:0016779 nucleotidyltransferase activity GSVIVG01012716001 921207 926010 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: prephenate = phenylpyruvate + H2O + CO2. IEA GO:0004664 prephenate dehydratase activity GSVIVG01012716001 921207 926010 GO:0009094 L-phenylalanine biosynthetic process The chemical reactions and pathways resulting in the formation of L-phenylalanine, the L-enantiomer of 2-amino-3-phenylpropanoic acid, i.e. (2S)-2-amino-3-phenylpropanoic acid. IEA Catalysis of the reaction: prephenate = phenylpyruvate + H2O + CO2. IEA GO:0004664 prephenate dehydratase activity GSVIVG01012716001 921207 926010 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. IEA GO:0016597 amino acid binding GSVIVG01012716001 921207 926010 GO:0009094 L-phenylalanine biosynthetic process The chemical reactions and pathways resulting in the formation of L-phenylalanine, the L-enantiomer of 2-amino-3-phenylpropanoic acid, i.e. (2S)-2-amino-3-phenylpropanoic acid. IEA Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. IEA GO:0016597 amino acid binding GSVIVG01035835001 4760940 4761762 GSVIVG01026738001 5894099 5900453 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01026738001 5894099 5900453 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01014397001 3357593 3358448 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01014397001 3357593 3358448 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01016264001 5771590 5801747 GSVIVG01014897001 11389170 11389451 GSVIVG01016799001 1503981 1507080 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01016799001 1503981 1507080 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01019867001 4017702 4020569 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019867001 4017702 4020569 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019867001 4017702 4020569 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019867001 4017702 4020569 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019867001 4017702 4020569 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01019867001 4017702 4020569 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024777001 7029073 7045131 GO:0006506 GPI anchor biosynthetic process The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol moiety is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate moiety, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage. IEA GSVIVG01024777001 7029073 7045131 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GSVIVG01027772001 7569272 7569898 GSVIVG01017098001 4141565 4145663 GSVIVG01021021001 15181150 15183347 GO:0009168 purine ribonucleoside monophosphate biosynthetic process The chemical reactions and pathways resulting in the formation of purine ribonucleoside monophosphate, a glycosamine consisting of a purine base linked to a ribose sugar esterified with phosphate on its glycose moiety. IEA Catalysis of the removal of an amino group from a substrate, producing ammonia (NH3). IEA GO:0019239 deaminase activity GSVIVG01021633001 8465350 8466234 GSVIVG01029736001 13923058 13926706 GSVIVG01014246001 1945318 1947525 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01014246001 1945318 1947525 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01014246001 1945318 1947525 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01014246001 1945318 1947525 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01028940001 17209237 17213204 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01023439001 11921210 11931950 GSVIVG01035416001 1129965 1131911 GSVIVG01031676001 20038980 20071503 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01031676001 20038980 20071503 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01031676001 20038980 20071503 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01031676001 20038980 20071503 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01005188001 18980226 18986499 GSVIVG01028492001 8388156 8388917 GSVIVG01002949001 37331797 37336392 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01002949001 37331797 37336392 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01002949001 37331797 37336392 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01002949001 37331797 37336392 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01009846001 11745491 11746340 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01009846001 11745491 11746340 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01009846001 11745491 11746340 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01014584001 5383243 5383305 GSVIVG01024907001 6116850 6125667 GO:0006367 transcription initiation from RNA polymerase II promoter A transcription initiation process that results in RNA synthesis by RNA polymerase II. IEA GO:0005672 transcription factor TFIIA complex A component of the transcription machinery of RNA Polymerase II. In humans, TFIIA is a heterotrimer composed of an alpha (P35), beta (P19) and gamma subunits (P12). IEA Functions to initiate or regulate RNA polymerase II transcription. IEA GO:0003702 RNA polymerase II transcription factor activity GSVIVG01013993001 8638982 8639566 GSVIVG01020691001 3072679 3074306 GSVIVG01024537001 9072745 9076675 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01024537001 9072745 9076675 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01028728001 19358631 19365024 GO:0016459 myosin complex A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. IEA Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate. IEA GO:0003774 motor activity GSVIVG01024208001 260948 276256 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and carries out proton transport across a membrane. The proton-transporting domain (F0, V0, or A0) includes integral and peripheral membrane proteins. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01000937001 22067039 22072113 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01000937001 22067039 22072113 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01000937001 22067039 22072113 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01000937001 22067039 22072113 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012164001 903666 929421 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01012164001 903666 929421 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01012164001 903666 929421 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012164001 903666 929421 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012164001 903666 929421 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01012164001 903666 929421 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01012164001 903666 929421 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01012164001 903666 929421 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01036961001 9501864 9508762 GSVIVG01015009001 407975 411998 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01024757001 7184066 7191842 GSVIVG01030073001 9587814 9604039 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01030073001 9587814 9604039 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01030073001 9587814 9604039 GO:0051260 protein homooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01030073001 9587814 9604039 GO:0051260 protein homooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01030073001 9587814 9604039 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01030073001 9587814 9604039 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01030073001 9587814 9604039 GO:0051260 protein homooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01030073001 9587814 9604039 GO:0051260 protein homooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01030073001 9587814 9604039 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030073001 9587814 9604039 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030073001 9587814 9604039 GO:0051260 protein homooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030073001 9587814 9604039 GO:0051260 protein homooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030073001 9587814 9604039 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01030073001 9587814 9604039 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01030073001 9587814 9604039 GO:0051260 protein homooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01030073001 9587814 9604039 GO:0051260 protein homooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01030073001 9587814 9604039 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01030073001 9587814 9604039 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01030073001 9587814 9604039 GO:0051260 protein homooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01030073001 9587814 9604039 GO:0051260 protein homooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01030073001 9587814 9604039 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01030073001 9587814 9604039 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01030073001 9587814 9604039 GO:0051260 protein homooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01030073001 9587814 9604039 GO:0051260 protein homooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01014903001 11542313 11542532 GSVIVG01034687001 7685038 7698234 GO:0006221 pyrimidine nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01034687001 7685038 7698234 GO:0006561 proline biosynthetic process The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01034687001 7685038 7698234 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01034687001 7685038 7698234 GO:0006221 pyrimidine nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-glutamate = ADP + L-glutamate 5-phosphate. IEA GO:0004349 glutamate 5-kinase activity GSVIVG01034687001 7685038 7698234 GO:0006561 proline biosynthetic process The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-glutamate = ADP + L-glutamate 5-phosphate. IEA GO:0004349 glutamate 5-kinase activity GSVIVG01034687001 7685038 7698234 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-glutamate = ADP + L-glutamate 5-phosphate. IEA GO:0004349 glutamate 5-kinase activity GSVIVG01034687001 7685038 7698234 GO:0006221 pyrimidine nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + UMP = ADP + UDP. IEA GO:0033862 UMP kinase activity GSVIVG01034687001 7685038 7698234 GO:0006561 proline biosynthetic process The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + UMP = ADP + UDP. IEA GO:0033862 UMP kinase activity GSVIVG01034687001 7685038 7698234 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + UMP = ADP + UDP. IEA GO:0033862 UMP kinase activity GSVIVG01036114001 20543680 20551200 GSVIVG01030122001 10048658 10051051 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01000470001 8271223 8273143 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01032360001 26696925 26699961 GSVIVG01008957001 3842548 3845101 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01034140001 14883582 14886648 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01034140001 14883582 14886648 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016296001 5406579 5419713 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01016296001 5406579 5419713 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003086001 8530958 8537172 GO:0007205 activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway The initiation of the activity of the inactive enzyme protein kinase C as the result of a series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol 3-phosphate. IEA GO:0004143 diacylglycerol kinase activity GSVIVG01014982001 13653087 13653826 GSVIVG01024113001 984044 985542 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01030486001 6095474 6101131 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0000159 protein phosphatase type 2A complex A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit. IEA Modulation of the activity of the enzyme protein phosphatase type 2A. IEA GO:0008601 protein phosphatase type 2A regulator activity GSVIVG01028817001 18445146 18457691 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01008534001 1033934 1037516 GSVIVG01014498001 4507989 4510361 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA GSVIVG01035340001 622697 627431 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar. IEA GO:0008375 acetylglucosaminyltransferase activity GSVIVG01035943001 6258507 6261202 GSVIVG01000654001 20442948 20445319 GO:0006207 'de novo' pyrimidine base biosynthetic process The chemical reactions and pathways resulting in the formation of pyrimidine bases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000654001 20442948 20445319 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000654001 20442948 20445319 GO:0006207 'de novo' pyrimidine base biosynthetic process The chemical reactions and pathways resulting in the formation of pyrimidine bases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors. IEA Catalysis of the reaction: orotidine 5'-phosphate = UMP + CO2. IEA GO:0004590 orotidine-5'-phosphate decarboxylase activity GSVIVG01000654001 20442948 20445319 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: orotidine 5'-phosphate = UMP + CO2. IEA GO:0004590 orotidine-5'-phosphate decarboxylase activity GSVIVG01009182001 5846804 5850896 GSVIVG01011835001 3742315 3754441 GSVIVG01008439001 2044017 2044579 GSVIVG01018358001 10462328 10462831 GSVIVG01022714001 15478836 15480948 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. IEA GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GSVIVG01009512001 8971444 8971686 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01009512001 8971444 8971686 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01009512001 8971444 8971686 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01009512001 8971444 8971686 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01009512001 8971444 8971686 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009512001 8971444 8971686 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01002593001 35333783 35337513 GSVIVG01028169001 4377203 4380857 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01028169001 4377203 4380857 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01009038001 4458540 4462708 GSVIVG01022504001 4028141 4037321 GSVIVG01035005001 835195 842179 GSVIVG01002788001 36416894 36417700 GSVIVG01027549001 15775045 15776766 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01027549001 15775045 15776766 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01027549001 15775045 15776766 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01027549001 15775045 15776766 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01027064001 18217373 18218911 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01010694001 11913312 11914463 GSVIVG01008324001 3248575 3251784 GSVIVG01031167001 1556871 1558691 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008579001 744205 746348 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008579001 744205 746348 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008579001 744205 746348 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008579001 744205 746348 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008579001 744205 746348 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008579001 744205 746348 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008579001 744205 746348 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01008579001 744205 746348 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01008579001 744205 746348 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01008579001 744205 746348 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008579001 744205 746348 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008579001 744205 746348 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01000240001 20424217 20428224 GSVIVG01019314001 1305408 1308873 GSVIVG01004117001 15022286 15026838 GSVIVG01038267001 24809273 24818854 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid. IEA GO:0008378 galactosyltransferase activity GSVIVG01037376001 14771527 14784943 GSVIVG01004813001 117846 120579 GSVIVG01008437001 2046549 2049008 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01008437001 2046549 2049008 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01008437001 2046549 2049008 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01008437001 2046549 2049008 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013767001 7763408 7789751 GO:0046854 phosphoinositide phosphorylation The process of introducing one or more phosphate groups into a phosphoinositide, a class of substances comprising phosphatidylinositol and its derivatives. IEA GO:0005942 phosphoinositide 3-kinase complex A complex containing a heterodimer of a catalytic subunit and a regulatory (adaptor) subunit of any phosphoinositide 3-kinase (PI3K). IEA Catalysis of the phosphorylation of myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol. IEA GO:0004428 inositol or phosphatidylinositol kinase activity GSVIVG01013767001 7763408 7789751 GO:0048015 phosphoinositide-mediated signaling A series of molecular signals in which a cell uses a phosphoinositide to convert an extracellular signal into a response. IEA GO:0005942 phosphoinositide 3-kinase complex A complex containing a heterodimer of a catalytic subunit and a regulatory (adaptor) subunit of any phosphoinositide 3-kinase (PI3K). IEA Catalysis of the phosphorylation of myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol. IEA GO:0004428 inositol or phosphatidylinositol kinase activity GSVIVG01013767001 7763408 7789751 GO:0046854 phosphoinositide phosphorylation The process of introducing one or more phosphate groups into a phosphoinositide, a class of substances comprising phosphatidylinositol and its derivatives. IEA GO:0005942 phosphoinositide 3-kinase complex A complex containing a heterodimer of a catalytic subunit and a regulatory (adaptor) subunit of any phosphoinositide 3-kinase (PI3K). IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01013767001 7763408 7789751 GO:0048015 phosphoinositide-mediated signaling A series of molecular signals in which a cell uses a phosphoinositide to convert an extracellular signal into a response. IEA GO:0005942 phosphoinositide 3-kinase complex A complex containing a heterodimer of a catalytic subunit and a regulatory (adaptor) subunit of any phosphoinositide 3-kinase (PI3K). IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01013767001 7763408 7789751 GO:0046854 phosphoinositide phosphorylation The process of introducing one or more phosphate groups into a phosphoinositide, a class of substances comprising phosphatidylinositol and its derivatives. IEA GO:0005942 phosphoinositide 3-kinase complex A complex containing a heterodimer of a catalytic subunit and a regulatory (adaptor) subunit of any phosphoinositide 3-kinase (PI3K). IEA Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate. IEA GO:0016303 1-phosphatidylinositol-3-kinase activity GSVIVG01013767001 7763408 7789751 GO:0048015 phosphoinositide-mediated signaling A series of molecular signals in which a cell uses a phosphoinositide to convert an extracellular signal into a response. IEA GO:0005942 phosphoinositide 3-kinase complex A complex containing a heterodimer of a catalytic subunit and a regulatory (adaptor) subunit of any phosphoinositide 3-kinase (PI3K). IEA Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate. IEA GO:0016303 1-phosphatidylinositol-3-kinase activity GSVIVG01013767001 7763408 7789751 GO:0046854 phosphoinositide phosphorylation The process of introducing one or more phosphate groups into a phosphoinositide, a class of substances comprising phosphatidylinositol and its derivatives. IEA GO:0005942 phosphoinositide 3-kinase complex A complex containing a heterodimer of a catalytic subunit and a regulatory (adaptor) subunit of any phosphoinositide 3-kinase (PI3K). IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01013767001 7763408 7789751 GO:0048015 phosphoinositide-mediated signaling A series of molecular signals in which a cell uses a phosphoinositide to convert an extracellular signal into a response. IEA GO:0005942 phosphoinositide 3-kinase complex A complex containing a heterodimer of a catalytic subunit and a regulatory (adaptor) subunit of any phosphoinositide 3-kinase (PI3K). IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01029865001 726807 734457 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01028663001 11833980 11834254 GSVIVG01006770001 28296312 28304741 GSVIVG01011352001 28895696 28901148 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and carries out proton transport across a membrane. The proton-transporting domain (F0, V0, or A0) includes integral and peripheral membrane proteins. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01011352001 28895696 28901148 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033179 proton-transporting V-type ATPase, V0 domain A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01028282001 5534622 5535355 GSVIVG01035129001 1690234 1699142 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031795001 4430290 4430939 Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01031795001 4430290 4430939 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01001143001 22983271 23001188 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01033918001 16742046 16747439 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033918001 16742046 16747439 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033918001 16742046 16747439 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033918001 16742046 16747439 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01033918001 16742046 16747439 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01033918001 16742046 16747439 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01033918001 16742046 16747439 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033918001 16742046 16747439 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033918001 16742046 16747439 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033918001 16742046 16747439 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01033918001 16742046 16747439 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01033918001 16742046 16747439 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01033918001 16742046 16747439 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033918001 16742046 16747439 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033918001 16742046 16747439 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021620001 8239436 8272840 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01029271001 17748928 17749621 GSVIVG01032905001 23972119 23975517 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004185 serine-type carboxypeptidase activity GSVIVG01019613001 1947974 1953908 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01019613001 1947974 1953908 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01000914001 21864295 21867415 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000914001 21864295 21867415 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000914001 21864295 21867415 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000914001 21864295 21867415 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01000914001 21864295 21867415 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01000914001 21864295 21867415 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01000914001 21864295 21867415 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01000914001 21864295 21867415 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01000914001 21864295 21867415 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01000914001 21864295 21867415 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01000914001 21864295 21867415 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01000914001 21864295 21867415 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01000914001 21864295 21867415 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01000914001 21864295 21867415 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01000914001 21864295 21867415 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01005023001 17252511 17266794 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA Catalysis of the reaction: protein serine/threonine/tyrosine phosphate + H2O = protein serine/threonine/tyrosine + phosphate. IEA GO:0008138 protein tyrosine/serine/threonine phosphatase activity GSVIVG01005023001 17252511 17266794 GO:0016311 dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. IEA Catalysis of the reaction: protein serine/threonine/tyrosine phosphate + H2O = protein serine/threonine/tyrosine + phosphate. IEA GO:0008138 protein tyrosine/serine/threonine phosphatase activity GSVIVG01005023001 17252511 17266794 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. IEA GO:0016791 phosphatase activity GSVIVG01005023001 17252511 17266794 GO:0016311 dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. IEA Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. IEA GO:0016791 phosphatase activity GSVIVG01008255001 4013614 4030933 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035087001 1371012 1377054 GSVIVG01003719001 7365742 7367472 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01010408001 20268010 20268232 GSVIVG01001657001 14002147 14002275 GSVIVG01020783001 2044341 2046532 GSVIVG01032460001 27641167 27646913 GSVIVG01025752001 12215950 12218080 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025752001 12215950 12218080 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025752001 12215950 12218080 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01025752001 12215950 12218080 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01025752001 12215950 12218080 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025752001 12215950 12218080 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025752001 12215950 12218080 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025752001 12215950 12218080 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033392001 20997638 20999806 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033392001 20997638 20999806 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01029571001 21402004 21407627 GSVIVG01038195001 24266358 24269250 GSVIVG01028583001 10200153 10205567 GSVIVG01004372001 38269872 38270200 GSVIVG01030124001 10055793 10064684 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030124001 10055793 10064684 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030124001 10055793 10064684 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA. IEA GO:0004540 ribonuclease activity GSVIVG01030124001 10055793 10064684 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA. IEA GO:0004540 ribonuclease activity GSVIVG01030124001 10055793 10064684 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01030124001 10055793 10064684 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01030436001 5533596 5535032 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01030436001 5533596 5535032 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029965001 2432731 2436856 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar. IEA GO:0008375 acetylglucosaminyltransferase activity GSVIVG01026448001 23532734 23545014 GSVIVG01014953001 12826742 12829288 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. IEA GO:0004364 glutathione transferase activity GSVIVG01019222001 3126149 3126373 GSVIVG01025652001 13301054 13305442 GO:0008219 cell death A biological process that results in permanent cessation of all vital functions of a cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01036319001 3760302 3760925 GSVIVG01024913001 6084768 6089714 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0019867 outer membrane The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024913001 6084768 6089714 GO:0009405 pathogenesis The set of specific processes that generate the ability of an organism to cause disease in another. IEA GO:0019867 outer membrane The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024913001 6084768 6089714 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0019867 outer membrane The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites. IEA Interacting selectively and non-covalently with cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. IEA GO:0015485 cholesterol binding GSVIVG01024913001 6084768 6089714 GO:0009405 pathogenesis The set of specific processes that generate the ability of an organism to cause disease in another. IEA GO:0019867 outer membrane The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites. IEA Interacting selectively and non-covalently with cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. IEA GO:0015485 cholesterol binding GSVIVG01013184001 6988089 7007000 GSVIVG01032435001 27360731 27370901 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01032435001 27360731 27370901 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01032435001 27360731 27370901 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01032435001 27360731 27370901 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027629001 14895054 14896036 GSVIVG01013434001 505114 509609 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01013434001 505114 509609 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01013434001 505114 509609 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01013434001 505114 509609 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01013434001 505114 509609 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01013434001 505114 509609 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01013434001 505114 509609 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01013434001 505114 509609 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01013434001 505114 509609 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01013434001 505114 509609 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01013434001 505114 509609 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01013434001 505114 509609 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01013434001 505114 509609 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01013434001 505114 509609 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01013434001 505114 509609 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01013434001 505114 509609 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01033105001 25762101 25764241 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01033105001 25762101 25764241 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01023306001 19862400 19885975 GSVIVG01022026001 4155484 4159582 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01022026001 4155484 4159582 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01022026001 4155484 4159582 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01022026001 4155484 4159582 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01035126001 1655452 1664828 GSVIVG01026932001 19316395 19318393 GSVIVG01019092001 16782060 16782353 GSVIVG01000746001 340049 341582 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01000746001 340049 341582 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01032647001 1826382 1836219 GSVIVG01008380001 2681864 2684238 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01016405001 4188017 4188498 GSVIVG01024439001 2545020 2562534 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01024439001 2545020 2562534 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01024439001 2545020 2562534 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01024439001 2545020 2562534 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01024439001 2545020 2562534 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024439001 2545020 2562534 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026693001 4896719 4897425 GSVIVG01009170001 5687068 5688394 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01009170001 5687068 5688394 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01009170001 5687068 5688394 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01023992001 1886320 1890421 GSVIVG01024885001 6240390 6241912 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024885001 6240390 6241912 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024885001 6240390 6241912 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024885001 6240390 6241912 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024885001 6240390 6241912 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024885001 6240390 6241912 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024885001 6240390 6241912 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01024885001 6240390 6241912 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01024885001 6240390 6241912 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01024885001 6240390 6241912 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024885001 6240390 6241912 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024885001 6240390 6241912 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01028027001 3267267 3277999 GO:0000226 microtubule cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. IEA GO:0000922 spindle pole Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules. IEA GSVIVG01028027001 3267267 3277999 GO:0000226 microtubule cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. IEA GO:0005815 microtubule organizing center A cytoplasmic structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides. IEA GSVIVG01031160001 1603687 1615727 GSVIVG01027148001 17414748 17419237 GSVIVG01008301001 3462740 3465475 GSVIVG01028104001 3841351 3845412 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01003200001 7802638 7805617 GSVIVG01030420001 5441210 5442777 GSVIVG01009442001 8406079 8407688 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01027122001 17645535 17647763 GO:0006548 histidine catabolic process The chemical reactions and pathways resulting in the breakdown of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. IEA Catalysis of the reaction: 3,4-dihydroxyphenethylamine + ascorbate + O2 = noradrenaline + dehydroascorbate + H2O. IEA GO:0004500 dopamine beta-monooxygenase activity GSVIVG01012709001 866241 871411 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01012709001 866241 871411 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021798001 7248697 7252898 GSVIVG01032790001 757786 761496 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01032512001 27998622 28005330 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032512001 27998622 28005330 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01032512001 27998622 28005330 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032512001 27998622 28005330 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0008236 serine-type peptidase activity GSVIVG01007072001 30043223 30044473 Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester. IEA GO:0005543 phospholipid binding GSVIVG01012062001 1709972 1715657 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004185 serine-type carboxypeptidase activity GSVIVG01038545001 22015153 22015892 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with manganese (Mn) ions. IEA GO:0030145 manganese ion binding GSVIVG01038545001 22015153 22015892 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Functions in the storage of nutritious substrates. IEA GO:0045735 nutrient reservoir activity GSVIVG01035778001 4215069 4225087 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035778001 4215069 4225087 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. IEA GO:0004722 protein serine/threonine phosphatase activity GSVIVG01010031001 13662478 13665624 GSVIVG01030295001 9337016 9340390 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01030295001 9337016 9340390 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01030295001 9337016 9340390 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01030295001 9337016 9340390 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01008279001 3690417 3693662 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA GSVIVG01020464001 19016466 19020315 GSVIVG01026766001 6612448 6718937 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008773001 1825416 1828541 GSVIVG01027603001 15128128 15130494 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027603001 15128128 15130494 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027603001 15128128 15130494 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027603001 15128128 15130494 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027603001 15128128 15130494 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01027603001 15128128 15130494 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01000157001 15733291 15736152 GSVIVG01003551001 14553614 14555837 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019903001 4365045 4369553 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01020975001 16054733 16054918 GSVIVG01003767001 12507644 12510939 GSVIVG01024328001 1009622 1036174 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01031213001 1129570 1135804 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01031213001 1129570 1135804 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01031213001 1129570 1135804 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031213001 1129570 1135804 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01029920001 1488807 1498737 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01029920001 1488807 1498737 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01029920001 1488807 1498737 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01029920001 1488807 1498737 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01029920001 1488807 1498737 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01029920001 1488807 1498737 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01029920001 1488807 1498737 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01029920001 1488807 1498737 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01029920001 1488807 1498737 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01000196001 16026061 16030244 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01000196001 16026061 16030244 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01000196001 16026061 16030244 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01000196001 16026061 16030244 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01021357001 4420780 4421895 GSVIVG01037422001 14014094 14035182 GO:0007034 vacuolar transport The directed movement of substances into, out of or within a vacuole. IEA GO:0030904 retromer complex A conserved multimeric membrane-associated complex involved in retrograde transport from endosomes to the Golgi apparatus. For example, the budding yeast retromer comprises Vps35p, Vps29p, Vps26p, Vps5p, and Vps17p. IEA GSVIVG01023741001 10424011 10449443 GSVIVG01009510001 8963588 8967926 GSVIVG01021385001 4777303 4781241 GSVIVG01038155001 23940488 23942419 GSVIVG01021528001 6666048 6669048 GSVIVG01020193001 9207773 9208125 GSVIVG01037295001 16322877 16325979 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01037295001 16322877 16325979 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01037295001 16322877 16325979 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01037295001 16322877 16325979 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01037295001 16322877 16325979 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01037295001 16322877 16325979 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01037295001 16322877 16325979 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Catalysis of the reaction: 4 ATP + 2 phosphorylase b = 4 ADP + phosphorylase a. IEA GO:0004689 phosphorylase kinase activity GSVIVG01037295001 16322877 16325979 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Catalysis of the reaction: 4 ATP + 2 phosphorylase b = 4 ADP + phosphorylase a. IEA GO:0004689 phosphorylase kinase activity GSVIVG01037295001 16322877 16325979 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01037295001 16322877 16325979 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01037295001 16322877 16325979 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01037295001 16322877 16325979 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01037295001 16322877 16325979 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01037295001 16322877 16325979 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01037295001 16322877 16325979 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. IEA GO:0005516 calmodulin binding GSVIVG01037295001 16322877 16325979 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. IEA GO:0005516 calmodulin binding GSVIVG01037295001 16322877 16325979 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037295001 16322877 16325979 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028895001 17730595 17735820 GSVIVG01024485001 3173593 3181281 GSVIVG01033251001 22183311 22186065 GSVIVG01024856001 6434776 6460996 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01024856001 6434776 6460996 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01024856001 6434776 6460996 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01024856001 6434776 6460996 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01028045001 3415272 3429714 GO:0015969 guanosine tetraphosphate metabolic process The chemical reactions and pathways involving guanine tetraphosphate (5'-ppGpp-3'), a derivative of guanine riboside with four phosphates. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01020650001 3448145 3455359 GO:0006631 fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor. IEA GO:0003995 acyl-CoA dehydrogenase activity GSVIVG01020650001 3448145 3455359 GO:0006635 fatty acid beta-oxidation A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor. IEA GO:0003995 acyl-CoA dehydrogenase activity GSVIVG01020650001 3448145 3455359 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor. IEA GO:0003995 acyl-CoA dehydrogenase activity GSVIVG01020650001 3448145 3455359 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor. IEA GO:0003995 acyl-CoA dehydrogenase activity GSVIVG01020650001 3448145 3455359 GO:0006631 fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Catalysis of the reaction: acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2. IEA GO:0003997 acyl-CoA oxidase activity GSVIVG01020650001 3448145 3455359 GO:0006635 fatty acid beta-oxidation A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Catalysis of the reaction: acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2. IEA GO:0003997 acyl-CoA oxidase activity GSVIVG01020650001 3448145 3455359 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Catalysis of the reaction: acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2. IEA GO:0003997 acyl-CoA oxidase activity GSVIVG01020650001 3448145 3455359 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Catalysis of the reaction: acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2. IEA GO:0003997 acyl-CoA oxidase activity GSVIVG01020650001 3448145 3455359 GO:0006631 fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01020650001 3448145 3455359 GO:0006635 fatty acid beta-oxidation A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01020650001 3448145 3455359 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01020650001 3448145 3455359 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01020650001 3448145 3455359 GO:0006631 fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GSVIVG01020650001 3448145 3455359 GO:0006635 fatty acid beta-oxidation A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GSVIVG01020650001 3448145 3455359 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GSVIVG01020650001 3448145 3455359 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GSVIVG01020650001 3448145 3455359 GO:0006631 fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01020650001 3448145 3455359 GO:0006635 fatty acid beta-oxidation A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01020650001 3448145 3455359 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01020650001 3448145 3455359 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01002072001 32703364 32706432 GSVIVG01032608001 28799932 28800051 GSVIVG01028150001 4219849 4224045 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01028150001 4219849 4224045 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008958001 3845616 3852022 GSVIVG01030947001 19590669 19591197 Interacting selectively and non-covalently with thiamin pyrophosphate, the diphosphoric ester of thiamin. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases. IEA GO:0030976 thiamin pyrophosphate binding GSVIVG01008352001 3007995 3020353 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01008352001 3007995 3020353 GO:0031123 RNA 3'-end processing Any process involved in forming the mature 3' end of an RNA molecule. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01008352001 3007995 3020353 GO:0043631 RNA polyadenylation The enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01008352001 3007995 3020353 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the template-independent extension of the 3'- end of an RNA or DNA strand by addition of one adenosine molecule at a time. Cannot initiate a chain 'de novo'. The primer, depending on the source of the enzyme, may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group. IEA GO:0004652 polynucleotide adenylyltransferase activity GSVIVG01008352001 3007995 3020353 GO:0031123 RNA 3'-end processing Any process involved in forming the mature 3' end of an RNA molecule. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the template-independent extension of the 3'- end of an RNA or DNA strand by addition of one adenosine molecule at a time. Cannot initiate a chain 'de novo'. The primer, depending on the source of the enzyme, may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group. IEA GO:0004652 polynucleotide adenylyltransferase activity GSVIVG01008352001 3007995 3020353 GO:0043631 RNA polyadenylation The enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the template-independent extension of the 3'- end of an RNA or DNA strand by addition of one adenosine molecule at a time. Cannot initiate a chain 'de novo'. The primer, depending on the source of the enzyme, may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group. IEA GO:0004652 polynucleotide adenylyltransferase activity GSVIVG01008352001 3007995 3020353 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the transfer of a nucleotidyl group to a reactant. IEA GO:0016779 nucleotidyltransferase activity GSVIVG01008352001 3007995 3020353 GO:0031123 RNA 3'-end processing Any process involved in forming the mature 3' end of an RNA molecule. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the transfer of a nucleotidyl group to a reactant. IEA GO:0016779 nucleotidyltransferase activity GSVIVG01008352001 3007995 3020353 GO:0043631 RNA polyadenylation The enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the transfer of a nucleotidyl group to a reactant. IEA GO:0016779 nucleotidyltransferase activity GSVIVG01001958001 16133519 16143123 GSVIVG01017904001 4510252 4514346 GSVIVG01016630001 2339470 2340544 GSVIVG01023025001 16746394 16753293 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023025001 16746394 16753293 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023025001 16746394 16753293 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023025001 16746394 16753293 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023025001 16746394 16753293 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01023025001 16746394 16753293 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01023025001 16746394 16753293 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01023025001 16746394 16753293 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01023025001 16746394 16753293 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023025001 16746394 16753293 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023025001 16746394 16753293 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023025001 16746394 16753293 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023025001 16746394 16753293 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023025001 16746394 16753293 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023025001 16746394 16753293 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023025001 16746394 16753293 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023025001 16746394 16753293 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01023025001 16746394 16753293 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01023025001 16746394 16753293 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01023025001 16746394 16753293 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01029491001 22300742 22304084 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029491001 22300742 22304084 Catalysis of the transfer of a functional group from one position to another within a single molecule. IEA GO:0016866 intramolecular transferase activity GSVIVG01006297001 24724184 24725578 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01006297001 24724184 24725578 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01006297001 24724184 24725578 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006297001 24724184 24725578 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01014216001 1566160 1570486 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01037332001 15569832 15572513 GSVIVG01011600001 6076528 6083280 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01011600001 6076528 6083280 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. IEA GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GSVIVG01011600001 6076528 6083280 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species. IEA GO:0031418 L-ascorbic acid binding GSVIVG01016804001 1537562 1542931 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GSVIVG01036509001 22839609 22840354 GSVIVG01036629001 19384494 19385699 GSVIVG01031295001 574486 580116 GO:0006006 glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031295001 574486 580116 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031295001 574486 580116 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031295001 574486 580116 GO:0006006 glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. IEA Catalysis of the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+. IEA GO:0004345 glucose-6-phosphate dehydrogenase activity GSVIVG01031295001 574486 580116 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+. IEA GO:0004345 glucose-6-phosphate dehydrogenase activity GSVIVG01031295001 574486 580116 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+. IEA GO:0004345 glucose-6-phosphate dehydrogenase activity GSVIVG01031295001 574486 580116 GO:0006006 glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031295001 574486 580116 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031295001 574486 580116 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01001459001 21165362 21170850 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01037551001 11572429 11572903 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01037551001 11572429 11572903 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01020722001 2678657 2693002 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01020722001 2678657 2693002 Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01031115001 2048575 2053655 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031115001 2048575 2053655 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01029663001 12665012 12672691 GSVIVG01026714001 5331702 5332001 GSVIVG01011070001 1821478 1830545 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01011070001 1821478 1830545 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01009828001 11600520 11607671 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01009828001 11600520 11607671 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020687001 3103958 3105784 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020687001 3103958 3105784 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020687001 3103958 3105784 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01020687001 3103958 3105784 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01000105001 15309043 15319149 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01000757001 446060 449091 GSVIVG01011903001 3141923 3143013 GSVIVG01013510001 2014564 2016247 GSVIVG01021149001 1849793 1851899 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01028113001 3901920 3906466 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01028113001 3901920 3906466 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01028113001 3901920 3906466 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01028113001 3901920 3906466 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01028113001 3901920 3906466 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01028113001 3901920 3906466 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01028113001 3901920 3906466 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01028113001 3901920 3906466 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01028113001 3901920 3906466 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01028113001 3901920 3906466 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01028113001 3901920 3906466 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01028113001 3901920 3906466 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01028113001 3901920 3906466 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01028113001 3901920 3906466 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01028113001 3901920 3906466 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01028113001 3901920 3906466 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01028113001 3901920 3906466 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01028113001 3901920 3906466 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01028113001 3901920 3906466 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01028113001 3901920 3906466 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01028113001 3901920 3906466 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028113001 3901920 3906466 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028113001 3901920 3906466 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028113001 3901920 3906466 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028113001 3901920 3906466 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028113001 3901920 3906466 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01028113001 3901920 3906466 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01028113001 3901920 3906466 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01028113001 3901920 3906466 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01028113001 3901920 3906466 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01035889001 5352256 5356095 GSVIVG01003859001 12949029 12959785 GO:0006544 glycine metabolic process The chemical reactions and pathways involving glycine, aminoethanoic acid. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003859001 12949029 12959785 GO:0006563 L-serine metabolic process The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003859001 12949029 12959785 GO:0006544 glycine metabolic process The chemical reactions and pathways involving glycine, aminoethanoic acid. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine. IEA GO:0004372 glycine hydroxymethyltransferase activity GSVIVG01003859001 12949029 12959785 GO:0006563 L-serine metabolic process The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine. IEA GO:0004372 glycine hydroxymethyltransferase activity GSVIVG01003859001 12949029 12959785 GO:0006544 glycine metabolic process The chemical reactions and pathways involving glycine, aminoethanoic acid. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01003859001 12949029 12959785 GO:0006563 L-serine metabolic process The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01036964001 9454987 9459930 GSVIVG01026038001 25439221 25439608 Interacting selectively and non-covalently with oxygen (O2). IEA GO:0019825 oxygen binding GSVIVG01026038001 25439221 25439608 Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01025283001 2444520 2451760 GSVIVG01009085001 4859566 4894817 GSVIVG01019972001 12165162 12169309 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01019972001 12165162 12169309 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01033254001 22158579 22159872 GSVIVG01026659001 20632567 20634565 GSVIVG01018802001 19732143 19742086 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01018802001 19732143 19742086 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01026343001 14434731 14448837 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01026343001 14434731 14448837 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01026088001 24717585 24778463 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01012608001 4605909 4606049 GSVIVG01019470001 894591 895747 GSVIVG01031673001 19967432 19975143 GSVIVG01001842001 26240274 26242794 GO:0006006 glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001842001 26240274 26242794 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001842001 26240274 26242794 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001842001 26240274 26242794 GO:0006006 glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. IEA Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+. IEA GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity GSVIVG01001842001 26240274 26242794 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+. IEA GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity GSVIVG01001842001 26240274 26242794 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+. IEA GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity GSVIVG01001842001 26240274 26242794 GO:0006006 glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01001842001 26240274 26242794 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01001842001 26240274 26242794 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01001842001 26240274 26242794 GO:0006006 glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. IEA Catalysis of the reaction: glyceraldehyde 3-phosphate + (phosphate / H2O) + NAD(P)+ = (3-phospho-D-glyceroyl-phosphate / 3-phospho-D-glycerate) + NAD(P)H + H+. IEA GO:0008943 glyceraldehyde-3-phosphate dehydrogenase activity GSVIVG01001842001 26240274 26242794 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: glyceraldehyde 3-phosphate + (phosphate / H2O) + NAD(P)+ = (3-phospho-D-glyceroyl-phosphate / 3-phospho-D-glycerate) + NAD(P)H + H+. IEA GO:0008943 glyceraldehyde-3-phosphate dehydrogenase activity GSVIVG01001842001 26240274 26242794 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: glyceraldehyde 3-phosphate + (phosphate / H2O) + NAD(P)+ = (3-phospho-D-glyceroyl-phosphate / 3-phospho-D-glycerate) + NAD(P)H + H+. IEA GO:0008943 glyceraldehyde-3-phosphate dehydrogenase activity GSVIVG01001842001 26240274 26242794 GO:0006006 glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01001842001 26240274 26242794 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01001842001 26240274 26242794 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01037034001 8696026 8697570 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01037034001 8696026 8697570 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01016342001 4787337 4792768 GSVIVG01017603001 1938563 1950410 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01017603001 1938563 1950410 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01017603001 1938563 1950410 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033745001 18178271 18183452 GSVIVG01003659001 11857655 11863005 The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01010184001 16927370 16938407 GSVIVG01027439001 16704518 16708180 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0043231 intracellular membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. IEA Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2. IEA GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity GSVIVG01027439001 16704518 16708180 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0043231 intracellular membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. IEA Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2. IEA GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity GSVIVG01027439001 16704518 16708180 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0043231 intracellular membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. IEA Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2. IEA GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity GSVIVG01027439001 16704518 16708180 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0043231 intracellular membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. IEA Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide. IEA GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor GSVIVG01027439001 16704518 16708180 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0043231 intracellular membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. IEA Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide. IEA GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor GSVIVG01027439001 16704518 16708180 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0043231 intracellular membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. IEA Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide. IEA GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor GSVIVG01014796001 9888025 9894086 GO:0016459 myosin complex A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. IEA Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate. IEA GO:0003774 motor activity GSVIVG01014796001 9888025 9894086 GO:0016459 myosin complex A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029463001 22560444 22560719 GSVIVG01022048001 3775957 3784286 The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01023810001 3303133 3306036 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023810001 3303133 3306036 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023810001 3303133 3306036 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01017754001 3160876 3165959 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029044001 11311929 11315630 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01029044001 11311929 11315630 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01029044001 11311929 11315630 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01029044001 11311929 11315630 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029044001 11311929 11315630 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033157001 8622023 8624152 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033157001 8622023 8624152 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033157001 8622023 8624152 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033157001 8622023 8624152 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033157001 8622023 8624152 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01033157001 8622023 8624152 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01025290001 2404345 2409440 GSVIVG01036507001 22800002 22802319 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01019699001 2549060 2551460 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019932001 4563884 4565588 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019932001 4563884 4565588 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012019001 2145560 2145874 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012019001 2145560 2145874 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01002733001 36252652 36254885 GSVIVG01035790001 4366917 4370044 Interacting selectively and non-covalently with single-stranded DNA. IEA GO:0003697 single-stranded DNA binding GSVIVG01035790001 4366917 4370044 Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01029445001 22831243 22832073 GSVIVG01004114001 14974902 14976097 GSVIVG01017307001 6564403 6567208 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01010739001 21973654 21975210 GSVIVG01032578001 28532840 28538792 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01032578001 28532840 28538792 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01032578001 28532840 28538792 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032578001 28532840 28538792 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032578001 28532840 28538792 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01032578001 28532840 28538792 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01032578001 28532840 28538792 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01032578001 28532840 28538792 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01032578001 28532840 28538792 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01032578001 28532840 28538792 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01028468001 8027470 8028053 GSVIVG01027441001 16697939 16699348 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01027441001 16697939 16699348 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01001533001 1095640 1103459 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01022412001 19853167 19855359 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01022412001 19853167 19855359 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024574001 8688342 8694401 GO:0009405 pathogenesis The set of specific processes that generate the ability of an organism to cause disease in another. IEA GO:0009289 pilus A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter. IEA GSVIVG01024574001 8688342 8694401 GO:0009405 pathogenesis The set of specific processes that generate the ability of an organism to cause disease in another. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01024574001 8688342 8694401 GO:0009405 pathogenesis The set of specific processes that generate the ability of an organism to cause disease in another. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01031705001 3591023 3593043 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01031705001 3591023 3593043 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01031705001 3591023 3593043 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01037300001 16266089 16267284 Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01037300001 16266089 16267284 Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01037300001 16266089 16267284 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01037300001 16266089 16267284 Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01028789001 18791603 18798648 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01008597001 546420 548495 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0008076 voltage-gated potassium channel complex A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01008597001 546420 548495 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01034975001 602815 610049 GSVIVG01018163001 13735905 13737759 GO:0009664 plant-type cell wall organization A process that results in the assembly and arrangement of constituent parts of the cellulose and pectin-containing cell wall, or in the disassembly of the cellulose and pectin-containing cell wall. This process is carried out at the cellular level. An example of this process is found in Arabidopsis thaliana. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA GSVIVG01018163001 13735905 13737759 GO:0019953 sexual reproduction The regular alternation, in the life cycle of haplontic, diplontic and diplohaplontic organisms, of meiosis and fertilization which provides for the production offspring. In diplontic organisms there is a life cycle in which the products of meiosis behave directly as gametes, fusing to form a zygote from which the diploid, or sexually reproductive polyploid, adult organism will develop. In diplohaplontic organisms a haploid phase (gametophyte) exists in the life cycle between meiosis and fertilization (e.g. higher plants, many algae and Fungi); the products of meiosis are spores that develop as haploid individuals from which haploid gametes develop to form a diploid zygote; diplohaplontic organisms show an alternation of haploid and diploid generations. In haplontic organisms meiosis occurs in the zygote, giving rise to four haploid cells (e.g. many algae and protozoa), only the zygote is diploid and this may form a resistant spore, tiding organisms over hard times. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA GSVIVG01030080001 9653486 9656767 GSVIVG01003713001 15112641 15115779 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01003713001 15112641 15115779 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01016970001 3057632 3057903 GSVIVG01012343001 549198 552047 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01012343001 549198 552047 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01012343001 549198 552047 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01012343001 549198 552047 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01012343001 549198 552047 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01012343001 549198 552047 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01012343001 549198 552047 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01012343001 549198 552047 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01001045001 6922239 7007216 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01001045001 6922239 7007216 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01001045001 6922239 7007216 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01001045001 6922239 7007216 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with double-stranded RNA. IEA GO:0003725 double-stranded RNA binding GSVIVG01001045001 6922239 7007216 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01001045001 6922239 7007216 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt. IEA GO:0004525 ribonuclease III activity GSVIVG01001045001 6922239 7007216 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001045001 6922239 7007216 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01001045001 6922239 7007216 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01015214001 1874968 1881825 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GSVIVG01011112001 1479520 1482628 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01020309001 21590128 21600084 GSVIVG01033098001 25693147 25704407 GSVIVG01030538001 6572624 6578050 GO:0006198 cAMP catabolic process The chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). IEA Catalysis of the reaction: adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate. IEA GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity GSVIVG01001843001 26243797 26261925 GSVIVG01016016001 17380453 17395619 GSVIVG01025385001 1190069 1199291 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025385001 1190069 1199291 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01025385001 1190069 1199291 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01025385001 1190069 1199291 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014688001 8637608 8659887 GO:0006342 chromatin silencing Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01014688001 8637608 8659887 GO:0006476 protein amino acid deacetylation The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01014688001 8637608 8659887 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01014688001 8637608 8659887 GO:0006342 chromatin silencing Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin. IEA Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide. IEA GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides GSVIVG01014688001 8637608 8659887 GO:0006476 protein amino acid deacetylation The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid. IEA Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide. IEA GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides GSVIVG01014688001 8637608 8659887 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide. IEA GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides GSVIVG01014688001 8637608 8659887 GO:0006342 chromatin silencing Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin. IEA Interacting selectively and non-covalently with the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions. IEA GO:0070403 NAD binding GSVIVG01014688001 8637608 8659887 GO:0006476 protein amino acid deacetylation The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid. IEA Interacting selectively and non-covalently with the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions. IEA GO:0070403 NAD binding GSVIVG01014688001 8637608 8659887 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions. IEA GO:0070403 NAD binding GSVIVG01000412001 7671647 7672802 GSVIVG01038671001 21086511 21089370 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01038671001 21086511 21089370 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01038671001 21086511 21089370 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01038671001 21086511 21089370 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01038671001 21086511 21089370 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024400001 2123299 2128332 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01013456001 314471 315046 GSVIVG01014195001 1375241 1379055 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. IEA GO:0004969 histamine receptor activity GSVIVG01033250001 22202178 22202414 GSVIVG01032389001 26886951 26893203 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01032389001 26886951 26893203 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01032389001 26886951 26893203 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01032389001 26886951 26893203 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007878001 8011743 8034743 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01007878001 8011743 8034743 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01007878001 8011743 8034743 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01007878001 8011743 8034743 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01007878001 8011743 8034743 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01007878001 8011743 8034743 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01036480001 22557923 22560946 GSVIVG01024941001 5873970 5875430 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01008878001 3057416 3063993 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01008878001 3057416 3063993 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01006970001 29479776 29486629 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01006970001 29479776 29486629 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01006970001 29479776 29486629 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01006970001 29479776 29486629 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01013092001 8381119 8408777 GSVIVG01016112001 19158477 19159781 Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum. IEA GO:0003993 acid phosphatase activity GSVIVG01028909001 17636565 17646586 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01028909001 17636565 17646586 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01028909001 17636565 17646586 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01028909001 17636565 17646586 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01028909001 17636565 17646586 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01028909001 17636565 17646586 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01028909001 17636565 17646586 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01028909001 17636565 17646586 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01028909001 17636565 17646586 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01028909001 17636565 17646586 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01028909001 17636565 17646586 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01028909001 17636565 17646586 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01028909001 17636565 17646586 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028909001 17636565 17646586 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028909001 17636565 17646586 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015172001 1547073 1557693 GSVIVG01007787001 9007209 9010760 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01036705001 23540099 23540654 GSVIVG01018463001 14717774 14720495 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01010323001 19493536 19497183 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01010323001 19493536 19497183 Catalysis of the hydrolysis of ester linkages within nucleic acids. IEA GO:0004518 nuclease activity GSVIVG01023783001 3488694 3491726 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01001462001 21191277 21193773 GSVIVG01032305001 14802396 14802764 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA GSVIVG01032305001 14802396 14802764 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA GSVIVG01031949001 5622687 5623342 GSVIVG01001514001 5426131 5426661 GSVIVG01010783001 22549436 22551788 GSVIVG01038106001 23524735 23526631 GSVIVG01023087001 15489349 15494349 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01002581001 35291385 35294557 GSVIVG01023484001 11115541 11117161 GSVIVG01024604001 8499442 8505462 GO:0001522 pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01024604001 8499442 8505462 GO:0009451 RNA modification The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01024604001 8499442 8505462 GO:0001522 pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs. IEA Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. IEA GO:0009982 pseudouridine synthase activity GSVIVG01024604001 8499442 8505462 GO:0009451 RNA modification The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. IEA Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. IEA GO:0009982 pseudouridine synthase activity GSVIVG01014350001 2924506 2929619 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01014350001 2924506 2929619 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01014350001 2924506 2929619 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01014350001 2924506 2929619 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01014350001 2924506 2929619 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01014350001 2924506 2929619 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01014350001 2924506 2929619 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01014350001 2924506 2929619 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01014350001 2924506 2929619 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01014350001 2924506 2929619 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01014350001 2924506 2929619 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01014350001 2924506 2929619 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01014350001 2924506 2929619 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces an oxygen molecule. IEA GO:0050664 oxidoreductase activity, acting on NADH or NADPH, with oxygen as acceptor GSVIVG01014350001 2924506 2929619 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces an oxygen molecule. IEA GO:0050664 oxidoreductase activity, acting on NADH or NADPH, with oxygen as acceptor GSVIVG01019447001 753241 756161 GSVIVG01022828001 18989779 19000861 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030405001 5298228 5310993 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01030405001 5298228 5310993 GO:0006268 DNA unwinding involved in replication The process by which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01030405001 5298228 5310993 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle. IEA GO:0003917 DNA topoisomerase type I activity GSVIVG01030405001 5298228 5310993 GO:0006268 DNA unwinding involved in replication The process by which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle. IEA GO:0003917 DNA topoisomerase type I activity GSVIVG01030405001 5298228 5310993 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. IEA GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity GSVIVG01030405001 5298228 5310993 GO:0006268 DNA unwinding involved in replication The process by which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. IEA GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity GSVIVG01034938001 249313 251248 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01038125001 23661931 23675612 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01038125001 23661931 23675612 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01038125001 23661931 23675612 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA GO:0008061 chitin binding GSVIVG01038125001 23661931 23675612 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA GO:0008061 chitin binding GSVIVG01021121001 1637127 1642496 GSVIVG01020432001 19529948 19532156 GSVIVG01015890001 18984927 18985470 GSVIVG01023718001 9952549 9955089 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01023718001 9952549 9955089 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01023718001 9952549 9955089 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01023718001 9952549 9955089 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01023718001 9952549 9955089 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01023718001 9952549 9955089 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01037412001 14201634 14201870 GSVIVG01010013001 13446199 13457203 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function that links a sequence-specific transcription factor to the core RNA polymerase II complex but does not bind DNA itself. IEA GO:0003712 transcription cofactor activity GSVIVG01026029001 25580849 25581262 GSVIVG01035807001 4539835 4544615 GSVIVG01031953001 5657469 5670765 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01031953001 5657469 5670765 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01031953001 5657469 5670765 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01031953001 5657469 5670765 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01031953001 5657469 5670765 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01031953001 5657469 5670765 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01031953001 5657469 5670765 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01031953001 5657469 5670765 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01031953001 5657469 5670765 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01031953001 5657469 5670765 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01031953001 5657469 5670765 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031953001 5657469 5670765 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031953001 5657469 5670765 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031953001 5657469 5670765 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031953001 5657469 5670765 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031953001 5657469 5670765 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01031953001 5657469 5670765 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01031953001 5657469 5670765 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01031953001 5657469 5670765 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01031953001 5657469 5670765 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01003018001 37526060 37530348 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01005067001 17861322 17864023 GSVIVG01017368001 7437811 7445837 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01000363001 33557 34552 GSVIVG01004309001 38017587 38018495 GSVIVG01025267001 2586775 2592261 GSVIVG01030213001 10381813 10385443 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01030213001 10381813 10385443 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01030213001 10381813 10385443 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01030213001 10381813 10385443 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01030213001 10381813 10385443 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01030213001 10381813 10385443 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01030213001 10381813 10385443 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030213001 10381813 10385443 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019797001 3392461 3394348 GSVIVG01013688001 2645631 2665321 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01013688001 2645631 2665321 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01023017001 16845301 16855616 GSVIVG01027968001 2875362 2879017 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027968001 2875362 2879017 GO:0009396 folic acid and derivative biosynthetic process The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027968001 2875362 2879017 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027968001 2875362 2879017 GO:0009396 folic acid and derivative biosynthetic process The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027002001 18650540 18655050 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01027002001 18650540 18655050 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01027002001 18650540 18655050 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01000831001 2662086 2674047 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01020625001 3670583 3671931 Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. IEA GO:0008171 O-methyltransferase activity GSVIVG01034698001 7957530 7958491 GSVIVG01005028001 17308971 17312121 GO:0032312 regulation of ARF GTPase activity Any process that modulates the activity of the GTPase ARF. IEA Increases the rate of GTP hydrolysis by the GTPase ARF. IEA GO:0008060 ARF GTPase activator activity GSVIVG01005028001 17308971 17312121 GO:0032312 regulation of ARF GTPase activity Any process that modulates the activity of the GTPase ARF. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01024390001 2000497 2001135 GSVIVG01010757001 22224036 22226366 GSVIVG01034433001 16281420 16283059 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034433001 16281420 16283059 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036495001 22672406 22675890 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01036495001 22672406 22675890 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01036495001 22672406 22675890 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01036495001 22672406 22675890 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036495001 22672406 22675890 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016535001 3017895 3032580 GSVIVG01034033001 15693328 15695935 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01003622001 379876 380519 GSVIVG01035785001 4265752 4286094 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01035785001 4265752 4286094 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035785001 4265752 4286094 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01035785001 4265752 4286094 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01015849001 18336898 18341110 GSVIVG01012668001 477275 487964 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01012668001 477275 487964 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01012668001 477275 487964 GO:0006429 leucyl-tRNA aminoacylation The process of coupling leucine to leucyl-tRNA, catalyzed by leucyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01012668001 477275 487964 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01012668001 477275 487964 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01012668001 477275 487964 GO:0006429 leucyl-tRNA aminoacylation The process of coupling leucine to leucyl-tRNA, catalyzed by leucyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01012668001 477275 487964 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). IEA GO:0004823 leucine-tRNA ligase activity GSVIVG01012668001 477275 487964 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). IEA GO:0004823 leucine-tRNA ligase activity GSVIVG01012668001 477275 487964 GO:0006429 leucyl-tRNA aminoacylation The process of coupling leucine to leucyl-tRNA, catalyzed by leucyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). IEA GO:0004823 leucine-tRNA ligase activity GSVIVG01012668001 477275 487964 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012668001 477275 487964 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012668001 477275 487964 GO:0006429 leucyl-tRNA aminoacylation The process of coupling leucine to leucyl-tRNA, catalyzed by leucyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012668001 477275 487964 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01012668001 477275 487964 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01012668001 477275 487964 GO:0006429 leucyl-tRNA aminoacylation The process of coupling leucine to leucyl-tRNA, catalyzed by leucyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01015604001 5526233 5536190 GSVIVG01004105001 14856467 14860814 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01004105001 14856467 14860814 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01004105001 14856467 14860814 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01004105001 14856467 14860814 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01004105001 14856467 14860814 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01004105001 14856467 14860814 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01038286001 24978596 24980036 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01038286001 24978596 24980036 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. IEA GO:0004519 endonuclease activity GSVIVG01038286001 24978596 24980036 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01038286001 24978596 24980036 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051539 4 iron, 4 sulfur cluster binding GSVIVG01009945001 12699750 12707465 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01009945001 12699750 12707465 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01009945001 12699750 12707465 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01030626001 7267087 7268417 GSVIVG01010782001 22545646 22549350 GSVIVG01009403001 8020849 8029561 GSVIVG01024079001 1286455 1288521 GSVIVG01018472001 14592615 14594741 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01018472001 14592615 14594741 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01018472001 14592615 14594741 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01018472001 14592615 14594741 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01003324001 9053890 9062846 GSVIVG01033276001 21942957 21949047 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule. IEA GO:0000175 3'-5'-exoribonuclease activity GSVIVG01033276001 21942957 21949047 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01030881001 18305205 18309167 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030881001 18305205 18309167 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01030881001 18305205 18309167 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01008299001 3477176 3478644 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01031454001 18333291 18334809 GO:0007049 cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. IEA Modulates the activity of a cyclin-dependent protein kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins. IEA GO:0016538 cyclin-dependent protein kinase regulator activity GSVIVG01023839001 3061225 3067402 GO:0016575 histone deacetylation The modification of histones by removal of acetyl groups. IEA Catalysis of the hydrolysis of acetyl groups from histones, proteins complexed to DNA in chromatin and chromosomes. IEA GO:0004407 histone deacetylase activity GSVIVG01028606001 10631431 10632828 GO:0009405 pathogenesis The set of specific processes that generate the ability of an organism to cause disease in another. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA GSVIVG01016917001 2542746 2549085 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01016917001 2542746 2549085 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01016917001 2542746 2549085 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01016917001 2542746 2549085 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016917001 2542746 2549085 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021525001 6611406 6637282 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021525001 6611406 6637282 Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. IEA GO:0008483 transaminase activity GSVIVG01021525001 6611406 6637282 Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01021525001 6611406 6637282 Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01025895001 27419481 27419627 GSVIVG01000549001 7217134 7229969 GSVIVG01004789001 16138226 16141612 GSVIVG01006376001 25357331 25358057 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01006376001 25357331 25358057 Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium. IEA GO:0005544 calcium-dependent phospholipid binding GSVIVG01009267001 6826940 6830995 GSVIVG01010913001 15800592 15802071 GO:0006644 phospholipid metabolic process The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester. IEA Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. IEA GO:0004623 phospholipase A2 activity GSVIVG01010913001 15800592 15802071 GO:0016042 lipid catabolic process The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. IEA GO:0004623 phospholipase A2 activity GSVIVG01010913001 15800592 15802071 GO:0006644 phospholipid metabolic process The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01010913001 15800592 15802071 GO:0016042 lipid catabolic process The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01011918001 3014282 3016379 GSVIVG01017381001 7604699 7616138 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01005123001 18364059 18372404 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01005123001 18364059 18372404 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01005123001 18364059 18372404 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01005123001 18364059 18372404 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01005123001 18364059 18372404 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA The action of a molecule that contributes to the structural integrity of a cell wall. IEA GO:0005199 structural constituent of cell wall GSVIVG01005123001 18364059 18372404 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The action of a molecule that contributes to the structural integrity of a cell wall. IEA GO:0005199 structural constituent of cell wall GSVIVG01005123001 18364059 18372404 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA The action of a molecule that contributes to the structural integrity of a cell wall. IEA GO:0005199 structural constituent of cell wall GSVIVG01005123001 18364059 18372404 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The action of a molecule that contributes to the structural integrity of a cell wall. IEA GO:0005199 structural constituent of cell wall GSVIVG01005123001 18364059 18372404 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01005123001 18364059 18372404 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01005123001 18364059 18372404 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01005123001 18364059 18372404 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01031048001 21433386 21444467 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with damaged DNA. IEA GO:0003684 damaged DNA binding GSVIVG01031048001 21433386 21444467 GO:0043161 proteasomal ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with damaged DNA. IEA GO:0003684 damaged DNA binding GSVIVG01024325001 898830 955444 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005664 nuclear origin of replication recognition complex A multisubunit complex that is located at the replication origins of a chromosome in the nucleus. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01008372001 2724698 2742734 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01008372001 2724698 2742734 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01008372001 2724698 2742734 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01008372001 2724698 2742734 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000078001 3274893 3275600 GSVIVG01031853001 4887975 4921315 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01028438001 7509267 7518326 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028438001 7509267 7518326 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028438001 7509267 7518326 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028438001 7509267 7518326 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028438001 7509267 7518326 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01028438001 7509267 7518326 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01022448001 3140699 3142633 GSVIVG01023980001 1949395 1949676 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023980001 1949395 1949676 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023980001 1949395 1949676 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023980001 1949395 1949676 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023980001 1949395 1949676 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023980001 1949395 1949676 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01023980001 1949395 1949676 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01023980001 1949395 1949676 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01023980001 1949395 1949676 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01023980001 1949395 1949676 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01023980001 1949395 1949676 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01023980001 1949395 1949676 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01023980001 1949395 1949676 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01023980001 1949395 1949676 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01023980001 1949395 1949676 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01023980001 1949395 1949676 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ribosomal RNA. IEA GO:0019843 rRNA binding GSVIVG01023980001 1949395 1949676 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with ribosomal RNA. IEA GO:0019843 rRNA binding GSVIVG01023980001 1949395 1949676 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Interacting selectively and non-covalently with ribosomal RNA. IEA GO:0019843 rRNA binding GSVIVG01023980001 1949395 1949676 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Interacting selectively and non-covalently with ribosomal RNA. IEA GO:0019843 rRNA binding GSVIVG01023980001 1949395 1949676 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA Interacting selectively and non-covalently with ribosomal RNA. IEA GO:0019843 rRNA binding GSVIVG01003975001 26421388 26425317 GO:0006099 tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01003975001 26421388 26425317 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01003975001 26421388 26425317 GO:0006099 tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01003975001 26421388 26425317 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01003975001 26421388 26425317 GO:0006099 tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01003975001 26421388 26425317 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01008811001 2346915 2348502 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01014728001 9015339 9023045 GSVIVG01032978001 24770117 24775326 GSVIVG01026920001 19389359 19399834 GO:0000272 polysaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026920001 19389359 19399834 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026920001 19389359 19399834 GO:0000272 polysaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages. IEA Catalysis of the hydrolysis of 1,4-alpha-glucosidic linkages in polysaccharides so as to remove successive maltose units from the non-reducing ends of the chains. IEA GO:0016161 beta-amylase activity GSVIVG01026920001 19389359 19399834 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of 1,4-alpha-glucosidic linkages in polysaccharides so as to remove successive maltose units from the non-reducing ends of the chains. IEA GO:0016161 beta-amylase activity GSVIVG01026920001 19389359 19399834 GO:0000272 polysaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01026920001 19389359 19399834 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01038632001 21329147 21331591 GO:0016068 type I hypersensitivity An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells or basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines. IEA GSVIVG01007006001 29693628 29699639 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01007006001 29693628 29699639 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01035481001 1639516 1646409 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035481001 1639516 1646409 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01034965001 496252 501848 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01034965001 496252 501848 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01034965001 496252 501848 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01034965001 496252 501848 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01034965001 496252 501848 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01034965001 496252 501848 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01034965001 496252 501848 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034965001 496252 501848 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034965001 496252 501848 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01034965001 496252 501848 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01034965001 496252 501848 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01034965001 496252 501848 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01034965001 496252 501848 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate. IEA GO:0019001 guanyl nucleotide binding GSVIVG01034965001 496252 501848 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate. IEA GO:0019001 guanyl nucleotide binding GSVIVG01014412001 3531547 3536479 GO:0006790 sulfur metabolic process The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione. IEA Catalysis of the removal of a phosphate group from phosphorylated myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol. IEA GO:0004437 inositol or phosphatidylinositol phosphatase activity GSVIVG01014412001 3531547 3536479 GO:0006790 sulfur metabolic process The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione. IEA Catalysis of the reaction: adenosine 3',5'-bisphosphate + H2O = adenosine 5'-phosphate + phosphate. IEA GO:0008441 3'(2'),5'-bisphosphate nucleotidase activity GSVIVG01003433001 14964455 14981951 GO:0009231 riboflavin biosynthetic process The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). IEA Catalysis of the reaction: GTP + 3 H2O = formate + 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine + diphosphate. IEA GO:0003935 GTP cyclohydrolase II activity GSVIVG01003433001 14964455 14981951 GO:0009231 riboflavin biosynthetic process The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). IEA Catalysis of the reaction: ribulose-5-phosphate = 3,4-dihydroxy-2-butanone-4-phosphate + formate. IEA GO:0008686 3,4-dihydroxy-2-butanone-4-phosphate synthase activity GSVIVG01013073001 8739164 8746005 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01013073001 8739164 8746005 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01013073001 8739164 8746005 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01013073001 8739164 8746005 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01013073001 8739164 8746005 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01013073001 8739164 8746005 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01013073001 8739164 8746005 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01013073001 8739164 8746005 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01017832001 3851155 3856278 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01017832001 3851155 3856278 GO:0016114 terpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01017832001 3851155 3856278 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. IEA GO:0008661 1-deoxy-D-xylulose-5-phosphate synthase activity GSVIVG01017832001 3851155 3856278 GO:0016114 terpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure. IEA Catalysis of the reaction: pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. IEA GO:0008661 1-deoxy-D-xylulose-5-phosphate synthase activity GSVIVG01017832001 3851155 3856278 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide. IEA GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor GSVIVG01017832001 3851155 3856278 GO:0016114 terpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure. IEA Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide. IEA GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor GSVIVG01027548001 15781146 15781403 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01027548001 15781146 15781403 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01027548001 15781146 15781403 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01027548001 15781146 15781403 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01000448001 8095012 8095750 GSVIVG01012522001 512616 527223 GSVIVG01004440001 38584254 38585000 GSVIVG01015056001 761112 762346 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01015056001 761112 762346 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01015500001 4251587 4256072 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01015500001 4251587 4256072 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01011737001 4689631 4694454 GSVIVG01009781001 11201410 11205044 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01009781001 11201410 11205044 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01009781001 11201410 11205044 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01009781001 11201410 11205044 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01009781001 11201410 11205044 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. IEA GO:0005516 calmodulin binding GSVIVG01009781001 11201410 11205044 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. IEA GO:0005516 calmodulin binding GSVIVG01009781001 11201410 11205044 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01009781001 11201410 11205044 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01014334001 2724364 2732381 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014334001 2724364 2732381 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014334001 2724364 2732381 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014334001 2724364 2732381 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014334001 2724364 2732381 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014334001 2724364 2732381 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006593001 26937552 26941476 GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O. IEA GO:0004129 cytochrome-c oxidase activity GSVIVG01006593001 26937552 26941476 GO:0005751 mitochondrial respiratory chain complex IV A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2). IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O. IEA GO:0004129 cytochrome-c oxidase activity GSVIVG01020129001 10062440 10066525 GSVIVG01032970001 24706500 24709488 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01032970001 24706500 24709488 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01032970001 24706500 24709488 GO:0007160 cell-matrix adhesion The binding of a cell to the extracellular matrix via adhesion molecules. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01032970001 24706500 24709488 GO:0007229 integrin-mediated signaling pathway Any series of molecular signals generated as a consequence of an integrin binding to one of its physiological ligands. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01032970001 24706500 24709488 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01032970001 24706500 24709488 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01032970001 24706500 24709488 GO:0007160 cell-matrix adhesion The binding of a cell to the extracellular matrix via adhesion molecules. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01032970001 24706500 24709488 GO:0007229 integrin-mediated signaling pathway Any series of molecular signals generated as a consequence of an integrin binding to one of its physiological ligands. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01032970001 24706500 24709488 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01032970001 24706500 24709488 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01032970001 24706500 24709488 GO:0007160 cell-matrix adhesion The binding of a cell to the extracellular matrix via adhesion molecules. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01032970001 24706500 24709488 GO:0007229 integrin-mediated signaling pathway Any series of molecular signals generated as a consequence of an integrin binding to one of its physiological ligands. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01032970001 24706500 24709488 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01032970001 24706500 24709488 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01032970001 24706500 24709488 GO:0007160 cell-matrix adhesion The binding of a cell to the extracellular matrix via adhesion molecules. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01032970001 24706500 24709488 GO:0007229 integrin-mediated signaling pathway Any series of molecular signals generated as a consequence of an integrin binding to one of its physiological ligands. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01032970001 24706500 24709488 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01032970001 24706500 24709488 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01032970001 24706500 24709488 GO:0007160 cell-matrix adhesion The binding of a cell to the extracellular matrix via adhesion molecules. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01032970001 24706500 24709488 GO:0007229 integrin-mediated signaling pathway Any series of molecular signals generated as a consequence of an integrin binding to one of its physiological ligands. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01032970001 24706500 24709488 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032970001 24706500 24709488 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032970001 24706500 24709488 GO:0007160 cell-matrix adhesion The binding of a cell to the extracellular matrix via adhesion molecules. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032970001 24706500 24709488 GO:0007229 integrin-mediated signaling pathway Any series of molecular signals generated as a consequence of an integrin binding to one of its physiological ligands. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032970001 24706500 24709488 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032970001 24706500 24709488 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032970001 24706500 24709488 GO:0007160 cell-matrix adhesion The binding of a cell to the extracellular matrix via adhesion molecules. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032970001 24706500 24709488 GO:0007229 integrin-mediated signaling pathway Any series of molecular signals generated as a consequence of an integrin binding to one of its physiological ligands. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019602001 1865270 1872643 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027558001 15595607 15612471 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01027558001 15595607 15612471 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01027558001 15595607 15612471 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01027558001 15595607 15612471 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01027558001 15595607 15612471 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01027558001 15595607 15612471 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01037538001 11840584 11853526 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: 3-alpha(S)-strictosidine = tryptamine + secologanin. IEA GO:0016844 strictosidine synthase activity GSVIVG01030895001 18502043 18509141 GSVIVG01013720001 8215666 8218166 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01030613001 7174990 7176769 Functions in the storage of nutritious substrates. IEA GO:0045735 nutrient reservoir activity GSVIVG01007927001 7475229 7477459 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01031684001 20145287 20148310 GSVIVG01034111001 15082066 15087740 GSVIVG01021950001 5214851 5216040 GO:0006801 superoxide metabolic process The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01021950001 5214851 5216040 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01006474001 26277518 26282041 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01006474001 26277518 26282041 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01006474001 26277518 26282041 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01006474001 26277518 26282041 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01006474001 26277518 26282041 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01006474001 26277518 26282041 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01006474001 26277518 26282041 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01006474001 26277518 26282041 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01006474001 26277518 26282041 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01006474001 26277518 26282041 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01006474001 26277518 26282041 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01006474001 26277518 26282041 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01006474001 26277518 26282041 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01006474001 26277518 26282041 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01006474001 26277518 26282041 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01006474001 26277518 26282041 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01006474001 26277518 26282041 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01006474001 26277518 26282041 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01006474001 26277518 26282041 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. IEA GO:0016615 malate dehydrogenase activity GSVIVG01006474001 26277518 26282041 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. IEA GO:0016615 malate dehydrogenase activity GSVIVG01006474001 26277518 26282041 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. IEA GO:0016615 malate dehydrogenase activity GSVIVG01006474001 26277518 26282041 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. IEA GO:0016615 malate dehydrogenase activity GSVIVG01006474001 26277518 26282041 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. IEA GO:0016615 malate dehydrogenase activity GSVIVG01006474001 26277518 26282041 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. IEA GO:0016615 malate dehydrogenase activity GSVIVG01006474001 26277518 26282041 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01006474001 26277518 26282041 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01006474001 26277518 26282041 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01006474001 26277518 26282041 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01006474001 26277518 26282041 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01006474001 26277518 26282041 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01006474001 26277518 26282041 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids. IEA GO:0030060 L-malate dehydrogenase activity GSVIVG01006474001 26277518 26282041 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids. IEA GO:0030060 L-malate dehydrogenase activity GSVIVG01006474001 26277518 26282041 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids. IEA GO:0030060 L-malate dehydrogenase activity GSVIVG01006474001 26277518 26282041 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids. IEA GO:0030060 L-malate dehydrogenase activity GSVIVG01006474001 26277518 26282041 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids. IEA GO:0030060 L-malate dehydrogenase activity GSVIVG01006474001 26277518 26282041 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids. IEA GO:0030060 L-malate dehydrogenase activity GSVIVG01003207001 7905955 7913532 GSVIVG01005594001 40778237 40779188 GSVIVG01016561001 2766818 2771563 GO:0006364 rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016561001 2766818 2771563 GO:0006364 rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. IEA GO:0008173 RNA methyltransferase activity GSVIVG01016561001 2766818 2771563 GO:0006364 rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01018194001 13365126 13370358 GSVIVG01002932001 37235345 37240782 GSVIVG01034649001 13392064 13392935 GSVIVG01009073001 4728333 4729667 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01034174001 14633075 14634289 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01006203001 23667807 23668328 GO:0006278 RNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01006203001 23667807 23668328 GO:0008380 RNA splicing The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01006203001 23667807 23668328 GO:0006278 RNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time. IEA GO:0003964 RNA-directed DNA polymerase activity GSVIVG01006203001 23667807 23668328 GO:0008380 RNA splicing The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time. IEA GO:0003964 RNA-directed DNA polymerase activity GSVIVG01003208001 7915233 7916610 GSVIVG01026486001 22820968 22829378 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01020489001 18550102 18552220 Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01034766001 9250055 9250801 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01034766001 9250055 9250801 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038347001 13338991 13343985 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01038347001 13338991 13343985 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01038347001 13338991 13343985 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01038347001 13338991 13343985 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038347001 13338991 13343985 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01009747001 10940277 10945762 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA Catalysis of the reaction: ATP + alpha-D-glucose 1-phosphate = diphosphate + ADP-glucose. IEA GO:0008878 glucose-1-phosphate adenylyltransferase activity GSVIVG01009747001 10940277 10945762 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: ATP + alpha-D-glucose 1-phosphate = diphosphate + ADP-glucose. IEA GO:0008878 glucose-1-phosphate adenylyltransferase activity GSVIVG01009747001 10940277 10945762 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA Catalysis of the transfer of a nucleotidyl group to a reactant. IEA GO:0016779 nucleotidyltransferase activity GSVIVG01009747001 10940277 10945762 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nucleotidyl group to a reactant. IEA GO:0016779 nucleotidyltransferase activity GSVIVG01009895001 12212224 12215228 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01016821001 1659918 1666358 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008237 metallopeptidase activity GSVIVG01016821001 1659918 1666358 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01016930001 2668179 2668714 GSVIVG01018247001 12566181 12593884 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01018247001 12566181 12593884 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01018247001 12566181 12593884 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01018247001 12566181 12593884 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01018247001 12566181 12593884 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01018247001 12566181 12593884 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01018247001 12566181 12593884 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any transcription regulator activity required for initiation or upregulation of transcription. IEA GO:0016563 transcription activator activity GSVIVG01018247001 12566181 12593884 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any transcription regulator activity required for initiation or upregulation of transcription. IEA GO:0016563 transcription activator activity GSVIVG01018247001 12566181 12593884 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any transcription regulator activity required for initiation or upregulation of transcription. IEA GO:0016563 transcription activator activity GSVIVG01018247001 12566181 12593884 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01018247001 12566181 12593884 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01018247001 12566181 12593884 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01018247001 12566181 12593884 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01018247001 12566181 12593884 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01018247001 12566181 12593884 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01026530001 22216318 22217379 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01011958001 2632790 2636084 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01011958001 2632790 2636084 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035964001 6555518 6566325 GO:0007067 mitosis A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell. IEA GO:0000775 chromosome, centromeric region The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome. IEA GSVIVG01029958001 2200546 2308835 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule. IEA GO:0000175 3'-5'-exoribonuclease activity GSVIVG01029958001 2200546 2308835 GO:0006402 mRNA catabolic process The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule. IEA GO:0000175 3'-5'-exoribonuclease activity GSVIVG01029958001 2200546 2308835 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01029958001 2200546 2308835 GO:0006402 mRNA catabolic process The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01029958001 2200546 2308835 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of the reaction: ATP + RNA(n) = diphosphate + RNA(n+1). IEA GO:0004654 polyribonucleotide nucleotidyltransferase activity GSVIVG01029958001 2200546 2308835 GO:0006402 mRNA catabolic process The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of the reaction: ATP + RNA(n) = diphosphate + RNA(n+1). IEA GO:0004654 polyribonucleotide nucleotidyltransferase activity GSVIVG01038687001 21004457 21010493 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01038687001 21004457 21010493 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01038687001 21004457 21010493 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038687001 21004457 21010493 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038687001 21004457 21010493 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01038687001 21004457 21010493 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01038687001 21004457 21010493 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01038687001 21004457 21010493 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01038687001 21004457 21010493 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01038687001 21004457 21010493 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01035800001 4471176 4475207 GO:0006820 anion transport The directed movement of anions, atoms or small molecules with a net negative charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA IEA GO:0005452 inorganic anion exchanger activity GSVIVG01035800001 4471176 4475207 GO:0006820 anion transport The directed movement of anions, atoms or small molecules with a net negative charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA IEA GO:0005452 inorganic anion exchanger activity GSVIVG01035800001 4471176 4475207 GO:0006820 anion transport The directed movement of anions, atoms or small molecules with a net negative charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA IEA GO:0015380 anion exchanger activity GSVIVG01035800001 4471176 4475207 GO:0006820 anion transport The directed movement of anions, atoms or small molecules with a net negative charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA IEA GO:0015380 anion exchanger activity GSVIVG01011987001 2395309 2400043 GSVIVG01035857001 4924825 4933011 GSVIVG01008335001 3148656 3153072 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012150001 1017874 1019921 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01038256001 24744322 24745251 GSVIVG01036911001 17760098 17774855 GO:0000272 polysaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01036911001 17760098 17774855 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01036911001 17760098 17774855 GO:0000272 polysaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages. IEA Catalysis of the hydrolysis of 1,4-alpha-glucosidic linkages in polysaccharides so as to remove successive maltose units from the non-reducing ends of the chains. IEA GO:0016161 beta-amylase activity GSVIVG01036911001 17760098 17774855 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of 1,4-alpha-glucosidic linkages in polysaccharides so as to remove successive maltose units from the non-reducing ends of the chains. IEA GO:0016161 beta-amylase activity GSVIVG01036911001 17760098 17774855 GO:0000272 polysaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01036911001 17760098 17774855 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01032425001 27284602 27287525 GSVIVG01027140001 17502766 17512554 GSVIVG01033285001 21825506 21829098 GO:0006694 steroid biosynthetic process The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01033285001 21825506 21829098 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01033285001 21825506 21829098 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01033285001 21825506 21829098 GO:0032259 methylation The process by which a methyl group is covalently attached to a molecule. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01033285001 21825506 21829098 GO:0006694 steroid biosynthetic process The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01033285001 21825506 21829098 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01033285001 21825506 21829098 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01033285001 21825506 21829098 GO:0032259 methylation The process by which a methyl group is covalently attached to a molecule. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01033285001 21825506 21829098 GO:0006694 steroid biosynthetic process The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification. IEA Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid. IEA GO:0008825 cyclopropane-fatty-acyl-phospholipid synthase activity GSVIVG01033285001 21825506 21829098 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid. IEA GO:0008825 cyclopropane-fatty-acyl-phospholipid synthase activity GSVIVG01033285001 21825506 21829098 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid. IEA GO:0008825 cyclopropane-fatty-acyl-phospholipid synthase activity GSVIVG01033285001 21825506 21829098 GO:0032259 methylation The process by which a methyl group is covalently attached to a molecule. IEA Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid. IEA GO:0008825 cyclopropane-fatty-acyl-phospholipid synthase activity GSVIVG01013315001 11786801 11797997 GSVIVG01021044001 14776362 14776686 GSVIVG01028068001 3575837 3579746 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion. IEA GO:0005484 SNAP receptor activity GSVIVG01028068001 3575837 3579746 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion. IEA GO:0005484 SNAP receptor activity GSVIVG01028068001 3575837 3579746 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01028068001 3575837 3579746 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012065001 1692024 1696196 GSVIVG01002509001 35102197 35103532 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01002509001 35102197 35103532 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01029563001 21518834 21536889 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: diphosphate + H2O = 2 phosphate. IEA GO:0004427 inorganic diphosphatase activity GSVIVG01029563001 21518834 21536889 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: diphosphate + H2O = 2 phosphate. IEA GO:0004427 inorganic diphosphatase activity GSVIVG01029563001 21518834 21536889 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01029563001 21518834 21536889 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01029563001 21518834 21536889 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of pyrophosphate, which generates a proton motive force. IEA GO:0009678 hydrogen-translocating pyrophosphatase activity GSVIVG01029563001 21518834 21536889 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of pyrophosphate, which generates a proton motive force. IEA GO:0009678 hydrogen-translocating pyrophosphatase activity GSVIVG01018530001 13772824 13776194 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01018530001 13772824 13776194 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01023691001 9399825 9408030 GSVIVG01009704001 10641023 10646767 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01035630001 2835735 2842423 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01029996001 8787638 8801412 GSVIVG01028718001 19477141 19479868 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01028718001 19477141 19479868 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01028251001 4947058 4953538 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030127 COPII vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01028251001 4947058 4953538 GO:0006888 ER to Golgi vesicle-mediated transport The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi. IEA GO:0030127 COPII vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01028251001 4947058 4953538 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030127 COPII vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01028251001 4947058 4953538 GO:0006888 ER to Golgi vesicle-mediated transport The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi. IEA GO:0030127 COPII vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01014442001 3814610 3826987 GSVIVG01020210001 8987938 8989738 GSVIVG01025408001 1013333 1014492 GO:0006869 lipid transport The directed movement of lipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Interacting selectively and non-covalently with a lipid. IEA GO:0008289 lipid binding GSVIVG01011331001 8640366 8640626 GSVIVG01017726001 2955066 2962398 GSVIVG01029623001 20565634 20573112 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of the terminal 1,2-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2). IEA GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity GSVIVG01029623001 20565634 20573112 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01035840001 4786682 4788669 GSVIVG01034888001 15986161 15987116 GSVIVG01032155001 22063676 22069529 GO:0006694 steroid biosynthetic process The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01032155001 22063676 22069529 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01011823001 3833982 3837984 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01000577001 6911855 6915565 GSVIVG01000117001 15400077 15400608 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01017732001 2993281 2998576 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01015976001 16666088 16668229 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01015976001 16666088 16668229 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01015976001 16666088 16668229 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015976001 16666088 16668229 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019734001 2828670 2842078 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019734001 2828670 2842078 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019734001 2828670 2842078 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019734001 2828670 2842078 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019734001 2828670 2842078 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019734001 2828670 2842078 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019734001 2828670 2842078 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019734001 2828670 2842078 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019734001 2828670 2842078 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01019734001 2828670 2842078 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01019734001 2828670 2842078 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01019734001 2828670 2842078 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01019734001 2828670 2842078 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01019734001 2828670 2842078 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01019734001 2828670 2842078 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01019734001 2828670 2842078 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01019734001 2828670 2842078 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01019734001 2828670 2842078 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01019734001 2828670 2842078 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01019734001 2828670 2842078 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01019734001 2828670 2842078 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01019734001 2828670 2842078 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01019734001 2828670 2842078 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01019734001 2828670 2842078 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01019734001 2828670 2842078 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019734001 2828670 2842078 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019734001 2828670 2842078 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019734001 2828670 2842078 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019734001 2828670 2842078 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019734001 2828670 2842078 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019734001 2828670 2842078 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019734001 2828670 2842078 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019734001 2828670 2842078 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01019734001 2828670 2842078 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01019734001 2828670 2842078 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01019734001 2828670 2842078 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01019734001 2828670 2842078 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01019734001 2828670 2842078 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01019734001 2828670 2842078 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01019734001 2828670 2842078 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01019734001 2828670 2842078 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01019734001 2828670 2842078 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01019734001 2828670 2842078 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01019734001 2828670 2842078 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01019734001 2828670 2842078 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01019734001 2828670 2842078 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01019734001 2828670 2842078 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01019734001 2828670 2842078 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01019734001 2828670 2842078 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01019734001 2828670 2842078 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01019734001 2828670 2842078 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01019734001 2828670 2842078 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01019734001 2828670 2842078 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01019734001 2828670 2842078 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01019734001 2828670 2842078 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01019734001 2828670 2842078 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01019734001 2828670 2842078 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01019734001 2828670 2842078 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01019734001 2828670 2842078 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01019734001 2828670 2842078 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01019734001 2828670 2842078 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01019734001 2828670 2842078 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01019734001 2828670 2842078 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01019734001 2828670 2842078 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01019734001 2828670 2842078 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01019734001 2828670 2842078 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01019734001 2828670 2842078 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01019734001 2828670 2842078 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01019734001 2828670 2842078 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01019734001 2828670 2842078 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01019734001 2828670 2842078 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01019734001 2828670 2842078 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01020517001 4887507 4918331 GSVIVG01000564001 7027704 7030273 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01000564001 7027704 7030273 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01000564001 7027704 7030273 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01000564001 7027704 7030273 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01038271001 24864593 24868199 GSVIVG01006687001 27536776 27545565 GSVIVG01008741001 1615551 1618288 GSVIVG01031612001 18925518 18926513 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031612001 18925518 18926513 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031612001 18925518 18926513 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01031612001 18925518 18926513 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01014158001 917967 921705 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01014158001 917967 921705 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01028486001 8243043 8246279 GSVIVG01016341001 4794885 4799293 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01016341001 4794885 4799293 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01016341001 4794885 4799293 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015935 small ribosomal subunit The smaller of the two subunits of a ribosome. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01016341001 4794885 4799293 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01015588001 5267554 5284487 GSVIVG01032697001 1445724 1449105 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01032697001 1445724 1449105 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N2-methylguanine. IEA GO:0004809 tRNA (guanine-N2-)-methyltransferase activity GSVIVG01027263001 17442747 17443614 GSVIVG01019753001 2977850 2988157 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01019753001 2977850 2988157 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025239001 2818632 2825226 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025239001 2818632 2825226 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025239001 2818632 2825226 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025239001 2818632 2825226 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025239001 2818632 2825226 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01025239001 2818632 2825226 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01024988001 5459869 5468755 GSVIVG01035885001 5265806 5268041 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01035885001 5265806 5268041 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01000260001 20659641 20670506 GSVIVG01010501001 21119833 21128587 Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01017326001 6731971 6735116 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01017326001 6731971 6735116 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01017326001 6731971 6735116 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01017326001 6731971 6735116 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01017326001 6731971 6735116 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01017326001 6731971 6735116 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01017326001 6731971 6735116 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017326001 6731971 6735116 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017326001 6731971 6735116 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01017326001 6731971 6735116 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01017326001 6731971 6735116 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01017326001 6731971 6735116 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01020082001 10581618 10588247 GSVIVG01038435001 12208885 12208989 GSVIVG01034504001 20209652 20211072 GSVIVG01025857001 11127257 11131314 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025857001 11127257 11131314 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01018012001 5464956 5468872 Catalysis of the removal of a phosphate group from phosphorylated myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol. IEA GO:0004437 inositol or phosphatidylinositol phosphatase activity GSVIVG01014608001 5632105 5640466 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01035167001 12505370 12507165 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035167001 12505370 12507165 Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. IEA GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GSVIVG01009833001 11636131 11641171 GSVIVG01027969001 2887397 2888719 GSVIVG01014548001 5040499 5041712 GSVIVG01032961001 24626255 24627037 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01032961001 24626255 24627037 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01000653001 20437713 20440079 GSVIVG01022455001 3228726 3235692 Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01022455001 3228726 3235692 Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01022455001 3228726 3235692 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01022455001 3228726 3235692 Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01001132001 22867507 22871451 GSVIVG01007922001 7517364 7520896 GSVIVG01011620001 5847648 5850416 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01011620001 5847648 5850416 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01011620001 5847648 5850416 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01011620001 5847648 5850416 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01011620001 5847648 5850416 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01011620001 5847648 5850416 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01011620001 5847648 5850416 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01011620001 5847648 5850416 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01011620001 5847648 5850416 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011620001 5847648 5850416 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011620001 5847648 5850416 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01011620001 5847648 5850416 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01019879001 4153191 4161632 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019879001 4153191 4161632 GO:0046470 phosphatidylcholine metabolic process The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019879001 4153191 4161632 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate. IEA GO:0004630 phospholipase D activity GSVIVG01019879001 4153191 4161632 GO:0046470 phosphatidylcholine metabolic process The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate. IEA GO:0004630 phospholipase D activity GSVIVG01019879001 4153191 4161632 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01019879001 4153191 4161632 GO:0046470 phosphatidylcholine metabolic process The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01029882001 911167 917478 GSVIVG01008381001 2676007 2681814 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01019065001 17179503 17200164 GSVIVG01028077001 3644524 3646604 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01028077001 3644524 3646604 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01028077001 3644524 3646604 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01028077001 3644524 3646604 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate. IEA GO:0019001 guanyl nucleotide binding GSVIVG01023575001 9423448 9426437 GSVIVG01014302001 2484297 2485658 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01037635001 6416897 6422786 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01037635001 6416897 6422786 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01037635001 6416897 6422786 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01000465001 8227448 8228242 GSVIVG01026823001 20181767 20188704 GSVIVG01008930001 3515280 3530530 GO:0008202 steroid metabolic process The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. IEA GSVIVG01015322001 2676722 2693431 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a oligosaccharyl group to an acceptor molecule, typically another carbohydrate or a lipid. IEA GO:0004576 oligosaccharyl transferase activity GSVIVG01015322001 2676722 2693431 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01026367001 15123328 15124227 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035634001 2880130 2880892 GSVIVG01012002001 2282307 2285389 GSVIVG01020690001 3074486 3080348 GSVIVG01018303001 11452323 11460727 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032872001 83300 93882 GSVIVG01004313001 38041889 38042652 GSVIVG01031318001 408061 412961 GSVIVG01007118001 30155002 30161071 GSVIVG01033455001 20557324 20559688 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01033455001 20557324 20559688 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01038640001 21283942 21286566 GSVIVG01025878001 27592348 27597480 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01002582001 35302755 35306684 GSVIVG01024542001 9015606 9016608 GO:0009416 response to light stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01018251001 12524491 12530525 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01018251001 12524491 12530525 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01018251001 12524491 12530525 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01020343001 21058385 21062740 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020343001 21058385 21062740 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020343001 21058385 21062740 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020343001 21058385 21062740 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031824001 4709979 4710972 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01020662001 3325921 3341451 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01026721001 5533817 5586682 GSVIVG01008481001 1501867 1502124 GSVIVG01024228001 7726 12080 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01024228001 7726 12080 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024228001 7726 12080 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01024228001 7726 12080 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01020011001 11610081 11611375 GSVIVG01031314001 439701 448856 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01031314001 439701 448856 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031314001 439701 448856 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01031314001 439701 448856 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01011899001 3175425 3178989 Catalysis of the reaction: S-adenosyl-L-methionine + L-homocysteine = S-adenosyl-L-homocysteine + L-methionine. IEA GO:0008898 homocysteine S-methyltransferase activity GSVIVG01003900001 13372265 13375717 GSVIVG01018342001 10770077 10770627 GSVIVG01028233001 4817340 4819119 GSVIVG01027886001 9032940 9048206 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01027886001 9032940 9048206 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01027886001 9032940 9048206 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid. IEA GO:0008825 cyclopropane-fatty-acyl-phospholipid synthase activity GSVIVG01027886001 9032940 9048206 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid. IEA GO:0008825 cyclopropane-fatty-acyl-phospholipid synthase activity GSVIVG01027886001 9032940 9048206 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01027886001 9032940 9048206 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01009763001 11099584 11102318 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01010477001 20925190 20932874 Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. IEA GO:0016791 phosphatase activity GSVIVG01024126001 898286 903569 GSVIVG01000441001 8053062 8056733 GO:0006879 cellular iron ion homeostasis Any process involved in the maintenance of an internal steady-state of iron ions at the level of a cell. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA GSVIVG01008254001 4031362 4061477 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016286001 5537559 5543203 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA GSVIVG01016286001 5537559 5543203 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GSVIVG01032797001 673495 712006 GSVIVG01017963001 5108616 5111341 GSVIVG01028916001 17582059 17587160 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion. IEA GO:0004091 carboxylesterase activity GSVIVG01028916001 17582059 17587160 GO:0016042 lipid catabolic process The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion. IEA GO:0004091 carboxylesterase activity GSVIVG01028916001 17582059 17587160 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion. IEA GO:0004806 triglyceride lipase activity GSVIVG01028916001 17582059 17587160 GO:0016042 lipid catabolic process The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion. IEA GO:0004806 triglyceride lipase activity GSVIVG01020716001 2794563 2804226 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01020716001 2794563 2804226 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01020716001 2794563 2804226 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01020716001 2794563 2804226 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01009010001 4254678 4257404 GO:0005992 trehalose biosynthetic process The chemical reactions and pathways resulting in the formation of trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009010001 4254678 4257404 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01034592001 14787502 14788705 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar. IEA GO:0008375 acetylglucosaminyltransferase activity GSVIVG01020006001 11714601 11721062 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01020006001 11714601 11721062 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2-phosphoglycolate + H2O = glycolate + phosphate. IEA GO:0008967 phosphoglycolate phosphatase activity GSVIVG01020006001 11714601 11721062 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01032565001 28402554 28406765 GSVIVG01025483001 415373 415654 GSVIVG01004113001 14968202 14968827 GSVIVG01036938001 17315634 17315882 GSVIVG01029694001 13189932 13196522 GSVIVG01037911001 6399870 6405760 GSVIVG01024047001 1512350 1518378 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). IEA GO:0003755 peptidyl-prolyl cis-trans isomerase activity GSVIVG01010910001 15819289 15821254 GO:0006414 translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01010910001 15819289 15821254 GO:0006414 translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01015294001 2455389 2456542 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01015294001 2455389 2456542 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01015294001 2455389 2456542 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01015294001 2455389 2456542 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01009574001 9539944 9541391 Interacting selectively and non-covalently with single-stranded DNA. IEA GO:0003697 single-stranded DNA binding GSVIVG01008307001 3414629 3417929 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01008307001 3414629 3417929 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01021202001 2522868 2529535 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021202001 2522868 2529535 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027938001 9763795 9777367 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01027938001 9763795 9777367 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA Catalysis of the transfer of the amide nitrogen of glutamine to a variety of substrates. GATases catalyze two separate reactions at two active sites, which are located either on a single polypeptide chain or on different subunits. In the glutaminase reaction, glutamine is hydrolyzed to glutamate and ammonia, which is added to an acceptor substrate in the synthase reaction. IEA GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor GSVIVG01030135001 10135156 10136024 GSVIVG01031843001 4813764 4817457 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01031843001 4813764 4817457 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA A ligand-dependent receptor found in the nucleus of the cell. IEA GO:0004879 ligand-dependent nuclear receptor activity GSVIVG01031843001 4813764 4817457 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The action of a molecule that contributes to the structural integrity of a cell wall. IEA GO:0005199 structural constituent of cell wall GSVIVG01031843001 4813764 4817457 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01028375001 6786671 6787069 GSVIVG01006971001 29486650 29489457 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01021354001 4375798 4377294 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01021354001 4375798 4377294 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01021354001 4375798 4377294 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01021354001 4375798 4377294 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01021354001 4375798 4377294 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01021354001 4375798 4377294 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01021354001 4375798 4377294 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01021354001 4375798 4377294 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01016272001 5640475 5655021 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01016272001 5640475 5655021 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01016272001 5640475 5655021 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01016272001 5640475 5655021 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01016272001 5640475 5655021 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01016272001 5640475 5655021 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01038218001 24441629 24443684 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01038218001 24441629 24443684 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01038218001 24441629 24443684 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015934 large ribosomal subunit The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01038218001 24441629 24443684 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01038218001 24441629 24443684 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01038218001 24441629 24443684 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015934 large ribosomal subunit The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01038218001 24441629 24443684 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01038218001 24441629 24443684 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01038218001 24441629 24443684 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015934 large ribosomal subunit The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01029951001 2044296 2047160 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: cysteamine + O2 = hypotaurine. IEA GO:0047800 cysteamine dioxygenase activity GSVIVG01007815001 8768694 8770406 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01021196001 2474037 2488163 GSVIVG01025420001 943985 953273 Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity. IEA GO:0004721 phosphoprotein phosphatase activity GSVIVG01025420001 943985 953273 Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01025420001 943985 953273 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01000581001 6875154 6876150 GSVIVG01033625001 19142465 19144854 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GSVIVG01018599001 12503456 12517626 GSVIVG01012564001 3684687 3693299 GSVIVG01008835001 2604468 2613076 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008835001 2604468 2613076 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01008835001 2604468 2613076 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01008835001 2604468 2613076 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01026889001 19628364 19629972 GSVIVG01037537001 11873240 11874698 GO:0046488 phosphatidylinositol metabolic process The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. IEA Catalysis of the phosphorylation of phosphatidylinositol phosphate to produce phosphatidylinositol bisphosphate. IEA GO:0016307 phosphatidylinositol phosphate kinase activity GSVIVG01005217001 19293276 19301054 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01005217001 19293276 19301054 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01014307001 2528398 2530537 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01014307001 2528398 2530537 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01014307001 2528398 2530537 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01014307001 2528398 2530537 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01018572001 13216257 13234198 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01034992001 749324 751897 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01034992001 749324 751897 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01034992001 749324 751897 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01034992001 749324 751897 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031144001 1758888 1764995 GSVIVG01035593001 2582427 2595604 GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01024185001 512368 513361 GSVIVG01007537001 12508380 12516414 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01007537001 12508380 12516414 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028389001 6971562 6994488 GSVIVG01017994001 5336359 5337658 GSVIVG01031664001 19809629 19814198 GSVIVG01037436001 13770734 13778856 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01000399001 753211 773147 GSVIVG01025302001 2284089 2292212 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01025302001 2284089 2292212 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01014174001 1119849 1123813 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01014174001 1119849 1123813 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01012898001 6630888 6634015 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). IEA GO:0003755 peptidyl-prolyl cis-trans isomerase activity GSVIVG01029522001 22017465 22019105 GSVIVG01018975001 18196920 18200082 GSVIVG01035599001 2611677 2616490 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01029449001 22752122 22771893 GSVIVG01032443001 27454898 27458409 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01028740001 19240225 19246621 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01028740001 19240225 19246621 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01028740001 19240225 19246621 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028740001 19240225 19246621 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01028740001 19240225 19246621 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01002108001 32986033 32987205 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01002108001 32986033 32987205 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01017283001 6353300 6354690 GSVIVG01034196001 14510755 14517473 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01034196001 14510755 14517473 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01033795001 17765904 17766542 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01033795001 17765904 17766542 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01027073001 18157737 18162959 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01016867001 2109341 2111892 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01026629001 20897681 20900291 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026629001 20897681 20900291 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026629001 20897681 20900291 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026629001 20897681 20900291 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026629001 20897681 20900291 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01026629001 20897681 20900291 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01026629001 20897681 20900291 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01026629001 20897681 20900291 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01035884001 5247592 5248886 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035884001 5247592 5248886 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035884001 5247592 5248886 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01035884001 5247592 5248886 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01035884001 5247592 5248886 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01035884001 5247592 5248886 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01028416001 7371024 7379138 GSVIVG01015779001 17403197 17428076 GSVIVG01032570001 28466127 28468608 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01032570001 28466127 28468608 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01032570001 28466127 28468608 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01032570001 28466127 28468608 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032570001 28466127 28468608 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030165001 10907624 10911693 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030165001 10907624 10911693 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01030165001 10907624 10911693 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01021066001 14190413 14193748 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01030565001 6779071 6789767 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01030565001 6779071 6789767 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01030565001 6779071 6789767 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01030565001 6779071 6789767 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01030565001 6779071 6789767 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01030565001 6779071 6789767 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01030565001 6779071 6789767 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01030565001 6779071 6789767 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01030565001 6779071 6789767 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030565001 6779071 6789767 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030565001 6779071 6789767 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030565001 6779071 6789767 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001111001 22694141 22703040 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01014010001 8924020 8925465 GSVIVG01023070001 15905580 15910686 GSVIVG01028649001 11589415 11590374 GSVIVG01025428001 880477 881939 GSVIVG01000543001 7248978 7253673 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000543001 7248978 7253673 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. IEA GO:0004722 protein serine/threonine phosphatase activity GSVIVG01020713001 2833429 2837359 GSVIVG01004937001 21666020 21669215 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004185 serine-type carboxypeptidase activity GSVIVG01014637001 8052648 8091236 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01014637001 8052648 8091236 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01014637001 8052648 8091236 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01014637001 8052648 8091236 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01022271001 18050638 18062631 GSVIVG01029613001 20758813 20765245 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01029613001 20758813 20765245 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01029603001 20847539 20849248 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01029603001 20847539 20849248 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01017787001 3474595 3474903 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01017787001 3474595 3474903 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds. IEA GO:0015035 protein disulfide oxidoreductase activity GSVIVG01008420001 2265250 2268301 GSVIVG01015347001 2859479 2867134 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01015347001 2859479 2867134 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01015347001 2859479 2867134 GO:0006414 translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01015347001 2859479 2867134 GO:0006414 translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01015347001 2859479 2867134 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01015347001 2859479 2867134 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01015347001 2859479 2867134 GO:0006414 translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01015347001 2859479 2867134 GO:0006414 translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01015347001 2859479 2867134 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Functions in chain elongation during polypeptide synthesis at the ribosome. IEA GO:0003746 translation elongation factor activity GSVIVG01015347001 2859479 2867134 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Functions in chain elongation during polypeptide synthesis at the ribosome. IEA GO:0003746 translation elongation factor activity GSVIVG01015347001 2859479 2867134 GO:0006414 translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Functions in chain elongation during polypeptide synthesis at the ribosome. IEA GO:0003746 translation elongation factor activity GSVIVG01015347001 2859479 2867134 GO:0006414 translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Functions in chain elongation during polypeptide synthesis at the ribosome. IEA GO:0003746 translation elongation factor activity GSVIVG01038444001 12418512 12425685 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01011831001 3782673 3782875 GSVIVG01013748001 7963567 7968686 GSVIVG01001905001 7073436 7076748 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01001905001 7073436 7076748 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01001905001 7073436 7076748 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with 5S ribosomal RNA, the smallest RNA constituent of a ribosome. IEA GO:0008097 5S rRNA binding GSVIVG01001905001 7073436 7076748 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with 5S ribosomal RNA, the smallest RNA constituent of a ribosome. IEA GO:0008097 5S rRNA binding GSVIVG01033981001 16124477 16125908 GSVIVG01020894001 17661804 17662862 GSVIVG01010496001 21064305 21071687 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01013575001 21098680 21109331 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01013575001 21098680 21109331 Interacting selectively and non-covalently with thiamin pyrophosphate, the diphosphoric ester of thiamin. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases. IEA GO:0030976 thiamin pyrophosphate binding GSVIVG01038466001 9751600 9771387 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01038466001 9751600 9771387 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01038466001 9751600 9771387 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01038466001 9751600 9771387 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013710001 2926250 2927920 GSVIVG01035670001 3178425 3182278 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01035751001 3982693 3982800 GSVIVG01011647001 5609430 5615970 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01035205001 10446717 10448235 The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01035859001 4952205 4954652 Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01037855001 7074728 7076677 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01037855001 7074728 7076677 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01037855001 7074728 7076677 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01037855001 7074728 7076677 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01037855001 7074728 7076677 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01037855001 7074728 7076677 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01037855001 7074728 7076677 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01037855001 7074728 7076677 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01025700001 12845836 12854444 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01024985001 5497870 5504259 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01031339001 262240 262770 GSVIVG01012908001 13288556 13288857 GSVIVG01003167001 6033619 6037846 GSVIVG01028179001 4454809 4456525 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01028179001 4454809 4456525 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01028179001 4454809 4456525 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01028179001 4454809 4456525 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01028179001 4454809 4456525 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01028179001 4454809 4456525 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01028179001 4454809 4456525 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01028179001 4454809 4456525 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01028179001 4454809 4456525 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate. IEA GO:0019001 guanyl nucleotide binding GSVIVG01028179001 4454809 4456525 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate. IEA GO:0019001 guanyl nucleotide binding GSVIVG01028179001 4454809 4456525 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate. IEA GO:0019001 guanyl nucleotide binding GSVIVG01028179001 4454809 4456525 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate. IEA GO:0019001 guanyl nucleotide binding GSVIVG01019074001 17037833 17057049 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004185 serine-type carboxypeptidase activity GSVIVG01032637001 1958226 1964689 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032637001 1958226 1964689 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. IEA GO:0004722 protein serine/threonine phosphatase activity GSVIVG01011360001 28944144 28951211 GSVIVG01037862001 7035492 7039129 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01009141001 5477436 5481168 Interacting selectively and non-covalently with a specific domain of a protein. IEA GO:0019904 protein domain specific binding GSVIVG01009616001 9911109 9912876 Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01009616001 9911109 9912876 Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01009616001 9911109 9912876 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01009616001 9911109 9912876 Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01029438001 22900329 22902767 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01029438001 22900329 22902767 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01029438001 22900329 22902767 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029438001 22900329 22902767 Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01014761001 9373956 9376573 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01007556001 12198712 12199283 GSVIVG01020523001 4852014 4852643 GSVIVG01036522001 23022053 23026181 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01033922001 16697190 16698040 GSVIVG01009674001 10357647 10358778 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01009674001 10357647 10358778 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01009674001 10357647 10358778 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01009674001 10357647 10358778 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01011527001 13058118 13081615 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01011527001 13058118 13081615 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01011527001 13058118 13081615 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01011527001 13058118 13081615 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011527001 13058118 13081615 Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01011527001 13058118 13081615 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01011527001 13058118 13081615 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01032197001 21617294 21623821 GSVIVG01023602001 7847109 7852068 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01023602001 7847109 7852068 GO:0006284 base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01023602001 7847109 7852068 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the hydrolysis of alkylated DNA; only recognizes and removes the alkylated base 3-methyladenine by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site. IEA GO:0008725 DNA-3-methyladenine glycosylase I activity GSVIVG01023602001 7847109 7852068 GO:0006284 base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. IEA Catalysis of the hydrolysis of alkylated DNA; only recognizes and removes the alkylated base 3-methyladenine by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site. IEA GO:0008725 DNA-3-methyladenine glycosylase I activity GSVIVG01023826001 3176215 3181195 Catalysis of the removal of a phosphate group from phosphorylated myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol. IEA GO:0004437 inositol or phosphatidylinositol phosphatase activity GSVIVG01007152001 5432504 5432686 GSVIVG01022469001 3434848 3435482 GSVIVG01008270001 3767749 3773002 GSVIVG01028936001 17226709 17238324 GSVIVG01036912001 17748345 17758642 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036912001 17748345 17758642 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01030017001 8957404 8959057 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01014381001 3256084 3262753 GSVIVG01015418001 3478593 3484139 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01015418001 3478593 3484139 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01034492001 20442856 20449338 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01034492001 20442856 20449338 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01008059001 6167656 6170182 GO:0006820 anion transport The directed movement of anions, atoms or small molecules with a net negative charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005741 mitochondrial outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope. IEA Catalysis of the transmembrane transfer of an anion by a voltage-gated channel. An anion is a negatively charged ion. IEA GO:0008308 voltage-gated anion channel activity GSVIVG01008059001 6167656 6170182 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005741 mitochondrial outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope. IEA Catalysis of the transmembrane transfer of an anion by a voltage-gated channel. An anion is a negatively charged ion. IEA GO:0008308 voltage-gated anion channel activity GSVIVG01007619001 11172238 11176735 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01007619001 11172238 11176735 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01007619001 11172238 11176735 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01007619001 11172238 11176735 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025126001 4201646 4202347 GSVIVG01016735001 761335 771984 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01016735001 761335 771984 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01016735001 761335 771984 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01016735001 761335 771984 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01016735001 761335 771984 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01016735001 761335 771984 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01015777001 17366989 17383201 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01000282001 2170761 2173434 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01000282001 2170761 2173434 Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium. IEA GO:0005544 calcium-dependent phospholipid binding GSVIVG01013574001 21093927 21098316 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01013574001 21093927 21098316 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01013574001 21093927 21098316 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli. IEA GO:0004707 MAP kinase activity GSVIVG01013574001 21093927 21098316 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01013574001 21093927 21098316 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011962001 2574244 2575738 GSVIVG01034762001 9203835 9205202 GSVIVG01025671001 13063053 13063917 GSVIVG01004631001 39228015 39228314 GSVIVG01002342001 34233125 34236078 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01002342001 34233125 34236078 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024036001 1583962 1585390 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01031532001 17455039 17466035 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. IEA GO:0003743 translation initiation factor activity GSVIVG01031532001 17455039 17466035 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. IEA GO:0003743 translation initiation factor activity GSVIVG01031532001 17455039 17466035 GO:0006413 translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. IEA Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. IEA GO:0003743 translation initiation factor activity GSVIVG01031532001 17455039 17466035 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. IEA GO:0003743 translation initiation factor activity GSVIVG01031532001 17455039 17466035 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031532001 17455039 17466035 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031532001 17455039 17466035 GO:0006413 translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031532001 17455039 17466035 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031532001 17455039 17466035 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01031532001 17455039 17466035 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01031532001 17455039 17466035 GO:0006413 translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01031532001 17455039 17466035 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01031532001 17455039 17466035 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01031532001 17455039 17466035 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01031532001 17455039 17466035 GO:0006413 translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01031532001 17455039 17466035 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01011978001 2465249 2466064 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01030492001 6160917 6161184 GSVIVG01028832001 18275439 18276955 GSVIVG01031147001 1721480 1723373 GSVIVG01018290001 11698737 11704533 GSVIVG01029642001 20279645 20282585 GSVIVG01024200001 376743 380317 GO:0015671 oxygen transport The directed movement of oxygen (O2) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01024200001 376743 380317 GO:0015671 oxygen transport The directed movement of oxygen (O2) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01024200001 376743 380317 GO:0015671 oxygen transport The directed movement of oxygen (O2) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with oxygen (O2). IEA GO:0019825 oxygen binding GSVIVG01024200001 376743 380317 GO:0015671 oxygen transport The directed movement of oxygen (O2) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01029912001 1350177 1387367 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01029912001 1350177 1387367 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01029912001 1350177 1387367 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01029912001 1350177 1387367 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01015190001 1671502 1678203 GSVIVG01032958001 24612252 24616683 GSVIVG01014716001 8934684 8940263 GSVIVG01038712001 20703875 20708561 GSVIVG01018667001 11461653 11464354 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01019666001 2326794 2327833 GSVIVG01024331001 1088101 1096171 GSVIVG01027182001 17211736 17213145 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01004438001 38566736 38570952 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01010331001 19570005 19571923 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01010331001 19570005 19571923 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01024619001 8320480 8332598 GSVIVG01033295001 21758491 21759253 GSVIVG01029699001 13343303 13345211 GSVIVG01023746001 10559929 10560571 GSVIVG01002004001 6198078 6205568 GSVIVG01033393001 20994964 20997432 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033393001 20994964 20997432 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01016563001 2752466 2753909 GSVIVG01033216001 9842033 9842587 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01033216001 9842033 9842587 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01033216001 9842033 9842587 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01033216001 9842033 9842587 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01001144001 23002140 23021474 GSVIVG01009903001 12281621 12286855 GO:0006621 protein retention in ER lumen The retention in the endoplasmic reticulum (ER) lumen of soluble resident proteins. Sorting receptors retrieve proteins with ER localization signals, such as KDEL and HDEL sequences or some transmembrane domains, that have escaped to the cis-Golgi network and return them to the ER. Abnormally folded proteins and unassembled subunits are also selectively retained in the ER. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with an endoplasmic reticulum (ER) retention sequence, a specific peptide sequence that ensures a protein is retained within the ER. IEA GO:0046923 ER retention sequence binding GSVIVG01004855001 110283 113460 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01000545001 7240959 7245308 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01036403001 4685586 4686974 GSVIVG01032083001 22890217 22893126 GSVIVG01024674001 7892669 7896713 GSVIVG01032525001 28078618 28083411 GSVIVG01037661001 6634271 6642457 GSVIVG01035385001 921552 923881 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01035385001 921552 923881 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01003251001 8342641 8350864 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01028868001 17979668 17985100 GSVIVG01008954001 3822867 3829701 GO:0006544 glycine metabolic process The chemical reactions and pathways involving glycine, aminoethanoic acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008954001 3822867 3829701 GO:0006563 L-serine metabolic process The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008954001 3822867 3829701 GO:0006544 glycine metabolic process The chemical reactions and pathways involving glycine, aminoethanoic acid. IEA Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine. IEA GO:0004372 glycine hydroxymethyltransferase activity GSVIVG01008954001 3822867 3829701 GO:0006563 L-serine metabolic process The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. IEA Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine. IEA GO:0004372 glycine hydroxymethyltransferase activity GSVIVG01008954001 3822867 3829701 GO:0006544 glycine metabolic process The chemical reactions and pathways involving glycine, aminoethanoic acid. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01008954001 3822867 3829701 GO:0006563 L-serine metabolic process The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01037331001 15577384 15577585 GSVIVG01030614001 7177304 7178062 GSVIVG01037494001 12691490 12722376 GSVIVG01001136001 22895505 22897007 GSVIVG01016983001 3157343 3165859 GSVIVG01036857001 18715012 18715732 GSVIVG01038238001 24544063 24544794 GO:0042255 ribosome assembly The aggregation, arrangement and bonding together of the mature ribosome and of its subunits. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01038238001 24544063 24544794 GO:0042255 ribosome assembly The aggregation, arrangement and bonding together of the mature ribosome and of its subunits. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01010995001 2351497 2355452 GSVIVG01016743001 869972 870233 GSVIVG01030501001 6247565 6254679 GSVIVG01004023001 1405366 1407740 GSVIVG01003482001 10656114 10656953 GSVIVG01034815001 22002192 22010272 GSVIVG01023788001 3461863 3463814 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01007742001 9687220 9689610 GO:0015976 carbon utilization A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbon sources and then activates genes to scavenge the last traces of the primary carbon source and to transport and metabolize alternative carbon sources such as carbon dioxide or carbonic acid. The utilization process begins when the cell or organism detects carbon levels, includes the activation of genes whose products detect, transport or metabolize carbon-containing substances, and ends when carbon is incorporated into the cell or organism's metabolism. IEA Catalysis of the reaction: H2CO3 = CO2 + H2O. IEA GO:0004089 carbonate dehydratase activity GSVIVG01007742001 9687220 9689610 GO:0015976 carbon utilization A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbon sources and then activates genes to scavenge the last traces of the primary carbon source and to transport and metabolize alternative carbon sources such as carbon dioxide or carbonic acid. The utilization process begins when the cell or organism detects carbon levels, includes the activation of genes whose products detect, transport or metabolize carbon-containing substances, and ends when carbon is incorporated into the cell or organism's metabolism. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01023789001 3457458 3461294 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01023789001 3457458 3461294 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033766001 18011938 18013241 GSVIVG01021012001 15337618 15339863 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01022355001 18933005 18936614 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01012436001 742164 743131 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012436001 742164 743131 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032428001 27308623 27313562 GO:0009236 cobalamin biosynthetic process The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01032428001 27308623 27313562 GO:0009236 cobalamin biosynthetic process The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01010101001 15443313 15464415 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01019478001 970124 974084 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01017172001 4958838 4964241 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01017172001 4958838 4964241 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017172001 4958838 4964241 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01018011001 5444222 5449261 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01018011001 5444222 5449261 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01018011001 5444222 5449261 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate, driving the unwinding of the DNA helix. IEA GO:0004003 ATP-dependent DNA helicase activity GSVIVG01018011001 5444222 5449261 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018011001 5444222 5449261 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01018011001 5444222 5449261 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01003389001 9800782 9816166 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01003389001 9800782 9816166 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01003389001 9800782 9816166 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01022902001 18177896 18178890 Functions in the storage of nutritious substrates. IEA GO:0045735 nutrient reservoir activity GSVIVG01017158001 4850951 4853220 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01017158001 4850951 4853220 GO:0009734 auxin mediated signaling pathway The series of molecular signals generated in response to detection of auxin. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01017158001 4850951 4853220 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01013841001 5117219 5121674 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004197 cysteine-type endopeptidase activity GSVIVG01008242001 4195887 4225096 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01022445001 3123820 3124953 GSVIVG01000568001 6988614 6993527 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01000568001 6988614 6993527 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01009223001 6406367 6411300 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GSVIVG01032361001 26710181 26714666 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01032361001 26710181 26714666 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01032361001 26710181 26714666 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01010217001 17754740 17755128 GSVIVG01004967001 17126759 17128715 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01003217001 14007416 14010547 GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of the reaction: S-adenosyl-L-methionine + [ribulose-1,5-bisphosphate carboxylase]-lysine = S-adenosyl-L-homocysteine + [ribulose-1,5-bisphosphate carboxylase]-N6-methyl-L-lysine. IEA GO:0030785 [ribulose-bisphosphate carboxylase]-lysine N-methyltransferase activity GSVIVG01038760001 610174 641062 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01038760001 610174 641062 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01038760001 610174 641062 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01038760001 610174 641062 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026423001 23723365 23737176 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01026423001 23723365 23737176 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01027527001 15971411 15975216 GSVIVG01012058001 1742013 1746059 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01034165001 14724286 14728264 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01034165001 14724286 14728264 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01034165001 14724286 14728264 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01034165001 14724286 14728264 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025343001 1746652 1768594 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025343001 1746652 1768594 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01025343001 1746652 1768594 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01022899001 18180403 18182225 Functions in the storage of nutritious substrates. IEA GO:0045735 nutrient reservoir activity GSVIVG01023961001 2122899 2124044 GSVIVG01022543001 4579655 4581286 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01022543001 4579655 4581286 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01031723001 3833048 3835366 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01031723001 3833048 3835366 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01031723001 3833048 3835366 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01031723001 3833048 3835366 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01024042001 1534987 1538249 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01024042001 1534987 1538249 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01024042001 1534987 1538249 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01024042001 1534987 1538249 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01036694001 23803974 23806961 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01036694001 23803974 23806961 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01036694001 23803974 23806961 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01033233001 22337789 22340047 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033233001 22337789 22340047 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033233001 22337789 22340047 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033233001 22337789 22340047 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033233001 22337789 22340047 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033233001 22337789 22340047 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033233001 22337789 22340047 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033233001 22337789 22340047 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033233001 22337789 22340047 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033233001 22337789 22340047 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033233001 22337789 22340047 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033233001 22337789 22340047 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033233001 22337789 22340047 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+. IEA GO:0004367 glycerol-3-phosphate dehydrogenase (NAD+) activity GSVIVG01033233001 22337789 22340047 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+. IEA GO:0004367 glycerol-3-phosphate dehydrogenase (NAD+) activity GSVIVG01033233001 22337789 22340047 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+. IEA GO:0004367 glycerol-3-phosphate dehydrogenase (NAD+) activity GSVIVG01033233001 22337789 22340047 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+. IEA GO:0004367 glycerol-3-phosphate dehydrogenase (NAD+) activity GSVIVG01033233001 22337789 22340047 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+. IEA GO:0004367 glycerol-3-phosphate dehydrogenase (NAD+) activity GSVIVG01033233001 22337789 22340047 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+. IEA GO:0004367 glycerol-3-phosphate dehydrogenase (NAD+) activity GSVIVG01033233001 22337789 22340047 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+. IEA GO:0004367 glycerol-3-phosphate dehydrogenase (NAD+) activity GSVIVG01033233001 22337789 22340047 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+. IEA GO:0004367 glycerol-3-phosphate dehydrogenase (NAD+) activity GSVIVG01033233001 22337789 22340047 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+. IEA GO:0004367 glycerol-3-phosphate dehydrogenase (NAD+) activity GSVIVG01033233001 22337789 22340047 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+. IEA GO:0004367 glycerol-3-phosphate dehydrogenase (NAD+) activity GSVIVG01033233001 22337789 22340047 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+. IEA GO:0004367 glycerol-3-phosphate dehydrogenase (NAD+) activity GSVIVG01033233001 22337789 22340047 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+. IEA GO:0004367 glycerol-3-phosphate dehydrogenase (NAD+) activity GSVIVG01033233001 22337789 22340047 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033233001 22337789 22340047 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033233001 22337789 22340047 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033233001 22337789 22340047 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033233001 22337789 22340047 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033233001 22337789 22340047 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033233001 22337789 22340047 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033233001 22337789 22340047 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033233001 22337789 22340047 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033233001 22337789 22340047 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033233001 22337789 22340047 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033233001 22337789 22340047 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033233001 22337789 22340047 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01033233001 22337789 22340047 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01033233001 22337789 22340047 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01033233001 22337789 22340047 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01033233001 22337789 22340047 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01033233001 22337789 22340047 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01033233001 22337789 22340047 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01033233001 22337789 22340047 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01033233001 22337789 22340047 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01033233001 22337789 22340047 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01033233001 22337789 22340047 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01033233001 22337789 22340047 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01033233001 22337789 22340047 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033233001 22337789 22340047 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033233001 22337789 22340047 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033233001 22337789 22340047 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033233001 22337789 22340047 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033233001 22337789 22340047 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033233001 22337789 22340047 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033233001 22337789 22340047 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033233001 22337789 22340047 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033233001 22337789 22340047 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033233001 22337789 22340047 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033233001 22337789 22340047 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033233001 22337789 22340047 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GSVIVG01033233001 22337789 22340047 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GSVIVG01033233001 22337789 22340047 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GSVIVG01033233001 22337789 22340047 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GSVIVG01033233001 22337789 22340047 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GSVIVG01033233001 22337789 22340047 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GSVIVG01033233001 22337789 22340047 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GSVIVG01033233001 22337789 22340047 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GSVIVG01033233001 22337789 22340047 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GSVIVG01033233001 22337789 22340047 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GSVIVG01033233001 22337789 22340047 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GSVIVG01033233001 22337789 22340047 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GSVIVG01033233001 22337789 22340047 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01033233001 22337789 22340047 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01033233001 22337789 22340047 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01033233001 22337789 22340047 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01033233001 22337789 22340047 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01033233001 22337789 22340047 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01033233001 22337789 22340047 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01033233001 22337789 22340047 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01033233001 22337789 22340047 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01033233001 22337789 22340047 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01033233001 22337789 22340047 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01033233001 22337789 22340047 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01033233001 22337789 22340047 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01033233001 22337789 22340047 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01033233001 22337789 22340047 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01033233001 22337789 22340047 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01033233001 22337789 22340047 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01033233001 22337789 22340047 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01033233001 22337789 22340047 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01033233001 22337789 22340047 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01033233001 22337789 22340047 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01033233001 22337789 22340047 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01033233001 22337789 22340047 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01033233001 22337789 22340047 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01033233001 22337789 22340047 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01033233001 22337789 22340047 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01033233001 22337789 22340047 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01033233001 22337789 22340047 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01033233001 22337789 22340047 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01033233001 22337789 22340047 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01033233001 22337789 22340047 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01033233001 22337789 22340047 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01033233001 22337789 22340047 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01033233001 22337789 22340047 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01033233001 22337789 22340047 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01033233001 22337789 22340047 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01026498001 22604957 22630739 GSVIVG01021245001 2926183 2933221 GO:0006353 transcription termination The process by which transcription is completed; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA. IEA Any activity that brings about termination of transcription. IEA GO:0003715 transcription termination factor activity GSVIVG01018833001 19467932 19469492 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01018833001 19467932 19469492 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01018833001 19467932 19469492 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01013948001 7444564 7446944 GSVIVG01029864001 720660 722777 GSVIVG01037529001 12127473 12127667 GSVIVG01011294001 7798070 7798255 GSVIVG01022764001 16244697 16247594 GSVIVG01002725001 36157053 36157160 GSVIVG01016209001 6593309 6603253 GSVIVG01037003001 9072903 9073766 GSVIVG01036181001 19733644 19748098 GSVIVG01025802001 11715074 11728228 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025802001 11715074 11728228 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025802001 11715074 11728228 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01025802001 11715074 11728228 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01025802001 11715074 11728228 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01025802001 11715074 11728228 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01025802001 11715074 11728228 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01025802001 11715074 11728228 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01025802001 11715074 11728228 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025802001 11715074 11728228 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025802001 11715074 11728228 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01025802001 11715074 11728228 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01023168001 21746618 21747003 GSVIVG01026372001 15210734 15213343 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01026372001 15210734 15213343 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01020397001 20132823 20140511 GSVIVG01027909001 9248643 9252854 GO:0007218 neuropeptide signaling pathway The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor. IEA GSVIVG01024255001 264841 269614 GSVIVG01001094001 22609281 22613729 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01036731001 23215254 23216894 GSVIVG01037788001 7871772 7903218 GSVIVG01025085001 4635360 4641294 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01025085001 4635360 4641294 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01025085001 4635360 4641294 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01025085001 4635360 4641294 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038235001 24534831 24536519 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01038235001 24534831 24536519 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01038235001 24534831 24536519 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01038235001 24534831 24536519 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01038235001 24534831 24536519 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01038235001 24534831 24536519 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01038235001 24534831 24536519 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01038235001 24534831 24536519 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01007767001 9255819 9255998 GSVIVG01012145001 1071686 1078368 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012145001 1071686 1078368 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01033946001 16439391 16440485 GSVIVG01004953001 17002148 17002572 GSVIVG01004825001 5471749 5475214 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). IEA GO:0003755 peptidyl-prolyl cis-trans isomerase activity GSVIVG01021661001 8882298 8893394 GSVIVG01015184001 1627852 1633605 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01015184001 1627852 1633605 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01037630001 6349897 6356238 Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum. IEA GO:0003993 acid phosphatase activity GSVIVG01037630001 6349897 6356238 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01037630001 6349897 6356238 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01036170001 19863106 19880866 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01020033001 11304894 11307266 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01020033001 11304894 11307266 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01020033001 11304894 11307266 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01020033001 11304894 11307266 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01020033001 11304894 11307266 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01020033001 11304894 11307266 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01020033001 11304894 11307266 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01020033001 11304894 11307266 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01032694001 1456751 1467068 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01032694001 1456751 1467068 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01032694001 1456751 1467068 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01032694001 1456751 1467068 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01023793001 3430130 3433815 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01023793001 3430130 3433815 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01023793001 3430130 3433815 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01023793001 3430130 3433815 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01023793001 3430130 3433815 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01023793001 3430130 3433815 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01022506001 4105845 4113891 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01022506001 4105845 4113891 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01034655001 13126546 13128411 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01013369001 914534 922269 GSVIVG01018245001 12603621 12605594 GSVIVG01012419001 607459 608477 GSVIVG01020611001 3781637 3784433 GSVIVG01033314001 21586797 21593183 GSVIVG01026877001 19693653 19699787 GSVIVG01032181001 21775649 21777110 GSVIVG01021118001 1617591 1621640 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01021118001 1617591 1621640 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01021118001 1617591 1621640 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01021118001 1617591 1621640 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01021118001 1617591 1621640 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027444001 16684435 16685894 GSVIVG01010080001 14982723 14984281 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01010080001 14982723 14984281 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01010080001 14982723 14984281 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01010080001 14982723 14984281 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01014798001 9922208 9922870 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01015571001 5052418 5071002 GSVIVG01016650001 70509 95429 GO:0016117 carotenoid biosynthetic process The chemical reactions and pathways resulting in the formation of carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01016650001 70509 95429 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01016650001 70509 95429 GO:0016117 carotenoid biosynthetic process The chemical reactions and pathways resulting in the formation of carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016650001 70509 95429 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016650001 70509 95429 GO:0016117 carotenoid biosynthetic process The chemical reactions and pathways resulting in the formation of carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. IEA GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GSVIVG01016650001 70509 95429 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. IEA GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GSVIVG01029631001 20455941 20459385 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01029631001 20455941 20459385 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01032559001 28362335 28369978 GSVIVG01008923001 3417193 3418012 GSVIVG01023655001 8600259 8610458 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01015493001 4185008 4188714 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01000229001 20120667 20122109 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01000229001 20120667 20122109 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01014821001 10156336 10158496 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with transfer RNA. IEA GO:0000049 tRNA binding GSVIVG01014821001 10156336 10158496 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe). IEA GO:0004826 phenylalanine-tRNA ligase activity GSVIVG01014821001 10156336 10158496 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022794001 16675912 16678634 GSVIVG01016404001 4189575 4190057 GSVIVG01002931001 37230097 37234074 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Functions to initiate or regulate RNA polymerase II transcription. IEA GO:0003702 RNA polymerase II transcription factor activity GSVIVG01002931001 37230097 37234074 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Functions to initiate or regulate RNA polymerase II transcription. IEA GO:0003702 RNA polymerase II transcription factor activity GSVIVG01009146001 5498180 5501829 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01009146001 5498180 5501829 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01009146001 5498180 5501829 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009146001 5498180 5501829 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009146001 5498180 5501829 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01009146001 5498180 5501829 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01008964001 3900385 3905806 GSVIVG01001848001 26290387 26292606 GSVIVG01025446001 769137 772933 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of hydroxylation at the 7-methyl group of chlorophyllide a, according to the reactions: chlorophyllide a + O2 + NADPH + H+ = 7-hydroxychlorophyllide a + H2O + NADP+ and 7-hydroxychlorophyllide a + O2 + NADPH + H+ = chlorophyllide b + 2 H2O + NADP+. IEA GO:0010277 chlorophyllide a oxygenase activity GSVIVG01025446001 769137 772933 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025446001 769137 772933 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051537 2 iron, 2 sulfur cluster binding GSVIVG01020665001 3292281 3293351 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020665001 3292281 3293351 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01021494001 6136278 6149695 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021494001 6136278 6149695 Catalysis of the transfer of a functional group from one position to another within a single molecule. IEA GO:0016866 intramolecular transferase activity GSVIVG01009941001 12668323 12671744 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01009941001 12668323 12671744 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01009941001 12668323 12671744 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01009941001 12668323 12671744 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01009941001 12668323 12671744 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011025001 2124263 2127344 GSVIVG01036082001 20917230 20921205 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01036082001 20917230 20921205 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01036082001 20917230 20921205 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01017409001 8104776 8105659 GSVIVG01014522001 4788586 4790378 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014522001 4788586 4790378 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014563001 5188833 5190518 Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01014563001 5188833 5190518 Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01017968001 5145293 5148759 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01017968001 5145293 5148759 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01017968001 5145293 5148759 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01017968001 5145293 5148759 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030661001 13115718 13122838 GSVIVG01012177001 751779 759740 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012177001 751779 759740 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA Catalysis of the hydrolysis of ester linkages within nucleic acids. IEA GO:0004518 nuclease activity GSVIVG01012177001 751779 759740 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01013697001 2753219 2763308 GSVIVG01013559001 20858099 20873278 GSVIVG01003123001 7457726 7481390 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01000001001 2596280 2598951 GSVIVG01029514001 22050177 22067094 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003140001 7577866 7585097 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01003140001 7577866 7585097 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003140001 7577866 7585097 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the reaction: ATP + pyruvate = ADP + phosphoenolpyruvate. IEA GO:0004743 pyruvate kinase activity GSVIVG01003140001 7577866 7585097 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Interacting selectively and non-covalently with potassium (K+) ions. IEA GO:0030955 potassium ion binding GSVIVG01037891001 6642097 6659818 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01036187001 19687654 19693413 GSVIVG01000070001 3211189 3212297 GO:0006566 threonine metabolic process The chemical reactions and pathways involving threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: ATP + L-homoserine = ADP + O-phospho-L-homoserine. IEA GO:0004413 homoserine kinase activity GSVIVG01000070001 3211189 3212297 GO:0006566 threonine metabolic process The chemical reactions and pathways involving threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000070001 3211189 3212297 GO:0006566 threonine metabolic process The chemical reactions and pathways involving threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with manganese (Mn) ions. IEA GO:0030145 manganese ion binding GSVIVG01000070001 3211189 3212297 GO:0006566 threonine metabolic process The chemical reactions and pathways involving threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Functions in the storage of nutritious substrates. IEA GO:0045735 nutrient reservoir activity GSVIVG01000070001 3211189 3212297 GO:0006566 threonine metabolic process The chemical reactions and pathways involving threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01012739001 1133842 1137957 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01012739001 1133842 1137957 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01012739001 1133842 1137957 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01012739001 1133842 1137957 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01009529001 9085913 9091154 GSVIVG01003264001 8553856 8554247 GSVIVG01021840001 6636827 6639143 GSVIVG01001292001 5105826 5110126 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01016944001 2831371 2832519 GSVIVG01023645001 8387424 8396786 GSVIVG01009940001 12645229 12650755 GSVIVG01002450001 34806780 34813910 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01008436001 2054239 2088910 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01008436001 2054239 2088910 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01008436001 2054239 2088910 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01008436001 2054239 2088910 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01008436001 2054239 2088910 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015024001 532570 538242 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01015024001 532570 538242 Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01015024001 532570 538242 Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051537 2 iron, 2 sulfur cluster binding GSVIVG01016943001 2824374 2827869 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01016943001 2824374 2827869 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01016943001 2824374 2827869 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01016943001 2824374 2827869 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016943001 2824374 2827869 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035074001 1301718 1302621 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GSVIVG01035074001 1301718 1302621 GO:0009607 response to biotic stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism. IEA GSVIVG01011719001 4790431 4792324 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GSVIVG01011719001 4790431 4792324 GO:0009607 response to biotic stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism. IEA GSVIVG01036259001 7902644 7911651 GO:0006189 'de novo' IMP biosynthetic process The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate. IEA Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO2. IEA GO:0004638 phosphoribosylaminoimidazole carboxylase activity GSVIVG01034496001 20331033 20346348 GO:0000105 histidine biosynthetic process The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01034496001 20331033 20346348 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01034496001 20331033 20346348 GO:0000105 histidine biosynthetic process The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. IEA Catalysis of the reaction: L-histidinol-phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. IEA GO:0004400 histidinol-phosphate transaminase activity GSVIVG01034496001 20331033 20346348 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: L-histidinol-phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. IEA GO:0004400 histidinol-phosphate transaminase activity GSVIVG01034496001 20331033 20346348 GO:0000105 histidine biosynthetic process The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. IEA Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). IEA GO:0016769 transferase activity, transferring nitrogenous groups GSVIVG01034496001 20331033 20346348 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). IEA GO:0016769 transferase activity, transferring nitrogenous groups GSVIVG01034496001 20331033 20346348 GO:0000105 histidine biosynthetic process The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. IEA Catalysis of the reaction: S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + methylthioadenosine. IEA GO:0016847 1-aminocyclopropane-1-carboxylate synthase activity GSVIVG01034496001 20331033 20346348 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + methylthioadenosine. IEA GO:0016847 1-aminocyclopropane-1-carboxylate synthase activity GSVIVG01034496001 20331033 20346348 GO:0000105 histidine biosynthetic process The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01034496001 20331033 20346348 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01033419001 20856660 20861119 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01033419001 20856660 20861119 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01033419001 20856660 20861119 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015935 small ribosomal subunit The smaller of the two subunits of a ribosome. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01033419001 20856660 20861119 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01033419001 20856660 20861119 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01033419001 20856660 20861119 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015935 small ribosomal subunit The smaller of the two subunits of a ribosome. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01024499001 3352669 3353354 GSVIVG01014258001 2065687 2074580 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01014258001 2065687 2074580 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01018412001 9414869 9418626 GSVIVG01036557001 23425743 23428799 GO:0007047 cellular cell wall organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA Catalysis of the reaction: UDP-glucose + glycogenin = UDP + glucosylglycogenin. IEA GO:0008466 glycogenin glucosyltransferase activity GSVIVG01036557001 23425743 23428799 GO:0007047 cellular cell wall organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. IEA GO:0009505 plant-type cell wall A more or less rigid stucture lying outside the cell membrane of a cell and composed of cellulose and pectin and other organic and inorganic substances. IEA Catalysis of the reaction: UDP-glucose + glycogenin = UDP + glucosylglycogenin. IEA GO:0008466 glycogenin glucosyltransferase activity GSVIVG01036557001 23425743 23428799 GO:0007047 cellular cell wall organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. IEA GO:0030054 cell junction A plasma membrane part that forms a specialized region of connection between two cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix. IEA Catalysis of the reaction: UDP-glucose + glycogenin = UDP + glucosylglycogenin. IEA GO:0008466 glycogenin glucosyltransferase activity GSVIVG01036557001 23425743 23428799 GO:0030244 cellulose biosynthetic process The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA Catalysis of the reaction: UDP-glucose + glycogenin = UDP + glucosylglycogenin. IEA GO:0008466 glycogenin glucosyltransferase activity GSVIVG01036557001 23425743 23428799 GO:0030244 cellulose biosynthetic process The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation. IEA GO:0009505 plant-type cell wall A more or less rigid stucture lying outside the cell membrane of a cell and composed of cellulose and pectin and other organic and inorganic substances. IEA Catalysis of the reaction: UDP-glucose + glycogenin = UDP + glucosylglycogenin. IEA GO:0008466 glycogenin glucosyltransferase activity GSVIVG01036557001 23425743 23428799 GO:0030244 cellulose biosynthetic process The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation. IEA GO:0030054 cell junction A plasma membrane part that forms a specialized region of connection between two cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix. IEA Catalysis of the reaction: UDP-glucose + glycogenin = UDP + glucosylglycogenin. IEA GO:0008466 glycogenin glucosyltransferase activity GSVIVG01036557001 23425743 23428799 GO:0007047 cellular cell wall organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01036557001 23425743 23428799 GO:0007047 cellular cell wall organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. IEA GO:0009505 plant-type cell wall A more or less rigid stucture lying outside the cell membrane of a cell and composed of cellulose and pectin and other organic and inorganic substances. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01036557001 23425743 23428799 GO:0007047 cellular cell wall organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. IEA GO:0030054 cell junction A plasma membrane part that forms a specialized region of connection between two cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01036557001 23425743 23428799 GO:0030244 cellulose biosynthetic process The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01036557001 23425743 23428799 GO:0030244 cellulose biosynthetic process The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation. IEA GO:0009505 plant-type cell wall A more or less rigid stucture lying outside the cell membrane of a cell and composed of cellulose and pectin and other organic and inorganic substances. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01036557001 23425743 23428799 GO:0030244 cellulose biosynthetic process The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation. IEA GO:0030054 cell junction A plasma membrane part that forms a specialized region of connection between two cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01007026001 29787983 29796239 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01007026001 29787983 29796239 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01007026001 29787983 29796239 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007026001 29787983 29796239 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023917001 2502521 2505976 GSVIVG01021103001 1466921 1470752 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01031484001 18078299 18079171 GSVIVG01013790001 7552215 7562392 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01013790001 7552215 7562392 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01013790001 7552215 7562392 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01013790001 7552215 7562392 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01013790001 7552215 7562392 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01013790001 7552215 7562392 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01013790001 7552215 7562392 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01013790001 7552215 7562392 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01005254001 19900743 19901734 GSVIVG01015953001 16096726 16101724 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015953001 16096726 16101724 GO:0006284 base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015953001 16096726 16101724 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the hydrolysis of alkylated DNA; only recognizes and removes the alkylated base 3-methyladenine by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site. IEA GO:0008725 DNA-3-methyladenine glycosylase I activity GSVIVG01015953001 16096726 16101724 GO:0006284 base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. IEA Catalysis of the hydrolysis of alkylated DNA; only recognizes and removes the alkylated base 3-methyladenine by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site. IEA GO:0008725 DNA-3-methyladenine glycosylase I activity GSVIVG01034122001 15011551 15016389 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01034122001 15011551 15016389 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01034122001 15011551 15016389 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01034122001 15011551 15016389 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01034122001 15011551 15016389 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011343001 9041598 9045275 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01029237001 18171868 18197209 GO:0007010 cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01006232001 23809344 23811612 GSVIVG01014607001 5563131 5626881 GSVIVG01034318001 14813073 14813479 GSVIVG01031154001 1664971 1666974 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01021218001 2636699 2646850 GSVIVG01031962001 5738845 5760758 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01031962001 5738845 5760758 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01031962001 5738845 5760758 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01031962001 5738845 5760758 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019998001 11816251 11817813 GSVIVG01003994001 14140725 14144414 GSVIVG01036918001 17631656 17646964 GSVIVG01036568001 23573187 23576046 GSVIVG01018613001 12208841 12231095 GSVIVG01029278001 17662389 17664208 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033428001 20792441 20812797 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01027576001 15432399 15432674 GSVIVG01024182001 531692 533479 GSVIVG01007737001 9720550 9722116 GSVIVG01005577001 40683665 40685282 GSVIVG01011139001 7114723 7116315 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01011139001 7114723 7116315 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033180001 9035778 9036847 GSVIVG01036075001 21022120 21025800 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. IEA GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GSVIVG01008042001 6379499 6387517 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01008042001 6379499 6387517 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008042001 6379499 6387517 Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01008042001 6379499 6387517 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01037475001 13012795 13016430 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01037475001 13012795 13016430 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01037475001 13012795 13016430 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037475001 13012795 13016430 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037475001 13012795 13016430 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01037475001 13012795 13016430 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01031362001 23776 26530 GSVIVG01036688001 23841502 23845561 GSVIVG01031130001 1885515 1887992 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01031130001 1885515 1887992 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01020235001 8712008 8728580 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01036593001 18797445 18798193 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01036593001 18797445 18798193 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036593001 18797445 18798193 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01030317001 9018320 9020094 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01030317001 9018320 9020094 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA A ligand-dependent receptor found in the nucleus of the cell. IEA GO:0004879 ligand-dependent nuclear receptor activity GSVIVG01012684001 634034 638859 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005764 lysosome A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01012684001 634034 638859 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA GO:0005764 lysosome A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01012684001 634034 638859 GO:0006665 sphingolipid metabolic process The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). IEA GO:0005764 lysosome A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01015998001 17125246 17146933 GSVIVG01021715001 9950134 9951741 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021715001 9950134 9951741 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021715001 9950134 9951741 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01021715001 9950134 9951741 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01037653001 6579960 6581211 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. IEA GO:0003743 translation initiation factor activity GSVIVG01037653001 6579960 6581211 GO:0006413 translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. IEA Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. IEA GO:0003743 translation initiation factor activity GSVIVG01034828001 22271554 22273738 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01034828001 22271554 22273738 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01034828001 22271554 22273738 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01034828001 22271554 22273738 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01034828001 22271554 22273738 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01034828001 22271554 22273738 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01032902001 23956348 23965078 GSVIVG01012239001 297105 301979 Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01024230001 84268 93766 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01015117001 1158864 1160585 GSVIVG01030019001 8967099 8974500 GSVIVG01007521001 12806852 12811985 GO:0006006 glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007521001 12806852 12811985 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007521001 12806852 12811985 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007521001 12806852 12811985 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007521001 12806852 12811985 GO:0006006 glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. IEA Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+. IEA GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity GSVIVG01007521001 12806852 12811985 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+. IEA GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity GSVIVG01007521001 12806852 12811985 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+. IEA GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity GSVIVG01007521001 12806852 12811985 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+. IEA GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity GSVIVG01007521001 12806852 12811985 GO:0006006 glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01007521001 12806852 12811985 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01007521001 12806852 12811985 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01007521001 12806852 12811985 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01007521001 12806852 12811985 GO:0006006 glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01007521001 12806852 12811985 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01007521001 12806852 12811985 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01007521001 12806852 12811985 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01007521001 12806852 12811985 GO:0006006 glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. IEA Catalysis of the reaction: glyceraldehyde 3-phosphate + (phosphate / H2O) + NAD(P)+ = (3-phospho-D-glyceroyl-phosphate / 3-phospho-D-glycerate) + NAD(P)H + H+. IEA GO:0008943 glyceraldehyde-3-phosphate dehydrogenase activity GSVIVG01007521001 12806852 12811985 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the reaction: glyceraldehyde 3-phosphate + (phosphate / H2O) + NAD(P)+ = (3-phospho-D-glyceroyl-phosphate / 3-phospho-D-glycerate) + NAD(P)H + H+. IEA GO:0008943 glyceraldehyde-3-phosphate dehydrogenase activity GSVIVG01007521001 12806852 12811985 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: glyceraldehyde 3-phosphate + (phosphate / H2O) + NAD(P)+ = (3-phospho-D-glyceroyl-phosphate / 3-phospho-D-glycerate) + NAD(P)H + H+. IEA GO:0008943 glyceraldehyde-3-phosphate dehydrogenase activity GSVIVG01007521001 12806852 12811985 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: glyceraldehyde 3-phosphate + (phosphate / H2O) + NAD(P)+ = (3-phospho-D-glyceroyl-phosphate / 3-phospho-D-glycerate) + NAD(P)H + H+. IEA GO:0008943 glyceraldehyde-3-phosphate dehydrogenase activity GSVIVG01007521001 12806852 12811985 GO:0006006 glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01007521001 12806852 12811985 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01007521001 12806852 12811985 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01007521001 12806852 12811985 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01007521001 12806852 12811985 GO:0006006 glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01007521001 12806852 12811985 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01007521001 12806852 12811985 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01007521001 12806852 12811985 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01009517001 9009153 9010426 GSVIVG01029336001 14575746 14577071 GSVIVG01024796001 6873193 6876358 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01009447001 8429672 8444912 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01009447001 8429672 8444912 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate. IEA GO:0003774 motor activity GSVIVG01009447001 8429672 8444912 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01009447001 8429672 8444912 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014405001 3429278 3430978 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01010903001 15949031 15949987 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01010903001 15949031 15949987 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01010903001 15949031 15949987 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015935 small ribosomal subunit The smaller of the two subunits of a ribosome. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01037681001 6813688 6814653 GSVIVG01025461001 672384 673196 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025461001 672384 673196 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01012446001 911014 912555 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01012446001 911014 912555 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01012446001 911014 912555 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01012446001 911014 912555 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021837001 6670890 6677349 GSVIVG01022078001 16405608 16412057 GSVIVG01035912001 5714446 5716985 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor). IEA GO:0004659 prenyltransferase activity GSVIVG01029178001 18933627 18934677 GO:0030418 nicotianamine biosynthetic process The chemical reactions and pathways resulting in the formation of nicotianamine, 2(S),3'2(S),3''(S)-N-(N-(3-amino-3-carboxypropyl)-3-amino-3-carboxypropyl)-azetidine-2-carboxylic acid. IEA GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA Catalysis of the reaction: 3 S-adenosyl-L-methionine = 3 5'-S-methyl-5'-thioadenosine + nicotianamine. IEA GO:0030410 nicotianamine synthase activity GSVIVG01003037001 37583029 37583377 GSVIVG01037210001 27952657 27956129 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01037210001 27952657 27956129 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01022000001 4490382 4494054 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01022000001 4490382 4494054 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01022000001 4490382 4494054 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022000001 4490382 4494054 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022000001 4490382 4494054 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01022000001 4490382 4494054 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01001997001 6158351 6161987 GO:0006568 tryptophan metabolic process The chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001997001 6158351 6161987 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001997001 6158351 6161987 GO:0006568 tryptophan metabolic process The chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid. IEA Catalysis of the reaction: L-serine + 1-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H2O. IEA GO:0004834 tryptophan synthase activity GSVIVG01001997001 6158351 6161987 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: L-serine + 1-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H2O. IEA GO:0004834 tryptophan synthase activity GSVIVG01001997001 6158351 6161987 GO:0006568 tryptophan metabolic process The chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01001997001 6158351 6161987 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01008801001 2227632 2229602 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008801001 2227632 2229602 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009535 chloroplast thylakoid membrane The pigmented membrane of a chloroplast thylakoid. An example of this component is found in Arabidopsis thaliana. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008801001 2227632 2229602 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008801001 2227632 2229602 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009579 thylakoid A membranous cellular structure that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the plasma membrane. In eukaryotes they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008801001 2227632 2229602 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008801001 2227632 2229602 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule. IEA GO:0016655 oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor GSVIVG01008801001 2227632 2229602 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009535 chloroplast thylakoid membrane The pigmented membrane of a chloroplast thylakoid. An example of this component is found in Arabidopsis thaliana. IEA Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule. IEA GO:0016655 oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor GSVIVG01008801001 2227632 2229602 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule. IEA GO:0016655 oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor GSVIVG01008801001 2227632 2229602 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009579 thylakoid A membranous cellular structure that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the plasma membrane. In eukaryotes they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation. IEA Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule. IEA GO:0016655 oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor GSVIVG01008801001 2227632 2229602 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule. IEA GO:0016655 oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor GSVIVG01008801001 2227632 2229602 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Interacting selectively and non-covalently with a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds. IEA GO:0048038 quinone binding GSVIVG01008801001 2227632 2229602 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009535 chloroplast thylakoid membrane The pigmented membrane of a chloroplast thylakoid. An example of this component is found in Arabidopsis thaliana. IEA Interacting selectively and non-covalently with a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds. IEA GO:0048038 quinone binding GSVIVG01008801001 2227632 2229602 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Interacting selectively and non-covalently with a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds. IEA GO:0048038 quinone binding GSVIVG01008801001 2227632 2229602 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009579 thylakoid A membranous cellular structure that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the plasma membrane. In eukaryotes they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation. IEA Interacting selectively and non-covalently with a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds. IEA GO:0048038 quinone binding GSVIVG01008801001 2227632 2229602 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds. IEA GO:0048038 quinone binding GSVIVG01025413001 993635 995157 GO:0006869 lipid transport The directed movement of lipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Interacting selectively and non-covalently with a lipid. IEA GO:0008289 lipid binding GSVIVG01010357001 19756001 19763729 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01010357001 19756001 19763729 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010357001 19756001 19763729 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01014633001 8023417 8033145 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01014633001 8023417 8033145 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01014633001 8023417 8033145 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014633001 8023417 8033145 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014633001 8023417 8033145 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01014633001 8023417 8033145 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01014633001 8023417 8033145 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01014633001 8023417 8033145 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01014633001 8023417 8033145 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01014633001 8023417 8033145 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01027036001 18436986 18440109 GSVIVG01015338001 2786883 2801547 GO:0001932 regulation of protein amino acid phosphorylation Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein. IEA GO:0005952 cAMP-dependent protein kinase complex An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015338001 2786883 2801547 GO:0001932 regulation of protein amino acid phosphorylation Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015338001 2786883 2801547 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005952 cAMP-dependent protein kinase complex An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015338001 2786883 2801547 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015338001 2786883 2801547 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0005952 cAMP-dependent protein kinase complex An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015338001 2786883 2801547 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015338001 2786883 2801547 GO:0001932 regulation of protein amino acid phosphorylation Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein. IEA GO:0005952 cAMP-dependent protein kinase complex An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01015338001 2786883 2801547 GO:0001932 regulation of protein amino acid phosphorylation Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01015338001 2786883 2801547 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005952 cAMP-dependent protein kinase complex An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01015338001 2786883 2801547 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01015338001 2786883 2801547 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0005952 cAMP-dependent protein kinase complex An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01015338001 2786883 2801547 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01015338001 2786883 2801547 GO:0001932 regulation of protein amino acid phosphorylation Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein. IEA GO:0005952 cAMP-dependent protein kinase complex An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01015338001 2786883 2801547 GO:0001932 regulation of protein amino acid phosphorylation Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01015338001 2786883 2801547 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005952 cAMP-dependent protein kinase complex An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01015338001 2786883 2801547 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01015338001 2786883 2801547 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0005952 cAMP-dependent protein kinase complex An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01015338001 2786883 2801547 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01015338001 2786883 2801547 GO:0001932 regulation of protein amino acid phosphorylation Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein. IEA GO:0005952 cAMP-dependent protein kinase complex An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer. IEA Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. IEA GO:0004722 protein serine/threonine phosphatase activity GSVIVG01015338001 2786883 2801547 GO:0001932 regulation of protein amino acid phosphorylation Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. IEA GO:0004722 protein serine/threonine phosphatase activity GSVIVG01015338001 2786883 2801547 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005952 cAMP-dependent protein kinase complex An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer. IEA Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. IEA GO:0004722 protein serine/threonine phosphatase activity GSVIVG01015338001 2786883 2801547 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. IEA GO:0004722 protein serine/threonine phosphatase activity GSVIVG01015338001 2786883 2801547 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0005952 cAMP-dependent protein kinase complex An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer. IEA Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. IEA GO:0004722 protein serine/threonine phosphatase activity GSVIVG01015338001 2786883 2801547 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. IEA GO:0004722 protein serine/threonine phosphatase activity GSVIVG01015338001 2786883 2801547 GO:0001932 regulation of protein amino acid phosphorylation Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein. IEA GO:0005952 cAMP-dependent protein kinase complex An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015338001 2786883 2801547 GO:0001932 regulation of protein amino acid phosphorylation Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015338001 2786883 2801547 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005952 cAMP-dependent protein kinase complex An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015338001 2786883 2801547 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015338001 2786883 2801547 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0005952 cAMP-dependent protein kinase complex An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015338001 2786883 2801547 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015338001 2786883 2801547 GO:0001932 regulation of protein amino acid phosphorylation Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein. IEA GO:0005952 cAMP-dependent protein kinase complex An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer. IEA Modulation of the activity of the enzyme cAMP-dependent protein kinase. IEA GO:0008603 cAMP-dependent protein kinase regulator activity GSVIVG01015338001 2786883 2801547 GO:0001932 regulation of protein amino acid phosphorylation Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Modulation of the activity of the enzyme cAMP-dependent protein kinase. IEA GO:0008603 cAMP-dependent protein kinase regulator activity GSVIVG01015338001 2786883 2801547 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005952 cAMP-dependent protein kinase complex An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer. IEA Modulation of the activity of the enzyme cAMP-dependent protein kinase. IEA GO:0008603 cAMP-dependent protein kinase regulator activity GSVIVG01015338001 2786883 2801547 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Modulation of the activity of the enzyme cAMP-dependent protein kinase. IEA GO:0008603 cAMP-dependent protein kinase regulator activity GSVIVG01015338001 2786883 2801547 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0005952 cAMP-dependent protein kinase complex An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer. IEA Modulation of the activity of the enzyme cAMP-dependent protein kinase. IEA GO:0008603 cAMP-dependent protein kinase regulator activity GSVIVG01015338001 2786883 2801547 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Modulation of the activity of the enzyme cAMP-dependent protein kinase. IEA GO:0008603 cAMP-dependent protein kinase regulator activity GSVIVG01022474001 3489938 3492369 GSVIVG01016482001 3491589 3493349 GSVIVG01004129001 15145438 15146445 GSVIVG01017704001 2791465 2791901 GSVIVG01027487001 16400961 16407013 GSVIVG01007983001 6971152 6972402 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017808001 3615706 3618981 GO:0000272 polysaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01017808001 3615706 3618981 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01017808001 3615706 3618981 GO:0000272 polysaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages. IEA Catalysis of the hydrolysis of 1,4-alpha-glucosidic linkages in polysaccharides so as to remove successive maltose units from the non-reducing ends of the chains. IEA GO:0016161 beta-amylase activity GSVIVG01017808001 3615706 3618981 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of 1,4-alpha-glucosidic linkages in polysaccharides so as to remove successive maltose units from the non-reducing ends of the chains. IEA GO:0016161 beta-amylase activity GSVIVG01017808001 3615706 3618981 GO:0000272 polysaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01017808001 3615706 3618981 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01025180001 3648407 3651738 GSVIVG01024967001 5629088 5630271 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01006630001 27153981 27155446 GSVIVG01029065001 11754228 11759310 GSVIVG01018772001 20077077 20079876 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0042651 thylakoid membrane The pigmented membrane of any thylakoid. IEA Catalysis of the reaction: reduced ferredoxin + NADP+ = oxidized ferredoxin + NADPH + H+. IEA GO:0004324 ferredoxin-NADP+ reductase activity GSVIVG01018772001 20077077 20079876 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0042651 thylakoid membrane The pigmented membrane of any thylakoid. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01018772001 20077077 20079876 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0042651 thylakoid membrane The pigmented membrane of any thylakoid. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01018772001 20077077 20079876 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0042651 thylakoid membrane The pigmented membrane of any thylakoid. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01003150001 6212206 6214061 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003150001 6212206 6214061 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003150001 6212206 6214061 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01003150001 6212206 6214061 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01003150001 6212206 6214061 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01003150001 6212206 6214061 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01003150001 6212206 6214061 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01003150001 6212206 6214061 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021828001 6796901 6798234 GO:0009052 pentose-phosphate shunt, non-oxidative branch The branch of the pentose-phosphate shunt which does not involve oxidation reactions. It comprises a series of sugar phosphate interconversions, starting with ribulose 5-P and producing fructose 6-P and glyceraldehyde 3-P. IEA Catalysis of the reaction: D-ribose 5-phosphate = D-ribulose 5-phosphate. IEA GO:0004751 ribose-5-phosphate isomerase activity GSVIVG01035118001 1581335 1592577 GSVIVG01032479001 27776087 27779862 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032479001 27776087 27779862 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032479001 27776087 27779862 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032479001 27776087 27779862 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032479001 27776087 27779862 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01032479001 27776087 27779862 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01032479001 27776087 27779862 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01032479001 27776087 27779862 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01032479001 27776087 27779862 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. IEA GO:0048037 cofactor binding GSVIVG01032479001 27776087 27779862 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. IEA GO:0048037 cofactor binding GSVIVG01032479001 27776087 27779862 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01032479001 27776087 27779862 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01006975001 29515855 29517910 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01006975001 29515855 29517910 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01003942001 8230891 8233109 GSVIVG01030386001 5132775 5136194 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030386001 5132775 5136194 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030386001 5132775 5136194 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030386001 5132775 5136194 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01030386001 5132775 5136194 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01030386001 5132775 5136194 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01030386001 5132775 5136194 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01030386001 5132775 5136194 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01030386001 5132775 5136194 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01030386001 5132775 5136194 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01030386001 5132775 5136194 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01030386001 5132775 5136194 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01030386001 5132775 5136194 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: chlorophyllide A + NADP+ = protochlorophyllide + NADPH + H+. IEA GO:0016630 protochlorophyllide reductase activity GSVIVG01030386001 5132775 5136194 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: chlorophyllide A + NADP+ = protochlorophyllide + NADPH + H+. IEA GO:0016630 protochlorophyllide reductase activity GSVIVG01030386001 5132775 5136194 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: chlorophyllide A + NADP+ = protochlorophyllide + NADPH + H+. IEA GO:0016630 protochlorophyllide reductase activity GSVIVG01021960001 5074158 5074570 GSVIVG01010769001 22424480 22433673 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01010769001 22424480 22433673 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01010769001 22424480 22433673 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01010769001 22424480 22433673 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010769001 22424480 22433673 Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01010769001 22424480 22433673 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01011279001 10460014 10484163 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005773 vacuole A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol. IEA Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain. IEA GO:0004177 aminopeptidase activity GSVIVG01011279001 10460014 10484163 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005773 vacuole A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01011279001 10460014 10484163 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005773 vacuole A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol. IEA Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008237 metallopeptidase activity GSVIVG01011279001 10460014 10484163 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005773 vacuole A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01011279001 10460014 10484163 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005773 vacuole A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01011279001 10460014 10484163 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005773 vacuole A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01008893001 3209032 3213914 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008237 metallopeptidase activity GSVIVG01008893001 3209032 3213914 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008237 metallopeptidase activity GSVIVG01008893001 3209032 3213914 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01008893001 3209032 3213914 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01035573001 2404931 2406318 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01035573001 2404931 2406318 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01014539001 4954907 4956200 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01035880001 5206353 5210218 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01003980001 26444589 26452290 GSVIVG01034216001 12865807 12866993 GSVIVG01033239001 22271506 22277684 GO:0005759 mitochondrial matrix The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. IEA GSVIVG01037038001 8654173 8655019 GSVIVG01031563001 18212947 18213720 GSVIVG01028708001 19568865 19573229 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01028708001 19568865 19573229 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01028249001 4918598 4937173 GO:0006605 protein targeting The process of targeting specific proteins to particular membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01028249001 4918598 4937173 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01028249001 4918598 4937173 GO:0017038 protein import The directed movement of proteins into a cell or organelle. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01028249001 4918598 4937173 GO:0006605 protein targeting The process of targeting specific proteins to particular membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01028249001 4918598 4937173 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01028249001 4918598 4937173 GO:0017038 protein import The directed movement of proteins into a cell or organelle. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01028249001 4918598 4937173 GO:0006605 protein targeting The process of targeting specific proteins to particular membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01028249001 4918598 4937173 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01028249001 4918598 4937173 GO:0017038 protein import The directed movement of proteins into a cell or organelle. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01028249001 4918598 4937173 GO:0006605 protein targeting The process of targeting specific proteins to particular membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028249001 4918598 4937173 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028249001 4918598 4937173 GO:0017038 protein import The directed movement of proteins into a cell or organelle. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033808001 17614517 17618512 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01025052001 4978367 4980438 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025052001 4978367 4980438 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025052001 4978367 4980438 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025052001 4978367 4980438 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01025052001 4978367 4980438 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01025052001 4978367 4980438 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01025052001 4978367 4980438 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01025052001 4978367 4980438 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01025052001 4978367 4980438 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01033654001 18905463 18907683 GSVIVG01012987001 10594831 10608680 Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01020231001 8807197 8810280 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other. IEA GO:0005337 nucleoside transmembrane transporter activity GSVIVG01037848001 7149870 7160655 GSVIVG01007280001 31237142 31240874 GSVIVG01035971001 6654258 6654769 GSVIVG01020043001 11224676 11229121 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01021050001 14591199 14603052 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01000297001 2625028 2625460 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01009232001 6487456 6491941 GSVIVG01028673001 11933103 11952123 GSVIVG01008820001 2450413 2454610 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01008820001 2450413 2454610 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01038607001 21532535 21537566 GO:0007034 vacuolar transport The directed movement of substances into, out of or within a vacuole. IEA GO:0030904 retromer complex A conserved multimeric membrane-associated complex involved in retrograde transport from endosomes to the Golgi apparatus. For example, the budding yeast retromer comprises Vps35p, Vps29p, Vps26p, Vps5p, and Vps17p. IEA GSVIVG01013273001 5798022 5798307 GSVIVG01037136001 28749592 28756756 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01037136001 28749592 28756756 GO:0009725 response to hormone stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01037136001 28749592 28756756 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01037136001 28749592 28756756 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01037136001 28749592 28756756 GO:0009725 response to hormone stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01037136001 28749592 28756756 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01018029001 5650420 5653062 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01018029001 5650420 5653062 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01018029001 5650420 5653062 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01018029001 5650420 5653062 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01018029001 5650420 5653062 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01018029001 5650420 5653062 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01018029001 5650420 5653062 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01018029001 5650420 5653062 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01018029001 5650420 5653062 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01018029001 5650420 5653062 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01018029001 5650420 5653062 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01018029001 5650420 5653062 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01027659001 14551055 14555820 GSVIVG01015780001 17428662 17429476 GSVIVG01024139001 856872 857987 GSVIVG01034034001 15687965 15692856 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the removal of a phosphate group from phosphorylated myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol. IEA GO:0004437 inositol or phosphatidylinositol phosphatase activity GSVIVG01034034001 15687965 15692856 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3. IEA GO:0042578 phosphoric ester hydrolase activity GSVIVG01025500001 300269 307086 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01000646001 20344472 20364815 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000646001 20344472 20364815 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000646001 20344472 20364815 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000646001 20344472 20364815 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015569001 5028789 5036603 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01015569001 5028789 5036603 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01015569001 5028789 5036603 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01001850001 26293468 26297939 GSVIVG01013705001 2829153 2832669 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01013705001 2829153 2832669 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01013705001 2829153 2832669 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01013705001 2829153 2832669 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013705001 2829153 2832669 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020648001 3474790 3481983 GSVIVG01007431001 31840889 31841696 GSVIVG01037760001 7640416 7641515 GSVIVG01001173001 1072564 1074764 GSVIVG01006394001 25596029 25596518 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01006394001 25596029 25596518 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01006394001 25596029 25596518 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01006394001 25596029 25596518 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01006394001 25596029 25596518 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01006394001 25596029 25596518 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01016008001 17270359 17270534 GSVIVG01031232001 1007040 1010126 GO:0006415 translational termination The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code). IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Involved in catalyzing the release of a nascent polypeptide chain from a ribosome. IEA GO:0003747 translation release factor activity GSVIVG01031232001 1007040 1010126 GO:0006415 translational termination The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code). IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA A translation release factor that is specific for one or more particular termination codons; acts at the ribosomal A-site and require polypeptidyl-tRNA at the P-site. IEA GO:0016149 translation release factor activity, codon specific GSVIVG01023787001 3468312 3475880 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01023787001 3468312 3475880 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01023787001 3468312 3475880 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01023787001 3468312 3475880 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01030793001 16192407 16195975 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01030793001 16192407 16195975 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01030793001 16192407 16195975 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01030793001 16192407 16195975 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030793001 16192407 16195975 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007952001 7239172 7243130 GSVIVG01003173001 5989504 5993941 GSVIVG01024174001 593088 594606 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024174001 593088 594606 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024174001 593088 594606 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the reaction: D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate. IEA GO:0004332 fructose-bisphosphate aldolase activity GSVIVG01024174001 593088 594606 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate. IEA GO:0004332 fructose-bisphosphate aldolase activity GSVIVG01015895001 19020232 19021653 GO:0006869 lipid transport The directed movement of lipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01015895001 19020232 19021653 GO:0006869 lipid transport The directed movement of lipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01015895001 19020232 19021653 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01015895001 19020232 19021653 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01015895001 19020232 19021653 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01015895001 19020232 19021653 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01015895001 19020232 19021653 GO:0006869 lipid transport The directed movement of lipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA The action of a molecule that contributes to the structural integrity of a cell wall. IEA GO:0005199 structural constituent of cell wall GSVIVG01015895001 19020232 19021653 GO:0006869 lipid transport The directed movement of lipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The action of a molecule that contributes to the structural integrity of a cell wall. IEA GO:0005199 structural constituent of cell wall GSVIVG01015895001 19020232 19021653 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA The action of a molecule that contributes to the structural integrity of a cell wall. IEA GO:0005199 structural constituent of cell wall GSVIVG01015895001 19020232 19021653 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The action of a molecule that contributes to the structural integrity of a cell wall. IEA GO:0005199 structural constituent of cell wall GSVIVG01015895001 19020232 19021653 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA The action of a molecule that contributes to the structural integrity of a cell wall. IEA GO:0005199 structural constituent of cell wall GSVIVG01015895001 19020232 19021653 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The action of a molecule that contributes to the structural integrity of a cell wall. IEA GO:0005199 structural constituent of cell wall GSVIVG01024348001 1288285 1291078 GSVIVG01000067001 3199243 3200255 GO:0006566 threonine metabolic process The chemical reactions and pathways involving threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: ATP + L-homoserine = ADP + O-phospho-L-homoserine. IEA GO:0004413 homoserine kinase activity GSVIVG01000067001 3199243 3200255 GO:0006566 threonine metabolic process The chemical reactions and pathways involving threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000067001 3199243 3200255 GO:0006566 threonine metabolic process The chemical reactions and pathways involving threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with manganese (Mn) ions. IEA GO:0030145 manganese ion binding GSVIVG01000067001 3199243 3200255 GO:0006566 threonine metabolic process The chemical reactions and pathways involving threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Functions in the storage of nutritious substrates. IEA GO:0045735 nutrient reservoir activity GSVIVG01000067001 3199243 3200255 GO:0006566 threonine metabolic process The chemical reactions and pathways involving threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01021391001 4846736 4851534 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GSVIVG01003081001 8464857 8476561 GSVIVG01031546001 17278093 17292926 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031546001 17278093 17292926 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031546001 17278093 17292926 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031546001 17278093 17292926 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031546001 17278093 17292926 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01031546001 17278093 17292926 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01025179001 3652308 3658316 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008896001 3222098 3232606 GSVIVG01021310001 3839513 3839868 GSVIVG01029545001 21779346 21788145 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01029545001 21779346 21788145 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029545001 21779346 21788145 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01020058001 10987353 10989206 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01022985001 17313545 17314339 GSVIVG01037950001 11468599 11472702 GSVIVG01026573001 21551878 21558551 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01026573001 21551878 21558551 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01026573001 21551878 21558551 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01026573001 21551878 21558551 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030527001 6488135 6491153 GSVIVG01018608001 12323616 12324499 Stops, prevents or reduces the activity of an enzyme. IEA GO:0004857 enzyme inhibitor activity GSVIVG01018608001 12323616 12324499 Catalysis of the reaction: pectin + n H2O = n methanol + pectate. IEA GO:0030599 pectinesterase activity GSVIVG01037711001 7150539 7152429 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01037711001 7150539 7152429 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01037711001 7150539 7152429 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01030423001 5449744 5463695 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030423001 5449744 5463695 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01009539001 9163501 9165829 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01009539001 9163501 9165829 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01009539001 9163501 9165829 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01001977001 5983286 5985154 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016700001 460466 463578 Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01026638001 20843708 20847365 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01026638001 20843708 20847365 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01026638001 20843708 20847365 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01026638001 20843708 20847365 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01026638001 20843708 20847365 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01026638001 20843708 20847365 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01020016001 11539990 11542757 GSVIVG01025767001 12102067 12119404 GSVIVG01003104001 7253485 7253667 GSVIVG01035097001 1458292 1459032 GSVIVG01011370001 29031406 29058706 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01011370001 29031406 29058706 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01011370001 29031406 29058706 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01011370001 29031406 29058706 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01011370001 29031406 29058706 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01011370001 29031406 29058706 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01011370001 29031406 29058706 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01011370001 29031406 29058706 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01011370001 29031406 29058706 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01011370001 29031406 29058706 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01011370001 29031406 29058706 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011370001 29031406 29058706 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011370001 29031406 29058706 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. IEA GO:0016853 isomerase activity GSVIVG01011370001 29031406 29058706 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. IEA GO:0016853 isomerase activity GSVIVG01011370001 29031406 29058706 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01011370001 29031406 29058706 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01018749001 20226272 20236797 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01018749001 20226272 20236797 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01018749001 20226272 20236797 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01018749001 20226272 20236797 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01018749001 20226272 20236797 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01018749001 20226272 20236797 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01018749001 20226272 20236797 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01018749001 20226272 20236797 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01018749001 20226272 20236797 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01018749001 20226272 20236797 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01018749001 20226272 20236797 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01018749001 20226272 20236797 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01018749001 20226272 20236797 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01018749001 20226272 20236797 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01018749001 20226272 20236797 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01018749001 20226272 20236797 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01018749001 20226272 20236797 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01018749001 20226272 20236797 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01018749001 20226272 20236797 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01018749001 20226272 20236797 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01018749001 20226272 20236797 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01018749001 20226272 20236797 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01018749001 20226272 20236797 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01018749001 20226272 20236797 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01018749001 20226272 20236797 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01018749001 20226272 20236797 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018749001 20226272 20236797 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018749001 20226272 20236797 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018749001 20226272 20236797 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018749001 20226272 20236797 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018749001 20226272 20236797 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01018749001 20226272 20236797 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01018749001 20226272 20236797 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01018749001 20226272 20236797 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01018749001 20226272 20236797 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01018749001 20226272 20236797 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01018749001 20226272 20236797 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01018749001 20226272 20236797 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01018749001 20226272 20236797 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01018749001 20226272 20236797 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01000358001 12166243 12166828 GSVIVG01011251001 10128189 10137919 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01011251001 10128189 10137919 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011251001 10128189 10137919 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01036726001 23265199 23266600 The action of a molecule that contributes to the structural integrity of a cell wall. IEA GO:0005199 structural constituent of cell wall GSVIVG01032102001 22693987 22697215 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01032102001 22693987 22697215 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01023989001 1904172 1912587 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01023989001 1904172 1912587 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008262001 3846664 3879071 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01008262001 3846664 3879071 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01008262001 3846664 3879071 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01008262001 3846664 3879071 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01027212001 18211062 18213583 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01027212001 18211062 18213583 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01027212001 18211062 18213583 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01026099001 24591355 24594186 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01026099001 24591355 24594186 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01026099001 24591355 24594186 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026099001 24591355 24594186 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026099001 24591355 24594186 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01026099001 24591355 24594186 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01026099001 24591355 24594186 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01026099001 24591355 24594186 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01017784001 3456994 3469069 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01010042001 13787112 13799999 GSVIVG01027092001 17993511 17999579 GO:0006914 autophagy The process by which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation. IEA GSVIVG01011909001 3061306 3065537 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01015265001 2199317 2201202 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01015265001 2199317 2201202 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01038077001 17501024 17510552 GSVIVG01015086001 928669 934564 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. IEA GO:0008080 N-acetyltransferase activity GSVIVG01012309001 13284303 13285049 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of copper (Cu) ions from one side of a membrane to the other. IEA GO:0005375 copper ion transmembrane transporter activity GSVIVG01017972001 5188839 5200736 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017972001 5188839 5200736 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01015755001 16968652 16983804 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01015755001 16968652 16983804 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01018977001 18166917 18171198 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01018977001 18166917 18171198 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01018977001 18166917 18171198 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01018977001 18166917 18171198 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01019190001 3808171 3809034 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01019190001 3808171 3809034 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01029922001 1508014 1531663 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01029922001 1508014 1531663 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01029922001 1508014 1531663 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01029922001 1508014 1531663 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01003672001 11979231 11994159 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other. IEA GO:0005337 nucleoside transmembrane transporter activity GSVIVG01020878001 17883819 17885733 GSVIVG01003331001 9116265 9124188 GSVIVG01007275001 31204960 31207404 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01007275001 31204960 31207404 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01007275001 31204960 31207404 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01007275001 31204960 31207404 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01007275001 31204960 31207404 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01007275001 31204960 31207404 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01007275001 31204960 31207404 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01007275001 31204960 31207404 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01007275001 31204960 31207404 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01007275001 31204960 31207404 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01015572001 5087034 5092982 GO:0006487 protein amino acid N-linked glycosylation A protein amino acid glycosylation process in which a sugar unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-mannosyl-R = UDP + 4-(N-acetyl-beta-D-glucosaminyl)-beta-D-mannosyl-R. IEA GO:0003830 beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity GSVIVG01033201001 9493851 9572196 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA GSVIVG01021335001 4191623 4193472 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01021335001 4191623 4193472 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01012138001 1115322 1118841 GSVIVG01002987001 37504300 37506384 GSVIVG01016776001 1238650 1247576 GO:0009059 macromolecule biosynthetic process The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01016776001 1238650 1247576 GO:0009059 macromolecule biosynthetic process The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. IEA Catalysis of the reaction: CoA + substrate-serine = adenosine 3',5'-bisphosphate + substrate-serine-4'-phosphopantetheine. The transfer of the 4'-phosphopantetheine (Ppant) co-factor from coenzyme A to the hydroxyl side chain of the serine residue of acyl- or peptidyl-carrier protein (ACP or PCP) to convert them from the apo to the holo form. IEA GO:0008897 holo-[acyl-carrier-protein] synthase activity GSVIVG01014111001 494247 496540 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014111001 494247 496540 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014111001 494247 496540 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016581001 2641969 2645100 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01016581001 2641969 2645100 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01015225001 1955310 1959529 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the reaction: (R)-3-hydroxytetradecanoyl-[acyl-carrier protein] + UDP-N-acetylglucosamine = [acyl-carrier protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine. IEA GO:0008780 acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity GSVIVG01015225001 1955310 1959529 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01035490001 1717151 1721854 GSVIVG01002809001 36642537 36643864 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009654 oxygen evolving complex A complex, composed of a cluster of manganese, calcium and chloride ions bound to extrinsic proteins, that catalyzes the splitting of water to O2 and 4 H+. In cyanobacteria there are five extrinsic proteins in OEC (PsbO, PsbP-like, PsbQ-like, PsbU and PsbV), while in plants there are only three (PsbO, PsbP and PsbQ). IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01002809001 36642537 36643864 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0019898 extrinsic to membrane Loosely bound to one surface of a membrane, but not integrated into the hydrophobic region. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01009636001 10082485 10096930 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01009636001 10082485 10096930 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01034263001 13667359 13669356 GSVIVG01007798001 8909528 8910724 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01007798001 8909528 8910724 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01017099001 4146233 4149268 GSVIVG01018124001 6756407 6766369 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008237 metallopeptidase activity GSVIVG01018124001 6756407 6766369 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008237 metallopeptidase activity GSVIVG01018124001 6756407 6766369 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01018124001 6756407 6766369 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01018124001 6756407 6766369 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amidine, a compound of the form R-C(=NH)-NH2. IEA GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines GSVIVG01018124001 6756407 6766369 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amidine, a compound of the form R-C(=NH)-NH2. IEA GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines GSVIVG01018124001 6756407 6766369 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01018124001 6756407 6766369 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01014547001 5032636 5035368 GSVIVG01018380001 10039711 10048151 Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01018380001 10039711 10048151 Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01028296001 5849249 5860857 GO:0006471 protein amino acid ADP-ribosylation The transfer, from NAD, of ADP-ribose to protein amino acids. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01028296001 5849249 5860857 GO:0006471 protein amino acid ADP-ribosylation The transfer, from NAD, of ADP-ribose to protein amino acids. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01028296001 5849249 5860857 GO:0006471 protein amino acid ADP-ribosylation The transfer, from NAD, of ADP-ribose to protein amino acids. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01028296001 5849249 5860857 GO:0006471 protein amino acid ADP-ribosylation The transfer, from NAD, of ADP-ribose to protein amino acids. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01028296001 5849249 5860857 GO:0006471 protein amino acid ADP-ribosylation The transfer, from NAD, of ADP-ribose to protein amino acids. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor. IEA GO:0003950 NAD+ ADP-ribosyltransferase activity GSVIVG01028296001 5849249 5860857 GO:0006471 protein amino acid ADP-ribosylation The transfer, from NAD, of ADP-ribose to protein amino acids. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor. IEA GO:0003950 NAD+ ADP-ribosyltransferase activity GSVIVG01028296001 5849249 5860857 GO:0006471 protein amino acid ADP-ribosylation The transfer, from NAD, of ADP-ribose to protein amino acids. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01028296001 5849249 5860857 GO:0006471 protein amino acid ADP-ribosylation The transfer, from NAD, of ADP-ribose to protein amino acids. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01028296001 5849249 5860857 GO:0006471 protein amino acid ADP-ribosylation The transfer, from NAD, of ADP-ribose to protein amino acids. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01028296001 5849249 5860857 GO:0006471 protein amino acid ADP-ribosylation The transfer, from NAD, of ADP-ribose to protein amino acids. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01011220001 9742888 9745346 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01011220001 9742888 9745346 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01034833001 22386904 22392771 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01034833001 22386904 22392771 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025104001 4441048 4446940 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: 2 H2O2 = O2 + 2 H2O. IEA GO:0004096 catalase activity GSVIVG01025104001 4441048 4446940 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2 H2O2 = O2 + 2 H2O. IEA GO:0004096 catalase activity GSVIVG01025104001 4441048 4446940 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01025104001 4441048 4446940 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01025104001 4441048 4446940 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01025104001 4441048 4446940 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01025104001 4441048 4446940 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025104001 4441048 4446940 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025104001 4441048 4446940 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01025104001 4441048 4446940 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01025104001 4441048 4446940 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01025104001 4441048 4446940 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01008819001 2438214 2441650 GSVIVG01034072001 15397624 15399438 GSVIVG01026222001 14351963 14353644 GSVIVG01011339001 8903435 8910039 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01021637001 8511744 8514387 GSVIVG01034581001 19092794 19099983 GSVIVG01021025001 15127347 15128808 GSVIVG01030079001 9637934 9652142 GO:0006006 glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030079001 9637934 9652142 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030079001 9637934 9652142 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030079001 9637934 9652142 GO:0006006 glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. IEA Catalysis of the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+. IEA GO:0004345 glucose-6-phosphate dehydrogenase activity GSVIVG01030079001 9637934 9652142 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+. IEA GO:0004345 glucose-6-phosphate dehydrogenase activity GSVIVG01030079001 9637934 9652142 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+. IEA GO:0004345 glucose-6-phosphate dehydrogenase activity GSVIVG01030079001 9637934 9652142 GO:0006006 glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01030079001 9637934 9652142 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01030079001 9637934 9652142 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01030079001 9637934 9652142 GO:0006006 glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01030079001 9637934 9652142 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01030079001 9637934 9652142 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01001523001 976247 994669 GSVIVG01027342001 16255995 16276812 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031451001 18359043 18369317 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031451001 18359043 18369317 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. IEA GO:0008080 N-acetyltransferase activity GSVIVG01031451001 18359043 18369317 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01033148001 8461866 8466086 GSVIVG01023377001 19194493 19194964 GO:0006306 DNA methylation The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01026906001 19518113 19518868 GSVIVG01029789001 14705479 14706883 GO:0009765 photosynthesis, light harvesting Absorption and transfer of the energy absorbed from light photons between photosystem reaction centers. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01026018001 25820370 25821085 GSVIVG01006401001 25635972 25648695 GSVIVG01003247001 8292296 8292588 GSVIVG01035495001 1786448 1789567 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA GSVIVG01009328001 7474794 7480633 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01009328001 7474794 7480633 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01035814001 4575192 4576673 GSVIVG01023144001 22025601 22029453 GSVIVG01016046001 17853039 17879949 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016046001 17853039 17879949 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. IEA GO:0004722 protein serine/threonine phosphatase activity GSVIVG01028196001 4540190 4544180 GSVIVG01009026001 4377596 4385665 GSVIVG01017837001 3916717 3917496 GO:0006278 RNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01017837001 3916717 3917496 GO:0006278 RNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. IEA Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time. IEA GO:0003964 RNA-directed DNA polymerase activity GSVIVG01037802001 7771297 7774507 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01022227001 17680479 17683544 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031422001 18786636 18787503 GSVIVG01011380001 29184240 29185221 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01014155001 905894 909343 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014155001 905894 909343 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014155001 905894 909343 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014155001 905894 909343 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026473001 22994815 22997726 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01026473001 22994815 22997726 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01004317001 38061395 38064311 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01024372001 1716748 1717044 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GSVIVG01024372001 1716748 1717044 GO:0009607 response to biotic stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism. IEA GSVIVG01010776001 22475808 22477334 GSVIVG01015722001 16377478 16379930 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01015722001 16377478 16379930 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01015722001 16377478 16379930 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01015722001 16377478 16379930 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01015722001 16377478 16379930 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01015722001 16377478 16379930 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01015722001 16377478 16379930 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01015722001 16377478 16379930 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01015722001 16377478 16379930 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01015722001 16377478 16379930 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01015722001 16377478 16379930 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01015722001 16377478 16379930 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01015722001 16377478 16379930 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01015722001 16377478 16379930 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01015722001 16377478 16379930 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01015722001 16377478 16379930 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01015722001 16377478 16379930 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01015722001 16377478 16379930 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01015722001 16377478 16379930 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01015722001 16377478 16379930 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01000232001 20167394 20169125 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01028433001 7475679 7489174 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01028433001 7475679 7489174 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01028433001 7475679 7489174 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01028433001 7475679 7489174 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01028433001 7475679 7489174 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029906001 1283264 1294294 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029906001 1283264 1294294 GO:0006535 cysteine biosynthetic process from serine The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029906001 1283264 1294294 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029906001 1283264 1294294 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029906001 1283264 1294294 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the reaction: O3-acetyl-L-serine + H2S = L-cysteine + acetate. IEA GO:0004124 cysteine synthase activity GSVIVG01029906001 1283264 1294294 GO:0006535 cysteine biosynthetic process from serine The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine. IEA Catalysis of the reaction: O3-acetyl-L-serine + H2S = L-cysteine + acetate. IEA GO:0004124 cysteine synthase activity GSVIVG01029906001 1283264 1294294 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: O3-acetyl-L-serine + H2S = L-cysteine + acetate. IEA GO:0004124 cysteine synthase activity GSVIVG01029906001 1283264 1294294 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: O3-acetyl-L-serine + H2S = L-cysteine + acetate. IEA GO:0004124 cysteine synthase activity GSVIVG01029906001 1283264 1294294 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01029906001 1283264 1294294 GO:0006535 cysteine biosynthetic process from serine The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01029906001 1283264 1294294 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01029906001 1283264 1294294 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01029906001 1283264 1294294 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01029906001 1283264 1294294 GO:0006535 cysteine biosynthetic process from serine The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01029906001 1283264 1294294 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01029906001 1283264 1294294 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01006249001 24067295 24068266 GSVIVG01003124001 7481806 7484658 GSVIVG01008757001 1729783 1732607 GSVIVG01006641001 27213484 27236317 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01006641001 27213484 27236317 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01006641001 27213484 27236317 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01006641001 27213484 27236317 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01006641001 27213484 27236317 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01006641001 27213484 27236317 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01006641001 27213484 27236317 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006641001 27213484 27236317 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006641001 27213484 27236317 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006641001 27213484 27236317 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01006641001 27213484 27236317 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01006641001 27213484 27236317 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01022907001 18150697 18151192 GSVIVG01015985001 16806395 16810270 GSVIVG01037558001 11443683 11452734 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01037558001 11443683 11452734 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01037558001 11443683 11452734 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01037558001 11443683 11452734 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026062001 25091932 25094565 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01004732001 15627739 15635816 GSVIVG01032359001 26668723 26686579 GSVIVG01019636001 2121952 2123065 Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01019636001 2121952 2123065 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01024710001 7567081 7569864 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01024710001 7567081 7569864 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024710001 7567081 7569864 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity. IEA GO:0004721 phosphoprotein phosphatase activity GSVIVG01024710001 7567081 7569864 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. IEA GO:0004722 protein serine/threonine phosphatase activity GSVIVG01024710001 7567081 7569864 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01024710001 7567081 7569864 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01003028001 37573044 37575812 GSVIVG01004470001 38718274 38719774 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01036288001 3398694 3404754 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01036288001 3398694 3404754 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01036288001 3398694 3404754 GO:0006427 histidyl-tRNA aminoacylation The process of coupling histidine to histidyl-tRNA, catalyzed by histidyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01036288001 3398694 3404754 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01036288001 3398694 3404754 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01036288001 3398694 3404754 GO:0006427 histidyl-tRNA aminoacylation The process of coupling histidine to histidyl-tRNA, catalyzed by histidyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01036288001 3398694 3404754 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His). IEA GO:0004821 histidine-tRNA ligase activity GSVIVG01036288001 3398694 3404754 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His). IEA GO:0004821 histidine-tRNA ligase activity GSVIVG01036288001 3398694 3404754 GO:0006427 histidyl-tRNA aminoacylation The process of coupling histidine to histidyl-tRNA, catalyzed by histidyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His). IEA GO:0004821 histidine-tRNA ligase activity GSVIVG01036288001 3398694 3404754 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036288001 3398694 3404754 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036288001 3398694 3404754 GO:0006427 histidyl-tRNA aminoacylation The process of coupling histidine to histidyl-tRNA, catalyzed by histidyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017116001 4304363 4309016 GSVIVG01001106001 22671239 22673946 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01020217001 8939369 8950208 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of potassium ions (K+) from one side of a membrane to the other. IEA GO:0015079 potassium ion transmembrane transporter activity GSVIVG01038143001 23820102 23824960 GSVIVG01024743001 7284289 7297469 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01024743001 7284289 7297469 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024743001 7284289 7297469 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01024743001 7284289 7297469 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01024743001 7284289 7297469 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01031313001 449664 452490 GO:0006730 one-carbon metabolic process The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. IEA Catalysis of the reaction: ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine. IEA GO:0004478 methionine adenosyltransferase activity GSVIVG01031313001 449664 452490 GO:0006730 one-carbon metabolic process The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006040001 23400901 23402723 GSVIVG01021489001 6066284 6066971 GSVIVG01024541001 9016608 9018011 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025569001 13986884 13988371 GSVIVG01011499001 30053529 30054473 GSVIVG01036591001 18763103 18764382 GSVIVG01034399001 16835617 16836654 GSVIVG01011869001 3407115 3417751 GSVIVG01015186001 1637266 1641248 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01015186001 1637266 1641248 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01023503001 10846879 10850485 GSVIVG01019459001 814055 819061 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01019459001 814055 819061 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01000800001 258493 265276 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01033975001 16163551 16181986 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01033975001 16163551 16181986 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with double-stranded RNA. IEA GO:0003725 double-stranded RNA binding GSVIVG01031261001 708653 713525 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01037377001 14757029 14762137 GSVIVG01026196001 13872806 13876220 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01026196001 13872806 13876220 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01026196001 13872806 13876220 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01026196001 13872806 13876220 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01026196001 13872806 13876220 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035163001 12456224 12458547 GSVIVG01012335001 377951 378906 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01012335001 377951 378906 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01038598001 21607168 21608207 GSVIVG01013855001 5349767 5350366 GSVIVG01037379001 14742789 14747843 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01037379001 14742789 14747843 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01030184001 10739627 10740729 GSVIVG01036567001 23552675 23569797 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01036567001 23552675 23569797 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01036567001 23552675 23569797 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01036567001 23552675 23569797 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01036567001 23552675 23569797 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01036567001 23552675 23569797 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01036567001 23552675 23569797 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01036567001 23552675 23569797 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01018904001 18771262 18772949 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01017101001 4162767 4167993 GSVIVG01030161001 11433649 11434784 GSVIVG01024771001 7093095 7105060 GO:0006414 translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01024771001 7093095 7105060 GO:0006414 translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01035383001 914901 915869 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01035383001 914901 915869 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01035383001 914901 915869 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01035383001 914901 915869 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01010100001 15386735 15409114 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01007856001 8313492 8334526 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion. IEA GO:0004806 triglyceride lipase activity GSVIVG01005244001 19813066 19814135 GSVIVG01013270001 5826770 5900307 GO:0008104 protein localization Any process by which a protein is transported to, or maintained in, a specific location. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01032487001 27812667 27819608 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01032487001 27812667 27819608 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01032487001 27812667 27819608 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01032487001 27812667 27819608 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015984001 16793442 16796455 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01015984001 16793442 16796455 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01034043001 15623502 15630796 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01034043001 15623502 15630796 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01034043001 15623502 15630796 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01034043001 15623502 15630796 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01034043001 15623502 15630796 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01002253001 33709111 33717273 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01002253001 33709111 33717273 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01002253001 33709111 33717273 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01002253001 33709111 33717273 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01002253001 33709111 33717273 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01002253001 33709111 33717273 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01002253001 33709111 33717273 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01002253001 33709111 33717273 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01002253001 33709111 33717273 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01002253001 33709111 33717273 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035595001 2596951 2601892 GSVIVG01024581001 8654548 8656687 GSVIVG01028700001 19678032 19685549 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028700001 19678032 19685549 Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01014208001 1480082 1486910 GO:0006506 GPI anchor biosynthetic process The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol moiety is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate moiety, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage. IEA GO:0031227 intrinsic to endoplasmic reticulum membrane Located in the endoplasmic reticulum membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01020581001 4074994 4078107 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01022496001 3917600 3921496 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA GSVIVG01032946001 24508993 24524474 GO:0016246 RNA interference The process by which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes. IEA GO:0016442 RNA-induced silencing complex A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01032946001 24508993 24524474 GO:0016246 RNA interference The process by which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes. IEA GO:0016442 RNA-induced silencing complex A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032946001 24508993 24524474 GO:0016246 RNA interference The process by which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes. IEA GO:0016442 RNA-induced silencing complex A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01028014001 3200984 3204735 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028014001 3200984 3204735 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028014001 3200984 3204735 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028014001 3200984 3204735 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028014001 3200984 3204735 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028014001 3200984 3204735 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028014001 3200984 3204735 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. IEA GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GSVIVG01028014001 3200984 3204735 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. IEA GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GSVIVG01028014001 3200984 3204735 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. IEA GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GSVIVG01028014001 3200984 3204735 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01028014001 3200984 3204735 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01028014001 3200984 3204735 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01016732001 725363 732663 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion. IEA GO:0004091 carboxylesterase activity GSVIVG01016732001 725363 732663 GO:0016042 lipid catabolic process The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion. IEA GO:0004091 carboxylesterase activity GSVIVG01016732001 725363 732663 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion. IEA GO:0004806 triglyceride lipase activity GSVIVG01016732001 725363 732663 GO:0016042 lipid catabolic process The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion. IEA GO:0004806 triglyceride lipase activity GSVIVG01006078001 41170621 41172884 GSVIVG01000536001 7288888 7289789 GSVIVG01009486001 8769250 8769811 GSVIVG01028160001 4304534 4306945 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA GSVIVG01028160001 4304534 4306945 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GSVIVG01015325001 2709081 2712592 GSVIVG01012490001 13829611 13833472 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01037179001 28282937 28284029 GSVIVG01028441001 7576177 7591614 GO:0006519 cellular amino acid and derivative metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028441001 7576177 7591614 GO:0019752 carboxylic acid metabolic process The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028441001 7576177 7591614 GO:0006519 cellular amino acid and derivative metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells. IEA Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. IEA GO:0016831 carboxy-lyase activity GSVIVG01028441001 7576177 7591614 GO:0019752 carboxylic acid metabolic process The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). IEA Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. IEA GO:0016831 carboxy-lyase activity GSVIVG01028441001 7576177 7591614 GO:0006519 cellular amino acid and derivative metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01028441001 7576177 7591614 GO:0019752 carboxylic acid metabolic process The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01037842001 7244888 7245118 GSVIVG01012932001 13766755 13773042 Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides. IEA GO:0004866 endopeptidase inhibitor activity GSVIVG01019952001 12441952 12443272 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01021300001 3690372 3693820 GO:0016070 RNA metabolic process The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021300001 3690372 3693820 GO:0016070 RNA metabolic process The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: a nucleoside cyclic phosphate + H2O = a nucleoside phosphate. IEA GO:0004112 cyclic-nucleotide phosphodiesterase activity GSVIVG01000004001 2638641 2642144 GSVIVG01004951001 16964982 16981301 GSVIVG01012015001 2171001 2171522 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012015001 2171001 2171522 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01034899001 16231736 16233196 GSVIVG01029959001 2311465 2340885 GSVIVG01016689001 378369 380107 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of a lipid or phospholipid. IEA GO:0016298 lipase activity GSVIVG01016689001 378369 380107 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01003339001 9165121 9165561 GSVIVG01018993001 18005185 18008781 GO:0006397 mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01018993001 18005185 18008781 GO:0006397 mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01018993001 18005185 18008781 GO:0006397 mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01008501001 1307825 1308955 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008501001 1307825 1308955 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01008501001 1307825 1308955 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01004399001 38377996 38382508 Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage. IEA GO:0016209 antioxidant activity GSVIVG01004399001 38377996 38382508 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01002030001 32391546 32400290 GSVIVG01017241001 5825471 5831501 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01029261001 17885453 17886206 GSVIVG01011939001 2806808 2878486 GSVIVG01018214001 13159995 13160969 GSVIVG01031358001 54203 55122 GSVIVG01037052001 8343093 8347919 GO:0009060 aerobic respiration The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01037052001 8343093 8347919 GO:0009060 aerobic respiration The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01037052001 8343093 8347919 GO:0009060 aerobic respiration The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01015579001 5145518 5170011 GO:0032313 regulation of Rab GTPase activity Any process that modulates the activity of a GTPase of the Rab family. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Increases the rate of GTP hydrolysis by a GTPase of the Rab family. IEA GO:0005097 Rab GTPase activator activity GSVIVG01025289001 2413854 2414194 GSVIVG01038350001 13377683 13393282 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01038350001 13377683 13393282 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01012236001 312339 317465 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: 6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate. IEA GO:0017057 6-phosphogluconolactonase activity GSVIVG01012236001 312339 317465 GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. IEA Catalysis of the reaction: 6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate. IEA GO:0017057 6-phosphogluconolactonase activity GSVIVG01030076001 9624257 9627071 GSVIVG01025055001 4916001 4919401 GSVIVG01016849001 1940557 1947535 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016849001 1940557 1947535 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01016849001 1940557 1947535 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01016849001 1940557 1947535 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01036427001 5033588 5035681 GSVIVG01002748001 36313494 36315146 GSVIVG01012103001 1426626 1460682 GSVIVG01024857001 6420422 6423513 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01024857001 6420422 6423513 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01024857001 6420422 6423513 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01024857001 6420422 6423513 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01036485001 22586260 22598834 GO:0032313 regulation of Rab GTPase activity Any process that modulates the activity of a GTPase of the Rab family. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Increases the rate of GTP hydrolysis by a GTPase of the Rab family. IEA GO:0005097 Rab GTPase activator activity GSVIVG01031680001 20109283 20118389 GSVIVG01020282001 21916038 21918539 GSVIVG01013416001 601322 605100 GSVIVG01028312001 6019702 6023214 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01028312001 6019702 6023214 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01013238001 6404368 6406247 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01013238001 6404368 6406247 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01013238001 6404368 6406247 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01013238001 6404368 6406247 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01013238001 6404368 6406247 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01013238001 6404368 6406247 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01013238001 6404368 6406247 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01013238001 6404368 6406247 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01013238001 6404368 6406247 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01013238001 6404368 6406247 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01033892001 16959496 16964034 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). IEA GO:0003755 peptidyl-prolyl cis-trans isomerase activity GSVIVG01002863001 36892781 36898338 GSVIVG01024142001 835200 844911 GSVIVG01029452001 22704313 22716069 The action of a molecule that contributes to the structural integrity of a cytoskeletal structure. IEA GO:0005200 structural constituent of cytoskeleton GSVIVG01014756001 9307511 9308113 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01024067001 1393093 1396092 Catalysis of the transfer of the amide nitrogen of glutamine to a variety of substrates. GATases catalyze two separate reactions at two active sites, which are located either on a single polypeptide chain or on different subunits. In the glutaminase reaction, glutamine is hydrolyzed to glutamate and ammonia, which is added to an acceptor substrate in the synthase reaction. IEA GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor GSVIVG01012185001 715659 718644 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01029490001 22304110 22305692 GSVIVG01032699001 1423093 1429301 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032699001 1423093 1429301 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032699001 1423093 1429301 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01032699001 1423093 1429301 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01030442001 5587662 5588747 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha1-adrenergic receptors; the activity involves transmitting the signal to the Gq alpha subunit of a heterotrimeric G protein. IEA GO:0004937 alpha1-adrenergic receptor activity GSVIVG01030442001 5587662 5588747 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha1-adrenergic receptors; the activity involves transmitting the signal to the Gq alpha subunit of a heterotrimeric G protein. IEA GO:0004937 alpha1-adrenergic receptor activity GSVIVG01030442001 5587662 5588747 GO:0051260 protein homooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha1-adrenergic receptors; the activity involves transmitting the signal to the Gq alpha subunit of a heterotrimeric G protein. IEA GO:0004937 alpha1-adrenergic receptor activity GSVIVG01030442001 5587662 5588747 GO:0051260 protein homooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha1-adrenergic receptors; the activity involves transmitting the signal to the Gq alpha subunit of a heterotrimeric G protein. IEA GO:0004937 alpha1-adrenergic receptor activity GSVIVG01033244001 22231608 22234293 GSVIVG01026846001 19993952 20009808 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026846001 19993952 20009808 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026846001 19993952 20009808 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026846001 19993952 20009808 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026846001 19993952 20009808 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026846001 19993952 20009808 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026846001 19993952 20009808 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026846001 19993952 20009808 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026846001 19993952 20009808 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01026846001 19993952 20009808 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01026846001 19993952 20009808 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01026846001 19993952 20009808 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01026846001 19993952 20009808 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01026846001 19993952 20009808 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01026846001 19993952 20009808 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01026846001 19993952 20009808 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01022261001 17969593 17973374 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01022261001 17969593 17973374 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01022261001 17969593 17973374 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01022261001 17969593 17973374 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01022261001 17969593 17973374 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025425001 885701 894052 GSVIVG01000692001 15663551 15663916 GSVIVG01020601001 3919806 3931766 GSVIVG01027121001 17648456 17651409 GSVIVG01037080001 7987351 7989378 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01037080001 7987351 7989378 Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01026554001 21924474 21924838 GSVIVG01032594001 28664569 28678844 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0019028 viral capsid The protein coat that surrounds the infective nucleic acid in some virus particles. It comprises numerous regularly arranged subunits, or capsomeres. IEA Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin. IEA GO:0004221 ubiquitin thiolesterase activity GSVIVG01032594001 28664569 28678844 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0019028 viral capsid The protein coat that surrounds the infective nucleic acid in some virus particles. It comprises numerous regularly arranged subunits, or capsomeres. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01016998001 3318607 3327354 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016998001 3318607 3327354 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016998001 3318607 3327354 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01016998001 3318607 3327354 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01035078001 1312475 1313977 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01035078001 1312475 1313977 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01011948001 2726715 2743674 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023465001 11434185 11439282 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GSVIVG01038690001 20956387 20986185 GSVIVG01028355001 6512601 6518722 GSVIVG01010832001 23190812 23192169 GSVIVG01007914001 7609546 7613137 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01029800001 14993139 15010800 GO:0007205 activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway The initiation of the activity of the inactive enzyme protein kinase C as the result of a series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol 3-phosphate. IEA GO:0004143 diacylglycerol kinase activity GSVIVG01025226001 3038461 3048042 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01015132001 1292087 1292749 GSVIVG01016378001 4361864 4362730 GSVIVG01010522001 21412776 21417820 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01011365001 28987294 28991063 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01011365001 28987294 28991063 GO:0019318 hexose metabolic process The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01011365001 28987294 28991063 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. IEA GO:0016853 isomerase activity GSVIVG01011365001 28987294 28991063 GO:0019318 hexose metabolic process The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule. IEA Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. IEA GO:0016853 isomerase activity GSVIVG01011365001 28987294 28991063 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01011365001 28987294 28991063 GO:0019318 hexose metabolic process The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule. IEA Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01025254001 2674348 2674882 GSVIVG01031079001 2561519 2562552 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with manganese (Mn) ions. IEA GO:0030145 manganese ion binding GSVIVG01031079001 2561519 2562552 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Functions in the storage of nutritious substrates. IEA GO:0045735 nutrient reservoir activity GSVIVG01031079001 2561519 2562552 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01011459001 29786095 29790011 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the reaction: pectin + n H2O = n methanol + pectate. IEA GO:0030599 pectinesterase activity GSVIVG01011690001 5102907 5104090 GSVIVG01020897001 17616325 17619434 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01020897001 17616325 17619434 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01020897001 17616325 17619434 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01020897001 17616325 17619434 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020897001 17616325 17619434 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000609001 6571809 6583497 GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor. IEA GO:0003954 NADH dehydrogenase activity GSVIVG01000609001 6571809 6583497 GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. IEA GO:0008137 NADH dehydrogenase (ubiquinone) activity GSVIVG01035924001 5937871 5970124 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035924001 5937871 5970124 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01025792001 11796497 11798560 GSVIVG01008444001 1993493 2012416 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01007067001 29985909 29988648 GSVIVG01000343001 11784904 11785720 GSVIVG01027921001 9458704 9461802 The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01018164001 13710962 13712124 GSVIVG01018966001 18275834 18276875 GSVIVG01009843001 11734395 11741869 GSVIVG01034599001 14701256 14707290 GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01034599001 14701256 14707290 GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate. IEA GO:0008253 5'-nucleotidase activity GSVIVG01037427001 13941592 13951660 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01037427001 13941592 13951660 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01037427001 13941592 13951660 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01037427001 13941592 13951660 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01037427001 13941592 13951660 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01037427001 13941592 13951660 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01037427001 13941592 13951660 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01037427001 13941592 13951660 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01037427001 13941592 13951660 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037427001 13941592 13951660 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037427001 13941592 13951660 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01037427001 13941592 13951660 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01037427001 13941592 13951660 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01037427001 13941592 13951660 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01009645001 10155356 10159457 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01032560001 28370966 28373424 GSVIVG01031323001 371097 371605 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the reaction: pectin + n H2O = n methanol + pectate. IEA GO:0030599 pectinesterase activity GSVIVG01001197001 890679 905893 GSVIVG01000506001 15177026 15182340 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01000506001 15177026 15182340 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01000506001 15177026 15182340 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01000506001 15177026 15182340 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01009960001 12841218 12848327 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of a lipid or phospholipid. IEA GO:0016298 lipase activity GSVIVG01009960001 12841218 12848327 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01033316001 21572153 21574979 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01033316001 21572153 21574979 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01028734001 19277664 19288859 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01028734001 19277664 19288859 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01028734001 19277664 19288859 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01028734001 19277664 19288859 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01028734001 19277664 19288859 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028734001 19277664 19288859 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028734001 19277664 19288859 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028734001 19277664 19288859 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01000979001 11080390 11081196 GSVIVG01008486001 1436683 1438596 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01009105001 5077428 5081480 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01009105001 5077428 5081480 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01009105001 5077428 5081480 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01009105001 5077428 5081480 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01033273001 21956911 21961543 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01033273001 21956911 21961543 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01033273001 21956911 21961543 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01033273001 21956911 21961543 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01033273001 21956911 21961543 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01033273001 21956911 21961543 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01010314001 19335593 19336894 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01023731001 10239246 10240756 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01036625001 19315951 19316880 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01036625001 19315951 19316880 Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01016816001 1638178 1641769 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016816001 1638178 1641769 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. IEA GO:0004722 protein serine/threonine phosphatase activity GSVIVG01025819001 11511620 11521500 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025819001 11511620 11521500 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025430001 862165 870023 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030189001 10709884 10714240 GSVIVG01023627001 8204047 8208734 GSVIVG01029375001 15684397 15698230 GSVIVG01013730001 8106260 8107501 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01000234001 20243491 20280140 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000234001 20243491 20280140 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000234001 20243491 20280140 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000234001 20243491 20280140 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000234001 20243491 20280140 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000234001 20243491 20280140 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000234001 20243491 20280140 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000234001 20243491 20280140 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000234001 20243491 20280140 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000234001 20243491 20280140 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000234001 20243491 20280140 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000234001 20243491 20280140 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000234001 20243491 20280140 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01000234001 20243491 20280140 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01000234001 20243491 20280140 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01000234001 20243491 20280140 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01000234001 20243491 20280140 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01000234001 20243491 20280140 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01000234001 20243491 20280140 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01000234001 20243491 20280140 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01000234001 20243491 20280140 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01000234001 20243491 20280140 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01000234001 20243491 20280140 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01000234001 20243491 20280140 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01000234001 20243491 20280140 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01000234001 20243491 20280140 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01000234001 20243491 20280140 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01000234001 20243491 20280140 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01000234001 20243491 20280140 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01000234001 20243491 20280140 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01000234001 20243491 20280140 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01000234001 20243491 20280140 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01000234001 20243491 20280140 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01000234001 20243491 20280140 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01000234001 20243491 20280140 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01000234001 20243491 20280140 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01012183001 726650 729085 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. IEA GO:0004969 histamine receptor activity GSVIVG01012329001 185134 188740 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01012329001 185134 188740 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01012329001 185134 188740 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01012329001 185134 188740 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01012329001 185134 188740 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01012329001 185134 188740 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01009364001 7788780 7796734 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01021319001 3976426 3990034 GSVIVG01011415001 29501228 29503239 GSVIVG01026096001 24609787 24626801 GSVIVG01011320001 8452420 8458092 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01011320001 8452420 8458092 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01011320001 8452420 8458092 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01011320001 8452420 8458092 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01011320001 8452420 8458092 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01011320001 8452420 8458092 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01011320001 8452420 8458092 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01011320001 8452420 8458092 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01011320001 8452420 8458092 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01011320001 8452420 8458092 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01011320001 8452420 8458092 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01011320001 8452420 8458092 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01011320001 8452420 8458092 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01011320001 8452420 8458092 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01011320001 8452420 8458092 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01011320001 8452420 8458092 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01011320001 8452420 8458092 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01011320001 8452420 8458092 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01011320001 8452420 8458092 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01011320001 8452420 8458092 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01011320001 8452420 8458092 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01011320001 8452420 8458092 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01011320001 8452420 8458092 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01011320001 8452420 8458092 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01011320001 8452420 8458092 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01011320001 8452420 8458092 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01011320001 8452420 8458092 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01011320001 8452420 8458092 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01011320001 8452420 8458092 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01011320001 8452420 8458092 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01025165001 3826347 3829954 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01029223001 18367343 18369892 GSVIVG01021904001 5801270 5814340 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01021904001 5801270 5814340 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with double-stranded RNA. IEA GO:0003725 double-stranded RNA binding GSVIVG01013935001 7044817 7045876 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01013935001 7044817 7045876 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01028638001 11411106 11440698 GSVIVG01009372001 7855776 7862786 GSVIVG01026304001 13197213 13217334 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026304001 13197213 13217334 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008576001 756550 757963 GSVIVG01014948001 12661108 12663417 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01014948001 12661108 12663417 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01014948001 12661108 12663417 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01014948001 12661108 12663417 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01011097001 1617651 1628903 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01003927001 13861105 13862633 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01003927001 13861105 13862633 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01022181001 17247589 17250725 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01022181001 17247589 17250725 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of the reaction: 2 L-ascorbate + O2 = 2 dehydroascorbate + 2 H2O. IEA GO:0008447 L-ascorbate oxidase activity GSVIVG01022181001 17247589 17250725 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01034319001 14814178 14816329 GSVIVG01026406001 15699277 15713817 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01026406001 15699277 15713817 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01026406001 15699277 15713817 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01026406001 15699277 15713817 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009254001 6693573 6703325 GO:0015770 sucrose transport The directed movement of sucrose into, out of, within or between cells by means of some external agent such as a transporter or pore. Sucrose is the disaccharide fructofuranosyl-glucopyranoside. IEA GO:0005887 integral to plasma membrane Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Catalysis of the transfer of sucrose from one side of the membrane to the other. Sucrose is the disaccharide O-beta-D-fructofuranosyl-(2->1)-alpha-D-glucopyranoside, a sweet-tasting, non-reducing sugar isolated industrially from sugar beet or sugar cane. IEA GO:0008515 sucrose transmembrane transporter activity GSVIVG01009254001 6693573 6703325 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005887 integral to plasma membrane Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Catalysis of the transfer of sucrose from one side of the membrane to the other. Sucrose is the disaccharide O-beta-D-fructofuranosyl-(2->1)-alpha-D-glucopyranoside, a sweet-tasting, non-reducing sugar isolated industrially from sugar beet or sugar cane. IEA GO:0008515 sucrose transmembrane transporter activity GSVIVG01019523001 1331283 1335833 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019523001 1331283 1335833 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01019523001 1331283 1335833 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01036478001 22555904 22557037 GSVIVG01033373001 21127130 21127333 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out); by a phosphorylative mechanism. IEA GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism GSVIVG01033373001 21127130 21127333 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out); by a phosphorylative mechanism. IEA GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism GSVIVG01033373001 21127130 21127333 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out); by a phosphorylative mechanism. IEA GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism GSVIVG01033373001 21127130 21127333 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out); by a phosphorylative mechanism. IEA GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism GSVIVG01033373001 21127130 21127333 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out); by a phosphorylative mechanism. IEA GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism GSVIVG01033373001 21127130 21127333 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out); by a phosphorylative mechanism. IEA GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism GSVIVG01033373001 21127130 21127333 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01033373001 21127130 21127333 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01033373001 21127130 21127333 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01033373001 21127130 21127333 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01033373001 21127130 21127333 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01033373001 21127130 21127333 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01033373001 21127130 21127333 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01033373001 21127130 21127333 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01033373001 21127130 21127333 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01033373001 21127130 21127333 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01033373001 21127130 21127333 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01033373001 21127130 21127333 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01011521001 13196758 13200394 GSVIVG01028374001 6777582 6780177 GSVIVG01014520001 4745383 4749486 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014520001 4745383 4749486 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014520001 4745383 4749486 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014520001 4745383 4749486 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014520001 4745383 4749486 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014520001 4745383 4749486 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014520001 4745383 4749486 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014520001 4745383 4749486 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014520001 4745383 4749486 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01014520001 4745383 4749486 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01017151001 4725048 4728006 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025362001 1470318 1508936 GO:0006075 1,3-beta-glucan biosynthetic process The chemical reactions and pathways resulting in the formation of beta-1,3 glucans, compounds composed of glucose residues linked by 1,3-beta-D-glucosidic bonds. IEA GO:0000148 1,3-beta-glucan synthase complex A protein complex that catalyzes the transfer of a glucose moiety from UDP-glucose to a 1,3-beta-D-glucan chain. IEA Catalysis of the reaction: UDP-glucose + 1,3-beta-D-glucosyl(n) = UDP + 1,3-beta-D-glucosyl(n+1). IEA GO:0003843 1,3-beta-glucan synthase activity GSVIVG01025362001 1470318 1508936 GO:0006075 1,3-beta-glucan biosynthetic process The chemical reactions and pathways resulting in the formation of beta-1,3 glucans, compounds composed of glucose residues linked by 1,3-beta-D-glucosidic bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: UDP-glucose + 1,3-beta-D-glucosyl(n) = UDP + 1,3-beta-D-glucosyl(n+1). IEA GO:0003843 1,3-beta-glucan synthase activity GSVIVG01005753001 21839218 21842546 GO:0006817 phosphate transport The directed movement of phosphate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a inorganic phosphate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0005315 inorganic phosphate transmembrane transporter activity GSVIVG01023986001 1914965 1915753 GSVIVG01037764001 7666719 7669351 GSVIVG01033873001 17099183 17102569 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01009520001 9027008 9030640 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009520001 9027008 9030640 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009520001 9027008 9030640 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009520001 9027008 9030640 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01009520001 9027008 9030640 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01009520001 9027008 9030640 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01009520001 9027008 9030640 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01009520001 9027008 9030640 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01009520001 9027008 9030640 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01012181001 731577 733548 GSVIVG01006337001 281795 296349 GSVIVG01032499001 27919404 27924017 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01032499001 27919404 27924017 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01032499001 27919404 27924017 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01032499001 27919404 27924017 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025193001 3507793 3517339 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025193001 3507793 3517339 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025193001 3507793 3517339 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01025193001 3507793 3517339 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01025193001 3507793 3517339 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01025193001 3507793 3517339 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01038788001 909339 960518 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01038788001 909339 960518 Catalysis of the transfer of the amide nitrogen of glutamine to a variety of substrates. GATases catalyze two separate reactions at two active sites, which are located either on a single polypeptide chain or on different subunits. In the glutaminase reaction, glutamine is hydrolyzed to glutamate and ammonia, which is added to an acceptor substrate in the synthase reaction. IEA GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor GSVIVG01011309001 8277291 8278472 GSVIVG01038453001 12665800 12685310 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01037540001 11805244 11819137 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01037540001 11805244 11819137 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate. IEA GO:0003774 motor activity GSVIVG01037540001 11805244 11819137 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01037540001 11805244 11819137 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003498001 10776955 10778069 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01033178001 9011204 9019599 GSVIVG01007813001 8775781 8782479 GSVIVG01013363001 949015 961356 GO:0042254 ribosome biogenesis The process of the formation of the constituents of the ribosome subunits, their assembly, and their transport to the sites of protein synthesis. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01034175001 14624537 14627264 GSVIVG01036776001 22688699 22717134 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01036776001 22688699 22717134 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01036776001 22688699 22717134 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01036776001 22688699 22717134 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01036776001 22688699 22717134 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01036776001 22688699 22717134 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01038645001 21243055 21243315 GSVIVG01033900001 16873976 16875869 GSVIVG01003206001 7887901 7905763 GSVIVG01037361001 15030481 15038447 GSVIVG01020576001 4134574 4159216 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020576001 4134574 4159216 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020576001 4134574 4159216 GO:0006436 tryptophanyl-tRNA aminoacylation The process of coupling tryptophan to tryptophanyl-tRNA, catalyzed by tryptophanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020576001 4134574 4159216 GO:0006437 tyrosyl-tRNA aminoacylation The process of coupling tyrosine to tyrosyl-tRNA, catalyzed by tyrosyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020576001 4134574 4159216 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01020576001 4134574 4159216 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01020576001 4134574 4159216 GO:0006436 tryptophanyl-tRNA aminoacylation The process of coupling tryptophan to tryptophanyl-tRNA, catalyzed by tryptophanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01020576001 4134574 4159216 GO:0006437 tyrosyl-tRNA aminoacylation The process of coupling tyrosine to tyrosyl-tRNA, catalyzed by tyrosyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01020576001 4134574 4159216 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophanyl-tRNA(Trp). IEA GO:0004830 tryptophan-tRNA ligase activity GSVIVG01020576001 4134574 4159216 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophanyl-tRNA(Trp). IEA GO:0004830 tryptophan-tRNA ligase activity GSVIVG01020576001 4134574 4159216 GO:0006436 tryptophanyl-tRNA aminoacylation The process of coupling tryptophan to tryptophanyl-tRNA, catalyzed by tryptophanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophanyl-tRNA(Trp). IEA GO:0004830 tryptophan-tRNA ligase activity GSVIVG01020576001 4134574 4159216 GO:0006437 tyrosyl-tRNA aminoacylation The process of coupling tyrosine to tyrosyl-tRNA, catalyzed by tyrosyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophanyl-tRNA(Trp). IEA GO:0004830 tryptophan-tRNA ligase activity GSVIVG01020576001 4134574 4159216 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr). IEA GO:0004831 tyrosine-tRNA ligase activity GSVIVG01020576001 4134574 4159216 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr). IEA GO:0004831 tyrosine-tRNA ligase activity GSVIVG01020576001 4134574 4159216 GO:0006436 tryptophanyl-tRNA aminoacylation The process of coupling tryptophan to tryptophanyl-tRNA, catalyzed by tryptophanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr). IEA GO:0004831 tyrosine-tRNA ligase activity GSVIVG01020576001 4134574 4159216 GO:0006437 tyrosyl-tRNA aminoacylation The process of coupling tyrosine to tyrosyl-tRNA, catalyzed by tyrosyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr). IEA GO:0004831 tyrosine-tRNA ligase activity GSVIVG01020576001 4134574 4159216 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020576001 4134574 4159216 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020576001 4134574 4159216 GO:0006436 tryptophanyl-tRNA aminoacylation The process of coupling tryptophan to tryptophanyl-tRNA, catalyzed by tryptophanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020576001 4134574 4159216 GO:0006437 tyrosyl-tRNA aminoacylation The process of coupling tyrosine to tyrosyl-tRNA, catalyzed by tyrosyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020576001 4134574 4159216 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01020576001 4134574 4159216 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01020576001 4134574 4159216 GO:0006436 tryptophanyl-tRNA aminoacylation The process of coupling tryptophan to tryptophanyl-tRNA, catalyzed by tryptophanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01020576001 4134574 4159216 GO:0006437 tyrosyl-tRNA aminoacylation The process of coupling tyrosine to tyrosyl-tRNA, catalyzed by tyrosyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01030418001 5420974 5423145 GSVIVG01027222001 17907431 18008934 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01027222001 17907431 18008934 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01027222001 17907431 18008934 GO:0006438 valyl-tRNA aminoacylation The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01027222001 17907431 18008934 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01027222001 17907431 18008934 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01027222001 17907431 18008934 GO:0006438 valyl-tRNA aminoacylation The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01027222001 17907431 18008934 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val). IEA GO:0004832 valine-tRNA ligase activity GSVIVG01027222001 17907431 18008934 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val). IEA GO:0004832 valine-tRNA ligase activity GSVIVG01027222001 17907431 18008934 GO:0006438 valyl-tRNA aminoacylation The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val). IEA GO:0004832 valine-tRNA ligase activity GSVIVG01027222001 17907431 18008934 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027222001 17907431 18008934 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027222001 17907431 18008934 GO:0006438 valyl-tRNA aminoacylation The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020359001 20595962 20596458 GSVIVG01035409001 1079723 1090460 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01035409001 1079723 1090460 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01035409001 1079723 1090460 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01035409001 1079723 1090460 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026400001 15655571 15657133 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01026400001 15655571 15657133 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01026400001 15655571 15657133 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01026400001 15655571 15657133 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01004701001 15290002 15292412 GSVIVG01020745001 2410313 2411923 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01020745001 2410313 2411923 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01020745001 2410313 2411923 Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01006452001 26090033 26092462 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007169001 30630873 30631718 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007169001 30630873 30631718 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007169001 30630873 30631718 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007169001 30630873 30631718 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01007169001 30630873 30631718 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01007169001 30630873 30631718 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01007169001 30630873 30631718 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01007169001 30630873 30631718 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01007169001 30630873 30631718 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01007169001 30630873 30631718 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01007169001 30630873 30631718 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01007169001 30630873 30631718 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01007169001 30630873 30631718 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01007169001 30630873 30631718 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01007169001 30630873 30631718 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01007733001 9805985 9812712 GO:0006820 anion transport The directed movement of anions, atoms or small molecules with a net negative charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA IEA GO:0005452 inorganic anion exchanger activity GSVIVG01007733001 9805985 9812712 GO:0006820 anion transport The directed movement of anions, atoms or small molecules with a net negative charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA IEA GO:0005452 inorganic anion exchanger activity GSVIVG01007733001 9805985 9812712 GO:0006820 anion transport The directed movement of anions, atoms or small molecules with a net negative charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA IEA GO:0015380 anion exchanger activity GSVIVG01007733001 9805985 9812712 GO:0006820 anion transport The directed movement of anions, atoms or small molecules with a net negative charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA IEA GO:0015380 anion exchanger activity GSVIVG01004843001 5599006 5602022 GSVIVG01025950001 26773222 26795516 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025950001 26773222 26795516 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025950001 26773222 26795516 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01025950001 26773222 26795516 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. IEA GO:0048037 cofactor binding GSVIVG01025950001 26773222 26795516 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01013393001 745957 749097 GSVIVG01011504001 30082284 30107432 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: 1,4-alpha-D-glucosyl(n) + phosphate = 1,4-alpha-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate. The name should be qualified in each instance by adding the name of the natural substrate, e.g. maltodextrin phosphorylase, starch phosphorylase, glycogen phosphorylase. IEA GO:0004645 phosphorylase activity GSVIVG01011504001 30082284 30107432 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01038555001 21873517 21906584 GO:0051276 chromosome organization A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01038555001 21873517 21906584 GO:0051276 chromosome organization A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000259001 20634446 20654932 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000259001 20634446 20654932 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). IEA GO:0016769 transferase activity, transferring nitrogenous groups GSVIVG01000259001 20634446 20654932 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01017752001 3151744 3155599 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01034708001 8147774 8148355 GSVIVG01010754001 22200689 22202305 GSVIVG01037446001 13605056 13610642 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01037446001 13605056 13610642 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01037446001 13605056 13610642 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01037446001 13605056 13610642 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01037446001 13605056 13610642 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016860001 2064010 2066136 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01005137001 18493983 18497617 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Enables the directed movement of acyl groups into, out of, within or between cells. IEA GO:0000036 acyl carrier activity GSVIVG01005137001 18493983 18497617 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. IEA GO:0048037 cofactor binding GSVIVG01013906001 6641171 6642854 GSVIVG01018486001 14419741 14420915 GSVIVG01020795001 1898008 1903579 GSVIVG01031869001 5006520 5008252 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01031869001 5006520 5008252 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01031869001 5006520 5008252 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01031869001 5006520 5008252 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01023036001 16561945 16567192 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01023036001 16561945 16567192 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01010745001 22071839 22077330 GSVIVG01018783001 19868019 19922607 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01018783001 19868019 19922607 Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01035977001 6710110 6726284 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01035977001 6710110 6726284 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035977001 6710110 6726284 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity. IEA GO:0004721 phosphoprotein phosphatase activity GSVIVG01035977001 6710110 6726284 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. IEA GO:0004722 protein serine/threonine phosphatase activity GSVIVG01035977001 6710110 6726284 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01035977001 6710110 6726284 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01030829001 17076607 17077705 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01030428001 5480518 5485698 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid. IEA GO:0008378 galactosyltransferase activity GSVIVG01024458001 2823521 2823727 GSVIVG01027842001 8521274 8525357 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027500001 16177741 16179912 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027500001 16177741 16179912 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain. IEA GO:0004177 aminopeptidase activity GSVIVG01001502001 5174902 5175984 GSVIVG01008241001 4225513 4226967 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01030278001 9604906 9607715 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01030278001 9604906 9607715 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01028381001 6847284 6850169 GSVIVG01038679001 21050289 21051593 GSVIVG01010794001 22643832 22646892 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01000079001 3275680 3286977 GO:0009987 cellular process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01038073001 17427977 17439967 GO:0006367 transcription initiation from RNA polymerase II promoter A transcription initiation process that results in RNA synthesis by RNA polymerase II. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01038073001 17427977 17439967 GO:0006367 transcription initiation from RNA polymerase II promoter A transcription initiation process that results in RNA synthesis by RNA polymerase II. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Functions to initiate or regulate RNA polymerase II transcription. IEA GO:0003702 RNA polymerase II transcription factor activity GSVIVG01021313001 3883061 3911610 GO:0005992 trehalose biosynthetic process The chemical reactions and pathways resulting in the formation of trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031092001 2453955 2459040 GSVIVG01025608001 13642556 13644731 GSVIVG01014364001 3038731 3047932 GSVIVG01002962001 37451069 37452531 GSVIVG01022159001 17132819 17136150 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01022159001 17132819 17136150 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01022159001 17132819 17136150 GO:0008272 sulfate transport The directed movement of sulfate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01022159001 17132819 17136150 GO:0008272 sulfate transport The directed movement of sulfate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01022159001 17132819 17136150 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01022159001 17132819 17136150 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01022159001 17132819 17136150 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01022159001 17132819 17136150 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01022159001 17132819 17136150 GO:0008272 sulfate transport The directed movement of sulfate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01022159001 17132819 17136150 GO:0008272 sulfate transport The directed movement of sulfate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01022159001 17132819 17136150 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01022159001 17132819 17136150 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01008816001 2415458 2417215 GSVIVG01003705001 15199647 15227264 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GSVIVG01009055001 4595726 4599044 GSVIVG01011683001 5136641 5138777 GSVIVG01002058001 32528157 32532038 GSVIVG01000623001 14064459 14074173 GSVIVG01000211001 16116975 16119503 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01000211001 16116975 16119503 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01000211001 16116975 16119503 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01000211001 16116975 16119503 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01000211001 16116975 16119503 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030878001 18275529 18278404 GSVIVG01006098001 41438476 41440890 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01009465001 8597932 8600974 GSVIVG01020933001 16931580 16942505 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020933001 16931580 16942505 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020933001 16931580 16942505 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020933001 16931580 16942505 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020933001 16931580 16942505 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020933001 16931580 16942505 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020933001 16931580 16942505 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01020933001 16931580 16942505 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01020933001 16931580 16942505 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01020933001 16931580 16942505 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01020933001 16931580 16942505 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01020933001 16931580 16942505 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01020933001 16931580 16942505 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01020933001 16931580 16942505 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01020933001 16931580 16942505 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01020933001 16931580 16942505 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01020933001 16931580 16942505 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01020933001 16931580 16942505 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01020933001 16931580 16942505 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. IEA GO:0005179 hormone activity GSVIVG01020933001 16931580 16942505 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. IEA GO:0005179 hormone activity GSVIVG01020933001 16931580 16942505 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. IEA GO:0005179 hormone activity GSVIVG01020933001 16931580 16942505 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. IEA GO:0005179 hormone activity GSVIVG01020933001 16931580 16942505 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. IEA GO:0005179 hormone activity GSVIVG01020933001 16931580 16942505 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. IEA GO:0005179 hormone activity GSVIVG01020933001 16931580 16942505 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01020933001 16931580 16942505 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01020933001 16931580 16942505 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01020933001 16931580 16942505 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01020933001 16931580 16942505 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01020933001 16931580 16942505 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01037260001 16796502 16815796 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01037260001 16796502 16815796 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01037260001 16796502 16815796 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01037260001 16796502 16815796 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01037260001 16796502 16815796 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01037260001 16796502 16815796 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01033205001 9696115 9697625 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin. IEA GO:0004221 ubiquitin thiolesterase activity GSVIVG01008445001 1971633 1993484 GO:0000723 telomere maintenance Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences. IEA GO:0000784 nuclear chromosome, telomeric region The terminal region of a linear chromosome in the nucleus that includes the telomeric DNA repeats and associated proteins. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01022729001 15718087 15722400 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01022729001 15718087 15722400 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01022729001 15718087 15722400 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010568001 16526032 16527942 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010568001 16526032 16527942 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010568001 16526032 16527942 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01010568001 16526032 16527942 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01012378001 271853 274209 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012378001 271853 274209 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012378001 271853 274209 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01012378001 271853 274209 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01012378001 271853 274209 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01012378001 271853 274209 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01014844001 10503115 10505322 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01028110001 3881484 3883818 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01026633001 20885557 20887126 GSVIVG01025061001 4838277 4845016 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01025061001 4838277 4845016 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01025061001 4838277 4845016 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01025061001 4838277 4845016 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034636001 13614423 13618523 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01034636001 13614423 13618523 Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01000842001 2799300 2821807 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000842001 2799300 2821807 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000842001 2799300 2821807 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000842001 2799300 2821807 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029055001 11545076 11551320 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01029055001 11545076 11551320 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01029055001 11545076 11551320 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01029055001 11545076 11551320 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014291001 2368390 2369358 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01014291001 2368390 2369358 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01014291001 2368390 2369358 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01014291001 2368390 2369358 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01014291001 2368390 2369358 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01014291001 2368390 2369358 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01014291001 2368390 2369358 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01014291001 2368390 2369358 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01014291001 2368390 2369358 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01014291001 2368390 2369358 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01014291001 2368390 2369358 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01014291001 2368390 2369358 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01014291001 2368390 2369358 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01014291001 2368390 2369358 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01014291001 2368390 2369358 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01000423001 7768053 7769470 GSVIVG01018118001 6694357 6698226 GSVIVG01021190001 2445917 2449677 GSVIVG01028736001 19262281 19270069 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032695001 1453840 1454926 GSVIVG01021909001 5734804 5735795 GSVIVG01031244001 876681 895838 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01001748001 729142 730644 GSVIVG01038795001 1089576 1119807 GSVIVG01032802001 619988 633386 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01009581001 9614105 9619838 GSVIVG01011060001 1890987 1892976 GSVIVG01012227001 419906 428372 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01012227001 419906 428372 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01018819001 19607425 19615893 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0008236 serine-type peptidase activity GSVIVG01019043001 17429918 17436016 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019043001 17429918 17436016 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0019028 viral capsid The protein coat that surrounds the infective nucleic acid in some virus particles. It comprises numerous regularly arranged subunits, or capsomeres. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019043001 17429918 17436016 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019043001 17429918 17436016 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0019028 viral capsid The protein coat that surrounds the infective nucleic acid in some virus particles. It comprises numerous regularly arranged subunits, or capsomeres. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019043001 17429918 17436016 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01019043001 17429918 17436016 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0019028 viral capsid The protein coat that surrounds the infective nucleic acid in some virus particles. It comprises numerous regularly arranged subunits, or capsomeres. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01019043001 17429918 17436016 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01019043001 17429918 17436016 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0019028 viral capsid The protein coat that surrounds the infective nucleic acid in some virus particles. It comprises numerous regularly arranged subunits, or capsomeres. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01019043001 17429918 17436016 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01019043001 17429918 17436016 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0019028 viral capsid The protein coat that surrounds the infective nucleic acid in some virus particles. It comprises numerous regularly arranged subunits, or capsomeres. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01019043001 17429918 17436016 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01019043001 17429918 17436016 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0019028 viral capsid The protein coat that surrounds the infective nucleic acid in some virus particles. It comprises numerous regularly arranged subunits, or capsomeres. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01019043001 17429918 17436016 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01019043001 17429918 17436016 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0019028 viral capsid The protein coat that surrounds the infective nucleic acid in some virus particles. It comprises numerous regularly arranged subunits, or capsomeres. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01019043001 17429918 17436016 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01019043001 17429918 17436016 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0019028 viral capsid The protein coat that surrounds the infective nucleic acid in some virus particles. It comprises numerous regularly arranged subunits, or capsomeres. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01014721001 8962812 8965954 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01014721001 8962812 8965954 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01014721001 8962812 8965954 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01014721001 8962812 8965954 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01014721001 8962812 8965954 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01014721001 8962812 8965954 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01023210001 21046696 21054184 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023210001 21046696 21054184 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023210001 21046696 21054184 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023210001 21046696 21054184 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037037001 8657005 8658460 GSVIVG01023539001 10040315 10041574 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01023539001 10040315 10041574 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01023539001 10040315 10041574 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01023539001 10040315 10041574 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023539001 10040315 10041574 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01004966001 17121804 17126742 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016651 oxidoreductase activity, acting on NADH or NADPH GSVIVG01004966001 17121804 17126742 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds. IEA GO:0048038 quinone binding GSVIVG01004966001 17121804 17126742 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01023566001 9519294 9524919 GSVIVG01038550001 21939676 21947283 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01038550001 21939676 21947283 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01038550001 21939676 21947283 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01038550001 21939676 21947283 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01038550001 21939676 21947283 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01038550001 21939676 21947283 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01038550001 21939676 21947283 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038550001 21939676 21947283 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038550001 21939676 21947283 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01038550001 21939676 21947283 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01038550001 21939676 21947283 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01038550001 21939676 21947283 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01028965001 17025240 17025790 GSVIVG01036999001 9109632 9110250 GSVIVG01032605001 28776098 28778855 GSVIVG01030448001 5638289 5638931 GSVIVG01020362001 20535309 20537409 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01020362001 20535309 20537409 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01036137001 20262007 20263157 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01036137001 20262007 20263157 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01036137001 20262007 20263157 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01036137001 20262007 20263157 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01003566001 14712959 14715723 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01003566001 14712959 14715723 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01003566001 14712959 14715723 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01003566001 14712959 14715723 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01003566001 14712959 14715723 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003566001 14712959 14715723 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003566001 14712959 14715723 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01003566001 14712959 14715723 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01037241001 16987384 16989736 GSVIVG01029472001 22464115 22464370 GSVIVG01016634001 2315197 2317929 GSVIVG01012776001 23429216 23433809 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01012776001 23429216 23433809 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012776001 23429216 23433809 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012776001 23429216 23433809 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01012776001 23429216 23433809 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01036673001 20087916 20096233 GSVIVG01036248001 8127494 8132730 GSVIVG01028166001 4347959 4350752 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA GSVIVG01028166001 4347959 4350752 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GSVIVG01010574001 16503636 16504625 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010574001 16503636 16504625 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010574001 16503636 16504625 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010574001 16503636 16504625 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01010574001 16503636 16504625 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01010574001 16503636 16504625 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01010574001 16503636 16504625 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01010574001 16503636 16504625 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01010574001 16503636 16504625 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01010574001 16503636 16504625 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01010574001 16503636 16504625 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01010574001 16503636 16504625 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01014850001 10550626 10562773 GSVIVG01036842001 17868092 17887668 GSVIVG01001332001 297660 312015 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01001332001 297660 312015 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01022627001 13720783 13721456 GSVIVG01004911001 4748585 4752156 GO:0006546 glycine catabolic process The chemical reactions and pathways resulting in the breakdown of glycine, aminoethanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: (6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein = (6R)-5,10-methylenetetrahydrofolate + NH3 + dihydrolipoylprotein. IEA GO:0004047 aminomethyltransferase activity GSVIVG01036116001 20512527 20529182 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030127 COPII vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036116001 20512527 20529182 GO:0006888 ER to Golgi vesicle-mediated transport The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi. IEA GO:0030127 COPII vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036116001 20512527 20529182 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030127 COPII vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01036116001 20512527 20529182 GO:0006888 ER to Golgi vesicle-mediated transport The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi. IEA GO:0030127 COPII vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01011781001 4194983 4204540 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01011781001 4194983 4204540 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01011781001 4194983 4204540 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01011781001 4194983 4204540 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01011781001 4194983 4204540 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01011781001 4194983 4204540 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01011781001 4194983 4204540 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01011781001 4194983 4204540 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01011781001 4194983 4204540 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01011781001 4194983 4204540 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01011781001 4194983 4204540 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01011781001 4194983 4204540 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01011781001 4194983 4204540 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01011781001 4194983 4204540 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01011781001 4194983 4204540 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01011781001 4194983 4204540 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01011781001 4194983 4204540 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA A ligand-dependent receptor found in the nucleus of the cell. IEA GO:0004879 ligand-dependent nuclear receptor activity GSVIVG01011781001 4194983 4204540 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A ligand-dependent receptor found in the nucleus of the cell. IEA GO:0004879 ligand-dependent nuclear receptor activity GSVIVG01011781001 4194983 4204540 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA A ligand-dependent receptor found in the nucleus of the cell. IEA GO:0004879 ligand-dependent nuclear receptor activity GSVIVG01011781001 4194983 4204540 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A ligand-dependent receptor found in the nucleus of the cell. IEA GO:0004879 ligand-dependent nuclear receptor activity GSVIVG01011781001 4194983 4204540 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011781001 4194983 4204540 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011781001 4194983 4204540 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011781001 4194983 4204540 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011781001 4194983 4204540 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01011781001 4194983 4204540 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01011781001 4194983 4204540 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01011781001 4194983 4204540 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01011781001 4194983 4204540 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01011781001 4194983 4204540 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01011781001 4194983 4204540 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01011781001 4194983 4204540 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01029110001 19584424 19585810 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0005839 proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. IEA Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. IEA GO:0004298 threonine-type endopeptidase activity GSVIVG01016479001 3514966 3523538 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01000922001 21924403 21931626 GSVIVG01033867001 17155145 17158628 GSVIVG01027881001 8958785 8963415 GSVIVG01018936001 18537011 18542602 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018936001 18537011 18542602 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nucleotidyl group to a reactant. IEA GO:0016779 nucleotidyltransferase activity GSVIVG01031613001 18933764 18935456 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01027998001 3100942 3101197 GSVIVG01016332001 4961089 4962007 GSVIVG01002793001 36452161 36455098 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme. IEA GO:0004867 serine-type endopeptidase inhibitor activity GSVIVG01002793001 36452161 36455098 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme. IEA GO:0004867 serine-type endopeptidase inhibitor activity GSVIVG01002793001 36452161 36455098 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme. IEA GO:0004867 serine-type endopeptidase inhibitor activity GSVIVG01002793001 36452161 36455098 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme. IEA GO:0004867 serine-type endopeptidase inhibitor activity GSVIVG01002793001 36452161 36455098 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01002793001 36452161 36455098 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01002793001 36452161 36455098 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01002793001 36452161 36455098 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01002793001 36452161 36455098 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01002793001 36452161 36455098 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01002793001 36452161 36455098 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01002793001 36452161 36455098 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01015049001 713295 714860 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01015049001 713295 714860 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012159001 961115 963805 GSVIVG01032811001 571432 576350 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032811001 571432 576350 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01032811001 571432 576350 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01003976001 26425345 26427642 GSVIVG01015365001 3037191 3044015 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01015365001 3037191 3044015 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01015365001 3037191 3044015 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01015365001 3037191 3044015 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01037737001 7378799 7386028 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01037737001 7378799 7386028 GO:0051090 regulation of transcription factor activity Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01037737001 7378799 7386028 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Functions to initiate or regulate RNA polymerase II transcription. IEA GO:0003702 RNA polymerase II transcription factor activity GSVIVG01037737001 7378799 7386028 GO:0051090 regulation of transcription factor activity Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Functions to initiate or regulate RNA polymerase II transcription. IEA GO:0003702 RNA polymerase II transcription factor activity GSVIVG01037737001 7378799 7386028 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01037737001 7378799 7386028 GO:0051090 regulation of transcription factor activity Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01037737001 7378799 7386028 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA IEA GO:0016986 transcription initiation factor activity GSVIVG01037737001 7378799 7386028 GO:0051090 regulation of transcription factor activity Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA IEA GO:0016986 transcription initiation factor activity GSVIVG01036680001 23998364 23999284 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01027173001 17253433 17257050 GSVIVG01015097001 1027464 1031656 GO:0006357 regulation of transcription from RNA polymerase II promoter Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. IEA GO:0016592 mediator complex A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. IEA Functions to mediate the interaction of transcriptional activators with the RNA polymerase II-general RNA polymerase II transcription factor complex. IEA GO:0016455 RNA polymerase II transcription mediator activity GSVIVG01034693001 7821358 7822034 GSVIVG01008472001 1630709 1633977 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01008472001 1630709 1633977 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01008472001 1630709 1633977 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018543001 13618889 13620356 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01018543001 13618889 13620356 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01018543001 13618889 13620356 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01018543001 13618889 13620356 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01020732001 2547189 2568744 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01020732001 2547189 2568744 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01020732001 2547189 2568744 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01020732001 2547189 2568744 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020732001 2547189 2568744 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021892001 5980969 5983731 GSVIVG01024062001 1424547 1429397 Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01019512001 1230451 1235851 GSVIVG01031274001 656995 659045 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01024953001 5713181 5714445 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01024590001 8595215 8596367 GSVIVG01031856001 4940439 4942521 Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01031856001 4940439 4942521 Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01031856001 4940439 4942521 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01031856001 4940439 4942521 Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01017841001 3947364 3955722 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01017841001 3947364 3955722 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01017841001 3947364 3955722 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. IEA GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GSVIVG01017841001 3947364 3955722 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species. IEA GO:0031418 L-ascorbic acid binding GSVIVG01032740001 1138151 1148273 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01032740001 1138151 1148273 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01032740001 1138151 1148273 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01032740001 1138151 1148273 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032740001 1138151 1148273 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003084001 8494374 8495109 GO:0007205 activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway The initiation of the activity of the inactive enzyme protein kinase C as the result of a series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol 3-phosphate. IEA GO:0004143 diacylglycerol kinase activity GSVIVG01001940001 15048793 15073575 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01001940001 15048793 15073575 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01001940001 15048793 15073575 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01001940001 15048793 15073575 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01017974001 5209750 5212723 GSVIVG01034198001 14493878 14509826 GSVIVG01000149001 15656490 15669801 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01000149001 15656490 15669801 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01000149001 15656490 15669801 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01000149001 15656490 15669801 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01000149001 15656490 15669801 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022912001 18122920 18131267 GSVIVG01009881001 12086190 12090998 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009881001 12086190 12090998 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01018625001 12049723 12054218 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01018625001 12049723 12054218 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01018625001 12049723 12054218 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01018625001 12049723 12054218 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01018625001 12049723 12054218 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01018625001 12049723 12054218 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01023748001 10569908 10579203 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023748001 10569908 10579203 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023748001 10569908 10579203 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023748001 10569908 10579203 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023748001 10569908 10579203 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023748001 10569908 10579203 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023748001 10569908 10579203 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01023748001 10569908 10579203 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01036983001 9274593 9285508 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01036983001 9274593 9285508 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01036983001 9274593 9285508 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. IEA GO:0008483 transaminase activity GSVIVG01036983001 9274593 9285508 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. IEA GO:0008483 transaminase activity GSVIVG01036983001 9274593 9285508 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). IEA GO:0016769 transferase activity, transferring nitrogenous groups GSVIVG01036983001 9274593 9285508 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). IEA GO:0016769 transferase activity, transferring nitrogenous groups GSVIVG01036983001 9274593 9285508 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01036983001 9274593 9285508 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01016853001 1981228 1986351 GSVIVG01030964001 19819492 19820648 GSVIVG01030018001 8959646 8966657 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01003318001 9003000 9004118 GSVIVG01022976001 17353248 17373813 GSVIVG01028662001 11795246 11800378 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01028662001 11795246 11800378 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01028662001 11795246 11800378 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01028662001 11795246 11800378 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01028662001 11795246 11800378 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025255001 2665995 2667367 GSVIVG01005271001 20103623 20105915 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01005271001 20103623 20105915 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01008557001 895127 901496 GSVIVG01025755001 12194179 12203721 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025755001 12194179 12203721 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025755001 12194179 12203721 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01025755001 12194179 12203721 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01025755001 12194179 12203721 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025755001 12194179 12203721 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025755001 12194179 12203721 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025755001 12194179 12203721 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01019816001 3566593 3568188 GSVIVG01034679001 7541221 7549013 GSVIVG01009424001 8236350 8237760 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035441001 1288746 1290719 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035441001 1288746 1290719 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01002018001 32317828 32323009 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Functions to initiate or regulate RNA polymerase II transcription. IEA GO:0003702 RNA polymerase II transcription factor activity GSVIVG01002018001 32317828 32323009 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Functions to initiate or regulate RNA polymerase II transcription. IEA GO:0003702 RNA polymerase II transcription factor activity GSVIVG01032920001 24129503 24145859 GSVIVG01029894001 1032372 1034024 GSVIVG01021969001 4966373 4971320 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Enables the directed movement of acyl groups into, out of, within or between cells. IEA GO:0000036 acyl carrier activity GSVIVG01021969001 4966373 4971320 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Enables the directed movement of acyl groups into, out of, within or between cells. IEA GO:0000036 acyl carrier activity GSVIVG01021969001 4966373 4971320 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Interacting selectizely with phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate). IEA GO:0031177 phosphopantetheine binding GSVIVG01021969001 4966373 4971320 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Interacting selectizely with phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate). IEA GO:0031177 phosphopantetheine binding GSVIVG01021969001 4966373 4971320 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. IEA GO:0048037 cofactor binding GSVIVG01021969001 4966373 4971320 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. IEA GO:0048037 cofactor binding GSVIVG01036955001 9675335 9678621 GSVIVG01007989001 6879840 6886156 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01007989001 6879840 6886156 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01016560001 2772316 2775614 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01016560001 2772316 2775614 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01016560001 2772316 2775614 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01016560001 2772316 2775614 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019136001 16329842 16330786 GSVIVG01016156001 20041837 20046584 GSVIVG01030361001 4982862 4997531 GSVIVG01027301001 16944548 16947225 GSVIVG01023343001 19514984 19533893 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01006351001 25149770 25152979 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01006351001 25149770 25152979 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01006351001 25149770 25152979 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01006351001 25149770 25152979 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01006351001 25149770 25152979 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01006351001 25149770 25152979 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01006351001 25149770 25152979 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01006351001 25149770 25152979 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01006351001 25149770 25152979 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006351001 25149770 25152979 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006351001 25149770 25152979 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01006351001 25149770 25152979 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01037517001 12355484 12355564 GSVIVG01014683001 8590711 8591677 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01014511001 4666153 4667112 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014511001 4666153 4667112 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014511001 4666153 4667112 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014511001 4666153 4667112 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014511001 4666153 4667112 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014511001 4666153 4667112 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014511001 4666153 4667112 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014511001 4666153 4667112 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014511001 4666153 4667112 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01014511001 4666153 4667112 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01019278001 2106252 2106491 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01019278001 2106252 2106491 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01019278001 2106252 2106491 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01019278001 2106252 2106491 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01019278001 2106252 2106491 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01019278001 2106252 2106491 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01019278001 2106252 2106491 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01019278001 2106252 2106491 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01019278001 2106252 2106491 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01019278001 2106252 2106491 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01019278001 2106252 2106491 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01019278001 2106252 2106491 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01019278001 2106252 2106491 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01019278001 2106252 2106491 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01019278001 2106252 2106491 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01019278001 2106252 2106491 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01019278001 2106252 2106491 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01019278001 2106252 2106491 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01025064001 4822460 4826371 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025064001 4822460 4826371 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA. IEA GO:0004540 ribonuclease activity GSVIVG01015490001 4157305 4178349 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01016716001 563058 579283 GSVIVG01015361001 2982015 2991814 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01015361001 2982015 2991814 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01015361001 2982015 2991814 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01015361001 2982015 2991814 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01002945001 37297991 37298975 GSVIVG01018948001 18439821 18444620 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018948001 18439821 18444620 GO:0006284 base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026965001 18957231 18958817 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01026965001 18957231 18958817 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01030639001 7356469 7357512 Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01030639001 7356469 7357512 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01007329001 31395801 31397490 GSVIVG01030762001 15506673 15507026 GSVIVG01001407001 18753632 18756450 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012257001 48574 58015 Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01015958001 16169584 16171633 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. IEA GO:0008080 N-acetyltransferase activity GSVIVG01019444001 722227 726962 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01021618001 8217247 8226450 GSVIVG01033783001 17860144 17869310 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01014753001 9245112 9251543 GSVIVG01021581001 7407352 7407906 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and carries out proton transport across a membrane. The proton-transporting domain (F0, V0, or A0) includes integral and peripheral membrane proteins. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01021581001 7407352 7407906 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o) All non-F1 subunits of a hydrogen-transporting ATP synthase, including integral and peripheral membrane proteins. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01036640001 19555504 19566405 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01036640001 19555504 19566405 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end. IEA GO:0004527 exonuclease activity GSVIVG01009837001 11698060 11699721 GSVIVG01035697001 3401677 3401950 GSVIVG01031217001 1109542 1112526 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+. IEA GO:0004148 dihydrolipoyl dehydrogenase activity GSVIVG01031217001 1109542 1112526 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031217001 1109542 1112526 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01024033001 1612329 1639335 GO:0006464 protein modification process The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024033001 1612329 1639335 GO:0006464 protein modification process The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. IEA GO:0016881 acid-amino acid ligase activity GSVIVG01032679001 1584030 1585119 GSVIVG01009765001 11106837 11117007 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01009765001 11106837 11117007 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01009765001 11106837 11117007 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035614001 2730001 2731754 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01035614001 2730001 2731754 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01035614001 2730001 2731754 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01027262001 17504465 17505580 GSVIVG01037101001 29118292 29129881 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01037101001 29118292 29129881 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037101001 29118292 29129881 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01037101001 29118292 29129881 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01033058001 25408791 25417963 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GSVIVG01037798001 7831770 7853146 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01037798001 7831770 7853146 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01024882001 6253900 6254504 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024882001 6253900 6254504 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024882001 6253900 6254504 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024882001 6253900 6254504 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024882001 6253900 6254504 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024882001 6253900 6254504 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024882001 6253900 6254504 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01024882001 6253900 6254504 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01024882001 6253900 6254504 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01024882001 6253900 6254504 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024882001 6253900 6254504 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024882001 6253900 6254504 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025332001 1927233 1934853 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Enables the directed movement of acyl groups into, out of, within or between cells. IEA GO:0000036 acyl carrier activity GSVIVG01025332001 1927233 1934853 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Enables the directed movement of acyl groups into, out of, within or between cells. IEA GO:0000036 acyl carrier activity GSVIVG01025332001 1927233 1934853 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Enables the directed movement of acyl groups into, out of, within or between cells. IEA GO:0000036 acyl carrier activity GSVIVG01025332001 1927233 1934853 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025332001 1927233 1934853 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025332001 1927233 1934853 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025332001 1927233 1934853 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: 2 H2O2 = O2 + 2 H2O. IEA GO:0004096 catalase activity GSVIVG01025332001 1927233 1934853 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2 H2O2 = O2 + 2 H2O. IEA GO:0004096 catalase activity GSVIVG01025332001 1927233 1934853 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2 H2O2 = O2 + 2 H2O. IEA GO:0004096 catalase activity GSVIVG01025332001 1927233 1934853 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01025332001 1927233 1934853 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01025332001 1927233 1934853 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01025332001 1927233 1934853 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01025332001 1927233 1934853 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01025332001 1927233 1934853 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01025332001 1927233 1934853 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectizely with phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate). IEA GO:0031177 phosphopantetheine binding GSVIVG01025332001 1927233 1934853 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectizely with phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate). IEA GO:0031177 phosphopantetheine binding GSVIVG01025332001 1927233 1934853 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectizely with phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate). IEA GO:0031177 phosphopantetheine binding GSVIVG01025332001 1927233 1934853 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. IEA GO:0048037 cofactor binding GSVIVG01025332001 1927233 1934853 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. IEA GO:0048037 cofactor binding GSVIVG01025332001 1927233 1934853 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. IEA GO:0048037 cofactor binding GSVIVG01025332001 1927233 1934853 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01025332001 1927233 1934853 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01025332001 1927233 1934853 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01025332001 1927233 1934853 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01025332001 1927233 1934853 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01025332001 1927233 1934853 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01036887001 18191084 18218549 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01036887001 18191084 18218549 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01036887001 18191084 18218549 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036887001 18191084 18218549 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036186001 19693923 19696820 GSVIVG01011760001 4436444 4438194 Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01035476001 1578701 1586803 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01035476001 1578701 1586803 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01035476001 1578701 1586803 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01035476001 1578701 1586803 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035476001 1578701 1586803 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036611001 19167224 19221089 GSVIVG01031238001 959567 961885 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01031238001 959567 961885 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01031238001 959567 961885 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01033293001 21766018 21768686 GO:0006725 cellular aromatic compound metabolic process The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells. IEA Interacting selectively and non-covalently with ferrous iron, Fe(II). IEA GO:0008198 ferrous iron binding GSVIVG01033293001 21766018 21768686 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with ferrous iron, Fe(II). IEA GO:0008198 ferrous iron binding GSVIVG01033293001 21766018 21768686 GO:0006725 cellular aromatic compound metabolic process The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01033293001 21766018 21768686 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01033293001 21766018 21768686 GO:0006725 cellular aromatic compound metabolic process The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033293001 21766018 21768686 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033293001 21766018 21768686 GO:0006725 cellular aromatic compound metabolic process The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and molecular oxygen is incorporated into a donor. IEA GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen GSVIVG01033293001 21766018 21768686 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and molecular oxygen is incorporated into a donor. IEA GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen GSVIVG01003967001 26365546 26378292 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01023227001 20920387 20939460 GO:0006414 translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. IEA GO:0005853 eukaryotic translation elongation factor 1 complex A multisubunit nucleotide exchange complex that binds GTP and aminoacyl-tRNAs, and catalyzes their codon-dependent placement at the A-site of the ribosome. In humans, the complex is composed of four subunits, alpha, beta, delta and gamma. IEA Functions in chain elongation during polypeptide synthesis at the ribosome. IEA GO:0003746 translation elongation factor activity GSVIVG01009612001 9890384 9892193 GSVIVG01022646001 14046369 14046563 GSVIVG01036724001 23284514 23291080 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01036724001 23284514 23291080 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01015438001 3689951 3695195 GSVIVG01017342001 6897832 6900326 GSVIVG01021131001 1724634 1731484 GSVIVG01015137001 1315721 1316852 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01017887001 4355346 4357751 GSVIVG01003654001 11758796 11759098 GSVIVG01008345001 3076361 3086257 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01008345001 3076361 3086257 GO:0019277 UDP-N-acetylgalactosamine biosynthetic process The chemical reactions and pathways resulting in the formation of UDP-N-acetylgalactosamine, a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01008345001 3076361 3086257 GO:0030259 lipid glycosylation Covalent attachment of a glycosyl residue to a lipid molecule. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01008345001 3076361 3086257 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01008345001 3076361 3086257 GO:0019277 UDP-N-acetylgalactosamine biosynthetic process The chemical reactions and pathways resulting in the formation of UDP-N-acetylgalactosamine, a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate. IEA Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01008345001 3076361 3086257 GO:0030259 lipid glycosylation Covalent attachment of a glycosyl residue to a lipid molecule. IEA Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01008345001 3076361 3086257 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol + UDP-N-acetyl-D-glucosamine = GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol + UDP. IEA GO:0050511 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity GSVIVG01008345001 3076361 3086257 GO:0019277 UDP-N-acetylgalactosamine biosynthetic process The chemical reactions and pathways resulting in the formation of UDP-N-acetylgalactosamine, a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate. IEA Catalysis of the reaction: Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol + UDP-N-acetyl-D-glucosamine = GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol + UDP. IEA GO:0050511 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity GSVIVG01008345001 3076361 3086257 GO:0030259 lipid glycosylation Covalent attachment of a glycosyl residue to a lipid molecule. IEA Catalysis of the reaction: Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol + UDP-N-acetyl-D-glucosamine = GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol + UDP. IEA GO:0050511 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity GSVIVG01005913001 22578033 22580210 GO:0016568 chromatin modification The alteration of DNA or protein in chromatin, which may result in changing the chromatin structure. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01005913001 22578033 22580210 GO:0016568 chromatin modification The alteration of DNA or protein in chromatin, which may result in changing the chromatin structure. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives. IEA GO:0018024 histone-lysine N-methyltransferase activity GSVIVG01016927001 2657408 2661233 GO:0006357 regulation of transcription from RNA polymerase II promoter Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. IEA GO:0016592 mediator complex A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. IEA Functions to mediate the interaction of transcriptional activators with the RNA polymerase II-general RNA polymerase II transcription factor complex. IEA GO:0016455 RNA polymerase II transcription mediator activity GSVIVG01002003001 6186659 6188485 GSVIVG01038670001 21089927 21092709 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01038670001 21089927 21092709 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01038670001 21089927 21092709 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ribosomal RNA. IEA GO:0019843 rRNA binding GSVIVG01038670001 21089927 21092709 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with ribosomal RNA. IEA GO:0019843 rRNA binding GSVIVG01012411001 553213 554710 GSVIVG01014497001 4497732 4501094 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014497001 4497732 4501094 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014497001 4497732 4501094 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014497001 4497732 4501094 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014497001 4497732 4501094 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014497001 4497732 4501094 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014497001 4497732 4501094 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014497001 4497732 4501094 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003294001 14246252 14250258 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01003294001 14246252 14250258 GO:0016311 dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01003294001 14246252 14250258 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA Catalysis of the reaction: protein serine/threonine/tyrosine phosphate + H2O = protein serine/threonine/tyrosine + phosphate. IEA GO:0008138 protein tyrosine/serine/threonine phosphatase activity GSVIVG01003294001 14246252 14250258 GO:0016311 dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. IEA Catalysis of the reaction: protein serine/threonine/tyrosine phosphate + H2O = protein serine/threonine/tyrosine + phosphate. IEA GO:0008138 protein tyrosine/serine/threonine phosphatase activity GSVIVG01003294001 14246252 14250258 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. IEA GO:0016791 phosphatase activity GSVIVG01003294001 14246252 14250258 GO:0016311 dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. IEA Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. IEA GO:0016791 phosphatase activity GSVIVG01008900001 3249405 3253155 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008900001 3249405 3253155 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). IEA GO:0016769 transferase activity, transferring nitrogenous groups GSVIVG01008900001 3249405 3253155 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + methylthioadenosine. IEA GO:0016847 1-aminocyclopropane-1-carboxylate synthase activity GSVIVG01008900001 3249405 3253155 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01020640001 3580099 3581768 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01020640001 3580099 3581768 Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. IEA GO:0008171 O-methyltransferase activity GSVIVG01020640001 3580099 3581768 The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01007834001 8583518 8588518 GO:0019028 viral capsid The protein coat that surrounds the infective nucleic acid in some virus particles. It comprises numerous regularly arranged subunits, or capsomeres. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01006353001 25199667 25204831 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01006353001 25199667 25204831 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01006353001 25199667 25204831 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01006353001 25199667 25204831 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01006353001 25199667 25204831 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01006353001 25199667 25204831 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01006353001 25199667 25204831 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01006353001 25199667 25204831 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01006353001 25199667 25204831 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01006353001 25199667 25204831 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01006353001 25199667 25204831 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006353001 25199667 25204831 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01002701001 35925946 35930262 GSVIVG01011217001 9623407 9623643 GSVIVG01018525001 13816501 13816713 GSVIVG01027096001 17979747 17980268 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01016666001 240413 241389 GSVIVG01032287001 14588014 14593039 GSVIVG01031203001 1203196 1204273 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01031203001 1203196 1204273 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01031203001 1203196 1204273 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01011531001 13004264 13012644 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0009707 chloroplast outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the chloroplast envelope. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01011531001 13004264 13012644 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0009707 chloroplast outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the chloroplast envelope. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01011531001 13004264 13012644 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0009707 chloroplast outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the chloroplast envelope. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01011531001 13004264 13012644 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0009707 chloroplast outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the chloroplast envelope. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01017273001 6239561 6244369 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01017273001 6239561 6244369 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01017273001 6239561 6244369 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017273001 6239561 6244369 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017273001 6239561 6244369 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017273001 6239561 6244369 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024668001 7929679 7931739 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01024668001 7929679 7931739 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01024668001 7929679 7931739 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01024668001 7929679 7931739 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01013800001 7453821 7456478 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01014500001 4537166 4555213 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014500001 4537166 4555213 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014500001 4537166 4555213 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014500001 4537166 4555213 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014500001 4537166 4555213 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014500001 4537166 4555213 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014500001 4537166 4555213 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014500001 4537166 4555213 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014500001 4537166 4555213 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01014500001 4537166 4555213 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01033360001 21217306 21220377 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01033832001 17372100 17378057 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01033832001 17372100 17378057 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01033832001 17372100 17378057 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01033832001 17372100 17378057 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01026605001 21129635 21141708 GO:0015886 heme transport The directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells. IEA GO:0015232 heme transporter activity GSVIVG01026605001 21129635 21141708 GO:0017004 cytochrome complex assembly The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells. IEA GO:0015232 heme transporter activity GSVIVG01022066001 16321542 16322503 GSVIVG01025477001 493776 504627 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014572001 5311062 5315097 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01014572001 5311062 5315097 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01014572001 5311062 5315097 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01018628001 12003325 12005697 GO:0005992 trehalose biosynthetic process The chemical reactions and pathways resulting in the formation of trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018628001 12003325 12005697 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01011479001 29950465 29952249 GSVIVG01022081001 16436969 16440701 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01022081001 16436969 16440701 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01031542001 17354470 17358924 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031542001 17354470 17358924 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01031542001 17354470 17358924 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01025381001 1222035 1223772 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01025381001 1222035 1223772 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01025381001 1222035 1223772 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01025381001 1222035 1223772 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025381001 1222035 1223772 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025381001 1222035 1223772 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025381001 1222035 1223772 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01025381001 1222035 1223772 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01025381001 1222035 1223772 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01025381001 1222035 1223772 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01025381001 1222035 1223772 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01025381001 1222035 1223772 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01026016001 25830695 25832659 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01026016001 25830695 25832659 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01026016001 25830695 25832659 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01026016001 25830695 25832659 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026016001 25830695 25832659 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011634001 5722391 5726992 GO:0005992 trehalose biosynthetic process The chemical reactions and pathways resulting in the formation of trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01011634001 5722391 5726992 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015771001 17271807 17276119 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01015771001 17271807 17276119 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015771001 17271807 17276119 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01015771001 17271807 17276119 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01018119001 6700723 6711313 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01018119001 6700723 6711313 GO:0016570 histone modification The covalent alteration of one or more amino acid residues within a histone protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01009555001 9351748 9355161 GO:0006788 heme oxidation The chemical reactions and pathways resulting in the loss of electrons from one or more atoms in heme. IEA Catalysis of the reaction: heme + 3 donor-H2 + 3 O2 = biliverdin + Fe2+ + CO + 3 acceptor + 3 H2O. IEA GO:0004392 heme oxygenase (decyclizing) activity GSVIVG01009555001 9351748 9355161 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: heme + 3 donor-H2 + 3 O2 = biliverdin + Fe2+ + CO + 3 acceptor + 3 H2O. IEA GO:0004392 heme oxygenase (decyclizing) activity GSVIVG01023345001 19497404 19499527 GSVIVG01007748001 9614844 9616885 GSVIVG01002467001 34912226 34918325 GO:0008643 carbohydrate transport The directed movement of carbohydrate into, out of, within or between cells by means of some external agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0000139 Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus. IEA Catalysis of the transfer of a nucleotide-sugar from one side of the membrane to the other. A nucleotide-sugar is any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. IEA GO:0005338 nucleotide-sugar transmembrane transporter activity GSVIVG01002467001 34912226 34918325 GO:0008643 carbohydrate transport The directed movement of carbohydrate into, out of, within or between cells by means of some external agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a nucleotide-sugar from one side of the membrane to the other. A nucleotide-sugar is any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. IEA GO:0005338 nucleotide-sugar transmembrane transporter activity GSVIVG01002467001 34912226 34918325 GO:0015780 nucleotide-sugar transport The directed movement of nucleotide-sugars into, out of, within or between cells by means of some external agent such as a transporter or pore. Nucleotide-sugars are any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. IEA GO:0000139 Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus. IEA Catalysis of the transfer of a nucleotide-sugar from one side of the membrane to the other. A nucleotide-sugar is any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. IEA GO:0005338 nucleotide-sugar transmembrane transporter activity GSVIVG01002467001 34912226 34918325 GO:0015780 nucleotide-sugar transport The directed movement of nucleotide-sugars into, out of, within or between cells by means of some external agent such as a transporter or pore. Nucleotide-sugars are any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a nucleotide-sugar from one side of the membrane to the other. A nucleotide-sugar is any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. IEA GO:0005338 nucleotide-sugar transmembrane transporter activity GSVIVG01002467001 34912226 34918325 GO:0008643 carbohydrate transport The directed movement of carbohydrate into, out of, within or between cells by means of some external agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0000139 Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + H+(out) = sugar(in) + H+(in). IEA GO:0005351 sugar:hydrogen symporter activity GSVIVG01002467001 34912226 34918325 GO:0008643 carbohydrate transport The directed movement of carbohydrate into, out of, within or between cells by means of some external agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + H+(out) = sugar(in) + H+(in). IEA GO:0005351 sugar:hydrogen symporter activity GSVIVG01002467001 34912226 34918325 GO:0015780 nucleotide-sugar transport The directed movement of nucleotide-sugars into, out of, within or between cells by means of some external agent such as a transporter or pore. Nucleotide-sugars are any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. IEA GO:0000139 Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + H+(out) = sugar(in) + H+(in). IEA GO:0005351 sugar:hydrogen symporter activity GSVIVG01002467001 34912226 34918325 GO:0015780 nucleotide-sugar transport The directed movement of nucleotide-sugars into, out of, within or between cells by means of some external agent such as a transporter or pore. Nucleotide-sugars are any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + H+(out) = sugar(in) + H+(in). IEA GO:0005351 sugar:hydrogen symporter activity GSVIVG01033687001 18670797 18688484 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01033687001 18670797 18688484 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01033687001 18670797 18688484 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01033687001 18670797 18688484 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01018750001 20219976 20223806 GSVIVG01006626001 27126125 27137865 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01029292001 17416835 17417210 GSVIVG01029528001 21922910 21925324 GSVIVG01009709001 10663603 10668547 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01038531001 11144133 11163077 GSVIVG01025744001 12303353 12310167 GSVIVG01038190001 24209211 24217405 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032915001 24080146 24090660 GSVIVG01034042001 15631373 15634455 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01023103001 22550160 22577955 GSVIVG01037637001 6436166 6451656 GSVIVG01010931001 15449615 15451000 GSVIVG01016007001 17264350 17270351 GSVIVG01027215001 18090272 18106624 GSVIVG01009070001 4700709 4704806 GO:0009073 aromatic amino acid family biosynthetic process The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). IEA Catalysis of the reaction: phosphoenolpyruvate + D-erythrose 4-phosphate + H2O = 2-dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + phosphate. IEA GO:0003849 3-deoxy-7-phosphoheptulonate synthase activity GSVIVG01008848001 2791846 2798321 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. IEA GO:0016853 isomerase activity GSVIVG01000319001 11335675 11336655 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01010169001 16692430 16716306 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01010169001 16692430 16716306 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01027126001 17628351 17630740 GSVIVG01025817001 11539028 11542274 GSVIVG01030037001 9037307 9044911 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. IEA GO:0008080 N-acetyltransferase activity GSVIVG01008834001 2592421 2602002 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008834001 2592421 2602002 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01008834001 2592421 2602002 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01008834001 2592421 2602002 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01038665001 21116339 21124894 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01038665001 21116339 21124894 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01038665001 21116339 21124894 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008237 metallopeptidase activity GSVIVG01038665001 21116339 21124894 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008237 metallopeptidase activity GSVIVG01038665001 21116339 21124894 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01038665001 21116339 21124894 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01038665001 21116339 21124894 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01038665001 21116339 21124894 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01033324001 21495665 21500510 GO:0006164 purine nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01033324001 21495665 21500510 GO:0006164 purine nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: GTP + IMP + L-aspartate = GDP + phosphate + N6-(1,2-dicarboxyethyl)-AMP. IEA GO:0004019 adenylosuccinate synthase activity GSVIVG01033324001 21495665 21500510 GO:0006164 purine nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01031635001 19290439 19292702 GSVIVG01034960001 455085 464858 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01034960001 455085 464858 GO:0031123 RNA 3'-end processing Any process involved in forming the mature 3' end of an RNA molecule. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01034960001 455085 464858 GO:0043631 RNA polyadenylation The enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01034960001 455085 464858 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the template-independent extension of the 3'- end of an RNA or DNA strand by addition of one adenosine molecule at a time. Cannot initiate a chain 'de novo'. The primer, depending on the source of the enzyme, may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group. IEA GO:0004652 polynucleotide adenylyltransferase activity GSVIVG01034960001 455085 464858 GO:0031123 RNA 3'-end processing Any process involved in forming the mature 3' end of an RNA molecule. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the template-independent extension of the 3'- end of an RNA or DNA strand by addition of one adenosine molecule at a time. Cannot initiate a chain 'de novo'. The primer, depending on the source of the enzyme, may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group. IEA GO:0004652 polynucleotide adenylyltransferase activity GSVIVG01034960001 455085 464858 GO:0043631 RNA polyadenylation The enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the template-independent extension of the 3'- end of an RNA or DNA strand by addition of one adenosine molecule at a time. Cannot initiate a chain 'de novo'. The primer, depending on the source of the enzyme, may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group. IEA GO:0004652 polynucleotide adenylyltransferase activity GSVIVG01034960001 455085 464858 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the transfer of a nucleotidyl group to a reactant. IEA GO:0016779 nucleotidyltransferase activity GSVIVG01034960001 455085 464858 GO:0031123 RNA 3'-end processing Any process involved in forming the mature 3' end of an RNA molecule. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the transfer of a nucleotidyl group to a reactant. IEA GO:0016779 nucleotidyltransferase activity GSVIVG01034960001 455085 464858 GO:0043631 RNA polyadenylation The enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the transfer of a nucleotidyl group to a reactant. IEA GO:0016779 nucleotidyltransferase activity GSVIVG01018395001 9822639 9833736 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01018395001 9822639 9833736 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01038196001 24269391 24270909 GSVIVG01027050001 18356743 18364305 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01027050001 18356743 18364305 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01027050001 18356743 18364305 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01027050001 18356743 18364305 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01027050001 18356743 18364305 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01027050001 18356743 18364305 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01027050001 18356743 18364305 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01027050001 18356743 18364305 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01027050001 18356743 18364305 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01027050001 18356743 18364305 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01027050001 18356743 18364305 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01027050001 18356743 18364305 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01027050001 18356743 18364305 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01027050001 18356743 18364305 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01027050001 18356743 18364305 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01027050001 18356743 18364305 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01027050001 18356743 18364305 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01027050001 18356743 18364305 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01027050001 18356743 18364305 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01027050001 18356743 18364305 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01027050001 18356743 18364305 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01027050001 18356743 18364305 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01027050001 18356743 18364305 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01027050001 18356743 18364305 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01021108001 1495041 1496284 GSVIVG01031515001 17756872 17758459 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01026142001 12870358 12899433 GO:0006207 'de novo' pyrimidine base biosynthetic process The chemical reactions and pathways resulting in the formation of pyrimidine bases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026142001 12870358 12899433 GO:0006222 UMP biosynthetic process The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026142001 12870358 12899433 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026142001 12870358 12899433 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026142001 12870358 12899433 GO:0006207 'de novo' pyrimidine base biosynthetic process The chemical reactions and pathways resulting in the formation of pyrimidine bases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: (S)-dihydroorotate + acceptor = orotate + reduced acceptor. IEA GO:0004152 dihydroorotate dehydrogenase activity GSVIVG01026142001 12870358 12899433 GO:0006222 UMP biosynthetic process The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: (S)-dihydroorotate + acceptor = orotate + reduced acceptor. IEA GO:0004152 dihydroorotate dehydrogenase activity GSVIVG01026142001 12870358 12899433 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: (S)-dihydroorotate + acceptor = orotate + reduced acceptor. IEA GO:0004152 dihydroorotate dehydrogenase activity GSVIVG01026142001 12870358 12899433 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: (S)-dihydroorotate + acceptor = orotate + reduced acceptor. IEA GO:0004152 dihydroorotate dehydrogenase activity GSVIVG01026142001 12870358 12899433 GO:0006207 'de novo' pyrimidine base biosynthetic process The chemical reactions and pathways resulting in the formation of pyrimidine bases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: (S)-dihydroorotate + O2 = orotate + H2O2. IEA GO:0004158 dihydroorotate oxidase activity GSVIVG01026142001 12870358 12899433 GO:0006222 UMP biosynthetic process The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: (S)-dihydroorotate + O2 = orotate + H2O2. IEA GO:0004158 dihydroorotate oxidase activity GSVIVG01026142001 12870358 12899433 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: (S)-dihydroorotate + O2 = orotate + H2O2. IEA GO:0004158 dihydroorotate oxidase activity GSVIVG01026142001 12870358 12899433 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: (S)-dihydroorotate + O2 = orotate + H2O2. IEA GO:0004158 dihydroorotate oxidase activity GSVIVG01006680001 27442748 27444563 GSVIVG01021002001 15553007 15557507 GO:0006621 protein retention in ER lumen The retention in the endoplasmic reticulum (ER) lumen of soluble resident proteins. Sorting receptors retrieve proteins with ER localization signals, such as KDEL and HDEL sequences or some transmembrane domains, that have escaped to the cis-Golgi network and return them to the ER. Abnormally folded proteins and unassembled subunits are also selectively retained in the ER. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with an endoplasmic reticulum (ER) retention sequence, a specific peptide sequence that ensures a protein is retained within the ER. IEA GO:0046923 ER retention sequence binding GSVIVG01024930001 5944546 5950225 GSVIVG01029989001 8726447 8737369 GO:0007205 activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway The initiation of the activity of the inactive enzyme protein kinase C as the result of a series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol 3-phosphate. IEA GO:0004143 diacylglycerol kinase activity GSVIVG01022758001 16187441 16189151 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01008672001 1095419 1099360 GSVIVG01033416001 20880222 20881137 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01033416001 20880222 20881137 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01024555001 8870080 8877476 GSVIVG01037454001 13426165 13465008 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01010143001 16271824 16283640 GSVIVG01034527001 19871854 19873289 GSVIVG01026181001 13497353 13498507 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026264001 15146900 15151225 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01014531001 4866197 4867047 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014531001 4866197 4867047 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014531001 4866197 4867047 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014531001 4866197 4867047 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022573001 5261195 5279690 GSVIVG01025728001 12557550 12568133 GSVIVG01014144001 790484 792820 GSVIVG01014053001 10127600 10130024 GSVIVG01008552001 928686 931518 GO:0007047 cellular cell wall organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA Catalysis of the reaction: UDP-glucose + glycogenin = UDP + glucosylglycogenin. IEA GO:0008466 glycogenin glucosyltransferase activity GSVIVG01008552001 928686 931518 GO:0007047 cellular cell wall organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. IEA GO:0009505 plant-type cell wall A more or less rigid stucture lying outside the cell membrane of a cell and composed of cellulose and pectin and other organic and inorganic substances. IEA Catalysis of the reaction: UDP-glucose + glycogenin = UDP + glucosylglycogenin. IEA GO:0008466 glycogenin glucosyltransferase activity GSVIVG01008552001 928686 931518 GO:0007047 cellular cell wall organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. IEA GO:0030054 cell junction A plasma membrane part that forms a specialized region of connection between two cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix. IEA Catalysis of the reaction: UDP-glucose + glycogenin = UDP + glucosylglycogenin. IEA GO:0008466 glycogenin glucosyltransferase activity GSVIVG01008552001 928686 931518 GO:0030244 cellulose biosynthetic process The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA Catalysis of the reaction: UDP-glucose + glycogenin = UDP + glucosylglycogenin. IEA GO:0008466 glycogenin glucosyltransferase activity GSVIVG01008552001 928686 931518 GO:0030244 cellulose biosynthetic process The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation. IEA GO:0009505 plant-type cell wall A more or less rigid stucture lying outside the cell membrane of a cell and composed of cellulose and pectin and other organic and inorganic substances. IEA Catalysis of the reaction: UDP-glucose + glycogenin = UDP + glucosylglycogenin. IEA GO:0008466 glycogenin glucosyltransferase activity GSVIVG01008552001 928686 931518 GO:0030244 cellulose biosynthetic process The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation. IEA GO:0030054 cell junction A plasma membrane part that forms a specialized region of connection between two cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix. IEA Catalysis of the reaction: UDP-glucose + glycogenin = UDP + glucosylglycogenin. IEA GO:0008466 glycogenin glucosyltransferase activity GSVIVG01008552001 928686 931518 GO:0007047 cellular cell wall organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01008552001 928686 931518 GO:0007047 cellular cell wall organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. IEA GO:0009505 plant-type cell wall A more or less rigid stucture lying outside the cell membrane of a cell and composed of cellulose and pectin and other organic and inorganic substances. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01008552001 928686 931518 GO:0007047 cellular cell wall organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. IEA GO:0030054 cell junction A plasma membrane part that forms a specialized region of connection between two cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01008552001 928686 931518 GO:0030244 cellulose biosynthetic process The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01008552001 928686 931518 GO:0030244 cellulose biosynthetic process The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation. IEA GO:0009505 plant-type cell wall A more or less rigid stucture lying outside the cell membrane of a cell and composed of cellulose and pectin and other organic and inorganic substances. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01008552001 928686 931518 GO:0030244 cellulose biosynthetic process The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation. IEA GO:0030054 cell junction A plasma membrane part that forms a specialized region of connection between two cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01031589001 18545100 18546540 GSVIVG01015994001 16944777 16965960 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015994001 16944777 16965960 Catalysis of the transfer of a functional group from one position to another within a single molecule. IEA GO:0016866 intramolecular transferase activity GSVIVG01028475001 8118659 8137179 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01028475001 8118659 8137179 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds. IEA GO:0015035 protein disulfide oxidoreductase activity GSVIVG01027621001 14983162 14985661 GSVIVG01024407001 2166979 2173836 GO:0001539 ciliary or flagellar motility Cell motility due to movement of cilia or flagella. IEA GO:0009288 bacterial-type flagellum A motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01024407001 2166979 2173836 GO:0001539 ciliary or flagellar motility Cell motility due to movement of cilia or flagella. IEA GO:0009288 bacterial-type flagellum A motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope. IEA Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate. IEA GO:0003774 motor activity GSVIVG01024407001 2166979 2173836 GO:0001539 ciliary or flagellar motility Cell motility due to movement of cilia or flagella. IEA GO:0009288 bacterial-type flagellum A motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024407001 2166979 2173836 GO:0001539 ciliary or flagellar motility Cell motility due to movement of cilia or flagella. IEA GO:0009288 bacterial-type flagellum A motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01032775001 845944 861052 GO:0019867 outer membrane The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites. IEA GSVIVG01026935001 19261317 19266181 GSVIVG01024431001 2483206 2483468 GSVIVG01000442001 8060163 8065442 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017147001 4636388 4637439 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01019154001 16020906 16021763 GSVIVG01014538001 4943927 4947171 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014538001 4943927 4947171 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014538001 4943927 4947171 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014538001 4943927 4947171 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014538001 4943927 4947171 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014538001 4943927 4947171 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014538001 4943927 4947171 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014538001 4943927 4947171 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014538001 4943927 4947171 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014538001 4943927 4947171 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014538001 4943927 4947171 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014538001 4943927 4947171 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014538001 4943927 4947171 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01014538001 4943927 4947171 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01014538001 4943927 4947171 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01014538001 4943927 4947171 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01014538001 4943927 4947171 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01014538001 4943927 4947171 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024838001 6519185 6521679 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of copper (Cu) ions from one side of a membrane to the other. IEA GO:0005375 copper ion transmembrane transporter activity GSVIVG01022970001 17418937 17423581 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01007375001 31593803 31594591 GSVIVG01035716001 3609187 3613291 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01035716001 3609187 3613291 Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01038147001 23888940 23891150 GSVIVG01026187001 13676298 13679717 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01026187001 13676298 13679717 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01026187001 13676298 13679717 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01026187001 13676298 13679717 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01026187001 13676298 13679717 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034336001 17891227 17898196 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with adenosine and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity. IEA GO:0001609 adenosine receptor activity, G-protein coupled GSVIVG01030960001 19709982 19710724 GSVIVG01010967001 2542454 2554694 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01010967001 2542454 2554694 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01010967001 2542454 2554694 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01010967001 2542454 2554694 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01010967001 2542454 2554694 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01010967001 2542454 2554694 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01014458001 3952949 3953062 GSVIVG01026760001 6435722 6464929 GO:0016070 RNA metabolic process The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026760001 6435722 6464929 GO:0016070 RNA metabolic process The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01009789001 11275706 11277358 GSVIVG01009852001 11784344 11786072 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01009852001 11784344 11786072 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01009852001 11784344 11786072 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01009852001 11784344 11786072 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01022885001 18353534 18376509 GO:0006397 mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA GSVIVG01022885001 18353534 18376509 GO:0008380 RNA splicing The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA GSVIVG01037666001 6681567 6685068 GSVIVG01004469001 38713340 38714281 GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA GSVIVG01009336001 7529283 7531698 GO:0006887 exocytosis A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell. This is the process whereby most molecules are secreted from eukaryotic cells. IEA GO:0000145 exocyst A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals. IEA GSVIVG01013394001 740652 743702 GSVIVG01012173001 770020 779392 GSVIVG01032495001 27883437 27884096 GSVIVG01014399001 3368204 3375246 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01014399001 3368204 3375246 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01014399001 3368204 3375246 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01018630001 11982872 11990729 GSVIVG01018292001 11676702 11677926 Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01018292001 11676702 11677926 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01016344001 4778343 4783782 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01032955001 24592270 24604649 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01032955001 24592270 24604649 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01032955001 24592270 24604649 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Interacting selectively and non-covalently with damaged DNA. IEA GO:0003684 damaged DNA binding GSVIVG01032955001 24592270 24604649 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01032955001 24592270 24604649 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032955001 24592270 24604649 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01032955001 24592270 24604649 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01022333001 18575444 18575596 GSVIVG01008569001 812769 813758 GSVIVG01017873001 4205509 4215917 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01017873001 4205509 4215917 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01017873001 4205509 4215917 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli. IEA GO:0004707 MAP kinase activity GSVIVG01017873001 4205509 4215917 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01017873001 4205509 4215917 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031608001 18881483 18890603 GSVIVG01011871001 3379863 3395733 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01011871001 3379863 3395733 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01011871001 3379863 3395733 GO:0006425 glutaminyl-tRNA aminoacylation The process of coupling glutamine to glutaminyl-tRNA, catalyzed by glutaminyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'- adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01011871001 3379863 3395733 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01011871001 3379863 3395733 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01011871001 3379863 3395733 GO:0006425 glutaminyl-tRNA aminoacylation The process of coupling glutamine to glutaminyl-tRNA, catalyzed by glutaminyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'- adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01011871001 3379863 3395733 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln). IEA GO:0004819 glutamine-tRNA ligase activity GSVIVG01011871001 3379863 3395733 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln). IEA GO:0004819 glutamine-tRNA ligase activity GSVIVG01011871001 3379863 3395733 GO:0006425 glutaminyl-tRNA aminoacylation The process of coupling glutamine to glutaminyl-tRNA, catalyzed by glutaminyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'- adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln). IEA GO:0004819 glutamine-tRNA ligase activity GSVIVG01011871001 3379863 3395733 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011871001 3379863 3395733 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011871001 3379863 3395733 GO:0006425 glutaminyl-tRNA aminoacylation The process of coupling glutamine to glutaminyl-tRNA, catalyzed by glutaminyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'- adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01005423001 40211878 40214206 GSVIVG01017544001 10299663 10300332 GSVIVG01029655001 20163225 20165486 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01029655001 20163225 20165486 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01029655001 20163225 20165486 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015934 large ribosomal subunit The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01029655001 20163225 20165486 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01029655001 20163225 20165486 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01029655001 20163225 20165486 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015934 large ribosomal subunit The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01028007001 3146354 3160184 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01028007001 3146354 3160184 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01013411001 631117 634528 GSVIVG01015191001 1679836 1694774 GSVIVG01034559001 19476893 19480968 GO:0009396 folic acid and derivative biosynthetic process The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034559001 19476893 19480968 GO:0009396 folic acid and derivative biosynthetic process The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. IEA Catalysis of the reaction: ATP + 5-formyltetrahydrofolate = ADP + phosphate + 5,10-methenyltetrahydrofolate. IEA GO:0030272 5-formyltetrahydrofolate cyclo-ligase activity GSVIVG01001809001 25992234 25995807 GSVIVG01013621001 1735676 1793223 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01013621001 1735676 1793223 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01013621001 1735676 1793223 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01013621001 1735676 1793223 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013621001 1735676 1793223 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036720001 23341372 23351231 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01036720001 23341372 23351231 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031490001 17984822 17987634 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004185 serine-type carboxypeptidase activity GSVIVG01029526001 21955169 21956545 GSVIVG01019387001 236398 241211 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01019387001 236398 241211 GO:0019941 modification-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01019387001 236398 241211 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01019387001 236398 241211 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01019387001 236398 241211 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01019387001 236398 241211 GO:0019941 modification-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01019387001 236398 241211 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01019387001 236398 241211 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01019387001 236398 241211 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01019387001 236398 241211 GO:0019941 modification-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01019387001 236398 241211 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01019387001 236398 241211 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01035292001 112193 124427 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01026959001 19020506 19030832 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026959001 19020506 19030832 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026959001 19020506 19030832 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01026959001 19020506 19030832 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. IEA GO:0048037 cofactor binding GSVIVG01017926001 4768522 4774313 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01011300001 8055955 8088281 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01011300001 8055955 8088281 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01008949001 3741185 3745653 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01010225001 17913958 17930657 GSVIVG01019755001 2997436 3014259 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019755001 2997436 3014259 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01031903001 5269488 5273645 GSVIVG01006044001 23449201 23466333 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01034588001 14836815 14838727 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01034588001 14836815 14838727 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01019007001 17864804 17876406 GSVIVG01028058001 3499502 3499714 GSVIVG01010750001 22132088 22144271 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01010750001 22132088 22144271 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010750001 22132088 22144271 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01017821001 3754733 3758829 GSVIVG01015099001 1036990 1039454 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01015099001 1036990 1039454 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01015099001 1036990 1039454 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01015099001 1036990 1039454 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01006108001 41602389 41603526 GSVIVG01032548001 28259042 28259932 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005578 proteinaceous extracellular matrix A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01032548001 28259042 28259932 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0031012 extracellular matrix A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as in plants). IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01032548001 28259042 28259932 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005578 proteinaceous extracellular matrix A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01032548001 28259042 28259932 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0031012 extracellular matrix A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as in plants). IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01032548001 28259042 28259932 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005578 proteinaceous extracellular matrix A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008237 metallopeptidase activity GSVIVG01032548001 28259042 28259932 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0031012 extracellular matrix A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as in plants). IEA Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008237 metallopeptidase activity GSVIVG01032548001 28259042 28259932 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005578 proteinaceous extracellular matrix A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008237 metallopeptidase activity GSVIVG01032548001 28259042 28259932 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0031012 extracellular matrix A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as in plants). IEA Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008237 metallopeptidase activity GSVIVG01029459001 22618796 22628665 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01029459001 22618796 22628665 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01029459001 22618796 22628665 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01029459001 22618796 22628665 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01026200001 13977081 13978611 GSVIVG01016956001 2954216 2957776 GSVIVG01022188001 17289600 17299349 GSVIVG01003480001 10633747 10636934 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01003480001 10633747 10636934 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01008615001 394286 397861 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01008615001 394286 397861 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01034615001 14246515 14346957 Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity. IEA GO:0004721 phosphoprotein phosphatase activity GSVIVG01034615001 14246515 14346957 Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01034615001 14246515 14346957 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01034615001 14246515 14346957 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01034615001 14246515 14346957 Interacting selectively and non-covalently with manganese (Mn) ions. IEA GO:0030145 manganese ion binding GSVIVG01012535001 846398 850332 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with transfer RNA. IEA GO:0000049 tRNA binding GSVIVG01012535001 846398 850332 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe). IEA GO:0004826 phenylalanine-tRNA ligase activity GSVIVG01012535001 846398 850332 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036941001 17221575 17235993 GSVIVG01027086001 18041454 18052057 GSVIVG01032135001 22298472 22305768 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01003416001 14791101 14804517 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01003416001 14791101 14804517 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01006594001 26943499 26946619 GSVIVG01018469001 14619418 14619663 GSVIVG01024322001 875609 879847 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01024322001 875609 879847 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01024322001 875609 879847 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid. IEA GO:0008825 cyclopropane-fatty-acyl-phospholipid synthase activity GSVIVG01024322001 875609 879847 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid. IEA GO:0008825 cyclopropane-fatty-acyl-phospholipid synthase activity GSVIVG01030818001 16633818 16634459 GSVIVG01013268001 5915695 5997069 GSVIVG01010669001 15322938 15323937 GSVIVG01021997001 4530840 4544551 GSVIVG01035583001 2494953 2500388 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01035583001 2494953 2500388 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01035583001 2494953 2500388 GO:0006422 aspartyl-tRNA aminoacylation The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01035583001 2494953 2500388 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01035583001 2494953 2500388 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01035583001 2494953 2500388 GO:0006422 aspartyl-tRNA aminoacylation The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01035583001 2494953 2500388 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp). IEA GO:0004815 aspartate-tRNA ligase activity GSVIVG01035583001 2494953 2500388 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp). IEA GO:0004815 aspartate-tRNA ligase activity GSVIVG01035583001 2494953 2500388 GO:0006422 aspartyl-tRNA aminoacylation The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp). IEA GO:0004815 aspartate-tRNA ligase activity GSVIVG01035583001 2494953 2500388 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035583001 2494953 2500388 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035583001 2494953 2500388 GO:0006422 aspartyl-tRNA aminoacylation The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022370001 19169242 19177808 GSVIVG01011355001 28916144 28920647 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004185 serine-type carboxypeptidase activity GSVIVG01027678001 14421991 14432880 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation Splicing of tRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01001753001 6094248 6097776 GSVIVG01026946001 19176176 19182678 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GSVIVG01021628001 8386441 8398886 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01021628001 8386441 8398886 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01011058001 1927188 1929109 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01011058001 1927188 1929109 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01023220001 20975396 20981040 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01023220001 20975396 20981040 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01023220001 20975396 20981040 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01023220001 20975396 20981040 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037458001 13329723 13331092 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009539 photosystem II reaction center An integral membrane complex containing P680, the chlorophyll a molecule that functions as a primary electron donor. In the light, functioning as a water-plastoquinone oxidoreductase, it transfers electrons from water to plastoquinone. IEA GSVIVG01025696001 12885619 12889020 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01025696001 12885619 12889020 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01025696001 12885619 12889020 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01025696001 12885619 12889020 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01025696001 12885619 12889020 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01025696001 12885619 12889020 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01017327001 6760553 6761117 GSVIVG01021459001 5623859 5630081 GSVIVG01017079001 4024160 4026364 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017079001 4024160 4026364 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017079001 4024160 4026364 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017079001 4024160 4026364 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014315001 2576356 2588557 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01014315001 2576356 2588557 GO:0019509 L-methionine salvage from methylthioadenosine The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01014315001 2576356 2588557 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2-phosphoglycolate + H2O = glycolate + phosphate. IEA GO:0008967 phosphoglycolate phosphatase activity GSVIVG01014315001 2576356 2588557 GO:0019509 L-methionine salvage from methylthioadenosine The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine. IEA Catalysis of the reaction: 2-phosphoglycolate + H2O = glycolate + phosphate. IEA GO:0008967 phosphoglycolate phosphatase activity GSVIVG01014315001 2576356 2588557 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reactions: 5-(methylthio)-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate (1a) 5-(methylthio)-2,3-dioxopentyl phosphate = 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate (1b) 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate. IEA GO:0043874 acireductone synthase activity GSVIVG01014315001 2576356 2588557 GO:0019509 L-methionine salvage from methylthioadenosine The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine. IEA Catalysis of the reactions: 5-(methylthio)-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate (1a) 5-(methylthio)-2,3-dioxopentyl phosphate = 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate (1b) 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate. IEA GO:0043874 acireductone synthase activity GSVIVG01014315001 2576356 2588557 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01014315001 2576356 2588557 GO:0019509 L-methionine salvage from methylthioadenosine The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01007848001 8388648 8394515 GO:0006071 glycerol metabolic process The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. IEA Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. IEA GO:0008081 phosphoric diester hydrolase activity GSVIVG01007848001 8388648 8394515 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. IEA GO:0008081 phosphoric diester hydrolase activity GSVIVG01007848001 8388648 8394515 GO:0006071 glycerol metabolic process The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. IEA Catalysis of the reaction: a glycerophosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate. IEA GO:0008889 glycerophosphodiester phosphodiesterase activity GSVIVG01007848001 8388648 8394515 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: a glycerophosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate. IEA GO:0008889 glycerophosphodiester phosphodiesterase activity GSVIVG01011049001 1974454 1974933 GSVIVG01031864001 4986950 4989015 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01031864001 4986950 4989015 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01031864001 4986950 4989015 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01031864001 4986950 4989015 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01017637001 2184079 2194337 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01017637001 2184079 2194337 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01021334001 4181776 4184353 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01021334001 4181776 4184353 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01029247001 18056153 18065881 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor). IEA GO:0004659 prenyltransferase activity GSVIVG01029247001 18056153 18065881 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01000940001 22097588 22099439 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035908001 5662465 5663800 GSVIVG01006784001 28474486 28481092 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01006784001 28474486 28481092 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01006784001 28474486 28481092 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01006784001 28474486 28481092 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01006784001 28474486 28481092 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006784001 28474486 28481092 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006784001 28474486 28481092 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01006784001 28474486 28481092 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01002904001 37151168 37156368 GSVIVG01011734001 4717258 4721940 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01022652001 14141250 14142162 GSVIVG01033516001 20073236 20078134 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01033516001 20073236 20078134 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01033516001 20073236 20078134 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01033516001 20073236 20078134 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01033516001 20073236 20078134 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01033516001 20073236 20078134 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01007819001 8704610 8731895 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007819001 8704610 8731895 GO:0006284 base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01005152001 18674095 18687555 GSVIVG01009294001 7052341 7054311 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01009294001 7052341 7054311 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01029541001 21820739 21824433 GSVIVG01013262001 6121040 6122882 GO:0001932 regulation of protein amino acid phosphorylation Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein. IEA GO:0005952 cAMP-dependent protein kinase complex An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer. IEA Modulation of the activity of the enzyme cAMP-dependent protein kinase. IEA GO:0008603 cAMP-dependent protein kinase regulator activity GSVIVG01013262001 6121040 6122882 GO:0001932 regulation of protein amino acid phosphorylation Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein. IEA GO:0005952 cAMP-dependent protein kinase complex An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01036719001 23353908 23383396 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01036719001 23353908 23383396 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01036719001 23353908 23383396 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. IEA GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor GSVIVG01036719001 23353908 23383396 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. IEA GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor GSVIVG01025644001 13360136 13365111 GSVIVG01007133001 30309518 30310735 GSVIVG01018652001 11630986 11631439 GSVIVG01032646001 1836875 1838279 GSVIVG01037829001 7417454 7418401 GSVIVG01033860001 17187414 17198226 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01033860001 17187414 17198226 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01033860001 17187414 17198226 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033860001 17187414 17198226 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033860001 17187414 17198226 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01033860001 17187414 17198226 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01033860001 17187414 17198226 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01033860001 17187414 17198226 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01033860001 17187414 17198226 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01033860001 17187414 17198226 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01027966001 2865217 2866742 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01017956001 5063542 5068415 GSVIVG01007828001 8621045 8629178 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01007828001 8621045 8629178 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01011913001 3046873 3048873 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01011913001 3046873 3048873 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with the neurotransmitter dopamine to initiate a change in cell activity. IEA GO:0004952 dopamine receptor activity GSVIVG01018757001 20135092 20144011 GO:0008219 cell death A biological process that results in permanent cessation of all vital functions of a cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01025310001 2177506 2186498 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025308001 2218372 2219421 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01027445001 16678948 16681527 GSVIVG01010733001 21896517 21908877 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01010733001 21896517 21908877 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01015153001 1406408 1410665 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01019076001 17021549 17026738 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031180001 1437968 1442240 Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity. IEA GO:0004721 phosphoprotein phosphatase activity GSVIVG01031180001 1437968 1442240 Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01031180001 1437968 1442240 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01009408001 8077180 8078488 GSVIVG01020038001 11257557 11265773 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01032079001 22923457 22923584 GSVIVG01006251001 24083856 24092642 GSVIVG01018080001 6312279 6315782 GSVIVG01025418001 969160 972782 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01025418001 969160 972782 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01025418001 969160 972782 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009168001 5679790 5681129 GSVIVG01029111001 19564657 19565634 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01010259001 18520401 18526595 GSVIVG01023046001 16419970 16426843 GSVIVG01032039001 23284811 23288124 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01032039001 23284811 23288124 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01024433001 2506483 2512220 GSVIVG01031820001 4691610 4693091 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01031820001 4691610 4693091 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01029893001 1023319 1029703 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01036610001 19161292 19167163 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036610001 19161292 19167163 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036610001 19161292 19167163 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036610001 19161292 19167163 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023079001 15655687 15716372 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01023079001 15655687 15716372 GO:0006631 fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01023079001 15655687 15716372 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01023079001 15655687 15716372 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01023079001 15655687 15716372 GO:0006631 fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01023079001 15655687 15716372 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01023079001 15655687 15716372 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01023079001 15655687 15716372 GO:0006631 fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01023079001 15655687 15716372 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01023079001 15655687 15716372 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023079001 15655687 15716372 GO:0006631 fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023079001 15655687 15716372 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023079001 15655687 15716372 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01023079001 15655687 15716372 GO:0006631 fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01023079001 15655687 15716372 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01023079001 15655687 15716372 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: stearoyl-[acyl-carrier protein] + reduced acceptor + O2 = oleoyl-[acyl-carrier protein] + acceptor + H2O. The enzyme requires ferredoxin. IEA GO:0045300 acyl-[acyl-carrier-protein] desaturase activity GSVIVG01023079001 15655687 15716372 GO:0006631 fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. IEA Catalysis of the reaction: stearoyl-[acyl-carrier protein] + reduced acceptor + O2 = oleoyl-[acyl-carrier protein] + acceptor + H2O. The enzyme requires ferredoxin. IEA GO:0045300 acyl-[acyl-carrier-protein] desaturase activity GSVIVG01023079001 15655687 15716372 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: stearoyl-[acyl-carrier protein] + reduced acceptor + O2 = oleoyl-[acyl-carrier protein] + acceptor + H2O. The enzyme requires ferredoxin. IEA GO:0045300 acyl-[acyl-carrier-protein] desaturase activity GSVIVG01023079001 15655687 15716372 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01023079001 15655687 15716372 GO:0006631 fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01023079001 15655687 15716372 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01037858001 7055780 7059118 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01010338001 19607086 19617233 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01010338001 19607086 19617233 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01010338001 19607086 19617233 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01010338001 19607086 19617233 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034739001 8796937 8798902 GSVIVG01022291001 18275634 18285205 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01022291001 18275634 18285205 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01022291001 18275634 18285205 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01022291001 18275634 18285205 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. IEA GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity GSVIVG01022291001 18275634 18285205 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. IEA GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity GSVIVG01022291001 18275634 18285205 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. IEA GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity GSVIVG01022291001 18275634 18285205 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022291001 18275634 18285205 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022291001 18275634 18285205 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022291001 18275634 18285205 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01022291001 18275634 18285205 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01022291001 18275634 18285205 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01011689001 5109752 5118063 GSVIVG01026269001 15216732 15223544 Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01026269001 15216732 15223544 Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01038269001 24829436 24843846 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01038269001 24829436 24843846 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01038269001 24829436 24843846 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025810001 11612540 11627834 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025810001 11612540 11627834 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the transfer of a segment of a (1,4)-alpha-D-glucan to a new 4-position in an acceptor, which may be glucose or (1,4)-alpha-D-glucan. IEA GO:0004134 4-alpha-glucanotransferase activity GSVIVG01025810001 11612540 11627834 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01025810001 11612540 11627834 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01006227001 23778774 23792563 GSVIVG01010290001 19097142 19129029 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA GSVIVG01012248001 220862 222178 GSVIVG01014285001 2307790 2308877 GSVIVG01000847001 2870317 2873190 GSVIVG01016493001 3432929 3433915 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016493001 3432929 3433915 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016493001 3432929 3433915 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016493001 3432929 3433915 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016493001 3432929 3433915 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01016493001 3432929 3433915 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01016493001 3432929 3433915 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016493001 3432929 3433915 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021355001 4380211 4382377 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01021355001 4380211 4382377 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01021355001 4380211 4382377 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01026962001 19001829 19004662 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026962001 19001829 19004662 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). IEA GO:0016769 transferase activity, transferring nitrogenous groups GSVIVG01026962001 19001829 19004662 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + methylthioadenosine. IEA GO:0016847 1-aminocyclopropane-1-carboxylate synthase activity GSVIVG01026962001 19001829 19004662 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01019809001 3511310 3512833 GSVIVG01023480001 11215093 11216857 GSVIVG01033364001 21197265 21200086 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01022056001 3603729 3615767 GO:0006750 glutathione biosynthetic process The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01022056001 3603729 3615767 GO:0006750 glutathione biosynthetic process The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins. IEA Catalysis of the reaction: ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione. IEA GO:0004363 glutathione synthase activity GSVIVG01022056001 3603729 3615767 GO:0006750 glutathione biosynthetic process The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022056001 3603729 3615767 GO:0006750 glutathione biosynthetic process The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01004906001 4699451 4704222 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01029147001 19186659 19204657 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01029147001 19186659 19204657 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01029147001 19186659 19204657 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01029147001 19186659 19204657 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013224001 6570701 6570874 GSVIVG01035659001 3084675 3087508 GSVIVG01022171001 17205712 17207076 GSVIVG01037614001 6246785 6252551 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GSVIVG01033639001 19026422 19057417 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01033639001 19026422 19057417 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01033639001 19026422 19057417 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. IEA GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity GSVIVG01033639001 19026422 19057417 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. IEA GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity GSVIVG01033639001 19026422 19057417 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033639001 19026422 19057417 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033639001 19026422 19057417 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01033639001 19026422 19057417 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01004873001 16252503 16257611 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01001694001 14382175 14384416 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01001694001 14382175 14384416 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001694001 14382175 14384416 Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01001694001 14382175 14384416 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01032042001 23262868 23264880 GSVIVG01011807001 3994677 4002209 GSVIVG01014793001 9794402 9814352 GSVIVG01037506001 12565679 12567676 GSVIVG01026825001 20161262 20163943 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01026825001 20161262 20163943 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01026825001 20161262 20163943 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026825001 20161262 20163943 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008585001 711458 716027 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01008585001 711458 716027 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01008585001 711458 716027 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01008585001 711458 716027 GO:0042254 ribosome biogenesis The process of the formation of the constituents of the ribosome subunits, their assembly, and their transport to the sites of protein synthesis. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01008585001 711458 716027 GO:0042254 ribosome biogenesis The process of the formation of the constituents of the ribosome subunits, their assembly, and their transport to the sites of protein synthesis. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01008585001 711458 716027 GO:0042254 ribosome biogenesis The process of the formation of the constituents of the ribosome subunits, their assembly, and their transport to the sites of protein synthesis. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01017660001 2429184 2432197 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01035968001 6608858 6616140 GO:0009416 response to light stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01035968001 6608858 6616140 GO:0009416 response to light stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029412001 16798527 16807245 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01029412001 16798527 16807245 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01028204001 4604939 4605913 GO:0009765 photosynthesis, light harvesting Absorption and transfer of the energy absorbed from light photons between photosystem reaction centers. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01008346001 3071407 3074093 GSVIVG01003332001 9125629 9128752 GSVIVG01028190001 4508261 4511517 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01028190001 4508261 4511517 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01028190001 4508261 4511517 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01028190001 4508261 4511517 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01028190001 4508261 4511517 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009395001 7981192 7983386 GSVIVG01036806001 22290729 22301684 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01010827001 23102730 23104466 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010827001 23102730 23104466 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001367001 24032518 24047833 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01001367001 24032518 24047833 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01013558001 20844845 20853619 GSVIVG01037129001 28815586 28819171 GSVIVG01000493001 14920741 14923863 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01000493001 14920741 14923863 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01000493001 14920741 14923863 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01000493001 14920741 14923863 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01016320001 5123656 5129109 GSVIVG01008257001 3997333 4001446 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA Catalysis of the reaction: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA. IEA GO:0004045 aminoacyl-tRNA hydrolase activity GSVIVG01006541001 43061855 43063064 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01014890001 11236194 11240828 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01014890001 11236194 11240828 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01014890001 11236194 11240828 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01014890001 11236194 11240828 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01004889001 16446708 16451164 GSVIVG01032972001 24722853 24732502 GSVIVG01035043001 1124496 1124822 GSVIVG01021523001 6601021 6607977 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01027054001 18328510 18339061 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01027054001 18328510 18339061 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01027054001 18328510 18339061 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028224001 4750474 4752712 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032537001 28160750 28169703 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01032537001 28160750 28169703 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01032537001 28160750 28169703 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01032537001 28160750 28169703 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01032537001 28160750 28169703 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. IEA GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity GSVIVG01032537001 28160750 28169703 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. IEA GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity GSVIVG01032537001 28160750 28169703 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. IEA GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity GSVIVG01032537001 28160750 28169703 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. IEA GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity GSVIVG01032537001 28160750 28169703 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01032537001 28160750 28169703 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01032537001 28160750 28169703 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01032537001 28160750 28169703 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01032537001 28160750 28169703 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032537001 28160750 28169703 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032537001 28160750 28169703 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032537001 28160750 28169703 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032537001 28160750 28169703 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032537001 28160750 28169703 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032537001 28160750 28169703 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032537001 28160750 28169703 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01005379001 39996371 39996759 GSVIVG01032721001 1263635 1266673 GSVIVG01031644001 19523280 19525079 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01029741001 13983639 13983922 GSVIVG01026058001 25170340 25173742 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01026058001 25170340 25173742 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01009993001 13208994 13210315 GSVIVG01009415001 8171671 8173596 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01009415001 8171671 8173596 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01009415001 8171671 8173596 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01009415001 8171671 8173596 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036102001 20694118 20697553 GSVIVG01027793001 7805373 7805981 GSVIVG01023713001 9866678 9879700 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023713001 9866678 9879700 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023713001 9866678 9879700 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01008368001 2798898 2800520 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01009203001 6214129 6218479 GSVIVG01009438001 8362081 8364108 GSVIVG01031326001 354953 356488 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031326001 354953 356488 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01035701001 3442165 3442402 GSVIVG01024131001 883689 883976 GSVIVG01009692001 10519590 10523508 GSVIVG01011412001 29446051 29447932 GSVIVG01032821001 494108 497196 GSVIVG01006299001 24731691 24739169 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01006299001 24731691 24739169 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01006299001 24731691 24739169 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01006299001 24731691 24739169 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01006299001 24731691 24739169 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003093001 8615125 8619113 GSVIVG01016317001 5166524 5167502 Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01020395001 20163017 20164139 GSVIVG01022304001 18367211 18374917 GO:0008219 cell death A biological process that results in permanent cessation of all vital functions of a cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01010028001 13614975 13618325 GO:0006631 fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01010028001 13614975 13618325 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01010028001 13614975 13618325 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01010028001 13614975 13618325 GO:0006631 fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. IEA Catalysis of the reaction: stearoyl-[acyl-carrier protein] + reduced acceptor + O2 = oleoyl-[acyl-carrier protein] + acceptor + H2O. The enzyme requires ferredoxin. IEA GO:0045300 acyl-[acyl-carrier-protein] desaturase activity GSVIVG01010028001 13614975 13618325 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Catalysis of the reaction: stearoyl-[acyl-carrier protein] + reduced acceptor + O2 = oleoyl-[acyl-carrier protein] + acceptor + H2O. The enzyme requires ferredoxin. IEA GO:0045300 acyl-[acyl-carrier-protein] desaturase activity GSVIVG01010028001 13614975 13618325 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: stearoyl-[acyl-carrier protein] + reduced acceptor + O2 = oleoyl-[acyl-carrier protein] + acceptor + H2O. The enzyme requires ferredoxin. IEA GO:0045300 acyl-[acyl-carrier-protein] desaturase activity GSVIVG01010028001 13614975 13618325 GO:0006631 fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01010028001 13614975 13618325 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01010028001 13614975 13618325 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01012435001 739070 742131 GSVIVG01004632001 39228708 39232641 GSVIVG01017491001 9385773 9386782 GSVIVG01021689001 9584913 9595211 GSVIVG01029088001 12315752 12321473 GSVIVG01007039001 29831767 29836557 GSVIVG01020012001 11599814 11601818 GSVIVG01024183001 524611 530365 GSVIVG01033335001 21385547 21390843 GSVIVG01000574001 6948087 6954828 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0005839 proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. IEA GO:0004175 endopeptidase activity GSVIVG01000574001 6948087 6954828 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0005839 proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. IEA Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. IEA GO:0004298 threonine-type endopeptidase activity GSVIVG01035905001 5625725 5635064 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01031777001 4282872 4285254 GSVIVG01013987001 8512945 8513406 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01013650001 1977231 1983424 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01013650001 1977231 1983424 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031725001 3852062 3854362 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01031725001 3852062 3854362 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01031725001 3852062 3854362 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01031725001 3852062 3854362 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01019651001 2206314 2212270 GO:0019028 viral capsid The protein coat that surrounds the infective nucleic acid in some virus particles. It comprises numerous regularly arranged subunits, or capsomeres. IEA Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion. IEA GO:0004091 carboxylesterase activity GSVIVG01019651001 2206314 2212270 GO:0019028 viral capsid The protein coat that surrounds the infective nucleic acid in some virus particles. It comprises numerous regularly arranged subunits, or capsomeres. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01010868001 16685543 16692303 GO:0032313 regulation of Rab GTPase activity Any process that modulates the activity of a GTPase of the Rab family. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Increases the rate of GTP hydrolysis by a GTPase of the Rab family. IEA GO:0005097 Rab GTPase activator activity GSVIVG01009541001 9187086 9188873 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA GSVIVG01009541001 9187086 9188873 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA GSVIVG01009541001 9187086 9188873 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GSVIVG01001590001 18120984 18122034 GSVIVG01004902001 4666524 4667903 GSVIVG01028125001 4015250 4025818 GSVIVG01027475001 16456107 16463972 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01000251001 20543878 20546350 GO:0006725 cellular aromatic compound metabolic process The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells. IEA Interacting selectively and non-covalently with ferrous iron, Fe(II). IEA GO:0008198 ferrous iron binding GSVIVG01000251001 20543878 20546350 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with ferrous iron, Fe(II). IEA GO:0008198 ferrous iron binding GSVIVG01000251001 20543878 20546350 GO:0006725 cellular aromatic compound metabolic process The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01000251001 20543878 20546350 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01000251001 20543878 20546350 GO:0006725 cellular aromatic compound metabolic process The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01000251001 20543878 20546350 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01000251001 20543878 20546350 GO:0006725 cellular aromatic compound metabolic process The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and molecular oxygen is incorporated into a donor. IEA GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen GSVIVG01000251001 20543878 20546350 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and molecular oxygen is incorporated into a donor. IEA GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen GSVIVG01020273001 22021511 22044521 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020273001 22021511 22044521 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020273001 22021511 22044521 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020273001 22021511 22044521 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025088001 4606339 4628863 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01025088001 4606339 4628863 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01025029001 5157489 5162602 GSVIVG01023166001 21751538 21756732 GSVIVG01028886001 17816895 17817823 GSVIVG01000054001 3116045 3116973 GSVIVG01021060001 14295823 14297895 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01021060001 14295823 14297895 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01027162001 17338366 17341476 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01003838001 20556943 20562291 GO:0006535 cysteine biosynthetic process from serine The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: acetyl-CoA + L-serine = CoA + O-acetyl-L-serine. IEA GO:0009001 serine O-acetyltransferase activity GSVIVG01003838001 20556943 20562291 GO:0006535 cysteine biosynthetic process from serine The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01006092001 41366145 41367647 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01010252001 18388463 18389993 GSVIVG01027560001 15572751 15574421 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01027560001 15572751 15574421 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01027560001 15572751 15574421 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01027560001 15572751 15574421 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01017995001 5339503 5347393 GSVIVG01035918001 5783788 5809616 GSVIVG01014385001 3279599 3284011 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01014385001 3279599 3284011 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0010181 FMN binding GSVIVG01014385001 3279599 3284011 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01017113001 4274061 4276326 GSVIVG01024613001 8408059 8410031 GO:0007010 cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01024613001 8408059 8410031 GO:0009082 branched chain family amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01024613001 8408059 8410031 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01024613001 8408059 8410031 GO:0007010 cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. IEA Catalysis of the reaction: (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+. IEA GO:0004455 ketol-acid reductoisomerase activity GSVIVG01024613001 8408059 8410031 GO:0009082 branched chain family amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. IEA Catalysis of the reaction: (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+. IEA GO:0004455 ketol-acid reductoisomerase activity GSVIVG01024613001 8408059 8410031 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+. IEA GO:0004455 ketol-acid reductoisomerase activity GSVIVG01024613001 8408059 8410031 GO:0007010 cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024613001 8408059 8410031 GO:0009082 branched chain family amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024613001 8408059 8410031 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024613001 8408059 8410031 GO:0007010 cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01024613001 8408059 8410031 GO:0009082 branched chain family amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01024613001 8408059 8410031 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01034046001 15598955 15602122 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01034046001 15598955 15602122 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA Catalysis of the hydrolysis of ester linkages within nucleic acids. IEA GO:0004518 nuclease activity GSVIVG01037602001 10083833 10084117 GSVIVG01033598001 19432643 19441041 GO:0007067 mitosis A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033598001 19432643 19441041 GO:0030261 chromosome condensation The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025739001 12363239 12399172 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005667 transcription factor complex A protein complex, distinct from RNA polymerase, that associates with DNA at promoters or at cis-acting regulatory sequences, by direct binding or by interaction with other DNA-binding polypeptides or complexes, and regulates transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01001832001 26178367 26179543 GSVIVG01000190001 16002500 16009833 Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01000190001 16002500 16009833 Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01000190001 16002500 16009833 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01000190001 16002500 16009833 Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01028252001 4953766 4958112 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028252001 4953766 4958112 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01013751001 7942711 7943176 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01015051001 717945 720923 GSVIVG01026939001 19224655 19232599 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033941001 16516475 16526527 GSVIVG01034886001 15923474 15926074 GSVIVG01029450001 22738827 22751612 GSVIVG01022288001 18230772 18231460 GSVIVG01032101001 22697957 22706910 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01032101001 22697957 22706910 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016602 CCAAT-binding factor complex A heteromeric transcription factor complex that binds to the CCAAT-box upstream of promoters; in Saccharomyces it activates the transcription of genes in response to growth in a nonfermentable carbon source; consists of four known subunits: HAP2, HAP3, HAP4 and HAP5. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01032101001 22697957 22706910 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01032101001 22697957 22706910 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016602 CCAAT-binding factor complex A heteromeric transcription factor complex that binds to the CCAAT-box upstream of promoters; in Saccharomyces it activates the transcription of genes in response to growth in a nonfermentable carbon source; consists of four known subunits: HAP2, HAP3, HAP4 and HAP5. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01016934001 2695940 2699927 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01016934001 2695940 2699927 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01016934001 2695940 2699927 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01016934001 2695940 2699927 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016934001 2695940 2699927 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034488001 20544979 20556621 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01004415001 38479413 38482833 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01036047001 21444946 21449414 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01036047001 21444946 21449414 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01036047001 21444946 21449414 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01036047001 21444946 21449414 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028344001 6356419 6379351 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA GSVIVG01001825001 26112948 26121333 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031868001 5003384 5004868 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01031868001 5003384 5004868 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01031868001 5003384 5004868 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01031868001 5003384 5004868 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01032192001 21697955 21703833 GSVIVG01001090001 22579761 22585456 GSVIVG01017638001 2195139 2199442 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+. IEA GO:0004148 dihydrolipoyl dehydrogenase activity GSVIVG01017638001 2195139 2199442 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+. IEA GO:0004148 dihydrolipoyl dehydrogenase activity GSVIVG01017638001 2195139 2199442 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+. IEA GO:0004148 dihydrolipoyl dehydrogenase activity GSVIVG01017638001 2195139 2199442 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+. IEA GO:0004148 dihydrolipoyl dehydrogenase activity GSVIVG01017638001 2195139 2199442 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+. IEA GO:0004148 dihydrolipoyl dehydrogenase activity GSVIVG01017638001 2195139 2199442 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+. IEA GO:0004148 dihydrolipoyl dehydrogenase activity GSVIVG01017638001 2195139 2199442 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+. IEA GO:0004148 dihydrolipoyl dehydrogenase activity GSVIVG01017638001 2195139 2199442 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+. IEA GO:0004148 dihydrolipoyl dehydrogenase activity GSVIVG01017638001 2195139 2199442 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor. IEA GO:0004368 glycerol-3-phosphate dehydrogenase activity GSVIVG01017638001 2195139 2199442 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor. IEA GO:0004368 glycerol-3-phosphate dehydrogenase activity GSVIVG01017638001 2195139 2199442 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor. IEA GO:0004368 glycerol-3-phosphate dehydrogenase activity GSVIVG01017638001 2195139 2199442 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor. IEA GO:0004368 glycerol-3-phosphate dehydrogenase activity GSVIVG01017638001 2195139 2199442 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor. IEA GO:0004368 glycerol-3-phosphate dehydrogenase activity GSVIVG01017638001 2195139 2199442 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor. IEA GO:0004368 glycerol-3-phosphate dehydrogenase activity GSVIVG01017638001 2195139 2199442 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor. IEA GO:0004368 glycerol-3-phosphate dehydrogenase activity GSVIVG01017638001 2195139 2199442 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor. IEA GO:0004368 glycerol-3-phosphate dehydrogenase activity GSVIVG01017638001 2195139 2199442 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01017638001 2195139 2199442 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01017638001 2195139 2199442 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01017638001 2195139 2199442 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01017638001 2195139 2199442 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01017638001 2195139 2199442 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01017638001 2195139 2199442 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01017638001 2195139 2199442 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01017638001 2195139 2199442 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01017638001 2195139 2199442 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01017638001 2195139 2199442 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01017638001 2195139 2199442 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01017638001 2195139 2199442 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01017638001 2195139 2199442 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01017638001 2195139 2199442 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01017638001 2195139 2199442 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01017638001 2195139 2199442 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01017638001 2195139 2199442 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01017638001 2195139 2199442 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01017638001 2195139 2199442 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01017638001 2195139 2199442 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01017638001 2195139 2199442 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01017638001 2195139 2199442 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01017638001 2195139 2199442 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01020223001 8867514 8886341 GSVIVG01003989001 26514315 26517086 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003989001 26514315 26517086 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003989001 26514315 26517086 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003989001 26514315 26517086 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003989001 26514315 26517086 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003989001 26514315 26517086 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003989001 26514315 26517086 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003989001 26514315 26517086 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003989001 26514315 26517086 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003989001 26514315 26517086 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003989001 26514315 26517086 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003989001 26514315 26517086 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003989001 26514315 26517086 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+. IEA GO:0004367 glycerol-3-phosphate dehydrogenase (NAD+) activity GSVIVG01003989001 26514315 26517086 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+. IEA GO:0004367 glycerol-3-phosphate dehydrogenase (NAD+) activity GSVIVG01003989001 26514315 26517086 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+. IEA GO:0004367 glycerol-3-phosphate dehydrogenase (NAD+) activity GSVIVG01003989001 26514315 26517086 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+. IEA GO:0004367 glycerol-3-phosphate dehydrogenase (NAD+) activity GSVIVG01003989001 26514315 26517086 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+. IEA GO:0004367 glycerol-3-phosphate dehydrogenase (NAD+) activity GSVIVG01003989001 26514315 26517086 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+. IEA GO:0004367 glycerol-3-phosphate dehydrogenase (NAD+) activity GSVIVG01003989001 26514315 26517086 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+. IEA GO:0004367 glycerol-3-phosphate dehydrogenase (NAD+) activity GSVIVG01003989001 26514315 26517086 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+. IEA GO:0004367 glycerol-3-phosphate dehydrogenase (NAD+) activity GSVIVG01003989001 26514315 26517086 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+. IEA GO:0004367 glycerol-3-phosphate dehydrogenase (NAD+) activity GSVIVG01003989001 26514315 26517086 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+. IEA GO:0004367 glycerol-3-phosphate dehydrogenase (NAD+) activity GSVIVG01003989001 26514315 26517086 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+. IEA GO:0004367 glycerol-3-phosphate dehydrogenase (NAD+) activity GSVIVG01003989001 26514315 26517086 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+. IEA GO:0004367 glycerol-3-phosphate dehydrogenase (NAD+) activity GSVIVG01003989001 26514315 26517086 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01003989001 26514315 26517086 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01003989001 26514315 26517086 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01003989001 26514315 26517086 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01003989001 26514315 26517086 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01003989001 26514315 26517086 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01003989001 26514315 26517086 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01003989001 26514315 26517086 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01003989001 26514315 26517086 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01003989001 26514315 26517086 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01003989001 26514315 26517086 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01003989001 26514315 26517086 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01003989001 26514315 26517086 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01003989001 26514315 26517086 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01003989001 26514315 26517086 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01003989001 26514315 26517086 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01003989001 26514315 26517086 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01003989001 26514315 26517086 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01003989001 26514315 26517086 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01003989001 26514315 26517086 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01003989001 26514315 26517086 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01003989001 26514315 26517086 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01003989001 26514315 26517086 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01003989001 26514315 26517086 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01003989001 26514315 26517086 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01003989001 26514315 26517086 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01003989001 26514315 26517086 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01003989001 26514315 26517086 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01003989001 26514315 26517086 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01003989001 26514315 26517086 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01003989001 26514315 26517086 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01003989001 26514315 26517086 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01003989001 26514315 26517086 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01003989001 26514315 26517086 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01003989001 26514315 26517086 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01003989001 26514315 26517086 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01003989001 26514315 26517086 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GSVIVG01003989001 26514315 26517086 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GSVIVG01003989001 26514315 26517086 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GSVIVG01003989001 26514315 26517086 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GSVIVG01003989001 26514315 26517086 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GSVIVG01003989001 26514315 26517086 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GSVIVG01003989001 26514315 26517086 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GSVIVG01003989001 26514315 26517086 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GSVIVG01003989001 26514315 26517086 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GSVIVG01003989001 26514315 26517086 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GSVIVG01003989001 26514315 26517086 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GSVIVG01003989001 26514315 26517086 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GSVIVG01003989001 26514315 26517086 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01003989001 26514315 26517086 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01003989001 26514315 26517086 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01003989001 26514315 26517086 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01003989001 26514315 26517086 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01003989001 26514315 26517086 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01003989001 26514315 26517086 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01003989001 26514315 26517086 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01003989001 26514315 26517086 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01003989001 26514315 26517086 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01003989001 26514315 26517086 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01003989001 26514315 26517086 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01003989001 26514315 26517086 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with an identical protein to form a homodimer. IEA GO:0042803 protein homodimerization activity GSVIVG01003989001 26514315 26517086 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with an identical protein to form a homodimer. IEA GO:0042803 protein homodimerization activity GSVIVG01003989001 26514315 26517086 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with an identical protein to form a homodimer. IEA GO:0042803 protein homodimerization activity GSVIVG01003989001 26514315 26517086 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with an identical protein to form a homodimer. IEA GO:0042803 protein homodimerization activity GSVIVG01003989001 26514315 26517086 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with an identical protein to form a homodimer. IEA GO:0042803 protein homodimerization activity GSVIVG01003989001 26514315 26517086 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with an identical protein to form a homodimer. IEA GO:0042803 protein homodimerization activity GSVIVG01003989001 26514315 26517086 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with an identical protein to form a homodimer. IEA GO:0042803 protein homodimerization activity GSVIVG01003989001 26514315 26517086 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with an identical protein to form a homodimer. IEA GO:0042803 protein homodimerization activity GSVIVG01003989001 26514315 26517086 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with an identical protein to form a homodimer. IEA GO:0042803 protein homodimerization activity GSVIVG01003989001 26514315 26517086 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with an identical protein to form a homodimer. IEA GO:0042803 protein homodimerization activity GSVIVG01003989001 26514315 26517086 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with an identical protein to form a homodimer. IEA GO:0042803 protein homodimerization activity GSVIVG01003989001 26514315 26517086 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with an identical protein to form a homodimer. IEA GO:0042803 protein homodimerization activity GSVIVG01003989001 26514315 26517086 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01003989001 26514315 26517086 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01003989001 26514315 26517086 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01003989001 26514315 26517086 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01003989001 26514315 26517086 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01003989001 26514315 26517086 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01003989001 26514315 26517086 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01003989001 26514315 26517086 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01003989001 26514315 26517086 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01003989001 26514315 26517086 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01003989001 26514315 26517086 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01003989001 26514315 26517086 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01003989001 26514315 26517086 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01003989001 26514315 26517086 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01003989001 26514315 26517086 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01003989001 26514315 26517086 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01003989001 26514315 26517086 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01003989001 26514315 26517086 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01003989001 26514315 26517086 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01003989001 26514315 26517086 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01003989001 26514315 26517086 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01003989001 26514315 26517086 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01003989001 26514315 26517086 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01003989001 26514315 26517086 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01035008001 854146 857902 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01035008001 854146 857902 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01029816001 15218193 15254459 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01029816001 15218193 15254459 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01029816001 15218193 15254459 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01029816001 15218193 15254459 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029816001 15218193 15254459 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006807001 28712133 28712711 GSVIVG01008545001 962148 964124 GSVIVG01033925001 16675006 16681479 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01033925001 16675006 16681479 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01010979001 2467919 2477478 GO:0006415 translational termination The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code). IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Involved in catalyzing the release of a nascent polypeptide chain from a ribosome. IEA GO:0003747 translation release factor activity GSVIVG01010979001 2467919 2477478 GO:0006415 translational termination The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code). IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA A translation release factor that is specific for one or more particular termination codons; acts at the ribosomal A-site and require polypeptidyl-tRNA at the P-site. IEA GO:0016149 translation release factor activity, codon specific GSVIVG01038093001 23451590 23454866 GSVIVG01007816001 8760311 8768301 GSVIVG01027472001 16470921 16473571 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019525001 1336359 1338192 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019525001 1336359 1338192 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. IEA GO:0004722 protein serine/threonine phosphatase activity GSVIVG01020695001 3054523 3059101 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020695001 3054523 3059101 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017187001 5146238 5168948 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01017187001 5146238 5168948 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017187001 5146238 5168948 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01017187001 5146238 5168948 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01024099001 1066258 1081084 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024099001 1066258 1081084 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036746001 23086959 23090029 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01036746001 23086959 23090029 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01023401001 12525263 12550997 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01002746001 36303262 36304379 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01002746001 36303262 36304379 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01002746001 36303262 36304379 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01002746001 36303262 36304379 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01002746001 36303262 36304379 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01002746001 36303262 36304379 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01002746001 36303262 36304379 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01002746001 36303262 36304379 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01001376001 24092486 24096128 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01017997001 5352211 5353807 GO:0006696 ergosterol biosynthetic process The chemical reactions and pathways resulting in the formation of ergosterol, (22E)-ergosta-5,7,22-trien-3-beta-ol, a sterol found in ergot, yeast and moulds. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of the reaction which results in unsaturation at C-7 in the B ring of sterols. IEA GO:0000247 C-8 sterol isomerase activity GSVIVG01001225001 1549790 1580093 GSVIVG01014384001 3277109 3279574 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01034049001 15578905 15581583 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01004932001 21612648 21615897 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Enables the directed movement of acyl groups into, out of, within or between cells. IEA GO:0000036 acyl carrier activity GSVIVG01004932001 21612648 21615897 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Interacting selectizely with phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate). IEA GO:0031177 phosphopantetheine binding GSVIVG01004932001 21612648 21615897 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. IEA GO:0048037 cofactor binding GSVIVG01028612001 10765211 10774962 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01028612001 10765211 10774962 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01028612001 10765211 10774962 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01021530001 6694303 6698753 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01021530001 6694303 6698753 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01021530001 6694303 6698753 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01021530001 6694303 6698753 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01021530001 6694303 6698753 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01021530001 6694303 6698753 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01021530001 6694303 6698753 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01021530001 6694303 6698753 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01021530001 6694303 6698753 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01024364001 1601585 1601779 GSVIVG01015478001 4037045 4041815 GO:0006820 anion transport The directed movement of anions, atoms or small molecules with a net negative charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA IEA GO:0005452 inorganic anion exchanger activity GSVIVG01015478001 4037045 4041815 GO:0006820 anion transport The directed movement of anions, atoms or small molecules with a net negative charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA IEA GO:0005452 inorganic anion exchanger activity GSVIVG01015478001 4037045 4041815 GO:0006820 anion transport The directed movement of anions, atoms or small molecules with a net negative charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA IEA GO:0015380 anion exchanger activity GSVIVG01015478001 4037045 4041815 GO:0006820 anion transport The directed movement of anions, atoms or small molecules with a net negative charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA IEA GO:0015380 anion exchanger activity GSVIVG01016316001 5171611 5176590 GSVIVG01022864001 18678238 18679938 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000395001 693698 696084 GSVIVG01016390001 4287630 4294708 GSVIVG01021573001 7241767 7243530 GO:0006519 cellular amino acid and derivative metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021573001 7241767 7243530 GO:0019752 carboxylic acid metabolic process The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021573001 7241767 7243530 GO:0006519 cellular amino acid and derivative metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells. IEA Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. IEA GO:0016831 carboxy-lyase activity GSVIVG01021573001 7241767 7243530 GO:0019752 carboxylic acid metabolic process The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). IEA Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. IEA GO:0016831 carboxy-lyase activity GSVIVG01021573001 7241767 7243530 GO:0006519 cellular amino acid and derivative metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01021573001 7241767 7243530 GO:0019752 carboxylic acid metabolic process The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01031830001 4754778 4756269 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01031830001 4754778 4756269 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01004831001 5504705 5507912 GSVIVG01036651001 19848807 19868052 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01036651001 19848807 19868052 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01036651001 19848807 19868052 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01036651001 19848807 19868052 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036651001 19848807 19868052 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036651001 19848807 19868052 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01020227001 8847246 8851245 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01020227001 8847246 8851245 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01009327001 7471549 7473041 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01009327001 7471549 7473041 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01010384001 20034283 20034705 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01014660001 8297133 8299782 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01014660001 8297133 8299782 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01014660001 8297133 8299782 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01014660001 8297133 8299782 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01014660001 8297133 8299782 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01014660001 8297133 8299782 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01014660001 8297133 8299782 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01014660001 8297133 8299782 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01014660001 8297133 8299782 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01014660001 8297133 8299782 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01014660001 8297133 8299782 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01014660001 8297133 8299782 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01014660001 8297133 8299782 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005267 potassium channel activity GSVIVG01014660001 8297133 8299782 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005267 potassium channel activity GSVIVG01014660001 8297133 8299782 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005267 potassium channel activity GSVIVG01014660001 8297133 8299782 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005267 potassium channel activity GSVIVG01014660001 8297133 8299782 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005267 potassium channel activity GSVIVG01014660001 8297133 8299782 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005267 potassium channel activity GSVIVG01014660001 8297133 8299782 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01014660001 8297133 8299782 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01014660001 8297133 8299782 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01014660001 8297133 8299782 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01014660001 8297133 8299782 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01014660001 8297133 8299782 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01011104001 1533338 1555466 GSVIVG01023916001 2508656 2513056 GSVIVG01037170001 28352060 28356404 GO:0006006 glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. IEA Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+. IEA GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity GSVIVG01037170001 28352060 28356404 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+. IEA GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity GSVIVG01037170001 28352060 28356404 GO:0006006 glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01037170001 28352060 28356404 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01026125001 24227998 24230642 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01026125001 24227998 24230642 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01026125001 24227998 24230642 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01026125001 24227998 24230642 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01026125001 24227998 24230642 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01004510001 38933048 38936540 GO:0009416 response to light stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01004510001 38933048 38936540 GO:0009416 response to light stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018535001 13711817 13712050 GSVIVG01024889001 6219501 6219953 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024889001 6219501 6219953 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024889001 6219501 6219953 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001966001 5864698 5871371 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01001966001 5864698 5871371 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01023023001 16762778 16770041 GSVIVG01027352001 15988198 15988488 GSVIVG01029069001 11800870 11810878 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01029069001 11800870 11810878 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01029069001 11800870 11810878 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01029069001 11800870 11810878 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01029069001 11800870 11810878 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01029069001 11800870 11810878 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01035294001 155644 160125 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01012356001 1241979 1242062 GSVIVG01019914001 4424613 4427223 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01018181001 13480801 13484017 GSVIVG01028552001 9655333 9655924 GSVIVG01035201001 10331278 10331778 GSVIVG01013425001 545163 551309 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01013425001 545163 551309 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01013425001 545163 551309 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01013425001 545163 551309 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01013425001 545163 551309 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01013425001 545163 551309 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01013425001 545163 551309 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01013425001 545163 551309 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01022180001 17243215 17247545 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01022180001 17243215 17247545 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01018261001 12339248 12340356 GSVIVG01016128001 19515483 19521544 GSVIVG01003499001 10780443 10781372 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01030596001 7040712 7041736 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01030596001 7040712 7041736 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01030596001 7040712 7041736 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01030596001 7040712 7041736 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01030541001 6599739 6602709 GSVIVG01008100001 5795171 5797168 GSVIVG01023584001 7646847 7648250 GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O. IEA GO:0004129 cytochrome-c oxidase activity GSVIVG01035952001 6390424 6401066 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid. IEA GO:0008378 galactosyltransferase activity GSVIVG01035952001 6390424 6401066 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid. IEA GO:0008378 galactosyltransferase activity GSVIVG01035952001 6390424 6401066 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid. IEA GO:0008378 galactosyltransferase activity GSVIVG01035952001 6390424 6401066 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01035952001 6390424 6401066 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01035952001 6390424 6401066 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01035952001 6390424 6401066 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01035952001 6390424 6401066 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01035952001 6390424 6401066 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01021032001 15017218 15020147 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01022408001 19763920 19765588 GSVIVG01010966001 2559654 2568989 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0031461 cullin-RING ubiquitin ligase complex Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity. IEA Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins. IEA GO:0031625 ubiquitin protein ligase binding GSVIVG01012098001 1508154 1513345 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012098001 1508154 1513345 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012098001 1508154 1513345 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012098001 1508154 1513345 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01002377001 34458054 34466198 GSVIVG01017152001 4740168 4749129 GSVIVG01024338001 1155005 1159362 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01028383001 6873625 6888273 GSVIVG01008258001 3969399 3996695 GO:0006891 intra-Golgi vesicle-mediated transport The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network). IEA GO:0030173 integral to Golgi membrane Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the Golgi complex membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA GSVIVG01017270001 6200037 6223496 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of a reaction that alters the configuration of one or more chiral centers in an amino acid. IEA GO:0016855 racemase and epimerase activity, acting on amino acids and derivatives GSVIVG01017270001 6200037 6223496 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a reaction that alters the configuration of one or more chiral centers in an amino acid. IEA GO:0016855 racemase and epimerase activity, acting on amino acids and derivatives GSVIVG01038467001 9774609 9789444 GSVIVG01001987001 6093124 6093480 GSVIVG01020411001 19894727 19903429 GSVIVG01000238001 20409585 20417391 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01000238001 20409585 20417391 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01000238001 20409585 20417391 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01000238001 20409585 20417391 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01000238001 20409585 20417391 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000238001 20409585 20417391 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022235001 17739420 17745441 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01022235001 17739420 17745441 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022235001 17739420 17745441 Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01022235001 17739420 17745441 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01001107001 22675676 22682448 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01001107001 22675676 22682448 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01033949001 16424080 16425146 GSVIVG01015707001 16128956 16130695 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015707001 16128956 16130695 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021255001 3051400 3052154 GSVIVG01033894001 16943488 16951884 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01033894001 16943488 16951884 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01014997001 277101 281112 GSVIVG01019589001 1794323 1801778 GSVIVG01033132001 8183365 8184920 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033132001 8183365 8184920 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033132001 8183365 8184920 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033132001 8183365 8184920 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033132001 8183365 8184920 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01033132001 8183365 8184920 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01008913001 3349227 3350728 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01008913001 3349227 3350728 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021593001 7694908 7733343 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01021593001 7694908 7733343 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01021593001 7694908 7733343 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01021593001 7694908 7733343 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021593001 7694908 7733343 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021593001 7694908 7733343 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021593001 7694908 7733343 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01021593001 7694908 7733343 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01021593001 7694908 7733343 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01021593001 7694908 7733343 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01021593001 7694908 7733343 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01021593001 7694908 7733343 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01021593001 7694908 7733343 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01021593001 7694908 7733343 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01021593001 7694908 7733343 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01027125001 17630763 17632057 GSVIVG01011244001 10033248 10034875 GSVIVG01007546001 12367010 12375117 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01029365001 15501812 15504523 Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01029365001 15501812 15504523 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01000252001 20552339 20557870 GSVIVG01017645001 2344272 2348279 GSVIVG01024319001 826922 835760 Catalysis of the reaction: ATP + shikimate = ADP + shikimate 3-phosphate. IEA GO:0004765 shikimate kinase activity GSVIVG01024319001 826922 835760 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025027001 5175715 5176228 GSVIVG01003597001 11103904 11129883 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA GSVIVG01009549001 9289407 9306119 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01009549001 9289407 9306119 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01009549001 9289407 9306119 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01009549001 9289407 9306119 GO:0016042 lipid catabolic process The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01009549001 9289407 9306119 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01009549001 9289407 9306119 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01009549001 9289407 9306119 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01009549001 9289407 9306119 GO:0016042 lipid catabolic process The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01024403001 2145985 2150605 GSVIVG01015307001 2543757 2547532 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01013121001 8020588 8023605 GO:0005992 trehalose biosynthetic process The chemical reactions and pathways resulting in the formation of trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030901001 18637793 18640981 GSVIVG01012423001 625579 628608 GSVIVG01011384001 29222977 29226477 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01011384001 29222977 29226477 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015935 small ribosomal subunit The smaller of the two subunits of a ribosome. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01011384001 29222977 29226477 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01011384001 29222977 29226477 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015935 small ribosomal subunit The smaller of the two subunits of a ribosome. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01011384001 29222977 29226477 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ribosomal RNA. IEA GO:0019843 rRNA binding GSVIVG01011384001 29222977 29226477 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015935 small ribosomal subunit The smaller of the two subunits of a ribosome. IEA Interacting selectively and non-covalently with ribosomal RNA. IEA GO:0019843 rRNA binding GSVIVG01016466001 3629809 3635301 GSVIVG01022144001 16930097 16934113 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033179 proton-transporting V-type ATPase, V0 domain A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01018788001 19827504 19834013 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01020069001 10829206 10842136 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01020069001 10829206 10842136 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the endohydrolysis of 1,4-alpha-D-glucosidic linkages in polysaccharides containing three or more 1,4-alpha-linked D-glucose units. IEA GO:0004556 alpha-amylase activity GSVIVG01020069001 10829206 10842136 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01020069001 10829206 10842136 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01014519001 4729362 4732605 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014519001 4729362 4732605 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014519001 4729362 4732605 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014519001 4729362 4732605 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031500001 17904724 17912382 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010800001 22724543 22745577 GSVIVG01028879001 17836935 17840142 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01028879001 17836935 17840142 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01028879001 17836935 17840142 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01028879001 17836935 17840142 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01013911001 6662431 6664034 GSVIVG01021791001 7336891 7389349 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01021791001 7336891 7389349 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01021791001 7336891 7389349 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021791001 7336891 7389349 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01027026001 18503370 18505424 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027026001 18503370 18505424 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01027026001 18503370 18505424 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01030431001 5504404 5508556 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030431001 5504404 5508556 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030431001 5504404 5508556 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01030431001 5504404 5508556 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01030431001 5504404 5508556 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01030431001 5504404 5508556 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01030431001 5504404 5508556 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01030431001 5504404 5508556 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01007052001 29900569 29903141 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. IEA GO:0016597 amino acid binding GSVIVG01032341001 15292426 15304390 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nucleotidyl group to a reactant. IEA GO:0016779 nucleotidyltransferase activity GSVIVG01029260001 17896116 17899721 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01029260001 17896116 17899721 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds. IEA GO:0015035 protein disulfide oxidoreductase activity GSVIVG01019513001 1239610 1240527 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01019513001 1239610 1240527 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01037773001 7730105 7732118 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01037773001 7730105 7732118 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01037773001 7730105 7732118 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01037773001 7730105 7732118 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032054001 23174276 23183484 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01032054001 23174276 23183484 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01032054001 23174276 23183484 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01032054001 23174276 23183484 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01032054001 23174276 23183484 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01032054001 23174276 23183484 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032054001 23174276 23183484 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032054001 23174276 23183484 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032054001 23174276 23183484 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032054001 23174276 23183484 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032054001 23174276 23183484 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01032054001 23174276 23183484 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01032054001 23174276 23183484 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01032054001 23174276 23183484 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01032054001 23174276 23183484 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01036613001 19242828 19242923 GSVIVG01037816001 7563890 7582110 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01037816001 7563890 7582110 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01037816001 7563890 7582110 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01037816001 7563890 7582110 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01037816001 7563890 7582110 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01037816001 7563890 7582110 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01037816001 7563890 7582110 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01037816001 7563890 7582110 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01037816001 7563890 7582110 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01037816001 7563890 7582110 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01037816001 7563890 7582110 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01037816001 7563890 7582110 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01037816001 7563890 7582110 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01037816001 7563890 7582110 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01037816001 7563890 7582110 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01037816001 7563890 7582110 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01033311001 21606529 21610267 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01033311001 21606529 21610267 GO:0006163 purine nucleotide metabolic process The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01033311001 21606529 21610267 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Catalysis of the reaction: ATP + GMP = ADP + GDP. IEA GO:0004385 guanylate kinase activity GSVIVG01033311001 21606529 21610267 GO:0006163 purine nucleotide metabolic process The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. IEA Catalysis of the reaction: ATP + GMP = ADP + GDP. IEA GO:0004385 guanylate kinase activity GSVIVG01033311001 21606529 21610267 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033311001 21606529 21610267 GO:0006163 purine nucleotide metabolic process The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033311001 21606529 21610267 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01033311001 21606529 21610267 GO:0006163 purine nucleotide metabolic process The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01033311001 21606529 21610267 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate. IEA GO:0019205 nucleobase, nucleoside, nucleotide kinase activity GSVIVG01033311001 21606529 21610267 GO:0006163 purine nucleotide metabolic process The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. IEA Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate. IEA GO:0019205 nucleobase, nucleoside, nucleotide kinase activity GSVIVG01033662001 18837818 18842431 GSVIVG01011281001 10493816 10494091 GSVIVG01014838001 10402252 10419777 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014838001 10402252 10419777 Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01009865001 11920498 11929437 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01009865001 11920498 11929437 GO:0009725 response to hormone stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01009865001 11920498 11929437 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01009865001 11920498 11929437 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01009865001 11920498 11929437 GO:0009725 response to hormone stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01009865001 11920498 11929437 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01017505001 9571415 9574431 GO:0009664 plant-type cell wall organization A process that results in the assembly and arrangement of constituent parts of the cellulose and pectin-containing cell wall, or in the disassembly of the cellulose and pectin-containing cell wall. This process is carried out at the cellular level. An example of this process is found in Arabidopsis thaliana. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA GSVIVG01017505001 9571415 9574431 GO:0019953 sexual reproduction The regular alternation, in the life cycle of haplontic, diplontic and diplohaplontic organisms, of meiosis and fertilization which provides for the production offspring. In diplontic organisms there is a life cycle in which the products of meiosis behave directly as gametes, fusing to form a zygote from which the diploid, or sexually reproductive polyploid, adult organism will develop. In diplohaplontic organisms a haploid phase (gametophyte) exists in the life cycle between meiosis and fertilization (e.g. higher plants, many algae and Fungi); the products of meiosis are spores that develop as haploid individuals from which haploid gametes develop to form a diploid zygote; diplohaplontic organisms show an alternation of haploid and diploid generations. In haplontic organisms meiosis occurs in the zygote, giving rise to four haploid cells (e.g. many algae and protozoa), only the zygote is diploid and this may form a resistant spore, tiding organisms over hard times. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA GSVIVG01018896001 18842894 18846586 GSVIVG01019680001 2417892 2422350 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: ADP-glucose + (1,4)-alpha-D-glucosyl(n) = ADP + (1,4)-alpha-D-glucosyl(n+1). IEA GO:0009011 starch synthase activity GSVIVG01019680001 2417892 2422350 GO:0009250 glucan biosynthetic process The chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues. IEA Catalysis of the reaction: ADP-glucose + (1,4)-alpha-D-glucosyl(n) = ADP + (1,4)-alpha-D-glucosyl(n+1). IEA GO:0009011 starch synthase activity GSVIVG01019869001 4035665 4081274 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019869001 4035665 4081274 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01020994001 15844802 15849126 GSVIVG01022017001 4260421 4278615 GSVIVG01012950001 14190489 14191260 GSVIVG01021437001 5345568 5357901 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01021437001 5345568 5357901 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01021437001 5345568 5357901 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01021437001 5345568 5357901 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01021437001 5345568 5357901 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01021437001 5345568 5357901 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01031967001 5790697 5798203 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with transfer RNA. IEA GO:0000049 tRNA binding GSVIVG01031967001 5790697 5798203 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with transfer RNA. IEA GO:0000049 tRNA binding GSVIVG01031967001 5790697 5798203 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with transfer RNA. IEA GO:0000049 tRNA binding GSVIVG01031967001 5790697 5798203 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01031967001 5790697 5798203 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01031967001 5790697 5798203 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01031967001 5790697 5798203 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01031967001 5790697 5798203 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01031967001 5790697 5798203 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01031967001 5790697 5798203 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe). IEA GO:0004826 phenylalanine-tRNA ligase activity GSVIVG01031967001 5790697 5798203 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe). IEA GO:0004826 phenylalanine-tRNA ligase activity GSVIVG01031967001 5790697 5798203 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe). IEA GO:0004826 phenylalanine-tRNA ligase activity GSVIVG01031967001 5790697 5798203 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031967001 5790697 5798203 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031967001 5790697 5798203 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007934001 7384486 7411694 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01007934001 7384486 7411694 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01007934001 7384486 7411694 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01011662001 5436775 5450762 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005643 nuclear pore Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined. IEA The action of a molecule that contributes to the structural integrity of the nuclear pore complex. IEA GO:0017056 structural constituent of nuclear pore GSVIVG01007791001 8987335 8987805 GSVIVG01030475001 5982071 5989606 GO:0000278 mitotic cell cycle Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01030475001 5982071 5989606 GO:0007067 mitosis A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01017662001 2439089 2450560 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01017662001 2439089 2450560 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01017662001 2439089 2450560 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023530001 10185833 10207561 Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01037594001 10229159 10230489 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar. IEA GO:0008375 acetylglucosaminyltransferase activity GSVIVG01011776001 4259394 4264674 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01011776001 4259394 4264674 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01011776001 4259394 4264674 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01030582001 6888151 6890313 GSVIVG01013005001 10269857 10276842 GSVIVG01031306001 507334 512252 GO:0009987 cellular process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. IEA GSVIVG01021676001 9188437 9190051 GSVIVG01037095001 29194471 29198645 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01037095001 29194471 29198645 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01033781001 17877282 17880048 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01033781001 17877282 17880048 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01021629001 8401918 8403525 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021629001 8401918 8403525 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021629001 8401918 8403525 Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01025407001 1018174 1023111 GO:0006506 GPI anchor biosynthetic process The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol moiety is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate moiety, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage. IEA GO:0005789 endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01025407001 1018174 1023111 GO:0006506 GPI anchor biosynthetic process The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol moiety is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate moiety, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01024576001 8682504 8684735 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01024576001 8682504 8684735 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01000350001 11884521 11885474 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01000350001 11884521 11885474 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022470001 3451586 3469821 GO:0032259 methylation The process by which a methyl group is covalently attached to a molecule. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01022470001 3451586 3469821 GO:0032259 methylation The process by which a methyl group is covalently attached to a molecule. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01005098001 18072221 18073960 GSVIVG01010271001 18657363 18658552 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01010271001 18657363 18658552 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01010271001 18657363 18658552 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01010271001 18657363 18658552 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01002244001 33590035 33599364 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01015582001 5210791 5215642 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01015582001 5210791 5215642 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01015582001 5210791 5215642 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01015582001 5210791 5215642 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01005962001 22987441 22987904 GSVIVG01020098001 10374779 10375180 GSVIVG01003591001 11007438 11010998 GSVIVG01030294001 9345848 9346871 GO:0006826 iron ion transport The directed movement of iron (Fe) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01030294001 9345848 9346871 GO:0006879 cellular iron ion homeostasis Any process involved in the maintenance of an internal steady-state of iron ions at the level of a cell. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01030294001 9345848 9346871 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01030294001 9345848 9346871 GO:0006826 iron ion transport The directed movement of iron (Fe) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with ferric iron, Fe(III). IEA GO:0008199 ferric iron binding GSVIVG01030294001 9345848 9346871 GO:0006879 cellular iron ion homeostasis Any process involved in the maintenance of an internal steady-state of iron ions at the level of a cell. IEA Interacting selectively and non-covalently with ferric iron, Fe(III). IEA GO:0008199 ferric iron binding GSVIVG01030294001 9345848 9346871 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with ferric iron, Fe(III). IEA GO:0008199 ferric iron binding GSVIVG01030294001 9345848 9346871 GO:0006826 iron ion transport The directed movement of iron (Fe) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01030294001 9345848 9346871 GO:0006879 cellular iron ion homeostasis Any process involved in the maintenance of an internal steady-state of iron ions at the level of a cell. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01030294001 9345848 9346871 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01030294001 9345848 9346871 GO:0006826 iron ion transport The directed movement of iron (Fe) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01030294001 9345848 9346871 GO:0006879 cellular iron ion homeostasis Any process involved in the maintenance of an internal steady-state of iron ions at the level of a cell. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01030294001 9345848 9346871 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01027237001 17793660 17806240 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027237001 17793660 17806240 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027237001 17793660 17806240 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027237001 17793660 17806240 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027237001 17793660 17806240 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01027237001 17793660 17806240 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01027237001 17793660 17806240 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01027237001 17793660 17806240 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01008414001 2319875 2321429 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). IEA GO:0003755 peptidyl-prolyl cis-trans isomerase activity GSVIVG01008414001 2319875 2321429 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). IEA GO:0003755 peptidyl-prolyl cis-trans isomerase activity GSVIVG01008414001 2319875 2321429 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). IEA GO:0003755 peptidyl-prolyl cis-trans isomerase activity GSVIVG01008414001 2319875 2321429 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). IEA GO:0003755 peptidyl-prolyl cis-trans isomerase activity GSVIVG01008414001 2319875 2321429 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. IEA GO:0004969 histamine receptor activity GSVIVG01008414001 2319875 2321429 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. IEA GO:0004969 histamine receptor activity GSVIVG01008414001 2319875 2321429 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. IEA GO:0004969 histamine receptor activity GSVIVG01008414001 2319875 2321429 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. IEA GO:0004969 histamine receptor activity GSVIVG01008414001 2319875 2321429 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. IEA GO:0005179 hormone activity GSVIVG01008414001 2319875 2321429 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. IEA GO:0005179 hormone activity GSVIVG01008414001 2319875 2321429 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. IEA GO:0005179 hormone activity GSVIVG01008414001 2319875 2321429 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. IEA GO:0005179 hormone activity GSVIVG01008414001 2319875 2321429 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. IEA GO:0016853 isomerase activity GSVIVG01008414001 2319875 2321429 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. IEA GO:0016853 isomerase activity GSVIVG01008414001 2319875 2321429 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. IEA GO:0016853 isomerase activity GSVIVG01008414001 2319875 2321429 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. IEA GO:0016853 isomerase activity GSVIVG01010164001 16618594 16619285 GSVIVG01005972001 23041967 23053334 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01005972001 23041967 23053334 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01016681001 339621 343123 GSVIVG01001478001 12078526 12099536 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01001478001 12078526 12099536 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01001478001 12078526 12099536 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01026879001 19687801 19689218 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01001687001 14276150 14276380 GSVIVG01032410001 27092982 27104698 GSVIVG01010849001 23330064 23338852 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01010849001 23330064 23338852 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01027931001 9637019 9715468 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01027931001 9637019 9715468 GO:0006298 mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01027931001 9637019 9715468 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027931001 9637019 9715468 GO:0006298 mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027931001 9637019 9715468 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids. IEA GO:0004518 nuclease activity GSVIVG01027931001 9637019 9715468 GO:0006298 mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids. IEA GO:0004518 nuclease activity GSVIVG01027931001 9637019 9715468 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027931001 9637019 9715468 GO:0006298 mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027931001 9637019 9715468 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01027931001 9637019 9715468 GO:0006298 mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01027931001 9637019 9715468 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches. IEA GO:0030983 mismatched DNA binding GSVIVG01027931001 9637019 9715468 GO:0006298 mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches. IEA GO:0030983 mismatched DNA binding GSVIVG01000440001 8048579 8050084 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01011599001 6083422 6086124 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01001187001 1004538 1012099 GSVIVG01000457001 8176667 8181275 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other. IEA GO:0005337 nucleoside transmembrane transporter activity GSVIVG01008087001 5873877 5894748 GSVIVG01020575001 4173532 4177079 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01020575001 4173532 4177079 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01020575001 4173532 4177079 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01020575001 4173532 4177079 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01020575001 4173532 4177079 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01020575001 4173532 4177079 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01020575001 4173532 4177079 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01020575001 4173532 4177079 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028002001 3117581 3119881 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028002001 3117581 3119881 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01028002001 3117581 3119881 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01016667001 241390 248247 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01016667001 241390 248247 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the reaction: pectin + n H2O = n methanol + pectate. IEA GO:0030599 pectinesterase activity GSVIVG01016667001 241390 248247 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue. IEA GO:0045330 aspartyl esterase activity GSVIVG01024468001 3024071 3046441 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01024468001 3024071 3046441 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01020052001 11042154 11042492 GSVIVG01031272001 661120 665399 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031272001 661120 665399 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031272001 661120 665399 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031272001 661120 665399 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031272001 661120 665399 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01031272001 661120 665399 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01022896001 18197283 18197907 Functions in the storage of nutritious substrates. IEA GO:0045735 nutrient reservoir activity GSVIVG01035838001 4778510 4779248 GSVIVG01000817001 531532 553099 GO:0006099 tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. IEA Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor), with the acyl group being converted into alkyl on transfer. IEA GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer GSVIVG01000817001 531532 553099 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor), with the acyl group being converted into alkyl on transfer. IEA GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer GSVIVG01019555001 1579135 1583057 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01003319001 9004118 9005348 GSVIVG01019895001 4307378 4323174 GSVIVG01010334001 19576383 19577202 GSVIVG01017872001 4194129 4204982 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020786001 1992495 2002600 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01020786001 1992495 2002600 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01020786001 1992495 2002600 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01020786001 1992495 2002600 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020786001 1992495 2002600 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014445001 3850729 3854891 The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01034523001 19897547 19900584 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019565001 1643880 1646665 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019565001 1643880 1646665 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019565001 1643880 1646665 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019565001 1643880 1646665 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01019565001 1643880 1646665 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01019565001 1643880 1646665 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01020806001 1739677 1742834 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01020806001 1739677 1742834 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01020806001 1739677 1742834 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01020806001 1739677 1742834 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01032149001 22103974 22108642 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032149001 22103974 22108642 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01032149001 22103974 22108642 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01007130001 30276620 30281096 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01007130001 30276620 30281096 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01007130001 30276620 30281096 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01007130001 30276620 30281096 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01007130001 30276620 30281096 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01007130001 30276620 30281096 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01006269001 24370759 24373006 GSVIVG01023895001 2613671 2617041 GSVIVG01000129001 15505890 15506937 GSVIVG01015234001 2008616 2012798 GSVIVG01000009001 2656366 2692593 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000009001 2656366 2692593 GO:0009081 branched chain family amino acid metabolic process The chemical reactions and pathways involving amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000009001 2656366 2692593 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: a branched-chain amino acid + 2-oxoglutarate = L-glutamate + a 2-oxocarboxylate derived from the branched-chain amino acid. Includes catalysis of the reaction: L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate and anaologous reactions involving L-isoleucine and L-valine. IEA GO:0004084 branched-chain-amino-acid transaminase activity GSVIVG01000009001 2656366 2692593 GO:0009081 branched chain family amino acid metabolic process The chemical reactions and pathways involving amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. IEA Catalysis of the reaction: a branched-chain amino acid + 2-oxoglutarate = L-glutamate + a 2-oxocarboxylate derived from the branched-chain amino acid. Includes catalysis of the reaction: L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate and anaologous reactions involving L-isoleucine and L-valine. IEA GO:0004084 branched-chain-amino-acid transaminase activity GSVIVG01037327001 15634630 15656310 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01037327001 15634630 15656310 Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. IEA GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GSVIVG01014555001 5085859 5089101 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01014555001 5085859 5089101 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01015269001 2279741 2283628 Catalysis of the reaction: (5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl-amino acid. IEA GO:0003840 gamma-glutamyltransferase activity GSVIVG01038391001 11641099 11643369 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01038391001 11641099 11643369 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01038391001 11641099 11643369 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01038391001 11641099 11643369 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01038391001 11641099 11643369 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01038391001 11641099 11643369 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01038391001 11641099 11643369 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01038391001 11641099 11643369 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01038391001 11641099 11643369 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01038391001 11641099 11643369 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01038391001 11641099 11643369 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01038391001 11641099 11643369 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01038391001 11641099 11643369 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038391001 11641099 11643369 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038391001 11641099 11643369 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038391001 11641099 11643369 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01038391001 11641099 11643369 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01038391001 11641099 11643369 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01030558001 6726706 6729599 GSVIVG01032296001 14650796 14737520 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032296001 14650796 14737520 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032296001 14650796 14737520 GO:0006397 mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032296001 14650796 14737520 GO:0006397 mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01020604001 3879374 3882657 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01038215001 24426844 24427077 GSVIVG01015745001 16773258 16775286 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01008193001 4802273 4803138 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: 3-alpha(S)-strictosidine = tryptamine + secologanin. IEA GO:0016844 strictosidine synthase activity GSVIVG01009936001 12579080 12591899 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01009936001 12579080 12591899 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01009936001 12579080 12591899 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01037191001 28161873 28162865 GSVIVG01016554001 2847204 2848859 GSVIVG01037155001 28516117 28528636 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032507001 27976694 27978618 GSVIVG01002005001 6208064 6214320 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01002005001 6208064 6214320 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01002005001 6208064 6214320 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01002005001 6208064 6214320 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01002005001 6208064 6214320 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01002005001 6208064 6214320 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01002005001 6208064 6214320 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01002005001 6208064 6214320 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008635001 248579 249243 GSVIVG01018899001 18815168 18816492 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01020236001 8704047 8710652 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01004486001 38835755 38840548 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01036634001 19514539 19517599 GSVIVG01011498001 30050666 30053512 GSVIVG01016616001 2421436 2425106 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009654 oxygen evolving complex A complex, composed of a cluster of manganese, calcium and chloride ions bound to extrinsic proteins, that catalyzes the splitting of water to O2 and 4 H+. In cyanobacteria there are five extrinsic proteins in OEC (PsbO, PsbP-like, PsbQ-like, PsbU and PsbV), while in plants there are only three (PsbO, PsbP and PsbQ). IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01016616001 2421436 2425106 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0019898 extrinsic to membrane Loosely bound to one surface of a membrane, but not integrated into the hydrophobic region. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01007536001 12527468 12530386 GSVIVG01012039001 1929406 1932533 GSVIVG01002948001 37317890 37318763 GSVIVG01015286001 2391730 2407025 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01015286001 2391730 2407025 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01015286001 2391730 2407025 GO:0006420 arginyl-tRNA aminoacylation The process of coupling arginine to arginyl-tRNA, catalyzed by arginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01015286001 2391730 2407025 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01015286001 2391730 2407025 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01015286001 2391730 2407025 GO:0006420 arginyl-tRNA aminoacylation The process of coupling arginine to arginyl-tRNA, catalyzed by arginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01015286001 2391730 2407025 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). IEA GO:0004814 arginine-tRNA ligase activity GSVIVG01015286001 2391730 2407025 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). IEA GO:0004814 arginine-tRNA ligase activity GSVIVG01015286001 2391730 2407025 GO:0006420 arginyl-tRNA aminoacylation The process of coupling arginine to arginyl-tRNA, catalyzed by arginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). IEA GO:0004814 arginine-tRNA ligase activity GSVIVG01015286001 2391730 2407025 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015286001 2391730 2407025 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015286001 2391730 2407025 GO:0006420 arginyl-tRNA aminoacylation The process of coupling arginine to arginyl-tRNA, catalyzed by arginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013167001 7296723 7304697 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013167001 7296723 7304697 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013167001 7296723 7304697 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008237 metallopeptidase activity GSVIVG01013167001 7296723 7304697 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008237 metallopeptidase activity GSVIVG01013167001 7296723 7304697 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01013167001 7296723 7304697 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01013167001 7296723 7304697 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01013167001 7296723 7304697 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01021463001 5673056 5675288 GSVIVG01025009001 5316225 5323608 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025009001 5316225 5323608 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01017401001 7959444 7960698 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01017401001 7959444 7960698 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01034486001 20571197 20583726 GSVIVG01011351001 28889659 28894751 GSVIVG01001996001 6153028 6157170 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01008904001 3282681 3291682 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01008904001 3282681 3291682 Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA. IEA GO:0004540 ribonuclease activity GSVIVG01034244001 13409049 13414664 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01034244001 13409049 13414664 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01034244001 13409049 13414664 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01034244001 13409049 13414664 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01034244001 13409049 13414664 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01034244001 13409049 13414664 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01034244001 13409049 13414664 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01034244001 13409049 13414664 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01034244001 13409049 13414664 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01031980001 5885527 5887512 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015642001 14771549 14773578 GSVIVG01013204001 6747213 6761452 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01013204001 6747213 6761452 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01013204001 6747213 6761452 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01029822001 35950 46343 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01025369001 1409805 1411489 GSVIVG01000707001 15949808 15951051 GSVIVG01009893001 12194087 12200260 GSVIVG01003532001 85634 86040 GSVIVG01009042001 4491992 4494498 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin. IEA GO:0004221 ubiquitin thiolesterase activity GSVIVG01003370001 9474456 9475112 GSVIVG01015882001 18921815 18923535 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01015882001 18921815 18923535 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01035806001 4535504 4538070 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01025419001 957069 959216 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01025419001 957069 959216 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025419001 957069 959216 Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01022206001 17461574 17461776 GSVIVG01017337001 6856676 6857829 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01000310001 2881203 2882126 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01000310001 2881203 2882126 Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium. IEA GO:0005544 calcium-dependent phospholipid binding GSVIVG01009244001 6580897 6634655 GSVIVG01026164001 13266843 13266962 GSVIVG01016767001 1167732 1176015 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01007217001 30928716 30930448 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GSVIVG01013560001 20881430 20884073 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01013560001 20881430 20884073 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01003637001 11388264 11388419 GSVIVG01027546001 15859795 15863065 GSVIVG01015601001 5463360 5477250 GSVIVG01021438001 5361306 5361599 GSVIVG01024741001 7301238 7304370 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01024741001 7301238 7304370 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01024741001 7301238 7304370 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01024741001 7301238 7304370 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01024741001 7301238 7304370 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01024741001 7301238 7304370 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01024741001 7301238 7304370 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01024741001 7301238 7304370 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01034297001 14324218 14325002 GSVIVG01007868001 8166163 8174076 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01007868001 8166163 8174076 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01006335001 269544 273954 GSVIVG01025663001 13111821 13118430 GSVIVG01011789001 4133090 4137759 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01007270001 1185582 1187952 GO:0016311 dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. IEA Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. IEA GO:0004725 protein tyrosine phosphatase activity GSVIVG01007270001 1185582 1187952 GO:0016311 dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. IEA Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. IEA GO:0016791 phosphatase activity GSVIVG01030186001 10722215 10725214 GSVIVG01013483001 1545055 1549032 GO:0046488 phosphatidylinositol metabolic process The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. IEA Catalysis of the phosphorylation of phosphatidylinositol phosphate to produce phosphatidylinositol bisphosphate. IEA GO:0016307 phosphatidylinositol phosphate kinase activity GSVIVG01000244001 20473817 20479266 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01000244001 20473817 20479266 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01000244001 20473817 20479266 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01021389001 4807223 4823398 GSVIVG01017303001 6522435 6523811 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01014025001 9174932 9178607 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01014025001 9174932 9178607 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01014025001 9174932 9178607 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01014025001 9174932 9178607 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01033461001 20499878 20507104 GSVIVG01001995001 6147033 6148871 GSVIVG01012209001 550211 556153 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01012209001 550211 556153 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01013755001 7930544 7932916 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage. IEA GO:0016209 antioxidant activity GSVIVG01013755001 7930544 7932916 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01015328001 2736062 2743325 GSVIVG01024068001 1383646 1391290 Catalysis of the transfer of the amide nitrogen of glutamine to a variety of substrates. GATases catalyze two separate reactions at two active sites, which are located either on a single polypeptide chain or on different subunits. In the glutaminase reaction, glutamine is hydrolyzed to glutamate and ammonia, which is added to an acceptor substrate in the synthase reaction. IEA GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor GSVIVG01024463001 2941201 2943159 GSVIVG01028954001 17127264 17127530 GSVIVG01004461001 38687951 38688133 GSVIVG01037402001 14328498 14351031 GSVIVG01013851001 5207501 5222413 GSVIVG01018379001 10052958 10058708 GSVIVG01023279001 20190857 20199319 GO:0005923 tight junction An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01022411001 19842574 19845214 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01022411001 19842574 19845214 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01011442001 29688433 29692203 GSVIVG01001924001 14850245 14850575 GSVIVG01023721001 10047356 10093618 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01038281001 24946235 24947803 GSVIVG01009453001 8514131 8515605 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01009453001 8514131 8515605 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01009453001 8514131 8515605 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01009453001 8514131 8515605 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01009453001 8514131 8515605 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01009453001 8514131 8515605 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01022086001 16478586 16480603 GSVIVG01009221001 6387734 6394700 GSVIVG01020179001 9369141 9379711 GSVIVG01021809001 7094928 7100966 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021809001 7094928 7100966 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021809001 7094928 7100966 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01003675001 12018937 12021447 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01014270001 2195915 2203758 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01028335001 6254524 6266907 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005744 mitochondrial inner membrane presequence translocase complex The protein transport machinery of the mitochondrial inner membrane that contains three essential Tim proteins: Tim17 and Tim23 are thought to build a preprotein translocation channel while Tim44 interacts transiently with the matrix heat-shock protein Hsp70 to form an ATP-driven import motor. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01015037001 646508 647791 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01015037001 646508 647791 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01009729001 10831633 10837616 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the reaction: pectin + n H2O = n methanol + pectate. IEA GO:0030599 pectinesterase activity GSVIVG01031709001 3610208 3626250 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01031709001 3610208 3626250 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01031709001 3610208 3626250 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01003608001 11210005 11214097 Interacting selectively and non-covalently with a specific domain of a protein. IEA GO:0019904 protein domain specific binding GSVIVG01008309001 3396901 3402903 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01008309001 3396901 3402903 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01008309001 3396901 3402903 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01008309001 3396901 3402903 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016284001 5551820 5553973 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01010339001 19617239 19617692 GSVIVG01029880001 902362 904749 Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum. IEA GO:0003993 acid phosphatase activity GSVIVG01029487001 22352356 22353917 GSVIVG01019902001 4357335 4364368 GO:0006801 superoxide metabolic process The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01019902001 4357335 4364368 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01019902001 4357335 4364368 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01030430001 5491822 5495385 GSVIVG01031128001 1892425 1897786 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01031128001 1892425 1897786 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01031128001 1892425 1897786 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01031128001 1892425 1897786 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01031128001 1892425 1897786 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01031128001 1892425 1897786 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01031128001 1892425 1897786 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01031128001 1892425 1897786 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01031128001 1892425 1897786 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031128001 1892425 1897786 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031128001 1892425 1897786 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01031128001 1892425 1897786 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01031128001 1892425 1897786 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces an oxygen molecule. IEA GO:0050664 oxidoreductase activity, acting on NADH or NADPH, with oxygen as acceptor GSVIVG01031128001 1892425 1897786 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces an oxygen molecule. IEA GO:0050664 oxidoreductase activity, acting on NADH or NADPH, with oxygen as acceptor GSVIVG01009855001 11804382 11833989 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01009855001 11804382 11833989 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01009855001 11804382 11833989 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01009855001 11804382 11833989 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01018789001 19822102 19827502 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01021485001 6053011 6057369 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018983001 18095521 18100098 GSVIVG01032777001 824557 834472 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a nucleotidyl group to a reactant. IEA GO:0016779 nucleotidyltransferase activity GSVIVG01037731001 7323009 7328503 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01007538001 12501668 12507105 GSVIVG01021894001 5971007 5973383 GSVIVG01017745001 3086199 3099862 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01017745001 3086199 3099862 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01017745001 3086199 3099862 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01017745001 3086199 3099862 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01017745001 3086199 3099862 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01017745001 3086199 3099862 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01017745001 3086199 3099862 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01017745001 3086199 3099862 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01017745001 3086199 3099862 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01017745001 3086199 3099862 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017745001 3086199 3099862 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017745001 3086199 3099862 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017745001 3086199 3099862 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017745001 3086199 3099862 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017745001 3086199 3099862 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017745001 3086199 3099862 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017745001 3086199 3099862 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017745001 3086199 3099862 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01022148001 16974743 16982996 GSVIVG01022310001 18405754 18406721 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01028069001 3581269 3584264 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01028069001 3581269 3584264 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01028069001 3581269 3584264 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01028069001 3581269 3584264 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01028069001 3581269 3584264 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01028069001 3581269 3584264 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01029982001 2693274 2694429 GSVIVG01022482001 3635397 3638544 GSVIVG01034662001 12931781 12943147 GSVIVG01036406001 4696768 4705486 GSVIVG01032461001 27646939 27657107 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01032461001 27646939 27657107 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01032461001 27646939 27657107 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01032461001 27646939 27657107 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023557001 9703856 9710052 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023557001 9703856 9710052 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023557001 9703856 9710052 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023557001 9703856 9710052 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023557001 9703856 9710052 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023557001 9703856 9710052 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023557001 9703856 9710052 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01023557001 9703856 9710052 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01023557001 9703856 9710052 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01023557001 9703856 9710052 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01023557001 9703856 9710052 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01023557001 9703856 9710052 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01023557001 9703856 9710052 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023557001 9703856 9710052 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023557001 9703856 9710052 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023557001 9703856 9710052 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023557001 9703856 9710052 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023557001 9703856 9710052 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023557001 9703856 9710052 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01023557001 9703856 9710052 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01023557001 9703856 9710052 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01023557001 9703856 9710052 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01023557001 9703856 9710052 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01023557001 9703856 9710052 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01026229001 14481689 14483512 GO:0009086 methionine biosynthetic process The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. IEA Catalysis of the reaction: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine. IEA GO:0003871 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity GSVIVG01024243001 153316 156961 GSVIVG01037490001 12798997 12803615 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01037490001 12798997 12803615 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01037490001 12798997 12803615 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01037490001 12798997 12803615 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01037490001 12798997 12803615 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01022029001 4110264 4147204 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01020832001 1434239 1435842 Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01032024001 23445861 23452944 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032024001 23445861 23452944 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01032024001 23445861 23452944 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01024716001 7499157 7510233 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01024716001 7499157 7510233 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. IEA GO:0008080 N-acetyltransferase activity GSVIVG01024716001 7499157 7510233 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01000883001 3424932 3438391 GSVIVG01013471001 159414 165445 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013471001 159414 165445 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01016878001 2187509 2193420 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01016878001 2187509 2193420 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01016878001 2187509 2193420 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01016878001 2187509 2193420 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028215001 4682950 4684167 GO:0009664 plant-type cell wall organization A process that results in the assembly and arrangement of constituent parts of the cellulose and pectin-containing cell wall, or in the disassembly of the cellulose and pectin-containing cell wall. This process is carried out at the cellular level. An example of this process is found in Arabidopsis thaliana. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA GSVIVG01028215001 4682950 4684167 GO:0019953 sexual reproduction The regular alternation, in the life cycle of haplontic, diplontic and diplohaplontic organisms, of meiosis and fertilization which provides for the production offspring. In diplontic organisms there is a life cycle in which the products of meiosis behave directly as gametes, fusing to form a zygote from which the diploid, or sexually reproductive polyploid, adult organism will develop. In diplohaplontic organisms a haploid phase (gametophyte) exists in the life cycle between meiosis and fertilization (e.g. higher plants, many algae and Fungi); the products of meiosis are spores that develop as haploid individuals from which haploid gametes develop to form a diploid zygote; diplohaplontic organisms show an alternation of haploid and diploid generations. In haplontic organisms meiosis occurs in the zygote, giving rise to four haploid cells (e.g. many algae and protozoa), only the zygote is diploid and this may form a resistant spore, tiding organisms over hard times. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA GSVIVG01000579001 6886457 6888175 GSVIVG01003563001 14675185 14682521 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01003563001 14675185 14682521 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01003563001 14675185 14682521 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01003563001 14675185 14682521 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01003563001 14675185 14682521 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003563001 14675185 14682521 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003563001 14675185 14682521 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01003563001 14675185 14682521 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01036703001 23555077 23625967 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01036703001 23555077 23625967 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01036703001 23555077 23625967 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036703001 23555077 23625967 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036703001 23555077 23625967 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01022823001 19038288 19052599 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01022823001 19038288 19052599 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01022823001 19038288 19052599 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01022823001 19038288 19052599 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01022823001 19038288 19052599 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015094001 981653 996811 GSVIVG01021922001 5535278 5549969 GO:0006801 superoxide metabolic process The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01021922001 5535278 5549969 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01024323001 891662 894089 GSVIVG01036716001 23399297 23401496 GSVIVG01032203001 21578127 21581173 GSVIVG01025628001 13481613 13491398 GO:0006364 rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. IEA GO:0000172 ribonuclease MRP complex A ribonucleoprotein complex that contains an RNA molecule of the snoRNA family, and cleaves the rRNA precursor as part of rRNA transcript processing. It also has other roles: In S. cerevisiae it is involved in cell cycle-regulated degradation of daughter cell-specific mRNAs, while in mammalian cells it also enters the mitochondria and processes RNAs to create RNA primers for DNA replication. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01025628001 13481613 13491398 GO:0006364 rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. IEA GO:0005655 nucleolar ribonuclease P complex A ribonuclease P complex located in the nucleolus of a eukaryotic cell, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. Eukaryotic nucleolar ribonuclease P complexes generally contain a single RNA molecule that is necessary but not sufficient for catalysis, and several protein molecules. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01025628001 13481613 13491398 GO:0006364 rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. IEA GO:0030677 ribonuclease P complex A ribonucleoprotein complex that catalyzes cleavage of the leader sequence of precursor tRNAs (pre-tRNAs), generating the mature 5' end of tRNAs. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01025628001 13481613 13491398 GO:0006379 mRNA cleavage Any process by which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner. IEA GO:0000172 ribonuclease MRP complex A ribonucleoprotein complex that contains an RNA molecule of the snoRNA family, and cleaves the rRNA precursor as part of rRNA transcript processing. It also has other roles: In S. cerevisiae it is involved in cell cycle-regulated degradation of daughter cell-specific mRNAs, while in mammalian cells it also enters the mitochondria and processes RNAs to create RNA primers for DNA replication. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01025628001 13481613 13491398 GO:0006379 mRNA cleavage Any process by which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner. IEA GO:0005655 nucleolar ribonuclease P complex A ribonuclease P complex located in the nucleolus of a eukaryotic cell, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. Eukaryotic nucleolar ribonuclease P complexes generally contain a single RNA molecule that is necessary but not sufficient for catalysis, and several protein molecules. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01025628001 13481613 13491398 GO:0006379 mRNA cleavage Any process by which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner. IEA GO:0030677 ribonuclease P complex A ribonucleoprotein complex that catalyzes cleavage of the leader sequence of precursor tRNAs (pre-tRNAs), generating the mature 5' end of tRNAs. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01025628001 13481613 13491398 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA GO:0000172 ribonuclease MRP complex A ribonucleoprotein complex that contains an RNA molecule of the snoRNA family, and cleaves the rRNA precursor as part of rRNA transcript processing. It also has other roles: In S. cerevisiae it is involved in cell cycle-regulated degradation of daughter cell-specific mRNAs, while in mammalian cells it also enters the mitochondria and processes RNAs to create RNA primers for DNA replication. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01025628001 13481613 13491398 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA GO:0005655 nucleolar ribonuclease P complex A ribonuclease P complex located in the nucleolus of a eukaryotic cell, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. Eukaryotic nucleolar ribonuclease P complexes generally contain a single RNA molecule that is necessary but not sufficient for catalysis, and several protein molecules. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01025628001 13481613 13491398 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA GO:0030677 ribonuclease P complex A ribonucleoprotein complex that catalyzes cleavage of the leader sequence of precursor tRNAs (pre-tRNAs), generating the mature 5' end of tRNAs. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01025628001 13481613 13491398 GO:0006364 rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. IEA GO:0000172 ribonuclease MRP complex A ribonucleoprotein complex that contains an RNA molecule of the snoRNA family, and cleaves the rRNA precursor as part of rRNA transcript processing. It also has other roles: In S. cerevisiae it is involved in cell cycle-regulated degradation of daughter cell-specific mRNAs, while in mammalian cells it also enters the mitochondria and processes RNAs to create RNA primers for DNA replication. IEA Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA. IEA GO:0004540 ribonuclease activity GSVIVG01025628001 13481613 13491398 GO:0006364 rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. IEA GO:0005655 nucleolar ribonuclease P complex A ribonuclease P complex located in the nucleolus of a eukaryotic cell, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. Eukaryotic nucleolar ribonuclease P complexes generally contain a single RNA molecule that is necessary but not sufficient for catalysis, and several protein molecules. IEA Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA. IEA GO:0004540 ribonuclease activity GSVIVG01025628001 13481613 13491398 GO:0006364 rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. IEA GO:0030677 ribonuclease P complex A ribonucleoprotein complex that catalyzes cleavage of the leader sequence of precursor tRNAs (pre-tRNAs), generating the mature 5' end of tRNAs. IEA Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA. IEA GO:0004540 ribonuclease activity GSVIVG01025628001 13481613 13491398 GO:0006379 mRNA cleavage Any process by which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner. IEA GO:0000172 ribonuclease MRP complex A ribonucleoprotein complex that contains an RNA molecule of the snoRNA family, and cleaves the rRNA precursor as part of rRNA transcript processing. It also has other roles: In S. cerevisiae it is involved in cell cycle-regulated degradation of daughter cell-specific mRNAs, while in mammalian cells it also enters the mitochondria and processes RNAs to create RNA primers for DNA replication. IEA Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA. IEA GO:0004540 ribonuclease activity GSVIVG01025628001 13481613 13491398 GO:0006379 mRNA cleavage Any process by which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner. IEA GO:0005655 nucleolar ribonuclease P complex A ribonuclease P complex located in the nucleolus of a eukaryotic cell, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. Eukaryotic nucleolar ribonuclease P complexes generally contain a single RNA molecule that is necessary but not sufficient for catalysis, and several protein molecules. IEA Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA. IEA GO:0004540 ribonuclease activity GSVIVG01025628001 13481613 13491398 GO:0006379 mRNA cleavage Any process by which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner. IEA GO:0030677 ribonuclease P complex A ribonucleoprotein complex that catalyzes cleavage of the leader sequence of precursor tRNAs (pre-tRNAs), generating the mature 5' end of tRNAs. IEA Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA. IEA GO:0004540 ribonuclease activity GSVIVG01025628001 13481613 13491398 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA GO:0000172 ribonuclease MRP complex A ribonucleoprotein complex that contains an RNA molecule of the snoRNA family, and cleaves the rRNA precursor as part of rRNA transcript processing. It also has other roles: In S. cerevisiae it is involved in cell cycle-regulated degradation of daughter cell-specific mRNAs, while in mammalian cells it also enters the mitochondria and processes RNAs to create RNA primers for DNA replication. IEA Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA. IEA GO:0004540 ribonuclease activity GSVIVG01025628001 13481613 13491398 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA GO:0005655 nucleolar ribonuclease P complex A ribonuclease P complex located in the nucleolus of a eukaryotic cell, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. Eukaryotic nucleolar ribonuclease P complexes generally contain a single RNA molecule that is necessary but not sufficient for catalysis, and several protein molecules. IEA Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA. IEA GO:0004540 ribonuclease activity GSVIVG01025628001 13481613 13491398 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA GO:0030677 ribonuclease P complex A ribonucleoprotein complex that catalyzes cleavage of the leader sequence of precursor tRNAs (pre-tRNAs), generating the mature 5' end of tRNAs. IEA Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA. IEA GO:0004540 ribonuclease activity GSVIVG01003955001 14030385 14035712 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003955001 14030385 14035712 GO:0016114 terpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003955001 14030385 14035712 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. IEA GO:0008661 1-deoxy-D-xylulose-5-phosphate synthase activity GSVIVG01003955001 14030385 14035712 GO:0016114 terpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure. IEA Catalysis of the reaction: pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. IEA GO:0008661 1-deoxy-D-xylulose-5-phosphate synthase activity GSVIVG01003955001 14030385 14035712 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide. IEA GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor GSVIVG01003955001 14030385 14035712 GO:0016114 terpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure. IEA Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide. IEA GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor GSVIVG01024239001 133174 134689 GSVIVG01023747001 10563723 10564574 GSVIVG01022512001 4215073 4215954 GSVIVG01008885001 3134531 3146368 GSVIVG01005785001 21927527 21928074 GSVIVG01014835001 10332463 10337676 GSVIVG01037993001 12136607 12204378 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01037993001 12136607 12204378 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01037993001 12136607 12204378 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01037993001 12136607 12204378 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01037993001 12136607 12204378 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01037993001 12136607 12204378 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019432001 659541 661587 GSVIVG01008142001 5419518 5430208 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01008142001 5419518 5430208 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01008142001 5419518 5430208 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01008142001 5419518 5430208 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01008142001 5419518 5430208 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008142001 5419518 5430208 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008142001 5419518 5430208 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008142001 5419518 5430208 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01009248001 6644093 6648772 GO:0006796 phosphate metabolic process The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01009248001 6644093 6648772 GO:0006796 phosphate metabolic process The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: diphosphate + H2O = 2 phosphate. IEA GO:0004427 inorganic diphosphatase activity GSVIVG01012772001 23508908 23510066 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012772001 23508908 23510066 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012772001 23508908 23510066 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01012772001 23508908 23510066 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01012772001 23508908 23510066 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01012772001 23508908 23510066 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01037115001 28988813 28989566 GSVIVG01012888001 6535364 6542360 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012888001 6535364 6542360 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01012888001 6535364 6542360 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01006628001 27148014 27149037 GSVIVG01023576001 9418500 9423244 GSVIVG01032737001 1157818 1164618 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01032737001 1157818 1164618 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA A ligand-dependent receptor found in the nucleus of the cell. IEA GO:0004879 ligand-dependent nuclear receptor activity GSVIVG01035168001 12508618 12602202 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035168001 12508618 12602202 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01035168001 12508618 12602202 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01000584001 6843366 6852105 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000584001 6843366 6852105 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01014294001 2380814 2384147 GSVIVG01006341001 330532 336864 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004185 serine-type carboxypeptidase activity GSVIVG01002627001 35473807 35475582 GO:0005795 Golgi stack The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack. IEA Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid. IEA GO:0008378 galactosyltransferase activity GSVIVG01032831001 403657 408328 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01032831001 403657 408328 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01019246001 2617469 2617615 Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01035983001 6796378 6801764 GSVIVG01010262001 18566883 18567791 GSVIVG01015630001 14403150 14403506 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01015630001 14403150 14403506 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030132 clathrin coat of coated pit The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01015630001 14403150 14403506 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01015630001 14403150 14403506 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030132 clathrin coat of coated pit The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01015630001 14403150 14403506 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01015630001 14403150 14403506 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030132 clathrin coat of coated pit The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018142001 6989196 6989776 GO:0009611 response to wounding A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism. IEA Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme. IEA GO:0004867 serine-type endopeptidase inhibitor activity GSVIVG01012479001 13673095 13679538 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01033800001 17725858 17728519 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Combining with a leukotriene to initiate a change in cell activity. Leukotrienes are pharmacologically active substances with a set of three conjugated double bonds; some contain a peptide moiety based on cysteine. IEA GO:0004974 leukotriene receptor activity GSVIVG01033800001 17725858 17728519 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with a leukotriene to initiate a change in cell activity. Leukotrienes are pharmacologically active substances with a set of three conjugated double bonds; some contain a peptide moiety based on cysteine. IEA GO:0004974 leukotriene receptor activity GSVIVG01033800001 17725858 17728519 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Combining with a leukotriene to initiate a change in cell activity. Leukotrienes are pharmacologically active substances with a set of three conjugated double bonds; some contain a peptide moiety based on cysteine. IEA GO:0004974 leukotriene receptor activity GSVIVG01033800001 17725858 17728519 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with a leukotriene to initiate a change in cell activity. Leukotrienes are pharmacologically active substances with a set of three conjugated double bonds; some contain a peptide moiety based on cysteine. IEA GO:0004974 leukotriene receptor activity GSVIVG01033800001 17725858 17728519 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033800001 17725858 17728519 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033800001 17725858 17728519 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033800001 17725858 17728519 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033800001 17725858 17728519 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. IEA GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GSVIVG01033800001 17725858 17728519 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. IEA GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GSVIVG01033800001 17725858 17728519 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. IEA GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GSVIVG01033800001 17725858 17728519 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. IEA GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GSVIVG01033214001 9836538 9838712 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027236001 17806556 17809972 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027236001 17806556 17809972 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027236001 17806556 17809972 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027236001 17806556 17809972 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027236001 17806556 17809972 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01027236001 17806556 17809972 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01026571001 21559587 21561962 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01026571001 21559587 21561962 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01026571001 21559587 21561962 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01026571001 21559587 21561962 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01026571001 21559587 21561962 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01026571001 21559587 21561962 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01026571001 21559587 21561962 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026571001 21559587 21561962 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026571001 21559587 21561962 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01026571001 21559587 21561962 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01030367001 5036656 5043778 GSVIVG01012730001 1067226 1075577 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01012730001 1067226 1075577 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01012730001 1067226 1075577 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01012730001 1067226 1075577 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01012730001 1067226 1075577 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012730001 1067226 1075577 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014336001 2754665 2757270 GSVIVG01032991001 24933092 24937057 Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01006378001 25369599 25370809 GSVIVG01006065001 40967560 40968707 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01009772001 11161705 11165472 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009772001 11161705 11165472 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009772001 11161705 11165472 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01009772001 11161705 11165472 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01009772001 11161705 11165472 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01009772001 11161705 11165472 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01009315001 7297069 7303262 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: phosphatidylcholine + a sterol = a sterol ester + 1-acylglycerophosphocholine. IEA GO:0004607 phosphatidylcholine-sterol O-acyltransferase activity GSVIVG01019518001 1267448 1273671 GO:0006269 DNA replication, synthesis of RNA primer The synthesis of a short RNA polymer, usually 4-15 nucleotides long, using one strand of unwound DNA as a template; the RNA then serves as a primer from which DNA polymerases extend synthesis. IEA Catalysis of the synthesis of a short RNA primer on a DNA template, providing a free 3'-OH that can be extended by DNA-directed DNA polymerases. Catalyzed by a DNA-directed RNA polymerase that forms a complex with alpha DNA polymerase. IEA GO:0003896 DNA primase activity GSVIVG01034996001 771998 782548 GSVIVG01038537001 11242017 11242220 GSVIVG01007713001 10011352 10014827 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01007713001 10011352 10014827 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01007713001 10011352 10014827 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01007713001 10011352 10014827 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037650001 6547395 6550650 GSVIVG01036595001 18837728 18841561 GSVIVG01003663001 11888686 11889702 GSVIVG01024294001 613592 616135 GO:0006559 L-phenylalanine catabolic process The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024294001 613592 616135 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024294001 613592 616135 GO:0006559 L-phenylalanine catabolic process The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of ammonia (NH3) to another substance via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. IEA GO:0016211 ammonia ligase activity GSVIVG01024294001 613592 616135 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of ammonia (NH3) to another substance via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. IEA GO:0016211 ammonia ligase activity GSVIVG01024294001 613592 616135 GO:0006559 L-phenylalanine catabolic process The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate. IEA GO:0016841 ammonia-lyase activity GSVIVG01024294001 613592 616135 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate. IEA GO:0016841 ammonia-lyase activity GSVIVG01030454001 5689770 5696652 GSVIVG01036162001 19947462 19949757 GSVIVG01017572001 10792005 10792827 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01017572001 10792005 10792827 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01002824001 36816401 36822005 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01023076001 15762199 15762956 GSVIVG01036361001 4217610 4220002 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01036361001 4217610 4220002 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01028017001 3217013 3219476 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01028017001 3217013 3219476 GO:0016068 type I hypersensitivity An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells or basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01032827001 456630 461257 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01032827001 456630 461257 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01032827001 456630 461257 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032827001 456630 461257 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032827001 456630 461257 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01032827001 456630 461257 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01011318001 8398995 8407306 GSVIVG01001281001 4957741 4960852 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01001281001 4957741 4960852 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001281001 4957741 4960852 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01001281001 4957741 4960852 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01010312001 19296065 19297360 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01015578001 5130454 5140550 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01001135001 22888195 22892828 GSVIVG01008398001 2495808 2498821 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008398001 2495808 2498821 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01008398001 2495808 2498821 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01000320001 11339790 11346406 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01000320001 11339790 11346406 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01016848001 1916905 1928084 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01016848001 1916905 1928084 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt. IEA GO:0004525 ribonuclease III activity GSVIVG01030484001 6086925 6092092 GSVIVG01011858001 3520168 3521895 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar. IEA GO:0008375 acetylglucosaminyltransferase activity GSVIVG01014102001 427492 430727 GSVIVG01034245001 13415683 13419746 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01034245001 13415683 13419746 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01034245001 13415683 13419746 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01022168001 17191404 17193934 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01022168001 17191404 17193934 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of the reaction: 2 L-ascorbate + O2 = 2 dehydroascorbate + 2 H2O. IEA GO:0008447 L-ascorbate oxidase activity GSVIVG01022168001 17191404 17193934 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01030612001 7166661 7169865 GSVIVG01025910001 27324195 27327611 GSVIVG01030532001 6529022 6531111 GSVIVG01026252001 14924782 14928263 GO:0006829 zinc ion transport The directed movement of zinc (Zn) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. IEA GO:0005385 zinc ion transmembrane transporter activity GSVIVG01026252001 14924782 14928263 GO:0006829 zinc ion transport The directed movement of zinc (Zn) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. IEA GO:0005385 zinc ion transmembrane transporter activity GSVIVG01026252001 14924782 14928263 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. IEA GO:0005385 zinc ion transmembrane transporter activity GSVIVG01026252001 14924782 14928263 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. IEA GO:0005385 zinc ion transmembrane transporter activity GSVIVG01026252001 14924782 14928263 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. IEA GO:0005385 zinc ion transmembrane transporter activity GSVIVG01026252001 14924782 14928263 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. IEA GO:0005385 zinc ion transmembrane transporter activity GSVIVG01026252001 14924782 14928263 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. IEA GO:0005385 zinc ion transmembrane transporter activity GSVIVG01026252001 14924782 14928263 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. IEA GO:0005385 zinc ion transmembrane transporter activity GSVIVG01026252001 14924782 14928263 GO:0006829 zinc ion transport The directed movement of zinc (Zn) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01026252001 14924782 14928263 GO:0006829 zinc ion transport The directed movement of zinc (Zn) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01026252001 14924782 14928263 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01026252001 14924782 14928263 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01026252001 14924782 14928263 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01026252001 14924782 14928263 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01026252001 14924782 14928263 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01026252001 14924782 14928263 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01026252001 14924782 14928263 GO:0006829 zinc ion transport The directed movement of zinc (Zn) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01026252001 14924782 14928263 GO:0006829 zinc ion transport The directed movement of zinc (Zn) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01026252001 14924782 14928263 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01026252001 14924782 14928263 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01026252001 14924782 14928263 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01026252001 14924782 14928263 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01026252001 14924782 14928263 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01026252001 14924782 14928263 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01018116001 6661342 6682869 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01035534001 2093626 2097352 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01035534001 2093626 2097352 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01022289001 18234482 18275226 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01038492001 10338448 10339615 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA GSVIVG01031228001 1038356 1040154 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA GSVIVG01017121001 4378607 4394854 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01017121001 4378607 4394854 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01017121001 4378607 4394854 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017121001 4378607 4394854 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01037783001 7834637 7836831 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01011592001 6158391 6160886 GSVIVG01013071001 8764178 8764669 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01016967001 3030078 3040592 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01016967001 3030078 3040592 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01020881001 17782034 17785629 GSVIVG01025677001 13007552 13010375 GSVIVG01003919001 13651075 13654296 GSVIVG01038784001 878588 884603 GO:0009113 purine base biosynthetic process The chemical reactions and pathways resulting in the formation of purine bases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01038784001 878588 884603 GO:0009113 purine base biosynthetic process The chemical reactions and pathways resulting in the formation of purine bases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine. IEA Catalysis of the reaction: ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N1-(5-phospho-D-ribosyl)glycinamide. IEA GO:0004637 phosphoribosylamine-glycine ligase activity GSVIVG01038784001 878588 884603 GO:0009113 purine base biosynthetic process The chemical reactions and pathways resulting in the formation of purine bases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030535001 6548227 6561979 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. IEA GO:0004725 protein tyrosine phosphatase activity GSVIVG01030535001 6548227 6561979 GO:0016311 dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. IEA Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. IEA GO:0004725 protein tyrosine phosphatase activity GSVIVG01030535001 6548227 6561979 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA Catalysis of the reaction: protein serine/threonine/tyrosine phosphate + H2O = protein serine/threonine/tyrosine + phosphate. IEA GO:0008138 protein tyrosine/serine/threonine phosphatase activity GSVIVG01030535001 6548227 6561979 GO:0016311 dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. IEA Catalysis of the reaction: protein serine/threonine/tyrosine phosphate + H2O = protein serine/threonine/tyrosine + phosphate. IEA GO:0008138 protein tyrosine/serine/threonine phosphatase activity GSVIVG01030535001 6548227 6561979 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. IEA GO:0016791 phosphatase activity GSVIVG01030535001 6548227 6561979 GO:0016311 dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. IEA Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. IEA GO:0016791 phosphatase activity GSVIVG01034163001 14732793 14732876 GSVIVG01020771001 2172268 2184432 Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01008017001 6658310 6659280 GSVIVG01006908001 29056597 29058877 GSVIVG01028148001 4203221 4203995 GSVIVG01012380001 277565 278361 GSVIVG01021080001 13951047 13954128 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01021080001 13951047 13954128 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01021080001 13951047 13954128 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015934 large ribosomal subunit The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01021080001 13951047 13954128 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01003301001 8694995 8698030 GSVIVG01013636001 2021148 2024164 GSVIVG01018604001 12380477 12381408 Stops, prevents or reduces the activity of an enzyme. IEA GO:0004857 enzyme inhibitor activity GSVIVG01018604001 12380477 12381408 Catalysis of the reaction: pectin + n H2O = n methanol + pectate. IEA GO:0030599 pectinesterase activity GSVIVG01031494001 17960437 17967861 GSVIVG01035038001 1083853 1085029 GSVIVG01028167001 4353850 4361731 GO:0016481 negative regulation of transcription Any cellular process that stops, prevents or reduces the frequency, rate or extent of transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01011469001 29893898 29895110 GSVIVG01019863001 3946577 3947398 GSVIVG01035510001 1899433 1900571 GSVIVG01028738001 19252974 19259256 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01028738001 19252974 19259256 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01033469001 20433577 20443239 GSVIVG01018102001 6553345 6565149 GSVIVG01014016001 9008013 9008366 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01014016001 9008013 9008366 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01014016001 9008013 9008366 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01014016001 9008013 9008366 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01014016001 9008013 9008366 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01014016001 9008013 9008366 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01019499001 1128686 1137285 GSVIVG01009229001 6461318 6462569 GSVIVG01018733001 20315432 20318762 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01015047001 707516 707944 GSVIVG01029332001 14484812 14486185 GSVIVG01008212001 4601342 4613394 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01008212001 4601342 4613394 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01008212001 4601342 4613394 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01008212001 4601342 4613394 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035117001 1575485 1580625 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026880001 19676542 19681422 GSVIVG01008991001 4097930 4113909 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008991001 4097930 4113909 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008991001 4097930 4113909 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA. IEA GO:0003989 acetyl-CoA carboxylase activity GSVIVG01008991001 4097930 4113909 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA. IEA GO:0003989 acetyl-CoA carboxylase activity GSVIVG01008991001 4097930 4113909 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008991001 4097930 4113909 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008991001 4097930 4113909 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Interacting selectively and non-covalently with biotin (cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid), the (+) enantiomer of which is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions. IEA GO:0009374 biotin binding GSVIVG01008991001 4097930 4113909 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with biotin (cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid), the (+) enantiomer of which is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions. IEA GO:0009374 biotin binding GSVIVG01008991001 4097930 4113909 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01008991001 4097930 4113909 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01020875001 723853 726025 GSVIVG01004964001 17119192 17121210 GO:0006461 protein complex assembly The aggregation, arrangement and bonding together of a set of components to form a protein complex. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells. IEA GO:0015232 heme transporter activity GSVIVG01004964001 17119192 17121210 GO:0008535 respiratory chain complex IV assembly The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase), the terminal member of the respiratory chain of the mitochondrion and some aerobic bacteria. Cytochrome c oxidases are multi-subunit enzymes containing from 13 subunits in the mammalian mitochondrial form to 3-4 subunits in the bacterial forms. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells. IEA GO:0015232 heme transporter activity GSVIVG01004964001 17119192 17121210 GO:0015886 heme transport The directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells. IEA GO:0015232 heme transporter activity GSVIVG01004964001 17119192 17121210 GO:0017004 cytochrome complex assembly The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells. IEA GO:0015232 heme transporter activity GSVIVG01038202001 24309756 24310842 GSVIVG01027063001 18219459 18228512 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01018706001 10935171 10935748 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033208001 9772423 9772785 GSVIVG01021213001 2584417 2596929 GSVIVG01036233001 8496412 8502789 GSVIVG01030265001 9729181 9729602 GSVIVG01008214001 4566359 4592434 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01008214001 4566359 4592434 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01008214001 4566359 4592434 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01008214001 4566359 4592434 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013326001 12107179 12108020 GSVIVG01021278001 3313424 3322980 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01021278001 3313424 3322980 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01021278001 3313424 3322980 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01021278001 3313424 3322980 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027514001 16041907 16045499 GSVIVG01000797001 226536 228314 GO:0006270 DNA-dependent DNA replication initiation The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action. IEA GSVIVG01013847001 5169932 5170219 GSVIVG01035463001 1464949 1466397 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01008056001 6180589 6181177 GSVIVG01028413001 7340852 7348167 GO:0006935 chemotaxis The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with anaphylatoxin C3a to initiate a change in cell activity. IEA GO:0004943 C3a anaphylatoxin receptor activity GSVIVG01028413001 7340852 7348167 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with anaphylatoxin C3a to initiate a change in cell activity. IEA GO:0004943 C3a anaphylatoxin receptor activity GSVIVG01009572001 9520803 9521700 GSVIVG01023974001 1980618 2018018 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01023974001 1980618 2018018 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01019772001 3200566 3204790 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019772001 3200566 3204790 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019772001 3200566 3204790 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01019772001 3200566 3204790 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01010606001 16088472 16095546 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01010606001 16088472 16095546 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01010606001 16088472 16095546 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01010606001 16088472 16095546 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01031743001 3991830 3999550 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031743001 3991830 3999550 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01021141001 1782218 1786685 GSVIVG01023249001 20576997 20595132 GO:0001522 pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01023249001 20576997 20595132 GO:0009451 RNA modification The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01023249001 20576997 20595132 GO:0001522 pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs. IEA Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. IEA GO:0009982 pseudouridine synthase activity GSVIVG01023249001 20576997 20595132 GO:0009451 RNA modification The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. IEA Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. IEA GO:0009982 pseudouridine synthase activity GSVIVG01006295001 24617722 24618468 GSVIVG01025622001 13523827 13527339 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01025622001 13523827 13527339 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01025622001 13523827 13527339 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01015272001 2308784 2310747 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01024879001 6296349 6298126 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024879001 6296349 6298126 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024879001 6296349 6298126 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024879001 6296349 6298126 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01024879001 6296349 6298126 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01024879001 6296349 6298126 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01024879001 6296349 6298126 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024879001 6296349 6298126 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024879001 6296349 6298126 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024879001 6296349 6298126 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01024879001 6296349 6298126 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01024879001 6296349 6298126 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01024879001 6296349 6298126 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024879001 6296349 6298126 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024879001 6296349 6298126 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01035019001 937046 939769 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01011740001 4665984 4672737 GSVIVG01012212001 523827 526024 GSVIVG01030608001 7139319 7142744 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030608001 7139319 7142744 GO:0019752 carboxylic acid metabolic process The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030608001 7139319 7142744 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: isocitrate = succinate + glyoxylate. IEA GO:0004451 isocitrate lyase activity GSVIVG01030608001 7139319 7142744 GO:0019752 carboxylic acid metabolic process The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). IEA Catalysis of the reaction: isocitrate = succinate + glyoxylate. IEA GO:0004451 isocitrate lyase activity GSVIVG01006533001 42967607 42968501 GSVIVG01011052001 1956032 1958349 GSVIVG01033112001 25805261 25806810 GSVIVG01012303001 13232852 13233825 GSVIVG01002647001 35588888 35589577 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01002647001 35588888 35589577 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids. IEA GO:0004518 nuclease activity GSVIVG01002647001 35588888 35589577 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029926001 1547506 1560413 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01029926001 1547506 1560413 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01029926001 1547506 1560413 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01029926001 1547506 1560413 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01011298001 7903007 7903216 GSVIVG01033717001 18385618 18387861 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01033717001 18385618 18387861 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01033717001 18385618 18387861 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000604001 6612511 6618381 GSVIVG01019841001 3799837 3800512 GSVIVG01020040001 11250995 11256179 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GSVIVG01016464001 3641296 3654366 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1). IEA GO:0004326 tetrahydrofolylpolyglutamate synthase activity GSVIVG01016464001 3641296 3654366 GO:0009396 folic acid and derivative biosynthetic process The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. IEA Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1). IEA GO:0004326 tetrahydrofolylpolyglutamate synthase activity GSVIVG01016464001 3641296 3654366 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016464001 3641296 3654366 GO:0009396 folic acid and derivative biosynthetic process The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016464001 3641296 3654366 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01016464001 3641296 3654366 GO:0009396 folic acid and derivative biosynthetic process The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01008695001 1262260 1262685 GSVIVG01016810001 1575915 1581004 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01016810001 1575915 1581004 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016810001 1575915 1581004 Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01006267001 24337126 24352573 GSVIVG01018060001 5938849 5945621 GO:0007067 mitosis A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell. IEA GO:0005681 spliceosomal complex Any of a series of ribonucleoprotein complexes that contain RNA and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the splicing of a messenger RNA primary transcript to excise an intron. IEA GSVIVG01035830001 4723814 4732677 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035830001 4723814 4732677 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01005048001 17687712 17690732 GO:0006730 one-carbon metabolic process The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. IEA Catalysis of the reaction: H2CO3 = CO2 + H2O. IEA GO:0004089 carbonate dehydratase activity GSVIVG01005048001 17687712 17690732 GO:0006730 one-carbon metabolic process The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01025784001 11898121 11899014 GSVIVG01012149001 1030308 1032374 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01008764001 1783159 1783284 GSVIVG01016443001 3862365 3865381 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01016443001 3862365 3865381 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01016443001 3862365 3865381 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01016443001 3862365 3865381 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01009943001 12682735 12691905 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0008021 synaptic vesicle A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and is secreted these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01009943001 12682735 12691905 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01031871001 5017309 5018886 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01031871001 5017309 5018886 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01031871001 5017309 5018886 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01031871001 5017309 5018886 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01005930001 22809778 22816840 GSVIVG01000147001 15640823 15646075 GSVIVG01018859001 19164015 19178113 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018859001 19164015 19178113 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01018859001 19164015 19178113 Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01027778001 7639983 7640102 GSVIVG01034630001 13688504 13689190 GSVIVG01013474001 99418 105675 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GSVIVG01027620001 14992324 14994786 GSVIVG01001344001 23779806 23790606 GSVIVG01023063001 16005400 16006135 GSVIVG01022400001 19680834 19700406 GSVIVG01005134001 18481564 18482767 GSVIVG01026325001 13993052 14018155 GSVIVG01036080001 20951348 20959324 GSVIVG01002634001 35552314 35555514 GSVIVG01007422001 31739276 31739674 GSVIVG01015409001 3365564 3366469 GSVIVG01025710001 12766901 12786091 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025028001 5163510 5173592 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025028001 5163510 5173592 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025028001 5163510 5173592 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025028001 5163510 5173592 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025028001 5163510 5173592 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025028001 5163510 5173592 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01025028001 5163510 5173592 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01025028001 5163510 5173592 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01025028001 5163510 5173592 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01025028001 5163510 5173592 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01025028001 5163510 5173592 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025028001 5163510 5173592 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025028001 5163510 5173592 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025028001 5163510 5173592 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025028001 5163510 5173592 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025028001 5163510 5173592 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01025028001 5163510 5173592 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01025028001 5163510 5173592 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01025028001 5163510 5173592 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01025028001 5163510 5173592 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01000419001 7742869 7744969 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01017753001 3158391 3159842 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01019664001 2313232 2315418 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019664001 2313232 2315418 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01029743001 14017069 14026522 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01019080001 16950432 16953530 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GSVIVG01009981001 13037311 13042345 GSVIVG01031338001 262785 267677 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01030083001 9694089 9698217 GSVIVG01025922001 27219980 27221408 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025922001 27219980 27221408 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0010181 FMN binding GSVIVG01025922001 27219980 27221408 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01027564001 15537179 15539404 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01027564001 15537179 15539404 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01027564001 15537179 15539404 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01027564001 15537179 15539404 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009399001 7996242 7998773 GO:0016068 type I hypersensitivity An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells or basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01013359001 987295 992640 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0031227 intrinsic to endoplasmic reticulum membrane Located in the endoplasmic reticulum membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01013359001 987295 992640 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0031227 intrinsic to endoplasmic reticulum membrane Located in the endoplasmic reticulum membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01013359001 987295 992640 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0031227 intrinsic to endoplasmic reticulum membrane Located in the endoplasmic reticulum membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01016639001 2257959 2273273 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016639001 2257959 2273273 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01016639001 2257959 2273273 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. IEA GO:0004563 beta-N-acetylhexosaminidase activity GSVIVG01016639001 2257959 2273273 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01036407001 4711164 4725714 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012700001 822151 829404 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012700001 822151 829404 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01026755001 6258460 6258561 GSVIVG01008310001 3361915 3388653 GSVIVG01009309001 7260114 7260686 GO:0008283 cell proliferation The multiplication or reproduction of cells, resulting in the expansion of a cell population. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation. IEA GO:0008083 growth factor activity GSVIVG01020294001 21776088 21779786 GSVIVG01019789001 3301517 3302335 GSVIVG01005252001 19860398 19866198 GSVIVG01006955001 29416151 29420850 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01006955001 29416151 29420850 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01021435001 5307081 5309181 GSVIVG01021671001 9059785 9071919 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01021671001 9059785 9071919 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01021671001 9059785 9071919 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01021671001 9059785 9071919 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01021671001 9059785 9071919 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008159001 5199097 5205717 GSVIVG01014628001 7925931 7935919 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01014628001 7925931 7935919 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01014628001 7925931 7935919 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014628001 7925931 7935919 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014628001 7925931 7935919 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01014628001 7925931 7935919 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01014628001 7925931 7935919 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01014628001 7925931 7935919 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01014628001 7925931 7935919 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01014628001 7925931 7935919 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01014100001 375194 383468 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01014100001 375194 383468 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01023159001 21796268 21801648 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031441001 18543610 18553218 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0008236 serine-type peptidase activity GSVIVG01027749001 7382401 7384116 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01012231001 381267 382921 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01012231001 381267 382921 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01012231001 381267 382921 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01012231001 381267 382921 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01007964001 7109391 7124378 GSVIVG01030979001 20192428 20212881 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008435001 2090857 2094257 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01008435001 2090857 2094257 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01008435001 2090857 2094257 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01008435001 2090857 2094257 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01008435001 2090857 2094257 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036202001 9067763 9069855 GSVIVG01035039001 1085706 1087504 GSVIVG01024731001 7383811 7386408 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01024731001 7383811 7386408 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01024731001 7383811 7386408 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01024731001 7383811 7386408 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026776001 6945060 6946755 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035895001 5443112 5446547 GSVIVG01026322001 13932084 13938476 GSVIVG01009850001 11774360 11775955 GSVIVG01034359001 17439656 17516686 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01008227001 4477986 4479788 GSVIVG01019668001 2335462 2337426 GSVIVG01034541001 19675813 19677806 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01034541001 19675813 19677806 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01034541001 19675813 19677806 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01002067001 32634668 32645543 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01017394001 7804389 7805707 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: ATP + glycerol = ADP + glycerol 3-phosphate. IEA GO:0004370 glycerol kinase activity GSVIVG01017394001 7804389 7805707 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA Catalysis of the reaction: ATP + glycerol = ADP + glycerol 3-phosphate. IEA GO:0004370 glycerol kinase activity GSVIVG01017394001 7804389 7805707 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01017394001 7804389 7805707 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01023084001 15584311 15590556 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01002954001 37340035 37342636 GSVIVG01013125001 7963836 7972650 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01013125001 7963836 7972650 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01013125001 7963836 7972650 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013125001 7963836 7972650 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013125001 7963836 7972650 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01013125001 7963836 7972650 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01013125001 7963836 7972650 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01013125001 7963836 7972650 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01013125001 7963836 7972650 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01013125001 7963836 7972650 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01037045001 8416042 8423780 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01037045001 8416042 8423780 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01037045001 8416042 8423780 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01014657001 8241015 8247039 GO:0033014 tetrapyrrole biosynthetic process The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. IEA Catalysis of the reaction: 2 5-aminolevulinate = porphobilinogen + 2 H2O. IEA GO:0004655 porphobilinogen synthase activity GSVIVG01014657001 8241015 8247039 GO:0033014 tetrapyrrole biosynthetic process The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01030897001 18569808 18570242 GSVIVG01005316001 20681209 20685724 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01005316001 20681209 20685724 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01005316001 20681209 20685724 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01005316001 20681209 20685724 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034303001 14392804 14393780 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01029473001 22463885 22464115 GSVIVG01001575001 422484 424036 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01019650001 2205554 2206193 GSVIVG01033346001 21326810 21327256 GSVIVG01016904001 2427377 2433837 GO:0006306 DNA methylation The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01016904001 2427377 2433837 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01016904001 2427377 2433837 GO:0006306 DNA methylation The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01016904001 2427377 2433837 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01016904001 2427377 2433837 GO:0006306 DNA methylation The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. IEA Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule. IEA GO:0008170 N-methyltransferase activity GSVIVG01016904001 2427377 2433837 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule. IEA GO:0008170 N-methyltransferase activity GSVIVG01016904001 2427377 2433837 GO:0006306 DNA methylation The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. IEA Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. IEA GO:0008173 RNA methyltransferase activity GSVIVG01016904001 2427377 2433837 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. IEA GO:0008173 RNA methyltransferase activity GSVIVG01021414001 5076867 5078365 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01031010001 20793108 20803660 GSVIVG01001680001 14210516 14227768 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01001680001 14210516 14227768 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01003328001 9089113 9110017 GO:0006464 protein modification process The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. IEA GO:0016881 acid-amino acid ligase activity GSVIVG01021210001 2568210 2572117 Interacting selectively and non-covalently with a specific domain of a protein. IEA GO:0019904 protein domain specific binding GSVIVG01011170001 7688674 7690058 GSVIVG01003682001 12074634 12076964 Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01011889001 3265524 3270097 GO:0016068 type I hypersensitivity An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells or basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines. IEA GSVIVG01024839001 6515104 6517684 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of copper (Cu) ions from one side of a membrane to the other. IEA GO:0005375 copper ion transmembrane transporter activity GSVIVG01022967001 17454127 17455632 GSVIVG01003094001 8619304 8619918 GSVIVG01004636001 39248940 39249282 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01004636001 39248940 39249282 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01004636001 39248940 39249282 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01004636001 39248940 39249282 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01004636001 39248940 39249282 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01004636001 39248940 39249282 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01004636001 39248940 39249282 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01004636001 39248940 39249282 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01004636001 39248940 39249282 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01020194001 9206550 9207586 GSVIVG01024682001 7787972 7788712 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01024682001 7787972 7788712 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds. IEA GO:0015035 protein disulfide oxidoreductase activity GSVIVG01024202001 362662 370801 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01025575001 13948924 13954178 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01000386001 525867 526334 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01002385001 940215 947279 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016651 oxidoreductase activity, acting on NADH or NADPH GSVIVG01007847001 8408076 8412077 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017783001 3447664 3456912 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025535001 14236328 14247891 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025535001 14236328 14247891 GO:0006270 DNA-dependent DNA replication initiation The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025535001 14236328 14247891 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025535001 14236328 14247891 GO:0015995 chlorophyll biosynthetic process The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025535001 14236328 14247891 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025535001 14236328 14247891 GO:0006270 DNA-dependent DNA replication initiation The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025535001 14236328 14247891 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025535001 14236328 14247891 GO:0015995 chlorophyll biosynthetic process The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025535001 14236328 14247891 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025535001 14236328 14247891 GO:0006270 DNA-dependent DNA replication initiation The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025535001 14236328 14247891 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025535001 14236328 14247891 GO:0015995 chlorophyll biosynthetic process The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025535001 14236328 14247891 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + protoporphyrin IX + Mg2+ + H2O = ADP + phosphate + Mg-protoporphyrin IX + 2 H+. IEA GO:0016851 magnesium chelatase activity GSVIVG01025535001 14236328 14247891 GO:0006270 DNA-dependent DNA replication initiation The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + protoporphyrin IX + Mg2+ + H2O = ADP + phosphate + Mg-protoporphyrin IX + 2 H+. IEA GO:0016851 magnesium chelatase activity GSVIVG01025535001 14236328 14247891 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + protoporphyrin IX + Mg2+ + H2O = ADP + phosphate + Mg-protoporphyrin IX + 2 H+. IEA GO:0016851 magnesium chelatase activity GSVIVG01025535001 14236328 14247891 GO:0015995 chlorophyll biosynthetic process The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + protoporphyrin IX + Mg2+ + H2O = ADP + phosphate + Mg-protoporphyrin IX + 2 H+. IEA GO:0016851 magnesium chelatase activity GSVIVG01025535001 14236328 14247891 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01025535001 14236328 14247891 GO:0006270 DNA-dependent DNA replication initiation The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01025535001 14236328 14247891 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01025535001 14236328 14247891 GO:0015995 chlorophyll biosynthetic process The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01025535001 14236328 14247891 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01025535001 14236328 14247891 GO:0006270 DNA-dependent DNA replication initiation The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01025535001 14236328 14247891 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01025535001 14236328 14247891 GO:0015995 chlorophyll biosynthetic process The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01019911001 4404763 4411169 GSVIVG01030916001 18938161 18940512 GO:0006909 phagocytosis The process whereby phagocytes engulf external particulate material. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles. IEA GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA GSVIVG01014682001 8585325 8587301 GSVIVG01035239001 11088568 11103149 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016791001 1392159 1397879 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016791001 1392159 1397879 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01000103001 3550113 3551146 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with manganese (Mn) ions. IEA GO:0030145 manganese ion binding GSVIVG01000103001 3550113 3551146 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Functions in the storage of nutritious substrates. IEA GO:0045735 nutrient reservoir activity GSVIVG01022172001 17207564 17213561 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01022172001 17207564 17213561 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of the reaction: 2 L-ascorbate + O2 = 2 dehydroascorbate + 2 H2O. IEA GO:0008447 L-ascorbate oxidase activity GSVIVG01022172001 17207564 17213561 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033253001 22162819 22165051 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01033253001 22162819 22165051 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01018475001 14567191 14571545 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01018475001 14567191 14571545 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01018475001 14567191 14571545 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008237 metallopeptidase activity GSVIVG01018475001 14567191 14571545 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01018475001 14567191 14571545 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01037031001 8744237 8744878 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01037031001 8744237 8744878 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01037031001 8744237 8744878 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01037031001 8744237 8744878 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01037031001 8744237 8744878 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01037031001 8744237 8744878 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01037031001 8744237 8744878 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01037031001 8744237 8744878 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01020112001 10246455 10250255 GSVIVG01036122001 20413453 20417045 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01036122001 20413453 20417045 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01036122001 20413453 20417045 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01036122001 20413453 20417045 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01036122001 20413453 20417045 GO:0009245 lipid A biosynthetic process The chemical reactions and pathways resulting in the formation of lipid A, the glycolipid moiety of bacterial lipopolysaccharides, consisting of six fatty acyl chains linked to two glucosamine residues. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01036122001 20413453 20417045 GO:0009245 lipid A biosynthetic process The chemical reactions and pathways resulting in the formation of lipid A, the glycolipid moiety of bacterial lipopolysaccharides, consisting of six fatty acyl chains linked to two glucosamine residues. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01036122001 20413453 20417045 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. IEA GO:0004618 phosphoglycerate kinase activity GSVIVG01036122001 20413453 20417045 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Catalysis of the reaction: ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. IEA GO:0004618 phosphoglycerate kinase activity GSVIVG01036122001 20413453 20417045 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. IEA GO:0004618 phosphoglycerate kinase activity GSVIVG01036122001 20413453 20417045 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Catalysis of the reaction: ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. IEA GO:0004618 phosphoglycerate kinase activity GSVIVG01036122001 20413453 20417045 GO:0009245 lipid A biosynthetic process The chemical reactions and pathways resulting in the formation of lipid A, the glycolipid moiety of bacterial lipopolysaccharides, consisting of six fatty acyl chains linked to two glucosamine residues. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. IEA GO:0004618 phosphoglycerate kinase activity GSVIVG01036122001 20413453 20417045 GO:0009245 lipid A biosynthetic process The chemical reactions and pathways resulting in the formation of lipid A, the glycolipid moiety of bacterial lipopolysaccharides, consisting of six fatty acyl chains linked to two glucosamine residues. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Catalysis of the reaction: ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. IEA GO:0004618 phosphoglycerate kinase activity GSVIVG01036122001 20413453 20417045 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the removal of an acetyl moiety from the 2-N position of glucosamine in the lipid A precursor UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine. IEA GO:0008759 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity GSVIVG01036122001 20413453 20417045 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Catalysis of the removal of an acetyl moiety from the 2-N position of glucosamine in the lipid A precursor UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine. IEA GO:0008759 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity GSVIVG01036122001 20413453 20417045 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the removal of an acetyl moiety from the 2-N position of glucosamine in the lipid A precursor UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine. IEA GO:0008759 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity GSVIVG01036122001 20413453 20417045 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Catalysis of the removal of an acetyl moiety from the 2-N position of glucosamine in the lipid A precursor UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine. IEA GO:0008759 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity GSVIVG01036122001 20413453 20417045 GO:0009245 lipid A biosynthetic process The chemical reactions and pathways resulting in the formation of lipid A, the glycolipid moiety of bacterial lipopolysaccharides, consisting of six fatty acyl chains linked to two glucosamine residues. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the removal of an acetyl moiety from the 2-N position of glucosamine in the lipid A precursor UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine. IEA GO:0008759 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity GSVIVG01036122001 20413453 20417045 GO:0009245 lipid A biosynthetic process The chemical reactions and pathways resulting in the formation of lipid A, the glycolipid moiety of bacterial lipopolysaccharides, consisting of six fatty acyl chains linked to two glucosamine residues. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Catalysis of the removal of an acetyl moiety from the 2-N position of glucosamine in the lipid A precursor UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine. IEA GO:0008759 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity GSVIVG01027961001 2846560 2848061 GSVIVG01016852001 1960615 1969322 GSVIVG01008022001 6601153 6607419 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01009297001 7074318 7076680 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01009297001 7074318 7076680 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01016360001 4546379 4547834 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01016360001 4546379 4547834 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01038370001 11215049 11232377 GSVIVG01008305001 3428366 3429668 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01031751001 4047422 4053894 GSVIVG01036220001 8774632 8775630 GSVIVG01035454001 1382338 1384647 Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01031670001 19911022 19937061 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031670001 19911022 19937061 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01015628001 14356254 14357174 GSVIVG01021974001 4829884 4833159 GSVIVG01020544001 4637715 4638846 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01020544001 4637715 4638846 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01024795001 6883894 6887117 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01024795001 6883894 6887117 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01024795001 6883894 6887117 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01024795001 6883894 6887117 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01024795001 6883894 6887117 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024795001 6883894 6887117 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01034942001 271696 308090 GO:0006464 protein modification process The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. IEA GO:0016881 acid-amino acid ligase activity GSVIVG01007453001 32015985 32020969 GSVIVG01003951001 13980105 14001637 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01003951001 13980105 14001637 GO:0006573 valine metabolic process The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01003951001 13980105 14001637 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01003951001 13980105 14001637 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01003951001 13980105 14001637 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH + H+. IEA GO:0004491 methylmalonate-semialdehyde dehydrogenase (acylating) activity GSVIVG01003951001 13980105 14001637 GO:0006573 valine metabolic process The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid. IEA Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH + H+. IEA GO:0004491 methylmalonate-semialdehyde dehydrogenase (acylating) activity GSVIVG01003951001 13980105 14001637 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH + H+. IEA GO:0004491 methylmalonate-semialdehyde dehydrogenase (acylating) activity GSVIVG01003951001 13980105 14001637 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH + H+. IEA GO:0004491 methylmalonate-semialdehyde dehydrogenase (acylating) activity GSVIVG01003951001 13980105 14001637 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. IEA GO:0008173 RNA methyltransferase activity GSVIVG01003951001 13980105 14001637 GO:0006573 valine metabolic process The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid. IEA Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. IEA GO:0008173 RNA methyltransferase activity GSVIVG01003951001 13980105 14001637 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. IEA GO:0008173 RNA methyltransferase activity GSVIVG01003951001 13980105 14001637 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. IEA GO:0008173 RNA methyltransferase activity GSVIVG01003951001 13980105 14001637 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01003951001 13980105 14001637 GO:0006573 valine metabolic process The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01003951001 13980105 14001637 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01003951001 13980105 14001637 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01013345001 12473609 12476856 GSVIVG01012761001 23695426 23699545 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012494001 13887517 13910631 GSVIVG01022790001 16654146 16656614 GSVIVG01023052001 16325192 16331912 GSVIVG01034883001 15879504 15885288 GSVIVG01031528001 17500288 17564204 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01031528001 17500288 17564204 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01031528001 17500288 17564204 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01031528001 17500288 17564204 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031528001 17500288 17564204 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01031528001 17500288 17564204 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01017908001 4540077 4546658 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage. IEA GO:0016209 antioxidant activity GSVIVG01017908001 4540077 4546658 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01011713001 4858517 4862023 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01011713001 4858517 4862023 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01011713001 4858517 4862023 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid. IEA GO:0008825 cyclopropane-fatty-acyl-phospholipid synthase activity GSVIVG01011713001 4858517 4862023 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid. IEA GO:0008825 cyclopropane-fatty-acyl-phospholipid synthase activity GSVIVG01021309001 3809666 3812177 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01036398001 4618014 4618565 GSVIVG01012634001 231820 235554 GSVIVG01014128001 621203 638780 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014128001 621203 638780 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014128001 621203 638780 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014128001 621203 638780 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029531001 21900958 21902274 GSVIVG01012119001 1256060 1261111 GSVIVG01017989001 5303087 5305764 GSVIVG01007535001 12530664 12532984 GO:0006183 GTP biosynthetic process The chemical reactions and pathways resulting in the formation of GTP, guanosine triphosphate. IEA Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. IEA GO:0004550 nucleoside diphosphate kinase activity GSVIVG01007535001 12530664 12532984 GO:0006228 UTP biosynthetic process The chemical reactions and pathways resulting in the formation of UTP, uridine (5'-)triphosphate. IEA Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. IEA GO:0004550 nucleoside diphosphate kinase activity GSVIVG01007535001 12530664 12532984 GO:0006241 CTP biosynthetic process The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate. IEA Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. IEA GO:0004550 nucleoside diphosphate kinase activity GSVIVG01007535001 12530664 12532984 GO:0006183 GTP biosynthetic process The chemical reactions and pathways resulting in the formation of GTP, guanosine triphosphate. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007535001 12530664 12532984 GO:0006228 UTP biosynthetic process The chemical reactions and pathways resulting in the formation of UTP, uridine (5'-)triphosphate. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007535001 12530664 12532984 GO:0006241 CTP biosynthetic process The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001521001 963917 966262 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01032959001 24616826 24623609 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of potassium ions (K+) from one side of a membrane to the other. IEA GO:0015079 potassium ion transmembrane transporter activity GSVIVG01000563001 7031055 7050240 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01000563001 7031055 7050240 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01000563001 7031055 7050240 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01000563001 7031055 7050240 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01000563001 7031055 7050240 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01000563001 7031055 7050240 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01000563001 7031055 7050240 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01000563001 7031055 7050240 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01000563001 7031055 7050240 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01000563001 7031055 7050240 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01009774001 11169565 11174095 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01009774001 11169565 11174095 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009774001 11169565 11174095 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01009774001 11169565 11174095 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01023525001 10299529 10306055 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01023525001 10299529 10306055 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01023525001 10299529 10306055 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. IEA GO:0008483 transaminase activity GSVIVG01023525001 10299529 10306055 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. IEA GO:0008483 transaminase activity GSVIVG01023525001 10299529 10306055 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). IEA GO:0016769 transferase activity, transferring nitrogenous groups GSVIVG01023525001 10299529 10306055 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). IEA GO:0016769 transferase activity, transferring nitrogenous groups GSVIVG01023525001 10299529 10306055 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01023525001 10299529 10306055 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01023525001 10299529 10306055 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01023525001 10299529 10306055 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01023574001 9436319 9437298 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01032723001 1253222 1256626 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032582001 28567444 28570677 GSVIVG01038072001 17422189 17427955 GSVIVG01025856001 11146972 11202402 GSVIVG01001750001 750081 750194 GSVIVG01035619001 2752784 2754121 GSVIVG01030870001 18141203 18142477 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01030870001 18141203 18142477 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01030870001 18141203 18142477 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01030870001 18141203 18142477 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01030870001 18141203 18142477 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01030870001 18141203 18142477 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01025299001 2342416 2350871 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025299001 2342416 2350871 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025299001 2342416 2350871 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025299001 2342416 2350871 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025299001 2342416 2350871 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025299001 2342416 2350871 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025299001 2342416 2350871 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025299001 2342416 2350871 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025299001 2342416 2350871 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025299001 2342416 2350871 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025299001 2342416 2350871 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025299001 2342416 2350871 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025299001 2342416 2350871 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01025299001 2342416 2350871 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01025299001 2342416 2350871 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01025299001 2342416 2350871 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01025299001 2342416 2350871 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01025299001 2342416 2350871 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01025299001 2342416 2350871 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01025299001 2342416 2350871 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01025299001 2342416 2350871 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01025299001 2342416 2350871 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01025299001 2342416 2350871 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01025299001 2342416 2350871 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01025299001 2342416 2350871 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient. IEA GO:0005261 cation channel activity GSVIVG01025299001 2342416 2350871 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient. IEA GO:0005261 cation channel activity GSVIVG01025299001 2342416 2350871 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient. IEA GO:0005261 cation channel activity GSVIVG01025299001 2342416 2350871 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient. IEA GO:0005261 cation channel activity GSVIVG01025299001 2342416 2350871 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient. IEA GO:0005261 cation channel activity GSVIVG01025299001 2342416 2350871 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient. IEA GO:0005261 cation channel activity GSVIVG01025299001 2342416 2350871 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient. IEA GO:0005261 cation channel activity GSVIVG01025299001 2342416 2350871 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient. IEA GO:0005261 cation channel activity GSVIVG01025299001 2342416 2350871 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient. IEA GO:0005261 cation channel activity GSVIVG01025299001 2342416 2350871 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient. IEA GO:0005261 cation channel activity GSVIVG01025299001 2342416 2350871 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient. IEA GO:0005261 cation channel activity GSVIVG01025299001 2342416 2350871 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient. IEA GO:0005261 cation channel activity GSVIVG01025299001 2342416 2350871 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025299001 2342416 2350871 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025299001 2342416 2350871 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025299001 2342416 2350871 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025299001 2342416 2350871 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025299001 2342416 2350871 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025299001 2342416 2350871 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025299001 2342416 2350871 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025299001 2342416 2350871 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025299001 2342416 2350871 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025299001 2342416 2350871 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025299001 2342416 2350871 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025299001 2342416 2350871 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01025299001 2342416 2350871 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01025299001 2342416 2350871 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01025299001 2342416 2350871 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01025299001 2342416 2350871 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01025299001 2342416 2350871 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01025299001 2342416 2350871 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01025299001 2342416 2350871 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01025299001 2342416 2350871 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01025299001 2342416 2350871 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01025299001 2342416 2350871 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01025299001 2342416 2350871 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01025299001 2342416 2350871 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01025299001 2342416 2350871 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01025299001 2342416 2350871 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01025299001 2342416 2350871 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01025299001 2342416 2350871 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01025299001 2342416 2350871 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01025299001 2342416 2350871 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01025299001 2342416 2350871 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01025299001 2342416 2350871 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01025299001 2342416 2350871 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01025299001 2342416 2350871 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01025299001 2342416 2350871 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01025299001 2342416 2350871 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01025299001 2342416 2350871 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01025299001 2342416 2350871 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01025299001 2342416 2350871 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01025299001 2342416 2350871 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01025299001 2342416 2350871 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01025299001 2342416 2350871 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01025299001 2342416 2350871 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01025299001 2342416 2350871 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01025299001 2342416 2350871 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01025299001 2342416 2350871 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01025299001 2342416 2350871 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01025299001 2342416 2350871 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01025299001 2342416 2350871 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01025299001 2342416 2350871 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01025299001 2342416 2350871 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01025299001 2342416 2350871 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01025299001 2342416 2350871 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01025299001 2342416 2350871 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01025299001 2342416 2350871 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01025299001 2342416 2350871 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01025299001 2342416 2350871 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01025299001 2342416 2350871 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01025299001 2342416 2350871 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01025299001 2342416 2350871 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01025299001 2342416 2350871 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01025299001 2342416 2350871 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01025299001 2342416 2350871 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01025299001 2342416 2350871 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01025299001 2342416 2350871 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01025299001 2342416 2350871 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01025299001 2342416 2350871 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01025299001 2342416 2350871 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01025299001 2342416 2350871 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01025299001 2342416 2350871 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01025299001 2342416 2350871 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01008001001 6785896 6793004 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01020586001 3996548 3997201 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01020586001 3996548 3997201 Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01024448001 2701196 2708254 GSVIVG01036949001 17064624 17065595 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01034656001 13065164 13068444 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01034656001 13065164 13068444 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01034656001 13065164 13068444 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01034656001 13065164 13068444 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01034656001 13065164 13068444 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01034656001 13065164 13068444 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01034656001 13065164 13068444 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01034656001 13065164 13068444 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01000445001 8077219 8080179 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01009830001 11613661 11620349 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009830001 11613661 11620349 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009830001 11613661 11620349 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain. IEA GO:0004177 aminopeptidase activity GSVIVG01009830001 11613661 11620349 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain. IEA GO:0004177 aminopeptidase activity GSVIVG01027796001 7840976 7849793 GSVIVG01000891001 3516224 3521644 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01000891001 3516224 3521644 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01029120001 19412309 19439570 GSVIVG01016049001 17911513 17913422 GSVIVG01026762001 6527055 6532297 GO:0009790 embryo development The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01026762001 6527055 6532297 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01010075001 14854163 14859888 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01010075001 14854163 14859888 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01034580001 19128788 19136915 GSVIVG01032075001 22963031 22965812 GSVIVG01031124001 1927945 1956002 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01031124001 1927945 1956002 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01031124001 1927945 1956002 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01031124001 1927945 1956002 GO:0006422 aspartyl-tRNA aminoacylation The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01031124001 1927945 1956002 GO:0006430 lysyl-tRNA aminoacylation The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01031124001 1927945 1956002 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01031124001 1927945 1956002 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01031124001 1927945 1956002 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01031124001 1927945 1956002 GO:0006422 aspartyl-tRNA aminoacylation The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01031124001 1927945 1956002 GO:0006430 lysyl-tRNA aminoacylation The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01031124001 1927945 1956002 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01031124001 1927945 1956002 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01031124001 1927945 1956002 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01031124001 1927945 1956002 GO:0006422 aspartyl-tRNA aminoacylation The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01031124001 1927945 1956002 GO:0006430 lysyl-tRNA aminoacylation The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01031124001 1927945 1956002 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01031124001 1927945 1956002 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01031124001 1927945 1956002 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01031124001 1927945 1956002 GO:0006422 aspartyl-tRNA aminoacylation The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01031124001 1927945 1956002 GO:0006430 lysyl-tRNA aminoacylation The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01031124001 1927945 1956002 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp). IEA GO:0004815 aspartate-tRNA ligase activity GSVIVG01031124001 1927945 1956002 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp). IEA GO:0004815 aspartate-tRNA ligase activity GSVIVG01031124001 1927945 1956002 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp). IEA GO:0004815 aspartate-tRNA ligase activity GSVIVG01031124001 1927945 1956002 GO:0006422 aspartyl-tRNA aminoacylation The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp). IEA GO:0004815 aspartate-tRNA ligase activity GSVIVG01031124001 1927945 1956002 GO:0006430 lysyl-tRNA aminoacylation The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp). IEA GO:0004815 aspartate-tRNA ligase activity GSVIVG01031124001 1927945 1956002 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys). IEA GO:0004824 lysine-tRNA ligase activity GSVIVG01031124001 1927945 1956002 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys). IEA GO:0004824 lysine-tRNA ligase activity GSVIVG01031124001 1927945 1956002 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys). IEA GO:0004824 lysine-tRNA ligase activity GSVIVG01031124001 1927945 1956002 GO:0006422 aspartyl-tRNA aminoacylation The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys). IEA GO:0004824 lysine-tRNA ligase activity GSVIVG01031124001 1927945 1956002 GO:0006430 lysyl-tRNA aminoacylation The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys). IEA GO:0004824 lysine-tRNA ligase activity GSVIVG01031124001 1927945 1956002 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031124001 1927945 1956002 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031124001 1927945 1956002 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031124001 1927945 1956002 GO:0006422 aspartyl-tRNA aminoacylation The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031124001 1927945 1956002 GO:0006430 lysyl-tRNA aminoacylation The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031124001 1927945 1956002 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01031124001 1927945 1956002 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01031124001 1927945 1956002 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01031124001 1927945 1956002 GO:0006422 aspartyl-tRNA aminoacylation The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01031124001 1927945 1956002 GO:0006430 lysyl-tRNA aminoacylation The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01031124001 1927945 1956002 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01031124001 1927945 1956002 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01031124001 1927945 1956002 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01031124001 1927945 1956002 GO:0006422 aspartyl-tRNA aminoacylation The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01031124001 1927945 1956002 GO:0006430 lysyl-tRNA aminoacylation The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01031099001 2353886 2361884 GSVIVG01010280001 18906768 18909820 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01036690001 23829724 23831896 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01036690001 23829724 23831896 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01036690001 23829724 23831896 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01036690001 23829724 23831896 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026822001 20194594 20194785 GSVIVG01014086001 271506 275207 GSVIVG01032545001 28231016 28235514 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005578 proteinaceous extracellular matrix A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01032545001 28231016 28235514 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0031012 extracellular matrix A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as in plants). IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01032545001 28231016 28235514 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005578 proteinaceous extracellular matrix A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01032545001 28231016 28235514 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0031012 extracellular matrix A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as in plants). IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01032545001 28231016 28235514 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005578 proteinaceous extracellular matrix A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008237 metallopeptidase activity GSVIVG01032545001 28231016 28235514 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0031012 extracellular matrix A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as in plants). IEA Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008237 metallopeptidase activity GSVIVG01032545001 28231016 28235514 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005578 proteinaceous extracellular matrix A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008237 metallopeptidase activity GSVIVG01032545001 28231016 28235514 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0031012 extracellular matrix A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as in plants). IEA Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008237 metallopeptidase activity GSVIVG01036711001 23474521 23476369 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01000719001 156375 162295 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Interacting selectively and non-covalently with single-stranded DNA. IEA GO:0003697 single-stranded DNA binding GSVIVG01002723001 36096562 36105867 GSVIVG01036262001 7831321 7854009 GSVIVG01017474001 8971573 8976428 GSVIVG01004012001 1321729 1321969 GSVIVG01019546001 1509184 1518615 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01019546001 1509184 1518615 Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01019546001 1509184 1518615 Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01000675001 20857536 20862189 GSVIVG01010618001 15957117 15959551 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010618001 15957117 15959551 GO:0009089 lysine biosynthetic process via diaminopimelate The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010618001 15957117 15959551 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010618001 15957117 15959551 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01010618001 15957117 15959551 GO:0009089 lysine biosynthetic process via diaminopimelate The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01010618001 15957117 15959551 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01010618001 15957117 15959551 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: 2,3,4,5-tetrahydrodipicolinate + NADP+ = 2,3-dihydrodipicolinate + NADPH + H+. IEA GO:0008839 dihydrodipicolinate reductase activity GSVIVG01010618001 15957117 15959551 GO:0009089 lysine biosynthetic process via diaminopimelate The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: 2,3,4,5-tetrahydrodipicolinate + NADP+ = 2,3-dihydrodipicolinate + NADPH + H+. IEA GO:0008839 dihydrodipicolinate reductase activity GSVIVG01010618001 15957117 15959551 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: 2,3,4,5-tetrahydrodipicolinate + NADP+ = 2,3-dihydrodipicolinate + NADPH + H+. IEA GO:0008839 dihydrodipicolinate reductase activity GSVIVG01025017001 5239390 5242567 GSVIVG01000113001 15366208 15367076 GSVIVG01025177001 3676334 3687662 GSVIVG01017072001 3965357 3966255 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01017072001 3965357 3966255 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01010557001 16673770 16675604 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010557001 16673770 16675604 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010557001 16673770 16675604 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01010557001 16673770 16675604 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01014833001 10327787 10329303 GSVIVG01006712001 27716380 27718371 GSVIVG01031919001 5404938 5409770 GO:0006464 protein modification process The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031919001 5404938 5409770 GO:0019941 modification-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031919001 5404938 5409770 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031919001 5404938 5409770 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031919001 5404938 5409770 GO:0006464 protein modification process The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01031919001 5404938 5409770 GO:0019941 modification-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01031919001 5404938 5409770 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01031919001 5404938 5409770 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01031919001 5404938 5409770 GO:0006464 protein modification process The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). IEA Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. IEA GO:0016881 acid-amino acid ligase activity GSVIVG01031919001 5404938 5409770 GO:0019941 modification-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein. IEA Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. IEA GO:0016881 acid-amino acid ligase activity GSVIVG01031919001 5404938 5409770 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. IEA GO:0016881 acid-amino acid ligase activity GSVIVG01031919001 5404938 5409770 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. IEA GO:0016881 acid-amino acid ligase activity GSVIVG01031919001 5404938 5409770 GO:0006464 protein modification process The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01031919001 5404938 5409770 GO:0019941 modification-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01031919001 5404938 5409770 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01031919001 5404938 5409770 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01001813001 26018584 26021679 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001813001 26018584 26021679 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate. IEA GO:0019205 nucleobase, nucleoside, nucleotide kinase activity GSVIVG01028407001 7263917 7268334 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01028407001 7263917 7268334 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01031580001 18422990 18423385 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01025251001 2688312 2698626 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01037233001 17086990 17103287 GO:0010024 phytochromobilin biosynthetic process The chemical reactions and pathways resulting in the formation of phytochromobilin, which involves the oxidative cleavage of heme by a heme oxygenase(HO) to form biliverdin IX alpha. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces an iron-sulfur protein. IEA GO:0016636 oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor GSVIVG01037233001 17086990 17103287 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces an iron-sulfur protein. IEA GO:0016636 oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor GSVIVG01037233001 17086990 17103287 GO:0010024 phytochromobilin biosynthetic process The chemical reactions and pathways resulting in the formation of phytochromobilin, which involves the oxidative cleavage of heme by a heme oxygenase(HO) to form biliverdin IX alpha. IEA Interacting selectively and non-covalently with a cobalt (Co) ion. IEA GO:0050897 cobalt ion binding GSVIVG01037233001 17086990 17103287 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a cobalt (Co) ion. IEA GO:0050897 cobalt ion binding GSVIVG01001431001 20920996 20936033 GSVIVG01010243001 18179462 18184021 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01010243001 18179462 18184021 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01004278001 37928065 37931933 GO:0009073 aromatic amino acid family biosynthetic process The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). IEA Catalysis of the reaction: phosphoenolpyruvate + D-erythrose 4-phosphate + H2O = 2-dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + phosphate. IEA GO:0003849 3-deoxy-7-phosphoheptulonate synthase activity GSVIVG01024017001 1726993 1730564 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01011572001 6391853 6397625 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of potassium ions (K+) from one side of a membrane to the other. IEA GO:0015079 potassium ion transmembrane transporter activity GSVIVG01036294001 3445662 3453227 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01036294001 3445662 3453227 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01036294001 3445662 3453227 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01036294001 3445662 3453227 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01036294001 3445662 3453227 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01036294001 3445662 3453227 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01036294001 3445662 3453227 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01036294001 3445662 3453227 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01036294001 3445662 3453227 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036294001 3445662 3453227 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036294001 3445662 3453227 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036294001 3445662 3453227 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036294001 3445662 3453227 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036294001 3445662 3453227 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036294001 3445662 3453227 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036294001 3445662 3453227 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036294001 3445662 3453227 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01036294001 3445662 3453227 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01036294001 3445662 3453227 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01036294001 3445662 3453227 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01021492001 6096911 6109345 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01021492001 6096911 6109345 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01021492001 6096911 6109345 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020461001 19051526 19078587 GO:0006479 protein amino acid methylation The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01020461001 19051526 19078587 GO:0032259 methylation The process by which a methyl group is covalently attached to a molecule. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01020461001 19051526 19078587 GO:0006479 protein amino acid methylation The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01020461001 19051526 19078587 GO:0032259 methylation The process by which a methyl group is covalently attached to a molecule. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01020461001 19051526 19078587 GO:0006479 protein amino acid methylation The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom. IEA Catalysis of the transfer of a methyl group (CH3-) to a protein. IEA GO:0008276 protein methyltransferase activity GSVIVG01020461001 19051526 19078587 GO:0032259 methylation The process by which a methyl group is covalently attached to a molecule. IEA Catalysis of the transfer of a methyl group (CH3-) to a protein. IEA GO:0008276 protein methyltransferase activity GSVIVG01009596001 9737859 9742306 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01009596001 9737859 9742306 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01009596001 9737859 9742306 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01009596001 9737859 9742306 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01013045001 9295261 9321129 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01013045001 9295261 9321129 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01013045001 9295261 9321129 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01013045001 9295261 9321129 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01013045001 9295261 9321129 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01013045001 9295261 9321129 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01013237001 6406803 6414734 Catalysis of the removal of a phosphate group from phosphorylated myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol. IEA GO:0004437 inositol or phosphatidylinositol phosphatase activity GSVIVG01030902001 18722218 18725645 GSVIVG01027860001 8724661 8727638 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01027145001 17436787 17448236 GSVIVG01027323001 16606926 16607794 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01027323001 16606926 16607794 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01035735001 3796710 3800733 GSVIVG01031998001 23674164 23681135 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031998001 23674164 23681135 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031998001 23674164 23681135 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031998001 23674164 23681135 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030473001 5965878 5969987 GSVIVG01022479001 3527773 3534417 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01025318001 2081827 2082237 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01027172001 17260065 17261006 GSVIVG01007817001 8741561 8742409 GSVIVG01018942001 18512510 18514390 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01016742001 855101 866951 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008626001 309494 318858 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033180 proton-transporting V-type ATPase, V1 domain A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01011846001 3675468 3676903 GSVIVG01030351001 8339590 8341007 GSVIVG01038177001 24089120 24092161 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01038177001 24089120 24092161 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01038177001 24089120 24092161 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01038177001 24089120 24092161 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01038177001 24089120 24092161 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01038177001 24089120 24092161 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01038177001 24089120 24092161 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01038177001 24089120 24092161 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01038177001 24089120 24092161 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01038177001 24089120 24092161 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01038177001 24089120 24092161 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01038177001 24089120 24092161 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01038177001 24089120 24092161 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01038177001 24089120 24092161 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01038177001 24089120 24092161 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01019237001 2931227 2945626 GSVIVG01033258001 22099754 22129500 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01033258001 22099754 22129500 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033258001 22099754 22129500 Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01033258001 22099754 22129500 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01015462001 3913694 3916231 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01027604001 15111064 15127142 GO:0006904 vesicle docking involved in exocytosis The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis. IEA GSVIVG01027604001 15111064 15127142 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GSVIVG01002665001 35786844 35790523 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA GSVIVG01011929001 2941266 2946321 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01011929001 2941266 2946321 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01011929001 2941266 2946321 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01033168001 8878295 8882271 GSVIVG01036487001 22609625 22614641 GSVIVG01033329001 21424267 21426648 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01014178001 1247635 1250651 GSVIVG01016764001 1150521 1153564 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01016764001 1150521 1153564 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01000126001 15479833 15483153 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function that links a sequence-specific transcription factor to the core RNA polymerase II complex but does not bind DNA itself. IEA GO:0003712 transcription cofactor activity GSVIVG01000126001 15479833 15483153 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone. IEA GO:0004402 histone acetyltransferase activity GSVIVG01000126001 15479833 15483153 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000126001 15479833 15483153 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008323001 3256478 3260269 GSVIVG01026750001 6220965 6224824 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01026750001 6220965 6224824 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01026750001 6220965 6224824 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026750001 6220965 6224824 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006944001 29208155 29210336 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001047001 7026982 7031966 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01001047001 7026982 7031966 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001047001 7026982 7031966 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01001047001 7026982 7031966 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01025839001 11340473 11353811 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0000502 proteasome complex A large multisubunit complex which catalyzes protein degradation. This complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. IEA GO:0004175 endopeptidase activity GSVIVG01025839001 11340473 11353811 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005839 proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. IEA GO:0004175 endopeptidase activity GSVIVG01025839001 11340473 11353811 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0019773 proteasome core complex, alpha-subunit complex The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. IEA GO:0004175 endopeptidase activity GSVIVG01025839001 11340473 11353811 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0000502 proteasome complex A large multisubunit complex which catalyzes protein degradation. This complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. IEA GO:0004175 endopeptidase activity GSVIVG01025839001 11340473 11353811 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0005839 proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. IEA GO:0004175 endopeptidase activity GSVIVG01025839001 11340473 11353811 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0019773 proteasome core complex, alpha-subunit complex The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. IEA GO:0004175 endopeptidase activity GSVIVG01025839001 11340473 11353811 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0000502 proteasome complex A large multisubunit complex which catalyzes protein degradation. This complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core. IEA Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. IEA GO:0004298 threonine-type endopeptidase activity GSVIVG01025839001 11340473 11353811 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005839 proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. IEA Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. IEA GO:0004298 threonine-type endopeptidase activity GSVIVG01025839001 11340473 11353811 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0019773 proteasome core complex, alpha-subunit complex The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. IEA GO:0004298 threonine-type endopeptidase activity GSVIVG01025839001 11340473 11353811 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0000502 proteasome complex A large multisubunit complex which catalyzes protein degradation. This complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core. IEA Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. IEA GO:0004298 threonine-type endopeptidase activity GSVIVG01025839001 11340473 11353811 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0005839 proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. IEA Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. IEA GO:0004298 threonine-type endopeptidase activity GSVIVG01025839001 11340473 11353811 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0019773 proteasome core complex, alpha-subunit complex The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. IEA GO:0004298 threonine-type endopeptidase activity GSVIVG01025839001 11340473 11353811 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0000502 proteasome complex A large multisubunit complex which catalyzes protein degradation. This complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01025839001 11340473 11353811 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005839 proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01025839001 11340473 11353811 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0019773 proteasome core complex, alpha-subunit complex The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01025839001 11340473 11353811 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0000502 proteasome complex A large multisubunit complex which catalyzes protein degradation. This complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01025839001 11340473 11353811 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0005839 proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01025839001 11340473 11353811 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0019773 proteasome core complex, alpha-subunit complex The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01025839001 11340473 11353811 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0000502 proteasome complex A large multisubunit complex which catalyzes protein degradation. This complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01025839001 11340473 11353811 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005839 proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01025839001 11340473 11353811 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0019773 proteasome core complex, alpha-subunit complex The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01025839001 11340473 11353811 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0000502 proteasome complex A large multisubunit complex which catalyzes protein degradation. This complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01025839001 11340473 11353811 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0005839 proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01025839001 11340473 11353811 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0019773 proteasome core complex, alpha-subunit complex The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01002536001 35246746 35251884 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01002536001 35246746 35251884 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01021474001 5963288 5968899 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01037958001 11550592 11576391 GSVIVG01033003001 25000154 25005976 GSVIVG01033744001 18187600 18188969 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01033744001 18187600 18188969 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01033744001 18187600 18188969 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01033744001 18187600 18188969 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01033744001 18187600 18188969 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01033744001 18187600 18188969 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01033744001 18187600 18188969 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01033744001 18187600 18188969 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01003185001 7700161 7707251 GSVIVG01027197001 17118627 17126330 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01027197001 17118627 17126330 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017003001 3370696 3378447 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01017003001 3370696 3378447 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01017003001 3370696 3378447 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020948001 16650275 16652203 GSVIVG01026856001 19912905 19920442 GSVIVG01000135001 15570755 15574483 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide. IEA GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides GSVIVG01005932001 22822705 22833647 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Prevents the dissociation of GDP from the small GTPase Rab, thereby preventing GTP from binding. IEA GO:0005093 Rab GDP-dissociation inhibitor activity GSVIVG01005932001 22822705 22833647 GO:0043087 regulation of GTPase activity Any process that modulates the rate of GTP hydrolysis by a GTPase. IEA Prevents the dissociation of GDP from the small GTPase Rab, thereby preventing GTP from binding. IEA GO:0005093 Rab GDP-dissociation inhibitor activity GSVIVG01028070001 3584986 3587192 Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01022417001 19916202 19921005 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01022417001 19916202 19921005 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01013745001 7987554 7987940 GSVIVG01025713001 12730204 12736879 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025713001 12730204 12736879 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01010602001 16123091 16126399 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01012531001 682998 744880 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01028300001 5890193 5899068 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01025541001 14188647 14197864 GSVIVG01018770001 20084814 20085182 GSVIVG01006214001 23722745 23722940 GSVIVG01021937001 5381287 5381725 GSVIVG01028111001 3883909 3884088 GSVIVG01026278001 15397472 15397912 GSVIVG01022555001 4909017 4918207 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01022555001 4909017 4918207 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01022555001 4909017 4918207 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport. IEA GO:0051087 chaperone binding GSVIVG01036208001 9026617 9035300 GSVIVG01013283001 5674912 5683893 GSVIVG01027276001 17259881 17263681 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01027276001 17259881 17263681 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01027276001 17259881 17263681 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027276001 17259881 17263681 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017494001 9424610 9434529 GSVIVG01031802001 4481840 4484778 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01031802001 4481840 4484778 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01031802001 4481840 4484778 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01031802001 4481840 4484778 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01031802001 4481840 4484778 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01031802001 4481840 4484778 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01022196001 17363454 17376262 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01009173001 5730103 5742364 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01012837001 5951799 5957323 GO:0030833 regulation of actin filament polymerization Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament. IEA GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA GSVIVG01018088001 6369616 6377812 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01018088001 6369616 6377812 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025377001 1243141 1243263 GSVIVG01009686001 10478268 10480460 GSVIVG01029909001 1320922 1321371 GSVIVG01025914001 27298743 27301524 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01025914001 27298743 27301524 GO:0015948 methanogenesis The chemical reactions and pathways resulting in the formation of methane, a colorless, odorless, flammable gas with the formula CH4. It is the simplest of the alkanes. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01025914001 27298743 27301524 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: 2-(methylthio)ethanesulfonate + N-(7-mercaptoheptanoyl)threonine 3-O-phosphate = CoM-S-S-CoB + methane. 2-(methylthio)ethanesulfonate is also known as methyl-CoM; N-(7-mercaptoheptanoyl)threonine 3-O-phosphate is also known as coenzyme B. IEA GO:0050524 coenzyme-B sulfoethylthiotransferase activity GSVIVG01025914001 27298743 27301524 GO:0015948 methanogenesis The chemical reactions and pathways resulting in the formation of methane, a colorless, odorless, flammable gas with the formula CH4. It is the simplest of the alkanes. IEA Catalysis of the reaction: 2-(methylthio)ethanesulfonate + N-(7-mercaptoheptanoyl)threonine 3-O-phosphate = CoM-S-S-CoB + methane. 2-(methylthio)ethanesulfonate is also known as methyl-CoM; N-(7-mercaptoheptanoyl)threonine 3-O-phosphate is also known as coenzyme B. IEA GO:0050524 coenzyme-B sulfoethylthiotransferase activity GSVIVG01024479001 3111086 3113571 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024479001 3111086 3113571 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024479001 3111086 3113571 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024479001 3111086 3113571 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024479001 3111086 3113571 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024479001 3111086 3113571 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024479001 3111086 3113571 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024479001 3111086 3113571 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024479001 3111086 3113571 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021905001 5790209 5796057 GSVIVG01038032001 16533381 16545164 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01032297001 14746919 14750214 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004185 serine-type carboxypeptidase activity GSVIVG01027561001 15569683 15571391 GO:0006694 steroid biosynthetic process The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01000131001 15521919 15523764 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. IEA GO:0008080 N-acetyltransferase activity GSVIVG01024790001 6932569 6937138 GSVIVG01035391001 953961 957028 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01001409001 18789156 18832323 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004181 metallocarboxypeptidase activity GSVIVG01001409001 18789156 18832323 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01013139001 7767917 7770109 GSVIVG01017471001 8875916 8906100 GSVIVG01008349001 3056031 3059184 GSVIVG01019770001 3184222 3186776 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01019770001 3184222 3186776 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01019770001 3184222 3186776 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01019770001 3184222 3186776 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01019770001 3184222 3186776 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01019770001 3184222 3186776 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient. IEA GO:0005261 cation channel activity GSVIVG01019770001 3184222 3186776 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient. IEA GO:0005261 cation channel activity GSVIVG01019770001 3184222 3186776 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient. IEA GO:0005261 cation channel activity GSVIVG01019770001 3184222 3186776 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient. IEA GO:0005261 cation channel activity GSVIVG01019770001 3184222 3186776 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient. IEA GO:0005261 cation channel activity GSVIVG01019770001 3184222 3186776 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of copper (Cu) ions from one side of a membrane to the other. IEA GO:0005375 copper ion transmembrane transporter activity GSVIVG01019770001 3184222 3186776 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of copper (Cu) ions from one side of a membrane to the other. IEA GO:0005375 copper ion transmembrane transporter activity GSVIVG01019770001 3184222 3186776 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of copper (Cu) ions from one side of a membrane to the other. IEA GO:0005375 copper ion transmembrane transporter activity GSVIVG01019770001 3184222 3186776 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of copper (Cu) ions from one side of a membrane to the other. IEA GO:0005375 copper ion transmembrane transporter activity GSVIVG01019770001 3184222 3186776 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of copper (Cu) ions from one side of a membrane to the other. IEA GO:0005375 copper ion transmembrane transporter activity GSVIVG01019770001 3184222 3186776 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01019770001 3184222 3186776 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01019770001 3184222 3186776 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01019770001 3184222 3186776 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01019770001 3184222 3186776 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01019770001 3184222 3186776 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019770001 3184222 3186776 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019770001 3184222 3186776 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019770001 3184222 3186776 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019770001 3184222 3186776 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019770001 3184222 3186776 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01019770001 3184222 3186776 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01019770001 3184222 3186776 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01019770001 3184222 3186776 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01019770001 3184222 3186776 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01019770001 3184222 3186776 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01019770001 3184222 3186776 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01019770001 3184222 3186776 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01019770001 3184222 3186776 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01019770001 3184222 3186776 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01019770001 3184222 3186776 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01019770001 3184222 3186776 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01019770001 3184222 3186776 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01019770001 3184222 3186776 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01019770001 3184222 3186776 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01005875001 22438120 22441039 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028356001 6519523 6525380 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01025032001 5127199 5135322 Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01005816001 22067040 22071387 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01005816001 22067040 22071387 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01005816001 22067040 22071387 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01035434001 1239834 1246496 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01035434001 1239834 1246496 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01017942001 4912438 4920416 GSVIVG01030646001 7438986 7441486 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01030646001 7438986 7441486 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01004268001 37861661 37862378 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01004268001 37861661 37862378 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01004268001 37861661 37862378 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01004268001 37861661 37862378 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01004268001 37861661 37862378 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01004268001 37861661 37862378 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01004268001 37861661 37862378 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01004268001 37861661 37862378 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031941001 5579524 5580226 GSVIVG01038194001 24253848 24266001 GO:0009405 pathogenesis The set of specific processes that generate the ability of an organism to cause disease in another. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01038194001 24253848 24266001 GO:0016043 cellular component organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cellular component. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01038194001 24253848 24266001 GO:0030036 actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01008721001 1449246 1451159 GSVIVG01030298001 9309573 9313783 GSVIVG01031863001 4981856 4986948 GSVIVG01037481001 12939301 12940125 GSVIVG01008163001 5186803 5186931 GSVIVG01029931001 1634961 1638824 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other. IEA GO:0005337 nucleoside transmembrane transporter activity GSVIVG01029931001 1634961 1638824 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other. IEA GO:0005337 nucleoside transmembrane transporter activity GSVIVG01029931001 1634961 1638824 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other. IEA GO:0005337 nucleoside transmembrane transporter activity GSVIVG01029931001 1634961 1638824 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other. IEA GO:0005337 nucleoside transmembrane transporter activity GSVIVG01029931001 1634961 1638824 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01029931001 1634961 1638824 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01029931001 1634961 1638824 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01029931001 1634961 1638824 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01029931001 1634961 1638824 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01029931001 1634961 1638824 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01029931001 1634961 1638824 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01029931001 1634961 1638824 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01029931001 1634961 1638824 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01029931001 1634961 1638824 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01029931001 1634961 1638824 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01029931001 1634961 1638824 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01008091001 5847140 5857230 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with parathyroid hormone to initiate a change in cell activity. IEA GO:0004991 parathyroid hormone receptor activity GSVIVG01008448001 1919255 1930143 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016629001 2341056 2345397 GO:0006904 vesicle docking involved in exocytosis The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis. IEA GSVIVG01016629001 2341056 2345397 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GSVIVG01012680001 605485 607148 GSVIVG01009753001 10994505 10997621 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01020462001 19037309 19039116 GSVIVG01010368001 19877398 19881935 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01010368001 19877398 19881935 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010368001 19877398 19881935 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01014644001 8137617 8146878 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01036765001 22830808 22834737 GSVIVG01023768001 10817326 10818265 GO:0042773 ATP synthesis coupled electron transport The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP. IEA Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. IEA GO:0008137 NADH dehydrogenase (ubiquinone) activity GSVIVG01023768001 10817326 10818265 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. IEA GO:0008137 NADH dehydrogenase (ubiquinone) activity GSVIVG01010106001 15586831 15619187 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010106001 15586831 15619187 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010106001 15586831 15619187 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010106001 15586831 15619187 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01010106001 15586831 15619187 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01010106001 15586831 15619187 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01010106001 15586831 15619187 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01010106001 15586831 15619187 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01010106001 15586831 15619187 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01010106001 15586831 15619187 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01010106001 15586831 15619187 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01010106001 15586831 15619187 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01013802001 7423321 7426109 GSVIVG01032446001 27493166 27499211 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01032446001 27493166 27499211 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01032446001 27493166 27499211 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01032446001 27493166 27499211 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022089001 16497761 16499328 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01037754001 7546611 7555444 GO:0006071 glycerol metabolic process The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. IEA Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. IEA GO:0008081 phosphoric diester hydrolase activity GSVIVG01037754001 7546611 7555444 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. IEA GO:0008081 phosphoric diester hydrolase activity GSVIVG01037754001 7546611 7555444 GO:0006071 glycerol metabolic process The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. IEA Catalysis of the reaction: a glycerophosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate. IEA GO:0008889 glycerophosphodiester phosphodiesterase activity GSVIVG01037754001 7546611 7555444 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: a glycerophosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate. IEA GO:0008889 glycerophosphodiester phosphodiesterase activity GSVIVG01019333001 943993 946695 GO:0006904 vesicle docking involved in exocytosis The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis. IEA GSVIVG01019333001 943993 946695 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GSVIVG01008567001 823668 827024 GSVIVG01011608001 6018856 6024162 GSVIVG01018226001 12895594 12935971 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01018226001 12895594 12935971 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01018226001 12895594 12935971 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01018226001 12895594 12935971 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01018226001 12895594 12935971 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01018226001 12895594 12935971 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01018226001 12895594 12935971 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01018226001 12895594 12935971 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01020352001 20911181 20912549 GSVIVG01010742001 22024944 22037763 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01010742001 22024944 22037763 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01010742001 22024944 22037763 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01021261001 3113133 3118051 GSVIVG01009902001 12275798 12276616 GSVIVG01022346001 18781499 18783615 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01022346001 18781499 18783615 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01022346001 18781499 18783615 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01022346001 18781499 18783615 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01022346001 18781499 18783615 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022346001 18781499 18783615 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022346001 18781499 18783615 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01022346001 18781499 18783615 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01022346001 18781499 18783615 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01022346001 18781499 18783615 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01022346001 18781499 18783615 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01022346001 18781499 18783615 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01022346001 18781499 18783615 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01022346001 18781499 18783615 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01001894001 6890504 6891822 GSVIVG01013983001 8412252 8422286 GO:0006414 translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01013983001 8412252 8422286 GO:0006414 translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01019632001 2102063 2102771 GSVIVG01002585001 35319080 35319650 GSVIVG01022028001 4147806 4148926 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01030642001 7374750 7377610 GO:0000272 polysaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030642001 7374750 7377610 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030642001 7374750 7377610 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030642001 7374750 7377610 GO:0000272 polysaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages. IEA Catalysis of the hydrolysis of 1,4-alpha-glucosidic linkages in polysaccharides so as to remove successive maltose units from the non-reducing ends of the chains. IEA GO:0016161 beta-amylase activity GSVIVG01030642001 7374750 7377610 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of 1,4-alpha-glucosidic linkages in polysaccharides so as to remove successive maltose units from the non-reducing ends of the chains. IEA GO:0016161 beta-amylase activity GSVIVG01030642001 7374750 7377610 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of 1,4-alpha-glucosidic linkages in polysaccharides so as to remove successive maltose units from the non-reducing ends of the chains. IEA GO:0016161 beta-amylase activity GSVIVG01030642001 7374750 7377610 GO:0000272 polysaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01030642001 7374750 7377610 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01030642001 7374750 7377610 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01030642001 7374750 7377610 GO:0000272 polysaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01030642001 7374750 7377610 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01030642001 7374750 7377610 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01030642001 7374750 7377610 GO:0000272 polysaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01030642001 7374750 7377610 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01030642001 7374750 7377610 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01030172001 10852165 10862948 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01030172001 10852165 10862948 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01030172001 10852165 10862948 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01030172001 10852165 10862948 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01030172001 10852165 10862948 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01030172001 10852165 10862948 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01030172001 10852165 10862948 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030172001 10852165 10862948 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030172001 10852165 10862948 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030172001 10852165 10862948 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030172001 10852165 10862948 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030172001 10852165 10862948 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030172001 10852165 10862948 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the movement of phospholipids from one membrane face to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP. IEA GO:0004012 phospholipid-translocating ATPase activity GSVIVG01030172001 10852165 10862948 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the movement of phospholipids from one membrane face to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP. IEA GO:0004012 phospholipid-translocating ATPase activity GSVIVG01030172001 10852165 10862948 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the movement of phospholipids from one membrane face to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP. IEA GO:0004012 phospholipid-translocating ATPase activity GSVIVG01030172001 10852165 10862948 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the movement of phospholipids from one membrane face to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP. IEA GO:0004012 phospholipid-translocating ATPase activity GSVIVG01030172001 10852165 10862948 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the movement of phospholipids from one membrane face to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP. IEA GO:0004012 phospholipid-translocating ATPase activity GSVIVG01030172001 10852165 10862948 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the movement of phospholipids from one membrane face to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP. IEA GO:0004012 phospholipid-translocating ATPase activity GSVIVG01030172001 10852165 10862948 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030172001 10852165 10862948 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030172001 10852165 10862948 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030172001 10852165 10862948 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030172001 10852165 10862948 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030172001 10852165 10862948 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030172001 10852165 10862948 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01030172001 10852165 10862948 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01030172001 10852165 10862948 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01030172001 10852165 10862948 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01030172001 10852165 10862948 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01030172001 10852165 10862948 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01011082001 1745199 1748254 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01011082001 1745199 1748254 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01011082001 1745199 1748254 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01011082001 1745199 1748254 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01011082001 1745199 1748254 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01011082001 1745199 1748254 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01007731001 9841308 9843240 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01029517001 22026495 22027067 GSVIVG01015405001 3329912 3336866 GSVIVG01017443001 8569080 8603866 GO:0006571 tyrosine biosynthetic process The chemical reactions and pathways resulting in the formation of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01017443001 8569080 8603866 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01017443001 8569080 8603866 GO:0006571 tyrosine biosynthetic process The chemical reactions and pathways resulting in the formation of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid. IEA Catalysis of the reaction: prephenate + NADP+ = 4-hydroxyphenylpyruvate + CO2 + NADPH + H+. IEA GO:0004665 prephenate dehydrogenase (NADP+) activity GSVIVG01017443001 8569080 8603866 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: prephenate + NADP+ = 4-hydroxyphenylpyruvate + CO2 + NADPH + H+. IEA GO:0004665 prephenate dehydrogenase (NADP+) activity GSVIVG01017443001 8569080 8603866 GO:0006571 tyrosine biosynthetic process The chemical reactions and pathways resulting in the formation of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017443001 8569080 8603866 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017443001 8569080 8603866 GO:0006571 tyrosine biosynthetic process The chemical reactions and pathways resulting in the formation of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01017443001 8569080 8603866 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01017443001 8569080 8603866 GO:0006571 tyrosine biosynthetic process The chemical reactions and pathways resulting in the formation of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid. IEA Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. IEA GO:0048037 cofactor binding GSVIVG01017443001 8569080 8603866 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. IEA GO:0048037 cofactor binding GSVIVG01031085001 2497942 2498956 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with manganese (Mn) ions. IEA GO:0030145 manganese ion binding GSVIVG01031085001 2497942 2498956 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Functions in the storage of nutritious substrates. IEA GO:0045735 nutrient reservoir activity GSVIVG01031085001 2497942 2498956 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01034258001 13607556 13608077 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01034228001 13063468 13094183 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01014771001 9482389 9486598 GSVIVG01032091001 22800162 22807290 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01032091001 22800162 22807290 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01032091001 22800162 22807290 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01032091001 22800162 22807290 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01030227001 10247135 10250424 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030227001 10247135 10250424 Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. IEA GO:0008483 transaminase activity GSVIVG01030227001 10247135 10250424 Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01012695001 734300 738480 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01028643001 11478855 11487512 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01028643001 11478855 11487512 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01027677001 14434770 14447192 GSVIVG01026173001 13406903 13407626 GSVIVG01010844001 23307090 23315437 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010844001 23307090 23315437 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010844001 23307090 23315437 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01010844001 23307090 23315437 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01010844001 23307090 23315437 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01010844001 23307090 23315437 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01011849001 3628671 3638222 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01011849001 3628671 3638222 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01011849001 3628671 3638222 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01011849001 3628671 3638222 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009500001 8878221 8883483 GSVIVG01038044001 16803108 16803919 GSVIVG01032906001 23981543 23982426 GSVIVG01022808001 16853297 16878858 GO:0016043 cellular component organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cellular component. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01022808001 16853297 16878858 GO:0030036 actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01014355001 2952976 2954565 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01014355001 2952976 2954565 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01014355001 2952976 2954565 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01018414001 9408151 9408501 GSVIVG01002718001 36058491 36059262 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01014847001 10527535 10529868 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01014847001 10527535 10529868 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01014847001 10527535 10529868 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01014847001 10527535 10529868 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01014847001 10527535 10529868 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01014847001 10527535 10529868 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01014847001 10527535 10529868 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01014847001 10527535 10529868 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01014847001 10527535 10529868 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014847001 10527535 10529868 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014847001 10527535 10529868 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014847001 10527535 10529868 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014847001 10527535 10529868 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01014847001 10527535 10529868 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01014847001 10527535 10529868 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01014847001 10527535 10529868 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01023072001 15849887 15866624 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023072001 15849887 15866624 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023072001 15849887 15866624 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01023072001 15849887 15866624 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01023072001 15849887 15866624 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023072001 15849887 15866624 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034754001 9023618 9028953 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003226001 14198851 14219965 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01007674001 10603919 10605601 GSVIVG01037910001 6406134 6406946 GSVIVG01011795001 4091418 4094089 GSVIVG01014546001 5018415 5018620 GSVIVG01025397001 1094444 1095244 GSVIVG01004413001 38460620 38463187 GSVIVG01019827001 3679351 3708506 GSVIVG01013712001 8304390 8331824 GO:0006467 protein thiol-disulfide exchange Oxidation of two organic sulfhydryl groups (thiols) by a disulfide compound to form a disulfide bond. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013712001 8304390 8331824 GO:0006467 protein thiol-disulfide exchange Oxidation of two organic sulfhydryl groups (thiols) by a disulfide compound to form a disulfide bond. IEA GO:0005789 endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013712001 8304390 8331824 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013712001 8304390 8331824 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005789 endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013712001 8304390 8331824 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013712001 8304390 8331824 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005789 endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013712001 8304390 8331824 GO:0006467 protein thiol-disulfide exchange Oxidation of two organic sulfhydryl groups (thiols) by a disulfide compound to form a disulfide bond. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01013712001 8304390 8331824 GO:0006467 protein thiol-disulfide exchange Oxidation of two organic sulfhydryl groups (thiols) by a disulfide compound to form a disulfide bond. IEA GO:0005789 endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01013712001 8304390 8331824 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01013712001 8304390 8331824 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005789 endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01013712001 8304390 8331824 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01013712001 8304390 8331824 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005789 endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01013712001 8304390 8331824 GO:0006467 protein thiol-disulfide exchange Oxidation of two organic sulfhydryl groups (thiols) by a disulfide compound to form a disulfide bond. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide. IEA GO:0016671 oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor GSVIVG01013712001 8304390 8331824 GO:0006467 protein thiol-disulfide exchange Oxidation of two organic sulfhydryl groups (thiols) by a disulfide compound to form a disulfide bond. IEA GO:0005789 endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum. IEA Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide. IEA GO:0016671 oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor GSVIVG01013712001 8304390 8331824 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide. IEA GO:0016671 oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor GSVIVG01013712001 8304390 8331824 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005789 endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum. IEA Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide. IEA GO:0016671 oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor GSVIVG01013712001 8304390 8331824 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide. IEA GO:0016671 oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor GSVIVG01013712001 8304390 8331824 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005789 endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum. IEA Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide. IEA GO:0016671 oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor GSVIVG01013712001 8304390 8331824 GO:0006467 protein thiol-disulfide exchange Oxidation of two organic sulfhydryl groups (thiols) by a disulfide compound to form a disulfide bond. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01013712001 8304390 8331824 GO:0006467 protein thiol-disulfide exchange Oxidation of two organic sulfhydryl groups (thiols) by a disulfide compound to form a disulfide bond. IEA GO:0005789 endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01013712001 8304390 8331824 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01013712001 8304390 8331824 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005789 endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01013712001 8304390 8331824 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01013712001 8304390 8331824 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005789 endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01015827001 17971906 17975776 GO:0000027 ribosomal large subunit assembly The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01015827001 17971906 17975776 GO:0000027 ribosomal large subunit assembly The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01015827001 17971906 17975776 GO:0000027 ribosomal large subunit assembly The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01015827001 17971906 17975776 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01015827001 17971906 17975776 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01015827001 17971906 17975776 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01015827001 17971906 17975776 GO:0000027 ribosomal large subunit assembly The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01015827001 17971906 17975776 GO:0000027 ribosomal large subunit assembly The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01015827001 17971906 17975776 GO:0000027 ribosomal large subunit assembly The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01015827001 17971906 17975776 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01015827001 17971906 17975776 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01015827001 17971906 17975776 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01015827001 17971906 17975776 GO:0000027 ribosomal large subunit assembly The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ribosomal RNA. IEA GO:0019843 rRNA binding GSVIVG01015827001 17971906 17975776 GO:0000027 ribosomal large subunit assembly The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with ribosomal RNA. IEA GO:0019843 rRNA binding GSVIVG01015827001 17971906 17975776 GO:0000027 ribosomal large subunit assembly The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA Interacting selectively and non-covalently with ribosomal RNA. IEA GO:0019843 rRNA binding GSVIVG01015827001 17971906 17975776 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ribosomal RNA. IEA GO:0019843 rRNA binding GSVIVG01015827001 17971906 17975776 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with ribosomal RNA. IEA GO:0019843 rRNA binding GSVIVG01015827001 17971906 17975776 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA Interacting selectively and non-covalently with ribosomal RNA. IEA GO:0019843 rRNA binding GSVIVG01009573001 9524348 9539866 GO:0000226 microtubule cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. IEA GO:0000922 spindle pole Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules. IEA GSVIVG01009573001 9524348 9539866 GO:0000226 microtubule cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. IEA GO:0005815 microtubule organizing center A cytoplasmic structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides. IEA GSVIVG01021869001 6243402 6244495 GSVIVG01028983001 16909806 16910663 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01028983001 16909806 16910663 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01018120001 6714620 6724790 GSVIVG01006883001 28878383 28880400 GO:0006278 RNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01006883001 28878383 28880400 GO:0006278 RNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. IEA Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time. IEA GO:0003964 RNA-directed DNA polymerase activity GSVIVG01001215001 729723 730897 GSVIVG01009523001 9046770 9060635 GSVIVG01036483001 22568746 22570780 GO:0006537 glutamate biosynthetic process The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid. IEA Catalysis of the reaction: L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor. IEA GO:0004657 proline dehydrogenase activity GSVIVG01036483001 22568746 22570780 GO:0006562 proline catabolic process The chemical reactions and pathways resulting in the breakdown of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins. IEA Catalysis of the reaction: L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor. IEA GO:0004657 proline dehydrogenase activity GSVIVG01036483001 22568746 22570780 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor. IEA GO:0004657 proline dehydrogenase activity GSVIVG01015344001 2835900 2836310 GSVIVG01011094001 1639779 1659963 GSVIVG01014594001 5422994 5430258 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036822001 17510947 17512912 GSVIVG01023196001 21239402 21251693 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01023196001 21239402 21251693 GO:0016570 histone modification The covalent alteration of one or more amino acid residues within a histone protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01033695001 18571540 18577487 GSVIVG01026691001 4875339 4876314 GSVIVG01025470001 562475 583468 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004197 cysteine-type endopeptidase activity GSVIVG01025470001 562475 583468 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium. IEA GO:0004198 calcium-dependent cysteine-type endopeptidase activity GSVIVG01023982001 1933536 1941032 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01023982001 1933536 1941032 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01023982001 1933536 1941032 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0033180 proton-transporting V-type ATPase, V1 domain A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01023982001 1933536 1941032 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01023982001 1933536 1941032 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01023982001 1933536 1941032 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033180 proton-transporting V-type ATPase, V1 domain A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01023982001 1933536 1941032 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01023982001 1933536 1941032 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01023982001 1933536 1941032 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033180 proton-transporting V-type ATPase, V1 domain A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01023982001 1933536 1941032 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01023982001 1933536 1941032 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01023982001 1933536 1941032 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033180 proton-transporting V-type ATPase, V1 domain A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01023982001 1933536 1941032 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01023982001 1933536 1941032 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01023982001 1933536 1941032 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0033180 proton-transporting V-type ATPase, V1 domain A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01023982001 1933536 1941032 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01023982001 1933536 1941032 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01023982001 1933536 1941032 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0033180 proton-transporting V-type ATPase, V1 domain A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01023982001 1933536 1941032 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01023982001 1933536 1941032 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01023982001 1933536 1941032 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033180 proton-transporting V-type ATPase, V1 domain A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01023982001 1933536 1941032 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01023982001 1933536 1941032 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01023982001 1933536 1941032 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033180 proton-transporting V-type ATPase, V1 domain A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01023982001 1933536 1941032 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01023982001 1933536 1941032 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01023982001 1933536 1941032 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033180 proton-transporting V-type ATPase, V1 domain A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01023982001 1933536 1941032 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01023982001 1933536 1941032 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01023982001 1933536 1941032 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0033180 proton-transporting V-type ATPase, V1 domain A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01023982001 1933536 1941032 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01023982001 1933536 1941032 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01023982001 1933536 1941032 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0033180 proton-transporting V-type ATPase, V1 domain A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01023982001 1933536 1941032 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01023982001 1933536 1941032 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01023982001 1933536 1941032 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033180 proton-transporting V-type ATPase, V1 domain A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01023982001 1933536 1941032 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01023982001 1933536 1941032 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01023982001 1933536 1941032 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033180 proton-transporting V-type ATPase, V1 domain A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01023982001 1933536 1941032 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01023982001 1933536 1941032 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01023982001 1933536 1941032 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033180 proton-transporting V-type ATPase, V1 domain A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01023982001 1933536 1941032 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01023982001 1933536 1941032 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01023982001 1933536 1941032 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0033180 proton-transporting V-type ATPase, V1 domain A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01001698001 12208528 12209070 GSVIVG01029357001 15172309 15173997 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029357001 15172309 15173997 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029357001 15172309 15173997 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01029357001 15172309 15173997 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01029357001 15172309 15173997 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01029357001 15172309 15173997 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01027485001 16412309 16417720 GSVIVG01009901001 12262592 12268254 GO:0016068 type I hypersensitivity An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells or basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines. IEA GSVIVG01033368001 21172463 21178634 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01033368001 21172463 21178634 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01033368001 21172463 21178634 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01033368001 21172463 21178634 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01022178001 17231237 17231536 GSVIVG01032056001 23143215 23151838 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01032056001 23143215 23151838 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01005281001 435944 438874 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01005281001 435944 438874 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01005281001 435944 438874 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01005281001 435944 438874 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01005281001 435944 438874 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01005281001 435944 438874 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01005281001 435944 438874 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01005281001 435944 438874 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01005281001 435944 438874 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01005281001 435944 438874 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01005281001 435944 438874 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01005281001 435944 438874 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01005281001 435944 438874 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01005281001 435944 438874 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01005281001 435944 438874 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01005281001 435944 438874 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01005281001 435944 438874 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01005281001 435944 438874 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01005281001 435944 438874 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01005281001 435944 438874 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01023349001 19452793 19453536 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01023349001 19452793 19453536 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01023349001 19452793 19453536 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030638001 7351737 7353178 GSVIVG01029028001 10923365 10923571 GSVIVG01001578001 5498909 5500056 GSVIVG01021906001 5789868 5790158 GSVIVG01031879001 5071224 5110910 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031879001 5071224 5110910 Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01033627001 19124125 19127680 GSVIVG01033116001 25868155 25875883 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01028587001 10269947 10272140 GSVIVG01022023001 4176644 4185717 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01022023001 4176644 4185717 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01022023001 4176644 4185717 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01022023001 4176644 4185717 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01013781001 7666013 7675484 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01034082001 15306886 15313666 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01034082001 15306886 15313666 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01034082001 15306886 15313666 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034082001 15306886 15313666 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01021283001 3417144 3422443 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01021283001 3417144 3422443 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01021283001 3417144 3422443 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01021283001 3417144 3422443 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024461001 2914546 2914665 GSVIVG01012710001 872795 876237 Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01029204001 18578712 18581092 GSVIVG01035142001 1806220 1809826 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035142001 1806220 1809826 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035142001 1806220 1809826 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035142001 1806220 1809826 GO:0045226 extracellular polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035142001 1806220 1809826 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035142001 1806220 1809826 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035142001 1806220 1809826 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035142001 1806220 1809826 GO:0045226 extracellular polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035142001 1806220 1809826 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + NADPH + H+. IEA GO:0008831 dTDP-4-dehydrorhamnose reductase activity GSVIVG01035142001 1806220 1809826 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + NADPH + H+. IEA GO:0008831 dTDP-4-dehydrorhamnose reductase activity GSVIVG01035142001 1806220 1809826 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + NADPH + H+. IEA GO:0008831 dTDP-4-dehydrorhamnose reductase activity GSVIVG01035142001 1806220 1809826 GO:0045226 extracellular polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. IEA Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + NADPH + H+. IEA GO:0008831 dTDP-4-dehydrorhamnose reductase activity GSVIVG01035142001 1806220 1809826 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. IEA GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GSVIVG01035142001 1806220 1809826 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. IEA GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GSVIVG01035142001 1806220 1809826 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. IEA GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GSVIVG01035142001 1806220 1809826 GO:0045226 extracellular polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. IEA Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. IEA GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GSVIVG01035142001 1806220 1809826 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01035142001 1806220 1809826 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01035142001 1806220 1809826 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01035142001 1806220 1809826 GO:0045226 extracellular polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01028844001 18132221 18133994 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01007666001 10707719 10708704 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01007666001 10707719 10708704 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01007666001 10707719 10708704 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001839001 26211792 26215896 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01032100001 22708682 22716415 GSVIVG01020931001 16958916 16960436 GSVIVG01038405001 11837261 11838744 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01036092001 20767241 20770070 GSVIVG01006306001 24772004 24774854 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01006306001 24772004 24774854 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01006306001 24772004 24774854 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01006306001 24772004 24774854 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01006306001 24772004 24774854 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01006306001 24772004 24774854 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01006306001 24772004 24774854 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01006306001 24772004 24774854 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01014386001 3286083 3287727 GSVIVG01025672001 13040771 13054948 GSVIVG01011942001 2781375 2783587 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01011942001 2781375 2783587 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01011942001 2781375 2783587 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01011942001 2781375 2783587 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01011942001 2781375 2783587 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01011942001 2781375 2783587 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01032660001 1738803 1742125 GSVIVG01034058001 15495074 15496199 GSVIVG01003537001 195583 205686 GSVIVG01033488001 20308555 20318722 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033488001 20308555 20318722 Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01033301001 21681158 21706396 GSVIVG01015193001 1695480 1702000 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01020013001 11585230 11597948 GSVIVG01029653001 20186838 20187254 GSVIVG01004401001 38387191 38390496 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01004401001 38387191 38390496 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01020663001 3301694 3325721 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01027660001 14547525 14550931 GSVIVG01033236001 22326359 22332740 GSVIVG01015997001 17100874 17124562 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01015997001 17100874 17124562 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01033425001 20821413 20826148 GO:0006413 translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. IEA GO:0005852 eukaryotic translation initiation factor 3 complex A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs. IEA Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. IEA GO:0003743 translation initiation factor activity GSVIVG01011704001 4934360 4949025 GO:0048268 clathrin coat assembly The process by which clathrin triskelia are assembled into the ordered structure known as a clathrin cage. IEA GO:0030118 clathrin coat A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes. IEA Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester. IEA GO:0005543 phospholipid binding GSVIVG01011704001 4934360 4949025 GO:0048268 clathrin coat assembly The process by which clathrin triskelia are assembled into the ordered structure known as a clathrin cage. IEA GO:0030118 clathrin coat A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes. IEA Interacting selectively and non-covalently with phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. IEA GO:0005545 phosphatidylinositol binding GSVIVG01011704001 4934360 4949025 GO:0048268 clathrin coat assembly The process by which clathrin triskelia are assembled into the ordered structure known as a clathrin cage. IEA GO:0030118 clathrin coat A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes. IEA Interacting selectively and non-covalently with a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles. IEA GO:0030276 clathrin binding GSVIVG01037585001 10566868 10568112 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01037585001 10566868 10568112 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01021777001 10947868 10951290 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01021777001 10947868 10951290 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01021777001 10947868 10951290 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01021777001 10947868 10951290 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01021777001 10947868 10951290 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036146001 20106525 20156686 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: bile acid(out) + Na+(out) = bile acid(in) + Na+(in). IEA GO:0008508 bile acid:sodium symporter activity GSVIVG01037625001 6327724 6329625 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01037625001 6327724 6329625 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01037625001 6327724 6329625 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01037625001 6327724 6329625 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01034993001 753418 753947 GSVIVG01022155001 17046477 17053561 GSVIVG01015589001 5284529 5286376 GSVIVG01037776001 7769886 7772078 GSVIVG01020874001 733797 735398 GSVIVG01015374001 3107842 3108617 GSVIVG01037103001 29107956 29111539 GSVIVG01026884001 19658788 19659354 GSVIVG01020230001 8821976 8823836 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01020230001 8821976 8823836 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01020230001 8821976 8823836 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01020230001 8821976 8823836 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013871001 5714744 5715529 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01013871001 5714744 5715529 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01013871001 5714744 5715529 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01010416001 20363959 20365455 GSVIVG01017905001 4515440 4529233 GO:0006464 protein modification process The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01017905001 4515440 4529233 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01017905001 4515440 4529233 GO:0045116 protein neddylation Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01017905001 4515440 4529233 GO:0006464 protein modification process The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017905001 4515440 4529233 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017905001 4515440 4529233 GO:0045116 protein neddylation Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017905001 4515440 4529233 GO:0006464 protein modification process The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017905001 4515440 4529233 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017905001 4515440 4529233 GO:0045116 protein neddylation Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017905001 4515440 4529233 GO:0006464 protein modification process The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). IEA Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond. IEA GO:0008641 small protein activating enzyme activity GSVIVG01017905001 4515440 4529233 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond. IEA GO:0008641 small protein activating enzyme activity GSVIVG01017905001 4515440 4529233 GO:0045116 protein neddylation Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein. IEA Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond. IEA GO:0008641 small protein activating enzyme activity GSVIVG01017905001 4515440 4529233 GO:0006464 protein modification process The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). IEA Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. IEA GO:0016881 acid-amino acid ligase activity GSVIVG01017905001 4515440 4529233 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. IEA GO:0016881 acid-amino acid ligase activity GSVIVG01017905001 4515440 4529233 GO:0045116 protein neddylation Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein. IEA Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. IEA GO:0016881 acid-amino acid ligase activity GSVIVG01018422001 9230405 9259328 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01018422001 9230405 9259328 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01018422001 9230405 9259328 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01018422001 9230405 9259328 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01038755001 499075 507645 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01038755001 499075 507645 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01038755001 499075 507645 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01038755001 499075 507645 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01038755001 499075 507645 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01038755001 499075 507645 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01038755001 499075 507645 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01038755001 499075 507645 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01038755001 499075 507645 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01038755001 499075 507645 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01038755001 499075 507645 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01038755001 499075 507645 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01038755001 499075 507645 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038755001 499075 507645 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038755001 499075 507645 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038755001 499075 507645 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038755001 499075 507645 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01038755001 499075 507645 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01038755001 499075 507645 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01038755001 499075 507645 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01038755001 499075 507645 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01038755001 499075 507645 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01038755001 499075 507645 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01038755001 499075 507645 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01027300001 16950327 16950908 GSVIVG01025458001 690881 691012 GSVIVG01001159001 1182009 1182934 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009538 photosystem I reaction center A photochemical system containing P700, the chlorophyll a dimer that functions as a primary electron donor. Functioning as a light-dependent plastocyanin-ferredoxin oxidoreductase, it transfers electrons from plastocyanin to ferredoxin. IEA GSVIVG01007873001 8111068 8115895 GSVIVG01017528001 9958977 9959979 GSVIVG01028337001 6272320 6274256 Functions in the storage of nutritious substrates. IEA GO:0045735 nutrient reservoir activity GSVIVG01023156001 21812589 21820136 GO:0006821 chloride transport The directed movement of chloride into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01023156001 21812589 21820136 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01023156001 21812589 21820136 GO:0006821 chloride transport The directed movement of chloride into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a chloride ion by a voltage-gated channel. IEA GO:0005247 voltage-gated chloride channel activity GSVIVG01023156001 21812589 21820136 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a chloride ion by a voltage-gated channel. IEA GO:0005247 voltage-gated chloride channel activity GSVIVG01026574001 21549233 21550687 GSVIVG01015377001 3123889 3129003 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0008236 serine-type peptidase activity GSVIVG01015377001 3123889 3129003 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0008236 serine-type peptidase activity GSVIVG01030479001 6010761 6014129 GSVIVG01004803001 28218 33962 GSVIVG01002466001 34910641 34911544 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01002466001 34910641 34911544 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01002466001 34910641 34911544 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01002466001 34910641 34911544 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01013241001 6378168 6384034 GO:0009116 nucleoside metabolic process The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine). IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01013241001 6378168 6384034 GO:0009156 ribonucleoside monophosphate biosynthetic process The chemical reactions and pathways resulting in the formation of a ribonucleoside monophosphate, a glycosamine consisting of a base linked to a ribose sugar esterified with phosphate on its glycose moiety. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01013241001 6378168 6384034 GO:0009165 nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates). IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01013241001 6378168 6384034 GO:0044249 cellular biosynthetic process The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01013241001 6378168 6384034 GO:0009116 nucleoside metabolic process The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine). IEA Catalysis of the reaction: ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate. IEA GO:0004749 ribose phosphate diphosphokinase activity GSVIVG01013241001 6378168 6384034 GO:0009156 ribonucleoside monophosphate biosynthetic process The chemical reactions and pathways resulting in the formation of a ribonucleoside monophosphate, a glycosamine consisting of a base linked to a ribose sugar esterified with phosphate on its glycose moiety. IEA Catalysis of the reaction: ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate. IEA GO:0004749 ribose phosphate diphosphokinase activity GSVIVG01013241001 6378168 6384034 GO:0009165 nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates). IEA Catalysis of the reaction: ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate. IEA GO:0004749 ribose phosphate diphosphokinase activity GSVIVG01013241001 6378168 6384034 GO:0044249 cellular biosynthetic process The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. IEA Catalysis of the reaction: ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate. IEA GO:0004749 ribose phosphate diphosphokinase activity GSVIVG01013241001 6378168 6384034 GO:0009116 nucleoside metabolic process The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine). IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01013241001 6378168 6384034 GO:0009156 ribonucleoside monophosphate biosynthetic process The chemical reactions and pathways resulting in the formation of a ribonucleoside monophosphate, a glycosamine consisting of a base linked to a ribose sugar esterified with phosphate on its glycose moiety. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01013241001 6378168 6384034 GO:0009165 nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates). IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01013241001 6378168 6384034 GO:0044249 cellular biosynthetic process The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01013241001 6378168 6384034 GO:0009116 nucleoside metabolic process The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine). IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01013241001 6378168 6384034 GO:0009156 ribonucleoside monophosphate biosynthetic process The chemical reactions and pathways resulting in the formation of a ribonucleoside monophosphate, a glycosamine consisting of a base linked to a ribose sugar esterified with phosphate on its glycose moiety. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01013241001 6378168 6384034 GO:0009165 nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates). IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01013241001 6378168 6384034 GO:0044249 cellular biosynthetic process The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01022429001 2798984 2799395 GO:0006397 mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA GSVIVG01037688001 6895977 6896401 GSVIVG01035210001 10519232 10523018 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: UDP-glucose + D-fructose = UDP + sucrose. IEA GO:0016157 sucrose synthase activity GSVIVG01013440001 444050 446447 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01013440001 444050 446447 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01013440001 444050 446447 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01013440001 444050 446447 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019030001 17573396 17575463 GSVIVG01025705001 12814051 12814647 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025705001 12814051 12814647 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025705001 12814051 12814647 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025705001 12814051 12814647 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025705001 12814051 12814647 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01025705001 12814051 12814647 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01002340001 34206697 34217510 GSVIVG01020930001 16964101 16966907 GSVIVG01018556001 13411714 13413441 GSVIVG01014201001 1420720 1420884 GSVIVG01017932001 4804236 4828082 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003144001 6263542 6270080 GSVIVG01013304001 11474365 11477356 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01013304001 11474365 11477356 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01011108001 1506770 1516786 GSVIVG01033252001 22170222 22180715 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01033252001 22170222 22180715 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038582001 21733933 21737609 Interacting selectively and non-covalently with acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group. IEA GO:0000062 acyl-CoA binding GSVIVG01038582001 21733933 21737609 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01022273001 18072957 18074229 GSVIVG01013923001 6847616 6850269 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01013923001 6847616 6850269 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01036223001 8753538 8756300 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01036223001 8753538 8756300 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01001867001 292429 298664 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion. IEA GO:0004806 triglyceride lipase activity GSVIVG01018785001 19853974 19859314 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018785001 19853974 19859314 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018785001 19853974 19859314 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01018785001 19853974 19859314 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01037685001 6870994 6878047 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005764 lysosome A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01037685001 6870994 6878047 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA GO:0005764 lysosome A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01037685001 6870994 6878047 GO:0006665 sphingolipid metabolic process The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). IEA GO:0005764 lysosome A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01029840001 321192 325444 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01029840001 321192 325444 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029840001 321192 325444 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the reaction: ATP + pyruvate = ADP + phosphoenolpyruvate. IEA GO:0004743 pyruvate kinase activity GSVIVG01029840001 321192 325444 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Interacting selectively and non-covalently with potassium (K+) ions. IEA GO:0030955 potassium ion binding GSVIVG01027655001 14588962 14608662 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain. IEA GO:0004177 aminopeptidase activity GSVIVG01027655001 14588962 14608662 GO:0009987 cellular process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. IEA Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain. IEA GO:0004177 aminopeptidase activity GSVIVG01027655001 14588962 14608662 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008235 metalloexopeptidase activity GSVIVG01027655001 14588962 14608662 GO:0009987 cellular process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008235 metalloexopeptidase activity GSVIVG01026428001 23691921 23692702 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01021565001 7138898 7140061 GSVIVG01011627001 5781886 5784954 GSVIVG01017880001 4262620 4264704 GSVIVG01021793001 7308129 7311886 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021793001 7308129 7311886 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021793001 7308129 7311886 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021793001 7308129 7311886 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01021793001 7308129 7311886 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01021793001 7308129 7311886 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01021793001 7308129 7311886 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. IEA GO:0016853 isomerase activity GSVIVG01021793001 7308129 7311886 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. IEA GO:0016853 isomerase activity GSVIVG01021793001 7308129 7311886 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. IEA GO:0016853 isomerase activity GSVIVG01021793001 7308129 7311886 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. IEA GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GSVIVG01021793001 7308129 7311886 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. IEA GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GSVIVG01021793001 7308129 7311886 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. IEA GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GSVIVG01021793001 7308129 7311886 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: GDP-mannose = GDP-L-galactose. IEA GO:0047918 GDP-mannose 3,5-epimerase activity GSVIVG01021793001 7308129 7311886 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: GDP-mannose = GDP-L-galactose. IEA GO:0047918 GDP-mannose 3,5-epimerase activity GSVIVG01021793001 7308129 7311886 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of the reaction: GDP-mannose = GDP-L-galactose. IEA GO:0047918 GDP-mannose 3,5-epimerase activity GSVIVG01021793001 7308129 7311886 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01021793001 7308129 7311886 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01021793001 7308129 7311886 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01028439001 7530672 7535182 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01027347001 16080429 16082642 GSVIVG01009760001 11043669 11050016 GSVIVG01023814001 3270357 3273742 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01032368001 26768061 26777284 GSVIVG01020205001 9083835 9085818 GSVIVG01038204001 24329608 24332273 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01038204001 24329608 24332273 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01038204001 24329608 24332273 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01033950001 16398020 16406169 GO:0006887 exocytosis A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell. This is the process whereby most molecules are secreted from eukaryotic cells. IEA GO:0000145 exocyst A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals. IEA GSVIVG01026077001 24889179 24892076 GSVIVG01008271001 3763195 3764950 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01012632001 222774 228777 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01012632001 222774 228777 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01012632001 222774 228777 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01012632001 222774 228777 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015376001 3121899 3123882 GSVIVG01021946001 5289959 5292533 GSVIVG01026827001 20140716 20143267 GSVIVG01008196001 4784645 4791492 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: cysteamine + O2 = hypotaurine. IEA GO:0047800 cysteamine dioxygenase activity GSVIVG01029957001 2197337 2198134 GSVIVG01017862001 4112285 4113778 GSVIVG01008857001 2861113 2864726 GSVIVG01033474001 20397633 20400819 GO:0000226 microtubule cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. IEA GO:0000922 spindle pole Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules. IEA GSVIVG01033474001 20397633 20400819 GO:0000226 microtubule cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. IEA GO:0005815 microtubule organizing center A cytoplasmic structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides. IEA GSVIVG01026717001 5382046 5385772 GSVIVG01011906001 3100682 3101924 GSVIVG01032868001 108177 112240 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032059001 23126009 23128455 GSVIVG01013924001 6870574 6871530 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01013924001 6870574 6871530 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01020552001 4452878 4454372 GSVIVG01010083001 15015186 15030833 GSVIVG01026538001 22115188 22125583 GO:0006221 pyrimidine nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-glutamate = ADP + L-glutamate 5-phosphate. IEA GO:0004349 glutamate 5-kinase activity GSVIVG01026538001 22115188 22125583 GO:0006561 proline biosynthetic process The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-glutamate = ADP + L-glutamate 5-phosphate. IEA GO:0004349 glutamate 5-kinase activity GSVIVG01026538001 22115188 22125583 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-glutamate = ADP + L-glutamate 5-phosphate. IEA GO:0004349 glutamate 5-kinase activity GSVIVG01026538001 22115188 22125583 GO:0006221 pyrimidine nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + (d)UMP = ADP + (d)UDP. IEA GO:0009041 uridylate kinase activity GSVIVG01026538001 22115188 22125583 GO:0006561 proline biosynthetic process The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + (d)UMP = ADP + (d)UDP. IEA GO:0009041 uridylate kinase activity GSVIVG01026538001 22115188 22125583 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + (d)UMP = ADP + (d)UDP. IEA GO:0009041 uridylate kinase activity GSVIVG01026538001 22115188 22125583 GO:0006221 pyrimidine nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + UMP = ADP + UDP. IEA GO:0033862 UMP kinase activity GSVIVG01026538001 22115188 22125583 GO:0006561 proline biosynthetic process The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + UMP = ADP + UDP. IEA GO:0033862 UMP kinase activity GSVIVG01026538001 22115188 22125583 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + UMP = ADP + UDP. IEA GO:0033862 UMP kinase activity GSVIVG01030701001 13887145 13935674 GO:0016485 protein processing Any protein maturation process achieved by the cleavage of peptide bonds. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01021731001 10201432 10201990 GSVIVG01023369001 19221975 19226262 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01023369001 19221975 19226262 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01023369001 19221975 19226262 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01023369001 19221975 19226262 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023369001 19221975 19226262 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028015001 3205286 3209147 GSVIVG01009545001 9246451 9251294 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA GSVIVG01009545001 9246451 9251294 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GSVIVG01026549001 21957771 21968697 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01026549001 21957771 21968697 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01026549001 21957771 21968697 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01026549001 21957771 21968697 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01026549001 21957771 21968697 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01026549001 21957771 21968697 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01026549001 21957771 21968697 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026549001 21957771 21968697 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026549001 21957771 21968697 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01026549001 21957771 21968697 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01003327001 9086742 9087102 GO:0009767 photosynthetic electron transport chain A process, occurring as part of photosynthesis, whereby light provides the energy for a series of electron carriers to operate together to transfer electrons and generate a transmembrane electrochemical gradient. IEA GO:0009521 photosystem A complex located in a photosynthetic membrane that consists of a photoreaction center associated with accessory pigments and electron carriers. Examples of this component are found in Arabidopsis thaliana and in photosynthetic bacterial and archaeal species. IEA Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. IEA GO:0016168 chlorophyll binding GSVIVG01003327001 9086742 9087102 GO:0009767 photosynthetic electron transport chain A process, occurring as part of photosynthesis, whereby light provides the energy for a series of electron carriers to operate together to transfer electrons and generate a transmembrane electrochemical gradient. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. IEA GO:0016168 chlorophyll binding GSVIVG01003327001 9086742 9087102 GO:0019684 photosynthesis, light reaction The light reactions of photosynthesis, which take place in photosystems II and I. Light energy is harvested and used to power the transfer of electrons among a series of electron donors and acceptors. The final electron acceptor is NADP+, which is reduced to NADPH. NADPH generated from light reactions is used in sugar synthesis in dark reactions. Light reactions also generate a proton motive force across the thylakoid membrane, and the proton gradient is used to synthesize ATP. There are two chemical reactions involved in the light reactions: water oxidation in photosystem II, and NADP reduction in photosystem I. IEA GO:0009521 photosystem A complex located in a photosynthetic membrane that consists of a photoreaction center associated with accessory pigments and electron carriers. Examples of this component are found in Arabidopsis thaliana and in photosynthetic bacterial and archaeal species. IEA Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. IEA GO:0016168 chlorophyll binding GSVIVG01003327001 9086742 9087102 GO:0019684 photosynthesis, light reaction The light reactions of photosynthesis, which take place in photosystems II and I. Light energy is harvested and used to power the transfer of electrons among a series of electron donors and acceptors. The final electron acceptor is NADP+, which is reduced to NADPH. NADPH generated from light reactions is used in sugar synthesis in dark reactions. Light reactions also generate a proton motive force across the thylakoid membrane, and the proton gradient is used to synthesize ATP. There are two chemical reactions involved in the light reactions: water oxidation in photosystem II, and NADP reduction in photosystem I. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. IEA GO:0016168 chlorophyll binding GSVIVG01030786001 16116638 16120996 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion. IEA GO:0004091 carboxylesterase activity GSVIVG01030786001 16116638 16120996 GO:0016042 lipid catabolic process The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion. IEA GO:0004091 carboxylesterase activity GSVIVG01030786001 16116638 16120996 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion. IEA GO:0004806 triglyceride lipase activity GSVIVG01030786001 16116638 16120996 GO:0016042 lipid catabolic process The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion. IEA GO:0004806 triglyceride lipase activity GSVIVG01026184001 13534094 13544059 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01026184001 13534094 13544059 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01025800001 11733414 11737670 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01025800001 11733414 11737670 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01025800001 11733414 11737670 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01025800001 11733414 11737670 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01023979001 1949695 1949805 GSVIVG01035131001 1707276 1708873 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033212001 9819406 9820188 GSVIVG01018851001 19254180 19256752 GSVIVG01010141001 16211717 16268751 GO:0009234 menaquinone biosynthetic process The chemical reactions and pathways resulting in the formation of any of the menaquinones, any of the quinone-derived compounds synthesized by intestinal bacteria. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones have vitamin K activity and are known as vitamin K2. IEA Interacting selectively and non-covalently with thiamin pyrophosphate, the diphosphoric ester of thiamin. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases. IEA GO:0030976 thiamin pyrophosphate binding GSVIVG01010141001 16211717 16268751 GO:0009234 menaquinone biosynthetic process The chemical reactions and pathways resulting in the formation of any of the menaquinones, any of the quinone-derived compounds synthesized by intestinal bacteria. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones have vitamin K activity and are known as vitamin K2. IEA Catalysis of the reaction: isochorismate + 2-oxoglutarate = 5-enolpyruvoyl-6-hydroxy-2-succinylcyclohex-3-ene-1-carboxylate + CO2. IEA GO:0070204 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity GSVIVG01034116001 15057136 15059221 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01034116001 15057136 15059221 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01034116001 15057136 15059221 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01034116001 15057136 15059221 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01034116001 15057136 15059221 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01034116001 15057136 15059221 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01034116001 15057136 15059221 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01034116001 15057136 15059221 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01034116001 15057136 15059221 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01034116001 15057136 15059221 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01034116001 15057136 15059221 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01034116001 15057136 15059221 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01034116001 15057136 15059221 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01034116001 15057136 15059221 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01034116001 15057136 15059221 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01032575001 28492642 28495551 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032575001 28492642 28495551 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032575001 28492642 28495551 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01032575001 28492642 28495551 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01032575001 28492642 28495551 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01032575001 28492642 28495551 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01035260001 11555483 11560214 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01035260001 11555483 11560214 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01035260001 11555483 11560214 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01035260001 11555483 11560214 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006940001 29148702 29182488 GSVIVG01037207001 27975112 27979339 GSVIVG01035307001 241463 245778 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o) All non-F1 subunits of a hydrogen-transporting ATP synthase, including integral and peripheral membrane proteins. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01035307001 241463 245778 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o) All non-F1 subunits of a hydrogen-transporting ATP synthase, including integral and peripheral membrane proteins. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01035307001 241463 245778 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o) All non-F1 subunits of a hydrogen-transporting ATP synthase, including integral and peripheral membrane proteins. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01035307001 241463 245778 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o) All non-F1 subunits of a hydrogen-transporting ATP synthase, including integral and peripheral membrane proteins. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01035307001 241463 245778 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o) All non-F1 subunits of a hydrogen-transporting ATP synthase, including integral and peripheral membrane proteins. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01035307001 241463 245778 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o) All non-F1 subunits of a hydrogen-transporting ATP synthase, including integral and peripheral membrane proteins. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01035307001 241463 245778 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o) All non-F1 subunits of a hydrogen-transporting ATP synthase, including integral and peripheral membrane proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035307001 241463 245778 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o) All non-F1 subunits of a hydrogen-transporting ATP synthase, including integral and peripheral membrane proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035307001 241463 245778 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o) All non-F1 subunits of a hydrogen-transporting ATP synthase, including integral and peripheral membrane proteins. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01035307001 241463 245778 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o) All non-F1 subunits of a hydrogen-transporting ATP synthase, including integral and peripheral membrane proteins. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01028452001 7797511 7804399 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028452001 7797511 7804399 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028452001 7797511 7804399 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028452001 7797511 7804399 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028452001 7797511 7804399 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028452001 7797511 7804399 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028452001 7797511 7804399 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028452001 7797511 7804399 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028452001 7797511 7804399 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01028452001 7797511 7804399 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01028452001 7797511 7804399 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01028452001 7797511 7804399 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01028452001 7797511 7804399 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01028452001 7797511 7804399 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01028452001 7797511 7804399 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01028452001 7797511 7804399 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01028452001 7797511 7804399 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01028452001 7797511 7804399 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01028452001 7797511 7804399 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01028452001 7797511 7804399 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01013153001 7493344 7494941 GO:0051260 protein homooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01020074001 10704909 10741870 GSVIVG01004909001 4737981 4745369 GO:0006415 translational termination The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code). IEA Involved in catalyzing the release of a nascent polypeptide chain from a ribosome. IEA GO:0003747 translation release factor activity GSVIVG01023423001 12266259 12266534 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01023423001 12266259 12266534 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01023423001 12266259 12266534 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o) All non-F1 subunits of a hydrogen-transporting ATP synthase, including integral and peripheral membrane proteins. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01019606001 1895467 1900156 GSVIVG01013319001 11878739 11880214 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01013319001 11878739 11880214 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01013319001 11878739 11880214 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01028919001 17546563 17566153 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01010906001 15909151 15915765 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01035311001 314872 324465 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01035311001 314872 324465 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01035311001 314872 324465 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01035311001 314872 324465 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035311001 314872 324465 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006256001 24125920 24127059 GSVIVG01004812001 111796 117184 GSVIVG01024125001 905892 909162 GSVIVG01026837001 20084228 20093332 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026837001 20084228 20093332 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026837001 20084228 20093332 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026837001 20084228 20093332 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026837001 20084228 20093332 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01026837001 20084228 20093332 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01010625001 15894465 15895136 GSVIVG01030095001 9776927 9782854 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01009548001 9273802 9288920 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA GSVIVG01009548001 9273802 9288920 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GSVIVG01021106001 1483255 1486078 GSVIVG01037987001 12078488 12079924 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01037987001 12078488 12079924 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01037987001 12078488 12079924 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01037987001 12078488 12079924 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01015441001 3708309 3717812 GSVIVG01022175001 17216508 17219062 GSVIVG01020946001 16668019 16668474 GSVIVG01023116001 22397723 22403254 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01023116001 22397723 22403254 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01023116001 22397723 22403254 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01023116001 22397723 22403254 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01023116001 22397723 22403254 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01023116001 22397723 22403254 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01023116001 22397723 22403254 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01023116001 22397723 22403254 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01008851001 2813081 2821818 GO:0006779 porphyrin biosynthetic process The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group. IEA Catalysis of the reaction: 2 H2O2 = O2 + 2 H2O. IEA GO:0004096 catalase activity GSVIVG01008851001 2813081 2821818 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: 2 H2O2 = O2 + 2 H2O. IEA GO:0004096 catalase activity GSVIVG01008851001 2813081 2821818 GO:0033014 tetrapyrrole biosynthetic process The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. IEA Catalysis of the reaction: 2 H2O2 = O2 + 2 H2O. IEA GO:0004096 catalase activity GSVIVG01008851001 2813081 2821818 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2 H2O2 = O2 + 2 H2O. IEA GO:0004096 catalase activity GSVIVG01008851001 2813081 2821818 GO:0006779 porphyrin biosynthetic process The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01008851001 2813081 2821818 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01008851001 2813081 2821818 GO:0033014 tetrapyrrole biosynthetic process The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01008851001 2813081 2821818 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01008851001 2813081 2821818 GO:0006779 porphyrin biosynthetic process The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group. IEA Catalysis of the reaction: 2 5-aminolevulinate = porphobilinogen + 2 H2O. IEA GO:0004655 porphobilinogen synthase activity GSVIVG01008851001 2813081 2821818 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: 2 5-aminolevulinate = porphobilinogen + 2 H2O. IEA GO:0004655 porphobilinogen synthase activity GSVIVG01008851001 2813081 2821818 GO:0033014 tetrapyrrole biosynthetic process The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. IEA Catalysis of the reaction: 2 5-aminolevulinate = porphobilinogen + 2 H2O. IEA GO:0004655 porphobilinogen synthase activity GSVIVG01008851001 2813081 2821818 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2 5-aminolevulinate = porphobilinogen + 2 H2O. IEA GO:0004655 porphobilinogen synthase activity GSVIVG01008851001 2813081 2821818 GO:0006779 porphyrin biosynthetic process The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01008851001 2813081 2821818 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01008851001 2813081 2821818 GO:0033014 tetrapyrrole biosynthetic process The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01008851001 2813081 2821818 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01008851001 2813081 2821818 GO:0006779 porphyrin biosynthetic process The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01008851001 2813081 2821818 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01008851001 2813081 2821818 GO:0033014 tetrapyrrole biosynthetic process The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01008851001 2813081 2821818 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01008851001 2813081 2821818 GO:0006779 porphyrin biosynthetic process The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01008851001 2813081 2821818 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01008851001 2813081 2821818 GO:0033014 tetrapyrrole biosynthetic process The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01008851001 2813081 2821818 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01023893001 2620300 2622993 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01023893001 2620300 2622993 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035317001 408260 409072 GSVIVG01012373001 222967 229089 GSVIVG01032898001 23920911 23938859 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01032898001 23920911 23938859 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01032898001 23920911 23938859 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01032898001 23920911 23938859 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01032898001 23920911 23938859 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01032898001 23920911 23938859 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01032898001 23920911 23938859 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01032898001 23920911 23938859 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01032898001 23920911 23938859 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01032898001 23920911 23938859 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032898001 23920911 23938859 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032898001 23920911 23938859 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032898001 23920911 23938859 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01032898001 23920911 23938859 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01032898001 23920911 23938859 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01032898001 23920911 23938859 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01032898001 23920911 23938859 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01032898001 23920911 23938859 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01032898001 23920911 23938859 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01032898001 23920911 23938859 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01032898001 23920911 23938859 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01007544001 12379862 12388649 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007544001 12379862 12388649 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. IEA GO:0008080 N-acetyltransferase activity GSVIVG01007544001 12379862 12388649 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01020059001 10983756 10987218 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01020059001 10983756 10987218 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01009077001 4745557 4752639 GSVIVG01012929001 13695714 13701570 GSVIVG01013027001 9983202 9995416 GSVIVG01031407001 19004664 19013824 GSVIVG01019896001 4323523 4327771 GSVIVG01028220001 4729295 4730035 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with manganese (Mn) ions. IEA GO:0030145 manganese ion binding GSVIVG01028220001 4729295 4730035 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Functions in the storage of nutritious substrates. IEA GO:0045735 nutrient reservoir activity GSVIVG01025588001 13840866 13841066 GSVIVG01034493001 20434241 20441673 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01034493001 20434241 20441673 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01034493001 20434241 20441673 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01034493001 20434241 20441673 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01034493001 20434241 20441673 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034838001 22472566 22473188 GSVIVG01038333001 13124003 13125777 GSVIVG01021009001 15363272 15434023 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01011193001 9273600 9281271 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01011193001 9273600 9281271 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01011193001 9273600 9281271 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011193001 9273600 9281271 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003174001 5981436 5989264 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01003174001 5981436 5989264 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01003174001 5981436 5989264 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01009707001 10658105 10663144 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009707001 10658105 10663144 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01009707001 10658105 10663144 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0010181 FMN binding GSVIVG01009707001 10658105 10663144 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01009707001 10658105 10663144 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01025840001 11323614 11328620 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01007785001 9032365 9039270 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01007785001 9032365 9039270 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01007785001 9032365 9039270 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01007785001 9032365 9039270 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01007785001 9032365 9039270 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01007785001 9032365 9039270 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01007785001 9032365 9039270 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01007785001 9032365 9039270 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01007785001 9032365 9039270 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01007785001 9032365 9039270 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01007785001 9032365 9039270 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01007785001 9032365 9039270 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01007785001 9032365 9039270 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01007785001 9032365 9039270 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01007785001 9032365 9039270 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01007785001 9032365 9039270 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01001549001 1435835 1436227 GSVIVG01002955001 37344947 37345587 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019415001 479436 487361 GO:0016114 terpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure. IEA Catalysis of the reaction: 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + CMP. IEA GO:0008685 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity GSVIVG01024755001 7194372 7194413 GSVIVG01019324001 1106470 1112644 GSVIVG01033372001 21129154 21136566 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01009236001 6511946 6512743 GSVIVG01028496001 8455346 8455738 GSVIVG01035176001 12835858 12838811 GSVIVG01028732001 19309225 19310778 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GSVIVG01014375001 3167258 3183140 GSVIVG01008573001 784245 786076 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. IEA GO:0005179 hormone activity GSVIVG01008573001 784245 786076 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01027878001 8930079 8934179 GSVIVG01013450001 381745 387296 GO:0009765 photosynthesis, light harvesting Absorption and transfer of the energy absorbed from light photons between photosystem reaction centers. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01031283001 619000 623495 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005801 cis-Golgi network The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum. IEA GSVIVG01031283001 619000 623495 GO:0006888 ER to Golgi vesicle-mediated transport The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi. IEA GO:0005801 cis-Golgi network The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum. IEA GSVIVG01017539001 10185950 10186801 GSVIVG01007883001 7961696 7972366 GSVIVG01037168001 28357802 28360311 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01037168001 28357802 28360311 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01008076001 6022005 6029128 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01008076001 6022005 6029128 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01026353001 14706473 14710080 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01014581001 5361074 5369818 GO:0016043 cellular component organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cellular component. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01014581001 5361074 5369818 GO:0030036 actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01007215001 30918200 30924232 GSVIVG01020909001 17396353 17430590 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01027973001 2917267 2918890 GSVIVG01025763001 12137553 12140310 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004185 serine-type carboxypeptidase activity GSVIVG01000115001 15373191 15378107 GO:0006820 anion transport The directed movement of anions, atoms or small molecules with a net negative charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005741 mitochondrial outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope. IEA Catalysis of the transmembrane transfer of an anion by a voltage-gated channel. An anion is a negatively charged ion. IEA GO:0008308 voltage-gated anion channel activity GSVIVG01000115001 15373191 15378107 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005741 mitochondrial outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope. IEA Catalysis of the transmembrane transfer of an anion by a voltage-gated channel. An anion is a negatively charged ion. IEA GO:0008308 voltage-gated anion channel activity GSVIVG01037411001 14213338 14226707 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01036869001 18431308 18435037 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01036869001 18431308 18435037 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036869001 18431308 18435037 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01036869001 18431308 18435037 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01009369001 7839602 7843143 Interacting selectively and non-covalently with acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group. IEA GO:0000062 acyl-CoA binding GSVIVG01009369001 7839602 7843143 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01000580001 6877619 6883938 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01000580001 6877619 6883938 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01000580001 6877619 6883938 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000580001 6877619 6883938 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000580001 6877619 6883938 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01000580001 6877619 6883938 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01000580001 6877619 6883938 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01000580001 6877619 6883938 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01000580001 6877619 6883938 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01000580001 6877619 6883938 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01030310001 9110039 9117001 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01030310001 9110039 9117001 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01030310001 9110039 9117001 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01030310001 9110039 9117001 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01030310001 9110039 9117001 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026518001 22313152 22315063 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the reaction: pectin + n H2O = n methanol + pectate. IEA GO:0030599 pectinesterase activity GSVIVG01026518001 22313152 22315063 GO:0043087 regulation of GTPase activity Any process that modulates the rate of GTP hydrolysis by a GTPase. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the reaction: pectin + n H2O = n methanol + pectate. IEA GO:0030599 pectinesterase activity GSVIVG01026031001 25544863 25545437 GSVIVG01011035001 2077504 2079231 GSVIVG01026052001 25258427 25272284 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01010940001 2812413 2813812 GSVIVG01034108001 15111231 15113604 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01034108001 15111231 15113604 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01034108001 15111231 15113604 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01034108001 15111231 15113604 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01034108001 15111231 15113604 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028236001 4846491 4849285 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01028236001 4846491 4849285 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01028236001 4846491 4849285 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01028236001 4846491 4849285 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01028236001 4846491 4849285 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01028236001 4846491 4849285 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01031430001 18665350 18674795 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01026501001 22531684 22533280 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026501001 22531684 22533280 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01029547001 21757868 21760527 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01012762001 23682046 23690594 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01012762001 23682046 23690594 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01012762001 23682046 23690594 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01012762001 23682046 23690594 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01012762001 23682046 23690594 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01012762001 23682046 23690594 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01012762001 23682046 23690594 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01012762001 23682046 23690594 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01012762001 23682046 23690594 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012762001 23682046 23690594 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012762001 23682046 23690594 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012762001 23682046 23690594 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012762001 23682046 23690594 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012762001 23682046 23690594 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012762001 23682046 23690594 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012762001 23682046 23690594 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012762001 23682046 23690594 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01012762001 23682046 23690594 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01012762001 23682046 23690594 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01012762001 23682046 23690594 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01016280001 5579851 5581098 GSVIVG01028005001 3130298 3135995 GSVIVG01033204001 9681073 9687040 GSVIVG01014866001 10840648 10841808 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01012714001 915919 919949 Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal. IEA GO:0004462 lactoylglutathione lyase activity GSVIVG01012714001 915919 919949 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01030849001 17566976 17567280 GSVIVG01018423001 9187167 9206998 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01018423001 9187167 9206998 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01018423001 9187167 9206998 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01018423001 9187167 9206998 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021956001 5092337 5094411 GSVIVG01016122001 19476909 19482693 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016122001 19476909 19482693 GO:0006564 L-serine biosynthetic process The chemical reactions and pathways resulting in the formation of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016122001 19476909 19482693 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016122001 19476909 19482693 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016122001 19476909 19482693 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016122001 19476909 19482693 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+. IEA GO:0004617 phosphoglycerate dehydrogenase activity GSVIVG01016122001 19476909 19482693 GO:0006564 L-serine biosynthetic process The chemical reactions and pathways resulting in the formation of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. IEA Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+. IEA GO:0004617 phosphoglycerate dehydrogenase activity GSVIVG01016122001 19476909 19482693 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+. IEA GO:0004617 phosphoglycerate dehydrogenase activity GSVIVG01016122001 19476909 19482693 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+. IEA GO:0004617 phosphoglycerate dehydrogenase activity GSVIVG01016122001 19476909 19482693 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+. IEA GO:0004617 phosphoglycerate dehydrogenase activity GSVIVG01016122001 19476909 19482693 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016122001 19476909 19482693 GO:0006564 L-serine biosynthetic process The chemical reactions and pathways resulting in the formation of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016122001 19476909 19482693 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016122001 19476909 19482693 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016122001 19476909 19482693 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016122001 19476909 19482693 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01016122001 19476909 19482693 GO:0006564 L-serine biosynthetic process The chemical reactions and pathways resulting in the formation of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01016122001 19476909 19482693 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01016122001 19476909 19482693 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01016122001 19476909 19482693 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01016122001 19476909 19482693 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016122001 19476909 19482693 GO:0006564 L-serine biosynthetic process The chemical reactions and pathways resulting in the formation of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016122001 19476909 19482693 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016122001 19476909 19482693 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016122001 19476909 19482693 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016122001 19476909 19482693 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. IEA GO:0016597 amino acid binding GSVIVG01016122001 19476909 19482693 GO:0006564 L-serine biosynthetic process The chemical reactions and pathways resulting in the formation of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. IEA Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. IEA GO:0016597 amino acid binding GSVIVG01016122001 19476909 19482693 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. IEA GO:0016597 amino acid binding GSVIVG01016122001 19476909 19482693 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. IEA GO:0016597 amino acid binding GSVIVG01016122001 19476909 19482693 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. IEA GO:0016597 amino acid binding GSVIVG01016122001 19476909 19482693 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01016122001 19476909 19482693 GO:0006564 L-serine biosynthetic process The chemical reactions and pathways resulting in the formation of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01016122001 19476909 19482693 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01016122001 19476909 19482693 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01016122001 19476909 19482693 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01016122001 19476909 19482693 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. IEA GO:0048037 cofactor binding GSVIVG01016122001 19476909 19482693 GO:0006564 L-serine biosynthetic process The chemical reactions and pathways resulting in the formation of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. IEA Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. IEA GO:0048037 cofactor binding GSVIVG01016122001 19476909 19482693 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. IEA GO:0048037 cofactor binding GSVIVG01016122001 19476909 19482693 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. IEA GO:0048037 cofactor binding GSVIVG01016122001 19476909 19482693 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. IEA GO:0048037 cofactor binding GSVIVG01016122001 19476909 19482693 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01016122001 19476909 19482693 GO:0006564 L-serine biosynthetic process The chemical reactions and pathways resulting in the formation of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01016122001 19476909 19482693 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01016122001 19476909 19482693 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01016122001 19476909 19482693 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01004975001 17198038 17198876 GO:0006461 protein complex assembly The aggregation, arrangement and bonding together of a set of components to form a protein complex. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells. IEA GO:0015232 heme transporter activity GSVIVG01004975001 17198038 17198876 GO:0008535 respiratory chain complex IV assembly The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase), the terminal member of the respiratory chain of the mitochondrion and some aerobic bacteria. Cytochrome c oxidases are multi-subunit enzymes containing from 13 subunits in the mammalian mitochondrial form to 3-4 subunits in the bacterial forms. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells. IEA GO:0015232 heme transporter activity GSVIVG01004975001 17198038 17198876 GO:0015886 heme transport The directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells. IEA GO:0015232 heme transporter activity GSVIVG01004975001 17198038 17198876 GO:0017004 cytochrome complex assembly The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells. IEA GO:0015232 heme transporter activity GSVIVG01022491001 3793012 3795556 GSVIVG01033343001 21345708 21348717 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01033343001 21345708 21348717 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01033343001 21345708 21348717 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01033343001 21345708 21348717 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033343001 21345708 21348717 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026981001 18842560 18865523 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01026981001 18842560 18865523 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01015647001 14838441 14853111 GSVIVG01029544001 21788416 21789428 GSVIVG01032450001 27512590 27524855 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01032450001 27512590 27524855 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA Catalysis of the reaction: formyl-L-methionyl peptide + H2O = formate + methionyl peptide. IEA GO:0042586 peptide deformylase activity GSVIVG01032566001 28408224 28415858 GSVIVG01008322001 3261766 3265505 GSVIVG01018171001 13639604 13645418 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01018171001 13639604 13645418 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01037596001 10206608 10206904 GSVIVG01016774001 1229946 1233532 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016774001 1229946 1233532 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01013404001 673421 679783 GO:0007021 tubulin complex assembly The aggregation and bonding together of alpha- and beta-tubulin to form a tubulin heterodimer. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01024205001 291232 302906 GSVIVG01025749001 12250072 12253534 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01037065001 8229084 8232564 GSVIVG01017180001 5054690 5067884 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01017613001 2014665 2033653 GSVIVG01004287001 37980380 37981191 GSVIVG01008642001 184743 190323 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008642001 184743 190323 GO:0006013 mannose metabolic process The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008642001 184743 190323 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01008642001 184743 190323 GO:0006013 mannose metabolic process The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01008642001 184743 190323 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. IEA GO:0004559 alpha-mannosidase activity GSVIVG01008642001 184743 190323 GO:0006013 mannose metabolic process The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins. IEA Catalysis of the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. IEA GO:0004559 alpha-mannosidase activity GSVIVG01008642001 184743 190323 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008642001 184743 190323 GO:0006013 mannose metabolic process The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008642001 184743 190323 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of mannosyl compounds, substances containing a group derived from a cyclic form of mannose or a mannose derivative. IEA GO:0015923 mannosidase activity GSVIVG01008642001 184743 190323 GO:0006013 mannose metabolic process The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins. IEA Catalysis of the hydrolysis of mannosyl compounds, substances containing a group derived from a cyclic form of mannose or a mannose derivative. IEA GO:0015923 mannosidase activity GSVIVG01008642001 184743 190323 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01008642001 184743 190323 GO:0006013 mannose metabolic process The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins. IEA Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01038180001 24119279 24122796 GSVIVG01031401001 19063713 19075630 GSVIVG01001186001 1020349 1025793 Functions in the storage of nutritious substrates. IEA GO:0045735 nutrient reservoir activity GSVIVG01022162001 17141405 17147441 GSVIVG01010717001 12440458 12440586 GSVIVG01023432001 12105751 12118137 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023432001 12105751 12118137 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023432001 12105751 12118137 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023432001 12105751 12118137 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023432001 12105751 12118137 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023432001 12105751 12118137 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023432001 12105751 12118137 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01023432001 12105751 12118137 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01037714001 7199188 7201533 GSVIVG01027794001 7811925 7812966 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01027794001 7811925 7812966 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01022244001 17787117 17793139 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01022244001 17787117 17793139 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01022244001 17787117 17793139 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01022244001 17787117 17793139 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01022244001 17787117 17793139 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01022244001 17787117 17793139 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01037700001 7070075 7070686 GSVIVG01027980001 2940296 2941537 GSVIVG01027797001 7852288 7853290 GSVIVG01026993001 18731174 18734997 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01026993001 18731174 18734997 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01026993001 18731174 18734997 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01026993001 18731174 18734997 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01006506001 42514674 42515259 GSVIVG01023890001 2643176 2645835 GSVIVG01018248001 12553413 12565571 GO:0030833 regulation of actin filament polymerization Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament. IEA GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA GSVIVG01012346001 789119 793684 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01012346001 789119 793684 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01012346001 789119 793684 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01012346001 789119 793684 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01012346001 789119 793684 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01012346001 789119 793684 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025198001 3442998 3447976 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025198001 3442998 3447976 GO:0009725 response to hormone stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025198001 3442998 3447976 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025198001 3442998 3447976 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01025198001 3442998 3447976 GO:0009725 response to hormone stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01025198001 3442998 3447976 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01025078001 4742457 4743482 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025078001 4742457 4743482 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025078001 4742457 4743482 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01025078001 4742457 4743482 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01025078001 4742457 4743482 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01025078001 4742457 4743482 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01025078001 4742457 4743482 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01025078001 4742457 4743482 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01003136001 7548022 7550522 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals. IEA GO:0008519 ammonium transmembrane transporter activity GSVIVG01003136001 7548022 7550522 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals. IEA GO:0008519 ammonium transmembrane transporter activity GSVIVG01015163001 1477730 1479021 GSVIVG01036066001 21139821 21143646 GSVIVG01020702001 2997160 3002040 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01020702001 2997160 3002040 GO:0009231 riboflavin biosynthetic process The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01020702001 2997160 3002040 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: ATP + riboflavin = ADP + FMN. IEA GO:0008531 riboflavin kinase activity GSVIVG01020702001 2997160 3002040 GO:0009231 riboflavin biosynthetic process The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). IEA Catalysis of the reaction: ATP + riboflavin = ADP + FMN. IEA GO:0008531 riboflavin kinase activity GSVIVG01020702001 2997160 3002040 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2-phosphoglycolate + H2O = glycolate + phosphate. IEA GO:0008967 phosphoglycolate phosphatase activity GSVIVG01020702001 2997160 3002040 GO:0009231 riboflavin biosynthetic process The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). IEA Catalysis of the reaction: 2-phosphoglycolate + H2O = glycolate + phosphate. IEA GO:0008967 phosphoglycolate phosphatase activity GSVIVG01020702001 2997160 3002040 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01020702001 2997160 3002040 GO:0009231 riboflavin biosynthetic process The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01037362001 15015952 15020966 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025331001 1964099 1964524 GSVIVG01027940001 9780151 9799953 GSVIVG01014510001 4663025 4665761 GSVIVG01004854001 71693 93286 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009231001 6473658 6486710 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01009231001 6473658 6486710 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01009231001 6473658 6486710 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01037182001 28260003 28262148 GSVIVG01005974001 23065893 23068693 GSVIVG01014135001 690589 692477 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012904001 13182223 13232151 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01012904001 13182223 13232151 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01012904001 13182223 13232151 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate. IEA GO:0019001 guanyl nucleotide binding GSVIVG01012904001 13182223 13232151 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate. IEA GO:0019001 guanyl nucleotide binding GSVIVG01017682001 2606493 2622986 GSVIVG01013413001 620592 623967 GSVIVG01022004001 4396193 4396833 GSVIVG01035211001 10548708 10552163 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01035211001 10548708 10552163 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01035211001 10548708 10552163 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01035211001 10548708 10552163 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035211001 10548708 10552163 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022313001 18412742 18415988 GO:0042256 mature ribosome assembly The aggregation, arrangement and bonding together of the large and small ribosomal subunits into a functional ribosome. IEA Interacting selectively and non-covalently with any part of a ribosome. IEA GO:0043022 ribosome binding GSVIVG01029095001 12427632 12428669 GSVIVG01013470001 170187 176322 GSVIVG01024505001 3450206 3451075 GSVIVG01009185001 5872897 5891275 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01009185001 5872897 5891275 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0010181 FMN binding GSVIVG01009185001 5872897 5891275 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01028131001 4056114 4057820 GSVIVG01017445001 8610434 8616666 GO:0006571 tyrosine biosynthetic process The chemical reactions and pathways resulting in the formation of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01017445001 8610434 8616666 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01017445001 8610434 8616666 GO:0006571 tyrosine biosynthetic process The chemical reactions and pathways resulting in the formation of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid. IEA Catalysis of the reaction: prephenate + NADP+ = 4-hydroxyphenylpyruvate + CO2 + NADPH + H+. IEA GO:0004665 prephenate dehydrogenase (NADP+) activity GSVIVG01017445001 8610434 8616666 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: prephenate + NADP+ = 4-hydroxyphenylpyruvate + CO2 + NADPH + H+. IEA GO:0004665 prephenate dehydrogenase (NADP+) activity GSVIVG01017445001 8610434 8616666 GO:0006571 tyrosine biosynthetic process The chemical reactions and pathways resulting in the formation of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017445001 8610434 8616666 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026866001 19786199 19802410 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01026866001 19786199 19802410 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01026866001 19786199 19802410 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01026866001 19786199 19802410 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026866001 19786199 19802410 Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01026866001 19786199 19802410 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01012733001 1089301 1090111 GSVIVG01024665001 7953392 7955473 GSVIVG01008209001 4650027 4650725 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01008209001 4650027 4650725 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01008209001 4650027 4650725 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01008209001 4650027 4650725 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023389001 12924819 12926029 GSVIVG01017693001 2694321 2697616 GO:0001522 pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01017693001 2694321 2697616 GO:0009451 RNA modification The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01017693001 2694321 2697616 GO:0001522 pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs. IEA Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. IEA GO:0009982 pseudouridine synthase activity GSVIVG01017693001 2694321 2697616 GO:0009451 RNA modification The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. IEA Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. IEA GO:0009982 pseudouridine synthase activity GSVIVG01018030001 5689057 5690169 GSVIVG01016955001 2946717 2952100 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016955001 2946717 2952100 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01016955001 2946717 2952100 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01016955001 2946717 2952100 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01020540001 4671236 4676148 GSVIVG01027585001 15309083 15326318 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01027585001 15309083 15326318 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01027585001 15309083 15326318 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01027585001 15309083 15326318 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01009342001 7559617 7566206 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01009342001 7559617 7566206 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01022254001 17871459 17884417 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01022254001 17871459 17884417 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01022254001 17871459 17884417 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01022254001 17871459 17884417 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01012811001 5621351 5622710 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016845001 1886686 1891994 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01016845001 1886686 1891994 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01016845001 1886686 1891994 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01016845001 1886686 1891994 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01022844001 18833679 18834953 GSVIVG01016172001 7065253 7070896 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016172001 7065253 7070896 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016172001 7065253 7070896 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016172001 7065253 7070896 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016172001 7065253 7070896 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016172001 7065253 7070896 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016172001 7065253 7070896 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016172001 7065253 7070896 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016172001 7065253 7070896 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016172001 7065253 7070896 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016172001 7065253 7070896 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016172001 7065253 7070896 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016172001 7065253 7070896 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. IEA GO:0016615 malate dehydrogenase activity GSVIVG01016172001 7065253 7070896 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. IEA GO:0016615 malate dehydrogenase activity GSVIVG01016172001 7065253 7070896 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. IEA GO:0016615 malate dehydrogenase activity GSVIVG01016172001 7065253 7070896 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. IEA GO:0016615 malate dehydrogenase activity GSVIVG01016172001 7065253 7070896 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: (S)-malate + NADP+ = oxaloacetate + NADPH + H+. IEA GO:0046554 malate dehydrogenase (NADP+) activity GSVIVG01016172001 7065253 7070896 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Catalysis of the reaction: (S)-malate + NADP+ = oxaloacetate + NADPH + H+. IEA GO:0046554 malate dehydrogenase (NADP+) activity GSVIVG01016172001 7065253 7070896 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: (S)-malate + NADP+ = oxaloacetate + NADPH + H+. IEA GO:0046554 malate dehydrogenase (NADP+) activity GSVIVG01016172001 7065253 7070896 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: (S)-malate + NADP+ = oxaloacetate + NADPH + H+. IEA GO:0046554 malate dehydrogenase (NADP+) activity GSVIVG01026885001 19649533 19650099 GSVIVG01032127001 22417390 22418610 GSVIVG01028788001 18812895 18822232 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01001068001 7244942 7246174 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001068001 7244942 7246174 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001068001 7244942 7246174 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01001068001 7244942 7246174 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01001068001 7244942 7246174 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01001068001 7244942 7246174 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01001068001 7244942 7246174 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01001068001 7244942 7246174 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01030628001 7291808 7293953 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01028309001 5978292 5980037 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024220001 120122 125179 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01024220001 120122 125179 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01024220001 120122 125179 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01013995001 8661140 8663788 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013995001 8661140 8663788 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013995001 8661140 8663788 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013995001 8661140 8663788 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01013995001 8661140 8663788 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01013995001 8661140 8663788 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01009965001 12887374 12890186 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01009965001 12887374 12890186 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01001493001 5144778 5147841 GSVIVG01021134001 1737636 1739104 Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. IEA GO:0008171 O-methyltransferase activity GSVIVG01021678001 9190809 9191173 GSVIVG01012845001 6038848 6040780 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01029892001 995521 1021768 GSVIVG01003798001 201678 209816 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01003798001 201678 209816 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: linoleate + O2 = (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate. IEA GO:0016165 lipoxygenase activity GSVIVG01003798001 201678 209816 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor. IEA GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen GSVIVG01003798001 201678 209816 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01010859001 16774466 16788785 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01035379001 890766 891570 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01035379001 890766 891570 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01013808001 7385836 7387183 GSVIVG01027535001 15941193 15945239 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with vasopressin to initiate a change in cell activity. IEA GO:0005000 vasopressin receptor activity GSVIVG01028801001 18657281 18659016 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01028801001 18657281 18659016 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01028801001 18657281 18659016 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01005251001 19841409 19842343 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025952001 26756041 26758590 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01025952001 26756041 26758590 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01025952001 26756041 26758590 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01025952001 26756041 26758590 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01025599001 13721351 13721842 GSVIVG01007727001 9879460 9885641 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01007727001 9879460 9885641 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA Catalysis of the hydrolysis of ester linkages within nucleic acids. IEA GO:0004518 nuclease activity GSVIVG01014357001 2974604 2975506 GSVIVG01003806001 311920 313629 GSVIVG01033626001 19138476 19139355 GSVIVG01020061001 10929347 10935415 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01020061001 10929347 10935415 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033689001 18645701 18669017 GO:0046488 phosphatidylinositol metabolic process The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033689001 18645701 18669017 GO:0046488 phosphatidylinositol metabolic process The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. IEA Catalysis of the phosphorylation of phosphatidylinositol phosphate to produce phosphatidylinositol bisphosphate. IEA GO:0016307 phosphatidylinositol phosphate kinase activity GSVIVG01033689001 18645701 18669017 GO:0046488 phosphatidylinositol metabolic process The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. IEA Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate. IEA GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity GSVIVG01035177001 12860386 12861633 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01013285001 5660755 5666970 GSVIVG01014747001 9160945 9162797 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014747001 9160945 9162797 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014747001 9160945 9162797 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01014747001 9160945 9162797 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01023464001 11440462 11454690 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Functions to initiate or regulate RNA polymerase II transcription. IEA GO:0003702 RNA polymerase II transcription factor activity GSVIVG01031331001 321213 327475 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01031331001 321213 327475 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01007579001 11716242 11717170 GSVIVG01013892001 6239590 6245278 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01010134001 16053500 16055307 GSVIVG01014378001 3220030 3220137 GSVIVG01037507001 12555824 12557873 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01011051001 1959405 1962611 GO:0006464 protein modification process The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01011051001 1959405 1962611 GO:0009107 lipoate biosynthetic process The chemical reactions and pathways resulting in the formation of lipoate, 1,2-dithiolane-3-pentanoate, the anion derived from lipoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01011051001 1959405 1962611 GO:0006464 protein modification process The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of an octanoyl (CH3-[CH2]6-CO-) group to an acceptor molecule. IEA GO:0016415 octanoyltransferase activity GSVIVG01011051001 1959405 1962611 GO:0009107 lipoate biosynthetic process The chemical reactions and pathways resulting in the formation of lipoate, 1,2-dithiolane-3-pentanoate, the anion derived from lipoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of an octanoyl (CH3-[CH2]6-CO-) group to an acceptor molecule. IEA GO:0016415 octanoyltransferase activity GSVIVG01016074001 18395010 18410644 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01016074001 18395010 18410644 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01016074001 18395010 18410644 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01016074001 18395010 18410644 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014533001 4899078 4903139 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014533001 4899078 4903139 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014533001 4899078 4903139 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014533001 4899078 4903139 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014533001 4899078 4903139 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014533001 4899078 4903139 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014533001 4899078 4903139 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with the neurotransmitter dopamine to initiate a change in cell activity. IEA GO:0004952 dopamine receptor activity GSVIVG01014533001 4899078 4903139 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with the neurotransmitter dopamine to initiate a change in cell activity. IEA GO:0004952 dopamine receptor activity GSVIVG01014533001 4899078 4903139 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014533001 4899078 4903139 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025561001 14060446 14061173 GO:0032313 regulation of Rab GTPase activity Any process that modulates the activity of a GTPase of the Rab family. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Increases the rate of GTP hydrolysis by a GTPase of the Rab family. IEA GO:0005097 Rab GTPase activator activity GSVIVG01013362001 961811 966293 GSVIVG01033297001 21721904 21731344 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033297001 21721904 21731344 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01033297001 21721904 21731344 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01037957001 11545933 11548757 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01037957001 11545933 11548757 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01036773001 22741010 22745951 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. IEA GO:0004618 phosphoglycerate kinase activity GSVIVG01036773001 22741010 22745951 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01036773001 22741010 22745951 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01013655001 2003756 2020790 GSVIVG01016365001 4447793 4452812 GO:0006465 signal peptide processing The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell. IEA GO:0005787 signal peptidase complex A protein complex that is located in the endoplasmic reticulum membrane and cleaves the signal sequence from precursor proteins following their transport out of the cytoplasmic space. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01016365001 4447793 4452812 GO:0006465 signal peptide processing The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01019006001 17877477 17879808 GSVIVG01034055001 15501886 15503141 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA GSVIVG01034026001 15745032 15751315 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01034026001 15745032 15751315 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01013083001 8573734 8582220 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01029497001 22245054 22245191 GSVIVG01008905001 3298909 3306668 GO:0009252 peptidoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls. IEA GO:0009274 peptidoglycan-based cell wall A protective structure outside the cytoplasmic membrane composed of peptidoglycan (also known as murein), a molecule made up of a glycan (sugar) backbone of repetitively alternating N-acetylglucosamine and N-acetylmuramic acid with short, attached, cross-linked peptide chains containing unusual amino acids. An example of this component is found in Escherichia coli. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012969001 11554981 11575642 GSVIVG01032844001 310143 315069 GSVIVG01000449001 8112958 8114197 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01020128001 10067645 10075460 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01001280001 4951821 4956004 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01001280001 4951821 4956004 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01001280001 4951821 4956004 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01001280001 4951821 4956004 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01001280001 4951821 4956004 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001280001 4951821 4956004 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001280001 4951821 4956004 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01001280001 4951821 4956004 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01001280001 4951821 4956004 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01001280001 4951821 4956004 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01011330001 8616820 8618617 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01022116001 16711209 16721450 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01022116001 16711209 16721450 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01022116001 16711209 16721450 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01022116001 16711209 16721450 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01028891001 17775849 17795068 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01011548001 12445349 12445839 GSVIVG01009001001 4159692 4169330 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01009001001 4159692 4169330 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01025083001 4646395 4653263 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. IEA GO:0004364 glutathione transferase activity GSVIVG01024102001 1043474 1048736 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024102001 1043474 1048736 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030266001 9710700 9718503 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030266001 9710700 9718503 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01030266001 9710700 9718503 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01019748001 2935651 2939145 GO:0006164 purine nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019748001 2935651 2939145 GO:0006177 GMP biosynthetic process The chemical reactions and pathways resulting in the formation of GMP, guanosine monophosphate. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019748001 2935651 2939145 GO:0006529 asparagine biosynthetic process The chemical reactions and pathways resulting in the formation of asparagine, 2-amino-3-carbamoylpropanoic acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019748001 2935651 2939145 GO:0006164 purine nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. IEA Catalysis of the reaction: ATP + xanthosine 5'-phosphate + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate. IEA GO:0003922 GMP synthase (glutamine-hydrolyzing) activity GSVIVG01019748001 2935651 2939145 GO:0006177 GMP biosynthetic process The chemical reactions and pathways resulting in the formation of GMP, guanosine monophosphate. IEA Catalysis of the reaction: ATP + xanthosine 5'-phosphate + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate. IEA GO:0003922 GMP synthase (glutamine-hydrolyzing) activity GSVIVG01019748001 2935651 2939145 GO:0006529 asparagine biosynthetic process The chemical reactions and pathways resulting in the formation of asparagine, 2-amino-3-carbamoylpropanoic acid. IEA Catalysis of the reaction: ATP + xanthosine 5'-phosphate + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate. IEA GO:0003922 GMP synthase (glutamine-hydrolyzing) activity GSVIVG01019748001 2935651 2939145 GO:0006164 purine nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. IEA Catalysis of the reaction: ATP + L-aspartate + L-glutamine = AMP + diphosphate + L-asparagine + L-glutamate. IEA GO:0004066 asparagine synthase (glutamine-hydrolyzing) activity GSVIVG01019748001 2935651 2939145 GO:0006177 GMP biosynthetic process The chemical reactions and pathways resulting in the formation of GMP, guanosine monophosphate. IEA Catalysis of the reaction: ATP + L-aspartate + L-glutamine = AMP + diphosphate + L-asparagine + L-glutamate. IEA GO:0004066 asparagine synthase (glutamine-hydrolyzing) activity GSVIVG01019748001 2935651 2939145 GO:0006529 asparagine biosynthetic process The chemical reactions and pathways resulting in the formation of asparagine, 2-amino-3-carbamoylpropanoic acid. IEA Catalysis of the reaction: ATP + L-aspartate + L-glutamine = AMP + diphosphate + L-asparagine + L-glutamate. IEA GO:0004066 asparagine synthase (glutamine-hydrolyzing) activity GSVIVG01019748001 2935651 2939145 GO:0006164 purine nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019748001 2935651 2939145 GO:0006177 GMP biosynthetic process The chemical reactions and pathways resulting in the formation of GMP, guanosine monophosphate. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019748001 2935651 2939145 GO:0006529 asparagine biosynthetic process The chemical reactions and pathways resulting in the formation of asparagine, 2-amino-3-carbamoylpropanoic acid. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023857001 2934474 2935485 GO:0009664 plant-type cell wall organization A process that results in the assembly and arrangement of constituent parts of the cellulose and pectin-containing cell wall, or in the disassembly of the cellulose and pectin-containing cell wall. This process is carried out at the cellular level. An example of this process is found in Arabidopsis thaliana. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA GSVIVG01000145001 15629882 15632921 GSVIVG01000567001 6994567 7007375 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01000567001 6994567 7007375 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01000567001 6994567 7007375 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01000567001 6994567 7007375 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01025812001 11596355 11597548 GSVIVG01022343001 18725161 18730916 GSVIVG01011122001 1402685 1405099 GSVIVG01011990001 2371303 2371826 GSVIVG01005088001 14414646 14416964 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01005088001 14414646 14416964 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01005088001 14414646 14416964 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01005088001 14414646 14416964 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01016662001 203646 204831 GSVIVG01010415001 20362037 20362090 GSVIVG01025733001 12499386 12514157 Catalysis of the reaction: an acyl phosphate + H2O = a carboxylate + phosphate. IEA GO:0003998 acylphosphatase activity GSVIVG01001651001 21800137 21802705 GSVIVG01031541001 17360315 17361266 GSVIVG01035767001 4133940 4146561 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01035767001 4133940 4146561 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035767001 4133940 4146561 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01035767001 4133940 4146561 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01016751001 901025 904399 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030345001 8408536 8411502 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01028157001 4282787 4297120 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01028157001 4282787 4297120 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01026008001 25905324 25934916 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Catalysis of the reaction: ATP + AMP = 2 ADP. IEA GO:0004017 adenylate kinase activity GSVIVG01026008001 25905324 25934916 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026008001 25905324 25934916 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a phosphate group (acceptor). IEA GO:0016776 phosphotransferase activity, phosphate group as acceptor GSVIVG01026008001 25905324 25934916 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Catalysis of the reaction: ATP + nucleoside monophosphate = ADP + nucleoside diphosphate. IEA GO:0019201 nucleotide kinase activity GSVIVG01026008001 25905324 25934916 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate. IEA GO:0019205 nucleobase, nucleoside, nucleotide kinase activity GSVIVG01025988001 26227551 26229054 GSVIVG01015966001 16377994 16380137 GSVIVG01034397001 16839326 16841718 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01034397001 16839326 16841718 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01014117001 535127 547165 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014117001 535127 547165 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014117001 535127 547165 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014117001 535127 547165 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014117001 535127 547165 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024890001 6214898 6216660 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024890001 6214898 6216660 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024890001 6214898 6216660 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024890001 6214898 6216660 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01024890001 6214898 6216660 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01024890001 6214898 6216660 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01024890001 6214898 6216660 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024890001 6214898 6216660 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024890001 6214898 6216660 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024890001 6214898 6216660 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01024890001 6214898 6216660 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01024890001 6214898 6216660 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01024890001 6214898 6216660 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024890001 6214898 6216660 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024890001 6214898 6216660 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033355001 21253140 21259663 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01033355001 21253140 21259663 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01033355001 21253140 21259663 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01033355001 21253140 21259663 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033355001 21253140 21259663 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032867001 112343 116068 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032867001 112343 116068 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032867001 112343 116068 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032867001 112343 116068 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032867001 112343 116068 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01032867001 112343 116068 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01032867001 112343 116068 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01032867001 112343 116068 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01026468001 23068714 23069602 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01014319001 2600506 2605072 Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01014319001 2600506 2605072 Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01025272001 2557957 2559971 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01025272001 2557957 2559971 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01008217001 4537833 4549604 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01008217001 4537833 4549604 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030942001 19450017 19528533 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m). IEA GO:0003910 DNA ligase (ATP) activity GSVIVG01030942001 19450017 19528533 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m). IEA GO:0003910 DNA ligase (ATP) activity GSVIVG01030942001 19450017 19528533 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m). IEA GO:0003910 DNA ligase (ATP) activity GSVIVG01030942001 19450017 19528533 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030942001 19450017 19528533 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030942001 19450017 19528533 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020729001 2607131 2619559 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01020729001 2607131 2619559 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01020729001 2607131 2619559 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01020729001 2607131 2619559 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020729001 2607131 2619559 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008753001 1714247 1715403 GSVIVG01003891001 13213826 13218535 GSVIVG01029350001 15022818 15030555 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013589001 21217761 21225681 GSVIVG01014073001 147060 149556 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01014073001 147060 149556 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01003485001 10672930 10675742 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01009476001 8692168 8698050 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01009476001 8692168 8698050 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01031356001 86812 92261 GSVIVG01023250001 20566763 20575968 GSVIVG01035326001 480827 497305 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008840001 2662828 2675878 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028218001 4692918 4701213 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01028218001 4692918 4701213 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028218001 4692918 4701213 Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01028218001 4692918 4701213 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01006320001 24878471 24885667 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01006320001 24878471 24885667 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01006320001 24878471 24885667 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006320001 24878471 24885667 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006320001 24878471 24885667 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01006320001 24878471 24885667 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01022560001 5060853 5062231 GSVIVG01005081001 14349798 14351511 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01011972001 2495104 2505305 GSVIVG01026836001 20097785 20098365 GSVIVG01030815001 16580076 16581881 GSVIVG01019908001 4398446 4399315 GSVIVG01023641001 8348104 8349655 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035410001 1090828 1092862 GSVIVG01000254001 20590459 20591957 GSVIVG01011594001 6129834 6135868 GSVIVG01014414001 3557789 3561705 GSVIVG01001792001 3256691 3257191 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016471 vacuolar proton-transporting V-type ATPase complex A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01010444001 20663797 20665821 GSVIVG01024867001 6360236 6368169 Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity. IEA GO:0004721 phosphoprotein phosphatase activity GSVIVG01024867001 6360236 6368169 Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01024867001 6360236 6368169 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01034449001 16063349 16064609 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: 3-alpha(S)-strictosidine = tryptamine + secologanin. IEA GO:0016844 strictosidine synthase activity GSVIVG01024467001 2987080 3010634 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01024467001 2987080 3010634 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01008745001 1670374 1677096 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01008745001 1670374 1677096 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008745001 1670374 1677096 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. IEA GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GSVIVG01008745001 1670374 1677096 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species. IEA GO:0031418 L-ascorbic acid binding GSVIVG01011471001 29910075 29915076 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01011471001 29910075 29915076 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01011471001 29910075 29915076 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01011471001 29910075 29915076 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010168001 16683140 16690231 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01010168001 16683140 16690231 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01010168001 16683140 16690231 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01010168001 16683140 16690231 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01010168001 16683140 16690231 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01010168001 16683140 16690231 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01010168001 16683140 16690231 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01010168001 16683140 16690231 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01010168001 16683140 16690231 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01010168001 16683140 16690231 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01026384001 15400102 15401943 GO:0006519 cellular amino acid and derivative metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026384001 15400102 15401943 GO:0019752 carboxylic acid metabolic process The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026384001 15400102 15401943 GO:0006519 cellular amino acid and derivative metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells. IEA Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. IEA GO:0016831 carboxy-lyase activity GSVIVG01026384001 15400102 15401943 GO:0019752 carboxylic acid metabolic process The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). IEA Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. IEA GO:0016831 carboxy-lyase activity GSVIVG01026384001 15400102 15401943 GO:0006519 cellular amino acid and derivative metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01026384001 15400102 15401943 GO:0019752 carboxylic acid metabolic process The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01011560001 6469513 6470724 GO:0006566 threonine metabolic process The chemical reactions and pathways involving threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins. IEA Catalysis of the reaction: ATP + L-homoserine = ADP + O-phospho-L-homoserine. IEA GO:0004413 homoserine kinase activity GSVIVG01011560001 6469513 6470724 GO:0006566 threonine metabolic process The chemical reactions and pathways involving threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012053001 1770545 1774624 GSVIVG01019570001 1674271 1678031 GSVIVG01037285001 16485012 16486199 GSVIVG01007792001 8977900 8986870 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01014668001 8370486 8373796 GSVIVG01018734001 20310936 20311643 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01037870001 6905702 6914851 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01037870001 6905702 6914851 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01037870001 6905702 6914851 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. IEA GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GSVIVG01037870001 6905702 6914851 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species. IEA GO:0031418 L-ascorbic acid binding GSVIVG01025871001 10959453 10966551 GSVIVG01000731001 273455 276429 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01024128001 890779 895141 GSVIVG01016714001 557281 561886 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016714001 557281 561886 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016714001 557281 561886 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0010181 FMN binding GSVIVG01016714001 557281 561886 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0010181 FMN binding GSVIVG01016714001 557281 561886 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016714001 557281 561886 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01018349001 10691699 10694737 GSVIVG01031134001 1838888 1855098 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031134001 1838888 1855098 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01030127001 10077599 10084191 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01037066001 8220124 8227724 Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01021899001 5851403 5851651 GSVIVG01024278001 503395 504575 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01024278001 503395 504575 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01024278001 503395 504575 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01024278001 503395 504575 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01018131001 6846824 6849103 GSVIVG01023336001 19630555 19638518 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000512001 13298067 13301005 GSVIVG01010921001 15685410 15689385 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01010921001 15685410 15689385 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01010921001 15685410 15689385 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01010921001 15685410 15689385 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01010921001 15685410 15689385 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01010921001 15685410 15689385 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01035113001 1558829 1560136 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035113001 1558829 1560136 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain. IEA GO:0004177 aminopeptidase activity GSVIVG01038790001 980511 981988 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01038790001 980511 981988 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01038790001 980511 981988 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01038790001 980511 981988 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01038790001 980511 981988 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of potassium ions (K+) from one side of a membrane to the other. IEA GO:0015079 potassium ion transmembrane transporter activity GSVIVG01038790001 980511 981988 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of potassium ions (K+) from one side of a membrane to the other. IEA GO:0015079 potassium ion transmembrane transporter activity GSVIVG01009820001 11539928 11541211 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018153001 13836279 13839409 GO:0006464 protein modification process The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). IEA GSVIVG01018153001 13836279 13839409 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GSVIVG01035963001 6537828 6551330 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035963001 6537828 6551330 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01035963001 6537828 6551330 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with a ribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to ribose. IEA GO:0032549 ribonucleoside binding GSVIVG01012200001 593578 596330 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01038576001 21751205 21756610 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005801 cis-Golgi network The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum. IEA GSVIVG01038576001 21751205 21756610 GO:0006888 ER to Golgi vesicle-mediated transport The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi. IEA GO:0005801 cis-Golgi network The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum. IEA GSVIVG01036076001 21016307 21019097 GSVIVG01007210001 30866562 30873017 GSVIVG01032492001 27849550 27871552 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01032492001 27849550 27871552 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032492001 27849550 27871552 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01012829001 5843910 5869510 GSVIVG01006111001 41671706 41672610 GSVIVG01033611001 19317798 19319829 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: 3-alpha(S)-strictosidine = tryptamine + secologanin. IEA GO:0016844 strictosidine synthase activity GSVIVG01019388001 243559 247500 GSVIVG01009823001 11561350 11567821 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01009823001 11561350 11567821 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01016047001 17898816 17903178 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01016047001 17898816 17903178 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01011926001 2954243 2955469 GSVIVG01025351001 1615854 1621944 GO:0006464 protein modification process The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025351001 1615854 1621944 GO:0009107 lipoate biosynthetic process The chemical reactions and pathways resulting in the formation of lipoate, 1,2-dithiolane-3-pentanoate, the anion derived from lipoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025351001 1615854 1621944 GO:0006464 protein modification process The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of an octanoyl (CH3-[CH2]6-CO-) group to an acceptor molecule. IEA GO:0016415 octanoyltransferase activity GSVIVG01025351001 1615854 1621944 GO:0009107 lipoate biosynthetic process The chemical reactions and pathways resulting in the formation of lipoate, 1,2-dithiolane-3-pentanoate, the anion derived from lipoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of an octanoyl (CH3-[CH2]6-CO-) group to an acceptor molecule. IEA GO:0016415 octanoyltransferase activity GSVIVG01013771001 7736722 7740705 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01013771001 7736722 7740705 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01013771001 7736722 7740705 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01013771001 7736722 7740705 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01013771001 7736722 7740705 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01013771001 7736722 7740705 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01033552001 19813364 19821168 GSVIVG01016396001 4233610 4234792 GSVIVG01022508001 4189722 4193333 GSVIVG01029555001 21641396 21646562 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01029555001 21641396 21646562 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01029555001 21641396 21646562 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01029555001 21641396 21646562 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01029555001 21641396 21646562 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01029555001 21641396 21646562 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01029555001 21641396 21646562 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01029555001 21641396 21646562 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01029555001 21641396 21646562 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01029555001 21641396 21646562 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01029555001 21641396 21646562 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01029555001 21641396 21646562 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01001965001 5851478 5864139 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008912001 3340662 3348874 GSVIVG01018330001 10933762 10942754 GSVIVG01033737001 18224639 18225422 GSVIVG01026056001 25210556 25216882 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01020947001 16656212 16665523 GSVIVG01033491001 20273743 20284076 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01033491001 20273743 20284076 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01015042001 683148 685602 GSVIVG01035327001 498015 503312 GO:0006450 regulation of translational fidelity Any process that modulates the ability of the translational apparatus to interpret the genetic code. IEA GSVIVG01029013001 10720370 10724976 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01029013001 10720370 10724976 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01029013001 10720370 10724976 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029013001 10720370 10724976 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029013001 10720370 10724976 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029013001 10720370 10724976 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029013001 10720370 10724976 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01029013001 10720370 10724976 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01032871001 98017 101708 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01032871001 98017 101708 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01032871001 98017 101708 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01032871001 98017 101708 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01015468001 3972559 3974547 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01001117001 22739459 22746440 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01001117001 22739459 22746440 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01001117001 22739459 22746440 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01012767001 23577229 23587485 GSVIVG01017735001 3006672 3013146 GSVIVG01025552001 14093259 14106587 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01025552001 14093259 14106587 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01025552001 14093259 14106587 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01025552001 14093259 14106587 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025552001 14093259 14106587 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011685001 5131460 5135169 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005875 microtubule associated complex Any multimeric complex connected to a microtubule. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01007970001 7067454 7068643 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01007970001 7067454 7068643 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01017031001 3626732 3638583 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01017031001 3626732 3638583 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01004118001 15031991 15032185 GSVIVG01015664001 15200149 15202458 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01001835001 26200079 26207129 GSVIVG01027249001 17636157 17636990 GSVIVG01009694001 10526522 10528847 GSVIVG01028237001 4856398 4865291 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GSVIVG01030822001 16884546 16885871 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01028048001 3435385 3438472 GSVIVG01001984001 6053970 6060010 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01001984001 6053970 6060010 Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01013058001 8991157 9003680 GSVIVG01017032001 3640965 3646623 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017032001 3640965 3646623 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017032001 3640965 3646623 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017032001 3640965 3646623 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015685001 15582922 15585234 GSVIVG01025099001 4509264 4517165 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025099001 4509264 4517165 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025099001 4509264 4517165 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025099001 4509264 4517165 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate in the presence of single- or double-stranded DNA; drives another reaction. IEA GO:0008094 DNA-dependent ATPase activity GSVIVG01025099001 4509264 4517165 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01008510001 1246492 1250567 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the reaction: ATP + L-citrulline + L-aspartate = AMP + diphosphate + (N(omega)-L-arginino)succinate. IEA GO:0004055 argininosuccinate synthase activity GSVIVG01008510001 1246492 1250567 GO:0006526 arginine biosynthetic process The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid. IEA Catalysis of the reaction: ATP + L-citrulline + L-aspartate = AMP + diphosphate + (N(omega)-L-arginino)succinate. IEA GO:0004055 argininosuccinate synthase activity GSVIVG01008510001 1246492 1250567 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the reaction: ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. IEA GO:0004618 phosphoglycerate kinase activity GSVIVG01008510001 1246492 1250567 GO:0006526 arginine biosynthetic process The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid. IEA Catalysis of the reaction: ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. IEA GO:0004618 phosphoglycerate kinase activity GSVIVG01008510001 1246492 1250567 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008510001 1246492 1250567 GO:0006526 arginine biosynthetic process The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031474001 18156115 18159944 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031474001 18156115 18159944 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031474001 18156115 18159944 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031474001 18156115 18159944 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031474001 18156115 18159944 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031474001 18156115 18159944 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031474001 18156115 18159944 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01031474001 18156115 18159944 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01031474001 18156115 18159944 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01031474001 18156115 18159944 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031474001 18156115 18159944 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031474001 18156115 18159944 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01035795001 4419327 4428625 GSVIVG01027437001 16729944 16734154 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: ADP-glucose + (1,4)-alpha-D-glucosyl(n) = ADP + (1,4)-alpha-D-glucosyl(n+1). IEA GO:0009011 starch synthase activity GSVIVG01027437001 16729944 16734154 GO:0009250 glucan biosynthetic process The chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues. IEA Catalysis of the reaction: ADP-glucose + (1,4)-alpha-D-glucosyl(n) = ADP + (1,4)-alpha-D-glucosyl(n+1). IEA GO:0009011 starch synthase activity GSVIVG01019566001 1653587 1657804 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019566001 1653587 1657804 GO:0009725 response to hormone stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019566001 1653587 1657804 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019566001 1653587 1657804 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01019566001 1653587 1657804 GO:0009725 response to hormone stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01019566001 1653587 1657804 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01009409001 8092084 8129064 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Interacting selectively and non-covalently with chromatin, the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase. IEA GO:0003682 chromatin binding GSVIVG01009409001 8092084 8129064 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with chromatin, the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase. IEA GO:0003682 chromatin binding GSVIVG01032357001 26662967 26666422 GSVIVG01022314001 18418409 18419690 GSVIVG01001450001 21118411 21120915 GSVIVG01034644001 13517388 13518180 GSVIVG01014140001 730232 751954 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014140001 730232 751954 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014140001 730232 751954 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014140001 730232 751954 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030604001 7080961 7091719 GSVIVG01022582001 5432198 5454858 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin. IEA GO:0004221 ubiquitin thiolesterase activity GSVIVG01012151001 1002540 1009582 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with damaged DNA. IEA GO:0003684 damaged DNA binding GSVIVG01012151001 1002540 1009582 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with damaged DNA. IEA GO:0003684 damaged DNA binding GSVIVG01012151001 1002540 1009582 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with damaged DNA. IEA GO:0003684 damaged DNA binding GSVIVG01012151001 1002540 1009582 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and primer. IEA GO:0003887 DNA-directed DNA polymerase activity GSVIVG01012151001 1002540 1009582 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and primer. IEA GO:0003887 DNA-directed DNA polymerase activity GSVIVG01012151001 1002540 1009582 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and primer. IEA GO:0003887 DNA-directed DNA polymerase activity GSVIVG01012151001 1002540 1009582 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01012151001 1002540 1009582 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01012151001 1002540 1009582 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01012151001 1002540 1009582 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a carboxyl group (acceptor). IEA GO:0016774 phosphotransferase activity, carboxyl group as acceptor GSVIVG01012151001 1002540 1009582 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a carboxyl group (acceptor). IEA GO:0016774 phosphotransferase activity, carboxyl group as acceptor GSVIVG01012151001 1002540 1009582 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a carboxyl group (acceptor). IEA GO:0016774 phosphotransferase activity, carboxyl group as acceptor GSVIVG01032812001 565013 571193 GSVIVG01010584001 16346363 16348042 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010584001 16346363 16348042 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010584001 16346363 16348042 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01010584001 16346363 16348042 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01014860001 10712859 10726195 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01013418001 593668 597777 GSVIVG01034613001 14375757 14408452 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01019471001 899832 914539 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01019471001 899832 914539 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01019471001 899832 914539 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019471001 899832 914539 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019471001 899832 914539 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01019471001 899832 914539 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01019471001 899832 914539 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01019471001 899832 914539 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01019471001 899832 914539 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01019471001 899832 914539 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01023009001 16971145 16977848 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01005815001 22060971 22065024 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01015164001 1479026 1486976 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01023918001 2491565 2500092 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023918001 2491565 2500092 GO:0006419 alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023918001 2491565 2500092 GO:0043039 tRNA aminoacylation The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023918001 2491565 2500092 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01023918001 2491565 2500092 GO:0006419 alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01023918001 2491565 2500092 GO:0043039 tRNA aminoacylation The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01023918001 2491565 2500092 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala). IEA GO:0004813 alanine-tRNA ligase activity GSVIVG01023918001 2491565 2500092 GO:0006419 alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala). IEA GO:0004813 alanine-tRNA ligase activity GSVIVG01023918001 2491565 2500092 GO:0043039 tRNA aminoacylation The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala). IEA GO:0004813 alanine-tRNA ligase activity GSVIVG01023918001 2491565 2500092 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023918001 2491565 2500092 GO:0006419 alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023918001 2491565 2500092 GO:0043039 tRNA aminoacylation The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023918001 2491565 2500092 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances via a carbon-oxygen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate, to form aminoacyl-tRNA or a related compound. IEA GO:0016876 ligase activity, forming aminoacyl-tRNA and related compounds GSVIVG01023918001 2491565 2500092 GO:0006419 alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances via a carbon-oxygen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate, to form aminoacyl-tRNA or a related compound. IEA GO:0016876 ligase activity, forming aminoacyl-tRNA and related compounds GSVIVG01023918001 2491565 2500092 GO:0043039 tRNA aminoacylation The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances via a carbon-oxygen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate, to form aminoacyl-tRNA or a related compound. IEA GO:0016876 ligase activity, forming aminoacyl-tRNA and related compounds GSVIVG01026642001 20801267 20803199 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01011472001 29916400 29925511 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01011472001 29916400 29925511 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01014709001 8884922 8891239 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01017760001 3197070 3199170 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01021410001 5051146 5052331 GSVIVG01000066001 3196104 3197088 GO:0006566 threonine metabolic process The chemical reactions and pathways involving threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: ATP + L-homoserine = ADP + O-phospho-L-homoserine. IEA GO:0004413 homoserine kinase activity GSVIVG01000066001 3196104 3197088 GO:0006566 threonine metabolic process The chemical reactions and pathways involving threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000066001 3196104 3197088 GO:0006566 threonine metabolic process The chemical reactions and pathways involving threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with manganese (Mn) ions. IEA GO:0030145 manganese ion binding GSVIVG01000066001 3196104 3197088 GO:0006566 threonine metabolic process The chemical reactions and pathways involving threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Functions in the storage of nutritious substrates. IEA GO:0045735 nutrient reservoir activity GSVIVG01017077001 4015539 4019331 GSVIVG01013263001 6113176 6119879 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01013263001 6113176 6119879 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01027994001 3060928 3067386 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA GSVIVG01036074001 21025800 21029434 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. IEA GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GSVIVG01036545001 23285988 23293022 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036545001 23285988 23293022 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01035438001 1262053 1262217 GSVIVG01027060001 18246689 18249604 GSVIVG01022435001 2984134 2997026 GSVIVG01019595001 1827632 1830534 GSVIVG01031025001 21079334 21103476 GSVIVG01017826001 3820377 3827378 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01036313001 3701204 3702708 Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01036313001 3701204 3702708 Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01031844001 4819002 4820340 GSVIVG01015003001 348626 373105 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005801 cis-Golgi network The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum. IEA GSVIVG01015003001 348626 373105 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01018693001 11016213 11018174 GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014220001 1617111 1624853 GSVIVG01016749001 889436 894015 GO:0015969 guanosine tetraphosphate metabolic process The chemical reactions and pathways involving guanine tetraphosphate (5'-ppGpp-3'), a derivative of guanine riboside with four phosphates. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01011692001 5088214 5089383 GSVIVG01001831001 26169654 26172852 GSVIVG01035892001 5409058 5416309 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01007857001 8299160 8313462 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion. IEA GO:0004806 triglyceride lipase activity GSVIVG01016587001 2602004 2603197 GSVIVG01022267001 18026962 18035773 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01022267001 18026962 18035773 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids. IEA GO:0004518 nuclease activity GSVIVG01022267001 18026962 18035773 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029772001 14453688 14454970 GSVIVG01027429001 16814247 16816980 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01027429001 16814247 16816980 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01033039001 25263248 25273085 GSVIVG01002194001 33211411 33219637 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion. IEA GO:0004806 triglyceride lipase activity GSVIVG01021000001 15607720 15609012 GSVIVG01008630001 286804 292529 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01008630001 286804 292529 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01008630001 286804 292529 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01008630001 286804 292529 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01008630001 286804 292529 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01008630001 286804 292529 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01008630001 286804 292529 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008630001 286804 292529 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008630001 286804 292529 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008630001 286804 292529 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008630001 286804 292529 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008630001 286804 292529 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01030233001 10148960 10154721 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA GSVIVG01025354001 1584405 1589249 GSVIVG01024123001 915230 915499 GSVIVG01010404001 20229630 20231128 GSVIVG01010473001 20879331 20883898 GSVIVG01020337001 21142903 21143583 GSVIVG01032573001 28483253 28485882 Catalysis of the removal of a phosphate group from phosphorylated myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol. IEA GO:0004437 inositol or phosphatidylinositol phosphatase activity GSVIVG01025567001 13991651 13999804 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01024968001 5622668 5625801 GSVIVG01011054001 1951233 1954528 GSVIVG01037657001 6601791 6614339 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051539 4 iron, 4 sulfur cluster binding GSVIVG01026928001 19336280 19337354 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01026928001 19336280 19337354 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01009576001 9566550 9570199 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01009576001 9566550 9570199 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01009576001 9566550 9570199 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01009576001 9566550 9570199 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01009576001 9566550 9570199 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009576001 9566550 9570199 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009576001 9566550 9570199 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01009576001 9566550 9570199 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01010526001 21477711 21484817 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010526001 21477711 21484817 GO:0019752 carboxylic acid metabolic process The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010526001 21477711 21484817 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. IEA GO:0016831 carboxy-lyase activity GSVIVG01010526001 21477711 21484817 GO:0019752 carboxylic acid metabolic process The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). IEA Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. IEA GO:0016831 carboxy-lyase activity GSVIVG01010526001 21477711 21484817 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01010526001 21477711 21484817 GO:0019752 carboxylic acid metabolic process The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01014802001 9975327 9975818 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01020842001 1179799 1181100 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01029326001 14377189 14378419 GSVIVG01007007001 29699647 29704648 GSVIVG01024077001 1292143 1293614 GSVIVG01024685001 7765753 7771747 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01015062001 787353 794950 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01015062001 787353 794950 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01023132001 22257008 22261407 GSVIVG01034760001 9143294 9146110 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the transfer of copper (Cu) ions from one side of a membrane to the other. IEA GO:0005375 copper ion transmembrane transporter activity GSVIVG01034760001 9143294 9146110 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the transfer of copper (Cu) ions from one side of a membrane to the other. IEA GO:0005375 copper ion transmembrane transporter activity GSVIVG01034760001 9143294 9146110 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the transfer of copper (Cu) ions from one side of a membrane to the other. IEA GO:0005375 copper ion transmembrane transporter activity GSVIVG01034760001 9143294 9146110 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01034760001 9143294 9146110 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01034760001 9143294 9146110 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01034760001 9143294 9146110 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01034760001 9143294 9146110 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01034760001 9143294 9146110 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01034760001 9143294 9146110 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01034760001 9143294 9146110 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01034760001 9143294 9146110 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01022356001 18957732 18963872 GO:0006081 cellular aldehyde metabolic process The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells. IEA Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+. IEA GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity GSVIVG01022356001 18957732 18963872 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+. IEA GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity GSVIVG01022356001 18957732 18963872 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+. IEA GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity GSVIVG01022356001 18957732 18963872 GO:0006081 cellular aldehyde metabolic process The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022356001 18957732 18963872 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022356001 18957732 18963872 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01003825001 20459877 20462249 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: 3-alpha(S)-strictosidine = tryptamine + secologanin. IEA GO:0016844 strictosidine synthase activity GSVIVG01006330001 24925396 24935982 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01004583001 39131072 39131859 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01004583001 39131072 39131859 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01029594001 20967418 20968579 GSVIVG01029291001 17422083 17431472 GO:0046836 glycolipid transport The directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Enables the directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of, within or between cells. IEA GO:0017089 glycolipid transporter activity GSVIVG01029291001 17422083 17431472 GO:0046836 glycolipid transport The directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a glycolipid, any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic moiety such as an acylglycerol, a sphingoid, a ceramide (N-acylsphingoid) or a prenyl phosphate. IEA GO:0051861 glycolipid binding GSVIVG01025493001 344489 349182 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01025493001 344489 349182 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01025493001 344489 349182 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01025493001 344489 349182 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01037470001 13131070 13132077 GSVIVG01008897001 3233803 3234804 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01008897001 3233803 3234804 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01036270001 7688080 7746051 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01004121001 15046552 15059061 GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01004121001 15046552 15059061 GO:0006573 valine metabolic process The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01004121001 15046552 15059061 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01004121001 15046552 15059061 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01004121001 15046552 15059061 GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. IEA Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+. IEA GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity GSVIVG01004121001 15046552 15059061 GO:0006573 valine metabolic process The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid. IEA Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+. IEA GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity GSVIVG01004121001 15046552 15059061 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+. IEA GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity GSVIVG01004121001 15046552 15059061 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+. IEA GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity GSVIVG01004121001 15046552 15059061 GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01004121001 15046552 15059061 GO:0006573 valine metabolic process The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01004121001 15046552 15059061 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01004121001 15046552 15059061 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01004121001 15046552 15059061 GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01004121001 15046552 15059061 GO:0006573 valine metabolic process The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01004121001 15046552 15059061 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01004121001 15046552 15059061 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01004121001 15046552 15059061 GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. IEA Catalysis of the reaction: 3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH + H+. IEA GO:0008442 3-hydroxyisobutyrate dehydrogenase activity GSVIVG01004121001 15046552 15059061 GO:0006573 valine metabolic process The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid. IEA Catalysis of the reaction: 3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH + H+. IEA GO:0008442 3-hydroxyisobutyrate dehydrogenase activity GSVIVG01004121001 15046552 15059061 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH + H+. IEA GO:0008442 3-hydroxyisobutyrate dehydrogenase activity GSVIVG01004121001 15046552 15059061 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH + H+. IEA GO:0008442 3-hydroxyisobutyrate dehydrogenase activity GSVIVG01004121001 15046552 15059061 GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01004121001 15046552 15059061 GO:0006573 valine metabolic process The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01004121001 15046552 15059061 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01004121001 15046552 15059061 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01015283001 2377698 2381398 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01015283001 2377698 2381398 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01015283001 2377698 2381398 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01015283001 2377698 2381398 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01015283001 2377698 2381398 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027658001 14555852 14559875 GSVIVG01017922001 4728528 4730147 GO:0009296 flagellum assembly The assembly of a flagellum. In bacteria, this is a whiplike motility appendage present on the surface of some species; in eukaryotes, flagella are threadlike protoplasmic extensions used to propel flagellates and sperm. Flagella are composed of flagellin and have the same basic structure as cilia but are longer in proportion to the cell and present in much smaller numbers. IEA GO:0009424 bacterial-type flagellum hook The portion of the flagellum that connects the filament to the basal body. Examples of this component are found in bacteria. IEA Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate. IEA GO:0003774 motor activity GSVIVG01002351001 34326056 34329084 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01002351001 34326056 34329084 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01034212001 14388048 14398340 GSVIVG01029758001 14269590 14294690 GSVIVG01001999001 6170317 6176370 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01001999001 6170317 6176370 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028109001 3872512 3873999 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA GSVIVG01035843001 4803496 4813915 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01035843001 4803496 4813915 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01035843001 4803496 4813915 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035843001 4803496 4813915 Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01019899001 4333158 4334766 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01032482001 27784400 27784633 GSVIVG01000993001 11222357 11224312 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01019506001 1193761 1198827 GSVIVG01021158001 1989784 1990832 GSVIVG01037663001 6659403 6661175 GSVIVG01009693001 10523646 10524149 GSVIVG01012020001 2136955 2137266 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012020001 2136955 2137266 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01012020001 2136955 2137266 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01030034001 9017193 9022269 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025465001 596521 630342 GSVIVG01037228001 27675110 27678094 GSVIVG01020226001 8851250 8851668 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01020226001 8851250 8851668 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01029041001 11227881 11228306 GSVIVG01010347001 19699207 19700709 GSVIVG01033979001 16134520 16135476 GSVIVG01030675001 13377626 13379471 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01008167001 5154403 5159799 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01008167001 5154403 5159799 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01024746001 7246408 7248938 Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor). IEA GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups GSVIVG01005639001 20788253 20792715 GSVIVG01016702001 473899 474745 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Enables the directed movement of acyl groups into, out of, within or between cells. IEA GO:0000036 acyl carrier activity GSVIVG01016702001 473899 474745 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. IEA GO:0048037 cofactor binding GSVIVG01034984001 681456 682628 GO:0001539 ciliary or flagellar motility Cell motility due to movement of cilia or flagella. IEA GO:0009428 bacterial-type flagellum basal body, distal rod, P ring One of the rings of the flagellar basal body; anchors the basal body to the peptidoglycan layer. Examples of this component are found in bacteria. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01034984001 681456 682628 GO:0001539 ciliary or flagellar motility Cell motility due to movement of cilia or flagella. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01034984001 681456 682628 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA GO:0009428 bacterial-type flagellum basal body, distal rod, P ring One of the rings of the flagellar basal body; anchors the basal body to the peptidoglycan layer. Examples of this component are found in bacteria. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01034984001 681456 682628 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01034984001 681456 682628 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009428 bacterial-type flagellum basal body, distal rod, P ring One of the rings of the flagellar basal body; anchors the basal body to the peptidoglycan layer. Examples of this component are found in bacteria. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01034984001 681456 682628 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01034984001 681456 682628 GO:0001539 ciliary or flagellar motility Cell motility due to movement of cilia or flagella. IEA GO:0009428 bacterial-type flagellum basal body, distal rod, P ring One of the rings of the flagellar basal body; anchors the basal body to the peptidoglycan layer. Examples of this component are found in bacteria. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01034984001 681456 682628 GO:0001539 ciliary or flagellar motility Cell motility due to movement of cilia or flagella. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01034984001 681456 682628 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA GO:0009428 bacterial-type flagellum basal body, distal rod, P ring One of the rings of the flagellar basal body; anchors the basal body to the peptidoglycan layer. Examples of this component are found in bacteria. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01034984001 681456 682628 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01034984001 681456 682628 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009428 bacterial-type flagellum basal body, distal rod, P ring One of the rings of the flagellar basal body; anchors the basal body to the peptidoglycan layer. Examples of this component are found in bacteria. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01034984001 681456 682628 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01034984001 681456 682628 GO:0001539 ciliary or flagellar motility Cell motility due to movement of cilia or flagella. IEA GO:0009428 bacterial-type flagellum basal body, distal rod, P ring One of the rings of the flagellar basal body; anchors the basal body to the peptidoglycan layer. Examples of this component are found in bacteria. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01034984001 681456 682628 GO:0001539 ciliary or flagellar motility Cell motility due to movement of cilia or flagella. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01034984001 681456 682628 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA GO:0009428 bacterial-type flagellum basal body, distal rod, P ring One of the rings of the flagellar basal body; anchors the basal body to the peptidoglycan layer. Examples of this component are found in bacteria. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01034984001 681456 682628 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01034984001 681456 682628 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009428 bacterial-type flagellum basal body, distal rod, P ring One of the rings of the flagellar basal body; anchors the basal body to the peptidoglycan layer. Examples of this component are found in bacteria. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01034984001 681456 682628 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01011065001 1859980 1871101 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01011065001 1859980 1871101 GO:0042765 GPI-anchor transamidase complex An enzyme complex which in humans and yeast consists of at least five proteins; for example, the complex contains GAA1, GPI8, PIG-S, PIG-U, and PIG-T in human, and Gaa1p, Gab1p, Gpi8p, Gpi16p, and Gpi17p in yeast. Catalyzes the posttranslational attachment of the carboxyl-terminus of a precursor protein to a GPI-anchor. IEA GSVIVG01012556001 3556198 3556666 GSVIVG01015299001 2482096 2488363 GSVIVG01009368001 7836872 7838406 GSVIVG01021518001 6481622 6482704 GSVIVG01009243001 6574841 6580376 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028079001 3651656 3656907 GO:0006606 protein import into nucleus The directed movement of a protein from the cytoplasm to the nucleus. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028079001 3651656 3656907 GO:0006606 protein import into nucleus The directed movement of a protein from the cytoplasm to the nucleus. IEA GO:0005643 nuclear pore Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028079001 3651656 3656907 GO:0006606 protein import into nucleus The directed movement of a protein from the cytoplasm to the nucleus. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028079001 3651656 3656907 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028079001 3651656 3656907 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005643 nuclear pore Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028079001 3651656 3656907 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028079001 3651656 3656907 GO:0006606 protein import into nucleus The directed movement of a protein from the cytoplasm to the nucleus. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01028079001 3651656 3656907 GO:0006606 protein import into nucleus The directed movement of a protein from the cytoplasm to the nucleus. IEA GO:0005643 nuclear pore Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01028079001 3651656 3656907 GO:0006606 protein import into nucleus The directed movement of a protein from the cytoplasm to the nucleus. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01028079001 3651656 3656907 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01028079001 3651656 3656907 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005643 nuclear pore Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01028079001 3651656 3656907 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01036477001 22547145 22550191 GO:0000162 tryptophan biosynthetic process The chemical reactions and pathways resulting in the formation of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; tryptophan is synthesized from chorismate via anthranilate. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01036477001 22547145 22550191 GO:0006568 tryptophan metabolic process The chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01036477001 22547145 22550191 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01036477001 22547145 22550191 GO:0000162 tryptophan biosynthetic process The chemical reactions and pathways resulting in the formation of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; tryptophan is synthesized from chorismate via anthranilate. IEA Catalysis of the reaction: L-serine + 1-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H2O. IEA GO:0004834 tryptophan synthase activity GSVIVG01036477001 22547145 22550191 GO:0006568 tryptophan metabolic process The chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid. IEA Catalysis of the reaction: L-serine + 1-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H2O. IEA GO:0004834 tryptophan synthase activity GSVIVG01036477001 22547145 22550191 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: L-serine + 1-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H2O. IEA GO:0004834 tryptophan synthase activity GSVIVG01036477001 22547145 22550191 GO:0000162 tryptophan biosynthetic process The chemical reactions and pathways resulting in the formation of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; tryptophan is synthesized from chorismate via anthranilate. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01036477001 22547145 22550191 GO:0006568 tryptophan metabolic process The chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01036477001 22547145 22550191 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01029854001 453661 461038 GSVIVG01011323001 8510938 8514910 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0016272 prefoldin complex A multisubunit chaperone that acts to delivers unfolded proteins to cytosolic chaperonin. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01025579001 13913010 13914150 GSVIVG01025253001 2678344 2680756 GSVIVG01011890001 3252820 3255454 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01029727001 13787525 13793030 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031922001 5429005 5431152 GSVIVG01018087001 6360869 6369087 GSVIVG01019830001 3722061 3723122 GSVIVG01017424001 8343101 8349165 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: diphosphate + H2O = 2 phosphate. IEA GO:0004427 inorganic diphosphatase activity GSVIVG01017424001 8343101 8349165 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of pyrophosphate, which generates a proton motive force. IEA GO:0009678 hydrogen-translocating pyrophosphatase activity GSVIVG01027835001 8390856 8397659 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01027835001 8390856 8397659 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01027835001 8390856 8397659 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01027835001 8390856 8397659 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006503001 42418385 42420545 GO:0009767 photosynthetic electron transport chain A process, occurring as part of photosynthesis, whereby light provides the energy for a series of electron carriers to operate together to transfer electrons and generate a transmembrane electrochemical gradient. IEA GO:0009521 photosystem A complex located in a photosynthetic membrane that consists of a photoreaction center associated with accessory pigments and electron carriers. Examples of this component are found in Arabidopsis thaliana and in photosynthetic bacterial and archaeal species. IEA Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. IEA GO:0016168 chlorophyll binding GSVIVG01006503001 42418385 42420545 GO:0009767 photosynthetic electron transport chain A process, occurring as part of photosynthesis, whereby light provides the energy for a series of electron carriers to operate together to transfer electrons and generate a transmembrane electrochemical gradient. IEA GO:0009523 photosystem II A photosystem that contains a pheophytin-quinone reaction center with associated accessory pigments and electron carriers. In cyanobacteria and chloroplasts, in the presence of light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone, whereas other photosynthetic bacteria carry out anoxygenic photosynthesis and oxidize other compounds to re-reduce the photoreaction center. IEA Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. IEA GO:0016168 chlorophyll binding GSVIVG01006503001 42418385 42420545 GO:0009767 photosynthetic electron transport chain A process, occurring as part of photosynthesis, whereby light provides the energy for a series of electron carriers to operate together to transfer electrons and generate a transmembrane electrochemical gradient. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. IEA GO:0016168 chlorophyll binding GSVIVG01006503001 42418385 42420545 GO:0009767 photosynthetic electron transport chain A process, occurring as part of photosynthesis, whereby light provides the energy for a series of electron carriers to operate together to transfer electrons and generate a transmembrane electrochemical gradient. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. IEA GO:0016168 chlorophyll binding GSVIVG01006503001 42418385 42420545 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009521 photosystem A complex located in a photosynthetic membrane that consists of a photoreaction center associated with accessory pigments and electron carriers. Examples of this component are found in Arabidopsis thaliana and in photosynthetic bacterial and archaeal species. IEA Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. IEA GO:0016168 chlorophyll binding GSVIVG01006503001 42418385 42420545 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009523 photosystem II A photosystem that contains a pheophytin-quinone reaction center with associated accessory pigments and electron carriers. In cyanobacteria and chloroplasts, in the presence of light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone, whereas other photosynthetic bacteria carry out anoxygenic photosynthesis and oxidize other compounds to re-reduce the photoreaction center. IEA Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. IEA GO:0016168 chlorophyll binding GSVIVG01006503001 42418385 42420545 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. IEA GO:0016168 chlorophyll binding GSVIVG01006503001 42418385 42420545 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. IEA GO:0016168 chlorophyll binding GSVIVG01006503001 42418385 42420545 GO:0019684 photosynthesis, light reaction The light reactions of photosynthesis, which take place in photosystems II and I. Light energy is harvested and used to power the transfer of electrons among a series of electron donors and acceptors. The final electron acceptor is NADP+, which is reduced to NADPH. NADPH generated from light reactions is used in sugar synthesis in dark reactions. Light reactions also generate a proton motive force across the thylakoid membrane, and the proton gradient is used to synthesize ATP. There are two chemical reactions involved in the light reactions: water oxidation in photosystem II, and NADP reduction in photosystem I. IEA GO:0009521 photosystem A complex located in a photosynthetic membrane that consists of a photoreaction center associated with accessory pigments and electron carriers. Examples of this component are found in Arabidopsis thaliana and in photosynthetic bacterial and archaeal species. IEA Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. IEA GO:0016168 chlorophyll binding GSVIVG01006503001 42418385 42420545 GO:0019684 photosynthesis, light reaction The light reactions of photosynthesis, which take place in photosystems II and I. Light energy is harvested and used to power the transfer of electrons among a series of electron donors and acceptors. The final electron acceptor is NADP+, which is reduced to NADPH. NADPH generated from light reactions is used in sugar synthesis in dark reactions. Light reactions also generate a proton motive force across the thylakoid membrane, and the proton gradient is used to synthesize ATP. There are two chemical reactions involved in the light reactions: water oxidation in photosystem II, and NADP reduction in photosystem I. IEA GO:0009523 photosystem II A photosystem that contains a pheophytin-quinone reaction center with associated accessory pigments and electron carriers. In cyanobacteria and chloroplasts, in the presence of light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone, whereas other photosynthetic bacteria carry out anoxygenic photosynthesis and oxidize other compounds to re-reduce the photoreaction center. IEA Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. IEA GO:0016168 chlorophyll binding GSVIVG01006503001 42418385 42420545 GO:0019684 photosynthesis, light reaction The light reactions of photosynthesis, which take place in photosystems II and I. Light energy is harvested and used to power the transfer of electrons among a series of electron donors and acceptors. The final electron acceptor is NADP+, which is reduced to NADPH. NADPH generated from light reactions is used in sugar synthesis in dark reactions. Light reactions also generate a proton motive force across the thylakoid membrane, and the proton gradient is used to synthesize ATP. There are two chemical reactions involved in the light reactions: water oxidation in photosystem II, and NADP reduction in photosystem I. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. IEA GO:0016168 chlorophyll binding GSVIVG01006503001 42418385 42420545 GO:0019684 photosynthesis, light reaction The light reactions of photosynthesis, which take place in photosystems II and I. Light energy is harvested and used to power the transfer of electrons among a series of electron donors and acceptors. The final electron acceptor is NADP+, which is reduced to NADPH. NADPH generated from light reactions is used in sugar synthesis in dark reactions. Light reactions also generate a proton motive force across the thylakoid membrane, and the proton gradient is used to synthesize ATP. There are two chemical reactions involved in the light reactions: water oxidation in photosystem II, and NADP reduction in photosystem I. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. IEA GO:0016168 chlorophyll binding GSVIVG01006503001 42418385 42420545 GO:0009767 photosynthetic electron transport chain A process, occurring as part of photosynthesis, whereby light provides the energy for a series of electron carriers to operate together to transfer electrons and generate a transmembrane electrochemical gradient. IEA GO:0009521 photosystem A complex located in a photosynthetic membrane that consists of a photoreaction center associated with accessory pigments and electron carriers. Examples of this component are found in Arabidopsis thaliana and in photosynthetic bacterial and archaeal species. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01006503001 42418385 42420545 GO:0009767 photosynthetic electron transport chain A process, occurring as part of photosynthesis, whereby light provides the energy for a series of electron carriers to operate together to transfer electrons and generate a transmembrane electrochemical gradient. IEA GO:0009523 photosystem II A photosystem that contains a pheophytin-quinone reaction center with associated accessory pigments and electron carriers. In cyanobacteria and chloroplasts, in the presence of light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone, whereas other photosynthetic bacteria carry out anoxygenic photosynthesis and oxidize other compounds to re-reduce the photoreaction center. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01006503001 42418385 42420545 GO:0009767 photosynthetic electron transport chain A process, occurring as part of photosynthesis, whereby light provides the energy for a series of electron carriers to operate together to transfer electrons and generate a transmembrane electrochemical gradient. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01006503001 42418385 42420545 GO:0009767 photosynthetic electron transport chain A process, occurring as part of photosynthesis, whereby light provides the energy for a series of electron carriers to operate together to transfer electrons and generate a transmembrane electrochemical gradient. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01006503001 42418385 42420545 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009521 photosystem A complex located in a photosynthetic membrane that consists of a photoreaction center associated with accessory pigments and electron carriers. Examples of this component are found in Arabidopsis thaliana and in photosynthetic bacterial and archaeal species. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01006503001 42418385 42420545 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009523 photosystem II A photosystem that contains a pheophytin-quinone reaction center with associated accessory pigments and electron carriers. In cyanobacteria and chloroplasts, in the presence of light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone, whereas other photosynthetic bacteria carry out anoxygenic photosynthesis and oxidize other compounds to re-reduce the photoreaction center. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01006503001 42418385 42420545 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01006503001 42418385 42420545 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01006503001 42418385 42420545 GO:0019684 photosynthesis, light reaction The light reactions of photosynthesis, which take place in photosystems II and I. Light energy is harvested and used to power the transfer of electrons among a series of electron donors and acceptors. The final electron acceptor is NADP+, which is reduced to NADPH. NADPH generated from light reactions is used in sugar synthesis in dark reactions. Light reactions also generate a proton motive force across the thylakoid membrane, and the proton gradient is used to synthesize ATP. There are two chemical reactions involved in the light reactions: water oxidation in photosystem II, and NADP reduction in photosystem I. IEA GO:0009521 photosystem A complex located in a photosynthetic membrane that consists of a photoreaction center associated with accessory pigments and electron carriers. Examples of this component are found in Arabidopsis thaliana and in photosynthetic bacterial and archaeal species. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01006503001 42418385 42420545 GO:0019684 photosynthesis, light reaction The light reactions of photosynthesis, which take place in photosystems II and I. Light energy is harvested and used to power the transfer of electrons among a series of electron donors and acceptors. The final electron acceptor is NADP+, which is reduced to NADPH. NADPH generated from light reactions is used in sugar synthesis in dark reactions. Light reactions also generate a proton motive force across the thylakoid membrane, and the proton gradient is used to synthesize ATP. There are two chemical reactions involved in the light reactions: water oxidation in photosystem II, and NADP reduction in photosystem I. IEA GO:0009523 photosystem II A photosystem that contains a pheophytin-quinone reaction center with associated accessory pigments and electron carriers. In cyanobacteria and chloroplasts, in the presence of light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone, whereas other photosynthetic bacteria carry out anoxygenic photosynthesis and oxidize other compounds to re-reduce the photoreaction center. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01006503001 42418385 42420545 GO:0019684 photosynthesis, light reaction The light reactions of photosynthesis, which take place in photosystems II and I. Light energy is harvested and used to power the transfer of electrons among a series of electron donors and acceptors. The final electron acceptor is NADP+, which is reduced to NADPH. NADPH generated from light reactions is used in sugar synthesis in dark reactions. Light reactions also generate a proton motive force across the thylakoid membrane, and the proton gradient is used to synthesize ATP. There are two chemical reactions involved in the light reactions: water oxidation in photosystem II, and NADP reduction in photosystem I. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01006503001 42418385 42420545 GO:0019684 photosynthesis, light reaction The light reactions of photosynthesis, which take place in photosystems II and I. Light energy is harvested and used to power the transfer of electrons among a series of electron donors and acceptors. The final electron acceptor is NADP+, which is reduced to NADPH. NADPH generated from light reactions is used in sugar synthesis in dark reactions. Light reactions also generate a proton motive force across the thylakoid membrane, and the proton gradient is used to synthesize ATP. There are two chemical reactions involved in the light reactions: water oxidation in photosystem II, and NADP reduction in photosystem I. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01016297001 5400176 5405263 GSVIVG01032521001 28051255 28057707 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01032521001 28051255 28057707 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032521001 28051255 28057707 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01038676001 21062995 21065000 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA. IEA GO:0004540 ribonuclease activity GSVIVG01028161001 4307488 4308536 GSVIVG01015089001 949385 955323 GSVIVG01013654001 2000855 2003274 GSVIVG01015251001 2118789 2123263 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01015251001 2118789 2123263 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01021161001 2036760 2040965 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01021161001 2036760 2040965 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01021161001 2036760 2040965 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01021161001 2036760 2040965 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01021161001 2036760 2040965 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01021161001 2036760 2040965 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01008582001 734895 740741 GSVIVG01032807001 603331 605773 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01032807001 603331 605773 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01029716001 13582094 13582684 GSVIVG01036426001 5024019 5028275 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01036426001 5024019 5028275 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01027829001 8274025 8280970 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01021231001 2790462 2792177 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01021231001 2790462 2792177 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01021231001 2790462 2792177 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01021231001 2790462 2792177 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01021231001 2790462 2792177 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01021231001 2790462 2792177 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01021231001 2790462 2792177 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021231001 2790462 2792177 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025411001 996654 998179 GSVIVG01026170001 13329257 13370578 GSVIVG01004381001 38321242 38322252 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01004381001 38321242 38322252 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01004381001 38321242 38322252 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA GO:0008061 chitin binding GSVIVG01004381001 38321242 38322252 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA GO:0008061 chitin binding GSVIVG01009021001 4338564 4341668 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01009021001 4338564 4341668 Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium. IEA GO:0005544 calcium-dependent phospholipid binding GSVIVG01035584001 2501024 2518571 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01035584001 2501024 2518571 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01035584001 2501024 2518571 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030243001 9963894 9964942 GSVIVG01026191001 13742539 13761953 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01026191001 13742539 13761953 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01026191001 13742539 13761953 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01026191001 13742539 13761953 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01026191001 13742539 13761953 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021896001 5922201 5949542 GSVIVG01006026001 23283986 23286392 GSVIVG01029273001 17725371 17728584 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013381001 821288 826998 GSVIVG01022931001 17879196 17883578 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01022931001 17879196 17883578 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01022931001 17879196 17883578 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022931001 17879196 17883578 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007372001 31572529 31573245 GSVIVG01032803001 614964 617560 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01032803001 614964 617560 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01006905001 29020941 29022579 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01006905001 29020941 29022579 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032670001 1641324 1645980 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01032670001 1641324 1645980 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01032670001 1641324 1645980 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01032670001 1641324 1645980 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032670001 1641324 1645980 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026773001 6827033 6833624 GSVIVG01000002001 2600404 2607034 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01000002001 2600404 2607034 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01000002001 2600404 2607034 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01000002001 2600404 2607034 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01000002001 2600404 2607034 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01000002001 2600404 2607034 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01000002001 2600404 2607034 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01000002001 2600404 2607034 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01000002001 2600404 2607034 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01000002001 2600404 2607034 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01000002001 2600404 2607034 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01000002001 2600404 2607034 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01000002001 2600404 2607034 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01000002001 2600404 2607034 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01000002001 2600404 2607034 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01000002001 2600404 2607034 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01008071001 6068418 6071094 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01013610001 1354701 1360935 GSVIVG01025349001 1640235 1647145 Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01008419001 2282059 2286605 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01008419001 2282059 2286605 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01008419001 2282059 2286605 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01008419001 2282059 2286605 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01008419001 2282059 2286605 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01008419001 2282059 2286605 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01008419001 2282059 2286605 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01008419001 2282059 2286605 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01008419001 2282059 2286605 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01008419001 2282059 2286605 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01008419001 2282059 2286605 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01008419001 2282059 2286605 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01008419001 2282059 2286605 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01008419001 2282059 2286605 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01008419001 2282059 2286605 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01018481001 14522282 14523816 GSVIVG01027647001 14680998 14682988 GSVIVG01022262001 17985625 17996066 GSVIVG01016004001 17211284 17217566 GSVIVG01013623001 1814274 1826984 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01006950001 29251070 29262168 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01021086001 1335630 1338022 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01021086001 1335630 1338022 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008101001 5792561 5795158 GSVIVG01023248001 20595791 20611182 GSVIVG01011272001 10306616 10320274 GO:0016226 iron-sulfur cluster assembly The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01011272001 10306616 10320274 GO:0016226 iron-sulfur cluster assembly The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01032921001 24150263 24158205 GO:0006364 rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01032921001 24150263 24158205 GO:0042254 ribosome biogenesis The process of the formation of the constituents of the ribosome subunits, their assembly, and their transport to the sites of protein synthesis. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01027134001 17557053 17560577 GSVIVG01016243001 6006136 6007252 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. IEA GO:0008080 N-acetyltransferase activity GSVIVG01016243001 6006136 6007252 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. IEA GO:0008080 N-acetyltransferase activity GSVIVG01016243001 6006136 6007252 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01016243001 6006136 6007252 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01030449001 5644843 5645490 GSVIVG01024474001 3083403 3084711 GSVIVG01037022001 8820035 8820694 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01037022001 8820035 8820694 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01029126001 19328286 19331579 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01029126001 19328286 19331579 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01029126001 19328286 19331579 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01009553001 9336602 9346057 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035607001 2657033 2657524 GSVIVG01016719001 616389 620445 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035323001 466492 470163 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01035323001 466492 470163 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01035323001 466492 470163 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01035323001 466492 470163 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01035323001 466492 470163 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019503001 1168949 1169486 GSVIVG01015044001 690713 699780 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01032675001 1602971 1606839 GO:0006801 superoxide metabolic process The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species. IEA Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + H2O2. IEA GO:0004784 superoxide dismutase activity GSVIVG01032675001 1602971 1606839 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + H2O2. IEA GO:0004784 superoxide dismutase activity GSVIVG01032675001 1602971 1606839 GO:0006801 superoxide metabolic process The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01032675001 1602971 1606839 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01006882001 28877727 28878070 GSVIVG01009032001 4425433 4426609 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01033354001 21260307 21260735 GSVIVG01008093001 5834789 5839316 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01020514001 18056453 18061495 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01020514001 18056453 18061495 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01020514001 18056453 18061495 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01020514001 18056453 18061495 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020514001 18056453 18061495 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022054001 3621623 3647029 GSVIVG01034909001 19031 27806 GSVIVG01007680001 10498682 10509520 GSVIVG01021579001 7394262 7397635 GSVIVG01037218001 27859844 27862659 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031142001 1777673 1784119 GO:0006413 translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. IEA GO:0003743 translation initiation factor activity GSVIVG01031142001 1777673 1784119 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. IEA GO:0003743 translation initiation factor activity GSVIVG01031142001 1777673 1784119 GO:0006413 translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01031142001 1777673 1784119 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01031142001 1777673 1784119 GO:0006413 translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01031142001 1777673 1784119 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01035314001 397122 399004 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01001034001 6703457 6706115 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01017730001 2987201 2989765 GO:0008299 isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. IEA GSVIVG01000669001 20591718 20648222 GSVIVG01037699001 7059267 7061190 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01025236001 2863548 2891273 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: ATP + NAD+ = ADP + NADP+. IEA GO:0003951 NAD+ kinase activity GSVIVG01011703001 4953886 4958333 GSVIVG01031794001 4427053 4429871 Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01031794001 4427053 4429871 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01032825001 463526 468545 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032825001 463526 468545 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027185001 17179656 17186400 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01015541001 4690123 4694572 GO:0032313 regulation of Rab GTPase activity Any process that modulates the activity of a GTPase of the Rab family. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Increases the rate of GTP hydrolysis by a GTPase of the Rab family. IEA GO:0005097 Rab GTPase activator activity GSVIVG01000168001 15821751 15822734 GSVIVG01017707001 2813784 2814029 GSVIVG01007910001 7659526 7662326 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007910001 7659526 7662326 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007910001 7659526 7662326 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01007910001 7659526 7662326 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01007910001 7659526 7662326 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01007910001 7659526 7662326 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01007910001 7659526 7662326 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01007910001 7659526 7662326 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01007910001 7659526 7662326 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01007910001 7659526 7662326 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01007910001 7659526 7662326 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01007910001 7659526 7662326 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01009496001 8856216 8859960 GSVIVG01004097001 14772439 14773977 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01004097001 14772439 14773977 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01004097001 14772439 14773977 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01004097001 14772439 14773977 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01004097001 14772439 14773977 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01004097001 14772439 14773977 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01004097001 14772439 14773977 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01004097001 14772439 14773977 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01004097001 14772439 14773977 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01004097001 14772439 14773977 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01018934001 18547145 18550545 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019325001 1102826 1105689 GSVIVG01021443001 5400155 5403578 GSVIVG01009769001 11143665 11148117 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01014028001 9280395 9291389 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035094001 1430324 1433336 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01004904001 4681634 4682139 GSVIVG01029274001 17705421 17709954 GSVIVG01028320001 6140557 6142750 GSVIVG01018897001 18825883 18839490 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01020465001 19011212 19012009 GSVIVG01005056001 17749840 17750024 GSVIVG01006947001 29220489 29221592 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01010714001 12418835 12419601 GSVIVG01030444001 5592369 5609564 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01030444001 5592369 5609564 GO:0008037 cell recognition The process by which a cell in a multicellular organism interprets its surroundings. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01030444001 5592369 5609564 GO:0019058 viral infectious cycle A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01030444001 5592369 5609564 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01030444001 5592369 5609564 GO:0008037 cell recognition The process by which a cell in a multicellular organism interprets its surroundings. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01030444001 5592369 5609564 GO:0019058 viral infectious cycle A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01030444001 5592369 5609564 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01030444001 5592369 5609564 GO:0008037 cell recognition The process by which a cell in a multicellular organism interprets its surroundings. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01030444001 5592369 5609564 GO:0019058 viral infectious cycle A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01030444001 5592369 5609564 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030444001 5592369 5609564 GO:0008037 cell recognition The process by which a cell in a multicellular organism interprets its surroundings. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030444001 5592369 5609564 GO:0019058 viral infectious cycle A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030444001 5592369 5609564 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030444001 5592369 5609564 GO:0008037 cell recognition The process by which a cell in a multicellular organism interprets its surroundings. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030444001 5592369 5609564 GO:0019058 viral infectious cycle A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030444001 5592369 5609564 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01030444001 5592369 5609564 GO:0008037 cell recognition The process by which a cell in a multicellular organism interprets its surroundings. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01030444001 5592369 5609564 GO:0019058 viral infectious cycle A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01013566001 20967342 21013412 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01013566001 20967342 21013412 GO:0009098 leucine biosynthetic process The chemical reactions and pathways resulting in the formation of leucine, 2-amino-4-methylpentanoic acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01013566001 20967342 21013412 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: acetyl-CoA + 3-methyl-2-oxobutanoate + H2O = (2S)-2-isopropylmalate + CoA. IEA GO:0003852 2-isopropylmalate synthase activity GSVIVG01013566001 20967342 21013412 GO:0009098 leucine biosynthetic process The chemical reactions and pathways resulting in the formation of leucine, 2-amino-4-methylpentanoic acid. IEA Catalysis of the reaction: acetyl-CoA + 3-methyl-2-oxobutanoate + H2O = (2S)-2-isopropylmalate + CoA. IEA GO:0003852 2-isopropylmalate synthase activity GSVIVG01022998001 17136465 17148823 GSVIVG01037932001 11094872 11099296 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01024519001 9333645 9367047 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01024519001 9333645 9367047 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01024519001 9333645 9367047 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01024519001 9333645 9367047 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01024519001 9333645 9367047 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01024519001 9333645 9367047 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01024519001 9333645 9367047 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01024519001 9333645 9367047 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01024519001 9333645 9367047 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024519001 9333645 9367047 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024519001 9333645 9367047 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024519001 9333645 9367047 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024519001 9333645 9367047 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01024519001 9333645 9367047 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01024519001 9333645 9367047 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01024519001 9333645 9367047 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01024519001 9333645 9367047 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024519001 9333645 9367047 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024519001 9333645 9367047 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024519001 9333645 9367047 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024519001 9333645 9367047 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01024519001 9333645 9367047 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01024519001 9333645 9367047 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01024519001 9333645 9367047 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01024519001 9333645 9367047 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01024519001 9333645 9367047 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01024519001 9333645 9367047 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01024519001 9333645 9367047 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01024519001 9333645 9367047 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwinding of the DNA helix in the direction 3' to 5'. IEA GO:0043140 ATP-dependent 3'-5' DNA helicase activity GSVIVG01024519001 9333645 9367047 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwinding of the DNA helix in the direction 3' to 5'. IEA GO:0043140 ATP-dependent 3'-5' DNA helicase activity GSVIVG01024519001 9333645 9367047 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwinding of the DNA helix in the direction 3' to 5'. IEA GO:0043140 ATP-dependent 3'-5' DNA helicase activity GSVIVG01024519001 9333645 9367047 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwinding of the DNA helix in the direction 3' to 5'. IEA GO:0043140 ATP-dependent 3'-5' DNA helicase activity GSVIVG01004646001 39337842 39338166 GSVIVG01034306001 14422854 14436583 GSVIVG01011709001 4904273 4911526 GSVIVG01016728001 692068 695053 GO:0006183 GTP biosynthetic process The chemical reactions and pathways resulting in the formation of GTP, guanosine triphosphate. IEA Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. IEA GO:0004550 nucleoside diphosphate kinase activity GSVIVG01016728001 692068 695053 GO:0006228 UTP biosynthetic process The chemical reactions and pathways resulting in the formation of UTP, uridine (5'-)triphosphate. IEA Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. IEA GO:0004550 nucleoside diphosphate kinase activity GSVIVG01016728001 692068 695053 GO:0006241 CTP biosynthetic process The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate. IEA Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. IEA GO:0004550 nucleoside diphosphate kinase activity GSVIVG01016728001 692068 695053 GO:0006183 GTP biosynthetic process The chemical reactions and pathways resulting in the formation of GTP, guanosine triphosphate. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016728001 692068 695053 GO:0006228 UTP biosynthetic process The chemical reactions and pathways resulting in the formation of UTP, uridine (5'-)triphosphate. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016728001 692068 695053 GO:0006241 CTP biosynthetic process The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030506001 6283765 6295635 GSVIVG01032139001 22270442 22271314 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032139001 22270442 22271314 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018441001 15079574 15080790 GSVIVG01034077001 15350148 15358033 GSVIVG01028727001 19365747 19368456 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01028727001 19365747 19368456 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01028727001 19365747 19368456 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01028727001 19365747 19368456 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01028727001 19365747 19368456 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028599001 10438570 10441028 GO:0009690 cytokinin metabolic process The chemical reactions and pathways involving cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028599001 10438570 10441028 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028599001 10438570 10441028 GO:0009690 cytokinin metabolic process The chemical reactions and pathways involving cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01028599001 10438570 10441028 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01028599001 10438570 10441028 GO:0009690 cytokinin metabolic process The chemical reactions and pathways involving cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators. IEA Catalysis of the reaction: N6-dimethylallyladenine + acceptor + H2O = adenine + 3-methylbut-2-enal + reduced electron acceptor. IEA GO:0019139 cytokinin dehydrogenase activity GSVIVG01028599001 10438570 10441028 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: N6-dimethylallyladenine + acceptor + H2O = adenine + 3-methylbut-2-enal + reduced electron acceptor. IEA GO:0019139 cytokinin dehydrogenase activity GSVIVG01028599001 10438570 10441028 GO:0009690 cytokinin metabolic process The chemical reactions and pathways involving cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01028599001 10438570 10441028 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01033681001 18727578 18735964 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01033681001 18727578 18735964 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01033681001 18727578 18735964 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01033681001 18727578 18735964 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01033681001 18727578 18735964 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01033681001 18727578 18735964 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033681001 18727578 18735964 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033681001 18727578 18735964 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033681001 18727578 18735964 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033681001 18727578 18735964 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033681001 18727578 18735964 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01033681001 18727578 18735964 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01033681001 18727578 18735964 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01033681001 18727578 18735964 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01033681001 18727578 18735964 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01000809001 365697 379381 GSVIVG01026761001 6465643 6478681 GSVIVG01021151001 1865827 1868875 GO:0019478 D-amino acid catabolic process The chemical reactions and pathways resulting in the breakdown of D-amino acids, the D-enantiomers of amino acids. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01035330001 531361 536648 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035330001 531361 536648 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035330001 531361 536648 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01035330001 531361 536648 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01035330001 531361 536648 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA A sigma factor is the promoter specificity subunit of eubacterial-type multisubunit RNA polymerases, those whose core subunit composition is often described as alpha(2)-beta-beta-prime. (This type of multisubunit RNA polymerase complex is known to be found in eubacteria and plant plastids). Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, this binds specifically to promoter sequences, with the sigma factor making sequence specific contacts with the promoter elements. The sigma subunit is released from the elongating form of the polymerase and is thus free to act catalytically for multiple RNA polymerase core enzymes. IEA GO:0016987 sigma factor activity GSVIVG01035330001 531361 536648 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA A sigma factor is the promoter specificity subunit of eubacterial-type multisubunit RNA polymerases, those whose core subunit composition is often described as alpha(2)-beta-beta-prime. (This type of multisubunit RNA polymerase complex is known to be found in eubacteria and plant plastids). Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, this binds specifically to promoter sequences, with the sigma factor making sequence specific contacts with the promoter elements. The sigma subunit is released from the elongating form of the polymerase and is thus free to act catalytically for multiple RNA polymerase core enzymes. IEA GO:0016987 sigma factor activity GSVIVG01037694001 6960133 6964793 GSVIVG01000587001 6782564 6810457 GO:0030833 regulation of actin filament polymerization Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament. IEA GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01000587001 6782564 6810457 GO:0030833 regulation of actin filament polymerization Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament. IEA GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000587001 6782564 6810457 GO:0030833 regulation of actin filament polymerization Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament. IEA GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036255001 7959858 7970729 GSVIVG01038765001 680639 682121 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01038765001 680639 682121 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01038765001 680639 682121 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01038765001 680639 682121 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022706001 15341994 15343545 GSVIVG01034731001 8552922 8555637 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01034731001 8552922 8555637 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01020137001 9932805 9946212 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020137001 9932805 9946212 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01020137001 9932805 9946212 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01020137001 9932805 9946212 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020137001 9932805 9946212 Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01020137001 9932805 9946212 Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. IEA GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GSVIVG01020137001 9932805 9946212 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01011311001 8288511 8297475 GSVIVG01016288001 5521918 5529178 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the reaction: 5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. IEA GO:0004107 chorismate synthase activity GSVIVG01016288001 5521918 5529178 GO:0009073 aromatic amino acid family biosynthetic process The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). IEA Catalysis of the reaction: 5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. IEA GO:0004107 chorismate synthase activity GSVIVG01016288001 5521918 5529178 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01016288001 5521918 5529178 GO:0009073 aromatic amino acid family biosynthetic process The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01016703001 477083 478177 GSVIVG01000845001 2861169 2865232 GSVIVG01008959001 3852041 3861196 Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01035796001 4431413 4432859 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01035796001 4431413 4432859 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021707001 9832350 9836904 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01021707001 9832350 9836904 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01021707001 9832350 9836904 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01021707001 9832350 9836904 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01021707001 9832350 9836904 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01021707001 9832350 9836904 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01021707001 9832350 9836904 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01021707001 9832350 9836904 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01021707001 9832350 9836904 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01021707001 9832350 9836904 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01021707001 9832350 9836904 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01021707001 9832350 9836904 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01021707001 9832350 9836904 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01021707001 9832350 9836904 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01021707001 9832350 9836904 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01021707001 9832350 9836904 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01021707001 9832350 9836904 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01021707001 9832350 9836904 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01021707001 9832350 9836904 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01021707001 9832350 9836904 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01021707001 9832350 9836904 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01021707001 9832350 9836904 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01021707001 9832350 9836904 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01021707001 9832350 9836904 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01021707001 9832350 9836904 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01021707001 9832350 9836904 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01021707001 9832350 9836904 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01011416001 29511993 29512103 GSVIVG01036519001 23001053 23005055 GSVIVG01000635001 20224126 20250639 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000635001 20224126 20250639 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000635001 20224126 20250639 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000635001 20224126 20250639 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026268001 15190286 15195417 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01020470001 18966010 18966189 GSVIVG01000287001 2295643 2296568 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01000287001 2295643 2296568 Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium. IEA GO:0005544 calcium-dependent phospholipid binding GSVIVG01003133001 7527696 7537415 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). IEA GO:0003755 peptidyl-prolyl cis-trans isomerase activity GSVIVG01007933001 7414904 7417081 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01007933001 7414904 7417081 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01007933001 7414904 7417081 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01007933001 7414904 7417081 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01007933001 7414904 7417081 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01007933001 7414904 7417081 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01007933001 7414904 7417081 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01007933001 7414904 7417081 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01010068001 14669981 14678135 GO:0006221 pyrimidine nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010068001 14669981 14678135 GO:0006541 glutamine metabolic process The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010068001 14669981 14678135 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010068001 14669981 14678135 GO:0006221 pyrimidine nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. IEA Catalysis of the reaction: ATP + UTP + NH3 = ADP + phosphate + CTP. IEA GO:0003883 CTP synthase activity GSVIVG01010068001 14669981 14678135 GO:0006541 glutamine metabolic process The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid. IEA Catalysis of the reaction: ATP + UTP + NH3 = ADP + phosphate + CTP. IEA GO:0003883 CTP synthase activity GSVIVG01010068001 14669981 14678135 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: ATP + UTP + NH3 = ADP + phosphate + CTP. IEA GO:0003883 CTP synthase activity GSVIVG01010068001 14669981 14678135 GO:0006221 pyrimidine nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01010068001 14669981 14678135 GO:0006541 glutamine metabolic process The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01010068001 14669981 14678135 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016259001 5829784 5834381 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016259001 5829784 5834381 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01036199001 9139528 9139749 GSVIVG01021660001 8847201 8857764 GSVIVG01009627001 10026699 10031929 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01009627001 10026699 10031929 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008104001 5760558 5770494 GSVIVG01009487001 8774625 8779118 GSVIVG01034166001 14715871 14719563 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01005643001 20814296 20815128 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01021854001 6462432 6466040 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01021854001 6462432 6466040 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01021854001 6462432 6466040 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01021854001 6462432 6466040 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019655001 2249075 2251461 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019655001 2249075 2251461 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019655001 2249075 2251461 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019655001 2249075 2251461 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01019655001 2249075 2251461 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01019655001 2249075 2251461 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01019655001 2249075 2251461 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01019655001 2249075 2251461 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01019655001 2249075 2251461 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01019655001 2249075 2251461 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01019655001 2249075 2251461 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01019655001 2249075 2251461 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01033999001 16006254 16008777 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01007562001 12001518 12004913 GSVIVG01017954001 5055644 5059039 GO:0009308 amine metabolic process The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01017954001 5055644 5059039 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01017954001 5055644 5059039 GO:0009308 amine metabolic process The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. IEA Catalysis of the reaction: R-CH2-NH2 + H2O + O2 = R-CHO + NH3 + H2O2. IEA GO:0008131 amine oxidase activity GSVIVG01017954001 5055644 5059039 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: R-CH2-NH2 + H2O + O2 = R-CHO + NH3 + H2O2. IEA GO:0008131 amine oxidase activity GSVIVG01017954001 5055644 5059039 GO:0009308 amine metabolic process The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. IEA Interacting selectively and non-covalently with a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds. IEA GO:0048038 quinone binding GSVIVG01017954001 5055644 5059039 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds. IEA GO:0048038 quinone binding GSVIVG01021400001 4924464 4933870 GSVIVG01030390001 5162457 5169866 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01030390001 5162457 5169866 GO:0051090 regulation of transcription factor activity Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01030390001 5162457 5169866 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Functions to initiate or regulate RNA polymerase II transcription. IEA GO:0003702 RNA polymerase II transcription factor activity GSVIVG01030390001 5162457 5169866 GO:0051090 regulation of transcription factor activity Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Functions to initiate or regulate RNA polymerase II transcription. IEA GO:0003702 RNA polymerase II transcription factor activity GSVIVG01030390001 5162457 5169866 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01030390001 5162457 5169866 GO:0051090 regulation of transcription factor activity Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01030390001 5162457 5169866 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA IEA GO:0016986 transcription initiation factor activity GSVIVG01030390001 5162457 5169866 GO:0051090 regulation of transcription factor activity Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA IEA GO:0016986 transcription initiation factor activity GSVIVG01023247001 20625246 20627584 GSVIVG01001346001 23812858 23813769 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001346001 23812858 23813769 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01030648001 7469483 7470668 GSVIVG01016831001 1757762 1758145 GSVIVG01022601001 5783366 5792127 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01022601001 5783366 5792127 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016602 CCAAT-binding factor complex A heteromeric transcription factor complex that binds to the CCAAT-box upstream of promoters; in Saccharomyces it activates the transcription of genes in response to growth in a nonfermentable carbon source; consists of four known subunits: HAP2, HAP3, HAP4 and HAP5. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01022601001 5783366 5792127 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01022601001 5783366 5792127 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016602 CCAAT-binding factor complex A heteromeric transcription factor complex that binds to the CCAAT-box upstream of promoters; in Saccharomyces it activates the transcription of genes in response to growth in a nonfermentable carbon source; consists of four known subunits: HAP2, HAP3, HAP4 and HAP5. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01010170001 16739674 16740975 GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. IEA Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+. IEA GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity GSVIVG01010170001 16739674 16740975 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+. IEA GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity GSVIVG01010170001 16739674 16740975 GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01010170001 16739674 16740975 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01010170001 16739674 16740975 GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01010170001 16739674 16740975 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01010170001 16739674 16740975 GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01010170001 16739674 16740975 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01035799001 4457279 4468972 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035799001 4457279 4468972 GO:0016114 terpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035799001 4457279 4468972 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. IEA GO:0008661 1-deoxy-D-xylulose-5-phosphate synthase activity GSVIVG01035799001 4457279 4468972 GO:0016114 terpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure. IEA Catalysis of the reaction: pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. IEA GO:0008661 1-deoxy-D-xylulose-5-phosphate synthase activity GSVIVG01035554001 2250744 2253524 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01037192001 28144008 28159521 GO:0006413 translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01037192001 28144008 28159521 GO:0006413 translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. IEA Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. IEA GO:0003743 translation initiation factor activity GSVIVG01026930001 19322715 19324825 Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. IEA GO:0005089 Rho guanyl-nucleotide exchange factor activity GSVIVG01004778001 16036957 16042128 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01016478001 3523584 3533997 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020387001 20238195 20240748 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01033911001 16801152 16801955 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033911001 16801152 16801955 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033911001 16801152 16801955 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033911001 16801152 16801955 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033911001 16801152 16801955 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033911001 16801152 16801955 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033911001 16801152 16801955 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01033911001 16801152 16801955 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01033911001 16801152 16801955 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01033911001 16801152 16801955 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033911001 16801152 16801955 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033911001 16801152 16801955 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01017350001 7074049 7079141 GSVIVG01022835001 18936503 18951047 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031096001 2402809 2403275 GSVIVG01016843001 1871334 1873954 GSVIVG01032481001 27782988 27784318 GSVIVG01013469001 176322 177599 GSVIVG01035938001 6153541 6159242 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01021880001 6077849 6083830 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021880001 6077849 6083830 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021880001 6077849 6083830 GO:0006535 cysteine biosynthetic process from serine The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021880001 6077849 6083830 GO:0006535 cysteine biosynthetic process from serine The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021880001 6077849 6083830 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021880001 6077849 6083830 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021880001 6077849 6083830 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: O3-acetyl-L-serine + H2S = L-cysteine + acetate. IEA GO:0004124 cysteine synthase activity GSVIVG01021880001 6077849 6083830 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: O3-acetyl-L-serine + H2S = L-cysteine + acetate. IEA GO:0004124 cysteine synthase activity GSVIVG01021880001 6077849 6083830 GO:0006535 cysteine biosynthetic process from serine The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: O3-acetyl-L-serine + H2S = L-cysteine + acetate. IEA GO:0004124 cysteine synthase activity GSVIVG01021880001 6077849 6083830 GO:0006535 cysteine biosynthetic process from serine The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: O3-acetyl-L-serine + H2S = L-cysteine + acetate. IEA GO:0004124 cysteine synthase activity GSVIVG01021880001 6077849 6083830 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: O3-acetyl-L-serine + H2S = L-cysteine + acetate. IEA GO:0004124 cysteine synthase activity GSVIVG01021880001 6077849 6083830 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: O3-acetyl-L-serine + H2S = L-cysteine + acetate. IEA GO:0004124 cysteine synthase activity GSVIVG01021880001 6077849 6083830 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01021880001 6077849 6083830 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01021880001 6077849 6083830 GO:0006535 cysteine biosynthetic process from serine The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01021880001 6077849 6083830 GO:0006535 cysteine biosynthetic process from serine The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01021880001 6077849 6083830 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01021880001 6077849 6083830 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01021880001 6077849 6083830 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01021880001 6077849 6083830 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01021880001 6077849 6083830 GO:0006535 cysteine biosynthetic process from serine The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01021880001 6077849 6083830 GO:0006535 cysteine biosynthetic process from serine The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01021880001 6077849 6083830 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01021880001 6077849 6083830 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01027634001 14815231 14816827 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01011954001 2677376 2685001 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01014103001 434143 434694 GSVIVG01015660001 15151189 15174582 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01015660001 15151189 15174582 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01015660001 15151189 15174582 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01015660001 15151189 15174582 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01015660001 15151189 15174582 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01027118001 17677390 17689653 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01027118001 17677390 17689653 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01011268001 10281432 10288760 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01011268001 10281432 10288760 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01011268001 10281432 10288760 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01011268001 10281432 10288760 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01011268001 10281432 10288760 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01011268001 10281432 10288760 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01011268001 10281432 10288760 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01011268001 10281432 10288760 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01011268001 10281432 10288760 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01011268001 10281432 10288760 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01011268001 10281432 10288760 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01011268001 10281432 10288760 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01011268001 10281432 10288760 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01011268001 10281432 10288760 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01011268001 10281432 10288760 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01011268001 10281432 10288760 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01017819001 3710369 3717780 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01017819001 3710369 3717780 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01017819001 3710369 3717780 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01017819001 3710369 3717780 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017819001 3710369 3717780 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014589001 5400650 5404859 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01036764001 22835275 22848066 GSVIVG01035561001 2315532 2324965 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035561001 2315532 2324965 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035561001 2315532 2324965 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035561001 2315532 2324965 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035561001 2315532 2324965 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035561001 2315532 2324965 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035561001 2315532 2324965 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01035561001 2315532 2324965 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01035561001 2315532 2324965 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01035561001 2315532 2324965 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01035561001 2315532 2324965 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01035561001 2315532 2324965 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01004945001 16878273 16900069 GSVIVG01004724001 15530396 15540630 GO:0008654 phospholipid biosynthetic process The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester. IEA Catalysis of the reaction: phosphatidyl-L-serine = phosphatidylethanolamine + CO2. IEA GO:0004609 phosphatidylserine decarboxylase activity GSVIVG01031373001 19441285 19446238 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. IEA GO:0004725 protein tyrosine phosphatase activity GSVIVG01021115001 1594408 1596451 GSVIVG01024336001 1131075 1131560 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01024336001 1131075 1131560 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01024336001 1131075 1131560 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01024336001 1131075 1131560 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01010657001 15489329 15492190 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01017269001 6190468 6192820 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017269001 6190468 6192820 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017269001 6190468 6192820 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017269001 6190468 6192820 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008314001 3349146 3349561 GSVIVG01032798001 670695 673012 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032798001 670695 673012 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01006735001 27847352 27854047 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031436001 18604355 18607127 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0008236 serine-type peptidase activity GSVIVG01010502001 21155198 21161393 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01010502001 21155198 21161393 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01010502001 21155198 21161393 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01010502001 21155198 21161393 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01010502001 21155198 21161393 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01010502001 21155198 21161393 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01010502001 21155198 21161393 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01010502001 21155198 21161393 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01010502001 21155198 21161393 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01010502001 21155198 21161393 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01010502001 21155198 21161393 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01010502001 21155198 21161393 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01010502001 21155198 21161393 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01010502001 21155198 21161393 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01010502001 21155198 21161393 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01010502001 21155198 21161393 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01010502001 21155198 21161393 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01010502001 21155198 21161393 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01010502001 21155198 21161393 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01010502001 21155198 21161393 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01010502001 21155198 21161393 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01010502001 21155198 21161393 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01010502001 21155198 21161393 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01010502001 21155198 21161393 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01010502001 21155198 21161393 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01010502001 21155198 21161393 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010502001 21155198 21161393 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010502001 21155198 21161393 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010502001 21155198 21161393 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010502001 21155198 21161393 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010502001 21155198 21161393 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01010502001 21155198 21161393 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01010502001 21155198 21161393 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01010502001 21155198 21161393 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01010502001 21155198 21161393 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01010502001 21155198 21161393 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01010502001 21155198 21161393 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01010502001 21155198 21161393 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01010502001 21155198 21161393 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01010502001 21155198 21161393 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01021803001 7173849 7174286 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01021803001 7173849 7174286 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01026138001 12784476 12784727 GSVIVG01023591001 7736349 7741100 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01023591001 7736349 7741100 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01025726001 12617598 12619649 GSVIVG01003938001 8153444 8172675 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01003938001 8153444 8172675 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01031970001 5802834 5807050 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with damaged DNA. IEA GO:0003684 damaged DNA binding GSVIVG01031970001 5802834 5807050 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the degradation of double-stranded DNA. It acts progressively in a 3' to 5' direction, releasing 5'-phosphomononucleotides. IEA GO:0008853 exodeoxyribonuclease III activity GSVIVG01029557001 21578460 21625966 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01029557001 21578460 21625966 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01001183001 1033694 1034321 GSVIVG01023790001 3451340 3455891 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01023790001 3451340 3455891 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01023790001 3451340 3455891 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01023790001 3451340 3455891 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01023790001 3451340 3455891 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01023790001 3451340 3455891 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01005100001 18079105 18099336 GSVIVG01014646001 8197976 8202530 GSVIVG01003846001 12798237 12803264 GSVIVG01010937001 15393059 15395450 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01010937001 15393059 15395450 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01025828001 11433660 11436191 GSVIVG01009075001 4738323 4739988 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: cysteamine + O2 = hypotaurine. IEA GO:0047800 cysteamine dioxygenase activity GSVIVG01019999001 11793597 11793863 GSVIVG01014478001 4278165 4280582 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014478001 4278165 4280582 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014478001 4278165 4280582 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014478001 4278165 4280582 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036722001 23313349 23318736 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01005693001 21273463 21280888 GSVIVG01032795001 714500 715137 GSVIVG01008711001 1385951 1394801 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01018351001 10682329 10683562 GSVIVG01032114001 22543518 22546071 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01006484001 26428218 26433872 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01006484001 26428218 26433872 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01006484001 26428218 26433872 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01006484001 26428218 26433872 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01006484001 26428218 26433872 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01006484001 26428218 26433872 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01014564001 5198060 5199853 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) All non-F1 subunits of the mitochondrial hydrogen-transporting ATP synthase, including integral and peripheral mitochondrial inner membrane proteins. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01037123001 28905444 28917298 GSVIVG01036368001 4289405 4306081 Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01036368001 4289405 4306081 Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01000021001 2869540 2870678 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01037492001 12754661 12761944 GSVIVG01011982001 2427682 2428209 GSVIVG01023436001 11962521 11964001 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01003629001 527322 537491 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003629001 527322 537491 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01003629001 527322 537491 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01028366001 6657568 6686317 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01008756001 1727184 1728333 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01008756001 1727184 1728333 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01004032001 14343715 14349760 GSVIVG01017496001 9450669 9451058 GSVIVG01033926001 16671755 16672975 GSVIVG01012161001 949657 957893 GSVIVG01015187001 1642158 1646284 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01010095001 15296596 15296998 GSVIVG01032431001 27326620 27328806 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01010456001 20751549 20752616 GSVIVG01028450001 7785302 7786786 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01013255001 6184188 6195799 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01013255001 6184188 6195799 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01011458001 29784554 29785366 GSVIVG01022073001 16369432 16369536 GSVIVG01009537001 9147542 9149927 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA GSVIVG01009537001 9147542 9149927 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA GSVIVG01009537001 9147542 9149927 GO:0009405 pathogenesis The set of specific processes that generate the ability of an organism to cause disease in another. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA GSVIVG01012613001 31128 32814 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016651 oxidoreductase activity, acting on NADH or NADPH GSVIVG01012613001 31128 32814 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016651 oxidoreductase activity, acting on NADH or NADPH GSVIVG01012613001 31128 32814 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01012613001 31128 32814 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01012613001 31128 32814 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds. IEA GO:0048038 quinone binding GSVIVG01012613001 31128 32814 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds. IEA GO:0048038 quinone binding GSVIVG01012613001 31128 32814 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01012613001 31128 32814 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01023467001 11380307 11393515 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Functions to initiate or regulate RNA polymerase II transcription. IEA GO:0003702 RNA polymerase II transcription factor activity GSVIVG01023858001 2930058 2932804 GSVIVG01009238001 6526891 6532321 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01009238001 6526891 6532321 GO:0009734 auxin mediated signaling pathway The series of molecular signals generated in response to detection of auxin. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01009238001 6526891 6532321 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01009638001 10099744 10112854 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017448001 8704440 8708461 GO:0006571 tyrosine biosynthetic process The chemical reactions and pathways resulting in the formation of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01017448001 8704440 8708461 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01017448001 8704440 8708461 GO:0006571 tyrosine biosynthetic process The chemical reactions and pathways resulting in the formation of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid. IEA Catalysis of the reaction: prephenate + NADP+ = 4-hydroxyphenylpyruvate + CO2 + NADPH + H+. IEA GO:0004665 prephenate dehydrogenase (NADP+) activity GSVIVG01017448001 8704440 8708461 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: prephenate + NADP+ = 4-hydroxyphenylpyruvate + CO2 + NADPH + H+. IEA GO:0004665 prephenate dehydrogenase (NADP+) activity GSVIVG01017448001 8704440 8708461 GO:0006571 tyrosine biosynthetic process The chemical reactions and pathways resulting in the formation of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017448001 8704440 8708461 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01009710001 10670000 10675930 GSVIVG01016124001 19497426 19498322 GSVIVG01023845001 3030639 3032099 GSVIVG01007606001 11329650 11329799 GSVIVG01030269001 9651291 9653176 GSVIVG01024901001 6160246 6161260 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01021497001 6186589 6189566 GSVIVG01011198001 9338462 9345246 GSVIVG01024040001 1549919 1551865 GSVIVG01036278001 7599091 7600447 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01036278001 7599091 7600447 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01036278001 7599091 7600447 GO:0042742 defense response to bacterium Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01036278001 7599091 7600447 GO:0050832 defense response to fungus Reactions triggered in response to the presence of a fungus that act to protect the cell or organism. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01038264001 24796799 24802680 GO:0009269 response to desiccation A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a desiccation stimulus, extreme dryness resulting from the prolonged deprivation of water. IEA GSVIVG01013644001 2067966 2095680 GSVIVG01029270001 17753187 17757395 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029270001 17753187 17757395 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029270001 17753187 17757395 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01029270001 17753187 17757395 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01029270001 17753187 17757395 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01029270001 17753187 17757395 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01029270001 17753187 17757395 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01029270001 17753187 17757395 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01028540001 9431080 9434223 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01000041001 2992353 2997171 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01000041001 2992353 2997171 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01000041001 2992353 2997171 GO:0006434 seryl-tRNA aminoacylation The process of coupling serine to seryl-tRNA, catalyzed by seryl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01000041001 2992353 2997171 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01000041001 2992353 2997171 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01000041001 2992353 2997171 GO:0006434 seryl-tRNA aminoacylation The process of coupling serine to seryl-tRNA, catalyzed by seryl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01000041001 2992353 2997171 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser). IEA GO:0004828 serine-tRNA ligase activity GSVIVG01000041001 2992353 2997171 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser). IEA GO:0004828 serine-tRNA ligase activity GSVIVG01000041001 2992353 2997171 GO:0006434 seryl-tRNA aminoacylation The process of coupling serine to seryl-tRNA, catalyzed by seryl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser). IEA GO:0004828 serine-tRNA ligase activity GSVIVG01000041001 2992353 2997171 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000041001 2992353 2997171 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000041001 2992353 2997171 GO:0006434 seryl-tRNA aminoacylation The process of coupling serine to seryl-tRNA, catalyzed by seryl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008933001 3562458 3563622 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01008933001 3562458 3563622 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01008933001 3562458 3563622 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01008933001 3562458 3563622 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01008933001 3562458 3563622 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01008933001 3562458 3563622 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01033095001 25675571 25679342 GSVIVG01005042001 17636347 17639822 GSVIVG01015401001 3289542 3294941 GO:0009269 response to desiccation A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a desiccation stimulus, extreme dryness resulting from the prolonged deprivation of water. IEA GSVIVG01002524001 35183642 35186324 GSVIVG01009906001 12299117 12301801 GSVIVG01017684001 2640364 2644421 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01017684001 2640364 2644421 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01017684001 2640364 2644421 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01017684001 2640364 2644421 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01017684001 2640364 2644421 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01017684001 2640364 2644421 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01017684001 2640364 2644421 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017684001 2640364 2644421 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017684001 2640364 2644421 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017684001 2640364 2644421 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01017684001 2640364 2644421 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01017684001 2640364 2644421 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01011761001 4423798 4425005 GSVIVG01005998001 24322716 24324584 GSVIVG01033414001 20884886 20888537 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033414001 20884886 20888537 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033414001 20884886 20888537 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033414001 20884886 20888537 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01014718001 8945634 8949046 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01014718001 8945634 8949046 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01029836001 301073 310664 GO:0006364 rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. IEA GO:0032040 small-subunit processome A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins. IEA GSVIVG01007386001 909898 910737 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01007386001 909898 910737 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01007386001 909898 910737 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01007386001 909898 910737 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01007386001 909898 910737 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01007386001 909898 910737 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01007386001 909898 910737 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01007386001 909898 910737 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01007386001 909898 910737 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01007386001 909898 910737 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01007386001 909898 910737 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01007386001 909898 910737 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01007386001 909898 910737 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007386001 909898 910737 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007386001 909898 910737 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007386001 909898 910737 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007386001 909898 910737 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007386001 909898 910737 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007386001 909898 910737 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01007386001 909898 910737 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01007386001 909898 910737 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01007386001 909898 910737 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01007386001 909898 910737 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01007386001 909898 910737 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01007386001 909898 910737 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01007386001 909898 910737 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01007386001 909898 910737 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01007386001 909898 910737 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01007386001 909898 910737 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01007386001 909898 910737 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01007386001 909898 910737 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01007386001 909898 910737 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01007386001 909898 910737 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01007386001 909898 910737 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01007386001 909898 910737 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01007386001 909898 910737 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01007386001 909898 910737 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01007386001 909898 910737 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01007386001 909898 910737 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01007386001 909898 910737 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01007386001 909898 910737 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01007386001 909898 910737 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01023197001 21236421 21238510 GSVIVG01012594001 4459773 4464714 GSVIVG01007869001 8158122 8165201 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01007869001 8158122 8165201 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01007869001 8158122 8165201 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01007869001 8158122 8165201 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01007869001 8158122 8165201 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01007869001 8158122 8165201 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01007869001 8158122 8165201 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01007869001 8158122 8165201 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01002833001 36876661 36878443 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01031731001 3889562 3890478 GSVIVG01002027001 32347376 32353512 GO:0007205 activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway The initiation of the activity of the inactive enzyme protein kinase C as the result of a series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol 3-phosphate. IEA GO:0004143 diacylglycerol kinase activity GSVIVG01018911001 18715799 18719071 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01000451001 8133181 8135185 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01023035001 16571477 16572434 GSVIVG01025879001 27560396 27577010 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025879001 27560396 27577010 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01025879001 27560396 27577010 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01025879001 27560396 27577010 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025879001 27560396 27577010 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01025879001 27560396 27577010 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01025879001 27560396 27577010 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01029768001 14428885 14434342 GSVIVG01027147001 17423831 17430685 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01027147001 17423831 17430685 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01027147001 17423831 17430685 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01027147001 17423831 17430685 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01014106001 468848 472363 GSVIVG01013284001 5669660 5669797 GSVIVG01031064001 21612988 21742019 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025544001 14149736 14165528 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01008069001 6081601 6089504 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008069001 6081601 6089504 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008069001 6081601 6089504 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008069001 6081601 6089504 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01008069001 6081601 6089504 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01008069001 6081601 6089504 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01008069001 6081601 6089504 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008069001 6081601 6089504 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008069001 6081601 6089504 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008069001 6081601 6089504 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01008069001 6081601 6089504 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01008069001 6081601 6089504 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01008069001 6081601 6089504 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008069001 6081601 6089504 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008069001 6081601 6089504 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01011682001 5138986 5144028 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01011682001 5138986 5144028 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01011682001 5138986 5144028 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01016131001 19536207 19551139 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide. IEA GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor GSVIVG01033907001 16821659 16832551 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033907001 16821659 16832551 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033907001 16821659 16832551 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008237 metallopeptidase activity GSVIVG01033907001 16821659 16832551 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008237 metallopeptidase activity GSVIVG01033907001 16821659 16832551 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01033907001 16821659 16832551 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01033907001 16821659 16832551 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01033907001 16821659 16832551 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01000427001 7824297 7855289 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01000427001 7824297 7855289 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01000427001 7824297 7855289 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01000427001 7824297 7855289 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008451001 1883950 1899856 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008451001 1883950 1899856 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01006157001 42227032 42228490 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01006157001 42227032 42228490 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028106001 3854118 3854906 GSVIVG01027221001 18009109 18010668 GSVIVG01024976001 5570830 5573899 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000097001 3515322 3516355 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with manganese (Mn) ions. IEA GO:0030145 manganese ion binding GSVIVG01000097001 3515322 3516355 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Functions in the storage of nutritious substrates. IEA GO:0045735 nutrient reservoir activity GSVIVG01000097001 3515322 3516355 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01011652001 5581263 5585379 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01011652001 5581263 5585379 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01011652001 5581263 5585379 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01011652001 5581263 5585379 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014807001 10028797 10030110 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with transfer RNA. IEA GO:0000049 tRNA binding GSVIVG01014807001 10028797 10030110 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe). IEA GO:0004826 phenylalanine-tRNA ligase activity GSVIVG01014807001 10028797 10030110 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015983001 16786307 16792874 GSVIVG01023207001 21102291 21105478 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023207001 21102291 21105478 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023207001 21102291 21105478 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023207001 21102291 21105478 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023207001 21102291 21105478 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023207001 21102291 21105478 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023207001 21102291 21105478 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01023207001 21102291 21105478 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01026243001 14720483 14722648 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01026243001 14720483 14722648 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01026243001 14720483 14722648 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01026243001 14720483 14722648 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01026243001 14720483 14722648 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01026243001 14720483 14722648 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01030487001 6103353 6111366 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01030487001 6103353 6111366 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030487001 6103353 6111366 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01030487001 6103353 6111366 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01015714001 16245391 16254121 GSVIVG01032859001 171572 173017 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027223001 17903631 17906550 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01027223001 17903631 17906550 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01014653001 8232992 8235393 GSVIVG01022060001 16284267 16290893 GO:0016311 dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. IEA Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. IEA GO:0004725 protein tyrosine phosphatase activity GSVIVG01022060001 16284267 16290893 GO:0016311 dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. IEA Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. IEA GO:0016791 phosphatase activity GSVIVG01035919001 5817197 5849576 GSVIVG01029124001 19351635 19352156 GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA GSVIVG01012130001 1187499 1191134 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GSVIVG01017792001 3504871 3516200 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion. IEA GO:0004806 triglyceride lipase activity GSVIVG01030939001 19368167 19376277 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01036524001 23047679 23050334 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01008392001 2561244 2561770 GSVIVG01035242001 11141528 11206907 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01035242001 11141528 11206907 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015232001 1990288 1994730 GSVIVG01034791001 21721612 21721818 GSVIVG01009889001 12146146 12150551 GSVIVG01033412001 20892774 20898343 GO:0006413 translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01033412001 20892774 20898343 GO:0006413 translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. IEA GO:0003743 translation initiation factor activity GSVIVG01012805001 5550176 5552396 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01001537001 1168479 1177103 GSVIVG01031499001 17922335 17929648 Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal. IEA GO:0004462 lactoylglutathione lyase activity GSVIVG01031499001 17922335 17929648 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01011470001 29901640 29908444 GSVIVG01033020001 25100076 25101021 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01033020001 25100076 25101021 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01016421001 4100368 4100783 GSVIVG01008173001 5104509 5107475 GSVIVG01014618001 5754802 5755020 GSVIVG01023939001 2307662 2312585 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01023939001 2307662 2312585 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01023939001 2307662 2312585 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01024586001 8609244 8611522 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids. IEA GO:0004518 nuclease activity GSVIVG01001932001 14952137 14952932 GSVIVG01010239001 18125557 18125798 GSVIVG01015342001 2825909 2830030 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01015342001 2825909 2830030 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01015342001 2825909 2830030 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01015342001 2825909 2830030 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015077001 867704 869890 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01015077001 867704 869890 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01015077001 867704 869890 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01015077001 867704 869890 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022387001 19503364 19537945 GSVIVG01022003001 4400265 4400399 GSVIVG01038243001 24567539 24569053 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01038243001 24567539 24569053 GO:0007047 cellular cell wall organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01038243001 24567539 24569053 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01038243001 24567539 24569053 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01038243001 24567539 24569053 GO:0007047 cellular cell wall organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01038243001 24567539 24569053 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01038243001 24567539 24569053 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01038243001 24567539 24569053 GO:0007047 cellular cell wall organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01038243001 24567539 24569053 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01008761001 1772217 1777433 GO:0042176 regulation of protein catabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0000502 proteasome complex A large multisubunit complex which catalyzes protein degradation. This complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core. IEA Modulates the activity of an enzyme. IEA GO:0030234 enzyme regulator activity GSVIVG01037824001 7446508 7449614 GSVIVG01014074001 150327 151494 GO:0009765 photosynthesis, light harvesting Absorption and transfer of the energy absorbed from light photons between photosystem reaction centers. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01036451001 22173020 22185158 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA GSVIVG01002021001 32332546 32338604 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01002021001 32332546 32338604 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01002021001 32332546 32338604 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01032204001 21571875 21576340 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032204001 21571875 21576340 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032204001 21571875 21576340 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032204001 21571875 21576340 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019940001 4631697 4636037 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01030634001 7336012 7336737 Increases the activity of an enzyme. IEA GO:0008047 enzyme activator activity GSVIVG01024292001 595690 601170 GO:0006559 L-phenylalanine catabolic process The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024292001 595690 601170 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024292001 595690 601170 GO:0006559 L-phenylalanine catabolic process The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of ammonia (NH3) to another substance via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. IEA GO:0016211 ammonia ligase activity GSVIVG01024292001 595690 601170 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of ammonia (NH3) to another substance via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. IEA GO:0016211 ammonia ligase activity GSVIVG01024292001 595690 601170 GO:0006559 L-phenylalanine catabolic process The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate. IEA GO:0016841 ammonia-lyase activity GSVIVG01024292001 595690 601170 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate. IEA GO:0016841 ammonia-lyase activity GSVIVG01031620001 19076702 19078272 GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Prevents the dissociation of GDP from the small GTPase Rho, thereby preventing GTP from binding. IEA GO:0005094 Rho GDP-dissociation inhibitor activity GSVIVG01031386001 19262711 19283747 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01031386001 19262711 19283747 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA Catalysis of the reaction: isopentenyl diphosphate + tRNA = diphosphate + tRNA containing 6-isopentenyladenosine. IEA GO:0004811 tRNA isopentenyltransferase activity GSVIVG01031386001 19262711 19283747 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031386001 19262711 19283747 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01033348001 21316002 21322009 GSVIVG01005195001 19032636 19061384 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01005195001 19032636 19061384 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01005195001 19032636 19061384 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01005195001 19032636 19061384 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01005195001 19032636 19061384 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01005195001 19032636 19061384 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01013113001 8161666 8170322 GSVIVG01011402001 29372192 29377150 GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017944001 4942883 4943919 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009538 photosystem I reaction center A photochemical system containing P700, the chlorophyll a dimer that functions as a primary electron donor. Functioning as a light-dependent plastocyanin-ferredoxin oxidoreductase, it transfers electrons from plastocyanin to ferredoxin. IEA GSVIVG01029354001 15096385 15096735 GSVIVG01004095001 14754334 14757285 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01004095001 14754334 14757285 Catalysis of the elimination of H2S or substituted H2S. IEA GO:0016846 carbon-sulfur lyase activity GSVIVG01004095001 14754334 14757285 Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01001119001 22756441 22763125 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01001119001 22756441 22763125 GO:0006270 DNA-dependent DNA replication initiation The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01001119001 22756441 22763125 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01001119001 22756441 22763125 GO:0006270 DNA-dependent DNA replication initiation The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01001119001 22756441 22763125 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001119001 22756441 22763125 GO:0006270 DNA-dependent DNA replication initiation The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001119001 22756441 22763125 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01001119001 22756441 22763125 GO:0006270 DNA-dependent DNA replication initiation The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01001119001 22756441 22763125 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01001119001 22756441 22763125 GO:0006270 DNA-dependent DNA replication initiation The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01016255001 5890971 5895778 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005945 6-phosphofructokinase complex A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known. IEA Catalysis of the reaction: ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate. IEA GO:0003872 6-phosphofructokinase activity GSVIVG01016255001 5890971 5895778 GO:0006166 purine ribonucleoside salvage Any process which produces a purine nucleoside from derivatives of it, without de novo synthesis. IEA GO:0005945 6-phosphofructokinase complex A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known. IEA Catalysis of the reaction: ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate. IEA GO:0003872 6-phosphofructokinase activity GSVIVG01016255001 5890971 5895778 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005945 6-phosphofructokinase complex A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known. IEA Catalysis of the reaction: ATP + adenosine = ADP + AMP. IEA GO:0004001 adenosine kinase activity GSVIVG01016255001 5890971 5895778 GO:0006166 purine ribonucleoside salvage Any process which produces a purine nucleoside from derivatives of it, without de novo synthesis. IEA GO:0005945 6-phosphofructokinase complex A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known. IEA Catalysis of the reaction: ATP + adenosine = ADP + AMP. IEA GO:0004001 adenosine kinase activity GSVIVG01016210001 6582925 6585234 GO:0045132 meiotic chromosome segregation The process by which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets during M phase of the meiotic cell cycle. IEA GO:0000775 chromosome, centromeric region The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome. IEA GSVIVG01016210001 6582925 6585234 GO:0045132 meiotic chromosome segregation The process by which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets during M phase of the meiotic cell cycle. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01037336001 15544629 15546008 GO:0046080 dUTP metabolic process The chemical reactions and pathways involving dUTP, deoxyuridine (5'-)triphosphate. IEA Catalysis of the reaction: dUTP + H2O = dUMP + diphosphate. IEA GO:0004170 dUTP diphosphatase activity GSVIVG01037336001 15544629 15546008 GO:0046080 dUTP metabolic process The chemical reactions and pathways involving dUTP, deoxyuridine (5'-)triphosphate. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01038203001 24324833 24326672 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01032768001 921564 923771 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01032768001 921564 923771 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01032768001 921564 923771 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01032768001 921564 923771 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032768001 921564 923771 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020371001 20466839 20468202 GSVIVG01013806001 7389744 7409151 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013806001 7389744 7409151 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01035934001 6098327 6100296 GSVIVG01006317001 24859280 24867663 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01006317001 24859280 24867663 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01006317001 24859280 24867663 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01006317001 24859280 24867663 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006317001 24859280 24867663 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01003835001 20530087 20532381 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01003835001 20530087 20532381 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01003835001 20530087 20532381 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01003835001 20530087 20532381 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01001382001 24112494 24114029 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023150001 21925828 21938903 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023150001 21925828 21938903 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01023150001 21925828 21938903 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01023150001 21925828 21938903 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01028787001 18826205 18834557 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01028787001 18826205 18834557 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01028787001 18826205 18834557 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01028787001 18826205 18834557 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01028787001 18826205 18834557 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01028787001 18826205 18834557 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01028787001 18826205 18834557 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028787001 18826205 18834557 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028787001 18826205 18834557 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01028787001 18826205 18834557 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01024457001 2804404 2810828 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01000982001 11123645 11127942 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01000982001 11123645 11127942 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01000982001 11123645 11127942 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01000982001 11123645 11127942 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01000982001 11123645 11127942 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051537 2 iron, 2 sulfur cluster binding GSVIVG01032551001 28292195 28299382 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01032551001 28292195 28299382 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01032551001 28292195 28299382 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032551001 28292195 28299382 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032551001 28292195 28299382 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01032551001 28292195 28299382 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01032551001 28292195 28299382 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01032551001 28292195 28299382 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01027920001 9426104 9432904 GSVIVG01017936001 4860981 4865193 Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01017936001 4860981 4865193 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01032266001 14255666 14282342 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01032266001 14255666 14282342 GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA GSVIVG01025721001 12658421 12660431 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01025721001 12658421 12660431 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01025721001 12658421 12660431 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01014702001 8779485 8786078 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01022341001 18689346 18700808 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01022341001 18689346 18700808 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of a transcription cofactor that activates transcription from a RNA polymerase II promoter; does not bind DNA itself. IEA GO:0003713 transcription coactivator activity GSVIVG01022341001 18689346 18700808 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035308001 258003 279395 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01008884001 3109637 3133801 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0000439 core TFIIH complex The 5 subunit core of TFIIH that has tightly associated subunits and is found in both the general transcription factor holo-TFIIH and in the nucleotide-excision repair factor 3 complex. In S. cerevisiae, it is composed of Rad3, Tfb1, Tfb2, Ssl1, Tfb4. In humans, it is composed of XPD, p62, p55, p44, p34. IEA Any function that supports basal (unregulated) transcription of genes by core RNA polymerase II. Five general transcription factors are necessary and sufficient for such basal transcription in yeast: TFIIB, TFIID, TFIIE, TFIIF, TFIIH and TATA-binding protein (TBF). IEA GO:0016251 general RNA polymerase II transcription factor activity GSVIVG01008884001 3109637 3133801 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0000439 core TFIIH complex The 5 subunit core of TFIIH that has tightly associated subunits and is found in both the general transcription factor holo-TFIIH and in the nucleotide-excision repair factor 3 complex. In S. cerevisiae, it is composed of Rad3, Tfb1, Tfb2, Ssl1, Tfb4. In humans, it is composed of XPD, p62, p55, p44, p34. IEA Any function that supports basal (unregulated) transcription of genes by core RNA polymerase II. Five general transcription factors are necessary and sufficient for such basal transcription in yeast: TFIIB, TFIID, TFIIE, TFIIF, TFIIH and TATA-binding protein (TBF). IEA GO:0016251 general RNA polymerase II transcription factor activity GSVIVG01036649001 19780667 19805748 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01036649001 19780667 19805748 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01036649001 19780667 19805748 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01036649001 19780667 19805748 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01031825001 4712114 4722039 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01031825001 4712114 4722039 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022200001 17404934 17410794 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01022200001 17404934 17410794 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01022200001 17404934 17410794 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01022200001 17404934 17410794 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01030468001 5894237 5922091 GSVIVG01030898001 18602400 18603429 GSVIVG01020015001 11542847 11577704 GSVIVG01022218001 17597074 17604341 GSVIVG01029919001 1482685 1487012 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01029919001 1482685 1487012 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01029919001 1482685 1487012 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01029919001 1482685 1487012 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01030785001 16101492 16116304 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01030785001 16101492 16116304 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01030785001 16101492 16116304 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with prostaglandin E (PGE(2)) to initiate a change in cell activity. IEA GO:0004957 prostaglandin E receptor activity GSVIVG01002623001 35458037 35458909 GO:0008643 carbohydrate transport The directed movement of carbohydrate into, out of, within or between cells by means of some external agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0000139 Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + H+(out) = sugar(in) + H+(in). IEA GO:0005351 sugar:hydrogen symporter activity GSVIVG01002623001 35458037 35458909 GO:0008643 carbohydrate transport The directed movement of carbohydrate into, out of, within or between cells by means of some external agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + H+(out) = sugar(in) + H+(in). IEA GO:0005351 sugar:hydrogen symporter activity GSVIVG01028185001 4476057 4477645 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01016275001 5607745 5613692 GSVIVG01027986001 3007804 3011675 GSVIVG01024306001 706775 713137 GO:0006559 L-phenylalanine catabolic process The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024306001 706775 713137 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024306001 706775 713137 GO:0006559 L-phenylalanine catabolic process The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of ammonia (NH3) to another substance via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. IEA GO:0016211 ammonia ligase activity GSVIVG01024306001 706775 713137 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of ammonia (NH3) to another substance via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. IEA GO:0016211 ammonia ligase activity GSVIVG01024306001 706775 713137 GO:0006559 L-phenylalanine catabolic process The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate. IEA GO:0016841 ammonia-lyase activity GSVIVG01024306001 706775 713137 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate. IEA GO:0016841 ammonia-lyase activity GSVIVG01038338001 13228902 13229275 GSVIVG01008594001 558938 562728 GSVIVG01030920001 18994993 18996040 GSVIVG01001359001 23945318 23946409 GSVIVG01021681001 9265144 9266946 GSVIVG01013328001 12140487 12144524 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01034121001 15022856 15024277 GSVIVG01037901001 6512779 6514995 GSVIVG01011447001 29740180 29742047 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01013553001 20721906 20730141 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01025000001 5386184 5387156 GSVIVG01019101001 16744811 16750076 GSVIVG01010705001 12136240 12137178 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01025893001 27426691 27430888 GSVIVG01004104001 14851614 14852924 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GSVIVG01004104001 14851614 14852924 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GSVIVG01019402001 357129 358775 GSVIVG01004002001 14222879 14224577 GSVIVG01025002001 5365814 5368974 GSVIVG01012679001 603860 605197 GSVIVG01013445001 411861 416076 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01013445001 411861 416076 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01013445001 411861 416076 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01013445001 411861 416076 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01026172001 13405965 13406256 GSVIVG01006319001 24870278 24877944 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01006319001 24870278 24877944 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01006319001 24870278 24877944 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01006319001 24870278 24877944 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01006319001 24870278 24877944 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006319001 24870278 24877944 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01014517001 4722228 4722965 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014517001 4722228 4722965 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025723001 12644630 12650915 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025723001 12644630 12650915 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025723001 12644630 12650915 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025723001 12644630 12650915 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01025723001 12644630 12650915 Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01025723001 12644630 12650915 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01021561001 7080245 7091065 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01021561001 7080245 7091065 Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. IEA GO:0008171 O-methyltransferase activity GSVIVG01021561001 7080245 7091065 The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01004914001 4762059 4762800 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01004914001 4762059 4762800 Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01001274001 4887318 4897426 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001274001 4887318 4897426 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01023291001 20045656 20050279 Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01010509001 21198347 21199218 GSVIVG01001196001 906514 912552 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01001196001 906514 912552 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01001196001 906514 912552 GO:0008272 sulfate transport The directed movement of sulfate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01001196001 906514 912552 GO:0008272 sulfate transport The directed movement of sulfate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01001196001 906514 912552 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01001196001 906514 912552 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01001196001 906514 912552 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01001196001 906514 912552 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01001196001 906514 912552 GO:0008272 sulfate transport The directed movement of sulfate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01001196001 906514 912552 GO:0008272 sulfate transport The directed movement of sulfate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01001196001 906514 912552 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01001196001 906514 912552 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01003988001 26497916 26502682 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01003988001 26497916 26502682 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01014282001 2297284 2302164 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014282001 2297284 2302164 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01031583001 18465326 18470664 GSVIVG01020537001 4693131 4708399 GO:0006662 glycerol ether metabolic process The chemical reactions and pathways involving glycerol ethers, any anhydride formed between two organic hydroxy compounds, one of which is glycerol. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01020537001 4693131 4708399 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01020537001 4693131 4708399 GO:0006662 glycerol ether metabolic process The chemical reactions and pathways involving glycerol ethers, any anhydride formed between two organic hydroxy compounds, one of which is glycerol. IEA Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds. IEA GO:0015035 protein disulfide oxidoreductase activity GSVIVG01020537001 4693131 4708399 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds. IEA GO:0015035 protein disulfide oxidoreductase activity GSVIVG01020787001 1968033 1990170 GO:0030833 regulation of actin filament polymerization Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament. IEA GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01004063001 618444 618958 GSVIVG01033919001 16736059 16737250 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033919001 16736059 16737250 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033919001 16736059 16737250 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033919001 16736059 16737250 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01033919001 16736059 16737250 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01033919001 16736059 16737250 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01033919001 16736059 16737250 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033919001 16736059 16737250 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033919001 16736059 16737250 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033919001 16736059 16737250 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01033919001 16736059 16737250 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01033919001 16736059 16737250 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01033919001 16736059 16737250 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033919001 16736059 16737250 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033919001 16736059 16737250 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031747001 4015610 4023622 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01031747001 4015610 4023622 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01031747001 4015610 4023622 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01031747001 4015610 4023622 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01031747001 4015610 4023622 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031747001 4015610 4023622 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031747001 4015610 4023622 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the endohydrolysis of 1,4-alpha-D-glucosidic linkages in polysaccharides containing three or more 1,4-alpha-linked D-glucose units. IEA GO:0004556 alpha-amylase activity GSVIVG01031747001 4015610 4023622 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Catalysis of the endohydrolysis of 1,4-alpha-D-glucosidic linkages in polysaccharides containing three or more 1,4-alpha-linked D-glucose units. IEA GO:0004556 alpha-amylase activity GSVIVG01031747001 4015610 4023622 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01031747001 4015610 4023622 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01031747001 4015610 4023622 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01031747001 4015610 4023622 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01016794001 1403555 1462243 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016794001 1403555 1462243 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016794001 1403555 1462243 GO:0043254 regulation of protein complex assembly Any process that modulates the frequency, rate or extent of protein complex assembly. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016794001 1403555 1462243 GO:0043254 regulation of protein complex assembly Any process that modulates the frequency, rate or extent of protein complex assembly. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016794001 1403555 1462243 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016794001 1403555 1462243 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016794001 1403555 1462243 GO:0043254 regulation of protein complex assembly Any process that modulates the frequency, rate or extent of protein complex assembly. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016794001 1403555 1462243 GO:0043254 regulation of protein complex assembly Any process that modulates the frequency, rate or extent of protein complex assembly. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016794001 1403555 1462243 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription. IEA GO:0008134 transcription factor binding GSVIVG01016794001 1403555 1462243 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription. IEA GO:0008134 transcription factor binding GSVIVG01016794001 1403555 1462243 GO:0043254 regulation of protein complex assembly Any process that modulates the frequency, rate or extent of protein complex assembly. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription. IEA GO:0008134 transcription factor binding GSVIVG01016794001 1403555 1462243 GO:0043254 regulation of protein complex assembly Any process that modulates the frequency, rate or extent of protein complex assembly. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription. IEA GO:0008134 transcription factor binding GSVIVG01016794001 1403555 1462243 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01016794001 1403555 1462243 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01016794001 1403555 1462243 GO:0043254 regulation of protein complex assembly Any process that modulates the frequency, rate or extent of protein complex assembly. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01016794001 1403555 1462243 GO:0043254 regulation of protein complex assembly Any process that modulates the frequency, rate or extent of protein complex assembly. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01016794001 1403555 1462243 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01016794001 1403555 1462243 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01016794001 1403555 1462243 GO:0043254 regulation of protein complex assembly Any process that modulates the frequency, rate or extent of protein complex assembly. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01016794001 1403555 1462243 GO:0043254 regulation of protein complex assembly Any process that modulates the frequency, rate or extent of protein complex assembly. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01028056001 3484635 3492244 GO:0006099 tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. IEA GO:0045239 tricarboxylic acid cycle enzyme complex Any of the heteromeric enzymes that act in the TCA cycle. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028056001 3484635 3492244 GO:0006106 fumarate metabolic process The chemical reactions and pathways involving fumarate, the anion of trans-1,2-ethenedicarboxylic acid, the diastereoisomer of maleate. It is a key intermediate in metabolism and is formed in the TCA cycle from succinate and converted into malate. IEA GO:0045239 tricarboxylic acid cycle enzyme complex Any of the heteromeric enzymes that act in the TCA cycle. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028056001 3484635 3492244 GO:0006099 tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. IEA GO:0045239 tricarboxylic acid cycle enzyme complex Any of the heteromeric enzymes that act in the TCA cycle. IEA Catalysis of the reaction: (S)-malate = fumarate + H2O. IEA GO:0004333 fumarate hydratase activity GSVIVG01028056001 3484635 3492244 GO:0006106 fumarate metabolic process The chemical reactions and pathways involving fumarate, the anion of trans-1,2-ethenedicarboxylic acid, the diastereoisomer of maleate. It is a key intermediate in metabolism and is formed in the TCA cycle from succinate and converted into malate. IEA GO:0045239 tricarboxylic acid cycle enzyme complex Any of the heteromeric enzymes that act in the TCA cycle. IEA Catalysis of the reaction: (S)-malate = fumarate + H2O. IEA GO:0004333 fumarate hydratase activity GSVIVG01028056001 3484635 3492244 GO:0006099 tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. IEA GO:0045239 tricarboxylic acid cycle enzyme complex Any of the heteromeric enzymes that act in the TCA cycle. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01028056001 3484635 3492244 GO:0006106 fumarate metabolic process The chemical reactions and pathways involving fumarate, the anion of trans-1,2-ethenedicarboxylic acid, the diastereoisomer of maleate. It is a key intermediate in metabolism and is formed in the TCA cycle from succinate and converted into malate. IEA GO:0045239 tricarboxylic acid cycle enzyme complex Any of the heteromeric enzymes that act in the TCA cycle. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01029122001 19367554 19383291 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01029122001 19367554 19383291 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01029122001 19367554 19383291 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01009910001 12310191 12311438 GSVIVG01001443001 21061396 21064083 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids. IEA GO:0004518 nuclease activity GSVIVG01023011001 16911990 16916212 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023011001 16911990 16916212 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023011001 16911990 16916212 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023011001 16911990 16916212 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025951001 26762452 26767772 GSVIVG01019241001 2868334 2869872 GSVIVG01020577001 4129420 4133784 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01020577001 4129420 4133784 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01020577001 4129420 4133784 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033548001 19843662 19845717 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01033548001 19843662 19845717 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01033548001 19843662 19845717 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01033548001 19843662 19845717 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01033548001 19843662 19845717 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01033548001 19843662 19845717 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01033548001 19843662 19845717 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01033548001 19843662 19845717 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01033548001 19843662 19845717 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01033548001 19843662 19845717 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01033548001 19843662 19845717 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01033548001 19843662 19845717 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01033548001 19843662 19845717 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01033548001 19843662 19845717 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01033548001 19843662 19845717 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01033548001 19843662 19845717 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01033548001 19843662 19845717 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01033548001 19843662 19845717 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01032691001 1500355 1501104 GSVIVG01003750001 12355081 12360881 GSVIVG01033968001 16220670 16222595 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0008236 serine-type peptidase activity GSVIVG01007641001 10911781 10912037 GSVIVG01014451001 3867295 3892849 GO:0007205 activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway The initiation of the activity of the inactive enzyme protein kinase C as the result of a series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol 3-phosphate. IEA GO:0004143 diacylglycerol kinase activity GSVIVG01020970001 16133405 16134289 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016784001 1335706 1341591 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: phosphatidylcholine + a sterol = a sterol ester + 1-acylglycerophosphocholine. IEA GO:0004607 phosphatidylcholine-sterol O-acyltransferase activity GSVIVG01010216001 17753386 17754738 GSVIVG01017757001 3181986 3182859 GSVIVG01013107001 8222938 8233818 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01013107001 8222938 8233818 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01020140001 9913225 9913383 GSVIVG01037172001 28333116 28333499 GSVIVG01016887001 2271830 2274414 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01016887001 2271830 2274414 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01010403001 20218414 20218530 GSVIVG01000855001 3069367 3070227 GSVIVG01016433001 3948327 3965862 GSVIVG01033338001 21367807 21372343 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01033338001 21367807 21372343 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01033338001 21367807 21372343 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01033338001 21367807 21372343 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023956001 2183381 2192025 GSVIVG01021140001 1764407 1781679 GSVIVG01025118001 4276489 4282447 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: prephenate = phenylpyruvate + H2O + CO2. IEA GO:0004664 prephenate dehydratase activity GSVIVG01025118001 4276489 4282447 GO:0009094 L-phenylalanine biosynthetic process The chemical reactions and pathways resulting in the formation of L-phenylalanine, the L-enantiomer of 2-amino-3-phenylpropanoic acid, i.e. (2S)-2-amino-3-phenylpropanoic acid. IEA Catalysis of the reaction: prephenate = phenylpyruvate + H2O + CO2. IEA GO:0004664 prephenate dehydratase activity GSVIVG01025118001 4276489 4282447 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. IEA GO:0016597 amino acid binding GSVIVG01025118001 4276489 4282447 GO:0009094 L-phenylalanine biosynthetic process The chemical reactions and pathways resulting in the formation of L-phenylalanine, the L-enantiomer of 2-amino-3-phenylpropanoic acid, i.e. (2S)-2-amino-3-phenylpropanoic acid. IEA Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. IEA GO:0016597 amino acid binding GSVIVG01015102001 1057782 1067052 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01009142001 5482254 5484157 GSVIVG01019379001 97371 99713 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019379001 97371 99713 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01032692001 1496969 1497976 GSVIVG01010795001 22653580 22654859 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01019800001 3441922 3442763 GSVIVG01036548001 23305690 23319921 GSVIVG01031435001 18608990 18631085 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0008236 serine-type peptidase activity GSVIVG01019416001 488930 493430 GSVIVG01015570001 5038248 5051298 GO:0006414 translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Functions in chain elongation during polypeptide synthesis at the ribosome. IEA GO:0003746 translation elongation factor activity GSVIVG01025711001 12759751 12765914 Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01024858001 6409118 6417495 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01020369001 20474464 20474631 GSVIVG01003472001 10573967 10576448 GSVIVG01034394001 16872736 16875473 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01034394001 16872736 16875473 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01025955001 26685498 26687218 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020417001 19783335 19783547 GSVIVG01026020001 25797007 25807616 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01026020001 25797007 25807616 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01026020001 25797007 25807616 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01026020001 25797007 25807616 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026020001 25797007 25807616 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001875001 6576415 6577083 GSVIVG01015557001 4870814 4902543 GSVIVG01032372001 26786170 26786504 GSVIVG01006086001 41250321 41251170 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a nucleotidyl group to a reactant. IEA GO:0016779 nucleotidyltransferase activity GSVIVG01032219001 13107508 13112467 GSVIVG01011730001 4732749 4737395 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GSVIVG01011730001 4732749 4737395 GO:0009607 response to biotic stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism. IEA GSVIVG01003229001 14274407 14275715 GSVIVG01015979001 16741106 16741955 Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01015979001 16741106 16741955 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01009691001 10516738 10517835 GSVIVG01014902001 11491791 11505091 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01014902001 11491791 11505091 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01014902001 11491791 11505091 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01014902001 11491791 11505091 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01025271001 2559990 2565428 GSVIVG01010947001 2748655 2749685 GSVIVG01030750001 15274075 15275507 GSVIVG01026703001 5087915 5088931 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01026703001 5087915 5088931 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01018497001 14299091 14299549 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01018497001 14299091 14299549 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01024559001 8848747 8857227 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01024559001 8848747 8857227 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01013175001 7118008 7119801 GO:0006546 glycine catabolic process The chemical reactions and pathways resulting in the breakdown of glycine, aminoethanoic acid. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with lipoic acid, 1,2-dithiolane-3-pentanoic acid. IEA GO:0031405 lipoic acid binding GSVIVG01013175001 7118008 7119801 GO:0006546 glycine catabolic process The chemical reactions and pathways resulting in the breakdown of glycine, aminoethanoic acid. IEA GO:0005960 glycine cleavage complex A protein complex that catalyzes the reversible oxidation of glycine. In E. coli, it has four components: dihydrolipoamide dehydrogenase, glycine dehydrogenase (decarboxylating), lipoyl-GcvH-protein and aminomethyltransferase, also known as L, P, H, and T. IEA Interacting selectively and non-covalently with lipoic acid, 1,2-dithiolane-3-pentanoic acid. IEA GO:0031405 lipoic acid binding GSVIVG01013175001 7118008 7119801 GO:0019464 glycine decarboxylation via glycine cleavage system The chemical reactions and pathways resulting in the breakdown of glycine by oxidative cleavage to carbon dioxide, ammonia, and a methylene group, mediated by enzymes of the glycine cleavage complex. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with lipoic acid, 1,2-dithiolane-3-pentanoic acid. IEA GO:0031405 lipoic acid binding GSVIVG01013175001 7118008 7119801 GO:0019464 glycine decarboxylation via glycine cleavage system The chemical reactions and pathways resulting in the breakdown of glycine by oxidative cleavage to carbon dioxide, ammonia, and a methylene group, mediated by enzymes of the glycine cleavage complex. IEA GO:0005960 glycine cleavage complex A protein complex that catalyzes the reversible oxidation of glycine. In E. coli, it has four components: dihydrolipoamide dehydrogenase, glycine dehydrogenase (decarboxylating), lipoyl-GcvH-protein and aminomethyltransferase, also known as L, P, H, and T. IEA Interacting selectively and non-covalently with lipoic acid, 1,2-dithiolane-3-pentanoic acid. IEA GO:0031405 lipoic acid binding GSVIVG01037553001 11511855 11512754 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01037553001 11511855 11512754 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000271001 20914629 20915624 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01000271001 20914629 20915624 GO:0016570 histone modification The covalent alteration of one or more amino acid residues within a histone protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01031076001 21884233 21900586 GSVIVG01029089001 12321477 12325195 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01029089001 12321477 12325195 GO:0042765 GPI-anchor transamidase complex An enzyme complex which in humans and yeast consists of at least five proteins; for example, the complex contains GAA1, GPI8, PIG-S, PIG-U, and PIG-T in human, and Gaa1p, Gab1p, Gpi8p, Gpi16p, and Gpi17p in yeast. Catalyzes the posttranslational attachment of the carboxyl-terminus of a precursor protein to a GPI-anchor. IEA GSVIVG01027206001 18318605 18321630 GSVIVG01002105001 32965255 32967811 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01002105001 32965255 32967811 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01002105001 32965255 32967811 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01002105001 32965255 32967811 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01002105001 32965255 32967811 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01002105001 32965255 32967811 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01002105001 32965255 32967811 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01002105001 32965255 32967811 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01002105001 32965255 32967811 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01002105001 32965255 32967811 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01025473001 519784 531794 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025473001 519784 531794 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025473001 519784 531794 GO:0006422 aspartyl-tRNA aminoacylation The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025473001 519784 531794 GO:0006430 lysyl-tRNA aminoacylation The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025473001 519784 531794 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01025473001 519784 531794 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01025473001 519784 531794 GO:0006422 aspartyl-tRNA aminoacylation The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01025473001 519784 531794 GO:0006430 lysyl-tRNA aminoacylation The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01025473001 519784 531794 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01025473001 519784 531794 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01025473001 519784 531794 GO:0006422 aspartyl-tRNA aminoacylation The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01025473001 519784 531794 GO:0006430 lysyl-tRNA aminoacylation The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01025473001 519784 531794 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp). IEA GO:0004815 aspartate-tRNA ligase activity GSVIVG01025473001 519784 531794 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp). IEA GO:0004815 aspartate-tRNA ligase activity GSVIVG01025473001 519784 531794 GO:0006422 aspartyl-tRNA aminoacylation The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp). IEA GO:0004815 aspartate-tRNA ligase activity GSVIVG01025473001 519784 531794 GO:0006430 lysyl-tRNA aminoacylation The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp). IEA GO:0004815 aspartate-tRNA ligase activity GSVIVG01025473001 519784 531794 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys). IEA GO:0004824 lysine-tRNA ligase activity GSVIVG01025473001 519784 531794 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys). IEA GO:0004824 lysine-tRNA ligase activity GSVIVG01025473001 519784 531794 GO:0006422 aspartyl-tRNA aminoacylation The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys). IEA GO:0004824 lysine-tRNA ligase activity GSVIVG01025473001 519784 531794 GO:0006430 lysyl-tRNA aminoacylation The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys). IEA GO:0004824 lysine-tRNA ligase activity GSVIVG01025473001 519784 531794 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025473001 519784 531794 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025473001 519784 531794 GO:0006422 aspartyl-tRNA aminoacylation The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025473001 519784 531794 GO:0006430 lysyl-tRNA aminoacylation The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025473001 519784 531794 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01025473001 519784 531794 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01025473001 519784 531794 GO:0006422 aspartyl-tRNA aminoacylation The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01025473001 519784 531794 GO:0006430 lysyl-tRNA aminoacylation The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01023418001 12362322 12363936 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with follicle-stimulating hormone to initiate a change in cell activity. IEA GO:0004963 follicle-stimulating hormone receptor activity GSVIVG01017573001 10807238 10834563 GSVIVG01025370001 1350308 1408792 GO:0006075 1,3-beta-glucan biosynthetic process The chemical reactions and pathways resulting in the formation of beta-1,3 glucans, compounds composed of glucose residues linked by 1,3-beta-D-glucosidic bonds. IEA GO:0000148 1,3-beta-glucan synthase complex A protein complex that catalyzes the transfer of a glucose moiety from UDP-glucose to a 1,3-beta-D-glucan chain. IEA Catalysis of the reaction: UDP-glucose + 1,3-beta-D-glucosyl(n) = UDP + 1,3-beta-D-glucosyl(n+1). IEA GO:0003843 1,3-beta-glucan synthase activity GSVIVG01025370001 1350308 1408792 GO:0006075 1,3-beta-glucan biosynthetic process The chemical reactions and pathways resulting in the formation of beta-1,3 glucans, compounds composed of glucose residues linked by 1,3-beta-D-glucosidic bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: UDP-glucose + 1,3-beta-D-glucosyl(n) = UDP + 1,3-beta-D-glucosyl(n+1). IEA GO:0003843 1,3-beta-glucan synthase activity GSVIVG01034776001 21226918 21227698 GSVIVG01024737001 7343400 7347996 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01024737001 7343400 7347996 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01036253001 8026997 8027743 GSVIVG01035035001 1063648 1068307 GSVIVG01007814001 8770928 8775610 GSVIVG01013874001 5800268 5801224 Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01013874001 5800268 5801224 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01034860001 22937010 22942889 GSVIVG01032934001 24308617 24313599 GSVIVG01008369001 2767985 2782669 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01008369001 2767985 2782669 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01008369001 2767985 2782669 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01008369001 2767985 2782669 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01017775001 3389001 3401752 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01017775001 3389001 3401752 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01017775001 3389001 3401752 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01007407001 31676408 31677412 GO:0006298 mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007407001 31676408 31677412 GO:0006298 mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. IEA Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches. IEA GO:0030983 mismatched DNA binding GSVIVG01034558001 19481412 19491537 GO:0006397 mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01034558001 19481412 19491537 GO:0006397 mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01034558001 19481412 19491537 GO:0006397 mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01035896001 5458050 5460205 GSVIVG01001527001 1028877 1032694 GSVIVG01016437001 3919930 3920689 GSVIVG01025764001 12127838 12130438 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004185 serine-type carboxypeptidase activity GSVIVG01023518001 10528350 10528502 GSVIVG01023911001 2525431 2527246 GSVIVG01037654001 6584228 6586583 GSVIVG01003098001 8676779 8678866 GSVIVG01022410001 19815289 19833299 GSVIVG01014184001 1320870 1322474 GSVIVG01015901001 19077045 19089362 GSVIVG01011914001 3044555 3045863 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01001307001 5185047 5189256 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01001307001 5185047 5189256 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01032328001 15103117 15104459 GSVIVG01026599001 21178401 21181027 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01024911001 6103856 6105883 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01036683001 23921594 23931529 GO:0006221 pyrimidine nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01036683001 23921594 23931529 GO:0006541 glutamine metabolic process The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01036683001 23921594 23931529 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01036683001 23921594 23931529 GO:0006221 pyrimidine nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. IEA Catalysis of the reaction: ATP + UTP + NH3 = ADP + phosphate + CTP. IEA GO:0003883 CTP synthase activity GSVIVG01036683001 23921594 23931529 GO:0006541 glutamine metabolic process The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid. IEA Catalysis of the reaction: ATP + UTP + NH3 = ADP + phosphate + CTP. IEA GO:0003883 CTP synthase activity GSVIVG01036683001 23921594 23931529 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: ATP + UTP + NH3 = ADP + phosphate + CTP. IEA GO:0003883 CTP synthase activity GSVIVG01036683001 23921594 23931529 GO:0006221 pyrimidine nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01036683001 23921594 23931529 GO:0006541 glutamine metabolic process The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01036683001 23921594 23931529 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01004335001 38137523 38138818 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GSVIVG01013321001 11906426 11907092 GSVIVG01001808001 25982850 25986826 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA GSVIVG01034256001 13601871 13602288 GSVIVG01009725001 10817885 10823444 GSVIVG01013159001 7397010 7400572 GSVIVG01012920001 13472783 13473557 Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides. IEA GO:0004866 endopeptidase inhibitor activity GSVIVG01037349001 15354032 15355836 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Stops, prevents or reduces the activity of an enzyme. IEA GO:0004857 enzyme inhibitor activity GSVIVG01037349001 15354032 15355836 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01037349001 15354032 15355836 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the reaction: pectin + n H2O = n methanol + pectate. IEA GO:0030599 pectinesterase activity GSVIVG01037349001 15354032 15355836 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue. IEA GO:0045330 aspartyl esterase activity GSVIVG01037729001 7295393 7306698 GSVIVG01009819001 11528060 11539400 GSVIVG01009712001 10682033 10684613 GSVIVG01029697001 13309190 13340698 GSVIVG01029294001 17394963 17396128 GO:0046836 glycolipid transport The directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Enables the directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of, within or between cells. IEA GO:0017089 glycolipid transporter activity GSVIVG01029294001 17394963 17396128 GO:0046836 glycolipid transport The directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a glycolipid, any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic moiety such as an acylglycerol, a sphingoid, a ceramide (N-acylsphingoid) or a prenyl phosphate. IEA GO:0051861 glycolipid binding GSVIVG01033624001 19147149 19151531 GO:0046488 phosphatidylinositol metabolic process The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. IEA Catalysis of the phosphorylation of phosphatidylinositol phosphate to produce phosphatidylinositol bisphosphate. IEA GO:0016307 phosphatidylinositol phosphate kinase activity GSVIVG01028481001 8154940 8156453 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028481001 8154940 8156453 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009538 photosystem I reaction center A photochemical system containing P700, the chlorophyll a dimer that functions as a primary electron donor. Functioning as a light-dependent plastocyanin-ferredoxin oxidoreductase, it transfers electrons from plastocyanin to ferredoxin. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01034469001 20835993 20839675 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0008021 synaptic vesicle A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and is secreted these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01034469001 20835993 20839675 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01032661001 1719393 1720884 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01032661001 1719393 1720884 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01016858001 2047141 2048252 GSVIVG01025963001 26551814 26556622 GSVIVG01035071001 1295957 1296900 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GSVIVG01035071001 1295957 1296900 GO:0009607 response to biotic stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism. IEA GSVIVG01036513001 22886539 22892291 GSVIVG01000036001 2963254 2966335 Catalysis of the transfer of the amide nitrogen of glutamine to a variety of substrates. GATases catalyze two separate reactions at two active sites, which are located either on a single polypeptide chain or on different subunits. In the glutaminase reaction, glutamine is hydrolyzed to glutamate and ammonia, which is added to an acceptor substrate in the synthase reaction. IEA GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor GSVIVG01014924001 12105537 12106649 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014924001 12105537 12106649 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030132 clathrin coat of coated pit The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014924001 12105537 12106649 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014924001 12105537 12106649 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030132 clathrin coat of coated pit The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014924001 12105537 12106649 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014924001 12105537 12106649 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030132 clathrin coat of coated pit The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029911001 1333008 1342474 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01029911001 1333008 1342474 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01029911001 1333008 1342474 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01029911001 1333008 1342474 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01019976001 12125592 12127646 GSVIVG01007597001 11456925 11462413 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01007597001 11456925 11462413 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01018513001 14008044 14017362 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01006162001 42292365 42293860 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin. IEA GO:0004221 ubiquitin thiolesterase activity GSVIVG01031837001 4782181 4783671 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01031837001 4782181 4783671 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01032413001 27132899 27138271 GSVIVG01010684001 11683311 11716069 GSVIVG01008315001 3340206 3341555 GSVIVG01019810001 3512888 3513635 GSVIVG01032530001 28134293 28138524 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion. IEA GO:0004806 triglyceride lipase activity GSVIVG01029502001 22233618 22234236 GSVIVG01027325001 16597216 16599226 GSVIVG01036154001 20025175 20027827 GSVIVG01010942001 2806880 2808331 GSVIVG01004708001 15413347 15413625 GSVIVG01002415001 34678525 34691520 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01002415001 34678525 34691520 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01002415001 34678525 34691520 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01002415001 34678525 34691520 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01022322001 18472880 18488313 Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01016562001 2759190 2766414 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016562001 2759190 2766414 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01029646001 20257761 20263983 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029849001 395848 396495 GO:0009269 response to desiccation A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a desiccation stimulus, extreme dryness resulting from the prolonged deprivation of water. IEA GSVIVG01010624001 15902691 15905737 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01008839001 2643129 2645286 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01021487001 6065144 6065526 GSVIVG01026999001 18677472 18680014 GSVIVG01006276001 24430692 24434415 GSVIVG01032642001 1906488 1911827 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01032642001 1906488 1911827 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01032642001 1906488 1911827 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01032642001 1906488 1911827 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008123001 5591661 5598435 GSVIVG01034822001 22105717 22125120 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01034822001 22105717 22125120 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01000318001 11323178 11325059 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01034259001 13611286 13614883 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01032159001 22015801 22016328 GSVIVG01028503001 8671643 8672427 GSVIVG01014087001 276078 276974 GSVIVG01034502001 20255146 20255684 GSVIVG01034521001 19919285 19920665 GSVIVG01035658001 3080419 3083398 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026012001 25876232 25883232 GSVIVG01030126001 10074741 10077272 GSVIVG01014339001 2780604 2788637 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005758 mitochondrial intermembrane space The region between the inner and outer lipid bilayers of the mitochondrial envelope. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01014339001 2780604 2788637 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005758 mitochondrial intermembrane space The region between the inner and outer lipid bilayers of the mitochondrial envelope. IEA Assists in the delivery of copper ions to target proteins or compartments. IEA GO:0016531 copper chaperone activity GSVIVG01035444001 1307401 1313986 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. IEA GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GSVIVG01005260001 19963061 19964599 GSVIVG01019826001 3670619 3678500 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01019826001 3670619 3678500 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01004277001 37918999 37920713 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01004277001 37918999 37920713 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01004277001 37918999 37920713 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01004277001 37918999 37920713 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01025864001 11072168 11076187 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01025864001 11072168 11076187 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01025864001 11072168 11076187 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01025864001 11072168 11076187 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01008706001 1343783 1349354 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01008706001 1343783 1349354 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01008706001 1343783 1349354 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01008706001 1343783 1349354 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01008706001 1343783 1349354 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01008706001 1343783 1349354 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01006336001 276272 277126 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01003857001 12921201 12930783 GO:0006544 glycine metabolic process The chemical reactions and pathways involving glycine, aminoethanoic acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003857001 12921201 12930783 GO:0006563 L-serine metabolic process The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003857001 12921201 12930783 GO:0006544 glycine metabolic process The chemical reactions and pathways involving glycine, aminoethanoic acid. IEA Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine. IEA GO:0004372 glycine hydroxymethyltransferase activity GSVIVG01003857001 12921201 12930783 GO:0006563 L-serine metabolic process The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. IEA Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine. IEA GO:0004372 glycine hydroxymethyltransferase activity GSVIVG01003857001 12921201 12930783 GO:0006544 glycine metabolic process The chemical reactions and pathways involving glycine, aminoethanoic acid. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01003857001 12921201 12930783 GO:0006563 L-serine metabolic process The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01032801001 634967 637346 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01032801001 634967 637346 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA A ligand-dependent receptor found in the nucleus of the cell. IEA GO:0004879 ligand-dependent nuclear receptor activity GSVIVG01011356001 28923786 28926499 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01011356001 28923786 28926499 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01031397001 19128226 19130406 GSVIVG01003085001 8510518 8530563 GSVIVG01004091001 14725408 14730543 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01004091001 14725408 14730543 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01004091001 14725408 14730543 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01004091001 14725408 14730543 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01004091001 14725408 14730543 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01004091001 14725408 14730543 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01004091001 14725408 14730543 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01004091001 14725408 14730543 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001532001 1060409 1079555 GO:0019836 hemolysis by symbiont of host erythrocytes The cytolytic destruction of red blood cells, with the release of intracellular hemoglobin, in the host organism by a symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01001532001 1060409 1079555 GO:0032259 methylation The process by which a methyl group is covalently attached to a molecule. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01001532001 1060409 1079555 GO:0019836 hemolysis by symbiont of host erythrocytes The cytolytic destruction of red blood cells, with the release of intracellular hemoglobin, in the host organism by a symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01001532001 1060409 1079555 GO:0032259 methylation The process by which a methyl group is covalently attached to a molecule. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01001532001 1060409 1079555 GO:0019836 hemolysis by symbiont of host erythrocytes The cytolytic destruction of red blood cells, with the release of intracellular hemoglobin, in the host organism by a symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01001532001 1060409 1079555 GO:0032259 methylation The process by which a methyl group is covalently attached to a molecule. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01006215001 23722974 23730409 GSVIVG01024556001 8869213 8870029 GSVIVG01010102001 15492099 15497110 GSVIVG01022092001 16513178 16526395 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01004820001 165459 172140 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005945 6-phosphofructokinase complex A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known. IEA Catalysis of the reaction: ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate. IEA GO:0003872 6-phosphofructokinase activity GSVIVG01004820001 165459 172140 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005945 6-phosphofructokinase complex A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01004820001 165459 172140 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005945 6-phosphofructokinase complex A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known. IEA Catalysis of the reaction: fructose-6-phosphate + pyrophosphate = phosphate + fructose-1,6-bisphosphate. IEA GO:0047334 diphosphate-fructose-6-phosphate 1-phosphotransferase activity GSVIVG01028627001 11128916 11131720 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028627001 11128916 11131720 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036481001 22560983 22561672 GSVIVG01025079001 4680709 4737715 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025079001 4680709 4737715 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01025079001 4680709 4737715 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01025079001 4680709 4737715 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a ribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to ribose. IEA GO:0032549 ribonucleoside binding GSVIVG01004947001 16901918 16902463 GSVIVG01011893001 3232043 3232586 GSVIVG01035445001 1328147 1329643 GSVIVG01015143001 1339868 1340842 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA GSVIVG01032484001 27789154 27791564 GSVIVG01036802001 22358835 22361459 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01022228001 17684914 17685039 GSVIVG01026281001 15521671 15522975 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01038622001 21394851 21395632 GSVIVG01033531001 19963578 19968092 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01033531001 19963578 19968092 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01033531001 19963578 19968092 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01011430001 29590446 29598453 GSVIVG01028963001 17034501 17035794 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01005965001 23007685 23008046 GSVIVG01024001001 1808726 1814064 GSVIVG01011475001 29931446 29932643 Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01011475001 29931446 29932643 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01016803001 1536336 1536533 GSVIVG01005700001 21368351 21379232 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01014136001 715872 718033 GSVIVG01003545001 14498837 14502532 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01003545001 14498837 14502532 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01003545001 14498837 14502532 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with 5S ribosomal RNA, the smallest RNA constituent of a ribosome. IEA GO:0008097 5S rRNA binding GSVIVG01003545001 14498837 14502532 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with 5S ribosomal RNA, the smallest RNA constituent of a ribosome. IEA GO:0008097 5S rRNA binding GSVIVG01017112001 4256419 4258535 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012651001 354675 360493 GO:0001522 pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01012651001 354675 360493 GO:0009451 RNA modification The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01012651001 354675 360493 GO:0001522 pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs. IEA Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. IEA GO:0009982 pseudouridine synthase activity GSVIVG01012651001 354675 360493 GO:0009451 RNA modification The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. IEA Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. IEA GO:0009982 pseudouridine synthase activity GSVIVG01014898001 11389454 11390359 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014898001 11389454 11390359 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030132 clathrin coat of coated pit The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014898001 11389454 11390359 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014898001 11389454 11390359 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030132 clathrin coat of coated pit The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036362001 4225053 4229977 GO:0030833 regulation of actin filament polymerization Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament. IEA GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01036362001 4225053 4229977 GO:0030833 regulation of actin filament polymerization Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament. IEA GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036362001 4225053 4229977 GO:0030833 regulation of actin filament polymerization Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament. IEA GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028516001 9033294 9038033 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01033500001 20225346 20226151 GSVIVG01027449001 16656671 16659811 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01027449001 16656671 16659811 Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. IEA GO:0008171 O-methyltransferase activity GSVIVG01027449001 16656671 16659811 The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01001036001 6734976 6738952 GO:0006120 mitochondrial electron transport, NADH to ubiquinone The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex I. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01001036001 6734976 6738952 GO:0006120 mitochondrial electron transport, NADH to ubiquinone The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex I. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01001036001 6734976 6738952 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01001036001 6734976 6738952 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01001036001 6734976 6738952 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01001036001 6734976 6738952 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01001036001 6734976 6738952 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01001036001 6734976 6738952 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01001036001 6734976 6738952 GO:0006120 mitochondrial electron transport, NADH to ubiquinone The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex I. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. IEA GO:0008137 NADH dehydrogenase (ubiquinone) activity GSVIVG01001036001 6734976 6738952 GO:0006120 mitochondrial electron transport, NADH to ubiquinone The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex I. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. IEA GO:0008137 NADH dehydrogenase (ubiquinone) activity GSVIVG01001036001 6734976 6738952 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. IEA GO:0008137 NADH dehydrogenase (ubiquinone) activity GSVIVG01001036001 6734976 6738952 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. IEA GO:0008137 NADH dehydrogenase (ubiquinone) activity GSVIVG01001036001 6734976 6738952 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. IEA GO:0008137 NADH dehydrogenase (ubiquinone) activity GSVIVG01001036001 6734976 6738952 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. IEA GO:0008137 NADH dehydrogenase (ubiquinone) activity GSVIVG01001036001 6734976 6738952 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. IEA GO:0008137 NADH dehydrogenase (ubiquinone) activity GSVIVG01001036001 6734976 6738952 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. IEA GO:0008137 NADH dehydrogenase (ubiquinone) activity GSVIVG01001036001 6734976 6738952 GO:0006120 mitochondrial electron transport, NADH to ubiquinone The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex I. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01001036001 6734976 6738952 GO:0006120 mitochondrial electron transport, NADH to ubiquinone The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex I. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01001036001 6734976 6738952 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01001036001 6734976 6738952 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01001036001 6734976 6738952 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01001036001 6734976 6738952 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01001036001 6734976 6738952 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01001036001 6734976 6738952 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01020258001 22157769 22166597 GSVIVG01037455001 13395799 13420376 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01000687001 15497729 15499650 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01000687001 15497729 15499650 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01036367001 4279081 4283805 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01036367001 4279081 4283805 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01034157001 14779998 14783158 GSVIVG01038733001 57185 62410 GSVIVG01026316001 13548759 13552463 GSVIVG01003181001 7629427 7632391 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01003181001 7629427 7632391 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01003181001 7629427 7632391 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01003181001 7629427 7632391 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01028546001 9527995 9534375 GSVIVG01027914001 9334528 9334821 GSVIVG01023813001 3277622 3287627 GO:0009089 lysine biosynthetic process via diaminopimelate The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01023813001 3277622 3287627 GO:0009089 lysine biosynthetic process via diaminopimelate The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate. IEA Catalysis of the reaction: meso-2,6-diaminoheptanedioate = L-lysine + CO2. IEA GO:0008836 diaminopimelate decarboxylase activity GSVIVG01022187001 17275746 17288313 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01021142001 1786736 1791149 GSVIVG01025424001 896594 897171 GSVIVG01026610001 21075195 21076353 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01031145001 1745796 1757407 GSVIVG01023740001 10399594 10405950 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01023740001 10399594 10405950 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01023740001 10399594 10405950 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01023740001 10399594 10405950 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01023740001 10399594 10405950 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01023740001 10399594 10405950 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01023740001 10399594 10405950 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01023740001 10399594 10405950 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01023740001 10399594 10405950 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01023740001 10399594 10405950 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01023740001 10399594 10405950 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01023740001 10399594 10405950 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01019088001 16811746 16815368 GSVIVG01003878001 13065170 13065427 GSVIVG01015980001 16750977 16756114 GSVIVG01010767001 22409257 22415852 GSVIVG01016362001 4509785 4511411 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01029218001 18423129 18429414 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01003968001 26380212 26387634 GSVIVG01038116001 23589671 23590613 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01038116001 23589671 23590613 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01038116001 23589671 23590613 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01027751001 7405376 7407224 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01018906001 18747649 18748758 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01014619001 5755026 5759869 GSVIVG01023615001 8058260 8066363 GSVIVG01035853001 4893677 4897069 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035853001 4893677 4897069 GO:0046470 phosphatidylcholine metabolic process The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035853001 4893677 4897069 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate. IEA GO:0004630 phospholipase D activity GSVIVG01035853001 4893677 4897069 GO:0046470 phosphatidylcholine metabolic process The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate. IEA GO:0004630 phospholipase D activity GSVIVG01035853001 4893677 4897069 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01035853001 4893677 4897069 GO:0046470 phosphatidylcholine metabolic process The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01020174001 9424059 9437701 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01020174001 9424059 9437701 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01020174001 9424059 9437701 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01020174001 9424059 9437701 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01020174001 9424059 9437701 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and primer. IEA GO:0003887 DNA-directed DNA polymerase activity GSVIVG01020174001 9424059 9437701 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and primer. IEA GO:0003887 DNA-directed DNA polymerase activity GSVIVG01020174001 9424059 9437701 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). IEA GO:0003912 DNA nucleotidylexotransferase activity GSVIVG01020174001 9424059 9437701 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). IEA GO:0003912 DNA nucleotidylexotransferase activity GSVIVG01006527001 42889328 42889702 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01000253001 20563594 20582990 GSVIVG01019501001 1157541 1162045 GSVIVG01018743001 20263133 20278688 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01018743001 20263133 20278688 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01018743001 20263133 20278688 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01018743001 20263133 20278688 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01025930001 27122027 27124079 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025930001 27122027 27124079 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0010181 FMN binding GSVIVG01025930001 27122027 27124079 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021462001 5655457 5657121 GSVIVG01029082001 12156030 12156413 GSVIVG01001754001 6097809 6101300 GSVIVG01024100001 1061640 1065537 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01005210001 19215643 19217032 GSVIVG01034600001 14685254 14695699 GSVIVG01011114001 1458593 1473823 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01023032001 16590469 16604858 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01023032001 16590469 16604858 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01023032001 16590469 16604858 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034037001 15672038 15674377 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the removal of a phosphate group from phosphorylated myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol. IEA GO:0004437 inositol or phosphatidylinositol phosphatase activity GSVIVG01034037001 15672038 15674377 GO:0016051 carbohydrate biosynthetic process The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the removal of a phosphate group from phosphorylated myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol. IEA GO:0004437 inositol or phosphatidylinositol phosphatase activity GSVIVG01034037001 15672038 15674377 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01034037001 15672038 15674377 GO:0016051 carbohydrate biosynthetic process The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01034037001 15672038 15674377 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate. IEA GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity GSVIVG01034037001 15672038 15674377 GO:0016051 carbohydrate biosynthetic process The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate. IEA GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity GSVIVG01034037001 15672038 15674377 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3. IEA GO:0042578 phosphoric ester hydrolase activity GSVIVG01034037001 15672038 15674377 GO:0016051 carbohydrate biosynthetic process The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3. IEA GO:0042578 phosphoric ester hydrolase activity GSVIVG01011861001 3514022 3515031 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar. IEA GO:0008375 acetylglucosaminyltransferase activity GSVIVG01011406001 29390984 29392813 GSVIVG01001328001 5381924 5391817 GO:0005777 peroxisome A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2). IEA GSVIVG01034292001 14197216 14204725 GSVIVG01012079001 1589379 1597918 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: phosphatidylcholine + a sterol = a sterol ester + 1-acylglycerophosphocholine. IEA GO:0004607 phosphatidylcholine-sterol O-acyltransferase activity GSVIVG01008754001 1721216 1721614 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01008754001 1721216 1721614 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01012454001 1116485 1117703 GSVIVG01015471001 3983662 3988234 GSVIVG01021019001 15242016 15245854 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01032005001 23637905 23649421 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032005001 23637905 23649421 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01032005001 23637905 23649421 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01037073001 8185981 8188614 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01037073001 8185981 8188614 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028688001 12141632 12142270 GSVIVG01005082001 14352399 14362008 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01020567001 4237662 4238623 Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01020567001 4237662 4238623 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01038298001 12399801 12406053 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038298001 12399801 12406053 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032445001 27478390 27491475 GSVIVG01031683001 20139031 20140948 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01034484001 20616881 20617809 GSVIVG01027701001 14110225 14110401 GSVIVG01021757001 10653652 10654661 GSVIVG01023676001 8974401 8975487 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01023676001 8974401 8975487 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01023676001 8974401 8975487 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01023676001 8974401 8975487 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036645001 19671223 19740800 GSVIVG01034402001 16821812 16824079 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01034402001 16821812 16824079 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01014978001 13603258 13607510 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01014978001 13603258 13607510 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01014978001 13603258 13607510 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01014978001 13603258 13607510 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01014978001 13603258 13607510 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01014978001 13603258 13607510 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01005219001 19334050 19373321 GSVIVG01018132001 6849121 6865111 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01018132001 6849121 6865111 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01031156001 1645382 1649689 GSVIVG01017348001 7042517 7054897 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01017348001 7042517 7054897 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01017348001 7042517 7054897 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01017348001 7042517 7054897 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011005001 2279680 2285670 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01011005001 2279680 2285670 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01011005001 2279680 2285670 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01011005001 2279680 2285670 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01011005001 2279680 2285670 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01011005001 2279680 2285670 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01011005001 2279680 2285670 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01011005001 2279680 2285670 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01011005001 2279680 2285670 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01011005001 2279680 2285670 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01037078001 8035061 8039037 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004185 serine-type carboxypeptidase activity GSVIVG01012741001 1146755 1151889 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01012741001 1146755 1151889 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01012741001 1146755 1151889 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01012741001 1146755 1151889 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01008864001 2899090 2903995 GSVIVG01018791001 19816688 19817188 GSVIVG01013313001 11757139 11767614 GSVIVG01036079001 20968158 20976639 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01011152001 7369148 7372137 GSVIVG01011563001 6449551 6457538 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01027000001 18666221 18673988 GSVIVG01001089001 22567823 22570236 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01001089001 22567823 22570236 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01019293001 1791086 1795242 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019293001 1791086 1795242 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019293001 1791086 1795242 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01031740001 3980932 3983684 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031740001 3980932 3983684 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the endohydrolysis of 1,4-alpha-D-glucosidic linkages in polysaccharides containing three or more 1,4-alpha-linked D-glucose units. IEA GO:0004556 alpha-amylase activity GSVIVG01031740001 3980932 3983684 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01031740001 3980932 3983684 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01015776001 17343352 17349004 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01015776001 17343352 17349004 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01019747001 2924152 2929030 GSVIVG01033485001 20328964 20336605 GSVIVG01013431001 520378 522292 GSVIVG01018793001 19803723 19806398 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018793001 19803723 19806398 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01021970001 4929733 4947384 The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01018061001 5954823 6022326 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018061001 5954823 6022326 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018061001 5954823 6022326 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018061001 5954823 6022326 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018061001 5954823 6022326 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01018061001 5954823 6022326 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01018061001 5954823 6022326 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01018061001 5954823 6022326 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01018061001 5954823 6022326 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018061001 5954823 6022326 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018061001 5954823 6022326 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018061001 5954823 6022326 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018061001 5954823 6022326 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of calcium (Ca) ions from one side of a membrane to the other. IEA GO:0015085 calcium ion transmembrane transporter activity GSVIVG01018061001 5954823 6022326 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of calcium (Ca) ions from one side of a membrane to the other. IEA GO:0015085 calcium ion transmembrane transporter activity GSVIVG01018061001 5954823 6022326 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of calcium (Ca) ions from one side of a membrane to the other. IEA GO:0015085 calcium ion transmembrane transporter activity GSVIVG01018061001 5954823 6022326 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of calcium (Ca) ions from one side of a membrane to the other. IEA GO:0015085 calcium ion transmembrane transporter activity GSVIVG01018061001 5954823 6022326 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01018061001 5954823 6022326 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01018061001 5954823 6022326 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01018061001 5954823 6022326 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01018061001 5954823 6022326 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01018061001 5954823 6022326 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01018061001 5954823 6022326 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01018061001 5954823 6022326 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01032261001 14180973 14186973 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01032261001 14180973 14186973 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01032261001 14180973 14186973 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01032261001 14180973 14186973 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01032261001 14180973 14186973 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01032261001 14180973 14186973 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01032261001 14180973 14186973 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032261001 14180973 14186973 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022598001 5753331 5754021 GSVIVG01018168001 13673376 13674768 GO:0009664 plant-type cell wall organization A process that results in the assembly and arrangement of constituent parts of the cellulose and pectin-containing cell wall, or in the disassembly of the cellulose and pectin-containing cell wall. This process is carried out at the cellular level. An example of this process is found in Arabidopsis thaliana. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA GSVIVG01018168001 13673376 13674768 GO:0019953 sexual reproduction The regular alternation, in the life cycle of haplontic, diplontic and diplohaplontic organisms, of meiosis and fertilization which provides for the production offspring. In diplontic organisms there is a life cycle in which the products of meiosis behave directly as gametes, fusing to form a zygote from which the diploid, or sexually reproductive polyploid, adult organism will develop. In diplohaplontic organisms a haploid phase (gametophyte) exists in the life cycle between meiosis and fertilization (e.g. higher plants, many algae and Fungi); the products of meiosis are spores that develop as haploid individuals from which haploid gametes develop to form a diploid zygote; diplohaplontic organisms show an alternation of haploid and diploid generations. In haplontic organisms meiosis occurs in the zygote, giving rise to four haploid cells (e.g. many algae and protozoa), only the zygote is diploid and this may form a resistant spore, tiding organisms over hard times. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA GSVIVG01012959001 11773714 11774120 GSVIVG01021810001 7072867 7077276 GSVIVG01007938001 7338061 7342277 GSVIVG01017971001 5173997 5183773 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01017971001 5173997 5183773 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01017971001 5173997 5183773 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. IEA GO:0008483 transaminase activity GSVIVG01017971001 5173997 5183773 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. IEA GO:0008483 transaminase activity GSVIVG01017971001 5173997 5183773 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). IEA GO:0016769 transferase activity, transferring nitrogenous groups GSVIVG01017971001 5173997 5183773 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). IEA GO:0016769 transferase activity, transferring nitrogenous groups GSVIVG01017971001 5173997 5183773 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01017971001 5173997 5183773 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01018334001 10890572 10898524 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01018334001 10890572 10898524 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01018334001 10890572 10898524 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01018334001 10890572 10898524 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015795001 17521528 17523801 GSVIVG01013246001 6334169 6334784 GSVIVG01012477001 13666015 13666974 GSVIVG01009180001 5831367 5832854 GSVIVG01029921001 1504614 1506667 GSVIVG01026271001 15236493 15240475 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01023429001 12180833 12182443 GO:0008643 carbohydrate transport The directed movement of carbohydrate into, out of, within or between cells by means of some external agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0000139 Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + H+(out) = sugar(in) + H+(in). IEA GO:0005351 sugar:hydrogen symporter activity GSVIVG01023429001 12180833 12182443 GO:0008643 carbohydrate transport The directed movement of carbohydrate into, out of, within or between cells by means of some external agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + H+(out) = sugar(in) + H+(in). IEA GO:0005351 sugar:hydrogen symporter activity GSVIVG01030094001 9769109 9776415 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01004403001 38407149 38409133 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016651 oxidoreductase activity, acting on NADH or NADPH GSVIVG01006512001 42559886 42560584 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01006512001 42559886 42560584 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001162001 1162901 1165852 GSVIVG01016070001 18321970 18328205 GSVIVG01017117001 4309091 4316929 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01014407001 3436085 3441137 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01021023001 15149939 15152005 GSVIVG01014912001 11696503 11698110 GSVIVG01019866001 3982830 4016481 GO:0046907 intracellular transport The directed movement of substances within a cell. IEA GSVIVG01037000001 9101007 9101492 GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA GSVIVG01011873001 3368552 3370256 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01035933001 6089265 6096741 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule. IEA GO:0000175 3'-5'-exoribonuclease activity GSVIVG01035933001 6089265 6096741 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01024621001 8312119 8312955 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024621001 8312119 8312955 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024621001 8312119 8312955 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01024621001 8312119 8312955 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01024621001 8312119 8312955 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024621001 8312119 8312955 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024621001 8312119 8312955 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024621001 8312119 8312955 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001468001 21283106 21284897 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01001468001 21283106 21284897 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01001468001 21283106 21284897 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01012759001 23778858 23780549 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014512001 4668721 4693768 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014512001 4668721 4693768 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014512001 4668721 4693768 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014512001 4668721 4693768 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014512001 4668721 4693768 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014512001 4668721 4693768 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014512001 4668721 4693768 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014512001 4668721 4693768 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014512001 4668721 4693768 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01014512001 4668721 4693768 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01015536001 4636943 4651752 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01015536001 4636943 4651752 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01015536001 4636943 4651752 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01015536001 4636943 4651752 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01038388001 11577322 11580203 GSVIVG01007976001 7037838 7044974 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007976001 7037838 7044974 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007976001 7037838 7044974 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: D-ribulose 5-phosphate = D-xylulose 5-phosphate. IEA GO:0004750 ribulose-phosphate 3-epimerase activity GSVIVG01007976001 7037838 7044974 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: D-ribulose 5-phosphate = D-xylulose 5-phosphate. IEA GO:0004750 ribulose-phosphate 3-epimerase activity GSVIVG01007830001 8604338 8609578 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01007830001 8604338 8609578 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nucleotidyl group to a reactant. IEA GO:0016779 nucleotidyltransferase activity GSVIVG01028299001 5888649 5889997 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01028299001 5888649 5889997 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01026745001 6047056 6049752 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01026745001 6047056 6049752 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01026745001 6047056 6049752 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026745001 6047056 6049752 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001030001 20378412 20417903 GSVIVG01032671001 1624037 1638553 GSVIVG01007335001 31419234 31420246 GSVIVG01031665001 19817318 19818964 GSVIVG01009494001 8851234 8854533 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GSVIVG01003784001 12674642 12674851 GSVIVG01023442001 11854250 11855258 GSVIVG01018727001 20372151 20375416 GSVIVG01013055001 9053548 9055651 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01013055001 9053548 9055651 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01013055001 9053548 9055651 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01013055001 9053548 9055651 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01013055001 9053548 9055651 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01013055001 9053548 9055651 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01013055001 9053548 9055651 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01013055001 9053548 9055651 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01010391001 20085777 20097440 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025805001 11663960 11667267 GSVIVG01025722001 12656804 12656983 GSVIVG01028102001 3826590 3828197 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01028102001 3826590 3828197 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01028102001 3826590 3828197 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01017525001 9910565 9910951 GSVIVG01016826001 1735731 1736258 GSVIVG01018397001 9799164 9801608 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01018397001 9799164 9801608 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01018397001 9799164 9801608 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01018397001 9799164 9801608 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01010351001 19713108 19715139 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01015179001 1606694 1608453 GSVIVG01035160001 12426456 12427778 GSVIVG01006478001 26335013 26356192 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01006478001 26335013 26356192 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01006478001 26335013 26356192 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01006478001 26335013 26356192 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01006478001 26335013 26356192 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01006478001 26335013 26356192 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01006478001 26335013 26356192 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01006478001 26335013 26356192 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01006478001 26335013 26356192 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006478001 26335013 26356192 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006478001 26335013 26356192 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01006478001 26335013 26356192 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01003083001 8484626 8490358 GSVIVG01020960001 16318657 16319751 GSVIVG01027776001 7611470 7613480 GSVIVG01037606001 9815632 9817635 GSVIVG01025624001 13498540 13510103 GSVIVG01006806001 28708587 28710607 GSVIVG01018138001 6960755 6966891 GSVIVG01033805001 17631311 17646496 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0005669 transcription factor TFIID complex A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01033805001 17631311 17646496 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0005669 transcription factor TFIID complex A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters. IEA IEA GO:0016986 transcription initiation factor activity GSVIVG01005044001 17649625 17669426 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01005044001 17649625 17669426 Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01017416001 8221274 8231099 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018588001 12719703 12720230 Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01018588001 12719703 12720230 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018588001 12719703 12720230 Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01018588001 12719703 12720230 Interacting selectively and non-covalently with thiamin pyrophosphate, the diphosphoric ester of thiamin. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases. IEA GO:0030976 thiamin pyrophosphate binding GSVIVG01027195001 17129507 17134086 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027195001 17129507 17134086 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027195001 17129507 17134086 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027195001 17129507 17134086 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027195001 17129507 17134086 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027195001 17129507 17134086 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027195001 17129507 17134086 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027195001 17129507 17134086 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027195001 17129507 17134086 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01027195001 17129507 17134086 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01027195001 17129507 17134086 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01027195001 17129507 17134086 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01027195001 17129507 17134086 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01027195001 17129507 17134086 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01027195001 17129507 17134086 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01027195001 17129507 17134086 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01027195001 17129507 17134086 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027195001 17129507 17134086 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027195001 17129507 17134086 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027195001 17129507 17134086 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027195001 17129507 17134086 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027195001 17129507 17134086 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027195001 17129507 17134086 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027195001 17129507 17134086 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027195001 17129507 17134086 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01027195001 17129507 17134086 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01027195001 17129507 17134086 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01027195001 17129507 17134086 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01027195001 17129507 17134086 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01027195001 17129507 17134086 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01027195001 17129507 17134086 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01027195001 17129507 17134086 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01027195001 17129507 17134086 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01027195001 17129507 17134086 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01027195001 17129507 17134086 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01027195001 17129507 17134086 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01027195001 17129507 17134086 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01027195001 17129507 17134086 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01027195001 17129507 17134086 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01027195001 17129507 17134086 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01000863001 3172318 3172473 GSVIVG01035228001 10836816 10849302 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035228001 10836816 10849302 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01003228001 14246016 14249230 GO:0042546 cell wall biogenesis The process by which a cell wall is synthesized, aggregates, and bonds together. Includes biosynthesis of constituent macromolecules, such as proteins and polysaccharides, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component. A cell wall is the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: GDP-L-fucose + beta-D-galactosyl-R = GDP + alpha-L-fucosyl-(1,2)-beta-D-galactosyl-R. IEA GO:0008107 galactoside 2-alpha-L-fucosyltransferase activity GSVIVG01037948001 11406806 11422896 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01037948001 11406806 11422896 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01037948001 11406806 11422896 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01037948001 11406806 11422896 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01037948001 11406806 11422896 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01037948001 11406806 11422896 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01037948001 11406806 11422896 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01037948001 11406806 11422896 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01016540001 2985997 2987121 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0008076 voltage-gated potassium channel complex A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01027988001 3019393 3024452 GSVIVG01026451001 23401809 23409813 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01007188001 39922 40947 GSVIVG01031120001 1980100 1985532 GSVIVG01017331001 6780762 6782814 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01017331001 6780762 6782814 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01017331001 6780762 6782814 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01017331001 6780762 6782814 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01017331001 6780762 6782814 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01017331001 6780762 6782814 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01017331001 6780762 6782814 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01017331001 6780762 6782814 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01017331001 6780762 6782814 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01017331001 6780762 6782814 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01002937001 37242213 37248557 GSVIVG01018219001 13098997 13100695 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018219001 13098997 13100695 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018219001 13098997 13100695 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018219001 13098997 13100695 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01018219001 13098997 13100695 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01018219001 13098997 13100695 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01018219001 13098997 13100695 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01018219001 13098997 13100695 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01018219001 13098997 13100695 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01018219001 13098997 13100695 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01018219001 13098997 13100695 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01018219001 13098997 13100695 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01036113001 20551502 20558152 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01036113001 20551502 20558152 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01036113001 20551502 20558152 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036113001 20551502 20558152 Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01029559001 21569331 21569744 GSVIVG01020600001 3932276 3940031 GSVIVG01013130001 7879596 7885136 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01013130001 7879596 7885136 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01035047001 1148995 1153335 GO:0006606 protein import into nucleus The directed movement of a protein from the cytoplasm to the nucleus. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035047001 1148995 1153335 GO:0006606 protein import into nucleus The directed movement of a protein from the cytoplasm to the nucleus. IEA GO:0005643 nuclear pore Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035047001 1148995 1153335 GO:0006606 protein import into nucleus The directed movement of a protein from the cytoplasm to the nucleus. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035047001 1148995 1153335 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035047001 1148995 1153335 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005643 nuclear pore Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035047001 1148995 1153335 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035047001 1148995 1153335 GO:0006606 protein import into nucleus The directed movement of a protein from the cytoplasm to the nucleus. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01035047001 1148995 1153335 GO:0006606 protein import into nucleus The directed movement of a protein from the cytoplasm to the nucleus. IEA GO:0005643 nuclear pore Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01035047001 1148995 1153335 GO:0006606 protein import into nucleus The directed movement of a protein from the cytoplasm to the nucleus. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01035047001 1148995 1153335 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01035047001 1148995 1153335 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005643 nuclear pore Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01035047001 1148995 1153335 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01036981001 9296798 9310939 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01036981001 9296798 9310939 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). IEA GO:0016769 transferase activity, transferring nitrogenous groups GSVIVG01036981001 9296798 9310939 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01035576001 2431147 2462039 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01035576001 2431147 2462039 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01035576001 2431147 2462039 GO:0006268 DNA unwinding involved in replication The process by which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01035576001 2431147 2462039 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035576001 2431147 2462039 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035576001 2431147 2462039 GO:0006268 DNA unwinding involved in replication The process by which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035576001 2431147 2462039 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA. IEA GO:0003916 DNA topoisomerase activity GSVIVG01035576001 2431147 2462039 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA. IEA GO:0003916 DNA topoisomerase activity GSVIVG01035576001 2431147 2462039 GO:0006268 DNA unwinding involved in replication The process by which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA. IEA GO:0003916 DNA topoisomerase activity GSVIVG01035576001 2431147 2462039 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle. IEA GO:0003917 DNA topoisomerase type I activity GSVIVG01035576001 2431147 2462039 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle. IEA GO:0003917 DNA topoisomerase type I activity GSVIVG01035576001 2431147 2462039 GO:0006268 DNA unwinding involved in replication The process by which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle. IEA GO:0003917 DNA topoisomerase type I activity GSVIVG01037673001 6729221 6732091 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01037673001 6729221 6732091 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01033847001 17271769 17277861 GO:0000105 histidine biosynthetic process The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033847001 17271769 17277861 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033847001 17271769 17277861 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033847001 17271769 17277861 GO:0000105 histidine biosynthetic process The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. IEA Catalysis of the reaction: N-(5'-phospho-D-ribosylformimino)-5-amino-1-(5''-phosphoribosyl)-4-imidazolecarboxamide = N-(5'-phospho-D-1'-ribulosylformimino)-5-amino-1-(5''-phosphoribosyl)-4-imidazolecarboxamide. IEA GO:0003949 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity GSVIVG01033847001 17271769 17277861 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: N-(5'-phospho-D-ribosylformimino)-5-amino-1-(5''-phosphoribosyl)-4-imidazolecarboxamide = N-(5'-phospho-D-1'-ribulosylformimino)-5-amino-1-(5''-phosphoribosyl)-4-imidazolecarboxamide. IEA GO:0003949 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity GSVIVG01033847001 17271769 17277861 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the reaction: N-(5'-phospho-D-ribosylformimino)-5-amino-1-(5''-phosphoribosyl)-4-imidazolecarboxamide = N-(5'-phospho-D-1'-ribulosylformimino)-5-amino-1-(5''-phosphoribosyl)-4-imidazolecarboxamide. IEA GO:0003949 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity GSVIVG01031460001 18292025 18298216 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01031460001 18292025 18298216 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01002065001 1293738 1298924 GSVIVG01012794001 23183211 23184495 GSVIVG01026446001 23569495 23589672 GSVIVG01023155001 21829578 21859608 Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01023155001 21829578 21859608 Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01024634001 8172873 8203228 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024634001 8172873 8203228 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024634001 8172873 8203228 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01024634001 8172873 8203228 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01024634001 8172873 8203228 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01024634001 8172873 8203228 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01024634001 8172873 8203228 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024634001 8172873 8203228 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024634001 8172873 8203228 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01024634001 8172873 8203228 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01016589001 2583730 2599209 GSVIVG01038778001 825003 827222 GO:0006481 C-terminal protein amino acid methylation The methylation of the C-terminal amino acid of a protein. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester. IEA GO:0004671 protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity GSVIVG01037437001 13746022 13765300 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01037437001 13746022 13765300 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01037437001 13746022 13765300 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037437001 13746022 13765300 Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01037437001 13746022 13765300 Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. IEA GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GSVIVG01025460001 674989 687565 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01012605001 4547946 4553936 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012605001 4547946 4553936 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01012605001 4547946 4553936 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01010034001 13676034 13681500 GSVIVG01021645001 8641580 8672887 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01021645001 8641580 8672887 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01021645001 8641580 8672887 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01021645001 8641580 8672887 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01021645001 8641580 8672887 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029481001 22368874 22376102 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028988001 10143147 10149603 GSVIVG01021087001 1346397 1348752 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01036707001 23508849 23538511 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036707001 23508849 23538511 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01019450001 775165 779587 GSVIVG01002864001 36898343 36902486 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01002864001 36898343 36902486 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01002864001 36898343 36902486 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01002864001 36898343 36902486 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033312001 21606186 21606527 GSVIVG01016489001 3455784 3459135 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016489001 3455784 3459135 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016489001 3455784 3459135 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016489001 3455784 3459135 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01016489001 3455784 3459135 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01016489001 3455784 3459135 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01016489001 3455784 3459135 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016489001 3455784 3459135 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016489001 3455784 3459135 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016489001 3455784 3459135 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01016489001 3455784 3459135 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01016489001 3455784 3459135 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01016489001 3455784 3459135 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016489001 3455784 3459135 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016489001 3455784 3459135 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01017290001 6420435 6421452 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01017290001 6420435 6421452 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01017290001 6420435 6421452 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01017290001 6420435 6421452 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01016019001 17414496 17430530 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016240001 6030373 6044405 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016240001 6030373 6044405 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016240001 6030373 6044405 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01016240001 6030373 6044405 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01027823001 8186956 8196949 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01027823001 8186956 8196949 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008021001 6613320 6614938 GSVIVG01007583001 11642834 11645637 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function that links a sequence-specific transcription factor to the core RNA polymerase II complex but does not bind DNA itself. IEA GO:0003712 transcription cofactor activity GSVIVG01007583001 11642834 11645637 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone. IEA GO:0004402 histone acetyltransferase activity GSVIVG01007583001 11642834 11645637 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01007583001 11642834 11645637 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01009033001 4433241 4440087 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the repair of a photoproduct resulting from ultraviolet irradiation of two adjacent pyrimidine residues in DNA. IEA GO:0003913 DNA photolyase activity GSVIVG01027848001 8606637 8607245 GSVIVG01028124001 4010241 4015186 GSVIVG01037240001 16989875 16994238 GSVIVG01022628001 13744082 13747505 GSVIVG01033653001 18908144 18916524 GO:0006777 Mo-molybdopterin cofactor biosynthetic process The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01033653001 18908144 18916524 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01012625001 177396 180511 GSVIVG01011955001 2666172 2676092 GSVIVG01009198001 6060381 6094675 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01009198001 6060381 6094675 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01009198001 6060381 6094675 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01037707001 7124168 7133937 GSVIVG01009321001 7423439 7432402 GSVIVG01005313001 20620339 20620723 GSVIVG01031086001 2484993 2493423 GO:0006413 translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. IEA Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. IEA GO:0003743 translation initiation factor activity GSVIVG01031086001 2484993 2493423 GO:0006413 translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013777001 7694293 7695534 GSVIVG01024910001 6106645 6109419 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027639001 14772969 14778146 GSVIVG01016797001 1475993 1477697 GSVIVG01030618001 7212553 7212769 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA GSVIVG01030618001 7212553 7212769 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009522 photosystem I A photosystem that contains an iron-sulfur reaction center associated with accessory pigments and electron carriers. In cyanobacteria and chloroplasts, photosystem I functions as a light-dependent plastocyanin-ferredoxin oxidoreductase, transferring electrons from plastocyanin to ferredoxin; in photosynthetic bacteria that have only a single type I photosystem, such as the green sulfur bacteria, electrons can go either to ferredoxin (Fd) -> NAD+ or to menaquinone (MK) -> Cytb/FeS -> Cytc555 -> photosystem I (cyclic photophosphorylation). IEA GSVIVG01030618001 7212553 7212769 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009535 chloroplast thylakoid membrane The pigmented membrane of a chloroplast thylakoid. An example of this component is found in Arabidopsis thaliana. IEA GSVIVG01030618001 7212553 7212769 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA GSVIVG01030618001 7212553 7212769 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009579 thylakoid A membranous cellular structure that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the plasma membrane. In eukaryotes they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation. IEA GSVIVG01030618001 7212553 7212769 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01030618001 7212553 7212769 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01034471001 20804952 20805962 GSVIVG01021619001 8228165 8231198 GSVIVG01031921001 5419479 5421579 GSVIVG01016874001 2161223 2163097 GSVIVG01025058001 4881432 4881813 GSVIVG01013081001 8613300 8613605 GSVIVG01038340001 13258745 13259919 GO:0008654 phospholipid biosynthetic process The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester. IEA Catalysis of the reaction: phosphatidyl-L-serine = phosphatidylethanolamine + CO2. IEA GO:0004609 phosphatidylserine decarboxylase activity GSVIVG01028440001 7535201 7546064 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01028440001 7535201 7546064 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01028440001 7535201 7546064 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028440001 7535201 7546064 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028440001 7535201 7546064 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01028440001 7535201 7546064 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01028440001 7535201 7546064 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01028440001 7535201 7546064 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01028440001 7535201 7546064 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01028440001 7535201 7546064 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01022494001 3857626 3904727 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01022494001 3857626 3904727 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01037330001 15577642 15582554 GSVIVG01008858001 2866301 2870837 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01008858001 2866301 2870837 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01008858001 2866301 2870837 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and carries out proton transport across a membrane. The proton-transporting domain (F0, V0, or A0) includes integral and peripheral membrane proteins. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01008858001 2866301 2870837 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0033179 proton-transporting V-type ATPase, V0 domain A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01008858001 2866301 2870837 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01008858001 2866301 2870837 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01008858001 2866301 2870837 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and carries out proton transport across a membrane. The proton-transporting domain (F0, V0, or A0) includes integral and peripheral membrane proteins. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01008858001 2866301 2870837 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033179 proton-transporting V-type ATPase, V0 domain A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01008858001 2866301 2870837 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01008858001 2866301 2870837 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01008858001 2866301 2870837 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and carries out proton transport across a membrane. The proton-transporting domain (F0, V0, or A0) includes integral and peripheral membrane proteins. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01008858001 2866301 2870837 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033179 proton-transporting V-type ATPase, V0 domain A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01008858001 2866301 2870837 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01008858001 2866301 2870837 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01008858001 2866301 2870837 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and carries out proton transport across a membrane. The proton-transporting domain (F0, V0, or A0) includes integral and peripheral membrane proteins. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01008858001 2866301 2870837 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033179 proton-transporting V-type ATPase, V0 domain A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01036527001 23073872 23082769 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01036527001 23073872 23082769 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01036527001 23073872 23082769 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01036527001 23073872 23082769 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011392001 29291522 29294252 GSVIVG01020325001 21321945 21330018 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020325001 21321945 21330018 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020325001 21321945 21330018 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020325001 21321945 21330018 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007632001 11017886 11022885 GSVIVG01010209001 17503356 17552700 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031255001 752322 764335 GSVIVG01021556001 7040621 7046005 Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01032888001 23804742 23821929 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01032888001 23804742 23821929 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01032888001 23804742 23821929 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01032888001 23804742 23821929 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016181001 7007915 7010096 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016181001 7007915 7010096 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01016181001 7007915 7010096 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01016181001 7007915 7010096 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008649001 108833 110748 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01008649001 108833 110748 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01035740001 3830985 3835172 GSVIVG01009754001 10999096 11003121 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01004722001 15514618 15523941 GO:0006189 'de novo' IMP biosynthetic process The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate. IEA Catalysis of the reaction: 10-formyltetrahydrofolate + H2O = formate + tetrahydrofolate. IEA GO:0008864 formyltetrahydrofolate deformylase activity GSVIVG01004722001 15514618 15523941 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: 10-formyltetrahydrofolate + H2O = formate + tetrahydrofolate. IEA GO:0008864 formyltetrahydrofolate deformylase activity GSVIVG01004722001 15514618 15523941 GO:0006189 'de novo' IMP biosynthetic process The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate. IEA IEA GO:0016742 hydroxymethyl-, formyl- and related transferase activity GSVIVG01004722001 15514618 15523941 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA IEA GO:0016742 hydroxymethyl-, formyl- and related transferase activity GSVIVG01026774001 6848585 6940548 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026774001 6848585 6940548 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01026774001 6848585 6940548 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nucleotidyl group to a reactant. IEA GO:0016779 nucleotidyltransferase activity GSVIVG01007635001 11011843 11013532 GSVIVG01030297001 9322655 9332545 GSVIVG01016693001 413674 425713 GSVIVG01018022001 5545191 5549019 GSVIVG01019647001 2182864 2194766 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01038175001 24075041 24080837 GO:0006631 fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01038175001 24075041 24080837 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01038175001 24075041 24080837 GO:0006631 fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. IEA Catalysis of the reaction: stearoyl-[acyl-carrier protein] + reduced acceptor + O2 = oleoyl-[acyl-carrier protein] + acceptor + H2O. The enzyme requires ferredoxin. IEA GO:0045300 acyl-[acyl-carrier-protein] desaturase activity GSVIVG01038175001 24075041 24080837 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: stearoyl-[acyl-carrier protein] + reduced acceptor + O2 = oleoyl-[acyl-carrier protein] + acceptor + H2O. The enzyme requires ferredoxin. IEA GO:0045300 acyl-[acyl-carrier-protein] desaturase activity GSVIVG01038175001 24075041 24080837 GO:0006631 fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01038175001 24075041 24080837 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01028862001 18021206 18021998 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01001086001 22510170 22524870 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01001086001 22510170 22524870 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01037188001 28184067 28198137 GSVIVG01015431001 3605955 3611360 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01015521001 4424880 4427726 GSVIVG01012808001 5586712 5591626 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01035947001 6284453 6286825 GO:0001503 ossification The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance. IEA GSVIVG01035947001 6284453 6286825 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GSVIVG01015263001 2179492 2187051 GSVIVG01025504001 260301 263555 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01025504001 260301 263555 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025504001 260301 263555 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the reaction: ATP + pyruvate = ADP + phosphoenolpyruvate. IEA GO:0004743 pyruvate kinase activity GSVIVG01025504001 260301 263555 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Interacting selectively and non-covalently with potassium (K+) ions. IEA GO:0030955 potassium ion binding GSVIVG01000303001 2736691 2737613 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01000303001 2736691 2737613 Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium. IEA GO:0005544 calcium-dependent phospholipid binding GSVIVG01013272001 5804013 5807077 GO:0000272 polysaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01013272001 5804013 5807077 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01013272001 5804013 5807077 GO:0000272 polysaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages. IEA Catalysis of the hydrolysis of 1,4-alpha-glucosidic linkages in polysaccharides so as to remove successive maltose units from the non-reducing ends of the chains. IEA GO:0016161 beta-amylase activity GSVIVG01013272001 5804013 5807077 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of 1,4-alpha-glucosidic linkages in polysaccharides so as to remove successive maltose units from the non-reducing ends of the chains. IEA GO:0016161 beta-amylase activity GSVIVG01013272001 5804013 5807077 GO:0000272 polysaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01013272001 5804013 5807077 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01002818001 36743452 36749796 GO:0032313 regulation of Rab GTPase activity Any process that modulates the activity of a GTPase of the Rab family. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Increases the rate of GTP hydrolysis by a GTPase of the Rab family. IEA GO:0005097 Rab GTPase activator activity GSVIVG01031201001 1219882 1227099 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion. IEA GO:0005484 SNAP receptor activity GSVIVG01031201001 1219882 1227099 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion. IEA GO:0005484 SNAP receptor activity GSVIVG01031201001 1219882 1227099 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031201001 1219882 1227099 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01019561001 1624199 1627954 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019561001 1624199 1627954 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of a transcription cofactor that activates transcription from a RNA polymerase II promoter; does not bind DNA itself. IEA GO:0003713 transcription coactivator activity GSVIVG01019561001 1624199 1627954 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027913001 9330147 9331928 GSVIVG01007768001 9253868 9254795 GSVIVG01032714001 1310001 1311298 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01037083001 29341758 29342811 GSVIVG01025077001 4744304 4747169 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01025077001 4744304 4747169 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01025077001 4744304 4747169 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01025077001 4744304 4747169 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01025077001 4744304 4747169 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025077001 4744304 4747169 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025077001 4744304 4747169 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01025077001 4744304 4747169 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01015121001 1183302 1191026 GSVIVG01028565001 9926246 9934777 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01027679001 14411453 14418228 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation Splicing of tRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01032268001 14289240 14297403 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01029817001 15291192 15291688 GSVIVG01025783001 11900431 11919397 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025783001 11900431 11919397 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025783001 11900431 11919397 Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01025783001 11900431 11919397 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01009258001 6747126 6750253 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01009258001 6747126 6750253 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01009258001 6747126 6750253 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01009258001 6747126 6750253 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01009258001 6747126 6750253 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01009258001 6747126 6750253 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01009258001 6747126 6750253 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01009258001 6747126 6750253 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01009258001 6747126 6750253 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01009258001 6747126 6750253 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01009258001 6747126 6750253 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01009258001 6747126 6750253 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01009258001 6747126 6750253 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01009258001 6747126 6750253 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01009258001 6747126 6750253 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01009258001 6747126 6750253 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01009258001 6747126 6750253 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01009258001 6747126 6750253 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01009258001 6747126 6750253 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01009258001 6747126 6750253 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01009258001 6747126 6750253 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01009258001 6747126 6750253 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01009258001 6747126 6750253 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01009258001 6747126 6750253 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01009258001 6747126 6750253 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01009258001 6747126 6750253 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01009258001 6747126 6750253 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01013427001 535475 538079 GSVIVG01033225001 9991454 10005125 GSVIVG01026461001 23170212 23225736 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01026461001 23170212 23225736 GO:0006268 DNA unwinding involved in replication The process by which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01026461001 23170212 23225736 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01026461001 23170212 23225736 GO:0006268 DNA unwinding involved in replication The process by which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01026461001 23170212 23225736 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA. IEA GO:0003916 DNA topoisomerase activity GSVIVG01026461001 23170212 23225736 GO:0006268 DNA unwinding involved in replication The process by which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA. IEA GO:0003916 DNA topoisomerase activity GSVIVG01026461001 23170212 23225736 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle. IEA GO:0003917 DNA topoisomerase type I activity GSVIVG01026461001 23170212 23225736 GO:0006268 DNA unwinding involved in replication The process by which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle. IEA GO:0003917 DNA topoisomerase type I activity GSVIVG01026461001 23170212 23225736 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01026461001 23170212 23225736 GO:0006268 DNA unwinding involved in replication The process by which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01009891001 12160376 12174229 GO:0006413 translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. IEA Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. IEA GO:0003743 translation initiation factor activity GSVIVG01014388001 3298278 3300519 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01014388001 3298278 3300519 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01014388001 3298278 3300519 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01014388001 3298278 3300519 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01014388001 3298278 3300519 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01014388001 3298278 3300519 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01014388001 3298278 3300519 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01014388001 3298278 3300519 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01014388001 3298278 3300519 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01014388001 3298278 3300519 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01014388001 3298278 3300519 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01014388001 3298278 3300519 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01014388001 3298278 3300519 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: chlorophyllide A + NADP+ = protochlorophyllide + NADPH + H+. IEA GO:0016630 protochlorophyllide reductase activity GSVIVG01014388001 3298278 3300519 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: chlorophyllide A + NADP+ = protochlorophyllide + NADPH + H+. IEA GO:0016630 protochlorophyllide reductase activity GSVIVG01014388001 3298278 3300519 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: chlorophyllide A + NADP+ = protochlorophyllide + NADPH + H+. IEA GO:0016630 protochlorophyllide reductase activity GSVIVG01013858001 5407591 5417952 GSVIVG01014402001 3404282 3407783 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01014402001 3404282 3407783 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01014402001 3404282 3407783 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01014402001 3404282 3407783 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014402001 3404282 3407783 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01014402001 3404282 3407783 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01018629001 11999043 12003260 GSVIVG01035648001 2974863 2984519 GSVIVG01028063001 3538632 3549120 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01028063001 3538632 3549120 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01028063001 3538632 3549120 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01028063001 3538632 3549120 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01028063001 3538632 3549120 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01028063001 3538632 3549120 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01028063001 3538632 3549120 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01028063001 3538632 3549120 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01028063001 3538632 3549120 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01028063001 3538632 3549120 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01028063001 3538632 3549120 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01028063001 3538632 3549120 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01028063001 3538632 3549120 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028063001 3538632 3549120 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028063001 3538632 3549120 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028063001 3538632 3549120 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028063001 3538632 3549120 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028063001 3538632 3549120 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028063001 3538632 3549120 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028063001 3538632 3549120 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028063001 3538632 3549120 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028063001 3538632 3549120 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028063001 3538632 3549120 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028063001 3538632 3549120 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008760001 1761929 1765473 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01008760001 1761929 1765473 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01008760001 1761929 1765473 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008760001 1761929 1765473 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01012189001 697863 701409 GSVIVG01015035001 629189 640325 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01015035001 629189 640325 GO:0009725 response to hormone stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01015035001 629189 640325 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01015035001 629189 640325 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01015035001 629189 640325 GO:0009725 response to hormone stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01015035001 629189 640325 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01006000001 24349999 24352648 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01006000001 24349999 24352648 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01006000001 24349999 24352648 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. IEA GO:0004563 beta-N-acetylhexosaminidase activity GSVIVG01006000001 24349999 24352648 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01035624001 2777825 2778904 GO:0006954 inflammatory response The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with the interleukin-1 receptor. IEA GO:0005149 interleukin-1 receptor binding GSVIVG01035624001 2777825 2778904 GO:0006955 immune response Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with the interleukin-1 receptor. IEA GO:0005149 interleukin-1 receptor binding GSVIVG01027651001 14636233 14639040 GSVIVG01003346001 9200931 9231333 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003346001 9200931 9231333 GO:0009072 aromatic amino acid family metabolic process The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003346001 9200931 9231333 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 4-fumarylacetoacetate + H2O = acetoacetate + fumarate. IEA GO:0004334 fumarylacetoacetase activity GSVIVG01003346001 9200931 9231333 GO:0009072 aromatic amino acid family metabolic process The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). IEA Catalysis of the reaction: 4-fumarylacetoacetate + H2O = acetoacetate + fumarate. IEA GO:0004334 fumarylacetoacetase activity GSVIVG01005093001 14481846 14486193 GSVIVG01000735001 287541 292979 GSVIVG01031343001 224731 227163 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01016717001 584154 604487 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005643 nuclear pore Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined. IEA GSVIVG01033677001 18763853 18764915 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01000658001 20496394 20507160 GO:0006955 immune response Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01000658001 20496394 20507160 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01017261001 6039189 6040954 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01017261001 6039189 6040954 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01017261001 6039189 6040954 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01017261001 6039189 6040954 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01017261001 6039189 6040954 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01017261001 6039189 6040954 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01017261001 6039189 6040954 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01017261001 6039189 6040954 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01017261001 6039189 6040954 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017261001 6039189 6040954 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017261001 6039189 6040954 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017261001 6039189 6040954 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006805001 28706309 28708580 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin. IEA GO:0004748 ribonucleoside-diphosphate reductase activity GSVIVG01006805001 28706309 28708580 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin. IEA GO:0004748 ribonucleoside-diphosphate reductase activity GSVIVG01006805001 28706309 28708580 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin. IEA GO:0004748 ribonucleoside-diphosphate reductase activity GSVIVG01006805001 28706309 28708580 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin. IEA GO:0004748 ribonucleoside-diphosphate reductase activity GSVIVG01006805001 28706309 28708580 GO:0009186 deoxyribonucleoside diphosphate metabolic process The chemical reactions and pathways involving a deoxyribonucleoside diphosphate, a glycosamine consisting of a base linked to a deoxyribose sugar esterified with diphosphate on its glycose moiety. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin. IEA GO:0004748 ribonucleoside-diphosphate reductase activity GSVIVG01006805001 28706309 28708580 GO:0009186 deoxyribonucleoside diphosphate metabolic process The chemical reactions and pathways involving a deoxyribonucleoside diphosphate, a glycosamine consisting of a base linked to a deoxyribose sugar esterified with diphosphate on its glycose moiety. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin. IEA GO:0004748 ribonucleoside-diphosphate reductase activity GSVIVG01006805001 28706309 28708580 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin. IEA GO:0004748 ribonucleoside-diphosphate reductase activity GSVIVG01006805001 28706309 28708580 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin. IEA GO:0004748 ribonucleoside-diphosphate reductase activity GSVIVG01006805001 28706309 28708580 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin. IEA GO:0004748 ribonucleoside-diphosphate reductase activity GSVIVG01006805001 28706309 28708580 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin. IEA GO:0004748 ribonucleoside-diphosphate reductase activity GSVIVG01006805001 28706309 28708580 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01006805001 28706309 28708580 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01006805001 28706309 28708580 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01006805001 28706309 28708580 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01006805001 28706309 28708580 GO:0009186 deoxyribonucleoside diphosphate metabolic process The chemical reactions and pathways involving a deoxyribonucleoside diphosphate, a glycosamine consisting of a base linked to a deoxyribose sugar esterified with diphosphate on its glycose moiety. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01006805001 28706309 28708580 GO:0009186 deoxyribonucleoside diphosphate metabolic process The chemical reactions and pathways involving a deoxyribonucleoside diphosphate, a glycosamine consisting of a base linked to a deoxyribose sugar esterified with diphosphate on its glycose moiety. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01006805001 28706309 28708580 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01006805001 28706309 28708580 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01006805001 28706309 28708580 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01006805001 28706309 28708580 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01006805001 28706309 28708580 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01006805001 28706309 28708580 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01006805001 28706309 28708580 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01006805001 28706309 28708580 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01006805001 28706309 28708580 GO:0009186 deoxyribonucleoside diphosphate metabolic process The chemical reactions and pathways involving a deoxyribonucleoside diphosphate, a glycosamine consisting of a base linked to a deoxyribose sugar esterified with diphosphate on its glycose moiety. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01006805001 28706309 28708580 GO:0009186 deoxyribonucleoside diphosphate metabolic process The chemical reactions and pathways involving a deoxyribonucleoside diphosphate, a glycosamine consisting of a base linked to a deoxyribose sugar esterified with diphosphate on its glycose moiety. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01006805001 28706309 28708580 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01006805001 28706309 28708580 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01006805001 28706309 28708580 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01006805001 28706309 28708580 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01006805001 28706309 28708580 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01006805001 28706309 28708580 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01006805001 28706309 28708580 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01006805001 28706309 28708580 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01006805001 28706309 28708580 GO:0009186 deoxyribonucleoside diphosphate metabolic process The chemical reactions and pathways involving a deoxyribonucleoside diphosphate, a glycosamine consisting of a base linked to a deoxyribose sugar esterified with diphosphate on its glycose moiety. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01006805001 28706309 28708580 GO:0009186 deoxyribonucleoside diphosphate metabolic process The chemical reactions and pathways involving a deoxyribonucleoside diphosphate, a glycosamine consisting of a base linked to a deoxyribose sugar esterified with diphosphate on its glycose moiety. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01006805001 28706309 28708580 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01006805001 28706309 28708580 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01006805001 28706309 28708580 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01006805001 28706309 28708580 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01006805001 28706309 28708580 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01006805001 28706309 28708580 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01006805001 28706309 28708580 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01006805001 28706309 28708580 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01006805001 28706309 28708580 GO:0009186 deoxyribonucleoside diphosphate metabolic process The chemical reactions and pathways involving a deoxyribonucleoside diphosphate, a glycosamine consisting of a base linked to a deoxyribose sugar esterified with diphosphate on its glycose moiety. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01006805001 28706309 28708580 GO:0009186 deoxyribonucleoside diphosphate metabolic process The chemical reactions and pathways involving a deoxyribonucleoside diphosphate, a glycosamine consisting of a base linked to a deoxyribose sugar esterified with diphosphate on its glycose moiety. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01006805001 28706309 28708580 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01006805001 28706309 28708580 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01006805001 28706309 28708580 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01006805001 28706309 28708580 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01006805001 28706309 28708580 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01006805001 28706309 28708580 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01006805001 28706309 28708580 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01006805001 28706309 28708580 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01006805001 28706309 28708580 GO:0009186 deoxyribonucleoside diphosphate metabolic process The chemical reactions and pathways involving a deoxyribonucleoside diphosphate, a glycosamine consisting of a base linked to a deoxyribose sugar esterified with diphosphate on its glycose moiety. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01006805001 28706309 28708580 GO:0009186 deoxyribonucleoside diphosphate metabolic process The chemical reactions and pathways involving a deoxyribonucleoside diphosphate, a glycosamine consisting of a base linked to a deoxyribose sugar esterified with diphosphate on its glycose moiety. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01006805001 28706309 28708580 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01006805001 28706309 28708580 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01006805001 28706309 28708580 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01006805001 28706309 28708580 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01034428001 16398365 16403107 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01034428001 16398365 16403107 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01034428001 16398365 16403107 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01034428001 16398365 16403107 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01034428001 16398365 16403107 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034428001 16398365 16403107 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034428001 16398365 16403107 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01034428001 16398365 16403107 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01022662001 14288038 14289093 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01014697001 8734445 8743698 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033134001 8216408 8218144 GSVIVG01010973001 2512698 2513559 GSVIVG01005245001 19815043 19815702 GSVIVG01000582001 6869577 6871249 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004197 cysteine-type endopeptidase activity GSVIVG01000582001 6869577 6871249 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01028004001 3120742 3129795 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028004001 3120742 3129795 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01028004001 3120742 3129795 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01025151001 3941998 3962604 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01025151001 3941998 3962604 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025151001 3941998 3962604 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01009713001 10686781 10698400 GSVIVG01009350001 7611417 7618197 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009350001 7611417 7618197 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009350001 7611417 7618197 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01009350001 7611417 7618197 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01009350001 7611417 7618197 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01009350001 7611417 7618197 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01014972001 13282082 13301096 GSVIVG01015512001 4345817 4350218 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033274001 21955659 21956704 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01033274001 21955659 21956704 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01033274001 21955659 21956704 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01033274001 21955659 21956704 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028371001 6757378 6760531 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01028371001 6757378 6760531 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GSVIVG01028371001 6757378 6760531 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01023604001 7893301 7904813 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain. IEA GO:0004177 aminopeptidase activity GSVIVG01023604001 7893301 7904813 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain. IEA GO:0004177 aminopeptidase activity GSVIVG01023604001 7893301 7904813 GO:0019538 protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain. IEA GO:0004177 aminopeptidase activity GSVIVG01023604001 7893301 7904813 GO:0019538 protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain. IEA GO:0004177 aminopeptidase activity GSVIVG01023604001 7893301 7904813 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008235 metalloexopeptidase activity GSVIVG01023604001 7893301 7904813 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008235 metalloexopeptidase activity GSVIVG01023604001 7893301 7904813 GO:0019538 protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008235 metalloexopeptidase activity GSVIVG01023604001 7893301 7904813 GO:0019538 protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008235 metalloexopeptidase activity GSVIVG01023604001 7893301 7904813 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with manganese (Mn) ions. IEA GO:0030145 manganese ion binding GSVIVG01023604001 7893301 7904813 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with manganese (Mn) ions. IEA GO:0030145 manganese ion binding GSVIVG01023604001 7893301 7904813 GO:0019538 protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with manganese (Mn) ions. IEA GO:0030145 manganese ion binding GSVIVG01023604001 7893301 7904813 GO:0019538 protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with manganese (Mn) ions. IEA GO:0030145 manganese ion binding GSVIVG01032129001 22378711 22382878 GSVIVG01030871001 18143334 18154741 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01030871001 18143334 18154741 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01030871001 18143334 18154741 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01030871001 18143334 18154741 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01009706001 10650839 10656771 GSVIVG01022712001 15448344 15450510 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. IEA GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GSVIVG01034930001 188849 198725 GSVIVG01017677001 2561355 2563987 GSVIVG01016039001 17758712 17766637 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01016039001 17758712 17766637 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01016039001 17758712 17766637 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01016039001 17758712 17766637 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016039001 17758712 17766637 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016055001 18105560 18107467 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016055001 18105560 18107467 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01001314001 5245992 5247909 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01037811001 7652632 7661288 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01037811001 7652632 7661288 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01021271001 3253499 3259640 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01037015001 8895286 8912074 GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA GSVIVG01035433001 1237845 1238388 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01030374001 5079367 5084233 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01009810001 11425591 11427463 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004197 cysteine-type endopeptidase activity GSVIVG01009810001 11425591 11427463 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01009810001 11425591 11427463 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01009810001 11425591 11427463 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01017251001 5900459 5916935 GSVIVG01038219001 24444466 24453192 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2 pyruvate = 2-acetolactate + CO2. IEA GO:0003984 acetolactate synthase activity GSVIVG01038219001 24444466 24453192 GO:0009082 branched chain family amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. IEA Catalysis of the reaction: 2 pyruvate = 2-acetolactate + CO2. IEA GO:0003984 acetolactate synthase activity GSVIVG01038219001 24444466 24453192 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. IEA GO:0016597 amino acid binding GSVIVG01038219001 24444466 24453192 GO:0009082 branched chain family amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. IEA Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. IEA GO:0016597 amino acid binding GSVIVG01024919001 6031978 6037401 GSVIVG01036987001 9223730 9231652 GSVIVG01010649001 15627851 15628262 Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GSVIVG01036138001 20242823 20245113 GSVIVG01025847001 11257296 11264525 GO:0046373 L-arabinose metabolic process The chemical reactions and pathways involving L-arabinose, the D-enantiomer of arabino-pentose. L-arabinose occurs free, e.g. in the heartwood of many conifers, and in the combined state, in both furanose and pyranose forms, as a constituent of various plant hemicelluloses, bacterial polysaccharides etc. IEA Catalysis of the hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides. IEA GO:0046556 alpha-N-arabinofuranosidase activity GSVIVG01001245001 4438688 4439134 GSVIVG01027991001 3041424 3045918 GSVIVG01035535001 2098205 2102566 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035535001 2098205 2102566 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008143001 5399435 5414482 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01025868001 10978235 10995752 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01038554001 21906820 21912924 GSVIVG01024352001 1327801 1328814 GO:0032957 inositol trisphosphate metabolic process The chemical reactions and pathways involving myo-inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with three phosphate groups attached. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01024352001 1327801 1328814 GO:0032957 inositol trisphosphate metabolic process The chemical reactions and pathways involving myo-inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with three phosphate groups attached. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024352001 1327801 1328814 GO:0032957 inositol trisphosphate metabolic process The chemical reactions and pathways involving myo-inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with three phosphate groups attached. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reactions: ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate and ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate. IEA GO:0035300 inositol-1,3,4-trisphosphate 5/6-kinase activity GSVIVG01024352001 1327801 1328814 GO:0032957 inositol trisphosphate metabolic process The chemical reactions and pathways involving myo-inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with three phosphate groups attached. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: 1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP. IEA GO:0047325 inositol tetrakisphosphate 1-kinase activity GSVIVG01003610001 11226339 11228800 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01007637001 10966272 10980533 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01007637001 10966272 10980533 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01007637001 10966272 10980533 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01007637001 10966272 10980533 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021206001 2545291 2546883 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01021206001 2545291 2546883 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01021206001 2545291 2546883 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01021206001 2545291 2546883 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01030192001 10683123 10683284 GO:0009664 plant-type cell wall organization A process that results in the assembly and arrangement of constituent parts of the cellulose and pectin-containing cell wall, or in the disassembly of the cellulose and pectin-containing cell wall. This process is carried out at the cellular level. An example of this process is found in Arabidopsis thaliana. IEA GSVIVG01022498001 3936945 3969388 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin. IEA GO:0004221 ubiquitin thiolesterase activity GSVIVG01033423001 20838102 20840810 GSVIVG01013477001 67891 70298 GSVIVG01003175001 5973765 5975813 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01015926001 15225181 15230373 GSVIVG01030651001 7501290 7502124 GSVIVG01007609001 11295635 11297606 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01006906001 29028963 29039004 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01006906001 29028963 29039004 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01006906001 29028963 29039004 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01006906001 29028963 29039004 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001781001 3044852 3048436 GSVIVG01007875001 8047115 8103821 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01007875001 8047115 8103821 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01007875001 8047115 8103821 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01007875001 8047115 8103821 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01007875001 8047115 8103821 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007875001 8047115 8103821 Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01007875001 8047115 8103821 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01007875001 8047115 8103821 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01019782001 3250301 3255775 GSVIVG01036374001 4325086 4334744 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01036374001 4325086 4334744 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01029310001 17108053 17117620 GSVIVG01022534001 4475297 4488012 GSVIVG01017654001 2403217 2408128 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01017654001 2403217 2408128 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01017654001 2403217 2408128 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01021538001 6774631 6791629 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01021538001 6774631 6791629 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01021538001 6774631 6791629 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021538001 6774631 6791629 Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01024562001 8835674 8841008 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01024562001 8835674 8841008 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01024562001 8835674 8841008 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01024562001 8835674 8841008 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01000850001 2899484 2926873 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01000850001 2899484 2926873 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000850001 2899484 2926873 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids. IEA GO:0004518 nuclease activity GSVIVG01000850001 2899484 2926873 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033381001 21070354 21073576 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01001955001 16083440 16094232 GSVIVG01001893001 6885589 6886020 GSVIVG01023872001 2833610 2847123 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01037832001 7389633 7402240 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01037832001 7389633 7402240 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01037832001 7389633 7402240 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01033478001 20382054 20383898 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GSVIVG01031143001 1771266 1776434 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01001075001 7309323 7313225 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01021656001 8816037 8816258 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01028584001 10205869 10213662 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01028584001 10205869 10213662 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01020002001 11767829 11770802 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005664 nuclear origin of replication recognition complex A multisubunit complex that is located at the replication origins of a chromosome in the nucleus. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01022373001 19236603 19258792 GSVIVG01022371001 19192304 19193055 GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA GSVIVG01010386001 20043838 20044304 GSVIVG01014662001 8315682 8317995 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01014662001 8315682 8317995 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005267 potassium channel activity GSVIVG01025020001 5219447 5221838 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025020001 5219447 5221838 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01031082001 2507216 2508202 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with manganese (Mn) ions. IEA GO:0030145 manganese ion binding GSVIVG01031082001 2507216 2508202 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Functions in the storage of nutritious substrates. IEA GO:0045735 nutrient reservoir activity GSVIVG01032713001 1316660 1322753 GSVIVG01010213001 17603865 17604970 GSVIVG01013597001 21344513 21350838 GSVIVG01036612001 19227443 19228471 Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate. IEA GO:0008146 sulfotransferase activity GSVIVG01018217001 13131131 13135439 GSVIVG01031333001 307222 307932 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01031333001 307222 307932 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01006731001 27818658 27825706 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin. IEA GO:0004221 ubiquitin thiolesterase activity GSVIVG01006731001 27818658 27825706 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01019838001 3790321 3791061 GSVIVG01031543001 17352187 17354095 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031543001 17352187 17354095 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01031543001 17352187 17354095 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01029345001 14857051 14870612 GSVIVG01017697001 2734308 2737282 GSVIVG01036871001 18405633 18408786 GSVIVG01037363001 15013314 15014594 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01015452001 3804662 3805199 GSVIVG01033505001 20198499 20199195 GO:0009790 embryo development The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant. IEA GSVIVG01025529001 14283519 14292617 GO:0006526 arginine biosynthetic process The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid. IEA Catalysis of the reaction: N2-acetyl-L-ornithine + L-glutamate = L-ornithine + N-acetyl-L-glutamate. IEA GO:0004358 glutamate N-acetyltransferase activity GSVIVG01014858001 10694908 10702975 GSVIVG01032632001 2012817 2037101 GSVIVG01000856001 3082059 3092089 GSVIVG01023909001 2530531 2532361 GSVIVG01010531001 21510138 21511444 GSVIVG01013115001 8123287 8139515 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013115001 8123287 8139515 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01006381001 25405599 25407098 GSVIVG01036218001 8809171 8824989 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004197 cysteine-type endopeptidase activity GSVIVG01017860001 4097241 4111878 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033605001 19382969 19384994 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01033605001 19382969 19384994 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01033605001 19382969 19384994 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01033605001 19382969 19384994 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the reaction: ATP + pyruvate = ADP + phosphoenolpyruvate. IEA GO:0004743 pyruvate kinase activity GSVIVG01033605001 19382969 19384994 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA Catalysis of the reaction: ATP + pyruvate = ADP + phosphoenolpyruvate. IEA GO:0004743 pyruvate kinase activity GSVIVG01033605001 19382969 19384994 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA Catalysis of the reaction: ATP + pyruvate = ADP + phosphoenolpyruvate. IEA GO:0004743 pyruvate kinase activity GSVIVG01033605001 19382969 19384994 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Interacting selectively and non-covalently with potassium (K+) ions. IEA GO:0030955 potassium ion binding GSVIVG01033605001 19382969 19384994 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA Interacting selectively and non-covalently with potassium (K+) ions. IEA GO:0030955 potassium ion binding GSVIVG01033605001 19382969 19384994 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA Interacting selectively and non-covalently with potassium (K+) ions. IEA GO:0030955 potassium ion binding GSVIVG01033605001 19382969 19384994 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01033605001 19382969 19384994 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01033605001 19382969 19384994 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01028575001 10085443 10086284 GSVIVG01009888001 12141417 12144105 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01009888001 12141417 12144105 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01017857001 4071957 4073491 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01006310001 24796712 24799157 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01006310001 24796712 24799157 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01006310001 24796712 24799157 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01006310001 24796712 24799157 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01006310001 24796712 24799157 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01006310001 24796712 24799157 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01006310001 24796712 24799157 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01006310001 24796712 24799157 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01006310001 24796712 24799157 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01006310001 24796712 24799157 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01037100001 29155211 29158436 GSVIVG01018959001 18349890 18353020 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018959001 18349890 18353020 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018959001 18349890 18353020 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018959001 18349890 18353020 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018959001 18349890 18353020 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01018959001 18349890 18353020 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01018959001 18349890 18353020 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01018959001 18349890 18353020 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01023069001 15920274 15921023 GSVIVG01036463001 22341059 22350324 GSVIVG01001859001 84554 104999 GSVIVG01025965001 26502442 26503608 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029320001 16919662 16924264 GSVIVG01003800001 242029 265940 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01038683001 21028691 21038014 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01019675001 2386824 2397387 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01019675001 2386824 2397387 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01012245001 246096 257603 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01003914001 13536190 13543233 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01023874001 2814403 2814940 GSVIVG01025137001 4043751 4048916 GSVIVG01001759001 6212725 6215304 GSVIVG01037043001 8431961 8436443 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01037043001 8431961 8436443 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01037043001 8431961 8436443 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the reaction: ATP + pyruvate = ADP + phosphoenolpyruvate. IEA GO:0004743 pyruvate kinase activity GSVIVG01037043001 8431961 8436443 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Interacting selectively and non-covalently with potassium (K+) ions. IEA GO:0030955 potassium ion binding GSVIVG01036925001 17515272 17517964 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01036925001 17515272 17517964 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01036925001 17515272 17517964 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01036925001 17515272 17517964 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01036925001 17515272 17517964 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034936001 243883 246638 GSVIVG01014146001 802611 802772 GSVIVG01033933001 16609391 16615735 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage. IEA GO:0016209 antioxidant activity GSVIVG01033933001 16609391 16615735 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01036301001 3547499 3554038 GSVIVG01002745001 36297656 36299506 GSVIVG01018892001 18877449 18887691 GSVIVG01023157001 21802861 21807692 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar. IEA GO:0008375 acetylglucosaminyltransferase activity GSVIVG01001350001 23864997 23865889 GO:0006869 lipid transport The directed movement of lipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Interacting selectively and non-covalently with a lipid. IEA GO:0008289 lipid binding GSVIVG01026871001 19739211 19749790 GSVIVG01029488001 22339830 22346383 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029488001 22339830 22346383 Catalysis of the transfer of a functional group from one position to another within a single molecule. IEA GO:0016866 intramolecular transferase activity GSVIVG01032796001 712916 714472 GSVIVG01031797001 4445631 4446279 Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01031797001 4445631 4446279 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01010301001 19214737 19218992 GSVIVG01027297001 16983277 16983634 GSVIVG01030288001 9439579 9443013 GSVIVG01028183001 4468038 4471083 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01013209001 6688051 6695865 GSVIVG01008671001 1093021 1094144 GSVIVG01021143001 1791764 1793924 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01021143001 1791764 1793924 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01021143001 1791764 1793924 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01021143001 1791764 1793924 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01021143001 1791764 1793924 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01021143001 1791764 1793924 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01021143001 1791764 1793924 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01021143001 1791764 1793924 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01021143001 1791764 1793924 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01021143001 1791764 1793924 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01021143001 1791764 1793924 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01021143001 1791764 1793924 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01021143001 1791764 1793924 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01021143001 1791764 1793924 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01021143001 1791764 1793924 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01006682001 27460645 27461032 GSVIVG01015085001 925656 928593 GSVIVG01008276001 3700340 3715271 GSVIVG01030414001 5391253 5392228 GSVIVG01025476001 504875 508163 GSVIVG01009017001 4310332 4319333 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01011334001 8665113 8695586 GSVIVG01017622001 2079214 2088745 GSVIVG01013053001 9137680 9153416 GO:0006351 transcription, DNA-dependent The cellular synthesis of RNA on a template of DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01013053001 9137680 9153416 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01013053001 9137680 9153416 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01013053001 9137680 9153416 GO:0006351 transcription, DNA-dependent The cellular synthesis of RNA on a template of DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01013053001 9137680 9153416 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01013053001 9137680 9153416 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01013053001 9137680 9153416 GO:0006351 transcription, DNA-dependent The cellular synthesis of RNA on a template of DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01013053001 9137680 9153416 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01013053001 9137680 9153416 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01013053001 9137680 9153416 GO:0006351 transcription, DNA-dependent The cellular synthesis of RNA on a template of DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01013053001 9137680 9153416 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01013053001 9137680 9153416 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01033851001 17243036 17251002 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01033851001 17243036 17251002 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds. IEA GO:0015035 protein disulfide oxidoreductase activity GSVIVG01016044001 17812311 17812659 GSVIVG01025615001 13555050 13561410 GSVIVG01034964001 487690 494963 GO:0006012 galactose metabolic process The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + D-galactose = ADP + D-galactose 1-phosphate. IEA GO:0004335 galactokinase activity GSVIVG01034964001 487690 494963 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + D-galactose = ADP + D-galactose 1-phosphate. IEA GO:0004335 galactokinase activity GSVIVG01034964001 487690 494963 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + D-galactose = ADP + D-galactose 1-phosphate. IEA GO:0004335 galactokinase activity GSVIVG01034964001 487690 494963 GO:0046835 carbohydrate phosphorylation The process of introducing a phosphate group into a carbohydrate, any organic compound based on the general formula Cx(H2O)y. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + D-galactose = ADP + D-galactose 1-phosphate. IEA GO:0004335 galactokinase activity GSVIVG01034964001 487690 494963 GO:0006012 galactose metabolic process The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034964001 487690 494963 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034964001 487690 494963 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034964001 487690 494963 GO:0046835 carbohydrate phosphorylation The process of introducing a phosphate group into a carbohydrate, any organic compound based on the general formula Cx(H2O)y. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034964001 487690 494963 GO:0006012 galactose metabolic process The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01034964001 487690 494963 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01034964001 487690 494963 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01034964001 487690 494963 GO:0046835 carbohydrate phosphorylation The process of introducing a phosphate group into a carbohydrate, any organic compound based on the general formula Cx(H2O)y. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01034964001 487690 494963 GO:0006012 galactose metabolic process The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01034964001 487690 494963 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01034964001 487690 494963 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01034964001 487690 494963 GO:0046835 carbohydrate phosphorylation The process of introducing a phosphate group into a carbohydrate, any organic compound based on the general formula Cx(H2O)y. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01001028001 20318892 20319143 GSVIVG01014977001 13551127 13555600 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01014977001 13551127 13555600 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01014977001 13551127 13555600 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01014977001 13551127 13555600 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01014977001 13551127 13555600 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01014977001 13551127 13555600 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01021270001 3247622 3251811 GSVIVG01034561001 19462139 19464089 GSVIVG01033450001 20604958 20605143 GSVIVG01010590001 16268747 16270553 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010590001 16268747 16270553 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010590001 16268747 16270553 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010590001 16268747 16270553 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010590001 16268747 16270553 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010590001 16268747 16270553 GO:0009813 flavonoid biosynthetic process The chemical reactions and pathways resulting in the formation of flavonoids, a group of phenolic derivatives containing a flavan skeleton. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010590001 16268747 16270553 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01010590001 16268747 16270553 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01010590001 16268747 16270553 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01010590001 16268747 16270553 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01010590001 16268747 16270553 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01010590001 16268747 16270553 GO:0009813 flavonoid biosynthetic process The chemical reactions and pathways resulting in the formation of flavonoids, a group of phenolic derivatives containing a flavan skeleton. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01010590001 16268747 16270553 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01010590001 16268747 16270553 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01010590001 16268747 16270553 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01010590001 16268747 16270553 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01010590001 16268747 16270553 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01010590001 16268747 16270553 GO:0009813 flavonoid biosynthetic process The chemical reactions and pathways resulting in the formation of flavonoids, a group of phenolic derivatives containing a flavan skeleton. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01010590001 16268747 16270553 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01010590001 16268747 16270553 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01010590001 16268747 16270553 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01010590001 16268747 16270553 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01010590001 16268747 16270553 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01010590001 16268747 16270553 GO:0009813 flavonoid biosynthetic process The chemical reactions and pathways resulting in the formation of flavonoids, a group of phenolic derivatives containing a flavan skeleton. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01010590001 16268747 16270553 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: 3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + 3,4',5-trihydroxy-stilbene + 4 CO2. IEA GO:0050350 trihydroxystilbene synthase activity GSVIVG01010590001 16268747 16270553 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: 3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + 3,4',5-trihydroxy-stilbene + 4 CO2. IEA GO:0050350 trihydroxystilbene synthase activity GSVIVG01010590001 16268747 16270553 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: 3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + 3,4',5-trihydroxy-stilbene + 4 CO2. IEA GO:0050350 trihydroxystilbene synthase activity GSVIVG01010590001 16268747 16270553 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: 3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + 3,4',5-trihydroxy-stilbene + 4 CO2. IEA GO:0050350 trihydroxystilbene synthase activity GSVIVG01010590001 16268747 16270553 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: 3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + 3,4',5-trihydroxy-stilbene + 4 CO2. IEA GO:0050350 trihydroxystilbene synthase activity GSVIVG01010590001 16268747 16270553 GO:0009813 flavonoid biosynthetic process The chemical reactions and pathways resulting in the formation of flavonoids, a group of phenolic derivatives containing a flavan skeleton. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: 3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + 3,4',5-trihydroxy-stilbene + 4 CO2. IEA GO:0050350 trihydroxystilbene synthase activity GSVIVG01003286001 14139645 14142958 GSVIVG01034162001 14732961 14734962 GO:0009664 plant-type cell wall organization A process that results in the assembly and arrangement of constituent parts of the cellulose and pectin-containing cell wall, or in the disassembly of the cellulose and pectin-containing cell wall. This process is carried out at the cellular level. An example of this process is found in Arabidopsis thaliana. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA GSVIVG01034162001 14732961 14734962 GO:0009664 plant-type cell wall organization A process that results in the assembly and arrangement of constituent parts of the cellulose and pectin-containing cell wall, or in the disassembly of the cellulose and pectin-containing cell wall. This process is carried out at the cellular level. An example of this process is found in Arabidopsis thaliana. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01033142001 8358356 8364248 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033142001 8358356 8364248 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033142001 8358356 8364248 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033142001 8358356 8364248 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033142001 8358356 8364248 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01033142001 8358356 8364248 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01001366001 24027379 24029185 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01001366001 24027379 24029185 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01001366001 24027379 24029185 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01001366001 24027379 24029185 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01001366001 24027379 24029185 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01001366001 24027379 24029185 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01001366001 24027379 24029185 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any transcription regulator activity required for initiation or upregulation of transcription. IEA GO:0016563 transcription activator activity GSVIVG01001366001 24027379 24029185 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any transcription regulator activity required for initiation or upregulation of transcription. IEA GO:0016563 transcription activator activity GSVIVG01001366001 24027379 24029185 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any transcription regulator activity required for initiation or upregulation of transcription. IEA GO:0016563 transcription activator activity GSVIVG01001366001 24027379 24029185 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01001366001 24027379 24029185 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01001366001 24027379 24029185 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01001366001 24027379 24029185 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01001366001 24027379 24029185 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01001366001 24027379 24029185 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01003453001 10355142 10357064 GSVIVG01017495001 9447376 9449877 GSVIVG01010179001 16879404 16894049 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01021159001 1993228 2008881 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01021159001 1993228 2008881 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01021159001 1993228 2008881 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01021159001 1993228 2008881 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01021159001 1993228 2008881 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01021159001 1993228 2008881 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01013435001 494023 498427 GO:0008299 isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+. IEA GO:0004420 hydroxymethylglutaryl-CoA reductase (NADPH) activity GSVIVG01013435001 494023 498427 GO:0015936 coenzyme A metabolic process The chemical reactions and pathways involving coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+. IEA GO:0004420 hydroxymethylglutaryl-CoA reductase (NADPH) activity GSVIVG01013435001 494023 498427 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+. IEA GO:0004420 hydroxymethylglutaryl-CoA reductase (NADPH) activity GSVIVG01013435001 494023 498427 GO:0008299 isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01013435001 494023 498427 GO:0015936 coenzyme A metabolic process The chemical reactions and pathways involving coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01013435001 494023 498427 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01013435001 494023 498427 GO:0008299 isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01013435001 494023 498427 GO:0015936 coenzyme A metabolic process The chemical reactions and pathways involving coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01013435001 494023 498427 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01013435001 494023 498427 GO:0008299 isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01013435001 494023 498427 GO:0015936 coenzyme A metabolic process The chemical reactions and pathways involving coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01013435001 494023 498427 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01004003001 14227496 14253328 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2 pyruvate = 2-acetolactate + CO2. IEA GO:0003984 acetolactate synthase activity GSVIVG01004003001 14227496 14253328 GO:0009082 branched chain family amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. IEA Catalysis of the reaction: 2 pyruvate = 2-acetolactate + CO2. IEA GO:0003984 acetolactate synthase activity GSVIVG01004003001 14227496 14253328 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. IEA GO:0016597 amino acid binding GSVIVG01004003001 14227496 14253328 GO:0009082 branched chain family amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. IEA Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. IEA GO:0016597 amino acid binding GSVIVG01007585001 11632897 11634953 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004197 cysteine-type endopeptidase activity GSVIVG01007585001 11632897 11634953 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004197 cysteine-type endopeptidase activity GSVIVG01007585001 11632897 11634953 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004197 cysteine-type endopeptidase activity GSVIVG01007585001 11632897 11634953 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004197 cysteine-type endopeptidase activity GSVIVG01007585001 11632897 11634953 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01007585001 11632897 11634953 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01007585001 11632897 11634953 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01007585001 11632897 11634953 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01007585001 11632897 11634953 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01007585001 11632897 11634953 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01007585001 11632897 11634953 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01007585001 11632897 11634953 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01033811001 17579828 17586161 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01033811001 17579828 17586161 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01033811001 17579828 17586161 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01033811001 17579828 17586161 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01033811001 17579828 17586161 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. IEA GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity GSVIVG01033811001 17579828 17586161 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. IEA GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity GSVIVG01033811001 17579828 17586161 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033811001 17579828 17586161 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033811001 17579828 17586161 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01033811001 17579828 17586161 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01033811001 17579828 17586161 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01033811001 17579828 17586161 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01012928001 13685062 13685812 GSVIVG01034624001 13872517 13874545 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GSVIVG01035547001 2193002 2196242 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01021954001 5190546 5191789 GSVIVG01038715001 20662035 20665713 GSVIVG01012662001 414663 422180 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01012662001 414663 422180 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01012662001 414663 422180 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01012662001 414663 422180 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01012662001 414663 422180 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01012662001 414663 422180 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01012662001 414663 422180 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012662001 414663 422180 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019348001 686324 687025 GSVIVG01028893001 17754301 17767006 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01028893001 17754301 17767006 GO:0032259 methylation The process by which a methyl group is covalently attached to a molecule. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01028893001 17754301 17767006 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01028893001 17754301 17767006 GO:0032259 methylation The process by which a methyl group is covalently attached to a molecule. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01009972001 12954358 12956416 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009972001 12954358 12956416 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009972001 12954358 12956416 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01009972001 12954358 12956416 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01009972001 12954358 12956416 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01009972001 12954358 12956416 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01009972001 12954358 12956416 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01009972001 12954358 12956416 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022108001 16624246 16640523 GSVIVG01022973001 17398801 17400234 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01022973001 17398801 17400234 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01035145001 1845280 1854311 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01003747001 7564902 7565228 GSVIVG01013187001 6975041 6977508 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030362001 5006920 5011678 GSVIVG01002606001 35405444 35406638 GSVIVG01016436001 3930425 3932488 GSVIVG01012779001 23364125 23402122 GSVIVG01029162001 18998253 19005594 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01029162001 18998253 19005594 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01029162001 18998253 19005594 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01029162001 18998253 19005594 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01029162001 18998253 19005594 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01029162001 18998253 19005594 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01029162001 18998253 19005594 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01029162001 18998253 19005594 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01030512001 6352396 6365926 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01021330001 4121172 4123658 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01021330001 4121172 4123658 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01010490001 21029844 21031391 GSVIVG01034535001 19720789 19740328 GSVIVG01003114001 7363227 7369423 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01003114001 7363227 7369423 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01034676001 7501880 7506313 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01034676001 7501880 7506313 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01032925001 24220056 24222005 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01016173001 7065046 7065253 GSVIVG01027790001 7792153 7793327 GSVIVG01025897001 27404735 27407557 GSVIVG01031508001 17809104 17809535 GSVIVG01022861001 18688488 18689104 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01009931001 12501749 12507830 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009931001 12501749 12507830 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009931001 12501749 12507830 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01009931001 12501749 12507830 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01022062001 16296547 16298130 GSVIVG01034501001 20255699 20261741 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule. IEA GO:0000175 3'-5'-exoribonuclease activity GSVIVG01034501001 20255699 20261741 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule. IEA GO:0000175 3'-5'-exoribonuclease activity GSVIVG01034501001 20255699 20261741 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01034501001 20255699 20261741 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01034501001 20255699 20261741 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01034501001 20255699 20261741 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01034501001 20255699 20261741 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01034501001 20255699 20261741 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01009410001 8135122 8137527 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01009410001 8135122 8137527 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01009410001 8135122 8137527 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01009410001 8135122 8137527 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01009410001 8135122 8137527 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01009410001 8135122 8137527 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01009410001 8135122 8137527 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009410001 8135122 8137527 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009410001 8135122 8137527 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01009410001 8135122 8137527 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01016575001 2669794 2678963 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016575001 2669794 2678963 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016575001 2669794 2678963 GO:0006431 methionyl-tRNA aminoacylation The process of coupling methionine to methionyl-tRNA, catalyzed by methionyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016575001 2669794 2678963 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01016575001 2669794 2678963 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01016575001 2669794 2678963 GO:0006431 methionyl-tRNA aminoacylation The process of coupling methionine to methionyl-tRNA, catalyzed by methionyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01016575001 2669794 2678963 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met). IEA GO:0004825 methionine-tRNA ligase activity GSVIVG01016575001 2669794 2678963 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met). IEA GO:0004825 methionine-tRNA ligase activity GSVIVG01016575001 2669794 2678963 GO:0006431 methionyl-tRNA aminoacylation The process of coupling methionine to methionyl-tRNA, catalyzed by methionyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met). IEA GO:0004825 methionine-tRNA ligase activity GSVIVG01016575001 2669794 2678963 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016575001 2669794 2678963 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016575001 2669794 2678963 GO:0006431 methionyl-tRNA aminoacylation The process of coupling methionine to methionyl-tRNA, catalyzed by methionyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031605001 18853399 18854607 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01009608001 9846632 9858576 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01009608001 9846632 9858576 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01009608001 9846632 9858576 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01009608001 9846632 9858576 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01006303001 24758308 24760820 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01006303001 24758308 24760820 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01006303001 24758308 24760820 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01006303001 24758308 24760820 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01006303001 24758308 24760820 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01006303001 24758308 24760820 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01006303001 24758308 24760820 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01006303001 24758308 24760820 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016772001 1222972 1224352 GSVIVG01036490001 22622917 22623777 GO:0006597 spermine biosynthetic process The chemical reactions and pathways resulting in the formation of spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses and involved in nucleic acid packaging. IEA Catalysis of the reaction: S-adenosyl-L-methionine = (5-deoxy-5-adenosyl)(3-aminopropyl) methylsulfonium salt + CO2. IEA GO:0004014 adenosylmethionine decarboxylase activity GSVIVG01036490001 22622917 22623777 GO:0008295 spermidine biosynthetic process The chemical reactions and pathways resulting in the formation of spermidine, N-(3-aminopropyl)-1,4-diaminobutane. IEA Catalysis of the reaction: S-adenosyl-L-methionine = (5-deoxy-5-adenosyl)(3-aminopropyl) methylsulfonium salt + CO2. IEA GO:0004014 adenosylmethionine decarboxylase activity GSVIVG01022315001 18419719 18421916 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030145001 10285351 10287914 GSVIVG01016511001 3260896 3269116 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016511001 3260896 3269116 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01031035001 21210990 21212344 GSVIVG01031250001 799206 817337 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the reaction: pectin + n H2O = n methanol + pectate. IEA GO:0030599 pectinesterase activity GSVIVG01033678001 18752299 18753373 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01018326001 11003261 11012492 GO:0005956 protein kinase CK2 complex A protein complex that possesses protein serine/threonine kinase activity, and contains two catalytic alpha subunits and two regulatory beta subunits. Protein kinase CK2 complexes are found in nearly every subcellular compartment, and can phosphorylate many protein substrates in addition to casein. IEA Modulates the activity of a protein kinase, an enzyme which phosphorylates a protein. IEA GO:0019887 protein kinase regulator activity GSVIVG01035272001 11741836 11744258 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018654001 11604752 11606447 GSVIVG01026427001 23692720 23693812 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01022012001 4312482 4330399 GSVIVG01005612001 40870605 40871970 GSVIVG01014052001 10106561 10117840 GO:0006383 transcription from RNA polymerase III promoter The synthesis of RNA from a DNA template by RNA polymerase III (Pol III), originating at a Pol III-specific promoter. IEA GO:0005666 DNA-directed RNA polymerase III complex RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01014052001 10106561 10117840 GO:0006383 transcription from RNA polymerase III promoter The synthesis of RNA from a DNA template by RNA polymerase III (Pol III), originating at a Pol III-specific promoter. IEA GO:0005666 DNA-directed RNA polymerase III complex RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01018017001 5505841 5509295 GSVIVG01018861001 19151034 19152506 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018861001 19151034 19152506 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain. IEA GO:0004177 aminopeptidase activity GSVIVG01035054001 1228360 1229010 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GSVIVG01035054001 1228360 1229010 GO:0009607 response to biotic stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism. IEA GSVIVG01031317001 413352 416102 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031317001 413352 416102 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031317001 413352 416102 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01031317001 413352 416102 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01031317001 413352 416102 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01031317001 413352 416102 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01038589001 21677420 21681935 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01038589001 21677420 21681935 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01020475001 18872620 18880961 GSVIVG01021093001 1403637 1406467 GSVIVG01032493001 27872802 27878034 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019842001 3801948 3805389 GSVIVG01032166001 21879686 21898941 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0000159 protein phosphatase type 2A complex A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit. IEA Modulation of the activity of the enzyme protein phosphatase type 2A. IEA GO:0008601 protein phosphatase type 2A regulator activity GSVIVG01014145001 793325 800964 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014145001 793325 800964 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014145001 793325 800964 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014145001 793325 800964 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014145001 793325 800964 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017858001 4073696 4088090 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017858001 4073696 4088090 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030131 clathrin adaptor complex A membrane coat adaptor complex that links clathrin to a membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023040001 16499850 16500267 GSVIVG01005842001 22191914 22199863 GO:0006308 DNA catabolic process The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01005842001 22191914 22199863 GO:0006308 DNA catabolic process The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. IEA GO:0004519 endonuclease activity GSVIVG01005842001 22191914 22199863 GO:0006308 DNA catabolic process The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01028823001 18360079 18360711 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01028823001 18360079 18360711 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01003300001 8663529 8675771 GO:0006744 ubiquinone biosynthetic process The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme. IEA Catalysis of the reaction: 2-polyprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine. IEA GO:0008425 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity GSVIVG01029176001 18939068 18939554 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01031042001 21304811 21306345 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031042001 21304811 21306345 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031042001 21304811 21306345 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01031042001 21304811 21306345 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01011756001 4474857 4477428 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01016607001 2461431 2464394 GSVIVG01031904001 5278122 5285565 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031904001 5278122 5285565 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01007332001 31408510 31413582 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007332001 31408510 31413582 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01023499001 10918009 10935050 GSVIVG01013044001 9325319 9325519 GSVIVG01023001001 17090395 17095835 Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01023001001 17090395 17095835 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01026938001 19232826 19241737 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01011074001 1798540 1804721 GSVIVG01034904001 16288125 16293527 GSVIVG01016684001 356770 358115 GSVIVG01033367001 21179114 21180988 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01033367001 21179114 21180988 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01033367001 21179114 21180988 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01033367001 21179114 21180988 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01010892001 16213276 16217511 GSVIVG01012690001 672247 673062 GSVIVG01020452001 19190007 19191200 GSVIVG01038229001 24497335 24504338 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01038229001 24497335 24504338 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01038229001 24497335 24504338 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01038229001 24497335 24504338 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01006388001 25541234 25557994 GSVIVG01003132001 7523488 7524903 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01032805001 610469 614552 GO:0006568 tryptophan metabolic process The chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032805001 610469 614552 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032805001 610469 614552 GO:0006568 tryptophan metabolic process The chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid. IEA Catalysis of the reaction: N-(5-phospho-beta-D-ribosyl)-anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate. IEA GO:0004640 phosphoribosylanthranilate isomerase activity GSVIVG01032805001 610469 614552 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: N-(5-phospho-beta-D-ribosyl)-anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate. IEA GO:0004640 phosphoribosylanthranilate isomerase activity GSVIVG01032353001 26614749 26625494 GSVIVG01009274001 6881993 6883411 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01009274001 6881993 6883411 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01009274001 6881993 6883411 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01009274001 6881993 6883411 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01009274001 6881993 6883411 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01009274001 6881993 6883411 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01009274001 6881993 6883411 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01009274001 6881993 6883411 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01002110001 32989595 32989639 GSVIVG01001789001 3168796 3175431 GSVIVG01001399001 24216068 24277215 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01001399001 24216068 24277215 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01001399001 24216068 24277215 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01001399001 24216068 24277215 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01001399001 24216068 24277215 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01001399001 24216068 24277215 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01001399001 24216068 24277215 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01001399001 24216068 24277215 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01001399001 24216068 24277215 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01001399001 24216068 24277215 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001399001 24216068 24277215 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001399001 24216068 24277215 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001399001 24216068 24277215 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01001399001 24216068 24277215 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01001399001 24216068 24277215 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01022353001 18907217 18921354 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01022353001 18907217 18921354 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01022353001 18907217 18921354 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01031885001 5156561 5164408 Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01031885001 5156561 5164408 Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01031885001 5156561 5164408 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01031885001 5156561 5164408 Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01010850001 23339213 23345975 GSVIVG01017779001 3423538 3426163 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01017779001 3423538 3426163 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01017779001 3423538 3426163 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01017779001 3423538 3426163 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019483001 1009740 1014911 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01019483001 1009740 1014911 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01019483001 1009740 1014911 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01019483001 1009740 1014911 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007736001 9722892 9727154 GSVIVG01034167001 14698495 14703129 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01034167001 14698495 14703129 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01023364001 19258693 19259456 GSVIVG01018940001 18518533 18521845 GSVIVG01007928001 7465853 7468766 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01010781001 22523023 22538810 GSVIVG01009809001 11419071 11420594 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004197 cysteine-type endopeptidase activity GSVIVG01009809001 11419071 11420594 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01020788001 1956313 1963426 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA Catalysis of the transfer of the amide nitrogen of glutamine to a variety of substrates. GATases catalyze two separate reactions at two active sites, which are located either on a single polypeptide chain or on different subunits. In the glutaminase reaction, glutamine is hydrolyzed to glutamate and ammonia, which is added to an acceptor substrate in the synthase reaction. IEA GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor GSVIVG01028927001 17429551 17447121 GSVIVG01017520001 9858782 9861200 GSVIVG01016503001 3337584 3339850 The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01013689001 2665385 2668050 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01013689001 2665385 2668050 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01013689001 2665385 2668050 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01013689001 2665385 2668050 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01013689001 2665385 2668050 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01013689001 2665385 2668050 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01030466001 5841197 5844704 GSVIVG01012033001 1989810 1993774 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GSVIVG01009673001 10356445 10357646 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). IEA GO:0003755 peptidyl-prolyl cis-trans isomerase activity GSVIVG01009673001 10356445 10357646 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). IEA GO:0003755 peptidyl-prolyl cis-trans isomerase activity GSVIVG01009673001 10356445 10357646 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01009673001 10356445 10357646 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01009673001 10356445 10357646 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01009673001 10356445 10357646 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01009673001 10356445 10357646 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01009673001 10356445 10357646 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01009673001 10356445 10357646 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01009673001 10356445 10357646 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01009205001 6227653 6234972 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01009205001 6227653 6234972 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020664001 3295350 3297158 GSVIVG01013401001 691256 696212 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01013401001 691256 696212 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01013401001 691256 696212 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01013401001 691256 696212 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01013401001 691256 696212 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01013401001 691256 696212 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01013401001 691256 696212 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01013401001 691256 696212 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01013401001 691256 696212 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01013401001 691256 696212 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01024385001 1905332 1907861 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01024745001 7249262 7254568 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01024745001 7249262 7254568 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of a calcium ion by a voltage-gated channel. IEA GO:0005245 voltage-gated calcium channel activity GSVIVG01024745001 7249262 7254568 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01003952001 14006939 14007430 GSVIVG01014840001 10434342 10444022 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01004814001 120590 131209 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01004814001 120590 131209 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01004814001 120590 131209 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01031659001 19721253 19736794 GSVIVG01001209001 774533 784432 GSVIVG01031425001 18750287 18767319 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01003569001 14731136 14732465 GSVIVG01022815001 16907060 16934249 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01022134001 16842364 16845208 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01022134001 16842364 16845208 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01011905001 3112077 3117575 GSVIVG01034750001 8951830 8957630 GSVIVG01011188001 7969362 7970248 GSVIVG01018880001 19011766 19024677 GSVIVG01010770001 22439693 22444842 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01010770001 22439693 22444842 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01030954001 19628803 19652923 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01030954001 19628803 19652923 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01030954001 19628803 19652923 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01030954001 19628803 19652923 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024978001 5564018 5564239 GSVIVG01027181001 17218617 17221906 GO:0008615 pyridoxine biosynthetic process The chemical reactions and pathways resulting in the formation of pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, one of the vitamin B6 compounds. IEA Catalysis of the reaction: pyridoxamine 5'-phosphate + H2O + O2 = pyridoxal 5'-phosphate + NH3 + H2O2. IEA GO:0004733 pyridoxamine-phosphate oxidase activity GSVIVG01027181001 17218617 17221906 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: pyridoxamine 5'-phosphate + H2O + O2 = pyridoxal 5'-phosphate + NH3 + H2O2. IEA GO:0004733 pyridoxamine-phosphate oxidase activity GSVIVG01027181001 17218617 17221906 GO:0008615 pyridoxine biosynthetic process The chemical reactions and pathways resulting in the formation of pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, one of the vitamin B6 compounds. IEA Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0010181 FMN binding GSVIVG01027181001 17218617 17221906 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0010181 FMN binding GSVIVG01000730001 243588 247340 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01038656001 21159330 21160238 GSVIVG01008200001 4744622 4762782 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01005870001 22372588 22375417 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01005870001 22372588 22375417 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01005870001 22372588 22375417 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01038625001 21369301 21380824 GSVIVG01029888001 944464 944724 GSVIVG01031579001 18412761 18422972 GSVIVG01011715001 4844836 4848637 GO:0000154 rRNA modification The covalent alteration of one or more nucleotides within an rRNA molecule to produce an rRNA molecule with a sequence that differs from that coded genetically. IEA Catalysis of the dimethylation two adjacent A residues in the loop closing the 3'-terminal stem of the 18S rRNA, using S-adenosyl-L-methionine as a methyl donor. IEA GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity GSVIVG01011715001 4844836 4848637 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the dimethylation two adjacent A residues in the loop closing the 3'-terminal stem of the 18S rRNA, using S-adenosyl-L-methionine as a methyl donor. IEA GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity GSVIVG01011715001 4844836 4848637 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the dimethylation two adjacent A residues in the loop closing the 3'-terminal stem of the 18S rRNA, using S-adenosyl-L-methionine as a methyl donor. IEA GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity GSVIVG01011715001 4844836 4848637 GO:0000154 rRNA modification The covalent alteration of one or more nucleotides within an rRNA molecule to produce an rRNA molecule with a sequence that differs from that coded genetically. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01011715001 4844836 4848637 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01011715001 4844836 4848637 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01011715001 4844836 4848637 GO:0000154 rRNA modification The covalent alteration of one or more nucleotides within an rRNA molecule to produce an rRNA molecule with a sequence that differs from that coded genetically. IEA Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule. IEA GO:0008649 rRNA methyltransferase activity GSVIVG01011715001 4844836 4848637 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule. IEA GO:0008649 rRNA methyltransferase activity GSVIVG01011715001 4844836 4848637 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule. IEA GO:0008649 rRNA methyltransferase activity GSVIVG01011715001 4844836 4848637 GO:0000154 rRNA modification The covalent alteration of one or more nucleotides within an rRNA molecule to produce an rRNA molecule with a sequence that differs from that coded genetically. IEA Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid. IEA GO:0008825 cyclopropane-fatty-acyl-phospholipid synthase activity GSVIVG01011715001 4844836 4848637 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid. IEA GO:0008825 cyclopropane-fatty-acyl-phospholipid synthase activity GSVIVG01011715001 4844836 4848637 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid. IEA GO:0008825 cyclopropane-fatty-acyl-phospholipid synthase activity GSVIVG01008290001 3607716 3610689 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01008290001 3607716 3610689 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01025065001 4819054 4820348 GSVIVG01033091001 25653510 25655343 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + Na+(out) = amino acid(in) + Na+(in). IEA GO:0005283 sodium:amino acid symporter activity GSVIVG01013527001 2360459 2387359 GSVIVG01020559001 4363640 4390088 GSVIVG01011970001 2517662 2519101 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01011083001 1742155 1744075 GSVIVG01005601001 40836409 40837933 GSVIVG01020741001 2438863 2445978 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01020741001 2438863 2445978 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01020741001 2438863 2445978 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01020741001 2438863 2445978 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016891001 2321212 2337472 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016891001 2321212 2337472 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016891001 2321212 2337472 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016891001 2321212 2337472 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016891001 2321212 2337472 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016891001 2321212 2337472 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016891001 2321212 2337472 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016891001 2321212 2337472 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016891001 2321212 2337472 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016891001 2321212 2337472 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01016891001 2321212 2337472 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01016891001 2321212 2337472 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01016891001 2321212 2337472 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016891001 2321212 2337472 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016891001 2321212 2337472 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01012437001 757223 770611 GSVIVG01011107001 1521963 1522946 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA Catalysis of the reaction: isopentenyl diphosphate + tRNA = diphosphate + tRNA containing 6-isopentenyladenosine. IEA GO:0004811 tRNA isopentenyltransferase activity GSVIVG01011107001 1521963 1522946 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033378001 21090448 21097354 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033378001 21090448 21097354 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01028031001 3311815 3316380 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01028031001 3311815 3316380 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01023012001 16908450 16911983 GSVIVG01035313001 366545 381751 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01035313001 366545 381751 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01035313001 366545 381751 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01035313001 366545 381751 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035313001 366545 381751 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028304001 5918640 5931499 GSVIVG01031756001 4075994 4091628 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01031756001 4075994 4091628 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01031756001 4075994 4091628 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01031756001 4075994 4091628 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026161001 13194758 13206335 GSVIVG01018500001 14260709 14262625 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018500001 14260709 14262625 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01000887001 3471325 3473607 GSVIVG01001469001 21316389 21357460 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01001469001 21316389 21357460 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01001469001 21316389 21357460 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001469001 21316389 21357460 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021563001 7097968 7131827 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion. IEA GO:0004806 triglyceride lipase activity GSVIVG01036786001 22558794 22573951 GO:0008272 sulfate transport The directed movement of sulfate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the reaction: thiosulfate + cyanide = sulfite + thiocyanate. IEA GO:0004792 thiosulfate sulfurtransferase activity GSVIVG01036786001 22558794 22573951 GO:0008272 sulfate transport The directed movement of sulfate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01018980001 18131144 18134803 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01024865001 6372694 6375974 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01024865001 6372694 6375974 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01037746001 7454669 7455712 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01037746001 7454669 7455712 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01009764001 11105895 11106764 GSVIVG01021663001 8908383 8921192 GSVIVG01035437001 1255450 1257661 GSVIVG01033322001 21514923 21520045 GSVIVG01034366001 17381971 17383391 GSVIVG01012217001 496479 498561 GSVIVG01010634001 15736963 15750200 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01010634001 15736963 15750200 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01010634001 15736963 15750200 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010634001 15736963 15750200 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010634001 15736963 15750200 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01010634001 15736963 15750200 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01010634001 15736963 15750200 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01010634001 15736963 15750200 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01010634001 15736963 15750200 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01010634001 15736963 15750200 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01009978001 12992480 12996865 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide. IEA GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor GSVIVG01038022001 16401287 16406784 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038022001 16401287 16406784 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000858001 3137742 3138935 GSVIVG01028915001 17587951 17591587 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01028915001 17587951 17591587 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. IEA GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GSVIVG01028915001 17587951 17591587 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species. IEA GO:0031418 L-ascorbic acid binding GSVIVG01015432001 3611844 3617566 GSVIVG01004457001 38654728 38661929 GSVIVG01014196001 1383808 1390453 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01014196001 1383808 1390453 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01014196001 1383808 1390453 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01014196001 1383808 1390453 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01014196001 1383808 1390453 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01014196001 1383808 1390453 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01022562001 5104277 5104819 GSVIVG01030491001 6144934 6150368 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005945 6-phosphofructokinase complex A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known. IEA Catalysis of the reaction: ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate. IEA GO:0003872 6-phosphofructokinase activity GSVIVG01030491001 6144934 6150368 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005945 6-phosphofructokinase complex A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030491001 6144934 6150368 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005945 6-phosphofructokinase complex A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known. IEA Catalysis of the reaction: fructose-6-phosphate + pyrophosphate = phosphate + fructose-1,6-bisphosphate. IEA GO:0047334 diphosphate-fructose-6-phosphate 1-phosphotransferase activity GSVIVG01028794001 18744125 18747793 GSVIVG01011033001 2083970 2084886 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01011033001 2083970 2084886 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01011033001 2083970 2084886 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01011033001 2083970 2084886 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01011033001 2083970 2084886 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01011033001 2083970 2084886 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01011033001 2083970 2084886 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01011033001 2083970 2084886 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01016283001 5554339 5557189 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016471 vacuolar proton-transporting V-type ATPase complex A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01013402001 686115 690591 GO:0006397 mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01013402001 686115 690591 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01013402001 686115 690591 GO:0006397 mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01013402001 686115 690591 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01013402001 686115 690591 GO:0006397 mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01013402001 686115 690591 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01013402001 686115 690591 GO:0006397 mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013402001 686115 690591 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013402001 686115 690591 GO:0006397 mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. IEA Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters. IEA GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters GSVIVG01013402001 686115 690591 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters. IEA GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters GSVIVG01020159001 9674651 9688246 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020159001 9674651 9688246 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020159001 9674651 9688246 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008237 metallopeptidase activity GSVIVG01020159001 9674651 9688246 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008237 metallopeptidase activity GSVIVG01020159001 9674651 9688246 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01020159001 9674651 9688246 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01020159001 9674651 9688246 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01020159001 9674651 9688246 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01036236001 8378373 8446367 GSVIVG01027074001 18157107 18157214 GSVIVG01018427001 9134699 9135971 GSVIVG01003131001 7520653 7521279 GSVIVG01038590001 21644192 21676537 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01038590001 21644192 21676537 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end. IEA GO:0008408 3'-5' exonuclease activity GSVIVG01008822001 2477472 2479865 GSVIVG01011123001 1386834 1392941 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01001102001 22646709 22649537 GSVIVG01026747001 6121922 6123715 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01026747001 6121922 6123715 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01026747001 6121922 6123715 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026747001 6121922 6123715 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013729001 8121188 8123949 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01013729001 8121188 8123949 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01013729001 8121188 8123949 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01013729001 8121188 8123949 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031185001 1400771 1412990 GO:0006099 tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. IEA GO:0045239 tricarboxylic acid cycle enzyme complex Any of the heteromeric enzymes that act in the TCA cycle. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031185001 1400771 1412990 GO:0006106 fumarate metabolic process The chemical reactions and pathways involving fumarate, the anion of trans-1,2-ethenedicarboxylic acid, the diastereoisomer of maleate. It is a key intermediate in metabolism and is formed in the TCA cycle from succinate and converted into malate. IEA GO:0045239 tricarboxylic acid cycle enzyme complex Any of the heteromeric enzymes that act in the TCA cycle. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031185001 1400771 1412990 GO:0006099 tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. IEA GO:0045239 tricarboxylic acid cycle enzyme complex Any of the heteromeric enzymes that act in the TCA cycle. IEA Catalysis of the reaction: (S)-malate = fumarate + H2O. IEA GO:0004333 fumarate hydratase activity GSVIVG01031185001 1400771 1412990 GO:0006106 fumarate metabolic process The chemical reactions and pathways involving fumarate, the anion of trans-1,2-ethenedicarboxylic acid, the diastereoisomer of maleate. It is a key intermediate in metabolism and is formed in the TCA cycle from succinate and converted into malate. IEA GO:0045239 tricarboxylic acid cycle enzyme complex Any of the heteromeric enzymes that act in the TCA cycle. IEA Catalysis of the reaction: (S)-malate = fumarate + H2O. IEA GO:0004333 fumarate hydratase activity GSVIVG01031185001 1400771 1412990 GO:0006099 tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. IEA GO:0045239 tricarboxylic acid cycle enzyme complex Any of the heteromeric enzymes that act in the TCA cycle. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01031185001 1400771 1412990 GO:0006106 fumarate metabolic process The chemical reactions and pathways involving fumarate, the anion of trans-1,2-ethenedicarboxylic acid, the diastereoisomer of maleate. It is a key intermediate in metabolism and is formed in the TCA cycle from succinate and converted into malate. IEA GO:0045239 tricarboxylic acid cycle enzyme complex Any of the heteromeric enzymes that act in the TCA cycle. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01025325001 2011030 2017482 GSVIVG01000601001 6628696 6633992 GSVIVG01001992001 6129791 6131464 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01001992001 6129791 6131464 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01001530001 1051113 1056306 GSVIVG01018409001 9488712 9489868 GSVIVG01030775001 15733810 15761975 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01030775001 15733810 15761975 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01030775001 15733810 15761975 GO:0006438 valyl-tRNA aminoacylation The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01030775001 15733810 15761975 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01030775001 15733810 15761975 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01030775001 15733810 15761975 GO:0006438 valyl-tRNA aminoacylation The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01030775001 15733810 15761975 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val). IEA GO:0004832 valine-tRNA ligase activity GSVIVG01030775001 15733810 15761975 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val). IEA GO:0004832 valine-tRNA ligase activity GSVIVG01030775001 15733810 15761975 GO:0006438 valyl-tRNA aminoacylation The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val). IEA GO:0004832 valine-tRNA ligase activity GSVIVG01030775001 15733810 15761975 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030775001 15733810 15761975 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030775001 15733810 15761975 GO:0006438 valyl-tRNA aminoacylation The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028087001 3707261 3708787 GSVIVG01029570001 21409180 21419666 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01008668001 9172 13753 GSVIVG01013738001 8036641 8038012 GSVIVG01022505001 4059138 4073228 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01008344001 3086515 3092680 GSVIVG01008458001 1793568 1816622 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01005725001 21683215 21695773 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035560001 2304860 2312434 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01035560001 2304860 2312434 GO:0007049 cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01035560001 2304860 2312434 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01000973001 10810176 10813783 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01000973001 10810176 10813783 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003486001 10678663 10680046 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005267 potassium channel activity GSVIVG01028908001 17650000 17657367 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01010254001 18394884 18440368 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01010254001 18394884 18440368 GO:0006955 immune response Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01010254001 18394884 18440368 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01010254001 18394884 18440368 GO:0006955 immune response Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01010254001 18394884 18440368 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate, driving the unwinding of the DNA helix. IEA GO:0004003 ATP-dependent DNA helicase activity GSVIVG01010254001 18394884 18440368 GO:0006955 immune response Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate, driving the unwinding of the DNA helix. IEA GO:0004003 ATP-dependent DNA helicase activity GSVIVG01010254001 18394884 18440368 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010254001 18394884 18440368 GO:0006955 immune response Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010254001 18394884 18440368 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA The function of a family of chemotactic pro-inflammatory activation-inducible cytokines acting primarily upon hemopoietic cells in immunoregulatory processes; all chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. IEA GO:0008009 chemokine activity GSVIVG01010254001 18394884 18440368 GO:0006955 immune response Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA The function of a family of chemotactic pro-inflammatory activation-inducible cytokines acting primarily upon hemopoietic cells in immunoregulatory processes; all chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. IEA GO:0008009 chemokine activity GSVIVG01010254001 18394884 18440368 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01010254001 18394884 18440368 GO:0006955 immune response Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01010254001 18394884 18440368 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01010254001 18394884 18440368 GO:0006955 immune response Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01027158001 17367842 17369993 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01028463001 7953044 7979057 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01028463001 7953044 7979057 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01028463001 7953044 7979057 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01028463001 7953044 7979057 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026708001 5231083 5234771 Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01003495001 10743371 10744620 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01006027001 23286961 23298548 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032211001 21484833 21503527 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate. IEA GO:0004360 glutamine-fructose-6-phosphate transaminase (isomerizing) activity GSVIVG01032211001 21484833 21503527 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate. IEA GO:0004360 glutamine-fructose-6-phosphate transaminase (isomerizing) activity GSVIVG01032211001 21484833 21503527 GO:0016051 carbohydrate biosynthetic process The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate. IEA GO:0004360 glutamine-fructose-6-phosphate transaminase (isomerizing) activity GSVIVG01032211001 21484833 21503527 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01032211001 21484833 21503527 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01032211001 21484833 21503527 GO:0016051 carbohydrate biosynthetic process The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01013029001 9912738 9926343 GSVIVG01014482001 4309213 4314290 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014482001 4309213 4314290 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014482001 4309213 4314290 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014482001 4309213 4314290 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014482001 4309213 4314290 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014482001 4309213 4314290 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014482001 4309213 4314290 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014482001 4309213 4314290 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017050001 3786202 3789407 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01019193001 3728979 3734133 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01019193001 3728979 3734133 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01019193001 3728979 3734133 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019193001 3728979 3734133 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019193001 3728979 3734133 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01019193001 3728979 3734133 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01019193001 3728979 3734133 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01019193001 3728979 3734133 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01029373001 15635143 15638604 GSVIVG01009285001 6969510 6975251 GSVIVG01036454001 22232135 22243014 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036454001 22232135 22243014 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01033620001 19217894 19228661 GSVIVG01020008001 11680568 11687175 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0031461 cullin-RING ubiquitin ligase complex Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity. IEA Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. IEA GO:0016791 phosphatase activity GSVIVG01020008001 11680568 11687175 GO:0009405 pathogenesis The set of specific processes that generate the ability of an organism to cause disease in another. IEA GO:0031461 cullin-RING ubiquitin ligase complex Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity. IEA Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. IEA GO:0016791 phosphatase activity GSVIVG01020008001 11680568 11687175 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0031461 cullin-RING ubiquitin ligase complex Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity. IEA Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins. IEA GO:0031625 ubiquitin protein ligase binding GSVIVG01020008001 11680568 11687175 GO:0009405 pathogenesis The set of specific processes that generate the ability of an organism to cause disease in another. IEA GO:0031461 cullin-RING ubiquitin ligase complex Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity. IEA Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins. IEA GO:0031625 ubiquitin protein ligase binding GSVIVG01032624001 2104375 2110460 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of a calcium ion by a voltage-gated channel. IEA GO:0005245 voltage-gated calcium channel activity GSVIVG01017766001 3274389 3274837 GSVIVG01035642001 2917397 2920694 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01035642001 2917397 2920694 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01028882001 17827580 17830662 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01028882001 17827580 17830662 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01028882001 17827580 17830662 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01028882001 17827580 17830662 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01013868001 5694429 5703035 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01013868001 5694429 5703035 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01013868001 5694429 5703035 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01013868001 5694429 5703035 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01013868001 5694429 5703035 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01013868001 5694429 5703035 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01013868001 5694429 5703035 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01013868001 5694429 5703035 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01013868001 5694429 5703035 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01013868001 5694429 5703035 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01013868001 5694429 5703035 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01013868001 5694429 5703035 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01013868001 5694429 5703035 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013868001 5694429 5703035 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013868001 5694429 5703035 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013868001 5694429 5703035 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013868001 5694429 5703035 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013868001 5694429 5703035 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013868001 5694429 5703035 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01013868001 5694429 5703035 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01013868001 5694429 5703035 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01013868001 5694429 5703035 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01013868001 5694429 5703035 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01013868001 5694429 5703035 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01013868001 5694429 5703035 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate. IEA GO:0019001 guanyl nucleotide binding GSVIVG01013868001 5694429 5703035 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate. IEA GO:0019001 guanyl nucleotide binding GSVIVG01013868001 5694429 5703035 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate. IEA GO:0019001 guanyl nucleotide binding GSVIVG01013868001 5694429 5703035 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate. IEA GO:0019001 guanyl nucleotide binding GSVIVG01013868001 5694429 5703035 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate. IEA GO:0019001 guanyl nucleotide binding GSVIVG01013868001 5694429 5703035 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate. IEA GO:0019001 guanyl nucleotide binding GSVIVG01033879001 17064122 17068584 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01033879001 17064122 17068584 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01014147001 813603 825355 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014147001 813603 825355 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014147001 813603 825355 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014147001 813603 825355 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014147001 813603 825355 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031930001 5487805 5489892 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01031930001 5487805 5489892 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01031930001 5487805 5489892 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01031930001 5487805 5489892 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01027580001 15353606 15366406 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01027580001 15353606 15366406 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01027430001 16807997 16809403 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027430001 16807997 16809403 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a phosphate group (acceptor). IEA GO:0016776 phosphotransferase activity, phosphate group as acceptor GSVIVG01027430001 16807997 16809403 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Catalysis of the reaction: ATP + nucleoside monophosphate = ADP + nucleoside diphosphate. IEA GO:0019201 nucleotide kinase activity GSVIVG01027430001 16807997 16809403 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate. IEA GO:0019205 nucleobase, nucleoside, nucleotide kinase activity GSVIVG01009876001 12004532 12013907 GO:0000103 sulfate assimilation The pathways by which inorganic sulfate is processed and incorporated into sulfated compounds. IEA Catalysis of the reaction: ATP + sulfate = diphosphate + adenylylsulfate. IEA GO:0004781 sulfate adenylyltransferase (ATP) activity GSVIVG01019542001 1464114 1471910 GSVIVG01020852001 1094088 1099502 GSVIVG01017108001 4206613 4234687 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01017108001 4206613 4234687 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate, driving the unwinding of the DNA helix. IEA GO:0004003 ATP-dependent DNA helicase activity GSVIVG01017108001 4206613 4234687 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017108001 4206613 4234687 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01017108001 4206613 4234687 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. IEA GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GSVIVG01015721001 16344079 16360673 GSVIVG01010470001 20854747 20855013 GSVIVG01011584001 6248926 6263935 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033300001 21708517 21711250 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01009522001 9040141 9044410 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0000808 origin recognition complex A multisubunit complex that is located at the replication origins of a chromosome. IEA GSVIVG01009522001 9040141 9044410 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01029411001 16771613 16773967 GO:0009306 protein secretion The controlled release of proteins from a cell or group of cells. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01029411001 16771613 16773967 GO:0009306 protein secretion The controlled release of proteins from a cell or group of cells. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01029411001 16771613 16773967 GO:0009306 protein secretion The controlled release of proteins from a cell or group of cells. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01029411001 16771613 16773967 GO:0009664 plant-type cell wall organization A process that results in the assembly and arrangement of constituent parts of the cellulose and pectin-containing cell wall, or in the disassembly of the cellulose and pectin-containing cell wall. This process is carried out at the cellular level. An example of this process is found in Arabidopsis thaliana. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01029411001 16771613 16773967 GO:0009664 plant-type cell wall organization A process that results in the assembly and arrangement of constituent parts of the cellulose and pectin-containing cell wall, or in the disassembly of the cellulose and pectin-containing cell wall. This process is carried out at the cellular level. An example of this process is found in Arabidopsis thaliana. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01029411001 16771613 16773967 GO:0009664 plant-type cell wall organization A process that results in the assembly and arrangement of constituent parts of the cellulose and pectin-containing cell wall, or in the disassembly of the cellulose and pectin-containing cell wall. This process is carried out at the cellular level. An example of this process is found in Arabidopsis thaliana. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01022331001 18550287 18554860 GSVIVG01021955001 5094731 5100392 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01021955001 5094731 5100392 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01021955001 5094731 5100392 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021955001 5094731 5100392 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021955001 5094731 5100392 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01021955001 5094731 5100392 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01000827001 2637237 2644750 GSVIVG01036804001 22323046 22329438 GSVIVG01024552001 8895096 8916273 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01024552001 8895096 8916273 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01024552001 8895096 8916273 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024552001 8895096 8916273 Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01030616001 7190475 7200729 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01030616001 7190475 7200729 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01030616001 7190475 7200729 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01030616001 7190475 7200729 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01030097001 9792187 9794439 GSVIVG01009715001 10701653 10708870 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01009715001 10701653 10708870 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01009715001 10701653 10708870 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01009715001 10701653 10708870 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01009715001 10701653 10708870 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023222001 20968699 20973040 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023222001 20968699 20973040 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023222001 20968699 20973040 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01023222001 20968699 20973040 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01023222001 20968699 20973040 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023222001 20968699 20973040 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031783001 4327743 4329320 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with neuropeptide Y to initiate a change in cell activity. IEA GO:0004983 neuropeptide Y receptor activity GSVIVG01038789001 963629 965631 GSVIVG01033932001 16617003 16618313 GSVIVG01028466001 8009516 8012777 GSVIVG01027186001 17173556 17175511 GSVIVG01014349001 2889428 2899404 Catalysis of the transfer of a nucleotidyl group to a reactant. IEA GO:0016779 nucleotidyltransferase activity GSVIVG01013669001 2289267 2289595 GSVIVG01025854001 11206189 11210325 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin. IEA GO:0004221 ubiquitin thiolesterase activity GSVIVG01000212001 16125314 16127833 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01000212001 16125314 16127833 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01000212001 16125314 16127833 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01000212001 16125314 16127833 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01000212001 16125314 16127833 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001870001 357778 360792 GSVIVG01020689001 3080476 3085126 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01020689001 3080476 3085126 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01020689001 3080476 3085126 GO:0009082 branched chain family amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01020689001 3080476 3085126 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01020689001 3080476 3085126 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+. IEA GO:0004455 ketol-acid reductoisomerase activity GSVIVG01020689001 3080476 3085126 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the reaction: (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+. IEA GO:0004455 ketol-acid reductoisomerase activity GSVIVG01020689001 3080476 3085126 GO:0009082 branched chain family amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. IEA Catalysis of the reaction: (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+. IEA GO:0004455 ketol-acid reductoisomerase activity GSVIVG01020689001 3080476 3085126 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+. IEA GO:0004455 ketol-acid reductoisomerase activity GSVIVG01020689001 3080476 3085126 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01020689001 3080476 3085126 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01020689001 3080476 3085126 GO:0009082 branched chain family amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01020689001 3080476 3085126 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01020689001 3080476 3085126 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01020689001 3080476 3085126 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01020689001 3080476 3085126 GO:0009082 branched chain family amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01020689001 3080476 3085126 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01020689001 3080476 3085126 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01020689001 3080476 3085126 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01020689001 3080476 3085126 GO:0009082 branched chain family amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01020689001 3080476 3085126 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01014261001 2082214 2096660 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030127 COPII vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014261001 2082214 2096660 GO:0006888 ER to Golgi vesicle-mediated transport The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi. IEA GO:0030127 COPII vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014261001 2082214 2096660 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030127 COPII vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01014261001 2082214 2096660 GO:0006888 ER to Golgi vesicle-mediated transport The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi. IEA GO:0030127 COPII vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01030544001 6616341 6620488 GO:0006909 phagocytosis The process whereby phagocytes engulf external particulate material. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles. IEA GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA GSVIVG01008460001 1773397 1775196 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01008460001 1773397 1775196 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01012850001 6086975 6132551 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GSVIVG01032863001 140563 140652 GSVIVG01012401001 492998 508241 GSVIVG01020363001 20534127 20535179 GSVIVG01035854001 4898929 4902166 GSVIVG01030667001 13205171 13233138 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0008076 voltage-gated potassium channel complex A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01030667001 13205171 13233138 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01030667001 13205171 13233138 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01030667001 13205171 13233138 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0008076 voltage-gated potassium channel complex A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01030667001 13205171 13233138 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01030667001 13205171 13233138 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01030667001 13205171 13233138 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0008076 voltage-gated potassium channel complex A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01030667001 13205171 13233138 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01030667001 13205171 13233138 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01030667001 13205171 13233138 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0008076 voltage-gated potassium channel complex A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01030667001 13205171 13233138 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01030667001 13205171 13233138 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01030667001 13205171 13233138 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0008076 voltage-gated potassium channel complex A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01030667001 13205171 13233138 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01030667001 13205171 13233138 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01030667001 13205171 13233138 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0008076 voltage-gated potassium channel complex A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01030667001 13205171 13233138 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01030667001 13205171 13233138 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01030667001 13205171 13233138 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0008076 voltage-gated potassium channel complex A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01030667001 13205171 13233138 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01030667001 13205171 13233138 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01030667001 13205171 13233138 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0008076 voltage-gated potassium channel complex A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01030667001 13205171 13233138 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01030667001 13205171 13233138 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01009722001 10789626 10789688 GSVIVG01029300001 17351654 17361828 GSVIVG01006730001 27812452 27816699 GSVIVG01006903001 29002053 29005128 GSVIVG01013118001 8071720 8071824 GSVIVG01018317001 11181032 11185013 GSVIVG01033100001 25721018 25723110 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01033100001 25721018 25723110 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01033100001 25721018 25723110 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01033100001 25721018 25723110 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01024943001 5864811 5869321 GO:0005923 tight junction An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01024943001 5864811 5869321 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01004676001 39576038 39577455 GSVIVG01017171001 4932765 4957804 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01017171001 4932765 4957804 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). IEA GO:0016769 transferase activity, transferring nitrogenous groups GSVIVG01017171001 4932765 4957804 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + methylthioadenosine. IEA GO:0016847 1-aminocyclopropane-1-carboxylate synthase activity GSVIVG01017171001 4932765 4957804 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01031171001 1535948 1540863 GSVIVG01026872001 19735124 19736662 GSVIVG01012504001 104789 111420 GSVIVG01001315001 5248528 5250185 GSVIVG01004826001 5475216 5475660 GSVIVG01011067001 1850826 1852533 GSVIVG01020739001 2452844 2458700 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01020739001 2452844 2458700 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01020739001 2452844 2458700 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate. IEA GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity GSVIVG01020739001 2452844 2458700 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate. IEA GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity GSVIVG01020739001 2452844 2458700 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. IEA GO:0008483 transaminase activity GSVIVG01020739001 2452844 2458700 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. IEA GO:0008483 transaminase activity GSVIVG01020739001 2452844 2458700 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01020739001 2452844 2458700 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01020739001 2452844 2458700 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). IEA GO:0016769 transferase activity, transferring nitrogenous groups GSVIVG01020739001 2452844 2458700 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). IEA GO:0016769 transferase activity, transferring nitrogenous groups GSVIVG01020739001 2452844 2458700 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01020739001 2452844 2458700 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01022465001 3372322 3373788 Stops, prevents or reduces the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a phospholipid. IEA GO:0004859 phospholipase inhibitor activity GSVIVG01022465001 3372322 3373788 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01022465001 3372322 3373788 Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium. IEA GO:0005544 calcium-dependent phospholipid binding GSVIVG01022465001 3372322 3373788 Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton). IEA GO:0008092 cytoskeletal protein binding GSVIVG01038280001 24942992 24946222 GSVIVG01005618001 40930632 40931552 Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor). IEA GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups GSVIVG01032154001 22070604 22075721 Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01031470001 18191459 18230633 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m). IEA GO:0003910 DNA ligase (ATP) activity GSVIVG01031470001 18191459 18230633 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m). IEA GO:0003910 DNA ligase (ATP) activity GSVIVG01031470001 18191459 18230633 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m). IEA GO:0003910 DNA ligase (ATP) activity GSVIVG01031470001 18191459 18230633 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031470001 18191459 18230633 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031470001 18191459 18230633 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009723001 10790010 10791984 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01000072001 3217518 3218665 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026565001 21752767 21752934 GSVIVG01011324001 8515201 8526539 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01024903001 6151710 6153607 GSVIVG01023515001 10550911 10551404 GSVIVG01038150001 23901798 23902791 GSVIVG01018442001 15057516 15063943 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01023095001 15389715 15393519 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01024550001 8929928 8936251 GO:0006413 translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. IEA Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. IEA GO:0003743 translation initiation factor activity GSVIVG01035922001 5890296 5930252 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017903001 4502463 4509891 GSVIVG01008356001 2907492 2909885 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01008356001 2907492 2909885 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01008356001 2907492 2909885 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008356001 2907492 2909885 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018681001 11185041 11218538 GSVIVG01015603001 5503361 5512244 GO:0048268 clathrin coat assembly The process by which clathrin triskelia are assembled into the ordered structure known as a clathrin cage. IEA GO:0030118 clathrin coat A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes. IEA Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester. IEA GO:0005543 phospholipid binding GSVIVG01015603001 5503361 5512244 GO:0048268 clathrin coat assembly The process by which clathrin triskelia are assembled into the ordered structure known as a clathrin cage. IEA GO:0030118 clathrin coat A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes. IEA Interacting selectively and non-covalently with phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. IEA GO:0005545 phosphatidylinositol binding GSVIVG01015603001 5503361 5512244 GO:0048268 clathrin coat assembly The process by which clathrin triskelia are assembled into the ordered structure known as a clathrin cage. IEA GO:0030118 clathrin coat A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes. IEA Interacting selectively and non-covalently with a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles. IEA GO:0030276 clathrin binding GSVIVG01024430001 2482168 2483049 GSVIVG01034385001 16961415 16964654 GO:0008360 regulation of cell shape Any process that modulates the surface configuration of a cell. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034385001 16961415 16964654 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034385001 16961415 16964654 GO:0009252 peptidoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034385001 16961415 16964654 GO:0009273 peptidoglycan-based cell wall biogenesis The chemical reactions and pathways resulting in the formation of the peptidoglycan-based cell wall. An example of this process is found in Escherichia coli. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034385001 16961415 16964654 GO:0051301 cell division The process resulting in the physical partitioning and separation of a cell into daughter cells. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034385001 16961415 16964654 GO:0008360 regulation of cell shape Any process that modulates the surface configuration of a cell. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptanedioate + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanyl-D-alanine. IEA GO:0008766 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity GSVIVG01034385001 16961415 16964654 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptanedioate + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanyl-D-alanine. IEA GO:0008766 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity GSVIVG01034385001 16961415 16964654 GO:0009252 peptidoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptanedioate + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanyl-D-alanine. IEA GO:0008766 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity GSVIVG01034385001 16961415 16964654 GO:0009273 peptidoglycan-based cell wall biogenesis The chemical reactions and pathways resulting in the formation of the peptidoglycan-based cell wall. An example of this process is found in Escherichia coli. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptanedioate + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanyl-D-alanine. IEA GO:0008766 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity GSVIVG01034385001 16961415 16964654 GO:0051301 cell division The process resulting in the physical partitioning and separation of a cell into daughter cells. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptanedioate + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanyl-D-alanine. IEA GO:0008766 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity GSVIVG01034385001 16961415 16964654 GO:0008360 regulation of cell shape Any process that modulates the surface configuration of a cell. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01034385001 16961415 16964654 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01034385001 16961415 16964654 GO:0009252 peptidoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01034385001 16961415 16964654 GO:0009273 peptidoglycan-based cell wall biogenesis The chemical reactions and pathways resulting in the formation of the peptidoglycan-based cell wall. An example of this process is found in Escherichia coli. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01034385001 16961415 16964654 GO:0051301 cell division The process resulting in the physical partitioning and separation of a cell into daughter cells. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01005190001 19002942 19011585 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051539 4 iron, 4 sulfur cluster binding GSVIVG01003611001 11230514 11245436 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005945 6-phosphofructokinase complex A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known. IEA Catalysis of the reaction: ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate. IEA GO:0003872 6-phosphofructokinase activity GSVIVG01003611001 11230514 11245436 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005945 6-phosphofructokinase complex A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030751001 15276179 15276645 GSVIVG01023662001 8704228 8705144 GSVIVG01030509001 6322317 6327193 GO:0016311 dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. IEA Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. IEA GO:0004725 protein tyrosine phosphatase activity GSVIVG01030509001 6322317 6327193 GO:0016311 dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. IEA Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. IEA GO:0016791 phosphatase activity GSVIVG01028411001 7299138 7313963 GO:0016568 chromatin modification The alteration of DNA or protein in chromatin, which may result in changing the chromatin structure. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01028411001 7299138 7313963 GO:0016568 chromatin modification The alteration of DNA or protein in chromatin, which may result in changing the chromatin structure. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives. IEA GO:0018024 histone-lysine N-methyltransferase activity GSVIVG01003541001 226257 227252 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003541001 226257 227252 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01003541001 226257 227252 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01003109001 7319224 7320320 GSVIVG01013908001 6652258 6653408 GSVIVG01025974001 26421126 26423185 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01025974001 26421126 26423185 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01025974001 26421126 26423185 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01025974001 26421126 26423185 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025974001 26421126 26423185 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01025974001 26421126 26423185 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01021864001 6365231 6366116 GSVIVG01013683001 2575375 2575680 GSVIVG01015115001 1147062 1150768 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GSVIVG01035972001 6657070 6658020 Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01035972001 6657070 6658020 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01009402001 8002639 8020766 GSVIVG01038037001 16593568 16595273 GSVIVG01037619001 6288425 6294095 GSVIVG01038462001 9711212 9711365 GSVIVG01033444001 20642407 20644673 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01033444001 20642407 20644673 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01030370001 5058188 5059816 GSVIVG01021910001 5731154 5734790 GO:0009734 auxin mediated signaling pathway The series of molecular signals generated in response to detection of auxin. ISS Interacting selectively and non-covalently with inositol hexakisphosphate. ISS GO:0000822 inositol hexakisphosphate binding GSVIVG01035052001 1198293 1203246 GSVIVG01012749001 24081720 24082963 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01012749001 24081720 24082963 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01012749001 24081720 24082963 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01012749001 24081720 24082963 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01012749001 24081720 24082963 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012749001 24081720 24082963 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012749001 24081720 24082963 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012749001 24081720 24082963 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012749001 24081720 24082963 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012749001 24081720 24082963 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012749001 24081720 24082963 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012749001 24081720 24082963 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020358001 20596644 20609026 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020358001 20596644 20609026 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020358001 20596644 20609026 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020358001 20596644 20609026 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037894001 6571801 6592129 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01037894001 6571801 6592129 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01037894001 6571801 6592129 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01037894001 6571801 6592129 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01037894001 6571801 6592129 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01037894001 6571801 6592129 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01037894001 6571801 6592129 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01037894001 6571801 6592129 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01037894001 6571801 6592129 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01037894001 6571801 6592129 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01037894001 6571801 6592129 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01037894001 6571801 6592129 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01026131001 12713642 12717484 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: 3-alpha(S)-strictosidine = tryptamine + secologanin. IEA GO:0016844 strictosidine synthase activity GSVIVG01004407001 38425502 38428251 GSVIVG01014604001 5530863 5545741 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001039001 6746751 6749359 GSVIVG01035780001 4227019 4234518 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01035780001 4227019 4234518 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01035780001 4227019 4234518 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01035780001 4227019 4234518 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035780001 4227019 4234518 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01035780001 4227019 4234518 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01027805001 7973215 7973394 GSVIVG01004078001 14613091 14619288 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01004078001 14613091 14619288 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01004078001 14613091 14619288 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01004078001 14613091 14619288 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01018365001 10328819 10349872 GO:0016575 histone deacetylation The modification of histones by removal of acetyl groups. IEA Catalysis of the hydrolysis of acetyl groups from histones, proteins complexed to DNA in chromatin and chromosomes. IEA GO:0004407 histone deacetylase activity GSVIVG01018365001 10328819 10349872 GO:0016575 histone deacetylation The modification of histones by removal of acetyl groups. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01030842001 17405673 17407309 GSVIVG01031787001 4359739 4367121 GSVIVG01030735001 14806792 14808361 GSVIVG01003718001 7344796 7346208 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003718001 7344796 7346208 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003718001 7344796 7346208 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01003718001 7344796 7346208 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01003718001 7344796 7346208 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01003718001 7344796 7346208 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01003718001 7344796 7346208 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01003718001 7344796 7346208 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01020656001 3376588 3379249 GSVIVG01021832001 6757809 6760390 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01032402001 26972211 26977345 GO:0051260 protein homooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01032402001 26972211 26977345 GO:0051260 protein homooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01032402001 26972211 26977345 GO:0051260 protein homooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01024094001 1168819 1189934 GSVIVG01016036001 17694868 17735303 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01016036001 17694868 17735303 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01038365001 13702438 13705184 GSVIVG01014332001 2720597 2723239 GSVIVG01035937001 6145587 6149666 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031378001 19347375 19360240 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01031378001 19347375 19360240 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031378001 19347375 19360240 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01031378001 19347375 19360240 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01017802001 3574216 3577147 GSVIVG01036864001 18524902 18525066 GSVIVG01015189001 1658052 1661058 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01015189001 1658052 1661058 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01015189001 1658052 1661058 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01015189001 1658052 1661058 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01019118001 16577018 16579760 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01019118001 16577018 16579760 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01018407001 9519257 9531579 GSVIVG01031908001 5305834 5311431 GO:0019288 isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate by the mevalonate-independent pathway. Isopentenyl diphosphate (IPP) is the fundamental unit in isoprenoid biosynthesis and is biosynthesized from pyruvate and glyceraldehyde 3-phosphate via intermediates, including 1-deoxy-D-xylulose 5-phosphate. IEA GSVIVG01031908001 5305834 5311431 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GSVIVG01018976001 18184769 18192254 GO:0006099 tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01018976001 18184769 18192254 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01018976001 18184769 18192254 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01018976001 18184769 18192254 GO:0006099 tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01018976001 18184769 18192254 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01018976001 18184769 18192254 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01018976001 18184769 18192254 GO:0006099 tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GSVIVG01018976001 18184769 18192254 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GSVIVG01018976001 18184769 18192254 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GSVIVG01018976001 18184769 18192254 GO:0006099 tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01018976001 18184769 18192254 GO:0022900 electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01018976001 18184769 18192254 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01028446001 7731375 7733606 GSVIVG01018683001 11166128 11166866 GSVIVG01020920001 17144368 17217606 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025201001 3373992 3381809 GSVIVG01033136001 8254615 8256154 GSVIVG01003808001 315341 323662 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01003808001 315341 323662 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016171001 7072593 7075034 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009413001 8157249 8159843 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01009413001 8157249 8159843 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01009413001 8157249 8159843 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01009413001 8157249 8159843 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01009413001 8157249 8159843 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01009413001 8157249 8159843 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01009413001 8157249 8159843 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009413001 8157249 8159843 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009413001 8157249 8159843 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01009413001 8157249 8159843 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01017458001 8759317 8780562 GSVIVG01032715001 1304494 1306176 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01032715001 1304494 1306176 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01032715001 1304494 1306176 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01032715001 1304494 1306176 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01010336001 19586824 19601973 GSVIVG01023597001 7809647 7827580 GSVIVG01004727001 15562752 15568387 GO:0006298 mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01004727001 15562752 15568387 GO:0006298 mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. IEA Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches. IEA GO:0030983 mismatched DNA binding GSVIVG01009669001 10333851 10334042 GSVIVG01000312001 2949698 2949940 GSVIVG01037695001 6966540 7003205 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01037695001 6966540 7003205 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01037695001 6966540 7003205 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01010126001 15902530 15907102 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01000052001 3097937 3109879 GSVIVG01032440001 27420417 27429407 GSVIVG01001601001 18301048 18305241 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01001601001 18301048 18305241 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033738001 18222784 18224352 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01012719001 947083 951306 GSVIVG01013202001 6784848 6786547 GSVIVG01007038001 29821520 29831478 GSVIVG01015580001 5181377 5199356 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GSVIVG01024580001 8658619 8659182 GSVIVG01035151001 11536641 11537644 GSVIVG01016322001 5116237 5120866 Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01017992001 5316262 5317685 GSVIVG01013276001 5757586 5775765 GSVIVG01011126001 1364934 1370151 GSVIVG01028566001 9937352 9940599 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027612001 15058524 15060553 GSVIVG01009450001 8476614 8478580 GSVIVG01001419001 18930309 18934653 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001419001 18930309 18934653 Catalysis of the elimination of H2S or substituted H2S. IEA GO:0016846 carbon-sulfur lyase activity GSVIVG01001419001 18930309 18934653 Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01022762001 16237263 16239318 GO:0001539 ciliary or flagellar motility Cell motility due to movement of cilia or flagella. IEA GO:0009428 bacterial-type flagellum basal body, distal rod, P ring One of the rings of the flagellar basal body; anchors the basal body to the peptidoglycan layer. Examples of this component are found in bacteria. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01022762001 16237263 16239318 GO:0001539 ciliary or flagellar motility Cell motility due to movement of cilia or flagella. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01022762001 16237263 16239318 GO:0001539 ciliary or flagellar motility Cell motility due to movement of cilia or flagella. IEA GO:0009428 bacterial-type flagellum basal body, distal rod, P ring One of the rings of the flagellar basal body; anchors the basal body to the peptidoglycan layer. Examples of this component are found in bacteria. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01022762001 16237263 16239318 GO:0001539 ciliary or flagellar motility Cell motility due to movement of cilia or flagella. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01000265001 20715350 20721724 GSVIVG01017278001 6280602 6282700 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA GSVIVG01017278001 6280602 6282700 GO:0006888 ER to Golgi vesicle-mediated transport The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA GSVIVG01034388001 16950683 16951261 GSVIVG01007141001 30378443 30381143 GO:0006298 mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. IEA GO:0004969 histamine receptor activity GSVIVG01007141001 30378443 30381143 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. IEA GO:0004969 histamine receptor activity GSVIVG01007141001 30378443 30381143 GO:0006298 mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007141001 30378443 30381143 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007141001 30378443 30381143 GO:0006298 mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches. IEA GO:0030983 mismatched DNA binding GSVIVG01007141001 30378443 30381143 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches. IEA GO:0030983 mismatched DNA binding GSVIVG01019130001 16418701 16420923 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032513001 28010248 28013622 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01032513001 28010248 28013622 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01032513001 28010248 28013622 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01032513001 28010248 28013622 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01014353001 2950156 2950869 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005875 microtubule associated complex Any multimeric complex connected to a microtubule. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01035955001 6428660 6430028 GSVIVG01004589001 39141864 39145650 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01004589001 39141864 39145650 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01002124001 33079930 33081827 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion. IEA GO:0004806 triglyceride lipase activity GSVIVG01009974001 12964008 12971832 GO:0006546 glycine catabolic process The chemical reactions and pathways resulting in the breakdown of glycine, aminoethanoic acid. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA GSVIVG01009974001 12964008 12971832 GO:0006546 glycine catabolic process The chemical reactions and pathways resulting in the breakdown of glycine, aminoethanoic acid. IEA GO:0005960 glycine cleavage complex A protein complex that catalyzes the reversible oxidation of glycine. In E. coli, it has four components: dihydrolipoamide dehydrogenase, glycine dehydrogenase (decarboxylating), lipoyl-GcvH-protein and aminomethyltransferase, also known as L, P, H, and T. IEA GSVIVG01038381001 11503385 11514228 GSVIVG01004719001 15495019 15503835 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01004719001 15495019 15503835 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01004719001 15495019 15503835 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain. IEA GO:0004177 aminopeptidase activity GSVIVG01004719001 15495019 15503835 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain. IEA GO:0004177 aminopeptidase activity GSVIVG01015161001 1465690 1469245 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01008489001 1415291 1419190 GSVIVG01011487001 29993042 29998094 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01011581001 6286213 6286623 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01013753001 7941242 7941972 GSVIVG01012864001 6334483 6339364 GO:0015833 peptide transport The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012864001 6334483 6339364 GO:0015833 peptide transport The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of, within or between cells. IEA GO:0015197 peptide transporter activity GSVIVG01002389001 34542636 34545889 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01002389001 34542636 34545889 GO:0006970 response to osmotic stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01002389001 34542636 34545889 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01002389001 34542636 34545889 GO:0006970 response to osmotic stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01002389001 34542636 34545889 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01002389001 34542636 34545889 GO:0006970 response to osmotic stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01002389001 34542636 34545889 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01002389001 34542636 34545889 GO:0006970 response to osmotic stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038390001 11624929 11625510 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01038390001 11624929 11625510 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01017460001 8787617 8788322 GSVIVG01036381001 4445368 4460308 GO:0006680 glucosylceramide catabolic process The chemical reactions and pathways resulting in the breakdown of glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01036381001 4445368 4460308 GO:0006680 glucosylceramide catabolic process The chemical reactions and pathways resulting in the breakdown of glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine. IEA GO:0004348 glucosylceramidase activity GSVIVG01035980001 6768477 6777086 GO:0016070 RNA metabolic process The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035980001 6768477 6777086 GO:0016070 RNA metabolic process The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033901001 16868274 16872881 GSVIVG01013260001 6126813 6130313 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01009020001 4332857 4337515 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01009020001 4332857 4337515 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01023101001 22584326 22592055 GO:0008219 cell death A biological process that results in permanent cessation of all vital functions of a cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01011943001 2770673 2771827 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01016224001 6307458 6335135 GO:0006904 vesicle docking involved in exocytosis The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis. IEA GSVIVG01016224001 6307458 6335135 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GSVIVG01028350001 6475228 6478267 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01009090001 4966013 4967469 Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01009090001 4966013 4967469 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01028745001 19214734 19218905 GSVIVG01023915001 2513557 2515422 GSVIVG01013448001 393144 395658 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01013448001 393144 395658 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01013448001 393144 395658 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01013448001 393144 395658 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01013448001 393144 395658 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01013448001 393144 395658 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01013448001 393144 395658 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01013448001 393144 395658 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01003935001 8106611 8113787 GO:0046907 intracellular transport The directed movement of substances within a cell. IEA GSVIVG01024259001 283914 286654 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01014960001 12999415 13001085 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. IEA GO:0004364 glutathione transferase activity GSVIVG01009719001 10756946 10762561 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01009719001 10756946 10762561 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01009719001 10756946 10762561 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01009719001 10756946 10762561 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01037698001 7053771 7059043 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01037698001 7053771 7059043 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with double-stranded RNA. IEA GO:0003725 double-stranded RNA binding GSVIVG01037698001 7053771 7059043 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt. IEA GO:0004525 ribonuclease III activity GSVIVG01027046001 18382717 18384133 GSVIVG01022893001 18218347 18222206 GSVIVG01016687001 374414 376097 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of a lipid or phospholipid. IEA GO:0016298 lipase activity GSVIVG01016687001 374414 376097 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01004061001 598733 608049 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01004061001 598733 608049 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01004061001 598733 608049 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01004061001 598733 608049 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014849001 10531060 10542440 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01024343001 1209112 1210433 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024343001 1209112 1210433 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024343001 1209112 1210433 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024343001 1209112 1210433 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024343001 1209112 1210433 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024343001 1209112 1210433 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01010905001 15922201 15922959 GSVIVG01007995001 6825921 6827723 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01022277001 18105373 18106928 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01022277001 18105373 18106928 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01022277001 18105373 18106928 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01022277001 18105373 18106928 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01022277001 18105373 18106928 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01022277001 18105373 18106928 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01026917001 19416086 19416211 GSVIVG01020622001 3680486 3682488 GSVIVG01005064001 17815133 17817164 GSVIVG01023806001 3334416 3347343 GSVIVG01024285001 541615 543666 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. IEA GO:0004364 glutathione transferase activity GSVIVG01028192001 4522998 4525468 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01028192001 4522998 4525468 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028192001 4522998 4525468 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity. IEA GO:0004721 phosphoprotein phosphatase activity GSVIVG01028192001 4522998 4525468 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. IEA GO:0004722 protein serine/threonine phosphatase activity GSVIVG01028192001 4522998 4525468 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01028192001 4522998 4525468 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01013109001 8203533 8211263 GO:0032012 regulation of ARF protein signal transduction Any process that modulates the frequency, rate or extent of ARF protein signal transduction. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Stimulates the exchange of guanyl nucleotides associated with the GTPase ARF. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. IEA GO:0005086 ARF guanyl-nucleotide exchange factor activity GSVIVG01011513001 30211655 30212637 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0009317 acetyl-CoA carboxylase complex A protein complex that catalyzes the first step in long-chain fatty acid biosynthesis. For example, in E. coli the complex is heterohexameric and composed of biotin carbonyl carrier protein, biotin carboxylase and the acetate CoA-transferase complex. IEA Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA. IEA GO:0003989 acetyl-CoA carboxylase activity GSVIVG01011513001 30211655 30212637 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0009317 acetyl-CoA carboxylase complex A protein complex that catalyzes the first step in long-chain fatty acid biosynthesis. For example, in E. coli the complex is heterohexameric and composed of biotin carbonyl carrier protein, biotin carboxylase and the acetate CoA-transferase complex. IEA Interacting selectively and non-covalently with biotin (cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid), the (+) enantiomer of which is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions. IEA GO:0009374 biotin binding GSVIVG01012163001 930401 945147 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01012163001 930401 945147 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01012163001 930401 945147 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01005301001 20415278 20418002 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01008036001 6427646 6432407 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01008036001 6427646 6432407 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01008036001 6427646 6432407 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01008036001 6427646 6432407 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032438001 27413773 27415292 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01032438001 27413773 27415292 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds. IEA GO:0015035 protein disulfide oxidoreductase activity GSVIVG01007048001 29866833 29873706 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01007048001 29866833 29873706 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01021779001 7536191 7537704 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01021779001 7536191 7537704 GO:0009734 auxin mediated signaling pathway The series of molecular signals generated in response to detection of auxin. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01021779001 7536191 7537704 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01036890001 18145732 18146910 GSVIVG01013205001 6743161 6747172 GSVIVG01013606001 1228347 1229249 GSVIVG01031739001 3947671 3979555 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01018900001 18807503 18814040 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01023094001 15441858 15443172 GSVIVG01030579001 6864694 6866746 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01030579001 6864694 6866746 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01030579001 6864694 6866746 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01030579001 6864694 6866746 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01023605001 7907103 7909275 GSVIVG01019599001 1842259 1843381 GSVIVG01019955001 12408985 12410170 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009654 oxygen evolving complex A complex, composed of a cluster of manganese, calcium and chloride ions bound to extrinsic proteins, that catalyzes the splitting of water to O2 and 4 H+. In cyanobacteria there are five extrinsic proteins in OEC (PsbO, PsbP-like, PsbQ-like, PsbU and PsbV), while in plants there are only three (PsbO, PsbP and PsbQ). IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01019955001 12408985 12410170 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0019898 extrinsic to membrane Loosely bound to one surface of a membrane, but not integrated into the hydrophobic region. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01029050001 11463635 11464220 GSVIVG01009796001 11311313 11316066 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004197 cysteine-type endopeptidase activity GSVIVG01009796001 11311313 11316066 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01022068001 16327745 16331096 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01022068001 16327745 16331096 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01022068001 16327745 16331096 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01022068001 16327745 16331096 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA Catalysis of the reaction: tRNA-uracil + acceptor = tRNA-dihydrouridine + reduced acceptor. IEA GO:0017150 tRNA dihydrouridine synthase activity GSVIVG01022068001 16327745 16331096 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: tRNA-uracil + acceptor = tRNA-dihydrouridine + reduced acceptor. IEA GO:0017150 tRNA dihydrouridine synthase activity GSVIVG01022068001 16327745 16331096 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: tRNA-uracil + acceptor = tRNA-dihydrouridine + reduced acceptor. IEA GO:0017150 tRNA dihydrouridine synthase activity GSVIVG01022068001 16327745 16331096 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01022068001 16327745 16331096 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01022068001 16327745 16331096 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01035337001 595339 601589 GSVIVG01015028001 555170 558424 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01015028001 555170 558424 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01015028001 555170 558424 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01015028001 555170 558424 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01015028001 555170 558424 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01015028001 555170 558424 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01015028001 555170 558424 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01015028001 555170 558424 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01018903001 18773456 18779766 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01012495001 13917484 13917951 GSVIVG01007062001 29948077 29951552 GSVIVG01003605001 11196398 11198807 Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01037085001 29309060 29310270 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01015564001 4969413 4976709 GSVIVG01017561001 10565805 10568023 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01017561001 10565805 10568023 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01017561001 10565805 10568023 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01017561001 10565805 10568023 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01004930001 21582290 21584461 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01018765001 20094625 20105285 GSVIVG01028303001 5913709 5917774 GSVIVG01012105001 1422452 1425224 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01034807001 21898413 21898723 GSVIVG01010631001 15813713 15814830 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01010631001 15813713 15814830 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01003772001 12523780 12527241 GSVIVG01033714001 18394970 18396458 GSVIVG01037610001 6231410 6232754 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01037610001 6231410 6232754 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01037610001 6231410 6232754 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01037610001 6231410 6232754 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012457001 1145137 1152227 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function that links a sequence-specific transcription factor to the core RNA polymerase II complex but does not bind DNA itself. IEA GO:0003712 transcription cofactor activity GSVIVG01012457001 1145137 1152227 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01024966001 5630347 5630765 GSVIVG01016895001 2357241 2360595 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01016895001 2357241 2360595 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01028323001 6156298 6157832 GSVIVG01017339001 6876585 6878816 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01017339001 6876585 6878816 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01017339001 6876585 6878816 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water. IEA GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water GSVIVG01017339001 6876585 6878816 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water. IEA GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water GSVIVG01012659001 402298 411748 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Catalysis of the reaction: malonyl-CoA = acetyl-CoA + CO2. IEA GO:0050080 malonyl-CoA decarboxylase activity GSVIVG01019893001 4287650 4290952 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019893001 4287650 4290952 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019893001 4287650 4290952 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019893001 4287650 4290952 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019893001 4287650 4290952 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019893001 4287650 4290952 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019893001 4287650 4290952 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019893001 4287650 4290952 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019893001 4287650 4290952 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01019893001 4287650 4290952 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01019893001 4287650 4290952 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01019893001 4287650 4290952 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01019893001 4287650 4290952 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. IEA GO:0048037 cofactor binding GSVIVG01019893001 4287650 4290952 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. IEA GO:0048037 cofactor binding GSVIVG01019893001 4287650 4290952 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. IEA GO:0048037 cofactor binding GSVIVG01019893001 4287650 4290952 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. IEA GO:0048037 cofactor binding GSVIVG01034004001 15972499 15982289 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01034004001 15972499 15982289 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01019774001 3205257 3205706 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01019774001 3205257 3205706 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01019774001 3205257 3205706 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01019774001 3205257 3205706 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01019774001 3205257 3205706 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01019774001 3205257 3205706 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01019774001 3205257 3205706 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01019774001 3205257 3205706 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01019774001 3205257 3205706 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01019774001 3205257 3205706 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01019774001 3205257 3205706 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01019774001 3205257 3205706 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01019774001 3205257 3205706 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01019774001 3205257 3205706 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01019774001 3205257 3205706 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01019774001 3205257 3205706 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01019774001 3205257 3205706 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01019774001 3205257 3205706 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01012413001 591850 595826 GSVIVG01028921001 17512819 17521780 GSVIVG01009072001 4724262 4727279 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01009072001 4724262 4727279 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01035095001 1434327 1452682 GO:0007154 cell communication Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035095001 1434327 1452682 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035095001 1434327 1452682 GO:0007154 cell communication Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035095001 1434327 1452682 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035095001 1434327 1452682 GO:0007154 cell communication Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. IEA Interacting selectively and non-covalently with any inositol-containing glycerophospholipid. Phosphatidylinositol (PtdIns) and its phosphorylated derivatives are collectively referred to as phosphoinositides (PIs). IEA GO:0035091 phosphoinositide binding GSVIVG01035095001 1434327 1452682 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with any inositol-containing glycerophospholipid. Phosphatidylinositol (PtdIns) and its phosphorylated derivatives are collectively referred to as phosphoinositides (PIs). IEA GO:0035091 phosphoinositide binding GSVIVG01018438001 15161779 15166558 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01018438001 15161779 15166558 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01018438001 15161779 15166558 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01018438001 15161779 15166558 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01011041001 2025766 2034257 GSVIVG01021879001 6087924 6092800 GSVIVG01035567001 2365570 2368924 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0005839 proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. IEA GO:0004175 endopeptidase activity GSVIVG01035567001 2365570 2368924 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0005839 proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. IEA Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. IEA GO:0004298 threonine-type endopeptidase activity GSVIVG01017340001 6879058 6883852 GSVIVG01027896001 9144321 9145180 GSVIVG01002468001 34922496 34923639 GSVIVG01001760001 6215853 6219161 GSVIVG01038718001 20638396 20641292 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01038718001 20638396 20641292 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01038718001 20638396 20641292 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01038718001 20638396 20641292 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027545001 15868921 15872017 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01027545001 15868921 15872017 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01027545001 15868921 15872017 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01027545001 15868921 15872017 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01027545001 15868921 15872017 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01027545001 15868921 15872017 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01015716001 16267841 16268915 GSVIVG01026237001 14610619 14612634 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01026237001 14610619 14612634 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01026237001 14610619 14612634 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01026237001 14610619 14612634 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01021225001 2725731 2732279 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01014696001 8728277 8730857 GSVIVG01000866001 3196349 3201758 GSVIVG01016672001 272020 274836 GSVIVG01000812001 443609 459784 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000812001 443609 459784 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000812001 443609 459784 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000812001 443609 459784 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01000812001 443609 459784 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01000812001 443609 459784 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01000812001 443609 459784 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01000812001 443609 459784 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01000812001 443609 459784 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01005786001 21976630 21980400 GSVIVG01038181001 24126799 24139086 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01038181001 24126799 24139086 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01021648001 8695760 8717864 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01021648001 8695760 8717864 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01021648001 8695760 8717864 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01021648001 8695760 8717864 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01021648001 8695760 8717864 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01021648001 8695760 8717864 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01021648001 8695760 8717864 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01021648001 8695760 8717864 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01021648001 8695760 8717864 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021648001 8695760 8717864 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009332001 7499914 7512039 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GSVIVG01017900001 4488819 4490843 GSVIVG01017685001 2644682 2648982 GSVIVG01035559001 2303750 2304814 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01009240001 6547019 6549993 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01009240001 6547019 6549993 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA A ligand-dependent receptor found in the nucleus of the cell. IEA GO:0004879 ligand-dependent nuclear receptor activity GSVIVG01009240001 6547019 6549993 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01009240001 6547019 6549993 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01016807001 1560195 1567115 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01016807001 1560195 1567115 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01016807001 1560195 1567115 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01016807001 1560195 1567115 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01004643001 39326295 39328591 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01004643001 39326295 39328591 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01019662001 2305371 2307052 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01018223001 12989262 13025566 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018223001 12989262 13025566 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01022477001 3508875 3511996 GSVIVG01028465001 7996513 8009262 GO:0006014 D-ribose metabolic process The chemical reactions and pathways involving D-ribose (ribo-pentose). As beta-D-ribofuranose, D-ribose forms the glycose moiety of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12. IEA Catalysis of the reaction: ATP + D-ribose = ADP + D-ribose 5-phosphate. IEA GO:0004747 ribokinase activity GSVIVG01027105001 17879750 17881920 GSVIVG01006719001 1228931 1235857 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01011046001 1983342 1994011 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01011046001 1983342 1994011 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01011046001 1983342 1994011 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01011046001 1983342 1994011 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009320001 7338029 7417123 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009320001 7338029 7417123 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009320001 7338029 7417123 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009320001 7338029 7417123 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009320001 7338029 7417123 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009320001 7338029 7417123 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009320001 7338029 7417123 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009320001 7338029 7417123 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009320001 7338029 7417123 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01009320001 7338029 7417123 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01009320001 7338029 7417123 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01009320001 7338029 7417123 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01009320001 7338029 7417123 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01009320001 7338029 7417123 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01009320001 7338029 7417123 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01009320001 7338029 7417123 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01009320001 7338029 7417123 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009320001 7338029 7417123 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009320001 7338029 7417123 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009320001 7338029 7417123 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009320001 7338029 7417123 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009320001 7338029 7417123 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009320001 7338029 7417123 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009320001 7338029 7417123 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009320001 7338029 7417123 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01009320001 7338029 7417123 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01009320001 7338029 7417123 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01009320001 7338029 7417123 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01009320001 7338029 7417123 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01009320001 7338029 7417123 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01009320001 7338029 7417123 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01009320001 7338029 7417123 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01009320001 7338029 7417123 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01009320001 7338029 7417123 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01009320001 7338029 7417123 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01009320001 7338029 7417123 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01009320001 7338029 7417123 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01009320001 7338029 7417123 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01009320001 7338029 7417123 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01009320001 7338029 7417123 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01025813001 11586337 11592172 GSVIVG01012191001 679483 685333 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012191001 679483 685333 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012191001 679483 685333 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01012191001 679483 685333 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01012191001 679483 685333 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of terminal, non-reducing beta-D-glucose residues with release of beta-D-glucose. IEA GO:0008422 beta-glucosidase activity GSVIVG01012191001 679483 685333 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of terminal, non-reducing beta-D-glucose residues with release of beta-D-glucose. IEA GO:0008422 beta-glucosidase activity GSVIVG01012191001 679483 685333 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01012191001 679483 685333 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01012191001 679483 685333 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01012191001 679483 685333 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01012191001 679483 685333 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01012191001 679483 685333 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01031660001 19742597 19743497 GSVIVG01006259001 24139568 24140810 GSVIVG01035297001 170111 174712 GO:0022904 respiratory electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01035297001 170111 174712 GO:0022904 respiratory electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01012458001 1165688 1166867 GSVIVG01029769001 14435653 14437557 GSVIVG01011109001 1499725 1504750 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01017470001 8868969 8873698 GSVIVG01010464001 20813288 20814946 GSVIVG01010333001 19574855 19576375 GSVIVG01009433001 8301280 8324703 GSVIVG01008535001 1030106 1032033 GO:0006887 exocytosis A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell. This is the process whereby most molecules are secreted from eukaryotic cells. IEA GO:0000145 exocyst A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals. IEA GSVIVG01003863001 12996877 12997304 GSVIVG01031365001 19550559 19636937 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01031365001 19550559 19636937 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01031365001 19550559 19636937 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01031365001 19550559 19636937 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01031365001 19550559 19636937 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01031365001 19550559 19636937 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01031365001 19550559 19636937 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and primer. IEA GO:0003887 DNA-directed DNA polymerase activity GSVIVG01031365001 19550559 19636937 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and primer. IEA GO:0003887 DNA-directed DNA polymerase activity GSVIVG01031365001 19550559 19636937 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01031365001 19550559 19636937 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008411001 2349564 2352147 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01008411001 2349564 2352147 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01008411001 2349564 2352147 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01008411001 2349564 2352147 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01008411001 2349564 2352147 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01008411001 2349564 2352147 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01008411001 2349564 2352147 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01008411001 2349564 2352147 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01023483001 11117582 11119477 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028697001 19705689 19707428 GSVIVG01006283001 24528762 24528959 GSVIVG01016822001 1670135 1692366 GO:0016459 myosin complex A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. IEA Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate. IEA GO:0003774 motor activity GSVIVG01016822001 1670135 1692366 GO:0016459 myosin complex A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021139001 1759347 1762768 GSVIVG01003464001 10518057 10520944 GSVIVG01001596001 18227134 18232345 GSVIVG01019456001 805239 806989 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01019456001 805239 806989 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01036396001 4590052 4608842 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01011481001 29966052 29967923 GSVIVG01029032001 10944035 10946420 GO:0009228 thiamin biosynthetic process The chemical reactions and pathways resulting in the formation of thiamin (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver. IEA Catalysis of the reaction: ATP + 4-methyl-5-(2-hydroxyethyl)-thiazole = ADP + 4-methyl-5-(2-phosphoethyl)-thiazole. IEA GO:0004417 hydroxyethylthiazole kinase activity GSVIVG01027160001 17348763 17355815 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01027160001 17348763 17355815 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01009962001 12859117 12862545 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01001709001 12541258 12542643 GO:0006278 RNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01001709001 12541258 12542643 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01001709001 12541258 12542643 GO:0006278 RNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01001709001 12541258 12542643 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01001709001 12541258 12542643 GO:0006278 RNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01001709001 12541258 12542643 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01001709001 12541258 12542643 GO:0006278 RNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. IEA Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time. IEA GO:0003964 RNA-directed DNA polymerase activity GSVIVG01001709001 12541258 12542643 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time. IEA GO:0003964 RNA-directed DNA polymerase activity GSVIVG01001709001 12541258 12542643 GO:0006278 RNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01001709001 12541258 12542643 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01028197001 4544906 4546027 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01028197001 4544906 4546027 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01028197001 4544906 4546027 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01028197001 4544906 4546027 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01028197001 4544906 4546027 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01028197001 4544906 4546027 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01028197001 4544906 4546027 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01028197001 4544906 4546027 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01028197001 4544906 4546027 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01028197001 4544906 4546027 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01016065001 18265903 18267105 GSVIVG01034622001 14122289 14122459 GSVIVG01013507001 1995033 1998710 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01013507001 1995033 1998710 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01013507001 1995033 1998710 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013507001 1995033 1998710 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013507001 1995033 1998710 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013507001 1995033 1998710 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013507001 1995033 1998710 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01013507001 1995033 1998710 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01001528001 1034585 1040126 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01003960001 14062656 14086212 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01027318001 16652440 16684430 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009735001 10857773 10863529 Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01004811001 92751 99853 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01004811001 92751 99853 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01004811001 92751 99853 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01004811001 92751 99853 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01004811001 92751 99853 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01004811001 92751 99853 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01004811001 92751 99853 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01004811001 92751 99853 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01011451001 29765355 29767914 GSVIVG01032444001 27461360 27478109 GO:0000226 microtubule cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. IEA GO:0000922 spindle pole Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules. IEA GSVIVG01032444001 27461360 27478109 GO:0000226 microtubule cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. IEA GO:0005815 microtubule organizing center A cytoplasmic structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides. IEA GSVIVG01016142001 19665642 19666009 GSVIVG01024257001 272615 273266 GSVIVG01035586001 2530927 2532401 GO:0006526 arginine biosynthetic process The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate. IEA GO:0003991 acetylglutamate kinase activity GSVIVG01035586001 2530927 2532401 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate. IEA GO:0003991 acetylglutamate kinase activity GSVIVG01030179001 10799442 10803380 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01030179001 10799442 10803380 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01030179001 10799442 10803380 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01030179001 10799442 10803380 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030179001 10799442 10803380 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007589001 11592928 11594130 GSVIVG01033319001 21533306 21555911 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028757001 19135127 19149867 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01028757001 19135127 19149867 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01028757001 19135127 19149867 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01028757001 19135127 19149867 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01029554001 21647466 21652635 GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA GSVIVG01025359001 1549134 1552675 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01022929001 17885189 17886396 GSVIVG01033597001 19441465 19444795 GSVIVG01030235001 10144461 10145851 GSVIVG01021269001 3230618 3233670 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01021269001 3230618 3233670 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01026985001 18819105 18821478 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01035590001 2562865 2571626 GSVIVG01038108001 23528812 23532402 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01038108001 23528812 23532402 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01038108001 23528812 23532402 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01007040001 29838725 29841471 GSVIVG01013682001 2543256 2556036 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013682001 2543256 2556036 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013682001 2543256 2556036 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013682001 2543256 2556036 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013682001 2543256 2556036 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01013682001 2543256 2556036 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01013682001 2543256 2556036 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01013682001 2543256 2556036 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01013682001 2543256 2556036 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription. IEA GO:0008134 transcription factor binding GSVIVG01013682001 2543256 2556036 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription. IEA GO:0008134 transcription factor binding GSVIVG01013682001 2543256 2556036 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription. IEA GO:0008134 transcription factor binding GSVIVG01013682001 2543256 2556036 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription. IEA GO:0008134 transcription factor binding GSVIVG01019884001 4225246 4227170 GSVIVG01036339001 3959835 3960533 Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01036339001 3959835 3960533 Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01010053001 13865194 13867490 GSVIVG01012170001 797708 800133 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01012170001 797708 800133 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01012170001 797708 800133 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01012170001 797708 800133 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01012170001 797708 800133 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01012170001 797708 800133 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01012170001 797708 800133 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01012170001 797708 800133 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01012170001 797708 800133 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01010322001 19486355 19493500 GSVIVG01032307001 14842401 14847554 GSVIVG01012514001 391135 407738 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01014462001 4092388 4097206 GSVIVG01027069001 18191021 18193489 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01027069001 18191021 18193489 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01030190001 10702225 10703466 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with a lipid. IEA GO:0008289 lipid binding GSVIVG01030190001 10702225 10703466 GO:0006869 lipid transport The directed movement of lipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Interacting selectively and non-covalently with a lipid. IEA GO:0008289 lipid binding GSVIVG01020876001 718172 719578 GSVIVG01007937001 7343336 7345183 GSVIVG01037822001 7469818 7484328 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01037822001 7469818 7484328 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01037822001 7469818 7484328 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01033406001 20932022 20936461 GO:0000103 sulfate assimilation The pathways by which inorganic sulfate is processed and incorporated into sulfated compounds. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033406001 20932022 20936461 GO:0000103 sulfate assimilation The pathways by which inorganic sulfate is processed and incorporated into sulfated compounds. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01033406001 20932022 20936461 GO:0000103 sulfate assimilation The pathways by which inorganic sulfate is processed and incorporated into sulfated compounds. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01028037001 3345378 3348216 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021117001 1606572 1609477 GSVIVG01028046001 3430668 3431083 GSVIVG01025675001 13025473 13029237 GSVIVG01008387001 2576750 2586959 GO:0007031 peroxisome organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules. IEA GO:0005779 integral to peroxisomal membrane Penetrating at least one phospholipid bilayer of a peroxisomal membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA GSVIVG01025383001 1206614 1210854 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01025383001 1206614 1210854 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01012089001 1551756 1553292 GSVIVG01015194001 1702553 1704880 GO:0009690 cytokinin metabolic process The chemical reactions and pathways involving cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015194001 1702553 1704880 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015194001 1702553 1704880 GO:0009690 cytokinin metabolic process The chemical reactions and pathways involving cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01015194001 1702553 1704880 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01015194001 1702553 1704880 GO:0009690 cytokinin metabolic process The chemical reactions and pathways involving cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators. IEA Catalysis of the reaction: N6-dimethylallyladenine + acceptor + H2O = adenine + 3-methylbut-2-enal + reduced electron acceptor. IEA GO:0019139 cytokinin dehydrogenase activity GSVIVG01015194001 1702553 1704880 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: N6-dimethylallyladenine + acceptor + H2O = adenine + 3-methylbut-2-enal + reduced electron acceptor. IEA GO:0019139 cytokinin dehydrogenase activity GSVIVG01015194001 1702553 1704880 GO:0009690 cytokinin metabolic process The chemical reactions and pathways involving cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01015194001 1702553 1704880 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01000364001 39761 40234 GSVIVG01028798001 18691678 18698719 GSVIVG01004944001 21739813 21740747 GSVIVG01025669001 13066733 13069777 GSVIVG01020895001 17630461 17640343 GSVIVG01020310001 21573407 21590123 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with transfer RNA. IEA GO:0000049 tRNA binding GSVIVG01020310001 21573407 21590123 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe). IEA GO:0004826 phenylalanine-tRNA ligase activity GSVIVG01020310001 21573407 21590123 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012205001 573526 579404 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032976001 24755005 24755286 GSVIVG01001048001 7034349 7037471 GSVIVG01031933001 5536347 5538415 GSVIVG01027852001 8648517 8650936 GSVIVG01009361001 7749437 7763469 GSVIVG01008722001 1451426 1451971 GSVIVG01020187001 9302374 9306029 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01028598001 10431218 10433982 GO:0009690 cytokinin metabolic process The chemical reactions and pathways involving cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028598001 10431218 10433982 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028598001 10431218 10433982 GO:0009690 cytokinin metabolic process The chemical reactions and pathways involving cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators. IEA Catalysis of the reaction: N6-dimethylallyladenine + acceptor + H2O = adenine + 3-methylbut-2-enal + reduced electron acceptor. IEA GO:0019139 cytokinin dehydrogenase activity GSVIVG01028598001 10431218 10433982 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: N6-dimethylallyladenine + acceptor + H2O = adenine + 3-methylbut-2-enal + reduced electron acceptor. IEA GO:0019139 cytokinin dehydrogenase activity GSVIVG01028598001 10431218 10433982 GO:0009690 cytokinin metabolic process The chemical reactions and pathways involving cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01028598001 10431218 10433982 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01028548001 9546235 9551518 GSVIVG01000927001 21992965 21995256 GSVIVG01035856001 4918740 4922961 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GSVIVG01023424001 12265505 12266250 GSVIVG01028917001 17577187 17578280 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01028917001 17577187 17578280 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01021852001 6493862 6504104 GSVIVG01029087001 12262126 12304003 GO:0006269 DNA replication, synthesis of RNA primer The synthesis of a short RNA polymer, usually 4-15 nucleotides long, using one strand of unwound DNA as a template; the RNA then serves as a primer from which DNA polymerases extend synthesis. IEA Catalysis of the synthesis of a short RNA primer on a DNA template, providing a free 3'-OH that can be extended by DNA-directed DNA polymerases. Catalyzed by a DNA-directed RNA polymerase that forms a complex with alpha DNA polymerase. IEA GO:0003896 DNA primase activity GSVIVG01017029001 3584004 3601608 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01017029001 3584004 3601608 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01017029001 3584004 3601608 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01017029001 3584004 3601608 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01017029001 3584004 3601608 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017029001 3584004 3601608 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01017029001 3584004 3601608 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01005736001 13957479 13966580 GSVIVG01017493001 9422914 9424150 GSVIVG01016164001 7257995 7258591 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01016164001 7257995 7258591 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01015910001 19194574 19201576 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01015910001 19194574 19201576 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01015910001 19194574 19201576 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034587001 14838753 14838930 GSVIVG01014454001 3913823 3915339 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01013288001 5625023 5625771 GSVIVG01031936001 5554223 5560456 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01004669001 39481285 39482131 GSVIVG01033637001 19067027 19074162 GSVIVG01003599001 11133929 11149989 GSVIVG01015407001 3341777 3358131 GO:0006298 mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01015407001 3341777 3358131 GO:0006298 mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015407001 3341777 3358131 GO:0006298 mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01015407001 3341777 3358131 GO:0006298 mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. IEA Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches. IEA GO:0030983 mismatched DNA binding GSVIVG01016739001 829349 832094 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01016739001 829349 832094 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01016739001 829349 832094 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01016739001 829349 832094 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01038392001 11654056 11654657 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01027436001 16734671 16736088 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01027436001 16734671 16736088 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01027436001 16734671 16736088 GO:0006414 translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01027436001 16734671 16736088 GO:0006414 translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01005957001 22896802 22897391 GSVIVG01025459001 690250 690456 GSVIVG01036183001 19723340 19724452 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01036285001 3384788 3387393 GSVIVG01020825001 1500712 1504870 GSVIVG01020814001 1646903 1650547 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01009354001 7636179 7650724 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01030028001 8999044 8999919 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01030028001 8999044 8999919 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01030028001 8999044 8999919 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01030028001 8999044 8999919 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01030028001 8999044 8999919 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030028001 8999044 8999919 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035993001 6915645 6921266 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01023736001 10262767 10263784 GSVIVG01033897001 16919460 16922307 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01033897001 16919460 16922307 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01033897001 16919460 16922307 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01008044001 6357705 6361223 GSVIVG01006954001 29340557 29361260 GSVIVG01015346001 2850752 2852779 GSVIVG01013529001 2394871 2396387 GSVIVG01030770001 15688056 15693171 GSVIVG01032430001 27319398 27322069 GSVIVG01033547001 19847325 19849931 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01011348001 28868694 28870986 Catalysis of the eliminative cleavage of pectate to give oligosaccharides with 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their non-reducing ends. IEA GO:0030570 pectate lyase activity GSVIVG01029954001 2127042 2134172 GSVIVG01029774001 14484465 14485953 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01029774001 14484465 14485953 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01029774001 14484465 14485953 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01029774001 14484465 14485953 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01026890001 19614054 19620297 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01026890001 19614054 19620297 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01026890001 19614054 19620297 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01026890001 19614054 19620297 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01011204001 9424055 9429567 GSVIVG01004671001 39492482 39493957 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01016054001 18080689 18083858 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01016054001 18080689 18083858 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01016054001 18080689 18083858 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01016054001 18080689 18083858 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016054001 18080689 18083858 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017219001 5571246 5583930 GSVIVG01036758001 22924599 22935504 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01036758001 22924599 22935504 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01036758001 22924599 22935504 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01036758001 22924599 22935504 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014910001 11673061 11675599 GSVIVG01037691001 6924771 6926335 GSVIVG01024736001 7348510 7352026 GSVIVG01029142001 19253944 19265299 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01029142001 19253944 19265299 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01029142001 19253944 19265299 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01029142001 19253944 19265299 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01021403001 4942315 4948429 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01036895001 18028405 18030254 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01012827001 5803553 5809681 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01012827001 5803553 5809681 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01012827001 5803553 5809681 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01012827001 5803553 5809681 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01012827001 5803553 5809681 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016295001 5428672 5430473 GO:0009765 photosynthesis, light harvesting Absorption and transfer of the energy absorbed from light photons between photosystem reaction centers. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA GSVIVG01016295001 5428672 5430473 GO:0009765 photosynthesis, light harvesting Absorption and transfer of the energy absorbed from light photons between photosystem reaction centers. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01030883001 18316603 18317706 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01016657001 172954 178026 GSVIVG01023579001 9382342 9383520 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023579001 9382342 9383520 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023579001 9382342 9383520 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023579001 9382342 9383520 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023579001 9382342 9383520 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01023579001 9382342 9383520 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01023579001 9382342 9383520 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01023579001 9382342 9383520 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01015158001 1431038 1446814 GSVIVG01033464001 20455686 20461582 GO:0006306 DNA methylation The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01033464001 20455686 20461582 GO:0006306 DNA methylation The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01033464001 20455686 20461582 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01033464001 20455686 20461582 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01033464001 20455686 20461582 GO:0006306 DNA methylation The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Interacting selectively and non-covalently with chromatin, the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase. IEA GO:0003682 chromatin binding GSVIVG01033464001 20455686 20461582 GO:0006306 DNA methylation The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with chromatin, the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase. IEA GO:0003682 chromatin binding GSVIVG01033464001 20455686 20461582 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Interacting selectively and non-covalently with chromatin, the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase. IEA GO:0003682 chromatin binding GSVIVG01033464001 20455686 20461582 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with chromatin, the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase. IEA GO:0003682 chromatin binding GSVIVG01019730001 2793848 2803836 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008237 metallopeptidase activity GSVIVG01019730001 2793848 2803836 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01027734001 7321488 7322977 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01012832001 5915836 5917238 GSVIVG01008886001 3149243 3169300 GSVIVG01036104001 20654460 20657763 GSVIVG01030024001 8984633 8985521 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01029001001 10470707 10502773 GSVIVG01008148001 5354564 5357443 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008148001 5354564 5357443 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01025573001 13965068 13974515 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025573001 13965068 13974515 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01024762001 7155732 7163416 GSVIVG01015518001 4399819 4403127 Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01008883001 3102029 3103369 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01017497001 9470369 9483337 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01017497001 9470369 9483337 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). IEA GO:0016769 transferase activity, transferring nitrogenous groups GSVIVG01017497001 9470369 9483337 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01013750001 7943322 7945676 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage. IEA GO:0016209 antioxidant activity GSVIVG01013750001 7943322 7945676 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022939001 17798388 17801834 GSVIVG01030987001 20346725 20347075 GSVIVG01001148001 1297167 1305419 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA GSVIVG01001148001 1297167 1305419 GO:0006415 translational termination The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code). IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA GSVIVG01026641001 20804641 20807243 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01026641001 20804641 20807243 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026641001 20804641 20807243 Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01026641001 20804641 20807243 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01013497001 1922439 1924034 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01013497001 1922439 1924034 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01035184001 10045692 10052718 GSVIVG01026515001 22391451 22398790 GSVIVG01010382001 20019343 20022287 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01008413001 2321687 2342403 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01008413001 2321687 2342403 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01008413001 2321687 2342403 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01008413001 2321687 2342403 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021567001 7155621 7156660 GSVIVG01018924001 18606817 18616260 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01018924001 18606817 18616260 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01018924001 18606817 18616260 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01008500001 1309752 1312896 GSVIVG01025275001 2529440 2545810 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025275001 2529440 2545810 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01038145001 23866670 23876835 GSVIVG01032761001 959131 959652 GSVIVG01011095001 1634510 1639027 GSVIVG01001123001 22815076 22819209 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01001123001 22815076 22819209 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01001123001 22815076 22819209 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01001123001 22815076 22819209 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01001123001 22815076 22819209 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01001123001 22815076 22819209 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01001123001 22815076 22819209 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01001123001 22815076 22819209 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01001123001 22815076 22819209 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01001123001 22815076 22819209 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01001123001 22815076 22819209 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01001123001 22815076 22819209 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01001123001 22815076 22819209 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01001123001 22815076 22819209 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01001123001 22815076 22819209 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01001123001 22815076 22819209 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01001123001 22815076 22819209 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01001123001 22815076 22819209 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01001123001 22815076 22819209 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01001123001 22815076 22819209 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01001123001 22815076 22819209 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001123001 22815076 22819209 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001123001 22815076 22819209 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001123001 22815076 22819209 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001123001 22815076 22819209 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01001123001 22815076 22819209 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01001123001 22815076 22819209 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01001123001 22815076 22819209 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01001123001 22815076 22819209 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces an oxygen molecule. IEA GO:0050664 oxidoreductase activity, acting on NADH or NADPH, with oxygen as acceptor GSVIVG01001123001 22815076 22819209 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces an oxygen molecule. IEA GO:0050664 oxidoreductase activity, acting on NADH or NADPH, with oxygen as acceptor GSVIVG01001123001 22815076 22819209 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces an oxygen molecule. IEA GO:0050664 oxidoreductase activity, acting on NADH or NADPH, with oxygen as acceptor GSVIVG01001123001 22815076 22819209 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces an oxygen molecule. IEA GO:0050664 oxidoreductase activity, acting on NADH or NADPH, with oxygen as acceptor GSVIVG01018288001 11737840 11853020 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01018288001 11737840 11853020 GO:0006426 glycyl-tRNA aminoacylation The process of coupling glycine to glycyl-tRNA, catalyzed by glycyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01018288001 11737840 11853020 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly). IEA GO:0004820 glycine-tRNA ligase activity GSVIVG01018288001 11737840 11853020 GO:0006426 glycyl-tRNA aminoacylation The process of coupling glycine to glycyl-tRNA, catalyzed by glycyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly). IEA GO:0004820 glycine-tRNA ligase activity GSVIVG01018288001 11737840 11853020 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018288001 11737840 11853020 GO:0006426 glycyl-tRNA aminoacylation The process of coupling glycine to glycyl-tRNA, catalyzed by glycyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009030001 4407299 4416705 GSVIVG01007009001 29716357 29725155 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007009001 29716357 29725155 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007009001 29716357 29725155 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007009001 29716357 29725155 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007009001 29716357 29725155 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007009001 29716357 29725155 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01007009001 29716357 29725155 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01007009001 29716357 29725155 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01007009001 29716357 29725155 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01007009001 29716357 29725155 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01007009001 29716357 29725155 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01007009001 29716357 29725155 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01007009001 29716357 29725155 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01007009001 29716357 29725155 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01007009001 29716357 29725155 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01007009001 29716357 29725155 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007009001 29716357 29725155 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007009001 29716357 29725155 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007009001 29716357 29725155 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007009001 29716357 29725155 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007009001 29716357 29725155 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of calcium (Ca) ions from one side of a membrane to the other. IEA GO:0015085 calcium ion transmembrane transporter activity GSVIVG01007009001 29716357 29725155 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of calcium (Ca) ions from one side of a membrane to the other. IEA GO:0015085 calcium ion transmembrane transporter activity GSVIVG01007009001 29716357 29725155 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of calcium (Ca) ions from one side of a membrane to the other. IEA GO:0015085 calcium ion transmembrane transporter activity GSVIVG01007009001 29716357 29725155 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of calcium (Ca) ions from one side of a membrane to the other. IEA GO:0015085 calcium ion transmembrane transporter activity GSVIVG01007009001 29716357 29725155 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of calcium (Ca) ions from one side of a membrane to the other. IEA GO:0015085 calcium ion transmembrane transporter activity GSVIVG01007009001 29716357 29725155 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01007009001 29716357 29725155 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01007009001 29716357 29725155 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01007009001 29716357 29725155 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01007009001 29716357 29725155 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01007009001 29716357 29725155 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01007009001 29716357 29725155 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01007009001 29716357 29725155 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01007009001 29716357 29725155 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01007009001 29716357 29725155 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01019022001 17638953 17641872 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01000250001 20539010 20539762 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01000250001 20539010 20539762 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01000250001 20539010 20539762 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01000250001 20539010 20539762 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01000250001 20539010 20539762 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01000250001 20539010 20539762 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01009601001 9787515 9794746 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01009601001 9787515 9794746 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01009601001 9787515 9794746 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01009601001 9787515 9794746 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01017166001 4889366 4891937 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017166001 4889366 4891937 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017166001 4889366 4891937 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017166001 4889366 4891937 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022914001 18112713 18114646 Functions in the storage of nutritious substrates. IEA GO:0045735 nutrient reservoir activity GSVIVG01026855001 19922605 19923134 GSVIVG01007370001 31549742 31552043 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01007370001 31549742 31552043 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01007370001 31549742 31552043 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01007370001 31549742 31552043 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034858001 22922148 22923585 GSVIVG01010565001 16551343 16557512 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010565001 16551343 16557512 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010565001 16551343 16557512 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010565001 16551343 16557512 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01010565001 16551343 16557512 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01010565001 16551343 16557512 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01010565001 16551343 16557512 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01010565001 16551343 16557512 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01010565001 16551343 16557512 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01014841001 10455400 10463846 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01009767001 11137543 11137828 GSVIVG01002544001 35275843 35289143 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01035537001 2122617 2125697 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01025737001 12410697 12415338 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c The transfer of electrons from ubiquinol to cytochrome c that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex III. IEA GO:0005740 mitochondrial envelope The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+. IEA GO:0008121 ubiquinol-cytochrome-c reductase activity GSVIVG01014752001 9229430 9239572 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01014752001 9229430 9239572 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009265001 6810138 6817991 GO:0032957 inositol trisphosphate metabolic process The chemical reactions and pathways involving myo-inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with three phosphate groups attached. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01009265001 6810138 6817991 GO:0032957 inositol trisphosphate metabolic process The chemical reactions and pathways involving myo-inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with three phosphate groups attached. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009265001 6810138 6817991 GO:0032957 inositol trisphosphate metabolic process The chemical reactions and pathways involving myo-inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with three phosphate groups attached. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009265001 6810138 6817991 GO:0032957 inositol trisphosphate metabolic process The chemical reactions and pathways involving myo-inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with three phosphate groups attached. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reactions: ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate and ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate. IEA GO:0035300 inositol-1,3,4-trisphosphate 5/6-kinase activity GSVIVG01009265001 6810138 6817991 GO:0032957 inositol trisphosphate metabolic process The chemical reactions and pathways involving myo-inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with three phosphate groups attached. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: 1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP. IEA GO:0047325 inositol tetrakisphosphate 1-kinase activity GSVIVG01014869001 10934467 10947175 GSVIVG01010788001 22582037 22588193 GSVIVG01035424001 1197261 1200854 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01035424001 1197261 1200854 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01035424001 1197261 1200854 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid. IEA GO:0008825 cyclopropane-fatty-acyl-phospholipid synthase activity GSVIVG01035424001 1197261 1200854 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid. IEA GO:0008825 cyclopropane-fatty-acyl-phospholipid synthase activity GSVIVG01009587001 9679965 9680799 GO:0009512 cytochrome b6f complex Complex that transfers electrons from reduced plastoquinone to oxidized plastocyanin and translocates protons from the stroma to the lumen. The complex contains a core structure of three catalytic subunits: cytochrome b, the Rieske iron sulfur protein (ISP), and cytochrome f, which are arranged in an integral membrane-bound dimeric complex; additional subunits are present, and vary among different species. IEA GSVIVG01008152001 5278333 5292370 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with double-stranded RNA. IEA GO:0003725 double-stranded RNA binding GSVIVG01018276001 12144527 12149725 GSVIVG01029262001 17872993 17884947 GSVIVG01035979001 6751663 6752535 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01027528001 15970534 15970959 GSVIVG01000969001 22356346 22356408 GSVIVG01024219001 126116 137455 GSVIVG01014211001 1494737 1500193 GO:0019277 UDP-N-acetylgalactosamine biosynthetic process The chemical reactions and pathways resulting in the formation of UDP-N-acetylgalactosamine, a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01014211001 1494737 1500193 GO:0019277 UDP-N-acetylgalactosamine biosynthetic process The chemical reactions and pathways resulting in the formation of UDP-N-acetylgalactosamine, a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01014211001 1494737 1500193 GO:0019277 UDP-N-acetylgalactosamine biosynthetic process The chemical reactions and pathways resulting in the formation of UDP-N-acetylgalactosamine, a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate. IEA Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor). IEA GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups GSVIVG01025376001 1249125 1254078 GO:0009396 folic acid and derivative biosynthetic process The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. IEA Catalysis of the reaction: ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. IEA GO:0004329 formate-tetrahydrofolate ligase activity GSVIVG01025376001 1249125 1254078 GO:0009396 folic acid and derivative biosynthetic process The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019690001 2485420 2489802 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01019690001 2485420 2489802 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01009716001 10722458 10723347 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01004779001 16042246 16054399 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01004779001 16042246 16054399 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01004779001 16042246 16054399 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01004779001 16042246 16054399 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Catalysis of the reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]. IEA GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity GSVIVG01004779001 16042246 16054399 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]. IEA GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity GSVIVG01004779001 16042246 16054399 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]. IEA GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity GSVIVG01004779001 16042246 16054399 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01004779001 16042246 16054399 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01004779001 16042246 16054399 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01013786001 7624424 7625611 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013786001 7624424 7625611 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01030549001 6643787 6645077 Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. IEA GO:0008171 O-methyltransferase activity GSVIVG01005854001 22268963 22270205 GSVIVG01013826001 4909330 4914694 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01022661001 14280776 14281843 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01026255001 14994624 15002909 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01026255001 14994624 15002909 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01008096001 5814755 5818561 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01001737001 649165 659470 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001737001 649165 659470 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01001737001 649165 659470 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01015002001 343107 347955 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01015002001 343107 347955 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01015002001 343107 347955 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01015002001 343107 347955 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01015002001 343107 347955 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01015002001 343107 347955 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01015002001 343107 347955 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA Interacting selectively and non-covalently with damaged DNA. IEA GO:0003684 damaged DNA binding GSVIVG01015002001 343107 347955 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Interacting selectively and non-covalently with damaged DNA. IEA GO:0003684 damaged DNA binding GSVIVG01015002001 343107 347955 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with damaged DNA. IEA GO:0003684 damaged DNA binding GSVIVG01015002001 343107 347955 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01015002001 343107 347955 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01015002001 343107 347955 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01015002001 343107 347955 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01015002001 343107 347955 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01015002001 343107 347955 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01015002001 343107 347955 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015002001 343107 347955 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015002001 343107 347955 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015002001 343107 347955 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate in the presence of single- or double-stranded DNA; drives another reaction. IEA GO:0008094 DNA-dependent ATPase activity GSVIVG01015002001 343107 347955 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate in the presence of single- or double-stranded DNA; drives another reaction. IEA GO:0008094 DNA-dependent ATPase activity GSVIVG01015002001 343107 347955 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate in the presence of single- or double-stranded DNA; drives another reaction. IEA GO:0008094 DNA-dependent ATPase activity GSVIVG01015002001 343107 347955 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01015002001 343107 347955 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01015002001 343107 347955 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01025421001 935380 940685 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01038417001 11997227 11998743 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01008665001 34822 36451 GSVIVG01032258001 14151765 14155401 GSVIVG01011996001 2344272 2344630 GSVIVG01022915001 18103606 18112709 GSVIVG01028305001 5933704 5940245 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008521001 1137078 1137550 GSVIVG01002051001 32468368 32478679 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01002051001 32468368 32478679 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01002051001 32468368 32478679 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). IEA GO:0003755 peptidyl-prolyl cis-trans isomerase activity GSVIVG01002051001 32468368 32478679 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). IEA GO:0003755 peptidyl-prolyl cis-trans isomerase activity GSVIVG01002051001 32468368 32478679 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids. IEA GO:0004518 nuclease activity GSVIVG01002051001 32468368 32478679 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids. IEA GO:0004518 nuclease activity GSVIVG01002051001 32468368 32478679 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01002051001 32468368 32478679 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000223001 16233326 16236429 Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers. IEA GO:0008017 microtubule binding GSVIVG01001666001 14075968 14077515 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01001666001 14075968 14077515 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01001666001 14075968 14077515 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01001666001 14075968 14077515 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031249001 818673 825010 GSVIVG01025268001 2581377 2586304 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01025268001 2581377 2586304 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01008145001 5393704 5394224 GSVIVG01015864001 18586109 18586671 GSVIVG01013686001 2618009 2632515 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01013686001 2618009 2632515 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01013686001 2618009 2632515 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01013686001 2618009 2632515 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01013686001 2618009 2632515 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01013686001 2618009 2632515 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013686001 2618009 2632515 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013686001 2618009 2632515 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013686001 2618009 2632515 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013686001 2618009 2632515 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013686001 2618009 2632515 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01013686001 2618009 2632515 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01013686001 2618009 2632515 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01013686001 2618009 2632515 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01013686001 2618009 2632515 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01017728001 2970890 2971437 GSVIVG01008917001 3380427 3383311 GSVIVG01006486001 26443352 26447930 GSVIVG01002525001 35193406 35196337 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01002525001 35193406 35196337 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01002525001 35193406 35196337 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01002525001 35193406 35196337 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028361001 6587990 6611981 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01028361001 6587990 6611981 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01028361001 6587990 6611981 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01028361001 6587990 6611981 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008514001 1231702 1237709 GSVIVG01026120001 24337377 24344120 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01009700001 10590637 10594953 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009700001 10590637 10594953 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01009700001 10590637 10594953 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01019040001 17477774 17479756 GSVIVG01035338001 601645 609800 GSVIVG01025434001 819203 822704 GSVIVG01003792001 12770264 12772223 GSVIVG01001201001 849143 850521 GSVIVG01029172001 18949294 18956457 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01008366001 2821133 2821522 GSVIVG01025730001 12528862 12533070 GSVIVG01023370001 19220033 19221940 GO:0006306 DNA methylation The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01028876001 17903071 17905473 GSVIVG01009738001 10882084 10891128 Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01019085001 16845198 16845383 GSVIVG01023136001 22189732 22221729 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023136001 22189732 22221729 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01015823001 17907034 17917706 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01015823001 17907034 17917706 Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium. IEA GO:0005544 calcium-dependent phospholipid binding GSVIVG01021627001 8385360 8386206 GSVIVG01024053001 1480621 1483272 GSVIVG01022426001 20057774 20077418 GO:0006779 porphyrin biosynthetic process The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group. IEA Catalysis of the reaction: protoporphyrin + Fe2+ = protoheme + 2 H+. IEA GO:0004325 ferrochelatase activity GSVIVG01022426001 20057774 20077418 GO:0006783 heme biosynthetic process The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors. IEA Catalysis of the reaction: protoporphyrin + Fe2+ = protoheme + 2 H+. IEA GO:0004325 ferrochelatase activity GSVIVG01022426001 20057774 20077418 GO:0006779 porphyrin biosynthetic process The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01022426001 20057774 20077418 GO:0006783 heme biosynthetic process The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01022426001 20057774 20077418 GO:0006779 porphyrin biosynthetic process The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01022426001 20057774 20077418 GO:0006783 heme biosynthetic process The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01024605001 8496603 8498137 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01002472001 34935887 34943673 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01002472001 34935887 34943673 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01002472001 34935887 34943673 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01002472001 34935887 34943673 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015690001 15629157 15629537 GSVIVG01010748001 22095735 22103188 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01010748001 22095735 22103188 GO:0006284 base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01010748001 22095735 22103188 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010748001 22095735 22103188 GO:0006284 base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010748001 22095735 22103188 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. IEA GO:0004519 endonuclease activity GSVIVG01010748001 22095735 22103188 GO:0006284 base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. IEA GO:0004519 endonuclease activity GSVIVG01010748001 22095735 22103188 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051539 4 iron, 4 sulfur cluster binding GSVIVG01010748001 22095735 22103188 GO:0006284 base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. IEA Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051539 4 iron, 4 sulfur cluster binding GSVIVG01029904001 1264732 1266568 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01001735001 644239 644787 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001735001 644239 644787 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01001735001 644239 644787 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01035141001 1800760 1805109 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01035141001 1800760 1805109 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01026916001 19416274 19418296 GSVIVG01036431001 5062047 5072425 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01036431001 5062047 5072425 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01036431001 5062047 5072425 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01036431001 5062047 5072425 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001208001 786079 787383 GSVIVG01011216001 9570316 9583713 GSVIVG01024178001 574481 578938 GSVIVG01027680001 14396699 14399661 GSVIVG01031775001 4272693 4276413 GSVIVG01014480001 4296664 4298294 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA GSVIVG01035132001 1710651 1716408 GSVIVG01019440001 706022 708527 GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA GSVIVG01020448001 19247390 19265696 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01020448001 19247390 19265696 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01037268001 16691129 16701724 GSVIVG01036751001 23001165 23010177 GO:0006006 glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01036751001 23001165 23010177 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01036751001 23001165 23010177 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01036751001 23001165 23010177 GO:0006006 glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. IEA Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+. IEA GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity GSVIVG01036751001 23001165 23010177 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+. IEA GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity GSVIVG01036751001 23001165 23010177 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+. IEA GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity GSVIVG01036751001 23001165 23010177 GO:0006006 glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01036751001 23001165 23010177 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01036751001 23001165 23010177 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01036751001 23001165 23010177 GO:0006006 glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. IEA Catalysis of the reaction: glyceraldehyde 3-phosphate + (phosphate / H2O) + NAD(P)+ = (3-phospho-D-glyceroyl-phosphate / 3-phospho-D-glycerate) + NAD(P)H + H+. IEA GO:0008943 glyceraldehyde-3-phosphate dehydrogenase activity GSVIVG01036751001 23001165 23010177 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: glyceraldehyde 3-phosphate + (phosphate / H2O) + NAD(P)+ = (3-phospho-D-glyceroyl-phosphate / 3-phospho-D-glycerate) + NAD(P)H + H+. IEA GO:0008943 glyceraldehyde-3-phosphate dehydrogenase activity GSVIVG01036751001 23001165 23010177 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: glyceraldehyde 3-phosphate + (phosphate / H2O) + NAD(P)+ = (3-phospho-D-glyceroyl-phosphate / 3-phospho-D-glycerate) + NAD(P)H + H+. IEA GO:0008943 glyceraldehyde-3-phosphate dehydrogenase activity GSVIVG01036751001 23001165 23010177 GO:0006006 glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01036751001 23001165 23010177 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01036751001 23001165 23010177 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01014456001 3938938 3941145 GSVIVG01030142001 10201805 10205357 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01030142001 10201805 10205357 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030142001 10201805 10205357 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01009459001 8544586 8547554 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01025320001 2062987 2071222 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01038651001 21201381 21203927 GSVIVG01025586001 13860469 13862418 GSVIVG01012083001 1572793 1582311 GO:0051260 protein homooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the removal of a phosphate group from phosphorylated myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol. IEA GO:0004437 inositol or phosphatidylinositol phosphatase activity GSVIVG01031164001 1580383 1582176 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Stops, prevents or reduces the activity of an enzyme. IEA GO:0004857 enzyme inhibitor activity GSVIVG01031164001 1580383 1582176 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the reaction: pectin + n H2O = n methanol + pectate. IEA GO:0030599 pectinesterase activity GSVIVG01001979001 5992672 5995863 Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01017201001 5281157 5294157 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01017201001 5281157 5294157 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017201001 5281157 5294157 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01017201001 5281157 5294157 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01021776001 10946041 10946529 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036835001 17738305 17740132 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and carries out proton transport across a membrane. The proton-transporting domain (F0, V0, or A0) includes integral and peripheral membrane proteins. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01036835001 17738305 17740132 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033179 proton-transporting V-type ATPase, V0 domain A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01021089001 1349455 1356941 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01021089001 1349455 1356941 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01021089001 1349455 1356941 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01021089001 1349455 1356941 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01021089001 1349455 1356941 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01021089001 1349455 1356941 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01021089001 1349455 1356941 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01021089001 1349455 1356941 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024892001 6206686 6208292 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024892001 6206686 6208292 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024892001 6206686 6208292 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024892001 6206686 6208292 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024892001 6206686 6208292 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024892001 6206686 6208292 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024892001 6206686 6208292 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01024892001 6206686 6208292 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01024892001 6206686 6208292 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01024892001 6206686 6208292 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024892001 6206686 6208292 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024892001 6206686 6208292 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031258001 736905 743063 GSVIVG01020534001 4731854 4734188 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008860001 2877304 2880161 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031453001 18341077 18344322 GSVIVG01026982001 18836126 18839407 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01026982001 18836126 18839407 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01026982001 18836126 18839407 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01026982001 18836126 18839407 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008850001 2802828 2805264 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01008850001 2802828 2805264 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01026232001 14529449 14529898 GSVIVG01033729001 18292879 18294427 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01033729001 18292879 18294427 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01033729001 18292879 18294427 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). IEA GO:0003755 peptidyl-prolyl cis-trans isomerase activity GSVIVG01033729001 18292879 18294427 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). IEA GO:0003755 peptidyl-prolyl cis-trans isomerase activity GSVIVG01033729001 18292879 18294427 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01033729001 18292879 18294427 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01033729001 18292879 18294427 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01033729001 18292879 18294427 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01033729001 18292879 18294427 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033729001 18292879 18294427 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033729001 18292879 18294427 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. IEA GO:0016853 isomerase activity GSVIVG01033729001 18292879 18294427 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. IEA GO:0016853 isomerase activity GSVIVG01033063001 25479103 25481683 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01033063001 25479103 25481683 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01033063001 25479103 25481683 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01033063001 25479103 25481683 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01033063001 25479103 25481683 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01033063001 25479103 25481683 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01021327001 4076654 4079490 GSVIVG01003665001 11920185 11930425 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other. IEA GO:0005337 nucleoside transmembrane transporter activity GSVIVG01017294001 6441403 6442569 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01017294001 6441403 6442569 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01017294001 6441403 6442569 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01038304001 12511463 12519979 GSVIVG01010907001 15875996 15876420 GSVIVG01021958001 5082995 5087974 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01021958001 5082995 5087974 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01021958001 5082995 5087974 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01021958001 5082995 5087974 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01021958001 5082995 5087974 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01021958001 5082995 5087974 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01021958001 5082995 5087974 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01021958001 5082995 5087974 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01021958001 5082995 5087974 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01021958001 5082995 5087974 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01021958001 5082995 5087974 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01021958001 5082995 5087974 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01021958001 5082995 5087974 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021958001 5082995 5087974 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021958001 5082995 5087974 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021958001 5082995 5087974 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01021958001 5082995 5087974 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01021958001 5082995 5087974 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01024214001 173840 177946 Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum. IEA GO:0003993 acid phosphatase activity GSVIVG01024214001 173840 177946 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01024214001 173840 177946 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01026838001 20074338 20079735 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026838001 20074338 20079735 GO:0019307 mannose biosynthetic process The chemical reactions and pathways resulting in the formation of mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026838001 20074338 20079735 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: D-mannose 1-phosphate = D-mannose 6-phosphate. IEA GO:0004615 phosphomannomutase activity GSVIVG01026838001 20074338 20079735 GO:0019307 mannose biosynthetic process The chemical reactions and pathways resulting in the formation of mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: D-mannose 1-phosphate = D-mannose 6-phosphate. IEA GO:0004615 phosphomannomutase activity GSVIVG01018622001 12106453 12109166 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the reaction: pectin + n H2O = n methanol + pectate. IEA GO:0030599 pectinesterase activity GSVIVG01030516001 6406216 6418944 GSVIVG01000290001 2379078 2380472 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01000290001 2379078 2380472 Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium. IEA GO:0005544 calcium-dependent phospholipid binding GSVIVG01036307001 3653922 3657395 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01011029001 2095642 2096286 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01011029001 2095642 2096286 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01011029001 2095642 2096286 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01011029001 2095642 2096286 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01011029001 2095642 2096286 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01011029001 2095642 2096286 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01006212001 23719941 23720339 GO:0008380 RNA splicing The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA GSVIVG01023021001 16780058 16825718 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01010867001 16692847 16719507 GSVIVG01018860001 19153005 19160933 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01018860001 19153005 19160933 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01007911001 7636532 7658790 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01007911001 7636532 7658790 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01007911001 7636532 7658790 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01007911001 7636532 7658790 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007911001 7636532 7658790 Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01007911001 7636532 7658790 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01026979001 18870784 18872229 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01026979001 18870784 18872229 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01026979001 18870784 18872229 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01021113001 1562230 1582041 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01021113001 1562230 1582041 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01021113001 1562230 1582041 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01021113001 1562230 1582041 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01021113001 1562230 1582041 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01021113001 1562230 1582041 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01011032001 2086300 2087833 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01011032001 2086300 2087833 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01023958001 2141138 2162161 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01023958001 2141138 2162161 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01023958001 2141138 2162161 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01023958001 2141138 2162161 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01023958001 2141138 2162161 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01023958001 2141138 2162161 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01023958001 2141138 2162161 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023958001 2141138 2162161 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023958001 2141138 2162161 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. IEA GO:0016597 amino acid binding GSVIVG01023958001 2141138 2162161 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. IEA GO:0016597 amino acid binding GSVIVG01027868001 8796212 8801998 GSVIVG01019217001 3216645 3241459 GSVIVG01020728001 2619611 2629896 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01020728001 2619611 2629896 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01020728001 2619611 2629896 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01020728001 2619611 2629896 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038034001 16557000 16569957 GO:0032968 positive regulation of RNA elongation from RNA polymerase II promoter Any process that activates or increases the frequency, rate or extent of RNA elongation, the extension of an RNA molecule after transcription initiation by the addition of ribonucleotides, catalyzed by RNA polymerase II. IEA Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule following transcription initiation. IEA GO:0003711 transcription elongation regulator activity GSVIVG01014424001 3624909 3626699 GSVIVG01014586001 5394486 5395614 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009654 oxygen evolving complex A complex, composed of a cluster of manganese, calcium and chloride ions bound to extrinsic proteins, that catalyzes the splitting of water to O2 and 4 H+. In cyanobacteria there are five extrinsic proteins in OEC (PsbO, PsbP-like, PsbQ-like, PsbU and PsbV), while in plants there are only three (PsbO, PsbP and PsbQ). IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01014586001 5394486 5395614 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0019898 extrinsic to membrane Loosely bound to one surface of a membrane, but not integrated into the hydrophobic region. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01016559001 2779762 2784769 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016559001 2779762 2784769 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: D-glyceraldehyde 3-phosphate = glycerone phosphate. IEA GO:0004807 triose-phosphate isomerase activity GSVIVG01016559001 2779762 2784769 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. IEA GO:0016853 isomerase activity GSVIVG01026631001 20891376 20894224 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026631001 20891376 20894224 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026631001 20891376 20894224 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026631001 20891376 20894224 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026631001 20891376 20894224 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01026631001 20891376 20894224 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01026631001 20891376 20894224 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01026631001 20891376 20894224 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01026631001 20891376 20894224 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01026631001 20891376 20894224 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01031523001 17681979 17691346 GSVIVG01015142001 1333934 1337765 GSVIVG01022201001 17411906 17416159 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01022201001 17411906 17416159 Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. IEA GO:0008483 transaminase activity GSVIVG01022201001 17411906 17416159 Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01015594001 5338362 5365561 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01029861001 669745 683491 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029861001 669745 683491 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01021702001 9772285 9773600 GSVIVG01027887001 9051147 9055240 GSVIVG01014198001 1391461 1393290 GSVIVG01031018001 21006105 21009498 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01031018001 21006105 21009498 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01030118001 10005704 10009044 GSVIVG01010471001 20870539 20876551 GO:0006909 phagocytosis The process whereby phagocytes engulf external particulate material. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles. IEA GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA GSVIVG01024578001 8664971 8669192 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01024578001 8664971 8669192 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01024578001 8664971 8669192 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01024578001 8664971 8669192 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037689001 6896418 6898875 GSVIVG01020110001 10259338 10260965 GSVIVG01023002001 17072717 17073492 Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01023002001 17072717 17073492 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01010282001 18955322 18986890 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01010282001 18955322 18986890 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01010282001 18955322 18986890 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01010282001 18955322 18986890 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032437001 27398336 27412009 GO:0006102 isocitrate metabolic process The chemical reactions and pathways involving isocitrate, the anion of isocitric acid, 1-hydroxy-1,2,3-propanetricarboxylic acid. Isocitrate is an important intermediate in the TCA cycle and the glycoxylate cycle. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01032437001 27398336 27412009 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01032437001 27398336 27412009 GO:0006102 isocitrate metabolic process The chemical reactions and pathways involving isocitrate, the anion of isocitric acid, 1-hydroxy-1,2,3-propanetricarboxylic acid. Isocitrate is an important intermediate in the TCA cycle and the glycoxylate cycle. IEA Catalysis of the reaction: isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH + H+. IEA GO:0004450 isocitrate dehydrogenase (NADP+) activity GSVIVG01032437001 27398336 27412009 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH + H+. IEA GO:0004450 isocitrate dehydrogenase (NADP+) activity GSVIVG01032437001 27398336 27412009 GO:0006102 isocitrate metabolic process The chemical reactions and pathways involving isocitrate, the anion of isocitric acid, 1-hydroxy-1,2,3-propanetricarboxylic acid. Isocitrate is an important intermediate in the TCA cycle and the glycoxylate cycle. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01032437001 27398336 27412009 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01032437001 27398336 27412009 GO:0006102 isocitrate metabolic process The chemical reactions and pathways involving isocitrate, the anion of isocitric acid, 1-hydroxy-1,2,3-propanetricarboxylic acid. Isocitrate is an important intermediate in the TCA cycle and the glycoxylate cycle. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01032437001 27398336 27412009 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01026516001 22359047 22359457 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01019056001 17272094 17283855 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019056001 17272094 17283855 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019056001 17272094 17283855 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019056001 17272094 17283855 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019056001 17272094 17283855 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01019056001 17272094 17283855 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01019056001 17272094 17283855 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01019056001 17272094 17283855 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01019056001 17272094 17283855 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019056001 17272094 17283855 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019056001 17272094 17283855 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019056001 17272094 17283855 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019056001 17272094 17283855 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01019056001 17272094 17283855 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01019056001 17272094 17283855 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01019056001 17272094 17283855 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01019056001 17272094 17283855 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01019056001 17272094 17283855 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01019056001 17272094 17283855 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01019056001 17272094 17283855 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01019056001 17272094 17283855 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01019056001 17272094 17283855 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01019056001 17272094 17283855 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01019056001 17272094 17283855 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01000994001 11229138 11229604 GSVIVG01017736001 3014205 3018323 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01017736001 3014205 3018323 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01017736001 3014205 3018323 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01035860001 4971042 4974625 GSVIVG01025047001 5021172 5031333 GO:0006011 UDP-glucose metabolic process The chemical reactions and pathways involving UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025047001 5021172 5031333 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025047001 5021172 5031333 GO:0006011 UDP-glucose metabolic process The chemical reactions and pathways involving UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025047001 5021172 5031333 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025047001 5021172 5031333 GO:0006011 UDP-glucose metabolic process The chemical reactions and pathways involving UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025047001 5021172 5031333 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025047001 5021172 5031333 GO:0006011 UDP-glucose metabolic process The chemical reactions and pathways involving UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate in the presence of single- or double-stranded DNA; drives another reaction. IEA GO:0008094 DNA-dependent ATPase activity GSVIVG01025047001 5021172 5031333 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate in the presence of single- or double-stranded DNA; drives another reaction. IEA GO:0008094 DNA-dependent ATPase activity GSVIVG01025047001 5021172 5031333 GO:0006011 UDP-glucose metabolic process The chemical reactions and pathways involving UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01025047001 5021172 5031333 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01017206001 5411821 5412753 GSVIVG01013207001 6707243 6711024 GSVIVG01008531001 1060849 1062387 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01008531001 1060849 1062387 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01008531001 1060849 1062387 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01008531001 1060849 1062387 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01017111001 4251158 4253233 GSVIVG01018042001 5754362 5770514 GSVIVG01033327001 21442402 21462940 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01033327001 21442402 21462940 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01033327001 21442402 21462940 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01014263001 2114581 2119163 GSVIVG01033869001 17136949 17140624 GSVIVG01028828001 18315825 18317281 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028828001 18315825 18317281 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01001134001 22886259 22887162 GSVIVG01019956001 12404356 12404707 GSVIVG01024649001 8036772 8040225 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01006304001 24761069 24766714 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01006304001 24761069 24766714 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01032845001 304818 309253 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. IEA GO:0004969 histamine receptor activity GSVIVG01032845001 304818 309253 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030130 clathrin coat of trans-Golgi network vesicle A clathrin coat found on a vesicle of the trans-Golgi network. IEA Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. IEA GO:0004969 histamine receptor activity GSVIVG01032845001 304818 309253 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030132 clathrin coat of coated pit The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex. IEA Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. IEA GO:0004969 histamine receptor activity GSVIVG01032845001 304818 309253 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. IEA GO:0004969 histamine receptor activity GSVIVG01032845001 304818 309253 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030130 clathrin coat of trans-Golgi network vesicle A clathrin coat found on a vesicle of the trans-Golgi network. IEA Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. IEA GO:0004969 histamine receptor activity GSVIVG01032845001 304818 309253 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030132 clathrin coat of coated pit The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex. IEA Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. IEA GO:0004969 histamine receptor activity GSVIVG01032845001 304818 309253 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. IEA GO:0004969 histamine receptor activity GSVIVG01032845001 304818 309253 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030130 clathrin coat of trans-Golgi network vesicle A clathrin coat found on a vesicle of the trans-Golgi network. IEA Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. IEA GO:0004969 histamine receptor activity GSVIVG01032845001 304818 309253 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030132 clathrin coat of coated pit The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex. IEA Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. IEA GO:0004969 histamine receptor activity GSVIVG01032845001 304818 309253 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01032845001 304818 309253 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030130 clathrin coat of trans-Golgi network vesicle A clathrin coat found on a vesicle of the trans-Golgi network. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01032845001 304818 309253 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030132 clathrin coat of coated pit The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01032845001 304818 309253 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01032845001 304818 309253 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030130 clathrin coat of trans-Golgi network vesicle A clathrin coat found on a vesicle of the trans-Golgi network. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01032845001 304818 309253 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030132 clathrin coat of coated pit The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01032845001 304818 309253 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01032845001 304818 309253 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030130 clathrin coat of trans-Golgi network vesicle A clathrin coat found on a vesicle of the trans-Golgi network. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01032845001 304818 309253 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030132 clathrin coat of coated pit The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01032845001 304818 309253 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032845001 304818 309253 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030130 clathrin coat of trans-Golgi network vesicle A clathrin coat found on a vesicle of the trans-Golgi network. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032845001 304818 309253 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030132 clathrin coat of coated pit The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032845001 304818 309253 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032845001 304818 309253 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030130 clathrin coat of trans-Golgi network vesicle A clathrin coat found on a vesicle of the trans-Golgi network. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032845001 304818 309253 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030132 clathrin coat of coated pit The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032845001 304818 309253 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032845001 304818 309253 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030130 clathrin coat of trans-Golgi network vesicle A clathrin coat found on a vesicle of the trans-Golgi network. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032845001 304818 309253 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030132 clathrin coat of coated pit The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035310001 299266 314682 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01035310001 299266 314682 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010131001 15950500 15952634 GSVIVG01016902001 2402507 2403817 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01016902001 2402507 2403817 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01023474001 11300355 11302580 GSVIVG01011162001 7561714 7570372 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01011162001 7561714 7570372 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01033881001 17047502 17048579 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01033881001 17047502 17048579 Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GSVIVG01033881001 17047502 17048579 Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01033881001 17047502 17048579 Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01021926001 5503839 5508879 GSVIVG01009933001 12525881 12526911 GSVIVG01013564001 20953222 20959005 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01013564001 20953222 20959005 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01013564001 20953222 20959005 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01013564001 20953222 20959005 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037055001 8315152 8316025 GO:0008283 cell proliferation The multiplication or reproduction of cells, resulting in the expansion of a cell population. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation. IEA GO:0008083 growth factor activity GSVIVG01034874001 15160583 15161347 GSVIVG01027208001 18256117 18264824 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01027208001 18256117 18264824 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01027208001 18256117 18264824 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01027208001 18256117 18264824 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01025266001 2592275 2596221 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + Na+(out) = amino acid(in) + Na+(in). IEA GO:0005283 sodium:amino acid symporter activity GSVIVG01025266001 2592275 2596221 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + Na+(out) = amino acid(in) + Na+(in). IEA GO:0005283 sodium:amino acid symporter activity GSVIVG01025266001 2592275 2596221 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + Na+(out) = amino acid(in) + Na+(in). IEA GO:0005283 sodium:amino acid symporter activity GSVIVG01025266001 2592275 2596221 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01025266001 2592275 2596221 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01025266001 2592275 2596221 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01025266001 2592275 2596221 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01025266001 2592275 2596221 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01025266001 2592275 2596221 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01011925001 2958067 2959131 GSVIVG01008685001 1204153 1214765 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01008685001 1204153 1214765 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01008685001 1204153 1214765 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01008685001 1204153 1214765 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008685001 1204153 1214765 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007955001 7223830 7226865 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01007955001 7223830 7226865 Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. IEA GO:0004519 endonuclease activity GSVIVG01017537001 10143081 10144079 GSVIVG01036653001 19896209 19898132 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01036653001 19896209 19898132 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01036653001 19896209 19898132 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01036653001 19896209 19898132 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01036653001 19896209 19898132 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01036653001 19896209 19898132 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01017338001 6866970 6868404 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01018703001 10962793 10962963 GO:0022904 respiratory electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01018703001 10962793 10962963 GO:0022904 respiratory electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01028234001 4819895 4828095 GSVIVG01009766001 11125765 11129338 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01009766001 11125765 11129338 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01009766001 11125765 11129338 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli. IEA GO:0004707 MAP kinase activity GSVIVG01009766001 11125765 11129338 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038169001 24041779 24042285 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01038169001 24041779 24042285 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01038169001 24041779 24042285 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027625001 14939020 14940681 GSVIVG01026864001 19813144 19822359 GSVIVG01005053001 17731145 17732430 GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA GSVIVG01022295001 18301941 18302822 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01003612001 11253371 11256035 GSVIVG01037364001 15005234 15008378 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01027645001 14718053 14719849 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01025795001 11783698 11788357 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01003199001 7799498 7802419 GSVIVG01035222001 10795507 10796386 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. IEA GO:0004364 glutathione transferase activity GSVIVG01037782001 7815548 7820515 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01037782001 7815548 7820515 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01037782001 7815548 7820515 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01024445001 2641404 2650986 GSVIVG01010797001 22669085 22679702 GSVIVG01027482001 16427686 16430024 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01032580001 28558850 28561295 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032580001 28558850 28561295 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01032041001 23265425 23268010 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01032041001 23265425 23268010 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01022705001 15324020 15326013 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. IEA GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GSVIVG01022901001 18178939 18179555 Functions in the storage of nutritious substrates. IEA GO:0045735 nutrient reservoir activity GSVIVG01009967001 12900789 12904974 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030134001 10130090 10132198 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01037817001 7537270 7559624 GSVIVG01006275001 24415592 24430679 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01007687001 10382198 10392948 GSVIVG01030694001 13705587 13710619 GSVIVG01034505001 20207847 20209652 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01012622001 132655 133302 GSVIVG01010630001 15832474 15832968 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01010630001 15832474 15832968 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01034998001 788238 792303 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. IEA GO:0008080 N-acetyltransferase activity GSVIVG01034769001 21169096 21176300 GSVIVG01010991001 2380228 2383593 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01011423001 29546270 29550223 GSVIVG01009064001 4643358 4644386 GSVIVG01008632001 260726 263753 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004185 serine-type carboxypeptidase activity GSVIVG01024357001 1371803 1398377 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01024357001 1371803 1398377 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01024357001 1371803 1398377 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01024357001 1371803 1398377 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01026903001 19528135 19544808 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01026903001 19528135 19544808 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01026903001 19528135 19544808 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026903001 19528135 19544808 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026903001 19528135 19544808 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01026903001 19528135 19544808 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01010276001 18753620 18764461 GSVIVG01008450001 1900870 1903798 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008450001 1900870 1903798 GO:0019318 hexose metabolic process The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008450001 1900870 1903798 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. IEA GO:0016853 isomerase activity GSVIVG01008450001 1900870 1903798 GO:0019318 hexose metabolic process The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule. IEA Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. IEA GO:0016853 isomerase activity GSVIVG01008450001 1900870 1903798 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01008450001 1900870 1903798 GO:0019318 hexose metabolic process The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule. IEA Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01023280001 20187203 20189657 GSVIVG01015841001 18171437 18173096 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015841001 18171437 18173096 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023240001 20766027 20769413 GSVIVG01008919001 3389497 3394322 GSVIVG01023889001 2647251 2657766 GSVIVG01021303001 3730147 3738385 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01021303001 3730147 3738385 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01021303001 3730147 3738385 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01021303001 3730147 3738385 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01021303001 3730147 3738385 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01021303001 3730147 3738385 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01021303001 3730147 3738385 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01021303001 3730147 3738385 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01021303001 3730147 3738385 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01029533001 21885971 21897453 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0009379 Holliday junction helicase complex A DNA helicase complex that forms part of a Holliday junction resolvase complex, where the helicase activity is involved in the migration of the junction branch point. The best-characterized example is the E. coli RuvAB complex, in which a hexamer of RuvB subunits possesses helicase activity that is modulated by association with RuvA . IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029533001 21885971 21897453 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA GO:0009379 Holliday junction helicase complex A DNA helicase complex that forms part of a Holliday junction resolvase complex, where the helicase activity is involved in the migration of the junction branch point. The best-characterized example is the E. coli RuvAB complex, in which a hexamer of RuvB subunits possesses helicase activity that is modulated by association with RuvA . IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029533001 21885971 21897453 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0009379 Holliday junction helicase complex A DNA helicase complex that forms part of a Holliday junction resolvase complex, where the helicase activity is involved in the migration of the junction branch point. The best-characterized example is the E. coli RuvAB complex, in which a hexamer of RuvB subunits possesses helicase activity that is modulated by association with RuvA . IEA Catalysis of the unwinding of the DNA helix of DNA containing four-way junctions, including Holliday junctions. IEA GO:0009378 four-way junction helicase activity GSVIVG01029533001 21885971 21897453 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA GO:0009379 Holliday junction helicase complex A DNA helicase complex that forms part of a Holliday junction resolvase complex, where the helicase activity is involved in the migration of the junction branch point. The best-characterized example is the E. coli RuvAB complex, in which a hexamer of RuvB subunits possesses helicase activity that is modulated by association with RuvA . IEA Catalysis of the unwinding of the DNA helix of DNA containing four-way junctions, including Holliday junctions. IEA GO:0009378 four-way junction helicase activity GSVIVG01038698001 20871741 20872052 GSVIVG01014277001 2279864 2280893 GSVIVG01021352001 4360092 4361177 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033017001 25084968 25088507 GSVIVG01032044001 23255671 23259082 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01028325001 6165838 6174860 GSVIVG01000835001 2694816 2720126 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01000835001 2694816 2720126 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01000949001 22202981 22211903 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01037234001 17082487 17083358 GSVIVG01011455001 29779429 29780859 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01015788001 17461171 17461983 GSVIVG01016648001 56559 59795 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01016648001 56559 59795 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01016648001 56559 59795 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01016648001 56559 59795 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016648001 56559 59795 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014243001 1882745 1897497 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01014243001 1882745 1897497 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01007982001 6977309 6979211 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01034805001 21853930 21856504 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01022452001 3175610 3183151 GSVIVG01017199001 5271187 5271839 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01017767001 3279943 3300085 GSVIVG01033723001 18335899 18342508 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01015668001 15262808 15265152 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025962001 26556666 26557112 GO:0006094 gluconeogenesis The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. IEA Catalysis of the reaction: D-glucose 6-phosphate = D-fructose 6-phosphate. IEA GO:0004347 glucose-6-phosphate isomerase activity GSVIVG01025962001 26556666 26557112 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the reaction: D-glucose 6-phosphate = D-fructose 6-phosphate. IEA GO:0004347 glucose-6-phosphate isomerase activity GSVIVG01011676001 5314009 5314665 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA GSVIVG01011676001 5314009 5314665 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01033453001 20562778 20572390 GSVIVG01009731001 10844298 10846184 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009731001 10844298 10846184 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009731001 10844298 10846184 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01009731001 10844298 10846184 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01009731001 10844298 10846184 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01009731001 10844298 10846184 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01033518001 20064408 20066523 GSVIVG01007781001 9097091 9098131 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01021520001 6527112 6532461 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021520001 6527112 6532461 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021520001 6527112 6532461 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0010181 FMN binding GSVIVG01021520001 6527112 6532461 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0010181 FMN binding GSVIVG01021520001 6527112 6532461 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021520001 6527112 6532461 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021774001 10910793 10913186 GSVIVG01008589001 592604 596839 GO:0033014 tetrapyrrole biosynthetic process The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008589001 592604 596839 GO:0033014 tetrapyrrole biosynthetic process The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. IEA Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. IEA GO:0008483 transaminase activity GSVIVG01008589001 592604 596839 GO:0033014 tetrapyrrole biosynthetic process The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01008589001 592604 596839 GO:0033014 tetrapyrrole biosynthetic process The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. IEA Catalysis of the reaction: (S)-4-amino-5-oxopentanoate = 5-aminolevulinate. IEA GO:0042286 glutamate-1-semialdehyde 2,1-aminomutase activity GSVIVG01000677001 15302580 15303331 GSVIVG01025560001 14061950 14062298 GSVIVG01011042001 2020369 2022497 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000324001 11383641 11387602 GSVIVG01033633001 19083201 19087938 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01033633001 19083201 19087938 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01033633001 19083201 19087938 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01033633001 19083201 19087938 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033633001 19083201 19087938 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01033633001 19083201 19087938 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01019365001 345981 346123 GSVIVG01036034001 7643369 7650501 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01036034001 7643369 7650501 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01036034001 7643369 7650501 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity. IEA GO:0004721 phosphoprotein phosphatase activity GSVIVG01036034001 7643369 7650501 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. IEA GO:0004722 protein serine/threonine phosphatase activity GSVIVG01036034001 7643369 7650501 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01036034001 7643369 7650501 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01028716001 19492844 19495932 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019420001 515903 519370 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019420001 515903 519370 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01023801001 3389326 3396811 GO:0031167 rRNA methylation The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01023801001 3389326 3396811 GO:0032259 methylation The process by which a methyl group is covalently attached to a molecule. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01023801001 3389326 3396811 GO:0031167 rRNA methylation The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01023801001 3389326 3396811 GO:0032259 methylation The process by which a methyl group is covalently attached to a molecule. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01032776001 838338 844898 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01000825001 2590513 2617294 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01000825001 2590513 2617294 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01000825001 2590513 2617294 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01000825001 2590513 2617294 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01000825001 2590513 2617294 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01000825001 2590513 2617294 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01000825001 2590513 2617294 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01000825001 2590513 2617294 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01000825001 2590513 2617294 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01000825001 2590513 2617294 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01031212001 1138843 1149038 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01031212001 1138843 1149038 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end. IEA GO:0008408 3'-5' exonuclease activity GSVIVG01000676001 15276858 15277884 GSVIVG01033647001 18951044 18957286 GSVIVG01032526001 28084182 28104340 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01032526001 28084182 28104340 Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters. IEA GO:0004523 ribonuclease H activity GSVIVG01014981001 13633965 13645604 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01014981001 13633965 13645604 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01014981001 13633965 13645604 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01014981001 13633965 13645604 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01017253001 5941898 5949575 GSVIVG01025444001 780383 784753 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of hydroxylation at the 7-methyl group of chlorophyllide a, according to the reactions: chlorophyllide a + O2 + NADPH + H+ = 7-hydroxychlorophyllide a + H2O + NADP+ and 7-hydroxychlorophyllide a + O2 + NADPH + H+ = chlorophyllide b + 2 H2O + NADP+. IEA GO:0010277 chlorophyllide a oxygenase activity GSVIVG01025444001 780383 784753 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025444001 780383 784753 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051537 2 iron, 2 sulfur cluster binding GSVIVG01015643001 14783387 14784221 GSVIVG01019363001 357536 363268 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01019363001 357536 363268 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01036042001 7749088 7758596 GSVIVG01035577001 2470501 2472631 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01035577001 2470501 2472631 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01035577001 2470501 2472631 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01035577001 2470501 2472631 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01011718001 4810479 4821442 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GSVIVG01011718001 4810479 4821442 GO:0009607 response to biotic stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism. IEA GSVIVG01019157001 15962927 15963850 GSVIVG01036995001 9139937 9145805 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01018051001 5812556 5816771 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01018051001 5812556 5816771 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01018051001 5812556 5816771 GO:0007131 reciprocal meiotic recombination The cell cycle process whereby double strand breaks are formed and repaired through a double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01018051001 5812556 5816771 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01018051001 5812556 5816771 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01018051001 5812556 5816771 GO:0007131 reciprocal meiotic recombination The cell cycle process whereby double strand breaks are formed and repaired through a double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01018051001 5812556 5816771 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01018051001 5812556 5816771 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01018051001 5812556 5816771 GO:0007131 reciprocal meiotic recombination The cell cycle process whereby double strand breaks are formed and repaired through a double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01018051001 5812556 5816771 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018051001 5812556 5816771 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018051001 5812556 5816771 GO:0007131 reciprocal meiotic recombination The cell cycle process whereby double strand breaks are formed and repaired through a double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018051001 5812556 5816771 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018051001 5812556 5816771 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018051001 5812556 5816771 GO:0007131 reciprocal meiotic recombination The cell cycle process whereby double strand breaks are formed and repaired through a double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018051001 5812556 5816771 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate in the presence of single- or double-stranded DNA; drives another reaction. IEA GO:0008094 DNA-dependent ATPase activity GSVIVG01018051001 5812556 5816771 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate in the presence of single- or double-stranded DNA; drives another reaction. IEA GO:0008094 DNA-dependent ATPase activity GSVIVG01018051001 5812556 5816771 GO:0007131 reciprocal meiotic recombination The cell cycle process whereby double strand breaks are formed and repaired through a double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate in the presence of single- or double-stranded DNA; drives another reaction. IEA GO:0008094 DNA-dependent ATPase activity GSVIVG01018051001 5812556 5816771 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01018051001 5812556 5816771 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01018051001 5812556 5816771 GO:0007131 reciprocal meiotic recombination The cell cycle process whereby double strand breaks are formed and repaired through a double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01016005001 17221411 17227998 GSVIVG01009880001 12073481 12076247 GSVIVG01032374001 26792210 26794366 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01008321001 3272925 3279659 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar. IEA GO:0008375 acetylglucosaminyltransferase activity GSVIVG01023585001 7656325 7659760 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01007752001 9583251 9590379 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007752001 9583251 9590379 GO:0008299 isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007752001 9583251 9590379 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007752001 9583251 9590379 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01007752001 9583251 9590379 GO:0008299 isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01007752001 9583251 9590379 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01007752001 9583251 9590379 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + NADPH + H+; catalyzes the formation of 2-C-methyl-D-erythritol from 1-deoxy-D-xylulose-5-phosphate as the second step in the non-mevalonate pathway for terpenoid synthesis. IEA GO:0030604 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity GSVIVG01007752001 9583251 9590379 GO:0008299 isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. IEA Catalysis of the reaction: 2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + NADPH + H+; catalyzes the formation of 2-C-methyl-D-erythritol from 1-deoxy-D-xylulose-5-phosphate as the second step in the non-mevalonate pathway for terpenoid synthesis. IEA GO:0030604 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity GSVIVG01007752001 9583251 9590379 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + NADPH + H+; catalyzes the formation of 2-C-methyl-D-erythritol from 1-deoxy-D-xylulose-5-phosphate as the second step in the non-mevalonate pathway for terpenoid synthesis. IEA GO:0030604 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity GSVIVG01007752001 9583251 9590379 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01007752001 9583251 9590379 GO:0008299 isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01007752001 9583251 9590379 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01029447001 22785960 22787669 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01015366001 3044618 3049194 GSVIVG01008936001 3586980 3587379 GSVIVG01010052001 13856923 13860657 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01010052001 13856923 13860657 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01010052001 13856923 13860657 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01010052001 13856923 13860657 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01010052001 13856923 13860657 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032117001 22516109 22524142 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01032117001 22516109 22524142 GO:0007047 cellular cell wall organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01032117001 22516109 22524142 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01032117001 22516109 22524142 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01032117001 22516109 22524142 GO:0007047 cellular cell wall organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01032117001 22516109 22524142 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01032117001 22516109 22524142 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01032117001 22516109 22524142 GO:0007047 cellular cell wall organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01032117001 22516109 22524142 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01009057001 4600963 4602556 Increases the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule. IEA GO:0019211 phosphatase activator activity GSVIVG01031937001 5563523 5567438 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01028646001 11535041 11547094 GSVIVG01023856001 2936108 2937432 GSVIVG01012777001 23420011 23421145 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01009126001 5310682 5314378 GO:0009734 auxin mediated signaling pathway The series of molecular signals generated in response to detection of auxin. ISS Interacting selectively and non-covalently with inositol hexakisphosphate. ISS GO:0000822 inositol hexakisphosphate binding GSVIVG01037077001 8069856 8072937 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01037077001 8069856 8072937 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01003352001 9260121 9277575 GO:0006367 transcription initiation from RNA polymerase II promoter A transcription initiation process that results in RNA synthesis by RNA polymerase II. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01003352001 9260121 9277575 GO:0045941 positive regulation of transcription Any cellular process that activates or increases the frequency, rate or extent of transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01003352001 9260121 9277575 GO:0006367 transcription initiation from RNA polymerase II promoter A transcription initiation process that results in RNA synthesis by RNA polymerase II. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Functions to initiate or regulate RNA polymerase II transcription. IEA GO:0003702 RNA polymerase II transcription factor activity GSVIVG01003352001 9260121 9277575 GO:0045941 positive regulation of transcription Any cellular process that activates or increases the frequency, rate or extent of transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Functions to initiate or regulate RNA polymerase II transcription. IEA GO:0003702 RNA polymerase II transcription factor activity GSVIVG01003352001 9260121 9277575 GO:0006367 transcription initiation from RNA polymerase II promoter A transcription initiation process that results in RNA synthesis by RNA polymerase II. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003352001 9260121 9277575 GO:0045941 positive regulation of transcription Any cellular process that activates or increases the frequency, rate or extent of transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003352001 9260121 9277575 GO:0006367 transcription initiation from RNA polymerase II promoter A transcription initiation process that results in RNA synthesis by RNA polymerase II. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01003352001 9260121 9277575 GO:0045941 positive regulation of transcription Any cellular process that activates or increases the frequency, rate or extent of transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01003352001 9260121 9277575 GO:0006367 transcription initiation from RNA polymerase II promoter A transcription initiation process that results in RNA synthesis by RNA polymerase II. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01003352001 9260121 9277575 GO:0045941 positive regulation of transcription Any cellular process that activates or increases the frequency, rate or extent of transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01003352001 9260121 9277575 GO:0006367 transcription initiation from RNA polymerase II promoter A transcription initiation process that results in RNA synthesis by RNA polymerase II. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any transcription regulator activity required for initiation or upregulation of transcription. IEA GO:0016563 transcription activator activity GSVIVG01003352001 9260121 9277575 GO:0045941 positive regulation of transcription Any cellular process that activates or increases the frequency, rate or extent of transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any transcription regulator activity required for initiation or upregulation of transcription. IEA GO:0016563 transcription activator activity GSVIVG01020638001 3586646 3588245 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01020638001 3586646 3588245 Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. IEA GO:0008171 O-methyltransferase activity GSVIVG01020638001 3586646 3588245 The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01012828001 5810508 5819805 GO:0006821 chloride transport The directed movement of chloride into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01012828001 5810508 5819805 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01012828001 5810508 5819805 GO:0006821 chloride transport The directed movement of chloride into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a chloride ion by a voltage-gated channel. IEA GO:0005247 voltage-gated chloride channel activity GSVIVG01012828001 5810508 5819805 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a chloride ion by a voltage-gated channel. IEA GO:0005247 voltage-gated chloride channel activity GSVIVG01003913001 13525223 13534547 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01003913001 13525223 13534547 GO:0006914 autophagy The process by which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01003913001 13525223 13534547 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01003913001 13525223 13534547 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01003913001 13525223 13534547 GO:0006914 autophagy The process by which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01003913001 13525223 13534547 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01003913001 13525223 13534547 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01003913001 13525223 13534547 GO:0006914 autophagy The process by which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01003913001 13525223 13534547 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01000518001 13572014 13572375 GSVIVG01013084001 8572997 8573383 GSVIVG01038798001 1168701 1177397 GSVIVG01036265001 7809362 7809565 GSVIVG01023232001 20849145 20896388 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01001319001 5284594 5287233 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01037211001 27929370 27938714 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01037211001 27929370 27938714 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01037211001 27929370 27938714 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01037983001 12043038 12058273 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01037983001 12043038 12058273 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01037983001 12043038 12058273 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01037983001 12043038 12058273 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01028951001 17152642 17152908 GSVIVG01015853001 18414317 18417667 GSVIVG01035207001 10470253 10475343 Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate. IEA GO:0008146 sulfotransferase activity GSVIVG01033255001 22149706 22155867 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01033255001 22149706 22155867 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01033255001 22149706 22155867 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01014772001 9488658 9491530 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01015463001 3916921 3928137 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01015463001 3916921 3928137 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01015463001 3916921 3928137 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01003360001 9353966 9354299 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01021078001 14028572 14031484 GO:0007050 cell cycle arrest The process by which the cell cycle is halted during one of the normal phases (G1, S, G2, M). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Stops, prevents or reduces the activity of a cyclin-dependent protein kinase. IEA GO:0004861 cyclin-dependent protein kinase inhibitor activity GSVIVG01022383001 19425901 19431562 GO:0007205 activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway The initiation of the activity of the inactive enzyme protein kinase C as the result of a series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol 3-phosphate. IEA GO:0004143 diacylglycerol kinase activity GSVIVG01034590001 14826542 14833239 GSVIVG01009584001 9649733 9656551 GSVIVG01026700001 5019078 5024683 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01026700001 5019078 5024683 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01026700001 5019078 5024683 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01026700001 5019078 5024683 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01026700001 5019078 5024683 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034898001 16218963 16221368 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01034898001 16218963 16221368 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01034898001 16218963 16221368 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01034898001 16218963 16221368 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor. IEA GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GSVIVG01034898001 16218963 16221368 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01024652001 8004947 8006625 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01024652001 8004947 8006625 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01024652001 8004947 8006625 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030776001 15765500 15804948 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01030776001 15765500 15804948 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01030776001 15765500 15804948 GO:0006420 arginyl-tRNA aminoacylation The process of coupling arginine to arginyl-tRNA, catalyzed by arginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01030776001 15765500 15804948 GO:0006438 valyl-tRNA aminoacylation The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01030776001 15765500 15804948 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01030776001 15765500 15804948 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01030776001 15765500 15804948 GO:0006420 arginyl-tRNA aminoacylation The process of coupling arginine to arginyl-tRNA, catalyzed by arginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01030776001 15765500 15804948 GO:0006438 valyl-tRNA aminoacylation The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01030776001 15765500 15804948 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). IEA GO:0004814 arginine-tRNA ligase activity GSVIVG01030776001 15765500 15804948 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). IEA GO:0004814 arginine-tRNA ligase activity GSVIVG01030776001 15765500 15804948 GO:0006420 arginyl-tRNA aminoacylation The process of coupling arginine to arginyl-tRNA, catalyzed by arginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). IEA GO:0004814 arginine-tRNA ligase activity GSVIVG01030776001 15765500 15804948 GO:0006438 valyl-tRNA aminoacylation The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). IEA GO:0004814 arginine-tRNA ligase activity GSVIVG01030776001 15765500 15804948 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val). IEA GO:0004832 valine-tRNA ligase activity GSVIVG01030776001 15765500 15804948 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val). IEA GO:0004832 valine-tRNA ligase activity GSVIVG01030776001 15765500 15804948 GO:0006420 arginyl-tRNA aminoacylation The process of coupling arginine to arginyl-tRNA, catalyzed by arginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val). IEA GO:0004832 valine-tRNA ligase activity GSVIVG01030776001 15765500 15804948 GO:0006438 valyl-tRNA aminoacylation The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val). IEA GO:0004832 valine-tRNA ligase activity GSVIVG01030776001 15765500 15804948 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030776001 15765500 15804948 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030776001 15765500 15804948 GO:0006420 arginyl-tRNA aminoacylation The process of coupling arginine to arginyl-tRNA, catalyzed by arginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030776001 15765500 15804948 GO:0006438 valyl-tRNA aminoacylation The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015175001 1579674 1583002 GSVIVG01023123001 22330130 22332495 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035235001 10914291 10921085 GSVIVG01003504001 10804161 10806174 GSVIVG01035710001 3503997 3512108 GO:0015746 citrate transport The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of arsenite from one side of a membrane to the other. IEA GO:0015105 arsenite transmembrane transporter activity GSVIVG01035710001 3503997 3512108 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of arsenite from one side of a membrane to the other. IEA GO:0015105 arsenite transmembrane transporter activity GSVIVG01035710001 3503997 3512108 GO:0015746 citrate transport The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, from one side of the membrane to the other. IEA GO:0015137 citrate transmembrane transporter activity GSVIVG01035710001 3503997 3512108 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, from one side of the membrane to the other. IEA GO:0015137 citrate transmembrane transporter activity GSVIVG01011626001 5786197 5797731 GSVIVG01016127001 19510685 19515435 GSVIVG01036884001 18277061 18278626 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01036884001 18277061 18278626 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01036884001 18277061 18278626 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01036884001 18277061 18278626 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025766001 12122749 12122961 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01025766001 12122749 12122961 GO:0006730 one-carbon metabolic process The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01025766001 12122749 12122961 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the reaction: ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine. IEA GO:0004478 methionine adenosyltransferase activity GSVIVG01025766001 12122749 12122961 GO:0006730 one-carbon metabolic process The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. IEA Catalysis of the reaction: ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine. IEA GO:0004478 methionine adenosyltransferase activity GSVIVG01025766001 12122749 12122961 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025766001 12122749 12122961 GO:0006730 one-carbon metabolic process The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007587001 11606489 11620317 GSVIVG01015491001 4178622 4183658 GSVIVG01033721001 18352790 18358484 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01033721001 18352790 18358484 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01033721001 18352790 18358484 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033721001 18352790 18358484 Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01026363001 15011615 15039726 GSVIVG01003315001 8980867 8995465 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01032029001 23366475 23371929 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01032029001 23366475 23371929 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: linoleate + O2 = (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate. IEA GO:0016165 lipoxygenase activity GSVIVG01032029001 23366475 23371929 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor. IEA GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen GSVIVG01032029001 23366475 23371929 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01012425001 635965 636195 GSVIVG01019538001 1445716 1451555 GSVIVG01020735001 2494842 2529932 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01020735001 2494842 2529932 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01020735001 2494842 2529932 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01020735001 2494842 2529932 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020735001 2494842 2529932 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000853001 3039331 3054933 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01000853001 3039331 3054933 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01000853001 3039331 3054933 GO:0042773 ATP synthesis coupled electron transport The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01000853001 3039331 3054933 GO:0042773 ATP synthesis coupled electron transport The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01000853001 3039331 3054933 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01000853001 3039331 3054933 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01000853001 3039331 3054933 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01000853001 3039331 3054933 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01000853001 3039331 3054933 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. IEA GO:0008137 NADH dehydrogenase (ubiquinone) activity GSVIVG01000853001 3039331 3054933 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. IEA GO:0008137 NADH dehydrogenase (ubiquinone) activity GSVIVG01000853001 3039331 3054933 GO:0042773 ATP synthesis coupled electron transport The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. IEA GO:0008137 NADH dehydrogenase (ubiquinone) activity GSVIVG01000853001 3039331 3054933 GO:0042773 ATP synthesis coupled electron transport The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. IEA GO:0008137 NADH dehydrogenase (ubiquinone) activity GSVIVG01000853001 3039331 3054933 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. IEA GO:0008137 NADH dehydrogenase (ubiquinone) activity GSVIVG01000853001 3039331 3054933 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. IEA GO:0008137 NADH dehydrogenase (ubiquinone) activity GSVIVG01000853001 3039331 3054933 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. IEA GO:0008137 NADH dehydrogenase (ubiquinone) activity GSVIVG01000853001 3039331 3054933 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. IEA GO:0008137 NADH dehydrogenase (ubiquinone) activity GSVIVG01000853001 3039331 3054933 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01000853001 3039331 3054933 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01000853001 3039331 3054933 GO:0042773 ATP synthesis coupled electron transport The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01000853001 3039331 3054933 GO:0042773 ATP synthesis coupled electron transport The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01000853001 3039331 3054933 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01000853001 3039331 3054933 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01000853001 3039331 3054933 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01000853001 3039331 3054933 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01015252001 2127173 2129065 GO:0000272 polysaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015252001 2127173 2129065 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015252001 2127173 2129065 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015252001 2127173 2129065 GO:0000272 polysaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages. IEA Catalysis of the hydrolysis of 1,4-alpha-glucosidic linkages in polysaccharides so as to remove successive maltose units from the non-reducing ends of the chains. IEA GO:0016161 beta-amylase activity GSVIVG01015252001 2127173 2129065 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of 1,4-alpha-glucosidic linkages in polysaccharides so as to remove successive maltose units from the non-reducing ends of the chains. IEA GO:0016161 beta-amylase activity GSVIVG01015252001 2127173 2129065 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the hydrolysis of 1,4-alpha-glucosidic linkages in polysaccharides so as to remove successive maltose units from the non-reducing ends of the chains. IEA GO:0016161 beta-amylase activity GSVIVG01015252001 2127173 2129065 GO:0000272 polysaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages. IEA Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). IEA GO:0016769 transferase activity, transferring nitrogenous groups GSVIVG01015252001 2127173 2129065 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). IEA GO:0016769 transferase activity, transferring nitrogenous groups GSVIVG01015252001 2127173 2129065 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). IEA GO:0016769 transferase activity, transferring nitrogenous groups GSVIVG01015252001 2127173 2129065 GO:0000272 polysaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01015252001 2127173 2129065 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01015252001 2127173 2129065 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01015252001 2127173 2129065 GO:0000272 polysaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01015252001 2127173 2129065 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01015252001 2127173 2129065 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01032239001 13588595 13606856 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012409001 532814 543606 GSVIVG01016924001 2621967 2622152 GSVIVG01002803001 36569511 36570825 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01006131001 41937222 41937601 GSVIVG01029939001 1784493 1796232 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01035571001 2391522 2397246 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01035571001 2391522 2397246 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01035571001 2391522 2397246 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01035571001 2391522 2397246 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035571001 2391522 2397246 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036211001 8947183 8968362 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01033711001 18415970 18425901 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033711001 18415970 18425901 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01023253001 20545986 20546727 GSVIVG01036778001 22673124 22674794 GSVIVG01014857001 10691450 10694026 GO:0051252 regulation of RNA metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA. IEA Stops, prevents or reduces the activity of a ribonuclease, any enzyme that catalyzes the hydrolysis of phosphodiester bonds in chains of RNA. IEA GO:0008428 ribonuclease inhibitor activity GSVIVG01033459001 20507385 20510673 GSVIVG01025992001 26187569 26190602 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017649001 2377860 2383123 GSVIVG01019686001 2451946 2468894 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01019686001 2451946 2468894 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01019686001 2451946 2468894 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01019686001 2451946 2468894 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01031393001 19174805 19180295 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008492001 1370139 1381495 GSVIVG01023862001 2913098 2918575 GSVIVG01028238001 4866937 4867868 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01016973001 3091180 3096452 Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01022874001 18505971 18523844 GO:0006546 glycine catabolic process The chemical reactions and pathways resulting in the breakdown of glycine, aminoethanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: (6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein = (6R)-5,10-methylenetetrahydrofolate + NH3 + dihydrolipoylprotein. IEA GO:0004047 aminomethyltransferase activity GSVIVG01019011001 17802191 17803264 GSVIVG01029139001 19269701 19269885 GSVIVG01017886001 4334243 4347479 GSVIVG01019204001 3521596 3521808 GSVIVG01036282001 7565507 7565731 GSVIVG01013172001 7180186 7183125 GSVIVG01026071001 24953936 24961708 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01026071001 24953936 24961708 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01008981001 4033185 4034494 GSVIVG01007444001 31957089 31983092 Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage. IEA GO:0016209 antioxidant activity GSVIVG01007444001 31957089 31983092 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021207001 2549343 2549744 GSVIVG01035556001 2271265 2281988 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01035556001 2271265 2281988 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007522001 12796714 12806173 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01033269001 21982983 21983544 GSVIVG01018007001 5426550 5436376 GSVIVG01020095001 10393877 10395532 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01020095001 10393877 10395532 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01020095001 10393877 10395532 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032781001 810932 816168 GSVIVG01020574001 4178065 4179294 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025740001 12352487 12357537 GSVIVG01020103001 10300523 10305820 GSVIVG01023969001 2054488 2055821 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01008308001 3407144 3414365 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01008308001 3407144 3414365 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01004748001 15896740 15915947 GSVIVG01027670001 14487855 14494216 GO:0009073 aromatic amino acid family biosynthetic process The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027670001 14487855 14494216 GO:0009073 aromatic amino acid family biosynthetic process The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. IEA GO:0003866 3-phosphoshikimate 1-carboxyvinyltransferase activity GSVIVG01027670001 14487855 14494216 GO:0009073 aromatic amino acid family biosynthetic process The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor). IEA GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups GSVIVG01016524001 3133444 3139642 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01032146001 22163152 22163565 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014042001 9914908 9918414 GSVIVG01022739001 15862417 15866141 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01016715001 561899 563052 GSVIVG01028246001 4908103 4912003 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01015794001 17496540 17497702 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01015794001 17496540 17497702 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024829001 6574877 6575254 GSVIVG01026910001 19454696 19457458 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01026910001 19454696 19457458 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01026910001 19454696 19457458 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026910001 19454696 19457458 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026910001 19454696 19457458 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01026910001 19454696 19457458 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01032599001 28745561 28754982 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032599001 28745561 28754982 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032599001 28745561 28754982 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032599001 28745561 28754982 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032599001 28745561 28754982 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032599001 28745561 28754982 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032599001 28745561 28754982 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032599001 28745561 28754982 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032599001 28745561 28754982 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032599001 28745561 28754982 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032599001 28745561 28754982 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032599001 28745561 28754982 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032599001 28745561 28754982 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01032599001 28745561 28754982 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01032599001 28745561 28754982 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01032599001 28745561 28754982 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01032599001 28745561 28754982 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01032599001 28745561 28754982 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01032599001 28745561 28754982 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01032599001 28745561 28754982 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01032599001 28745561 28754982 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01032599001 28745561 28754982 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01032599001 28745561 28754982 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01032599001 28745561 28754982 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01032599001 28745561 28754982 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01032599001 28745561 28754982 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01032599001 28745561 28754982 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01032599001 28745561 28754982 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01032599001 28745561 28754982 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01032599001 28745561 28754982 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01028155001 4265459 4271841 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018862001 19143417 19150304 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01018862001 19143417 19150304 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01018862001 19143417 19150304 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01018862001 19143417 19150304 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01018862001 19143417 19150304 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01018862001 19143417 19150304 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01018862001 19143417 19150304 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01018862001 19143417 19150304 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01018862001 19143417 19150304 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01018862001 19143417 19150304 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01018862001 19143417 19150304 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01018862001 19143417 19150304 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01018862001 19143417 19150304 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01018862001 19143417 19150304 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01018862001 19143417 19150304 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01018862001 19143417 19150304 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01018862001 19143417 19150304 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01018862001 19143417 19150304 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031752001 4054284 4059659 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01019033001 17553881 17555447 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01026863001 19822836 19824459 GSVIVG01003490001 10715320 10716703 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005267 potassium channel activity GSVIVG01031867001 4994799 5003359 GSVIVG01005191001 19014689 19018301 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01005191001 19014689 19018301 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01005191001 19014689 19018301 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. IEA GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GSVIVG01005191001 19014689 19018301 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species. IEA GO:0031418 L-ascorbic acid binding GSVIVG01002490001 35044541 35045681 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01002490001 35044541 35045681 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01002490001 35044541 35045681 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01002490001 35044541 35045681 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01002490001 35044541 35045681 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01002490001 35044541 35045681 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01002490001 35044541 35045681 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01002490001 35044541 35045681 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01002490001 35044541 35045681 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01002490001 35044541 35045681 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01002490001 35044541 35045681 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01002490001 35044541 35045681 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01018476001 14556508 14564323 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01018476001 14556508 14564323 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01018476001 14556508 14564323 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01018476001 14556508 14564323 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018476001 14556508 14564323 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01025391001 1143640 1150253 GSVIVG01027032001 18449117 18454203 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01027575001 15433755 15442222 GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. IEA GO:0005179 hormone activity GSVIVG01034008001 15940504 15943215 GSVIVG01036672001 20079978 20087873 GSVIVG01038616001 21450859 21454428 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: 6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate. IEA GO:0017057 6-phosphogluconolactonase activity GSVIVG01038616001 21450859 21454428 GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. IEA Catalysis of the reaction: 6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate. IEA GO:0017057 6-phosphogluconolactonase activity GSVIVG01037789001 7910839 7917664 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01037789001 7910839 7917664 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01037789001 7910839 7917664 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037789001 7910839 7917664 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037789001 7910839 7917664 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01037789001 7910839 7917664 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01037789001 7910839 7917664 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01037789001 7910839 7917664 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01037789001 7910839 7917664 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01037789001 7910839 7917664 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01011993001 2365383 2365923 GSVIVG01018591001 12649158 12649619 Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01018591001 12649158 12649619 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018591001 12649158 12649619 Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01018591001 12649158 12649619 Interacting selectively and non-covalently with thiamin pyrophosphate, the diphosphoric ester of thiamin. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases. IEA GO:0030976 thiamin pyrophosphate binding GSVIVG01026430001 23670969 23677028 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01026430001 23670969 23677028 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01026430001 23670969 23677028 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01026430001 23670969 23677028 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01038300001 12450273 12450996 GSVIVG01033591001 19477705 19481931 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01027324001 16602192 16602854 GSVIVG01035927001 6037925 6041003 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01035927001 6037925 6041003 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01026240001 14642106 14642708 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007660001 10759103 10765957 GSVIVG01002221001 33501917 33502819 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028053001 3461091 3467139 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01028053001 3461091 3467139 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01028053001 3461091 3467139 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. IEA GO:0000155 two-component sensor activity GSVIVG01028053001 3461091 3467139 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01028053001 3461091 3467139 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01028053001 3461091 3467139 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. IEA GO:0004673 protein histidine kinase activity GSVIVG01028053001 3461091 3467139 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01028053001 3461091 3467139 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01028053001 3461091 3467139 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01028053001 3461091 3467139 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028053001 3461091 3467139 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028053001 3461091 3467139 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028053001 3461091 3467139 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01028053001 3461091 3467139 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01028053001 3461091 3467139 GO:0018106 peptidyl-histidine phosphorylation The posttranslational phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01015592001 5303811 5305207 GSVIVG01006112001 41715845 41717418 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01006112001 41715845 41717418 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01006112001 41715845 41717418 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01006112001 41715845 41717418 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01021588001 7545885 7550309 GSVIVG01030458001 5734308 5760788 GSVIVG01009687001 10482381 10489343 GSVIVG01000541001 7268312 7270256 GSVIVG01011257001 10155970 10156994 GSVIVG01008327001 3220546 3228158 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01008327001 3220546 3228158 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01008327001 3220546 3228158 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01008327001 3220546 3228158 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013112001 8170641 8173950 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with damaged DNA. IEA GO:0003684 damaged DNA binding GSVIVG01013112001 8170641 8173950 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the degradation of double-stranded DNA. It acts progressively in a 3' to 5' direction, releasing 5'-phosphomononucleotides. IEA GO:0008853 exodeoxyribonuclease III activity GSVIVG01011966001 2536145 2541365 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. IEA GO:0004969 histamine receptor activity GSVIVG01011966001 2536145 2541365 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. IEA GO:0004969 histamine receptor activity GSVIVG01011966001 2536145 2541365 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. IEA GO:0005179 hormone activity GSVIVG01011966001 2536145 2541365 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. IEA GO:0005179 hormone activity GSVIVG01031524001 17649270 17652697 GSVIVG01016205001 6623609 6626913 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015934 large ribosomal subunit The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01034091001 15242234 15242272 GSVIVG01030972001 20081088 20081976 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015934 large ribosomal subunit The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01006165001 42326798 42328170 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01027307001 16901233 16912595 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027307001 16901233 16912595 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027307001 16901233 16912595 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027307001 16901233 16912595 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027307001 16901233 16912595 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01027307001 16901233 16912595 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01018777001 20011688 20015380 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01018777001 20011688 20015380 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01018777001 20011688 20015380 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA A ligand-dependent receptor found in the nucleus of the cell. IEA GO:0004879 ligand-dependent nuclear receptor activity GSVIVG01018777001 20011688 20015380 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA A ligand-dependent receptor found in the nucleus of the cell. IEA GO:0004879 ligand-dependent nuclear receptor activity GSVIVG01018777001 20011688 20015380 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01018777001 20011688 20015380 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01016778001 1271509 1282024 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01017724001 2943704 2952400 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01017724001 2943704 2952400 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017724001 2943704 2952400 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01017724001 2943704 2952400 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01017724001 2943704 2952400 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01004678001 39588970 39592698 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01020014001 11577724 11584830 GSVIVG01014057001 10171602 10174094 GSVIVG01025799001 11738050 11743239 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GSVIVG01035660001 3089690 3096666 GSVIVG01031558001 17992485 17997525 GSVIVG01010775001 22473907 22474206 GSVIVG01015903001 19106479 19108923 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01028796001 18741352 18742994 GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA GSVIVG01006041001 23410479 23422257 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01006041001 23410479 23422257 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01013971001 8183260 8183939 GSVIVG01004448001 38630466 38633736 GO:0006189 'de novo' IMP biosynthetic process The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate. IEA Catalysis of the reaction: 10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide. IEA GO:0004644 phosphoribosylglycinamide formyltransferase activity GSVIVG01004448001 38630466 38633736 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: 10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide. IEA GO:0004644 phosphoribosylglycinamide formyltransferase activity GSVIVG01004448001 38630466 38633736 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide. IEA GO:0004644 phosphoribosylglycinamide formyltransferase activity GSVIVG01004448001 38630466 38633736 GO:0006189 'de novo' IMP biosynthetic process The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01004448001 38630466 38633736 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01004448001 38630466 38633736 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01004448001 38630466 38633736 GO:0006189 'de novo' IMP biosynthetic process The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01004448001 38630466 38633736 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01004448001 38630466 38633736 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01004448001 38630466 38633736 GO:0006189 'de novo' IMP biosynthetic process The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate. IEA IEA GO:0016742 hydroxymethyl-, formyl- and related transferase activity GSVIVG01004448001 38630466 38633736 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA IEA GO:0016742 hydroxymethyl-, formyl- and related transferase activity GSVIVG01004448001 38630466 38633736 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA IEA GO:0016742 hydroxymethyl-, formyl- and related transferase activity GSVIVG01025075001 4759942 4760340 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025075001 4759942 4760340 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025075001 4759942 4760340 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01025075001 4759942 4760340 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01025075001 4759942 4760340 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01025075001 4759942 4760340 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01018083001 6332955 6340243 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01018083001 6332955 6340243 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01018083001 6332955 6340243 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01018083001 6332955 6340243 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01006302001 24748934 24752897 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01006302001 24748934 24752897 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01032532001 28141711 28146735 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion. IEA GO:0004806 triglyceride lipase activity GSVIVG01030331001 8767790 8774501 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01022115001 16707463 16710545 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate. IEA GO:0004629 phospholipase C activity GSVIVG01022115001 16707463 16710545 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. IEA GO:0008081 phosphoric diester hydrolase activity GSVIVG01014585001 5386845 5394439 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01014585001 5386845 5394439 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030643001 7386025 7390581 GO:0016043 cellular component organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cellular component. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01030643001 7386025 7390581 GO:0030036 actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01014748001 9168929 9178255 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GSVIVG01032163001 21937802 21944915 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01000142001 15603695 15605336 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GSVIVG01000142001 15603695 15605336 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GSVIVG01014115001 526730 528866 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014115001 526730 528866 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028451001 7787491 7797087 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01021752001 10522986 10538543 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01022321001 18468791 18471953 GSVIVG01022789001 16649840 16650046 GSVIVG01025365001 1429343 1431684 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01025365001 1429343 1431684 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01025365001 1429343 1431684 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01025365001 1429343 1431684 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01010466001 20818548 20820093 Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. IEA GO:0008171 O-methyltransferase activity GSVIVG01011240001 9988895 9990749 GO:0015671 oxygen transport The directed movement of oxygen (O2) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01011240001 9988895 9990749 GO:0015671 oxygen transport The directed movement of oxygen (O2) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with oxygen (O2). IEA GO:0019825 oxygen binding GSVIVG01011240001 9988895 9990749 GO:0015671 oxygen transport The directed movement of oxygen (O2) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01035238001 10997910 11025564 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035238001 10997910 11025564 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035238001 10997910 11025564 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01035238001 10997910 11025564 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01035238001 10997910 11025564 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01035238001 10997910 11025564 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01024898001 6172834 6173092 GSVIVG01015475001 4016054 4017076 GSVIVG01029046001 11354245 11374240 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01019670001 2347216 2348922 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01009166001 5668081 5668815 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01032362001 26715231 26732295 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01032362001 26715231 26732295 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01032362001 26715231 26732295 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01032362001 26715231 26732295 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01003487001 10680884 10681310 GSVIVG01000569001 6982614 6986592 GSVIVG01016148001 19788292 19790440 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01016148001 19788292 19790440 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01016148001 19788292 19790440 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01016148001 19788292 19790440 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01016148001 19788292 19790440 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01016148001 19788292 19790440 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01016148001 19788292 19790440 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01016148001 19788292 19790440 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01032557001 28346359 28358308 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01032557001 28346359 28358308 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032557001 28346359 28358308 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01029967001 2442720 2445710 GSVIVG01027243001 17686535 17689858 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01027243001 17686535 17689858 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01027243001 17686535 17689858 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027243001 17686535 17689858 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029426001 17077436 17089089 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01029426001 17077436 17089089 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01029426001 17077436 17089089 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024958001 5666788 5672334 GSVIVG01036176001 19787308 19791409 Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01036176001 19787308 19791409 Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01036176001 19787308 19791409 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01036176001 19787308 19791409 Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01032771001 886098 888154 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01032771001 886098 888154 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01032771001 886098 888154 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01032771001 886098 888154 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019890001 4251598 4260954 GSVIVG01014262001 2107497 2113818 GSVIVG01019060001 17237681 17249747 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01019060001 17237681 17249747 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01038573001 21768761 21771164 GSVIVG01030578001 6863293 6864210 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion. IEA GO:0005484 SNAP receptor activity GSVIVG01030578001 6863293 6864210 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion. IEA GO:0005484 SNAP receptor activity GSVIVG01030578001 6863293 6864210 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030578001 6863293 6864210 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000505001 15176777 15176976 GSVIVG01018548001 13519645 13520644 GO:0006725 cellular aromatic compound metabolic process The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells. IEA Interacting selectively and non-covalently with ferrous iron, Fe(II). IEA GO:0008198 ferrous iron binding GSVIVG01018548001 13519645 13520644 GO:0006725 cellular aromatic compound metabolic process The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01023266001 20417305 20424575 GSVIVG01023884001 2681129 2731911 GO:0030301 cholesterol transport The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with the hedgehog protein to initiate a change in cell activity. IEA GO:0008158 hedgehog receptor activity GSVIVG01023884001 2681129 2731911 GO:0030301 cholesterol transport The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with the hedgehog protein to initiate a change in cell activity. IEA GO:0008158 hedgehog receptor activity GSVIVG01024201001 373306 374140 GSVIVG01035075001 1304984 1305784 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GSVIVG01035075001 1304984 1305784 GO:0009607 response to biotic stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism. IEA GSVIVG01026192001 13766843 13771316 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01026192001 13766843 13771316 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01007272001 1200009 1208459 GO:0007585 respiratory gaseous exchange The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. IEA GO:0005740 mitochondrial envelope The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space. IEA GSVIVG01007272001 1200009 1208459 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005740 mitochondrial envelope The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space. IEA GSVIVG01020305001 21640042 21641684 GSVIVG01006088001 41277737 41278355 GO:0006725 cellular aromatic compound metabolic process The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells. IEA Interacting selectively and non-covalently with ferrous iron, Fe(II). IEA GO:0008198 ferrous iron binding GSVIVG01006088001 41277737 41278355 GO:0006725 cellular aromatic compound metabolic process The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01007237001 31005189 31015945 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01011853001 3565119 3569339 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01020278001 21964515 21967349 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020278001 21964515 21967349 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037513001 12438363 12486283 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01037513001 12438363 12486283 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01037513001 12438363 12486283 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01037513001 12438363 12486283 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008831001 2543733 2568290 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01008831001 2543733 2568290 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01015742001 16692712 16702257 GSVIVG01024454001 2769499 2778763 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01024454001 2769499 2778763 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01024454001 2769499 2778763 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01029102001 19725539 19781357 GO:0007205 activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway The initiation of the activity of the inactive enzyme protein kinase C as the result of a series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol 3-phosphate. IEA GO:0004143 diacylglycerol kinase activity GSVIVG01029070001 11812246 11816013 GSVIVG01038250001 24664929 24673164 GSVIVG01025113001 4327137 4334369 GSVIVG01005022001 17241850 17244335 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0008236 serine-type peptidase activity GSVIVG01031818001 4670024 4676294 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01031818001 4670024 4676294 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01015930001 15262179 15265802 GSVIVG01011645001 5627438 5633661 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01025525001 14329875 14332391 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01022252001 17855347 17857136 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01038263001 24791623 24795408 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01037358001 15076740 15198125 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028483001 8179854 8186303 GSVIVG01016249001 5929585 5930022 GSVIVG01014421001 3610668 3614137 GSVIVG01024070001 1364748 1369637 GO:0006278 RNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01024070001 1364748 1369637 GO:0006278 RNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. IEA Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time. IEA GO:0003964 RNA-directed DNA polymerase activity GSVIVG01024070001 1364748 1369637 GO:0006278 RNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. IEA Catalysis of the transfer of the amide nitrogen of glutamine to a variety of substrates. GATases catalyze two separate reactions at two active sites, which are located either on a single polypeptide chain or on different subunits. In the glutaminase reaction, glutamine is hydrolyzed to glutamate and ammonia, which is added to an acceptor substrate in the synthase reaction. IEA GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor GSVIVG01038100001 23496192 23498289 GSVIVG01020546001 4613523 4622844 GO:0006278 RNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01020546001 4613523 4622844 GO:0006278 RNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. IEA Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time. IEA GO:0003964 RNA-directed DNA polymerase activity GSVIVG01001840001 26224541 26227704 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024073001 1349912 1356647 GSVIVG01038209001 24370871 24372633 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01029842001 327876 333847 GO:0006007 glucose catabolic process The chemical reactions and pathways resulting in the breakdown of glucose, the aldohexose gluco-hexose. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029842001 327876 333847 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029842001 327876 333847 GO:0006007 glucose catabolic process The chemical reactions and pathways resulting in the breakdown of glucose, the aldohexose gluco-hexose. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D-glycerate. IEA GO:0004619 phosphoglycerate mutase activity GSVIVG01029842001 327876 333847 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D-glycerate. IEA GO:0004619 phosphoglycerate mutase activity GSVIVG01029842001 327876 333847 GO:0006007 glucose catabolic process The chemical reactions and pathways resulting in the breakdown of glucose, the aldohexose gluco-hexose. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with manganese (Mn) ions. IEA GO:0030145 manganese ion binding GSVIVG01029842001 327876 333847 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with manganese (Mn) ions. IEA GO:0030145 manganese ion binding GSVIVG01029842001 327876 333847 GO:0006007 glucose catabolic process The chemical reactions and pathways resulting in the breakdown of glucose, the aldohexose gluco-hexose. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01029842001 327876 333847 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01020313001 21501166 21502842 GSVIVG01009069001 4683422 4686537 GSVIVG01015297001 2469989 2477832 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01015297001 2469989 2477832 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01015297001 2469989 2477832 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: ATP + D-hexose = ADP + D-hexose 6-phosphate. IEA GO:0004396 hexokinase activity GSVIVG01015297001 2469989 2477832 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the reaction: ATP + D-hexose = ADP + D-hexose 6-phosphate. IEA GO:0004396 hexokinase activity GSVIVG01015297001 2469989 2477832 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015297001 2469989 2477832 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015297001 2469989 2477832 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01015297001 2469989 2477832 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01015297001 2469989 2477832 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01015297001 2469989 2477832 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01015297001 2469989 2477832 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01015297001 2469989 2477832 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01015550001 4812614 4814081 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024195001 440845 445043 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01024195001 440845 445043 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01024195001 440845 445043 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01024195001 440845 445043 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01006250001 24073513 24078749 GSVIVG01021788001 7419611 7427042 GO:0009306 protein secretion The controlled release of proteins from a cell or group of cells. IEA GO:0005886 plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01021788001 7419611 7427042 GO:0009306 protein secretion The controlled release of proteins from a cell or group of cells. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01021788001 7419611 7427042 GO:0009306 protein secretion The controlled release of proteins from a cell or group of cells. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01021788001 7419611 7427042 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005886 plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01021788001 7419611 7427042 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01021788001 7419611 7427042 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01007194001 62912 64261 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01000255001 20592274 20594411 GSVIVG01013663001 2135300 2136089 GSVIVG01008988001 4072111 4072857 GSVIVG01011157001 7427062 7475230 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019573001 1690753 1698172 GSVIVG01005847001 22227162 22231145 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01005847001 22227162 22231145 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01005847001 22227162 22231145 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01005847001 22227162 22231145 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01005847001 22227162 22231145 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01005847001 22227162 22231145 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01005847001 22227162 22231145 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01005847001 22227162 22231145 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01017901001 4491107 4495464 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01024881001 6257282 6257928 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024881001 6257282 6257928 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024881001 6257282 6257928 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024881001 6257282 6257928 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024881001 6257282 6257928 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024881001 6257282 6257928 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024881001 6257282 6257928 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01024881001 6257282 6257928 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01024881001 6257282 6257928 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01024881001 6257282 6257928 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024881001 6257282 6257928 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024881001 6257282 6257928 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01014592001 5411343 5414641 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01022112001 16671335 16682195 GO:0019363 pyridine nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base. IEA Catalysis of the reaction: nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate. IEA GO:0004516 nicotinate phosphoribosyltransferase activity GSVIVG01013126001 7942404 7943735 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01018973001 18202174 18202332 GSVIVG01028884001 17824939 17825396 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01028884001 17824939 17825396 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01028884001 17824939 17825396 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01028884001 17824939 17825396 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01022350001 18843587 18860456 GSVIVG01036800001 22386461 22391612 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028770001 19015882 19017151 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028770001 19015882 19017151 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01004861001 179108 182490 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01004861001 179108 182490 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01004861001 179108 182490 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01004861001 179108 182490 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016835001 1779544 1784569 GSVIVG01019150001 16085319 16105882 GSVIVG01027813001 8075613 8090454 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01027813001 8075613 8090454 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01023482001 11169649 11170833 GSVIVG01033227001 10021512 10031050 GSVIVG01002283001 33985763 33994363 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01034887001 15967402 15986153 GSVIVG01019341001 801097 801252 GSVIVG01033315001 21575044 21576438 GSVIVG01025492001 355720 359838 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025492001 355720 359838 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01025492001 355720 359838 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01025492001 355720 359838 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01025492001 355720 359838 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019475001 933100 947137 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01019475001 933100 947137 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01019475001 933100 947137 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019475001 933100 947137 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019475001 933100 947137 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01019475001 933100 947137 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01019475001 933100 947137 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01019475001 933100 947137 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01019475001 933100 947137 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01019475001 933100 947137 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01009942001 12678960 12679433 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01009942001 12678960 12679433 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01011674001 5326113 5326468 GSVIVG01008421001 2264175 2265053 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01013758001 7893948 7896384 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013758001 7893948 7896384 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01013758001 7893948 7896384 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage. IEA GO:0016209 antioxidant activity GSVIVG01013758001 7893948 7896384 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024817001 6660249 6663341 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01024817001 6660249 6663341 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01037956001 11527946 11538707 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01015513001 4350408 4357913 Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01030089001 9745480 9747379 GSVIVG01006163001 42297960 42299925 GSVIVG01023365001 19256260 19258057 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01023365001 19256260 19258057 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01023365001 19256260 19258057 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01023365001 19256260 19258057 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023365001 19256260 19258057 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017522001 9871408 9877589 GO:0006525 arginine metabolic process The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01017522001 9871408 9877589 GO:0006525 arginine metabolic process The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid. IEA Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. IEA GO:0008483 transaminase activity GSVIVG01017522001 9871408 9877589 GO:0006525 arginine metabolic process The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01013472001 130986 159404 GSVIVG01020911001 17358932 17387128 GO:0032313 regulation of Rab GTPase activity Any process that modulates the activity of a GTPase of the Rab family. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Increases the rate of GTP hydrolysis by a GTPase of the Rab family. IEA GO:0005097 Rab GTPase activator activity GSVIVG01025116001 4296027 4318377 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and carries out proton transport across a membrane. The proton-transporting domain (F0, V0, or A0) includes integral and peripheral membrane proteins. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01017056001 3824683 3834327 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000985001 11146743 11148152 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004185 serine-type carboxypeptidase activity GSVIVG01010605001 16096085 16099561 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01010605001 16096085 16099561 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01010605001 16096085 16099561 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01010605001 16096085 16099561 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01022924001 17961018 17984152 GO:0046488 phosphatidylinositol metabolic process The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. IEA Catalysis of the phosphorylation of phosphatidylinositol phosphate to produce phosphatidylinositol bisphosphate. IEA GO:0016307 phosphatidylinositol phosphate kinase activity GSVIVG01034937001 247631 248316 GSVIVG01030497001 6203927 6213938 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01030497001 6203927 6213938 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01012462001 1194652 1200079 GSVIVG01012222001 453463 457950 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01012222001 453463 457950 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01019239001 2903815 2930485 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01019239001 2903815 2930485 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01019239001 2903815 2930485 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01019239001 2903815 2930485 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019239001 2903815 2930485 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01019239001 2903815 2930485 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01010360001 19784551 19799430 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA Catalysis of the reaction: urea + H2O = CO2 + 2 NH3. IEA GO:0009039 urease activity GSVIVG01010360001 19784551 19799430 GO:0019627 urea metabolic process The chemical reactions and pathways involving urea, the water soluble compound O=C-(NH2)2, produced in the liver by the ornithine cycle. It is the main nitrogen-containing excretion product in ureotelic animals. IEA Catalysis of the reaction: urea + H2O = CO2 + 2 NH3. IEA GO:0009039 urease activity GSVIVG01010360001 19784551 19799430 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA Interacting selectively and non-covalently with nickel (Ni) ions. IEA GO:0016151 nickel ion binding GSVIVG01010360001 19784551 19799430 GO:0019627 urea metabolic process The chemical reactions and pathways involving urea, the water soluble compound O=C-(NH2)2, produced in the liver by the ornithine cycle. It is the main nitrogen-containing excretion product in ureotelic animals. IEA Interacting selectively and non-covalently with nickel (Ni) ions. IEA GO:0016151 nickel ion binding GSVIVG01010360001 19784551 19799430 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01010360001 19784551 19799430 GO:0019627 urea metabolic process The chemical reactions and pathways involving urea, the water soluble compound O=C-(NH2)2, produced in the liver by the ornithine cycle. It is the main nitrogen-containing excretion product in ureotelic animals. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01010360001 19784551 19799430 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. IEA GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GSVIVG01010360001 19784551 19799430 GO:0019627 urea metabolic process The chemical reactions and pathways involving urea, the water soluble compound O=C-(NH2)2, produced in the liver by the ornithine cycle. It is the main nitrogen-containing excretion product in ureotelic animals. IEA Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. IEA GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GSVIVG01021606001 7915109 7917268 GSVIVG01011976001 2476586 2477742 GSVIVG01036899001 17983716 17984127 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01036899001 17983716 17984127 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01036899001 17983716 17984127 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015934 large ribosomal subunit The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01017739001 3050543 3051394 GSVIVG01031755001 4070578 4072718 GSVIVG01008827001 2513715 2517765 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01015459001 3855101 3862713 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: bile acid(out) + Na+(out) = bile acid(in) + Na+(in). IEA GO:0008508 bile acid:sodium symporter activity GSVIVG01015459001 3855101 3862713 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: bile acid(out) + Na+(out) = bile acid(in) + Na+(in). IEA GO:0008508 bile acid:sodium symporter activity GSVIVG01015459001 3855101 3862713 GO:0015711 organic anion transport The directed movement of organic anions into, out of, within or between cells by means of some external agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: bile acid(out) + Na+(out) = bile acid(in) + Na+(in). IEA GO:0008508 bile acid:sodium symporter activity GSVIVG01015459001 3855101 3862713 GO:0015711 organic anion transport The directed movement of organic anions into, out of, within or between cells by means of some external agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: bile acid(out) + Na+(out) = bile acid(in) + Na+(in). IEA GO:0008508 bile acid:sodium symporter activity GSVIVG01010845001 23317514 23326057 Catalysis of the reaction: (S)-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate. IEA GO:0004416 hydroxyacylglutathione hydrolase activity GSVIVG01010845001 23317514 23326057 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01010845001 23317514 23326057 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01030990001 20413600 20415403 GO:0006541 glutamine metabolic process The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01008232001 4378226 4378408 GSVIVG01003287001 14157939 14158523 GSVIVG01033752001 18101750 18121870 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01033752001 18101750 18121870 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01033752001 18101750 18121870 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01033752001 18101750 18121870 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01005230001 19564238 19570493 GSVIVG01001313001 5241335 5245744 GSVIVG01038510001 10713059 10717173 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01038510001 10713059 10717173 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01025378001 1236105 1241939 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01025378001 1236105 1241939 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01025378001 1236105 1241939 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01025378001 1236105 1241939 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009958001 12823491 12836197 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01019396001 303719 306660 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025695001 12902415 12906962 GSVIVG01024666001 7936911 7943092 GSVIVG01038509001 10700918 10703632 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01038509001 10700918 10703632 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01038509001 10700918 10703632 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01038509001 10700918 10703632 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01008084001 5956396 5958811 GSVIVG01004648001 39405015 39407278 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01004648001 39405015 39407278 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01004648001 39405015 39407278 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01004648001 39405015 39407278 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01004648001 39405015 39407278 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01004648001 39405015 39407278 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01038189001 24207274 24208286 GSVIVG01010591001 16239562 16240545 GSVIVG01006113001 41717440 41717526 GSVIVG01020054001 11028169 11033705 GSVIVG01029550001 21690855 21691632 GSVIVG01010623001 15905765 15907815 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01010623001 15905765 15907815 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01016510001 3269121 3294047 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01016510001 3269121 3294047 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016510001 3269121 3294047 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01024187001 503106 504318 Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01024187001 503106 504318 Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01015116001 1155354 1156843 GSVIVG01036281001 7570475 7577106 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01036281001 7570475 7577106 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01036281001 7570475 7577106 GO:0042742 defense response to bacterium Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01036281001 7570475 7577106 GO:0050832 defense response to fungus Reactions triggered in response to the presence of a fungus that act to protect the cell or organism. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01032640001 1933794 1938539 GO:0008654 phospholipid biosynthetic process The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: CDP-diacylglycerol + glycerol 3-phosphate = CMP + 3-(3-phosphatidyl)-glycerol 1-phosphate. IEA GO:0008444 CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity GSVIVG01032640001 1933794 1938539 GO:0008654 phospholipid biosynthetic process The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: CDP-diacylglycerol + glycerol 3-phosphate = CMP + 3-(3-phosphatidyl)-glycerol 1-phosphate. IEA GO:0008444 CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity GSVIVG01032640001 1933794 1938539 GO:0008654 phospholipid biosynthetic process The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor). IEA GO:0016780 phosphotransferase activity, for other substituted phosphate groups GSVIVG01032640001 1933794 1938539 GO:0008654 phospholipid biosynthetic process The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor). IEA GO:0016780 phosphotransferase activity, for other substituted phosphate groups GSVIVG01007423001 31749776 31750390 GSVIVG01023068001 15921421 15932390 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01023068001 15921421 15932390 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016438001 3911338 3914506 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01016438001 3911338 3914506 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01016438001 3911338 3914506 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01016438001 3911338 3914506 GO:0042254 ribosome biogenesis The process of the formation of the constituents of the ribosome subunits, their assembly, and their transport to the sites of protein synthesis. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01016438001 3911338 3914506 GO:0042254 ribosome biogenesis The process of the formation of the constituents of the ribosome subunits, their assembly, and their transport to the sites of protein synthesis. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01016438001 3911338 3914506 GO:0042254 ribosome biogenesis The process of the formation of the constituents of the ribosome subunits, their assembly, and their transport to the sites of protein synthesis. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01019683001 2433517 2434662 GSVIVG01019997001 11821156 11827166 GSVIVG01034202001 14455116 14458351 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01034202001 14455116 14458351 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01034202001 14455116 14458351 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01037709001 7136387 7138873 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01037709001 7136387 7138873 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01037343001 15422283 15433949 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01037343001 15422283 15433949 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = acetyl-CoA + acetoacetate. IEA GO:0004419 hydroxymethylglutaryl-CoA lyase activity GSVIVG01019351001 618649 624109 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01019351001 618649 624109 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01019351001 618649 624109 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01019351001 618649 624109 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01019351001 618649 624109 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019351001 618649 624109 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032552001 28307791 28309199 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01032552001 28307791 28309199 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032552001 28307791 28309199 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01027407001 16989617 16991196 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01027407001 16989617 16991196 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01027407001 16989617 16991196 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01027407001 16989617 16991196 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01027407001 16989617 16991196 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01027407001 16989617 16991196 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01027407001 16989617 16991196 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01027407001 16989617 16991196 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01027355001 15946708 15949564 GSVIVG01016144001 19674807 19676813 GO:0006887 exocytosis A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell. This is the process whereby most molecules are secreted from eukaryotic cells. IEA GO:0000145 exocyst A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals. IEA GSVIVG01003631001 541711 542354 GSVIVG01023097001 22673039 22690315 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01010362001 19816505 19833346 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01010362001 19816505 19833346 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01010362001 19816505 19833346 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01010362001 19816505 19833346 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010362001 19816505 19833346 Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01010362001 19816505 19833346 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01034596001 14738647 14747976 GSVIVG01013210001 6687939 6688022 GSVIVG01008051001 6230028 6253619 GSVIVG01003475001 10594891 10600286 GSVIVG01020479001 18754506 18762882 GSVIVG01021521001 6548128 6554955 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01022995001 17166290 17173927 GSVIVG01002195001 33260972 33262224 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01002195001 33260972 33262224 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01022057001 3597479 3598170 GSVIVG01000437001 8001373 8007640 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01000437001 8001373 8007640 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01000437001 8001373 8007640 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01000437001 8001373 8007640 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01000437001 8001373 8007640 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01000437001 8001373 8007640 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01000437001 8001373 8007640 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000437001 8001373 8007640 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000437001 8001373 8007640 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01000437001 8001373 8007640 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01000865001 3189921 3192397 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01000865001 3189921 3192397 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01013794001 7520998 7523462 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01026490001 22767813 22772249 GSVIVG01009812001 11486801 11488805 GSVIVG01007967001 7094555 7095620 GSVIVG01020456001 19137067 19142116 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01020456001 19137067 19142116 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01020456001 19137067 19142116 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01020456001 19137067 19142116 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035661001 3098067 3101648 GSVIVG01001973001 5927650 5928430 GSVIVG01027809001 8009901 8031782 GSVIVG01004598001 39168723 39169887 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01004598001 39168723 39169887 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01004598001 39168723 39169887 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01004598001 39168723 39169887 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027637001 14794345 14798174 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01027637001 14794345 14798174 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01027637001 14794345 14798174 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01014163001 979171 997624 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01014163001 979171 997624 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01014163001 979171 997624 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01014163001 979171 997624 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01014163001 979171 997624 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and primer. IEA GO:0003887 DNA-directed DNA polymerase activity GSVIVG01014163001 979171 997624 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and primer. IEA GO:0003887 DNA-directed DNA polymerase activity GSVIVG01014163001 979171 997624 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end. IEA GO:0008408 3'-5' exonuclease activity GSVIVG01014163001 979171 997624 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end. IEA GO:0008408 3'-5' exonuclease activity GSVIVG01009743001 10907156 10924023 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009743001 10907156 10924023 GO:0009813 flavonoid biosynthetic process The chemical reactions and pathways resulting in the formation of flavonoids, a group of phenolic derivatives containing a flavan skeleton. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009743001 10907156 10924023 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009743001 10907156 10924023 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009743001 10907156 10924023 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01009743001 10907156 10924023 GO:0009813 flavonoid biosynthetic process The chemical reactions and pathways resulting in the formation of flavonoids, a group of phenolic derivatives containing a flavan skeleton. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01009743001 10907156 10924023 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01009743001 10907156 10924023 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01009743001 10907156 10924023 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01009743001 10907156 10924023 GO:0009813 flavonoid biosynthetic process The chemical reactions and pathways resulting in the formation of flavonoids, a group of phenolic derivatives containing a flavan skeleton. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01009743001 10907156 10924023 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01009743001 10907156 10924023 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01009743001 10907156 10924023 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: cis-3,4-leucopelargonidin + NADP+ = (+)-dihydrokaempferol + NADPH + H+. IEA GO:0045552 dihydrokaempferol 4-reductase activity GSVIVG01009743001 10907156 10924023 GO:0009813 flavonoid biosynthetic process The chemical reactions and pathways resulting in the formation of flavonoids, a group of phenolic derivatives containing a flavan skeleton. IEA Catalysis of the reaction: cis-3,4-leucopelargonidin + NADP+ = (+)-dihydrokaempferol + NADPH + H+. IEA GO:0045552 dihydrokaempferol 4-reductase activity GSVIVG01009743001 10907156 10924023 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of the reaction: cis-3,4-leucopelargonidin + NADP+ = (+)-dihydrokaempferol + NADPH + H+. IEA GO:0045552 dihydrokaempferol 4-reductase activity GSVIVG01009743001 10907156 10924023 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: cis-3,4-leucopelargonidin + NADP+ = (+)-dihydrokaempferol + NADPH + H+. IEA GO:0045552 dihydrokaempferol 4-reductase activity GSVIVG01009743001 10907156 10924023 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01009743001 10907156 10924023 GO:0009813 flavonoid biosynthetic process The chemical reactions and pathways resulting in the formation of flavonoids, a group of phenolic derivatives containing a flavan skeleton. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01009743001 10907156 10924023 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01009743001 10907156 10924023 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01038521001 10960906 10961374 GSVIVG01032687001 1541967 1543728 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01032687001 1541967 1543728 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01032687001 1541967 1543728 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01032687001 1541967 1543728 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01026875001 19708415 19708708 GSVIVG01030738001 14835381 14863472 GSVIVG01016505001 3328977 3330424 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033964001 16245954 16251984 GSVIVG01015565001 4977037 4984520 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01015565001 4977037 4984520 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01034567001 19328724 19350461 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01034567001 19328724 19350461 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01034567001 19328724 19350461 GO:0009060 aerobic respiration The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01034567001 19328724 19350461 GO:0009060 aerobic respiration The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01034567001 19328724 19350461 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01034567001 19328724 19350461 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01034567001 19328724 19350461 GO:0009060 aerobic respiration The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01034567001 19328724 19350461 GO:0009060 aerobic respiration The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01034567001 19328724 19350461 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01034567001 19328724 19350461 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01034567001 19328724 19350461 GO:0009060 aerobic respiration The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01034567001 19328724 19350461 GO:0009060 aerobic respiration The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01034567001 19328724 19350461 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01034567001 19328724 19350461 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01034567001 19328724 19350461 GO:0009060 aerobic respiration The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01034567001 19328724 19350461 GO:0009060 aerobic respiration The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01034567001 19328724 19350461 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01034567001 19328724 19350461 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01034567001 19328724 19350461 GO:0009060 aerobic respiration The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01034567001 19328724 19350461 GO:0009060 aerobic respiration The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01000044001 3030685 3053989 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01000044001 3030685 3053989 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01000044001 3030685 3053989 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01000044001 3030685 3053989 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01000044001 3030685 3053989 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01000044001 3030685 3053989 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01012097001 1513379 1514013 GSVIVG01011711001 4878611 4879983 GSVIVG01007919001 7527950 7530932 GSVIVG01016664001 218550 226887 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01016664001 218550 226887 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01022699001 15249992 15252087 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. IEA GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GSVIVG01025023001 5192257 5193793 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025023001 5192257 5193793 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01024573001 8694412 8696050 GSVIVG01015156001 1424761 1427979 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015156001 1424761 1427979 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. IEA GO:0004722 protein serine/threonine phosphatase activity GSVIVG01012782001 23339416 23341105 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01029961001 2368988 2371047 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other. IEA GO:0005337 nucleoside transmembrane transporter activity GSVIVG01029961001 2368988 2371047 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other. IEA GO:0005337 nucleoside transmembrane transporter activity GSVIVG01029961001 2368988 2371047 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other. IEA GO:0005337 nucleoside transmembrane transporter activity GSVIVG01029961001 2368988 2371047 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other. IEA GO:0005337 nucleoside transmembrane transporter activity GSVIVG01024794001 6896486 6899031 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01036556001 23414431 23425220 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01036556001 23414431 23425220 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N2-methylguanine. IEA GO:0004809 tRNA (guanine-N2-)-methyltransferase activity GSVIVG01003666001 11935209 11936867 GSVIVG01036878001 18337138 18337386 GSVIVG01036488001 22614679 22614729 GSVIVG01036439001 21924507 21931478 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01036439001 21924507 21931478 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01036439001 21924507 21931478 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01036439001 21924507 21931478 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01036439001 21924507 21931478 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01036439001 21924507 21931478 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01036439001 21924507 21931478 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01036439001 21924507 21931478 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01032864001 122665 126385 Catalysis of the reaction: (S)-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate. IEA GO:0004416 hydroxyacylglutathione hydrolase activity GSVIVG01032864001 122665 126385 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01032864001 122665 126385 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01005055001 17741398 17746352 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01005055001 17741398 17746352 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024096001 1111137 1113257 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024096001 1111137 1113257 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013220001 6634762 6636649 GSVIVG01033476001 20386692 20388380 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Functions to increase the rate of ATP hydrolysis. IEA GO:0001671 ATPase activator activity GSVIVG01033476001 20386692 20388380 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport. IEA GO:0051087 chaperone binding GSVIVG01008083001 5958856 5961585 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GSVIVG01017060001 3851524 3860298 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01017060001 3851524 3860298 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01017060001 3851524 3860298 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01017060001 3851524 3860298 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01017060001 3851524 3860298 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030339001 8572498 8576525 GSVIVG01032290001 14621055 14625298 GSVIVG01029413001 16880776 16880844 GSVIVG01001422001 18980574 18985327 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001422001 18980574 18985327 Catalysis of the elimination of H2S or substituted H2S. IEA GO:0016846 carbon-sulfur lyase activity GSVIVG01001422001 18980574 18985327 Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01015560001 4929236 4930629 Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01015560001 4929236 4930629 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01034918001 123743 124074 GSVIVG01012388001 317019 320145 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012388001 317019 320145 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012388001 317019 320145 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01012388001 317019 320145 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01012388001 317019 320145 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01012388001 317019 320145 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01038543001 22031591 22038414 GSVIVG01004910001 4745516 4746562 GSVIVG01027643001 14748550 14759139 The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01012713001 898873 915904 Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal. IEA GO:0004462 lactoylglutathione lyase activity GSVIVG01012713001 898873 915904 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01014308001 2532218 2534678 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01014308001 2532218 2534678 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01014308001 2532218 2534678 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01014308001 2532218 2534678 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01011089001 1683603 1688253 GSVIVG01036292001 3439292 3443634 GSVIVG01006589001 26897077 26899028 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01006589001 26897077 26899028 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01010946001 2749924 2751301 GSVIVG01010615001 15992673 15995667 GSVIVG01016048001 17906812 17907895 GSVIVG01007191001 52928 55919 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01007191001 52928 55919 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01007191001 52928 55919 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA GO:0008061 chitin binding GSVIVG01007191001 52928 55919 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA GO:0008061 chitin binding GSVIVG01002444001 776399 792076 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. IEA GO:0008080 N-acetyltransferase activity GSVIVG01036988001 9215900 9223451 GSVIVG01019423001 557003 570448 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008404001 2414103 2416028 GSVIVG01019397001 308882 315609 GSVIVG01022158001 17118430 17121629 GO:0006021 inositol biosynthetic process The chemical reactions and pathways resulting in the formation of inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01022158001 17118430 17121629 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01022158001 17118430 17121629 GO:0008654 phospholipid biosynthetic process The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01022158001 17118430 17121629 GO:0006021 inositol biosynthetic process The chemical reactions and pathways resulting in the formation of inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms. IEA Catalysis of the reaction: D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate; requires NAD, which dehydrogenates the CHOH group to CO at C-5 of the glucose 6-phosphate, making C-6 into an active methylene, able to condense with the aldehyde at C-1. Finally, the enzyme-bound NADH reconverts C-5 into the CHOH form. IEA GO:0004512 inositol-3-phosphate synthase activity GSVIVG01022158001 17118430 17121629 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate; requires NAD, which dehydrogenates the CHOH group to CO at C-5 of the glucose 6-phosphate, making C-6 into an active methylene, able to condense with the aldehyde at C-1. Finally, the enzyme-bound NADH reconverts C-5 into the CHOH form. IEA GO:0004512 inositol-3-phosphate synthase activity GSVIVG01022158001 17118430 17121629 GO:0008654 phospholipid biosynthetic process The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester. IEA Catalysis of the reaction: D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate; requires NAD, which dehydrogenates the CHOH group to CO at C-5 of the glucose 6-phosphate, making C-6 into an active methylene, able to condense with the aldehyde at C-1. Finally, the enzyme-bound NADH reconverts C-5 into the CHOH form. IEA GO:0004512 inositol-3-phosphate synthase activity GSVIVG01022158001 17118430 17121629 GO:0006021 inositol biosynthetic process The chemical reactions and pathways resulting in the formation of inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01022158001 17118430 17121629 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01022158001 17118430 17121629 GO:0008654 phospholipid biosynthetic process The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01009024001 4363667 4369067 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01009024001 4363667 4369067 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01009024001 4363667 4369067 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01009024001 4363667 4369067 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01009024001 4363667 4369067 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01009024001 4363667 4369067 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01009024001 4363667 4369067 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01009024001 4363667 4369067 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01000175001 15881221 15881409 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01000175001 15881221 15881409 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01000175001 15881221 15881409 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01000175001 15881221 15881409 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01000175001 15881221 15881409 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01000175001 15881221 15881409 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01000175001 15881221 15881409 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01000175001 15881221 15881409 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01000175001 15881221 15881409 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01027157001 17371751 17374868 GSVIVG01028856001 18054147 18057038 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028856001 18054147 18057038 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028856001 18054147 18057038 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01028856001 18054147 18057038 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01008427001 2193669 2196996 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01003452001 10276932 10282101 GSVIVG01012955001 11847579 11848204 GSVIVG01000146001 15634254 15637958 GO:0009416 response to light stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01000146001 15634254 15637958 GO:0009416 response to light stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018377001 10070523 10119523 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018377001 10070523 10119523 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018377001 10070523 10119523 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018377001 10070523 10119523 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate. IEA GO:0004470 malic enzyme activity GSVIVG01018377001 10070523 10119523 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate. IEA GO:0004470 malic enzyme activity GSVIVG01018377001 10070523 10119523 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate. IEA GO:0004470 malic enzyme activity GSVIVG01018377001 10070523 10119523 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01018377001 10070523 10119523 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01018377001 10070523 10119523 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01018377001 10070523 10119523 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01018377001 10070523 10119523 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01018377001 10070523 10119523 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01018377001 10070523 10119523 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01018377001 10070523 10119523 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01018377001 10070523 10119523 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01018377001 10070523 10119523 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01018377001 10070523 10119523 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01018377001 10070523 10119523 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01018377001 10070523 10119523 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01018377001 10070523 10119523 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01018377001 10070523 10119523 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01006038001 23380298 23389490 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000802001 279315 292144 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01000802001 279315 292144 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01000802001 279315 292144 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01000802001 279315 292144 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01000802001 279315 292144 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01000802001 279315 292144 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01000802001 279315 292144 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01000802001 279315 292144 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01000802001 279315 292144 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01031991001 23714917 23720855 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031991001 23714917 23720855 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031991001 23714917 23720855 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031991001 23714917 23720855 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026312001 13438818 13455736 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with melanocortin to initiate a change in cell activity. IEA GO:0004977 melanocortin receptor activity GSVIVG01023878001 2759562 2764805 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01023878001 2759562 2764805 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01023878001 2759562 2764805 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01023878001 2759562 2764805 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021829001 6790508 6792479 GSVIVG01022986001 17296579 17296689 GSVIVG01002602001 35359691 35360984 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008865001 2904023 2905267 GSVIVG01010048001 13811801 13817045 GSVIVG01012935001 13829243 13829482 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01012935001 13829243 13829482 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01012935001 13829243 13829482 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01012935001 13829243 13829482 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01018420001 9309870 9314194 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01018420001 9309870 9314194 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01018420001 9309870 9314194 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01018420001 9309870 9314194 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01036428001 5037306 5041379 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01036428001 5037306 5041379 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01036428001 5037306 5041379 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01036428001 5037306 5041379 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01036428001 5037306 5041379 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051537 2 iron, 2 sulfur cluster binding GSVIVG01032600001 28755821 28756800 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GSVIVG01037371001 14849252 14850194 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01037371001 14849252 14850194 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01037371001 14849252 14850194 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01037371001 14849252 14850194 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036035001 7650583 7651498 GSVIVG01025786001 11881167 11892276 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01024902001 6156545 6157123 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01024902001 6156545 6157123 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01022610001 13345788 13348282 GSVIVG01015704001 16023963 16025246 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01027911001 9290311 9307076 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01009904001 12292299 12294516 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01014742001 9116147 9126416 GSVIVG01021301001 3697568 3713462 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01021301001 3697568 3713462 GO:0009966 regulation of signal transduction Any process that modulates the frequency, rate or extent of signal transduction. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01021301001 3697568 3713462 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01021301001 3697568 3713462 GO:0009966 regulation of signal transduction Any process that modulates the frequency, rate or extent of signal transduction. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01021301001 3697568 3713462 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01021301001 3697568 3713462 GO:0009966 regulation of signal transduction Any process that modulates the frequency, rate or extent of signal transduction. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01021301001 3697568 3713462 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021301001 3697568 3713462 GO:0009966 regulation of signal transduction Any process that modulates the frequency, rate or extent of signal transduction. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024643001 8102108 8129234 GSVIVG01020680001 3145880 3152445 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01026757001 6285041 6288919 GSVIVG01014565001 5214960 5225074 Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01014565001 5214960 5225074 Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01016773001 1224354 1224918 GSVIVG01036150001 20050566 20052967 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0030173 integral to Golgi membrane Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the Golgi complex membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Catalysis of the formation of sialylglycoconjugates via transfer of the sialic acid group from CMP to one of several glycoconjugate acceptors. IEA GO:0008373 sialyltransferase activity GSVIVG01029662001 12663578 12664969 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with a lipid. IEA GO:0008289 lipid binding GSVIVG01029662001 12663578 12664969 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and carries out proton transport across a membrane. The proton-transporting domain (F0, V0, or A0) includes integral and peripheral membrane proteins. IEA Interacting selectively and non-covalently with a lipid. IEA GO:0008289 lipid binding GSVIVG01029662001 12663578 12664969 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o) All non-F1 subunits of a hydrogen-transporting ATP synthase, including integral and peripheral membrane proteins. IEA Interacting selectively and non-covalently with a lipid. IEA GO:0008289 lipid binding GSVIVG01029662001 12663578 12664969 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01029662001 12663578 12664969 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and carries out proton transport across a membrane. The proton-transporting domain (F0, V0, or A0) includes integral and peripheral membrane proteins. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01029662001 12663578 12664969 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o) All non-F1 subunits of a hydrogen-transporting ATP synthase, including integral and peripheral membrane proteins. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01029662001 12663578 12664969 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01029662001 12663578 12664969 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and carries out proton transport across a membrane. The proton-transporting domain (F0, V0, or A0) includes integral and peripheral membrane proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01029662001 12663578 12664969 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o) All non-F1 subunits of a hydrogen-transporting ATP synthase, including integral and peripheral membrane proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01011840001 3727773 3730367 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01011840001 3727773 3730367 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01024934001 5927929 5928845 GSVIVG01034135001 14914947 14916156 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01034135001 14914947 14916156 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01020365001 20515117 20517420 GSVIVG01024090001 1222324 1226936 GSVIVG01024049001 1497503 1500305 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024049001 1497503 1500305 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01024049001 1497503 1500305 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01006502001 42407634 42408429 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01032766001 929544 935570 GO:0000228 nuclear chromosome A chromosome found in the nucleus of a eukaryotic cell. IEA GSVIVG01014321001 2609294 2611769 GSVIVG01018954001 18395062 18396178 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01018954001 18395062 18396178 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01018954001 18395062 18396178 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01018954001 18395062 18396178 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ribosomal RNA. IEA GO:0019843 rRNA binding GSVIVG01018954001 18395062 18396178 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with ribosomal RNA. IEA GO:0019843 rRNA binding GSVIVG01018954001 18395062 18396178 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA Interacting selectively and non-covalently with ribosomal RNA. IEA GO:0019843 rRNA binding GSVIVG01032680001 1581110 1584012 GSVIVG01031968001 5798734 5801287 GSVIVG01031191001 1327699 1329918 GSVIVG01037261001 16772781 16786075 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01014695001 8721937 8728041 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01026154001 13080413 13080550 GSVIVG01011558001 6498776 6503087 GSVIVG01020056001 11008741 11013679 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01020056001 11008741 11013679 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01008417001 2298243 2304096 GSVIVG01000839001 2751480 2757982 GSVIVG01007852001 8367185 8369444 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion. IEA GO:0004806 triglyceride lipase activity GSVIVG01002756001 36396853 36400493 GSVIVG01027719001 7082504 7083190 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01034664001 7341746 7355383 GSVIVG01003493001 10730939 10733455 GSVIVG01014689001 8666963 8668364 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01014689001 8666963 8668364 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01014689001 8666963 8668364 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01014689001 8666963 8668364 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01026315001 13532933 13535281 GSVIVG01037720001 7236473 7240677 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Stimulates the hydrolysis and exchange of adenyl nucleotides by other proteins. IEA GO:0000774 adenyl-nucleotide exchange factor activity GSVIVG01037720001 7236473 7240677 GO:0030150 protein import into mitochondrial matrix The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Stimulates the hydrolysis and exchange of adenyl nucleotides by other proteins. IEA GO:0000774 adenyl-nucleotide exchange factor activity GSVIVG01037720001 7236473 7240677 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01037720001 7236473 7240677 GO:0030150 protein import into mitochondrial matrix The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01037720001 7236473 7240677 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with an identical protein to form a homodimer. IEA GO:0042803 protein homodimerization activity GSVIVG01037720001 7236473 7240677 GO:0030150 protein import into mitochondrial matrix The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with an identical protein to form a homodimer. IEA GO:0042803 protein homodimerization activity GSVIVG01037720001 7236473 7240677 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport. IEA GO:0051087 chaperone binding GSVIVG01037720001 7236473 7240677 GO:0030150 protein import into mitochondrial matrix The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport. IEA GO:0051087 chaperone binding GSVIVG01038732001 37860 55349 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01038732001 37860 55349 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01034877001 15773213 15774934 GSVIVG01013515001 2070611 2071639 Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01013515001 2070611 2071639 Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01036647001 19765075 19766298 GSVIVG01035570001 2388545 2390093 GSVIVG01031764001 4192399 4198551 GSVIVG01026323001 13962498 13964668 GSVIVG01009815001 11506514 11512366 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01009815001 11506514 11512366 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01009815001 11506514 11512366 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01009815001 11506514 11512366 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01009815001 11506514 11512366 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01009815001 11506514 11512366 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01009815001 11506514 11512366 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01009815001 11506514 11512366 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01009815001 11506514 11512366 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01013671001 2336753 2342408 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01018536001 13708354 13711799 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01018536001 13708354 13711799 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01018536001 13708354 13711799 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01018536001 13708354 13711799 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018536001 13708354 13711799 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000641001 20299051 20312035 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000641001 20299051 20312035 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007478001 32169699 32170626 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01007478001 32169699 32170626 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01007478001 32169699 32170626 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01007478001 32169699 32170626 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026587001 21358596 21362779 GSVIVG01006667001 27343538 27343800 GSVIVG01031693001 20265977 20266435 GSVIVG01009630001 10047421 10049442 GSVIVG01002784001 36405169 36413635 GSVIVG01019803001 3458409 3464102 GSVIVG01015905001 19131622 19132932 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0016459 myosin complex A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01015905001 19131622 19132932 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0016459 myosin complex A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. IEA Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate. IEA GO:0003774 motor activity GSVIVG01015905001 19131622 19132932 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0016459 myosin complex A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015905001 19131622 19132932 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0016459 myosin complex A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01015905001 19131622 19132932 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0016459 myosin complex A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01020560001 4360288 4361583 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020560001 4360288 4361583 GO:0006433 prolyl-tRNA aminoacylation The process of coupling proline to prolyl-tRNA, catalyzed by prolyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020560001 4360288 4361583 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro). IEA GO:0004827 proline-tRNA ligase activity GSVIVG01020560001 4360288 4361583 GO:0006433 prolyl-tRNA aminoacylation The process of coupling proline to prolyl-tRNA, catalyzed by prolyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro). IEA GO:0004827 proline-tRNA ligase activity GSVIVG01020560001 4360288 4361583 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020560001 4360288 4361583 GO:0006433 prolyl-tRNA aminoacylation The process of coupling proline to prolyl-tRNA, catalyzed by prolyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033035001 25234935 25237143 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01033035001 25234935 25237143 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with double-stranded RNA. IEA GO:0003725 double-stranded RNA binding GSVIVG01025096001 4544627 4548617 GSVIVG01009822001 11552102 11558455 GSVIVG01004637001 39250935 39253782 GSVIVG01021935001 5382575 5390953 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01021935001 5382575 5390953 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01021935001 5382575 5390953 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021935001 5382575 5390953 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021935001 5382575 5390953 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01021935001 5382575 5390953 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01001311001 5224810 5228573 GSVIVG01022884001 18376637 18377727 GSVIVG01013054001 9124646 9137039 GSVIVG01021928001 5496255 5496566 GSVIVG01030040001 9070142 9076754 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01030040001 9070142 9076754 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01018040001 5740523 5747815 GO:0019509 L-methionine salvage from methylthioadenosine The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01018040001 5740523 5747815 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01018040001 5740523 5747815 GO:0019509 L-methionine salvage from methylthioadenosine The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine. IEA Catalysis of the incorporation of both atoms of oxygen from one molecule of O2 into the (reduced) product(s) of the reaction. The two atoms of oxygen may be distributed between two different products. IEA GO:0051213 dioxygenase activity GSVIVG01018040001 5740523 5747815 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of both atoms of oxygen from one molecule of O2 into the (reduced) product(s) of the reaction. The two atoms of oxygen may be distributed between two different products. IEA GO:0051213 dioxygenase activity GSVIVG01030128001 10085303 10108847 GSVIVG01024370001 1706790 1713203 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01010468001 20828171 20830796 Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. IEA GO:0008171 O-methyltransferase activity GSVIVG01010710001 12224684 12232830 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01010710001 12224684 12232830 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01000878001 3117079 3138065 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01022216001 17557937 17566166 GSVIVG01038692001 20939769 20940254 GSVIVG01032725001 1243142 1248864 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032725001 1243142 1248864 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032725001 1243142 1248864 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032725001 1243142 1248864 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032725001 1243142 1248864 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032725001 1243142 1248864 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032725001 1243142 1248864 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032725001 1243142 1248864 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032725001 1243142 1248864 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032725001 1243142 1248864 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032725001 1243142 1248864 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032725001 1243142 1248864 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01036275001 7630581 7635484 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0016272 prefoldin complex A multisubunit chaperone that acts to delivers unfolded proteins to cytosolic chaperonin. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01030110001 9934678 9934779 GSVIVG01034038001 15667581 15669486 GSVIVG01038540001 11275205 11275881 GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA GSVIVG01005681001 21218042 21222211 GO:0008299 isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. IEA GSVIVG01024579001 8662127 8663803 GSVIVG01003585001 10968074 10970795 GSVIVG01009087001 4900041 4954309 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009087001 4900041 4954309 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01009087001 4900041 4954309 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01022592001 5679253 5679459 GSVIVG01031360001 29532 37629 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01031360001 29532 37629 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01031360001 29532 37629 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01031360001 29532 37629 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031360001 29532 37629 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01031360001 29532 37629 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01000189001 16000189 16002131 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01000189001 16000189 16002131 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01000189001 16000189 16002131 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01000189001 16000189 16002131 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01013279001 5701866 5714378 GO:0016068 type I hypersensitivity An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells or basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines. IEA GSVIVG01028181001 4459144 4463724 GO:0006808 regulation of nitrogen utilization Any process that modulates the frequency, rate or extent of nitrogen utilization. IEA Modulates the activity of an enzyme. IEA GO:0030234 enzyme regulator activity GSVIVG01008491001 1382388 1394519 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008491001 1382388 1394519 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008491001 1382388 1394519 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008491001 1382388 1394519 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008491001 1382388 1394519 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01008491001 1382388 1394519 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01008491001 1382388 1394519 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01008491001 1382388 1394519 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01008491001 1382388 1394519 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+. IEA GO:0004316 3-oxoacyl-[acyl-carrier-protein] reductase activity GSVIVG01008491001 1382388 1394519 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+. IEA GO:0004316 3-oxoacyl-[acyl-carrier-protein] reductase activity GSVIVG01008491001 1382388 1394519 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+. IEA GO:0004316 3-oxoacyl-[acyl-carrier-protein] reductase activity GSVIVG01008491001 1382388 1394519 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+. IEA GO:0004316 3-oxoacyl-[acyl-carrier-protein] reductase activity GSVIVG01008491001 1382388 1394519 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008491001 1382388 1394519 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008491001 1382388 1394519 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008491001 1382388 1394519 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008491001 1382388 1394519 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01008491001 1382388 1394519 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01008491001 1382388 1394519 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01008491001 1382388 1394519 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01008491001 1382388 1394519 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008491001 1382388 1394519 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008491001 1382388 1394519 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008491001 1382388 1394519 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008491001 1382388 1394519 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01008491001 1382388 1394519 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01008491001 1382388 1394519 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01008491001 1382388 1394519 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01017482001 9136745 9138318 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01017482001 9136745 9138318 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01037914001 6388280 6390420 GSVIVG01032696001 1450030 1452246 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01032696001 1450030 1452246 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01016997001 3297019 3303837 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016997001 3297019 3303837 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016997001 3297019 3303837 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016997001 3297019 3303837 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate. IEA GO:0004470 malic enzyme activity GSVIVG01016997001 3297019 3303837 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate. IEA GO:0004470 malic enzyme activity GSVIVG01016997001 3297019 3303837 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate. IEA GO:0004470 malic enzyme activity GSVIVG01016997001 3297019 3303837 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016997001 3297019 3303837 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016997001 3297019 3303837 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016997001 3297019 3303837 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016997001 3297019 3303837 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016997001 3297019 3303837 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016997001 3297019 3303837 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01016997001 3297019 3303837 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01016997001 3297019 3303837 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01016997001 3297019 3303837 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01016997001 3297019 3303837 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01016997001 3297019 3303837 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01016997001 3297019 3303837 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01016997001 3297019 3303837 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01016997001 3297019 3303837 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01015743001 16716643 16718686 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01016302001 5356551 5360892 GO:0008219 cell death A biological process that results in permanent cessation of all vital functions of a cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01029233001 18220060 18229561 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01029233001 18220060 18229561 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01029233001 18220060 18229561 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01029233001 18220060 18229561 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026208001 14142558 14157354 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01026208001 14142558 14157354 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01026208001 14142558 14157354 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01005158001 18828310 18832167 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01005158001 18828310 18832167 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01005158001 18828310 18832167 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01005158001 18828310 18832167 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024339001 1169138 1191078 GSVIVG01009562001 9433848 9437925 GSVIVG01015556001 4862914 4867036 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018056001 5874228 5876000 GSVIVG01027579001 15367161 15399138 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01027579001 15367161 15399138 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01027579001 15367161 15399138 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01027579001 15367161 15399138 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01027579001 15367161 15399138 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01027579001 15367161 15399138 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01027579001 15367161 15399138 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01027579001 15367161 15399138 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01027579001 15367161 15399138 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01004801001 17032 18918 GSVIVG01032365001 26743562 26745706 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01032365001 26743562 26745706 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01032365001 26743562 26745706 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01032365001 26743562 26745706 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01011946001 2754310 2765820 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain. IEA GO:0004177 aminopeptidase activity GSVIVG01011946001 2754310 2765820 GO:0009987 cellular process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. IEA Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain. IEA GO:0004177 aminopeptidase activity GSVIVG01011946001 2754310 2765820 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01011946001 2754310 2765820 GO:0009987 cellular process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01011946001 2754310 2765820 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008235 metalloexopeptidase activity GSVIVG01011946001 2754310 2765820 GO:0009987 cellular process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008235 metalloexopeptidase activity GSVIVG01011946001 2754310 2765820 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01011946001 2754310 2765820 GO:0009987 cellular process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01011946001 2754310 2765820 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01011946001 2754310 2765820 GO:0009987 cellular process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01011946001 2754310 2765820 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with a cobalt (Co) ion. IEA GO:0050897 cobalt ion binding GSVIVG01011946001 2754310 2765820 GO:0009987 cellular process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. IEA Interacting selectively and non-covalently with a cobalt (Co) ion. IEA GO:0050897 cobalt ion binding GSVIVG01013295001 399504 400172 GSVIVG01008584001 717752 722776 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01023075001 15762963 15766749 GSVIVG01025860001 11099866 11100975 GSVIVG01018935001 18542672 18546815 GSVIVG01005493001 40461393 40463143 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01005493001 40461393 40463143 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA Catalysis of the hydrolysis of ester linkages within nucleic acids. IEA GO:0004518 nuclease activity GSVIVG01013586001 21209343 21210050 GSVIVG01016991001 3229012 3244545 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016991001 3229012 3244545 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016991001 3229012 3244545 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01016991001 3229012 3244545 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01021490001 6067480 6076239 GSVIVG01036966001 9439067 9442128 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01036966001 9439067 9442128 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01036966001 9439067 9442128 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036966001 9439067 9442128 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017476001 8980342 8984264 GSVIVG01035820001 4639382 4640818 GSVIVG01027650001 14642837 14643970 GSVIVG01035866001 5036099 5039342 The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01034475001 20728900 20735286 GSVIVG01014040001 9660439 9665853 GSVIVG01030221001 10330216 10332233 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01030221001 10330216 10332233 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01030221001 10330216 10332233 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01030221001 10330216 10332233 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01026165001 13273708 13274785 GSVIVG01014731001 9051363 9053928 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GSVIVG01035010001 874709 876992 GSVIVG01035627001 2794884 2795466 GSVIVG01029857001 538475 541829 GSVIVG01038585001 21712144 21712399 GSVIVG01035793001 4389209 4409630 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0000159 protein phosphatase type 2A complex A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit. IEA Modulation of the activity of the enzyme protein phosphatase type 2A. IEA GO:0008601 protein phosphatase type 2A regulator activity GSVIVG01028741001 19238717 19239864 GSVIVG01013424001 553739 554202 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01012070001 1646113 1646190 GSVIVG01016110001 19142768 19147865 GSVIVG01016708001 515501 518780 GSVIVG01005030001 17381428 17383110 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01005030001 17381428 17383110 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01014582001 5376571 5377846 GSVIVG01015691001 15631095 15631942 GSVIVG01035172001 12680244 12742543 GO:0006012 galactose metabolic process The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + D-galactose = ADP + D-galactose 1-phosphate. IEA GO:0004335 galactokinase activity GSVIVG01035172001 12680244 12742543 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + D-galactose = ADP + D-galactose 1-phosphate. IEA GO:0004335 galactokinase activity GSVIVG01035172001 12680244 12742543 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + D-galactose = ADP + D-galactose 1-phosphate. IEA GO:0004335 galactokinase activity GSVIVG01035172001 12680244 12742543 GO:0046835 carbohydrate phosphorylation The process of introducing a phosphate group into a carbohydrate, any organic compound based on the general formula Cx(H2O)y. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + D-galactose = ADP + D-galactose 1-phosphate. IEA GO:0004335 galactokinase activity GSVIVG01035172001 12680244 12742543 GO:0006012 galactose metabolic process The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035172001 12680244 12742543 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035172001 12680244 12742543 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035172001 12680244 12742543 GO:0046835 carbohydrate phosphorylation The process of introducing a phosphate group into a carbohydrate, any organic compound based on the general formula Cx(H2O)y. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035172001 12680244 12742543 GO:0006012 galactose metabolic process The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01035172001 12680244 12742543 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01035172001 12680244 12742543 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01035172001 12680244 12742543 GO:0046835 carbohydrate phosphorylation The process of introducing a phosphate group into a carbohydrate, any organic compound based on the general formula Cx(H2O)y. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01035172001 12680244 12742543 GO:0006012 galactose metabolic process The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01035172001 12680244 12742543 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01035172001 12680244 12742543 GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01035172001 12680244 12742543 GO:0046835 carbohydrate phosphorylation The process of introducing a phosphate group into a carbohydrate, any organic compound based on the general formula Cx(H2O)y. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01032309001 14858551 14928989 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01032309001 14858551 14928989 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01032309001 14858551 14928989 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01032309001 14858551 14928989 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01032309001 14858551 14928989 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01032309001 14858551 14928989 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01030503001 6264462 6266803 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030503001 6264462 6266803 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01030503001 6264462 6266803 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01012630001 208806 220343 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. IEA GO:0008081 phosphoric diester hydrolase activity GSVIVG01014973001 13399162 13400570 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. IEA GO:0004364 glutathione transferase activity GSVIVG01035247001 11271684 11278138 GO:0006536 glutamate metabolic process The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035247001 11271684 11278138 GO:0019752 carboxylic acid metabolic process The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035247001 11271684 11278138 GO:0006536 glutamate metabolic process The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid. IEA Catalysis of the reaction: L-glutamate = 4-aminobutanoate + CO2. IEA GO:0004351 glutamate decarboxylase activity GSVIVG01035247001 11271684 11278138 GO:0019752 carboxylic acid metabolic process The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). IEA Catalysis of the reaction: L-glutamate = 4-aminobutanoate + CO2. IEA GO:0004351 glutamate decarboxylase activity GSVIVG01035247001 11271684 11278138 GO:0006536 glutamate metabolic process The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid. IEA Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. IEA GO:0016831 carboxy-lyase activity GSVIVG01035247001 11271684 11278138 GO:0019752 carboxylic acid metabolic process The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). IEA Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. IEA GO:0016831 carboxy-lyase activity GSVIVG01035247001 11271684 11278138 GO:0006536 glutamate metabolic process The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01035247001 11271684 11278138 GO:0019752 carboxylic acid metabolic process The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01029847001 360722 378060 GSVIVG01038248001 24617175 24654920 GSVIVG01018624001 12077244 12082552 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01018624001 12077244 12082552 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01018624001 12077244 12082552 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01018624001 12077244 12082552 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022703001 15297641 15306938 GSVIVG01027782001 7674753 7676135 GSVIVG01001595001 18213107 18223429 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0005886 plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01001595001 18213107 18223429 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01006788001 28518082 28518792 GSVIVG01022309001 18388791 18393563 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01022309001 18388791 18393563 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01022309001 18388791 18393563 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01022309001 18388791 18393563 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01022309001 18388791 18393563 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01022309001 18388791 18393563 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01022309001 18388791 18393563 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01022309001 18388791 18393563 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01022309001 18388791 18393563 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01022309001 18388791 18393563 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01022309001 18388791 18393563 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01022309001 18388791 18393563 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01022309001 18388791 18393563 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01022309001 18388791 18393563 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01022309001 18388791 18393563 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01022309001 18388791 18393563 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01022309001 18388791 18393563 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01022309001 18388791 18393563 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01022309001 18388791 18393563 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01022309001 18388791 18393563 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01022309001 18388791 18393563 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01022309001 18388791 18393563 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01022309001 18388791 18393563 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01022309001 18388791 18393563 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01019336001 861631 861900 GSVIVG01022327001 18532218 18533000 GSVIVG01022799001 16737479 16740699 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01022799001 16737479 16740699 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01022799001 16737479 16740699 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01011876001 3358784 3365292 GSVIVG01035408001 1068284 1074131 GO:0006544 glycine metabolic process The chemical reactions and pathways involving glycine, aminoethanoic acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035408001 1068284 1074131 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035408001 1068284 1074131 GO:0006544 glycine metabolic process The chemical reactions and pathways involving glycine, aminoethanoic acid. IEA Catalysis of the reaction: glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + CO2. IEA GO:0004375 glycine dehydrogenase (decarboxylating) activity GSVIVG01035408001 1068284 1074131 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + CO2. IEA GO:0004375 glycine dehydrogenase (decarboxylating) activity GSVIVG01035408001 1068284 1074131 GO:0006544 glycine metabolic process The chemical reactions and pathways involving glycine, aminoethanoic acid. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01035408001 1068284 1074131 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01032712001 1326308 1328069 GSVIVG01028101001 3804144 3819305 GSVIVG01000634001 20211561 20223527 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000634001 20211561 20223527 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000634001 20211561 20223527 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000634001 20211561 20223527 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030091001 9756400 9757530 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01008975001 3976069 3979749 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01008975001 3976069 3979749 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01019481001 990820 996189 GO:0006351 transcription, DNA-dependent The cellular synthesis of RNA on a template of DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019481001 990820 996189 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019481001 990820 996189 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019481001 990820 996189 GO:0006351 transcription, DNA-dependent The cellular synthesis of RNA on a template of DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01019481001 990820 996189 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01019481001 990820 996189 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01019481001 990820 996189 GO:0006351 transcription, DNA-dependent The cellular synthesis of RNA on a template of DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01019481001 990820 996189 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01019481001 990820 996189 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01019481001 990820 996189 GO:0006351 transcription, DNA-dependent The cellular synthesis of RNA on a template of DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01019481001 990820 996189 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01019481001 990820 996189 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01017772001 3341975 3348425 GSVIVG01016829001 1742056 1748568 GSVIVG01032063001 23101374 23102559 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01032063001 23101374 23102559 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01002675001 35818278 35821970 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01002675001 35818278 35821970 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032747001 1064580 1065653 GSVIVG01006689001 27553732 27561358 GO:0007585 respiratory gaseous exchange The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. IEA GO:0005740 mitochondrial envelope The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space. IEA GSVIVG01006689001 27553732 27561358 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005740 mitochondrial envelope The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space. IEA GSVIVG01009066001 4653690 4659570 GSVIVG01018225001 12954998 12955978 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01004098001 14777939 14798849 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01018325001 11039652 11043590 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01018325001 11039652 11043590 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01018325001 11039652 11043590 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01018325001 11039652 11043590 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01018325001 11039652 11043590 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01018325001 11039652 11043590 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01026336001 14226255 14231319 GSVIVG01009773001 11166503 11167953 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01030208001 10427098 10428761 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01030208001 10427098 10428761 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01027028001 18496035 18501265 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01004877001 16301608 16307985 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01004877001 16301608 16307985 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01004877001 16301608 16307985 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01004877001 16301608 16307985 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01004877001 16301608 16307985 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01004877001 16301608 16307985 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01004877001 16301608 16307985 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01004877001 16301608 16307985 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01004877001 16301608 16307985 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01004877001 16301608 16307985 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01004877001 16301608 16307985 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01004877001 16301608 16307985 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01004877001 16301608 16307985 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01004877001 16301608 16307985 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01004877001 16301608 16307985 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01004877001 16301608 16307985 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01004877001 16301608 16307985 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01004877001 16301608 16307985 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01004877001 16301608 16307985 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01004877001 16301608 16307985 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01022298001 18319771 18323218 GO:0006397 mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01022298001 18319771 18323218 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01022298001 18319771 18323218 GO:0006397 mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01022298001 18319771 18323218 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01022298001 18319771 18323218 GO:0006397 mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01022298001 18319771 18323218 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01022298001 18319771 18323218 GO:0006397 mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022298001 18319771 18323218 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022298001 18319771 18323218 GO:0006397 mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. IEA Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters. IEA GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters GSVIVG01022298001 18319771 18323218 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters. IEA GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters GSVIVG01017190001 5183864 5187635 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01031601001 18772178 18773897 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01031601001 18772178 18773897 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01031601001 18772178 18773897 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01031601001 18772178 18773897 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01031601001 18772178 18773897 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01031601001 18772178 18773897 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01031601001 18772178 18773897 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01031601001 18772178 18773897 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01001302001 5158144 5159790 GO:0008380 RNA splicing The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA. IEA GSVIVG01023633001 8246481 8247174 GSVIVG01038458001 12788226 12790813 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013737001 8038365 8044353 GSVIVG01019337001 856315 859552 GSVIVG01018780001 19932426 19981450 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01018780001 19932426 19981450 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01018780001 19932426 19981450 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01015737001 16649674 16650636 GSVIVG01023300001 19957158 19957843 GSVIVG01033519001 20046489 20051103 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01018600001 12483376 12486156 GSVIVG01002735001 36278828 36279944 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01002735001 36278828 36279944 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01002735001 36278828 36279944 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01002735001 36278828 36279944 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01002735001 36278828 36279944 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01002735001 36278828 36279944 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01002735001 36278828 36279944 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01002735001 36278828 36279944 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01023996001 1843279 1854839 GO:0006413 translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. IEA Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. IEA GO:0003743 translation initiation factor activity GSVIVG01033526001 20014129 20016421 GSVIVG01035900001 5486284 5510561 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01035900001 5486284 5510561 GO:0019538 protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01035900001 5486284 5510561 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01035900001 5486284 5510561 GO:0019538 protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01035900001 5486284 5510561 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01035900001 5486284 5510561 GO:0019538 protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01035900001 5486284 5510561 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035900001 5486284 5510561 GO:0019538 protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035900001 5486284 5510561 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035900001 5486284 5510561 GO:0019538 protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035900001 5486284 5510561 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01035900001 5486284 5510561 GO:0019538 protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01035900001 5486284 5510561 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01035900001 5486284 5510561 GO:0019538 protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01021812001 7051603 7058496 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021812001 7051603 7058496 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021812001 7051603 7058496 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01010443001 20661352 20663794 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01008595001 551030 552902 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with a mating-type factor pheromone to initiate a change in cell activity. IEA GO:0004932 mating-type factor pheromone receptor activity GSVIVG01008595001 551030 552902 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with a mating-type factor pheromone to initiate a change in cell activity. IEA GO:0004932 mating-type factor pheromone receptor activity GSVIVG01031846001 4854093 4857037 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01011429001 29579318 29589823 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: ADP-glucose + (1,4)-alpha-D-glucosyl(n) = ADP + (1,4)-alpha-D-glucosyl(n+1). IEA GO:0009011 starch synthase activity GSVIVG01011429001 29579318 29589823 GO:0009250 glucan biosynthetic process The chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues. IEA Catalysis of the reaction: ADP-glucose + (1,4)-alpha-D-glucosyl(n) = ADP + (1,4)-alpha-D-glucosyl(n+1). IEA GO:0009011 starch synthase activity GSVIVG01000585001 6831274 6842487 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01034934001 234216 234679 GSVIVG01024449001 2714684 2733044 GSVIVG01035724001 3680723 3684714 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01035724001 3680723 3684714 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01030843001 17427404 17455290 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01030843001 17427404 17455290 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with double-stranded RNA. IEA GO:0003725 double-stranded RNA binding GSVIVG01020637001 3588840 3596766 Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. IEA GO:0008171 O-methyltransferase activity GSVIVG01011110001 1493493 1498383 GSVIVG01024006001 1778145 1786685 GSVIVG01008311001 3359968 3361323 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008311001 3359968 3361323 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01005839001 22179929 22181231 GSVIVG01017096001 4127847 4133231 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01017096001 4127847 4133231 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01017096001 4127847 4133231 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01017096001 4127847 4133231 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017096001 4127847 4133231 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01033084001 25604963 25605412 GO:0006605 protein targeting The process of targeting specific proteins to particular membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01033084001 25604963 25605412 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01033084001 25604963 25605412 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01012253001 109279 110282 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA GSVIVG01026456001 23278013 23287916 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01026456001 23278013 23287916 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01019309001 1454693 1459049 GSVIVG01028818001 18398945 18408373 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01007663001 10736576 10738749 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA GSVIVG01011372001 29069039 29071592 GO:0016043 cellular component organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cellular component. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01011372001 29069039 29071592 GO:0030036 actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01029902001 1240889 1259995 GO:0006909 phagocytosis The process whereby phagocytes engulf external particulate material. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles. IEA GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA GSVIVG01026557001 21881937 21882484 GSVIVG01003773001 12529001 12531922 GO:0009416 response to light stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01003773001 12529001 12531922 GO:0009416 response to light stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01037340001 15456985 15458948 GSVIVG01020752001 2348150 2350401 GSVIVG01032579001 28545588 28558012 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01029720001 13721467 13758979 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01029720001 13721467 13758979 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01029720001 13721467 13758979 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01029720001 13721467 13758979 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01029720001 13721467 13758979 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01029720001 13721467 13758979 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01029720001 13721467 13758979 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029720001 13721467 13758979 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029720001 13721467 13758979 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029720001 13721467 13758979 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029720001 13721467 13758979 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01029720001 13721467 13758979 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01020127001 10078132 10080444 GSVIVG01009214001 6286068 6286564 GSVIVG01018077001 6257694 6264555 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01018077001 6257694 6264555 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01018077001 6257694 6264555 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01018077001 6257694 6264555 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01018077001 6257694 6264555 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01018077001 6257694 6264555 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01011482001 29967958 29969925 GSVIVG01038638001 21290996 21291719 GSVIVG01030203001 10508447 10510197 GSVIVG01011912001 3048922 3049971 GSVIVG01023544001 9898960 9900018 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01023544001 9898960 9900018 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01024679001 7819203 7823853 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01024679001 7819203 7823853 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01024679001 7819203 7823853 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01024679001 7819203 7823853 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037528001 12136057 12193003 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin. IEA GO:0004221 ubiquitin thiolesterase activity GSVIVG01032684001 1559166 1559953 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032684001 1559166 1559953 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01032684001 1559166 1559953 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01014396001 3355217 3356111 GSVIVG01021083001 1304688 1305449 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01021083001 1304688 1305449 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01021083001 1304688 1305449 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01021083001 1304688 1305449 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01000871001 3258371 3265810 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000871001 3258371 3265810 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000871001 3258371 3265810 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000871001 3258371 3265810 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015308001 2548079 2561422 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015308001 2548079 2561422 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. IEA GO:0004722 protein serine/threonine phosphatase activity GSVIVG01017687001 2656161 2658162 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Stops, prevents or reduces the activity of an enzyme. IEA GO:0004857 enzyme inhibitor activity GSVIVG01017687001 2656161 2658162 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the reaction: pectin + n H2O = n methanol + pectate. IEA GO:0030599 pectinesterase activity GSVIVG01026655001 20659903 20663897 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: 2 H2O2 = O2 + 2 H2O. IEA GO:0004096 catalase activity GSVIVG01026655001 20659903 20663897 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2 H2O2 = O2 + 2 H2O. IEA GO:0004096 catalase activity GSVIVG01010442001 20653444 20660585 GSVIVG01021784001 7458563 7470778 GSVIVG01023722001 10102895 10105059 GSVIVG01022624001 13673928 13674737 GSVIVG01026103001 24530121 24534930 GSVIVG01012230001 390750 395260 GSVIVG01011405001 29381546 29386786 GSVIVG01003267001 8639324 8641281 GSVIVG01010932001 15427916 15429283 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01010932001 15427916 15429283 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01007679001 10560060 10564743 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007679001 10560060 10564743 Catalysis of the elimination of H2S or substituted H2S. IEA GO:0016846 carbon-sulfur lyase activity GSVIVG01007679001 10560060 10564743 Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01026719001 5393012 5449785 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030127 COPII vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01026719001 5393012 5449785 GO:0006888 ER to Golgi vesicle-mediated transport The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi. IEA GO:0030127 COPII vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01026719001 5393012 5449785 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030127 COPII vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01026719001 5393012 5449785 GO:0006888 ER to Golgi vesicle-mediated transport The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi. IEA GO:0030127 COPII vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01019394001 281175 287055 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01021891001 5986592 5987223 GSVIVG01038384001 11541665 11547689 GSVIVG01030507001 6295829 6299067 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030507001 6295829 6299067 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01014245001 1928971 1945302 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01014245001 1928971 1945302 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01014245001 1928971 1945302 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01014245001 1928971 1945302 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01014245001 1928971 1945302 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01014245001 1928971 1945302 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01014245001 1928971 1945302 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01014245001 1928971 1945302 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01014245001 1928971 1945302 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01014245001 1928971 1945302 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01014245001 1928971 1945302 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01014245001 1928971 1945302 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01014245001 1928971 1945302 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01014245001 1928971 1945302 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01014245001 1928971 1945302 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01014245001 1928971 1945302 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01014245001 1928971 1945302 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01014245001 1928971 1945302 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01014245001 1928971 1945302 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01014245001 1928971 1945302 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01014245001 1928971 1945302 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01014245001 1928971 1945302 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01014245001 1928971 1945302 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01014245001 1928971 1945302 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01020459001 19093051 19093640 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01020459001 19093051 19093640 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01020459001 19093051 19093640 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01020459001 19093051 19093640 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01032462001 27671065 27684285 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01032462001 27671065 27684285 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01032462001 27671065 27684285 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01032462001 27671065 27684285 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01032462001 27671065 27684285 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01032462001 27671065 27684285 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01032462001 27671065 27684285 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032462001 27671065 27684285 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032462001 27671065 27684285 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032462001 27671065 27684285 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032462001 27671065 27684285 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032462001 27671065 27684285 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032462001 27671065 27684285 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the movement of phospholipids from one membrane face to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP. IEA GO:0004012 phospholipid-translocating ATPase activity GSVIVG01032462001 27671065 27684285 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the movement of phospholipids from one membrane face to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP. IEA GO:0004012 phospholipid-translocating ATPase activity GSVIVG01032462001 27671065 27684285 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the movement of phospholipids from one membrane face to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP. IEA GO:0004012 phospholipid-translocating ATPase activity GSVIVG01032462001 27671065 27684285 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the movement of phospholipids from one membrane face to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP. IEA GO:0004012 phospholipid-translocating ATPase activity GSVIVG01032462001 27671065 27684285 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the movement of phospholipids from one membrane face to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP. IEA GO:0004012 phospholipid-translocating ATPase activity GSVIVG01032462001 27671065 27684285 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the movement of phospholipids from one membrane face to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP. IEA GO:0004012 phospholipid-translocating ATPase activity GSVIVG01032462001 27671065 27684285 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032462001 27671065 27684285 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032462001 27671065 27684285 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032462001 27671065 27684285 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032462001 27671065 27684285 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032462001 27671065 27684285 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032462001 27671065 27684285 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01032462001 27671065 27684285 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01032462001 27671065 27684285 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01032462001 27671065 27684285 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01032462001 27671065 27684285 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01032462001 27671065 27684285 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01032462001 27671065 27684285 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01032462001 27671065 27684285 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01032462001 27671065 27684285 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01032462001 27671065 27684285 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01032462001 27671065 27684285 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01032462001 27671065 27684285 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01022829001 18978545 18982936 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035347001 669070 674844 GSVIVG01001786001 3085323 3128095 GSVIVG01028807001 18554741 18556254 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01028807001 18554741 18556254 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01028807001 18554741 18556254 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01003604001 11190042 11194756 GSVIVG01024530001 9135653 9136192 GSVIVG01025621001 13529180 13535002 GO:0006796 phosphate metabolic process The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01025621001 13529180 13535002 GO:0006796 phosphate metabolic process The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: diphosphate + H2O = 2 phosphate. IEA GO:0004427 inorganic diphosphatase activity GSVIVG01012870001 6382509 6387386 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01001971001 5915392 5917479 GSVIVG01018722001 20392624 20394981 GSVIVG01015495001 4212263 4213031 GSVIVG01034906001 16302857 16307318 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01034906001 16302857 16307318 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034906001 16302857 16307318 Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01034906001 16302857 16307318 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01008996001 4137998 4140727 GO:0005615 extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. IEA GSVIVG01033877001 17073833 17077693 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01033877001 17073833 17077693 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01037157001 28472201 28499501 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030556001 6703427 6707062 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01034981001 668029 671203 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01011989001 2374461 2375324 GSVIVG01037882001 6785297 6787059 GSVIVG01029029001 10933221 10936995 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01015260001 2170747 2172957 GSVIVG01013854001 5345035 5346423 GO:0016568 chromatin modification The alteration of DNA or protein in chromatin, which may result in changing the chromatin structure. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01013854001 5345035 5346423 GO:0016568 chromatin modification The alteration of DNA or protein in chromatin, which may result in changing the chromatin structure. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives. IEA GO:0018024 histone-lysine N-methyltransferase activity GSVIVG01013992001 8618850 8629956 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016299001 5376846 5389085 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016299001 5376846 5389085 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01005255001 19910522 19914385 GSVIVG01024498001 3348260 3349973 GSVIVG01025106001 4420434 4422979 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01037178001 28286787 28287068 GSVIVG01033376001 21108442 21110576 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GSVIVG01003802001 275520 277792 GSVIVG01017844001 3968917 3972344 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01017230001 5700858 5706778 GSVIVG01024196001 430289 436670 GSVIVG01038223001 24463136 24466160 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01038223001 24463136 24466160 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01038223001 24463136 24466160 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01038223001 24463136 24466160 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01038223001 24463136 24466160 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01038223001 24463136 24466160 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01038223001 24463136 24466160 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01038223001 24463136 24466160 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01026334001 14185503 14185948 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01026334001 14185503 14185948 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01029987001 2775588 2784848 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01029987001 2775588 2784848 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01029987001 2775588 2784848 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01025816001 11543729 11547592 GO:0001503 ossification The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance. IEA GSVIVG01025816001 11543729 11547592 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GSVIVG01014707001 8871322 8877907 GSVIVG01008146001 5379736 5389939 Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate. IEA GO:0008146 sulfotransferase activity GSVIVG01031222001 1065201 1065380 GSVIVG01021718001 9988941 9989369 GSVIVG01036767001 22805628 22810184 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036767001 22805628 22810184 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036767001 22805628 22810184 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036767001 22805628 22810184 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029848001 386967 393753 GSVIVG01022033001 4065043 4086276 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01022033001 4065043 4086276 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01022033001 4065043 4086276 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01022033001 4065043 4086276 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01007616001 11182221 11182762 GSVIVG01013696001 2750356 2751136 GSVIVG01004729001 15611301 15612462 GSVIVG01005989001 23141765 23143934 GSVIVG01011660001 5477593 5485134 GO:0009245 lipid A biosynthetic process The chemical reactions and pathways resulting in the formation of lipid A, the glycolipid moiety of bacterial lipopolysaccharides, consisting of six fatty acyl chains linked to two glucosamine residues. IEA Catalysis of the removal of an acetyl moiety from the 2-N position of glucosamine in the lipid A precursor UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine. IEA GO:0008759 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity GSVIVG01037121001 28928371 28931148 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid. IEA GO:0008378 galactosyltransferase activity GSVIVG01028332001 6231033 6235272 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028332001 6231033 6235272 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028332001 6231033 6235272 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028332001 6231033 6235272 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028332001 6231033 6235272 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028332001 6231033 6235272 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028332001 6231033 6235272 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028332001 6231033 6235272 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028332001 6231033 6235272 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028332001 6231033 6235272 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028332001 6231033 6235272 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028332001 6231033 6235272 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028332001 6231033 6235272 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01028332001 6231033 6235272 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01028332001 6231033 6235272 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01028332001 6231033 6235272 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01028332001 6231033 6235272 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01028332001 6231033 6235272 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01028332001 6231033 6235272 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. IEA GO:0016615 malate dehydrogenase activity GSVIVG01028332001 6231033 6235272 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. IEA GO:0016615 malate dehydrogenase activity GSVIVG01028332001 6231033 6235272 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. IEA GO:0016615 malate dehydrogenase activity GSVIVG01028332001 6231033 6235272 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. IEA GO:0016615 malate dehydrogenase activity GSVIVG01028332001 6231033 6235272 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. IEA GO:0016615 malate dehydrogenase activity GSVIVG01028332001 6231033 6235272 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. IEA GO:0016615 malate dehydrogenase activity GSVIVG01028332001 6231033 6235272 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01028332001 6231033 6235272 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01028332001 6231033 6235272 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01028332001 6231033 6235272 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01028332001 6231033 6235272 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01028332001 6231033 6235272 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01028332001 6231033 6235272 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids. IEA GO:0030060 L-malate dehydrogenase activity GSVIVG01028332001 6231033 6235272 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids. IEA GO:0030060 L-malate dehydrogenase activity GSVIVG01028332001 6231033 6235272 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids. IEA GO:0030060 L-malate dehydrogenase activity GSVIVG01028332001 6231033 6235272 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids. IEA GO:0030060 L-malate dehydrogenase activity GSVIVG01028332001 6231033 6235272 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids. IEA GO:0030060 L-malate dehydrogenase activity GSVIVG01028332001 6231033 6235272 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids. IEA GO:0030060 L-malate dehydrogenase activity GSVIVG01026926001 19347779 19350440 GSVIVG01015774001 17293808 17305617 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01015774001 17293808 17305617 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01000043001 3013561 3017124 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01000043001 3013561 3017124 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01000043001 3013561 3017124 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01000043001 3013561 3017124 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01000043001 3013561 3017124 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01000043001 3013561 3017124 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033570001 19674517 19690585 GSVIVG01030980001 20212889 20219509 GSVIVG01011671001 5344900 5350070 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01011671001 5344900 5350070 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01025155001 3914148 3919039 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01010476001 20923225 20925144 GSVIVG01011969001 2525940 2527795 GSVIVG01014773001 9491542 9495825 GSVIVG01038092001 23448149 23451578 GSVIVG01011002001 2301635 2305280 GSVIVG01009568001 9497807 9498340 Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01009568001 9497807 9498340 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01023988001 1913089 1913969 GSVIVG01029873001 875613 882448 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. IEA GO:0008080 N-acetyltransferase activity GSVIVG01014792001 9782709 9783380 GSVIVG01017444001 8605460 8610408 GSVIVG01023289001 20065567 20066543 GSVIVG01035334001 557911 563227 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GSVIVG01018192001 13403670 13403834 GSVIVG01018352001 10655383 10660527 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007131001 30302465 30305176 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016406001 4186201 4187490 GSVIVG01011994001 2352041 2356540 GSVIVG01035953001 6408875 6414336 Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01003137001 7559136 7562607 GSVIVG01025859001 11103917 11115825 GSVIVG01004323001 38099330 38101339 GSVIVG01020164001 9525063 9530545 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01020164001 9525063 9530545 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01038249001 24655057 24664205 GSVIVG01023818001 3219636 3221351 GSVIVG01028316001 6056986 6058099 GSVIVG01012318001 13838374 13838634 GSVIVG01031923001 5433670 5437872 GSVIVG01013744001 7989003 7990113 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01037277001 16555046 16558576 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01037277001 16555046 16558576 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01025931001 27102063 27102260 GSVIVG01035291001 105732 111628 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035291001 105732 111628 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035291001 105732 111628 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035291001 105732 111628 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate. IEA GO:0004470 malic enzyme activity GSVIVG01035291001 105732 111628 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate. IEA GO:0004470 malic enzyme activity GSVIVG01035291001 105732 111628 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate. IEA GO:0004470 malic enzyme activity GSVIVG01035291001 105732 111628 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035291001 105732 111628 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035291001 105732 111628 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035291001 105732 111628 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01035291001 105732 111628 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01035291001 105732 111628 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01035291001 105732 111628 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01035291001 105732 111628 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01035291001 105732 111628 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01035291001 105732 111628 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01035291001 105732 111628 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01035291001 105732 111628 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01035291001 105732 111628 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01035291001 105732 111628 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01035291001 105732 111628 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01026758001 6367393 6401591 GSVIVG01016121001 19461163 19469364 GSVIVG01010922001 15655460 15663113 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01010922001 15655460 15663113 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01026678001 4646288 4652596 GSVIVG01017296001 6451601 6452529 GSVIVG01030113001 9975429 9979232 GSVIVG01013501001 1946951 1947935 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01013501001 1946951 1947935 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01015540001 4677758 4681200 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01015540001 4677758 4681200 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01006161001 42295203 42296806 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01000598001 6653070 6670306 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000598001 6653070 6670306 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000598001 6653070 6670306 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000598001 6653070 6670306 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01000598001 6653070 6670306 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01000598001 6653070 6670306 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01000598001 6653070 6670306 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01000598001 6653070 6670306 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01000598001 6653070 6670306 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01000598001 6653070 6670306 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01000598001 6653070 6670306 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01000598001 6653070 6670306 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01027984001 2993094 2996351 GO:0006772 thiamin metabolic process The chemical reactions and pathways involving thiamin (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver. IEA Catalysis of the reaction: ATP + thiamin = AMP + thiamin diphosphate. IEA GO:0004788 thiamin diphosphokinase activity GSVIVG01027984001 2993094 2996351 GO:0009229 thiamin diphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of thiamin diphosphate, a derivative of thiamin (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle. IEA Catalysis of the reaction: ATP + thiamin = AMP + thiamin diphosphate. IEA GO:0004788 thiamin diphosphokinase activity GSVIVG01027984001 2993094 2996351 GO:0006772 thiamin metabolic process The chemical reactions and pathways involving thiamin (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027984001 2993094 2996351 GO:0009229 thiamin diphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of thiamin diphosphate, a derivative of thiamin (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010633001 15754260 15761055 GSVIVG01038512001 10807577 10824893 GSVIVG01037570001 10993012 10995410 GSVIVG01030866001 17967993 17969479 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01003439001 15058884 15059984 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003439001 15058884 15059984 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003439001 15058884 15059984 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003439001 15058884 15059984 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003439001 15058884 15059984 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003439001 15058884 15059984 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003439001 15058884 15059984 GO:0015693 magnesium ion transport The directed movement of magnesium (Mg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003439001 15058884 15059984 GO:0015693 magnesium ion transport The directed movement of magnesium (Mg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003439001 15058884 15059984 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003439001 15058884 15059984 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003439001 15058884 15059984 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003439001 15058884 15059984 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003439001 15058884 15059984 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003439001 15058884 15059984 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003439001 15058884 15059984 GO:0015693 magnesium ion transport The directed movement of magnesium (Mg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003439001 15058884 15059984 GO:0015693 magnesium ion transport The directed movement of magnesium (Mg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003439001 15058884 15059984 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mg2+(out) = ADP + phosphate + Mg2+(in). IEA GO:0015444 magnesium-importing ATPase activity GSVIVG01003439001 15058884 15059984 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mg2+(out) = ADP + phosphate + Mg2+(in). IEA GO:0015444 magnesium-importing ATPase activity GSVIVG01003439001 15058884 15059984 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mg2+(out) = ADP + phosphate + Mg2+(in). IEA GO:0015444 magnesium-importing ATPase activity GSVIVG01003439001 15058884 15059984 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mg2+(out) = ADP + phosphate + Mg2+(in). IEA GO:0015444 magnesium-importing ATPase activity GSVIVG01003439001 15058884 15059984 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mg2+(out) = ADP + phosphate + Mg2+(in). IEA GO:0015444 magnesium-importing ATPase activity GSVIVG01003439001 15058884 15059984 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mg2+(out) = ADP + phosphate + Mg2+(in). IEA GO:0015444 magnesium-importing ATPase activity GSVIVG01003439001 15058884 15059984 GO:0015693 magnesium ion transport The directed movement of magnesium (Mg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mg2+(out) = ADP + phosphate + Mg2+(in). IEA GO:0015444 magnesium-importing ATPase activity GSVIVG01003439001 15058884 15059984 GO:0015693 magnesium ion transport The directed movement of magnesium (Mg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mg2+(out) = ADP + phosphate + Mg2+(in). IEA GO:0015444 magnesium-importing ATPase activity GSVIVG01003439001 15058884 15059984 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01003439001 15058884 15059984 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01003439001 15058884 15059984 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01003439001 15058884 15059984 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01003439001 15058884 15059984 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01003439001 15058884 15059984 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01003439001 15058884 15059984 GO:0015693 magnesium ion transport The directed movement of magnesium (Mg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01003439001 15058884 15059984 GO:0015693 magnesium ion transport The directed movement of magnesium (Mg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01017885001 4315656 4317278 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA Catalysis of the reaction: isopentenyl diphosphate + tRNA = diphosphate + tRNA containing 6-isopentenyladenosine. IEA GO:0004811 tRNA isopentenyltransferase activity GSVIVG01017885001 4315656 4317278 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01005820001 22095725 22095790 GSVIVG01030548001 6632481 6643285 GSVIVG01035684001 3297143 3326185 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01035684001 3297143 3326185 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01035684001 3297143 3326185 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035684001 3297143 3326185 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and primer. IEA GO:0003887 DNA-directed DNA polymerase activity GSVIVG01035684001 3297143 3326185 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01035684001 3297143 3326185 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035684001 3297143 3326185 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035684001 3297143 3326185 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01035684001 3297143 3326185 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01037793001 7903958 7934080 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004185 serine-type carboxypeptidase activity GSVIVG01008998001 4148991 4155240 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01008802001 2231117 2244484 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01008802001 2231117 2244484 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01030358001 4943538 4944740 GSVIVG01029144001 19239302 19241166 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01029144001 19239302 19241166 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01029144001 19239302 19241166 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01029144001 19239302 19241166 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01034730001 8549063 8549710 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01034730001 8549063 8549710 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01034730001 8549063 8549710 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01034730001 8549063 8549710 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01034730001 8549063 8549710 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01034730001 8549063 8549710 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01031159001 1627262 1632821 GSVIVG01025994001 26156224 26160481 GSVIVG01015955001 16111382 16111655 GSVIVG01022883001 18390381 18391477 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004185 serine-type carboxypeptidase activity GSVIVG01037205001 27983868 27985625 GSVIVG01011532001 12946348 12964317 GSVIVG01027116001 17711586 17712448 GSVIVG01020143001 9882707 9887762 GSVIVG01038644001 21243320 21244892 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004197 cysteine-type endopeptidase activity GSVIVG01038644001 21243320 21244892 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004197 cysteine-type endopeptidase activity GSVIVG01038644001 21243320 21244892 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004197 cysteine-type endopeptidase activity GSVIVG01038644001 21243320 21244892 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038644001 21243320 21244892 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038644001 21243320 21244892 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038644001 21243320 21244892 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01038644001 21243320 21244892 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01038644001 21243320 21244892 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01038644001 21243320 21244892 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01038644001 21243320 21244892 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01038644001 21243320 21244892 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01030171001 10866529 10869614 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01030171001 10866529 10869614 GO:0006354 RNA elongation The extension of an RNA molecule after transcription initiation by the addition of ribonucleotides catalyzed by an RNA polymerase. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01030171001 10866529 10869614 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01030171001 10866529 10869614 GO:0006357 regulation of transcription from RNA polymerase II promoter Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01030171001 10866529 10869614 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01030171001 10866529 10869614 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01030171001 10866529 10869614 GO:0006354 RNA elongation The extension of an RNA molecule after transcription initiation by the addition of ribonucleotides catalyzed by an RNA polymerase. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01030171001 10866529 10869614 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01030171001 10866529 10869614 GO:0006357 regulation of transcription from RNA polymerase II promoter Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01030171001 10866529 10869614 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01030171001 10866529 10869614 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Functions to initiate or regulate RNA polymerase II transcription. IEA GO:0003702 RNA polymerase II transcription factor activity GSVIVG01030171001 10866529 10869614 GO:0006354 RNA elongation The extension of an RNA molecule after transcription initiation by the addition of ribonucleotides catalyzed by an RNA polymerase. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Functions to initiate or regulate RNA polymerase II transcription. IEA GO:0003702 RNA polymerase II transcription factor activity GSVIVG01030171001 10866529 10869614 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Functions to initiate or regulate RNA polymerase II transcription. IEA GO:0003702 RNA polymerase II transcription factor activity GSVIVG01030171001 10866529 10869614 GO:0006357 regulation of transcription from RNA polymerase II promoter Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Functions to initiate or regulate RNA polymerase II transcription. IEA GO:0003702 RNA polymerase II transcription factor activity GSVIVG01030171001 10866529 10869614 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Functions to initiate or regulate RNA polymerase II transcription. IEA GO:0003702 RNA polymerase II transcription factor activity GSVIVG01030171001 10866529 10869614 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule following transcription initiation. IEA GO:0003711 transcription elongation regulator activity GSVIVG01030171001 10866529 10869614 GO:0006354 RNA elongation The extension of an RNA molecule after transcription initiation by the addition of ribonucleotides catalyzed by an RNA polymerase. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule following transcription initiation. IEA GO:0003711 transcription elongation regulator activity GSVIVG01030171001 10866529 10869614 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule following transcription initiation. IEA GO:0003711 transcription elongation regulator activity GSVIVG01030171001 10866529 10869614 GO:0006357 regulation of transcription from RNA polymerase II promoter Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule following transcription initiation. IEA GO:0003711 transcription elongation regulator activity GSVIVG01030171001 10866529 10869614 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule following transcription initiation. IEA GO:0003711 transcription elongation regulator activity GSVIVG01030171001 10866529 10869614 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Functions in chain elongation during polypeptide synthesis at the ribosome. IEA GO:0003746 translation elongation factor activity GSVIVG01030171001 10866529 10869614 GO:0006354 RNA elongation The extension of an RNA molecule after transcription initiation by the addition of ribonucleotides catalyzed by an RNA polymerase. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Functions in chain elongation during polypeptide synthesis at the ribosome. IEA GO:0003746 translation elongation factor activity GSVIVG01030171001 10866529 10869614 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Functions in chain elongation during polypeptide synthesis at the ribosome. IEA GO:0003746 translation elongation factor activity GSVIVG01030171001 10866529 10869614 GO:0006357 regulation of transcription from RNA polymerase II promoter Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Functions in chain elongation during polypeptide synthesis at the ribosome. IEA GO:0003746 translation elongation factor activity GSVIVG01030171001 10866529 10869614 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Functions in chain elongation during polypeptide synthesis at the ribosome. IEA GO:0003746 translation elongation factor activity GSVIVG01030171001 10866529 10869614 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030171001 10866529 10869614 GO:0006354 RNA elongation The extension of an RNA molecule after transcription initiation by the addition of ribonucleotides catalyzed by an RNA polymerase. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030171001 10866529 10869614 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030171001 10866529 10869614 GO:0006357 regulation of transcription from RNA polymerase II promoter Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030171001 10866529 10869614 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030171001 10866529 10869614 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01030171001 10866529 10869614 GO:0006354 RNA elongation The extension of an RNA molecule after transcription initiation by the addition of ribonucleotides catalyzed by an RNA polymerase. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01030171001 10866529 10869614 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01030171001 10866529 10869614 GO:0006357 regulation of transcription from RNA polymerase II promoter Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01030171001 10866529 10869614 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01030171001 10866529 10869614 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01030171001 10866529 10869614 GO:0006354 RNA elongation The extension of an RNA molecule after transcription initiation by the addition of ribonucleotides catalyzed by an RNA polymerase. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01030171001 10866529 10869614 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01030171001 10866529 10869614 GO:0006357 regulation of transcription from RNA polymerase II promoter Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01030171001 10866529 10869614 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01004000001 14169520 14189581 GO:0000228 nuclear chromosome A chromosome found in the nucleus of a eukaryotic cell. IEA GSVIVG01009124001 5290465 5293634 GSVIVG01029307001 17156756 17159187 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01026213001 14216256 14217965 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026213001 14216256 14217965 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026213001 14216256 14217965 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01026213001 14216256 14217965 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01016704001 478229 482971 GSVIVG01013423001 565468 568841 GSVIVG01001448001 21105971 21114048 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01001448001 21105971 21114048 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01001448001 21105971 21114048 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001448001 21105971 21114048 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010337001 19601975 19607050 GSVIVG01032581001 28565013 28567439 GSVIVG01031912001 5320559 5322555 GSVIVG01034903001 16285607 16288125 GO:0019752 carboxylic acid metabolic process The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01034903001 16285607 16288125 GO:0019752 carboxylic acid metabolic process The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01034903001 16285607 16288125 GO:0019752 carboxylic acid metabolic process The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). IEA Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. IEA GO:0016831 carboxy-lyase activity GSVIVG01034903001 16285607 16288125 GO:0019752 carboxylic acid metabolic process The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01031996001 23685406 23685612 GSVIVG01024284001 534928 537177 GSVIVG01035986001 6844647 6867478 GSVIVG01026922001 19379225 19386528 GO:0000272 polysaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026922001 19379225 19386528 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026922001 19379225 19386528 GO:0000272 polysaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages. IEA Catalysis of the hydrolysis of 1,4-alpha-glucosidic linkages in polysaccharides so as to remove successive maltose units from the non-reducing ends of the chains. IEA GO:0016161 beta-amylase activity GSVIVG01026922001 19379225 19386528 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of 1,4-alpha-glucosidic linkages in polysaccharides so as to remove successive maltose units from the non-reducing ends of the chains. IEA GO:0016161 beta-amylase activity GSVIVG01026922001 19379225 19386528 GO:0000272 polysaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01026922001 19379225 19386528 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01021282001 3402601 3416864 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01021282001 3402601 3416864 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01021282001 3402601 3416864 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01021282001 3402601 3416864 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01021282001 3402601 3416864 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007918001 7531886 7537040 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01015120001 1178837 1181808 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01009954001 12776646 12781444 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01009954001 12776646 12781444 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds. IEA GO:0015035 protein disulfide oxidoreductase activity GSVIVG01006216001 23734583 23737044 GSVIVG01038511001 10777679 10805376 GSVIVG01033863001 17167524 17169413 GSVIVG01036598001 18965464 19000140 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA GSVIVG01033699001 18503840 18505329 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01005834001 22136233 22149165 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01018183001 13465861 13469630 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01018183001 13465861 13469630 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01018183001 13465861 13469630 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01021137001 1754174 1758300 GSVIVG01015595001 5365566 5365766 GSVIVG01032729001 1211401 1213914 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01032729001 1211401 1213914 Catalysis of the hydrolysis of ester linkages within nucleic acids. IEA GO:0004518 nuclease activity GSVIVG01032729001 1211401 1213914 Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01019442001 709763 719214 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01019442001 709763 719214 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019442001 709763 719214 Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01019442001 709763 719214 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01000194001 16022880 16024845 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01000194001 16022880 16024845 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01000194001 16022880 16024845 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01000194001 16022880 16024845 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01038660001 21144714 21150818 GSVIVG01030572001 6838847 6843544 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar. IEA GO:0008375 acetylglucosaminyltransferase activity GSVIVG01035009001 871762 873594 GSVIVG01036243001 8193635 8198518 GSVIVG01022647001 14046628 14071572 GSVIVG01032862001 141971 146044 GSVIVG01021150001 1855205 1864690 GSVIVG01033742001 18196226 18203602 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01033742001 18196226 18203602 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01033742001 18196226 18203602 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01033742001 18196226 18203602 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033499001 20227215 20232778 GSVIVG01027404001 17005385 17007393 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01027404001 17005385 17007393 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01027404001 17005385 17007393 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01027404001 17005385 17007393 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01026349001 14598141 14599841 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01026349001 14598141 14599841 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01026279001 15407362 15446371 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01026279001 15407362 15446371 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01025577001 13935875 13936621 GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA GSVIVG01016495001 3410208 3420366 GSVIVG01024852001 6476897 6486416 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. IEA GO:0004364 glutathione transferase activity GSVIVG01028415001 7357498 7358061 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005741 mitochondrial outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope. IEA GSVIVG01023661001 8697821 8703599 GSVIVG01005673001 21119639 21120514 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01016456001 3719037 3728106 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01016456001 3719037 3728106 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01016456001 3719037 3728106 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01016456001 3719037 3728106 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01011113001 1474333 1479057 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000882001 3389824 3392571 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000882001 3389824 3392571 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000882001 3389824 3392571 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000882001 3389824 3392571 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007799001 8903187 8905249 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01018831001 19495079 19495418 GSVIVG01038075001 17459712 17467129 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GSVIVG01013528001 2387587 2388318 GSVIVG01009685001 10446104 10477665 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01009685001 10446104 10477665 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01009685001 10446104 10477665 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01009685001 10446104 10477665 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023358001 19344563 19346864 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01023358001 19344563 19346864 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01023358001 19344563 19346864 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01023358001 19344563 19346864 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033326001 21465468 21479130 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01018740001 20281250 20288177 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01018740001 20281250 20288177 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01018740001 20281250 20288177 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01018740001 20281250 20288177 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: 2 H2O2 = O2 + 2 H2O. IEA GO:0004096 catalase activity GSVIVG01018740001 20281250 20288177 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: 2 H2O2 = O2 + 2 H2O. IEA GO:0004096 catalase activity GSVIVG01018740001 20281250 20288177 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: 2 H2O2 = O2 + 2 H2O. IEA GO:0004096 catalase activity GSVIVG01018740001 20281250 20288177 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01018740001 20281250 20288177 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01018740001 20281250 20288177 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01018740001 20281250 20288177 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01018740001 20281250 20288177 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01018740001 20281250 20288177 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01022420001 19944675 19948121 GSVIVG01035913001 5719505 5720985 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01035913001 5719505 5720985 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01012807001 5580210 5582473 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01019514001 1244909 1246172 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01019514001 1244909 1246172 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01019514001 1244909 1246172 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01019514001 1244909 1246172 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024008001 1771005 1775813 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01021014001 15301392 15303247 Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01031233001 1002908 1006534 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01031233001 1002908 1006534 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031233001 1002908 1006534 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate in the presence of single- or double-stranded DNA; drives another reaction. IEA GO:0008094 DNA-dependent ATPase activity GSVIVG01027425001 16831301 16836141 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01027425001 16831301 16836141 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01019410001 433948 435565 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01036337001 3922995 3924217 GSVIVG01001128001 22845052 22853689 GO:0006006 glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001128001 22845052 22853689 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001128001 22845052 22853689 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001128001 22845052 22853689 GO:0006006 glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. IEA Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+. IEA GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity GSVIVG01001128001 22845052 22853689 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+. IEA GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity GSVIVG01001128001 22845052 22853689 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+. IEA GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity GSVIVG01001128001 22845052 22853689 GO:0006006 glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01001128001 22845052 22853689 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01001128001 22845052 22853689 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01001128001 22845052 22853689 GO:0006006 glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01001128001 22845052 22853689 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01001128001 22845052 22853689 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01034341001 17811556 17812772 GSVIVG01017130001 4447810 4460870 GSVIVG01008547001 949852 955503 GSVIVG01006616001 27058647 27059417 GSVIVG01016549001 2891413 2895263 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GSVIVG01016549001 2891413 2895263 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GSVIVG01018367001 10300779 10305359 GSVIVG01020983001 15946855 15952125 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020983001 15946855 15952125 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020983001 15946855 15952125 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020983001 15946855 15952125 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028894001 17739769 17746645 GO:0009306 protein secretion The controlled release of proteins from a cell or group of cells. IEA GO:0005886 plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01028894001 17739769 17746645 GO:0009306 protein secretion The controlled release of proteins from a cell or group of cells. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01028894001 17739769 17746645 GO:0009306 protein secretion The controlled release of proteins from a cell or group of cells. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01028894001 17739769 17746645 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005886 plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01028894001 17739769 17746645 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01028894001 17739769 17746645 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01027187001 17166857 17172986 GSVIVG01003265001 8554583 8556103 GSVIVG01016977001 3123604 3127608 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01036518001 22978035 22994438 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01036518001 22978035 22994438 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01003782001 12644722 12646883 GSVIVG01021921001 5551336 5561864 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01021921001 5551336 5561864 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01021921001 5551336 5561864 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01021921001 5551336 5561864 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01021921001 5551336 5561864 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021921001 5551336 5561864 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021921001 5551336 5561864 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01021921001 5551336 5561864 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01026527001 22259239 22260359 GSVIVG01034289001 14092573 14095403 GSVIVG01000684001 15466461 15470255 GSVIVG01019372001 176330 184360 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009391001 7958765 7961518 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01009391001 7958765 7961518 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01009391001 7958765 7961518 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01009391001 7958765 7961518 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01036123001 20412866 20413066 GSVIVG01002136001 33154621 33158014 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01002136001 33154621 33158014 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01002136001 33154621 33158014 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01002136001 33154621 33158014 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01000339001 11724503 11725430 GSVIVG01005278001 20153172 20155763 GO:0016481 negative regulation of transcription Any cellular process that stops, prevents or reduces the frequency, rate or extent of transcription. IEA Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0010181 FMN binding GSVIVG01005278001 20153172 20155763 GO:0016481 negative regulation of transcription Any cellular process that stops, prevents or reduces the frequency, rate or extent of transcription. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008746001 1677718 1683663 GO:0001522 pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01008746001 1677718 1683663 GO:0009451 RNA modification The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01008746001 1677718 1683663 GO:0001522 pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs. IEA Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. IEA GO:0009982 pseudouridine synthase activity GSVIVG01008746001 1677718 1683663 GO:0009451 RNA modification The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. IEA Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. IEA GO:0009982 pseudouridine synthase activity GSVIVG01020686001 3107167 3110750 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01027190001 17147833 17151204 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01027190001 17147833 17151204 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01027190001 17147833 17151204 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01027190001 17147833 17151204 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01027190001 17147833 17151204 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01027190001 17147833 17151204 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01027190001 17147833 17151204 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01027190001 17147833 17151204 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01027190001 17147833 17151204 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01027190001 17147833 17151204 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01010970001 2517645 2525482 GSVIVG01034724001 8461487 8461618 GSVIVG01024238001 116359 130555 GSVIVG01009200001 6198615 6201341 GSVIVG01032171001 21840879 21852936 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01032171001 21840879 21852936 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01032171001 21840879 21852936 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032171001 21840879 21852936 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032171001 21840879 21852936 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032171001 21840879 21852936 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032171001 21840879 21852936 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01032171001 21840879 21852936 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01035325001 475335 480636 GSVIVG01022397001 19646844 19649245 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals. IEA GO:0008519 ammonium transmembrane transporter activity GSVIVG01022397001 19646844 19649245 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals. IEA GO:0008519 ammonium transmembrane transporter activity GSVIVG01034673001 7477628 7487393 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01034673001 7477628 7487393 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01034673001 7477628 7487393 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01034673001 7477628 7487393 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016796001 1467985 1474688 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01021129001 1705258 1719512 Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. IEA GO:0008171 O-methyltransferase activity GSVIVG01026654001 20663903 20665892 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: 2 H2O2 = O2 + 2 H2O. IEA GO:0004096 catalase activity GSVIVG01026654001 20663903 20665892 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2 H2O2 = O2 + 2 H2O. IEA GO:0004096 catalase activity GSVIVG01026654001 20663903 20665892 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01026654001 20663903 20665892 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01026654001 20663903 20665892 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01026654001 20663903 20665892 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01017600001 1924623 1925889 GSVIVG01026284001 15562423 15563122 GSVIVG01006505001 42490005 42490527 GSVIVG01003310001 8913470 8914619 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with damaged DNA. IEA GO:0003684 damaged DNA binding GSVIVG01003310001 8913470 8914619 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the degradation of double-stranded DNA. It acts progressively in a 3' to 5' direction, releasing 5'-phosphomononucleotides. IEA GO:0008853 exodeoxyribonuclease III activity GSVIVG01033828001 17414416 17415159 GSVIVG01022345001 18768603 18774650 GSVIVG01006462001 26168705 26171272 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01006462001 26168705 26171272 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01006462001 26168705 26171272 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01006462001 26168705 26171272 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01006462001 26168705 26171272 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01006462001 26168705 26171272 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01006462001 26168705 26171272 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01006462001 26168705 26171272 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01002452001 34818536 34821262 GSVIVG01018188001 13418593 13419704 GSVIVG01014267001 2155950 2157323 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01023259001 20482534 20502763 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01023259001 20482534 20502763 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01021734001 10224120 10225715 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021734001 10224120 10225715 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021734001 10224120 10225715 Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01019989001 11948146 11949124 GSVIVG01036643001 19654887 19660055 GSVIVG01036599001 19001952 19003057 Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate. IEA GO:0008146 sulfotransferase activity GSVIVG01004958001 17051216 17057562 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016651 oxidoreductase activity, acting on NADH or NADPH GSVIVG01004958001 17051216 17057562 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds. IEA GO:0048038 quinone binding GSVIVG01004958001 17051216 17057562 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01007474001 32160506 32161888 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: 3-alpha(S)-strictosidine = tryptamine + secologanin. IEA GO:0016844 strictosidine synthase activity GSVIVG01036476001 22533518 22546397 GSVIVG01020708001 2930927 2932974 GSVIVG01021980001 4739890 4745539 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01021980001 4739890 4745539 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01030416001 5408688 5410560 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01009498001 8871576 8873821 GO:0009765 photosynthesis, light harvesting Absorption and transfer of the energy absorbed from light photons between photosystem reaction centers. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01022336001 18583647 18584976 GSVIVG01035436001 1251913 1252699 GSVIVG01037125001 28865684 28886369 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01028432001 7467720 7475135 The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01019706001 2582738 2584192 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01026645001 20782110 20782409 GSVIVG01022269001 18043660 18047601 GSVIVG01008643001 181361 183535 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA Catalysis of the reaction: S-adenosyl-L-methionine + magnesium protoporphyrin = S-adenosyl-L-homocysteine + magnesium protoporphyrin monomethyl ester. IEA GO:0046406 magnesium protoporphyrin IX methyltransferase activity GSVIVG01008643001 181361 183535 GO:0015995 chlorophyll biosynthetic process The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors. IEA Catalysis of the reaction: S-adenosyl-L-methionine + magnesium protoporphyrin = S-adenosyl-L-homocysteine + magnesium protoporphyrin monomethyl ester. IEA GO:0046406 magnesium protoporphyrin IX methyltransferase activity GSVIVG01020215001 8958843 8962074 GO:0005992 trehalose biosynthetic process The chemical reactions and pathways resulting in the formation of trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003613001 11260830 11269998 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005945 6-phosphofructokinase complex A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known. IEA Catalysis of the reaction: ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate. IEA GO:0003872 6-phosphofructokinase activity GSVIVG01003613001 11260830 11269998 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005945 6-phosphofructokinase complex A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007552001 12251718 12257309 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019521001 1309941 1314227 GSVIVG01024023001 1684208 1690440 GSVIVG01024708001 7583498 7598852 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030130 clathrin coat of trans-Golgi network vesicle A clathrin coat found on a vesicle of the trans-Golgi network. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01024708001 7583498 7598852 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030132 clathrin coat of coated pit The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01024708001 7583498 7598852 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030130 clathrin coat of trans-Golgi network vesicle A clathrin coat found on a vesicle of the trans-Golgi network. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01024708001 7583498 7598852 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030132 clathrin coat of coated pit The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01024708001 7583498 7598852 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030130 clathrin coat of trans-Golgi network vesicle A clathrin coat found on a vesicle of the trans-Golgi network. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024708001 7583498 7598852 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030132 clathrin coat of coated pit The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024708001 7583498 7598852 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030130 clathrin coat of trans-Golgi network vesicle A clathrin coat found on a vesicle of the trans-Golgi network. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024708001 7583498 7598852 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030132 clathrin coat of coated pit The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024708001 7583498 7598852 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030130 clathrin coat of trans-Golgi network vesicle A clathrin coat found on a vesicle of the trans-Golgi network. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01024708001 7583498 7598852 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030132 clathrin coat of coated pit The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01024708001 7583498 7598852 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030130 clathrin coat of trans-Golgi network vesicle A clathrin coat found on a vesicle of the trans-Golgi network. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01024708001 7583498 7598852 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030132 clathrin coat of coated pit The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035703001 3465417 3465608 GSVIVG01018179001 13508099 13513451 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013943001 7292908 7295496 GSVIVG01004919001 4801244 4803138 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01004919001 4801244 4803138 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01004919001 4801244 4803138 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01004919001 4801244 4803138 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01004919001 4801244 4803138 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. IEA GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GSVIVG01004919001 4801244 4803138 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. IEA GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GSVIVG01013666001 2184680 2256697 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01013666001 2184680 2256697 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001457001 21139037 21159628 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01001457001 21139037 21159628 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01001457001 21139037 21159628 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001457001 21139037 21159628 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033481001 20357119 20358771 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01033481001 20357119 20358771 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01033481001 20357119 20358771 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01033481001 20357119 20358771 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01033481001 20357119 20358771 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01033481001 20357119 20358771 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01033481001 20357119 20358771 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01033481001 20357119 20358771 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01033481001 20357119 20358771 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01033481001 20357119 20358771 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01033481001 20357119 20358771 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01033481001 20357119 20358771 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01033481001 20357119 20358771 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01033481001 20357119 20358771 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01033481001 20357119 20358771 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01033481001 20357119 20358771 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01033481001 20357119 20358771 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01033481001 20357119 20358771 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01033481001 20357119 20358771 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01033481001 20357119 20358771 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01030341001 8510657 8513677 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018316001 11203909 11209058 GSVIVG01034022001 15777690 15783016 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01034022001 15777690 15783016 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01034022001 15777690 15783016 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01034022001 15777690 15783016 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01034022001 15777690 15783016 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01034022001 15777690 15783016 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01034022001 15777690 15783016 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01034022001 15777690 15783016 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01034022001 15777690 15783016 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01034022001 15777690 15783016 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01034022001 15777690 15783016 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01034022001 15777690 15783016 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01034022001 15777690 15783016 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01034022001 15777690 15783016 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01034022001 15777690 15783016 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01034022001 15777690 15783016 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01034022001 15777690 15783016 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01034022001 15777690 15783016 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01034022001 15777690 15783016 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01034022001 15777690 15783016 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01034022001 15777690 15783016 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01034022001 15777690 15783016 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01034022001 15777690 15783016 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01034022001 15777690 15783016 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024721001 7464879 7465666 GSVIVG01003188001 7714106 7715395 GSVIVG01007626001 11122705 11124249 GSVIVG01002959001 37415626 37418257 GSVIVG01003209001 7923176 7927815 GSVIVG01009276001 6893297 6896731 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009276001 6893297 6896731 GO:0009081 branched chain family amino acid metabolic process The chemical reactions and pathways involving amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009276001 6893297 6896731 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: a branched-chain amino acid + 2-oxoglutarate = L-glutamate + a 2-oxocarboxylate derived from the branched-chain amino acid. Includes catalysis of the reaction: L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate and anaologous reactions involving L-isoleucine and L-valine. IEA GO:0004084 branched-chain-amino-acid transaminase activity GSVIVG01009276001 6893297 6896731 GO:0009081 branched chain family amino acid metabolic process The chemical reactions and pathways involving amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. IEA Catalysis of the reaction: a branched-chain amino acid + 2-oxoglutarate = L-glutamate + a 2-oxocarboxylate derived from the branched-chain amino acid. Includes catalysis of the reaction: L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate and anaologous reactions involving L-isoleucine and L-valine. IEA GO:0004084 branched-chain-amino-acid transaminase activity GSVIVG01003080001 8440840 8464816 GSVIVG01034264001 13674579 13675426 GSVIVG01006114001 41751994 41754446 GSVIVG01002055001 32494135 32499676 Catalysis of the reaction: ATP + thymidine = ADP + thymidine 5'-phosphate. IEA GO:0004797 thymidine kinase activity GSVIVG01002055001 32494135 32499676 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001918001 7193370 7208618 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01001918001 7193370 7208618 Catalysis of the two-stage endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides with 2',3'-cyclic phosphate intermediates. IEA GO:0033897 ribonuclease T2 activity GSVIVG01019143001 16253357 16258888 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01010198001 17248219 17248647 GSVIVG01036854001 18746619 18751691 GSVIVG01031388001 19216516 19217622 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01031388001 19216516 19217622 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01031663001 19783563 19785854 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01008402001 2457851 2459785 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01027802001 7925222 7933404 GSVIVG01015847001 18284554 18284859 GSVIVG01032161001 21985280 21986521 GSVIVG01004649001 39412884 39414136 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01004649001 39412884 39414136 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01023451001 11674479 11680993 GSVIVG01034516001 20041688 20046952 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the removal of a phosphate group from phosphorylated myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol. IEA GO:0004437 inositol or phosphatidylinositol phosphatase activity GSVIVG01034516001 20041688 20046952 GO:0016051 carbohydrate biosynthetic process The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the removal of a phosphate group from phosphorylated myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol. IEA GO:0004437 inositol or phosphatidylinositol phosphatase activity GSVIVG01034516001 20041688 20046952 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01034516001 20041688 20046952 GO:0016051 carbohydrate biosynthetic process The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01034516001 20041688 20046952 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate. IEA GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity GSVIVG01034516001 20041688 20046952 GO:0016051 carbohydrate biosynthetic process The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate. IEA GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity GSVIVG01034516001 20041688 20046952 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3. IEA GO:0042578 phosphoric ester hydrolase activity GSVIVG01034516001 20041688 20046952 GO:0016051 carbohydrate biosynthetic process The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3. IEA GO:0042578 phosphoric ester hydrolase activity GSVIVG01029084001 12189929 12193060 GSVIVG01032071001 22993920 22997214 GSVIVG01027766001 7500049 7507755 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01000258001 20614997 20632498 GSVIVG01033027001 25182954 25188323 GSVIVG01009696001 10552665 10554549 GO:0046080 dUTP metabolic process The chemical reactions and pathways involving dUTP, deoxyuridine (5'-)triphosphate. IEA Catalysis of the reaction: dUTP + H2O = dUMP + diphosphate. IEA GO:0004170 dUTP diphosphatase activity GSVIVG01009696001 10552665 10554549 GO:0046080 dUTP metabolic process The chemical reactions and pathways involving dUTP, deoxyuridine (5'-)triphosphate. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01025875001 27641232 27643249 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01005309001 20497413 20500299 GSVIVG01017653001 2399529 2403126 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01017653001 2399529 2403126 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01017653001 2399529 2403126 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01017653001 2399529 2403126 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01017653001 2399529 2403126 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017653001 2399529 2403126 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017653001 2399529 2403126 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017653001 2399529 2403126 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01021697001 9738147 9742616 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026457001 23260406 23277500 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01026457001 23260406 23277500 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01026457001 23260406 23277500 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01026457001 23260406 23277500 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01026457001 23260406 23277500 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01026457001 23260406 23277500 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01001471001 21358560 21371066 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001471001 21358560 21371066 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020587001 3990316 3990488 GSVIVG01024509001 9431191 9451656 GSVIVG01020696001 3050263 3051361 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004197 cysteine-type endopeptidase activity GSVIVG01020696001 3050263 3051361 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01026798001 7435535 7436055 GSVIVG01019616001 1971916 1976531 GSVIVG01029314001 16961991 17012662 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m). IEA GO:0003910 DNA ligase (ATP) activity GSVIVG01029314001 16961991 17012662 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m). IEA GO:0003910 DNA ligase (ATP) activity GSVIVG01029314001 16961991 17012662 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m). IEA GO:0003910 DNA ligase (ATP) activity GSVIVG01029314001 16961991 17012662 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029314001 16961991 17012662 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029314001 16961991 17012662 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030533001 6532268 6544395 GSVIVG01021544001 6867305 6869519 GSVIVG01036267001 7769572 7791596 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01036267001 7769572 7791596 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016459 myosin complex A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01036267001 7769572 7791596 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate. IEA GO:0003774 motor activity GSVIVG01036267001 7769572 7791596 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016459 myosin complex A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. IEA Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate. IEA GO:0003774 motor activity GSVIVG01036267001 7769572 7791596 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01036267001 7769572 7791596 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016459 myosin complex A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01036267001 7769572 7791596 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036267001 7769572 7791596 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016459 myosin complex A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036267001 7769572 7791596 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036267001 7769572 7791596 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016459 myosin complex A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036267001 7769572 7791596 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01036267001 7769572 7791596 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016459 myosin complex A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01036267001 7769572 7791596 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits. IEA GO:0051015 actin filament binding GSVIVG01036267001 7769572 7791596 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016459 myosin complex A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. IEA Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits. IEA GO:0051015 actin filament binding GSVIVG01038015001 12608952 12612822 GSVIVG01027936001 9759208 9759919 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA Catalysis of the transfer of the amide nitrogen of glutamine to a variety of substrates. GATases catalyze two separate reactions at two active sites, which are located either on a single polypeptide chain or on different subunits. In the glutaminase reaction, glutamine is hydrolyzed to glutamate and ammonia, which is added to an acceptor substrate in the synthase reaction. IEA GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor GSVIVG01027936001 9759208 9759919 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA Catalysis of the transfer of the amide nitrogen of glutamine to a variety of substrates. GATases catalyze two separate reactions at two active sites, which are located either on a single polypeptide chain or on different subunits. In the glutaminase reaction, glutamine is hydrolyzed to glutamate and ammonia, which is added to an acceptor substrate in the synthase reaction. IEA GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor GSVIVG01026463001 23141979 23143556 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017222001 5602946 5610273 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01017222001 5602946 5610273 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017222001 5602946 5610273 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01017222001 5602946 5610273 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01003361001 9354305 9355134 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01010976001 2494341 2496810 GSVIVG01014171001 1061570 1067005 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01014274001 2237270 2251390 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01014274001 2237270 2251390 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014274001 2237270 2251390 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014274001 2237270 2251390 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01014274001 2237270 2251390 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01011085001 1720128 1737241 GO:0009228 thiamin biosynthetic process The chemical reactions and pathways resulting in the formation of thiamin (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01011085001 1720128 1737241 GO:0009228 thiamin biosynthetic process The chemical reactions and pathways resulting in the formation of thiamin (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: 2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-4-methyl-5-(2-phosphonooxyethyl)-thiazole = diphosphate + thiamin monophosphate. IEA GO:0004789 thiamin-phosphate diphosphorylase activity GSVIVG01011085001 1720128 1737241 GO:0009228 thiamin biosynthetic process The chemical reactions and pathways resulting in the formation of thiamin (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01021771001 10897871 10903308 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021771001 10897871 10903308 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021771001 10897871 10903308 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021771001 10897871 10903308 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01021771001 10897871 10903308 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01021771001 10897871 10903308 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01021771001 10897871 10903308 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01021771001 10897871 10903308 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01021771001 10897871 10903308 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01021771001 10897871 10903308 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021771001 10897871 10903308 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021771001 10897871 10903308 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031929001 5469494 5470726 GSVIVG01018343001 10761469 10762811 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018343001 10761469 10762811 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01026377001 15300633 15309621 GSVIVG01004907001 4713635 4718456 GSVIVG01019500001 1137554 1144610 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01019500001 1137554 1144610 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01019500001 1137554 1144610 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01019500001 1137554 1144610 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01019500001 1137554 1144610 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01019500001 1137554 1144610 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01019500001 1137554 1144610 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01019500001 1137554 1144610 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01019500001 1137554 1144610 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01019500001 1137554 1144610 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019500001 1137554 1144610 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019500001 1137554 1144610 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019500001 1137554 1144610 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019500001 1137554 1144610 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019500001 1137554 1144610 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019500001 1137554 1144610 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019500001 1137554 1144610 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019500001 1137554 1144610 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01010772001 22455587 22457965 GSVIVG01008989001 4076661 4078865 GSVIVG01018477001 14549183 14550431 GSVIVG01019548001 1532067 1535757 GSVIVG01028948001 17168325 17169388 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01028948001 17168325 17169388 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01028948001 17168325 17169388 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01028948001 17168325 17169388 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01009647001 10176155 10185052 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01009647001 10176155 10185052 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01009647001 10176155 10185052 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01009647001 10176155 10185052 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01010210001 17554522 17575405 GSVIVG01007754001 9558482 9562161 Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor. IEA GO:0003950 NAD+ ADP-ribosyltransferase activity GSVIVG01020084001 10547654 10551385 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01014066001 48207 58620 GO:0008299 isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. IEA GO:0009842 cyanelle A plastid that contains unstacked, phycobilisome-bearing thylakoid membranes and is surrounded by a peptidoglycan layer as well as a double membrane. Cyanelles are characteristic of algae in the class Glaucophyta, and may represent an ancestral form of plastid. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01014066001 48207 58620 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009842 cyanelle A plastid that contains unstacked, phycobilisome-bearing thylakoid membranes and is surrounded by a peptidoglycan layer as well as a double membrane. Cyanelles are characteristic of algae in the class Glaucophyta, and may represent an ancestral form of plastid. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01014066001 48207 58620 GO:0008299 isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. IEA GO:0009842 cyanelle A plastid that contains unstacked, phycobilisome-bearing thylakoid membranes and is surrounded by a peptidoglycan layer as well as a double membrane. Cyanelles are characteristic of algae in the class Glaucophyta, and may represent an ancestral form of plastid. IEA Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor). IEA GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups GSVIVG01014066001 48207 58620 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009842 cyanelle A plastid that contains unstacked, phycobilisome-bearing thylakoid membranes and is surrounded by a peptidoglycan layer as well as a double membrane. Cyanelles are characteristic of algae in the class Glaucophyta, and may represent an ancestral form of plastid. IEA Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor). IEA GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups GSVIVG01018729001 20350179 20354875 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01018729001 20350179 20354875 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01018729001 20350179 20354875 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01018729001 20350179 20354875 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01018729001 20350179 20354875 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01018729001 20350179 20354875 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01018729001 20350179 20354875 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01018729001 20350179 20354875 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01018729001 20350179 20354875 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01018729001 20350179 20354875 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01018729001 20350179 20354875 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01018729001 20350179 20354875 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01018729001 20350179 20354875 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01018729001 20350179 20354875 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01018729001 20350179 20354875 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01018729001 20350179 20354875 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01018729001 20350179 20354875 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01018729001 20350179 20354875 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01018729001 20350179 20354875 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01018729001 20350179 20354875 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01018729001 20350179 20354875 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018729001 20350179 20354875 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018729001 20350179 20354875 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018729001 20350179 20354875 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018729001 20350179 20354875 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018729001 20350179 20354875 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018729001 20350179 20354875 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018729001 20350179 20354875 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018729001 20350179 20354875 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018729001 20350179 20354875 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018729001 20350179 20354875 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01018729001 20350179 20354875 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01018729001 20350179 20354875 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01018729001 20350179 20354875 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01018729001 20350179 20354875 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01018729001 20350179 20354875 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01018729001 20350179 20354875 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01018729001 20350179 20354875 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01018729001 20350179 20354875 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01018729001 20350179 20354875 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01037417001 14131231 14133129 GSVIVG01004564001 39060267 39061560 GSVIVG01008792001 2113195 2127909 GSVIVG01003954001 14017915 14021323 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. IEA GO:0004618 phosphoglycerate kinase activity GSVIVG01003954001 14017915 14021323 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. IEA GO:0004618 phosphoglycerate kinase activity GSVIVG01003954001 14017915 14021323 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01003954001 14017915 14021323 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01034218001 12952152 12952451 GSVIVG01012770001 23531601 23537679 GSVIVG01033692001 18605775 18623470 GO:0006542 glutamine biosynthetic process The chemical reactions and pathways resulting in the formation of glutamine, 2-amino-4-carbamoylbutanoic acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033692001 18605775 18623470 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033692001 18605775 18623470 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033692001 18605775 18623470 GO:0006542 glutamine biosynthetic process The chemical reactions and pathways resulting in the formation of glutamine, 2-amino-4-carbamoylbutanoic acid. IEA Catalysis of the reaction: ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine. IEA GO:0004356 glutamate-ammonia ligase activity GSVIVG01033692001 18605775 18623470 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA Catalysis of the reaction: ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine. IEA GO:0004356 glutamate-ammonia ligase activity GSVIVG01033692001 18605775 18623470 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine. IEA GO:0004356 glutamate-ammonia ligase activity GSVIVG01000606001 6602502 6605920 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019305001 1547532 1560351 GO:0006400 tRNA modification The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically. IEA Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N7-methylguanine. IEA GO:0008176 tRNA (guanine-N7-)-methyltransferase activity GSVIVG01021747001 10471902 10480784 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG. IEA GO:0030126 COPI vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01021747001 10471902 10480784 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG. IEA GO:0030126 COPI vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01021747001 10471902 10480784 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG. IEA GO:0030126 COPI vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01038335001 13186670 13192409 GSVIVG01030167001 10896654 10902936 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01030167001 10896654 10902936 GO:0016539 intein-mediated protein splicing The removal of an internal amino acid sequence (an intein) from a protein during protein maturation; the excision of inteins is precise and the N- and C-terminal exteins are joined by a normal peptide bond. Protein splicing involves 4 nucleophilic displacements by the 3 conserved splice junction residues. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01030167001 10896654 10902936 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01030167001 10896654 10902936 GO:0016539 intein-mediated protein splicing The removal of an internal amino acid sequence (an intein) from a protein during protein maturation; the excision of inteins is precise and the N- and C-terminal exteins are joined by a normal peptide bond. Protein splicing involves 4 nucleophilic displacements by the 3 conserved splice junction residues. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01030167001 10896654 10902936 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01030167001 10896654 10902936 GO:0016539 intein-mediated protein splicing The removal of an internal amino acid sequence (an intein) from a protein during protein maturation; the excision of inteins is precise and the N- and C-terminal exteins are joined by a normal peptide bond. Protein splicing involves 4 nucleophilic displacements by the 3 conserved splice junction residues. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01030167001 10896654 10902936 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030167001 10896654 10902936 GO:0016539 intein-mediated protein splicing The removal of an internal amino acid sequence (an intein) from a protein during protein maturation; the excision of inteins is precise and the N- and C-terminal exteins are joined by a normal peptide bond. Protein splicing involves 4 nucleophilic displacements by the 3 conserved splice junction residues. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011353001 28909634 28912866 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: cysteamine + O2 = hypotaurine. IEA GO:0047800 cysteamine dioxygenase activity GSVIVG01018052001 5824109 5839208 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01018052001 5824109 5839208 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01018052001 5824109 5839208 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01018052001 5824109 5839208 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018052001 5824109 5839208 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028898001 17700856 17707425 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028898001 17700856 17707425 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028898001 17700856 17707425 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028898001 17700856 17707425 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028898001 17700856 17707425 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028898001 17700856 17707425 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028898001 17700856 17707425 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01028898001 17700856 17707425 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01028898001 17700856 17707425 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01028898001 17700856 17707425 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01028898001 17700856 17707425 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01028898001 17700856 17707425 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01026495001 22706307 22713079 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01015537001 4652342 4653819 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01015537001 4652342 4653819 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01015537001 4652342 4653819 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01015537001 4652342 4653819 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01016818001 1648475 1651220 GSVIVG01004462001 38671273 38671609 GSVIVG01029737001 13926758 13927781 GSVIVG01020972001 16116095 16119430 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01021625001 8333352 8341424 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01021625001 8333352 8341424 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01021625001 8333352 8341424 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01021625001 8333352 8341424 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01021625001 8333352 8341424 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01021625001 8333352 8341424 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01019671001 2356708 2357477 GSVIVG01010256001 18461884 18463681 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01010256001 18461884 18463681 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01002693001 35840619 35841215 GSVIVG01036003001 7008326 7009119 GSVIVG01012026001 2094462 2096907 GSVIVG01024493001 3324473 3326821 GSVIVG01007730001 9846863 9851923 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Catalysis of the reaction: 4 ATP + 2 phosphorylase b = 4 ADP + phosphorylase a. IEA GO:0004689 phosphorylase kinase activity GSVIVG01007730001 9846863 9851923 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: 4 ATP + 2 phosphorylase b = 4 ADP + phosphorylase a. IEA GO:0004689 phosphorylase kinase activity GSVIVG01007730001 9846863 9851923 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: 4 ATP + 2 phosphorylase b = 4 ADP + phosphorylase a. IEA GO:0004689 phosphorylase kinase activity GSVIVG01007730001 9846863 9851923 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Catalysis of the reaction: 4 ATP + 2 phosphorylase b = 4 ADP + phosphorylase a. IEA GO:0004689 phosphorylase kinase activity GSVIVG01007730001 9846863 9851923 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: 4 ATP + 2 phosphorylase b = 4 ADP + phosphorylase a. IEA GO:0004689 phosphorylase kinase activity GSVIVG01007730001 9846863 9851923 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: 4 ATP + 2 phosphorylase b = 4 ADP + phosphorylase a. IEA GO:0004689 phosphorylase kinase activity GSVIVG01007730001 9846863 9851923 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Catalysis of the reaction: 4 ATP + 2 phosphorylase b = 4 ADP + phosphorylase a. IEA GO:0004689 phosphorylase kinase activity GSVIVG01007730001 9846863 9851923 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: 4 ATP + 2 phosphorylase b = 4 ADP + phosphorylase a. IEA GO:0004689 phosphorylase kinase activity GSVIVG01007730001 9846863 9851923 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: 4 ATP + 2 phosphorylase b = 4 ADP + phosphorylase a. IEA GO:0004689 phosphorylase kinase activity GSVIVG01007730001 9846863 9851923 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01007730001 9846863 9851923 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01007730001 9846863 9851923 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01007730001 9846863 9851923 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01007730001 9846863 9851923 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01007730001 9846863 9851923 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01007730001 9846863 9851923 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01007730001 9846863 9851923 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01007730001 9846863 9851923 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01007730001 9846863 9851923 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. IEA GO:0005516 calmodulin binding GSVIVG01007730001 9846863 9851923 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. IEA GO:0005516 calmodulin binding GSVIVG01007730001 9846863 9851923 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. IEA GO:0005516 calmodulin binding GSVIVG01007730001 9846863 9851923 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. IEA GO:0005516 calmodulin binding GSVIVG01007730001 9846863 9851923 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. IEA GO:0005516 calmodulin binding GSVIVG01007730001 9846863 9851923 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. IEA GO:0005516 calmodulin binding GSVIVG01007730001 9846863 9851923 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. IEA GO:0005516 calmodulin binding GSVIVG01007730001 9846863 9851923 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. IEA GO:0005516 calmodulin binding GSVIVG01007730001 9846863 9851923 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. IEA GO:0005516 calmodulin binding GSVIVG01007730001 9846863 9851923 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007730001 9846863 9851923 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007730001 9846863 9851923 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007730001 9846863 9851923 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007730001 9846863 9851923 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007730001 9846863 9851923 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007730001 9846863 9851923 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007730001 9846863 9851923 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007730001 9846863 9851923 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032300001 14773971 14774159 GSVIVG01013198001 6835341 6855471 GSVIVG01025488001 387188 390226 GSVIVG01008611001 423990 428203 GSVIVG01031065001 21742614 21743642 GSVIVG01017392001 7799652 7801028 GSVIVG01030615001 7187048 7189996 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01030615001 7187048 7189996 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01030615001 7187048 7189996 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01030615001 7187048 7189996 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01030615001 7187048 7189996 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01030615001 7187048 7189996 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01030615001 7187048 7189996 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01030615001 7187048 7189996 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01030615001 7187048 7189996 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01030845001 17494206 17495744 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01010378001 19997292 20000950 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01000327001 11420553 11421187 GSVIVG01033584001 19537604 19540313 GSVIVG01026049001 25314000 25327769 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01026049001 25314000 25327769 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01026049001 25314000 25327769 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01017289001 6407205 6412879 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01035443001 1298297 1304140 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01026525001 22283582 22287943 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01027995001 3068169 3087129 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01027995001 3068169 3087129 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01027995001 3068169 3087129 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01027995001 3068169 3087129 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027995001 3068169 3087129 Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01027995001 3068169 3087129 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01027995001 3068169 3087129 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01029709001 13499800 13500752 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025202001 3356318 3358771 GO:0009405 pathogenesis The set of specific processes that generate the ability of an organism to cause disease in another. IEA GO:0009289 pilus A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter. IEA GSVIVG01006610001 26994246 26999175 GSVIVG01004893001 16484525 16485859 GSVIVG01010500001 21108240 21119819 GSVIVG01033088001 25626058 25641296 GO:0009082 branched chain family amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01033088001 25626058 25641296 GO:0009082 branched chain family amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033088001 25626058 25641296 GO:0009082 branched chain family amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. IEA Catalysis of the reaction: 2 pyruvate = 2-acetolactate + CO2. IEA GO:0003984 acetolactate synthase activity GSVIVG01033088001 25626058 25641296 GO:0009082 branched chain family amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. IEA Interacting selectively and non-covalently with thiamin pyrophosphate, the diphosphoric ester of thiamin. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases. IEA GO:0030976 thiamin pyrophosphate binding GSVIVG01033088001 25626058 25641296 GO:0009082 branched chain family amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01016697001 440378 441443 GSVIVG01019050001 17361964 17370460 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: phosphatidylcholine + a sterol = a sterol ester + 1-acylglycerophosphocholine. IEA GO:0004607 phosphatidylcholine-sterol O-acyltransferase activity GSVIVG01026622001 20951210 20953335 GSVIVG01010737001 21967317 21971056 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01010737001 21967317 21971056 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01010737001 21967317 21971056 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: 2 glutathione + H2O2 = oxidized glutathione + 2 H2O. IEA GO:0004602 glutathione peroxidase activity GSVIVG01010737001 21967317 21971056 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2 glutathione + H2O2 = oxidized glutathione + 2 H2O. IEA GO:0004602 glutathione peroxidase activity GSVIVG01010737001 21967317 21971056 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01010737001 21967317 21971056 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01007908001 7682413 7685594 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01007908001 7682413 7685594 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01023777001 10997161 11004941 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023777001 10997161 11004941 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01023777001 10997161 11004941 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01037159001 28445583 28452592 GO:0006071 glycerol metabolic process The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. IEA Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. IEA GO:0008081 phosphoric diester hydrolase activity GSVIVG01037159001 28445583 28452592 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. IEA GO:0008081 phosphoric diester hydrolase activity GSVIVG01037159001 28445583 28452592 GO:0006071 glycerol metabolic process The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. IEA Catalysis of the reaction: a glycerophosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate. IEA GO:0008889 glycerophosphodiester phosphodiesterase activity GSVIVG01037159001 28445583 28452592 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: a glycerophosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate. IEA GO:0008889 glycerophosphodiester phosphodiesterase activity GSVIVG01036377001 4346627 4387107 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01019131001 16404476 16417806 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01019131001 16404476 16417806 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019131001 16404476 16417806 Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01019131001 16404476 16417806 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01019536001 1423490 1424381 GSVIVG01023763001 10748148 10756512 GSVIVG01031799001 4455953 4467024 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). IEA GO:0003755 peptidyl-prolyl cis-trans isomerase activity GSVIVG01031799001 4455953 4467024 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008613001 406868 413574 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01008613001 406868 413574 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01008613001 406868 413574 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01008613001 406868 413574 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031440001 18553842 18562602 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0008236 serine-type peptidase activity GSVIVG01022296001 18304597 18309144 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01022296001 18304597 18309144 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01022296001 18304597 18309144 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity. IEA GO:0004721 phosphoprotein phosphatase activity GSVIVG01022296001 18304597 18309144 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. IEA GO:0004722 protein serine/threonine phosphatase activity GSVIVG01022296001 18304597 18309144 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01022296001 18304597 18309144 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01031641001 19454352 19457007 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031641001 19454352 19457007 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). IEA GO:0016769 transferase activity, transferring nitrogenous groups GSVIVG01031641001 19454352 19457007 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01008692001 1247946 1248829 GSVIVG01024588001 8601684 8603477 GSVIVG01032282001 14515406 14515579 GSVIVG01028930001 17352540 17355619 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01028930001 17352540 17355619 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01028930001 17352540 17355619 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01028930001 17352540 17355619 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01028930001 17352540 17355619 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01028930001 17352540 17355619 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01000667001 20567845 20568085 GSVIVG01028687001 12122284 12131027 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01028687001 12122284 12131027 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01036318001 3759661 3760295 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01022281001 18154841 18171496 GO:0006397 mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01022281001 18154841 18171496 GO:0006397 mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01022281001 18154841 18171496 GO:0006397 mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01038580001 21738678 21742840 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023228001 20919067 20920387 GO:0006414 translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. IEA GO:0005853 eukaryotic translation elongation factor 1 complex A multisubunit nucleotide exchange complex that binds GTP and aminoacyl-tRNAs, and catalyzes their codon-dependent placement at the A-site of the ribosome. In humans, the complex is composed of four subunits, alpha, beta, delta and gamma. IEA Functions in chain elongation during polypeptide synthesis at the ribosome. IEA GO:0003746 translation elongation factor activity GSVIVG01007718001 9949638 9964293 GSVIVG01010764001 22388484 22392054 GSVIVG01018568001 13239867 13244209 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01019917001 4438966 4440027 GSVIVG01007825001 8671006 8672350 GSVIVG01000764001 517688 519205 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01000764001 517688 519205 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01000764001 517688 519205 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01000764001 517688 519205 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01000764001 517688 519205 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01000764001 517688 519205 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01020596001 3950458 3953627 GSVIVG01032710001 1337967 1342419 GO:0006779 porphyrin biosynthetic process The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group. IEA Catalysis of the reaction: uroporphyrinogen-III = coproporphyrinogen + 4 CO2. IEA GO:0004853 uroporphyrinogen decarboxylase activity GSVIVG01030483001 6084113 6086794 GSVIVG01010638001 15714860 15723002 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01010638001 15714860 15723002 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01016282001 5559123 5571573 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. IEA GO:0016853 isomerase activity GSVIVG01018461001 14744889 14746085 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01018461001 14744889 14746085 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01018461001 14744889 14746085 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01018461001 14744889 14746085 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01005722001 21626525 21630369 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01005722001 21626525 21630369 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01005722001 21626525 21630369 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021622001 8295874 8310552 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01021622001 8295874 8310552 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016602 CCAAT-binding factor complex A heteromeric transcription factor complex that binds to the CCAAT-box upstream of promoters; in Saccharomyces it activates the transcription of genes in response to growth in a nonfermentable carbon source; consists of four known subunits: HAP2, HAP3, HAP4 and HAP5. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01021622001 8295874 8310552 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01021622001 8295874 8310552 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016602 CCAAT-binding factor complex A heteromeric transcription factor complex that binds to the CCAAT-box upstream of promoters; in Saccharomyces it activates the transcription of genes in response to growth in a nonfermentable carbon source; consists of four known subunits: HAP2, HAP3, HAP4 and HAP5. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01024514001 9415972 9416217 GSVIVG01037888001 6699291 6705616 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GSVIVG01009661001 10276323 10286829 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01033542001 19867986 19870549 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033542001 19867986 19870549 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01033542001 19867986 19870549 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01000566001 7007865 7024648 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01000566001 7007865 7024648 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01000566001 7007865 7024648 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01000566001 7007865 7024648 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01031618001 19047737 19052175 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01031618001 19047737 19052175 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01031618001 19047737 19052175 GO:0007160 cell-matrix adhesion The binding of a cell to the extracellular matrix via adhesion molecules. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01031618001 19047737 19052175 GO:0007229 integrin-mediated signaling pathway Any series of molecular signals generated as a consequence of an integrin binding to one of its physiological ligands. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01031618001 19047737 19052175 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01031618001 19047737 19052175 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01031618001 19047737 19052175 GO:0007160 cell-matrix adhesion The binding of a cell to the extracellular matrix via adhesion molecules. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01031618001 19047737 19052175 GO:0007229 integrin-mediated signaling pathway Any series of molecular signals generated as a consequence of an integrin binding to one of its physiological ligands. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01031618001 19047737 19052175 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01031618001 19047737 19052175 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01031618001 19047737 19052175 GO:0007160 cell-matrix adhesion The binding of a cell to the extracellular matrix via adhesion molecules. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01031618001 19047737 19052175 GO:0007229 integrin-mediated signaling pathway Any series of molecular signals generated as a consequence of an integrin binding to one of its physiological ligands. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01031618001 19047737 19052175 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01031618001 19047737 19052175 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01031618001 19047737 19052175 GO:0007160 cell-matrix adhesion The binding of a cell to the extracellular matrix via adhesion molecules. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01031618001 19047737 19052175 GO:0007229 integrin-mediated signaling pathway Any series of molecular signals generated as a consequence of an integrin binding to one of its physiological ligands. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01031618001 19047737 19052175 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01031618001 19047737 19052175 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01031618001 19047737 19052175 GO:0007160 cell-matrix adhesion The binding of a cell to the extracellular matrix via adhesion molecules. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01031618001 19047737 19052175 GO:0007229 integrin-mediated signaling pathway Any series of molecular signals generated as a consequence of an integrin binding to one of its physiological ligands. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01031618001 19047737 19052175 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031618001 19047737 19052175 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031618001 19047737 19052175 GO:0007160 cell-matrix adhesion The binding of a cell to the extracellular matrix via adhesion molecules. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031618001 19047737 19052175 GO:0007229 integrin-mediated signaling pathway Any series of molecular signals generated as a consequence of an integrin binding to one of its physiological ligands. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031618001 19047737 19052175 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031618001 19047737 19052175 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031618001 19047737 19052175 GO:0007160 cell-matrix adhesion The binding of a cell to the extracellular matrix via adhesion molecules. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031618001 19047737 19052175 GO:0007229 integrin-mediated signaling pathway Any series of molecular signals generated as a consequence of an integrin binding to one of its physiological ligands. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031618001 19047737 19052175 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031618001 19047737 19052175 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031618001 19047737 19052175 GO:0007160 cell-matrix adhesion The binding of a cell to the extracellular matrix via adhesion molecules. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031618001 19047737 19052175 GO:0007229 integrin-mediated signaling pathway Any series of molecular signals generated as a consequence of an integrin binding to one of its physiological ligands. IEA GO:0008305 integrin complex A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031177001 1474700 1477352 GSVIVG01030015001 8939703 8942536 GSVIVG01035529001 2059973 2064897 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01035529001 2059973 2064897 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01035529001 2059973 2064897 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035529001 2059973 2064897 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032663001 1685142 1712259 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01032663001 1685142 1712259 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01032663001 1685142 1712259 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032663001 1685142 1712259 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021168001 2121041 2127980 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01016116001 19304719 19305945 GSVIVG01024954001 5702435 5711356 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01024177001 579357 583313 GSVIVG01006577001 26588253 26591954 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01017364001 7393594 7403004 The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01022745001 15980876 15983548 GO:0001539 ciliary or flagellar motility Cell motility due to movement of cilia or flagella. IEA GO:0009428 bacterial-type flagellum basal body, distal rod, P ring One of the rings of the flagellar basal body; anchors the basal body to the peptidoglycan layer. Examples of this component are found in bacteria. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01022745001 15980876 15983548 GO:0001539 ciliary or flagellar motility Cell motility due to movement of cilia or flagella. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01022745001 15980876 15983548 GO:0001539 ciliary or flagellar motility Cell motility due to movement of cilia or flagella. IEA GO:0009428 bacterial-type flagellum basal body, distal rod, P ring One of the rings of the flagellar basal body; anchors the basal body to the peptidoglycan layer. Examples of this component are found in bacteria. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01022745001 15980876 15983548 GO:0001539 ciliary or flagellar motility Cell motility due to movement of cilia or flagella. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01034018001 15801449 15808663 GSVIVG01012360001 1294338 1294469 GSVIVG01012390001 355518 359648 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012390001 355518 359648 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01002262001 33764235 33767104 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01002262001 33764235 33767104 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01025806001 11653179 11663169 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01025806001 11653179 11663169 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01025806001 11653179 11663169 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01025806001 11653179 11663169 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01025806001 11653179 11663169 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Catalysis of the reaction: 4 ATP + 2 phosphorylase b = 4 ADP + phosphorylase a. IEA GO:0004689 phosphorylase kinase activity GSVIVG01025806001 11653179 11663169 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Catalysis of the reaction: 4 ATP + 2 phosphorylase b = 4 ADP + phosphorylase a. IEA GO:0004689 phosphorylase kinase activity GSVIVG01025806001 11653179 11663169 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01025806001 11653179 11663169 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01025806001 11653179 11663169 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. IEA GO:0005516 calmodulin binding GSVIVG01025806001 11653179 11663169 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. IEA GO:0005516 calmodulin binding GSVIVG01025806001 11653179 11663169 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025806001 11653179 11663169 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017546001 10343521 10355108 GSVIVG01026069001 24994025 24994306 GSVIVG01037148001 28610015 28612509 GSVIVG01025341001 1790969 1850500 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01025341001 1790969 1850500 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: linoleate + O2 = (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate. IEA GO:0016165 lipoxygenase activity GSVIVG01025341001 1790969 1850500 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor. IEA GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen GSVIVG01025341001 1790969 1850500 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01028555001 9671071 9673384 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01004106001 14865328 14868986 GSVIVG01035066001 1271444 1272482 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GSVIVG01035066001 1271444 1272482 GO:0009607 response to biotic stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism. IEA GSVIVG01018434001 15214072 15221974 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018434001 15214072 15221974 GO:0008299 isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018434001 15214072 15221974 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA. IEA GO:0004421 hydroxymethylglutaryl-CoA synthase activity GSVIVG01018434001 15214072 15221974 GO:0008299 isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. IEA Catalysis of the reaction: acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA. IEA GO:0004421 hydroxymethylglutaryl-CoA synthase activity GSVIVG01023154001 21859609 21872847 GSVIVG01023545001 9886212 9896657 GSVIVG01011385001 29226978 29244552 GSVIVG01025891001 27437276 27443136 GSVIVG01025342001 1774659 1781744 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01025342001 1774659 1781744 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: linoleate + O2 = (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate. IEA GO:0016165 lipoxygenase activity GSVIVG01025342001 1774659 1781744 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor. IEA GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen GSVIVG01025342001 1774659 1781744 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01013074001 8734266 8734868 GSVIVG01033982001 16121573 16121974 GSVIVG01005079001 14336610 14338903 GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + H+(out) = sugar(in) + H+(in). IEA GO:0005351 sugar:hydrogen symporter activity GSVIVG01003429001 14903435 14935694 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01001193001 944892 950225 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01001193001 944892 950225 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01001193001 944892 950225 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01001193001 944892 950225 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021653001 8790411 8800569 GO:0032312 regulation of ARF GTPase activity Any process that modulates the activity of the GTPase ARF. IEA Increases the rate of GTP hydrolysis by the GTPase ARF. IEA GO:0008060 ARF GTPase activator activity GSVIVG01021653001 8790411 8800569 GO:0032312 regulation of ARF GTPase activity Any process that modulates the activity of the GTPase ARF. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01017097001 4138680 4140725 GSVIVG01027902001 9207717 9208629 GSVIVG01026123001 24275038 24277541 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01026123001 24275038 24277541 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01026123001 24275038 24277541 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01026123001 24275038 24277541 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01026123001 24275038 24277541 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038283001 24968752 24969352 GSVIVG01028793001 18748451 18748819 GSVIVG01000158001 15737603 15740223 GSVIVG01000851001 2929576 2931838 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01000851001 2929576 2931838 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01000851001 2929576 2931838 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01000851001 2929576 2931838 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01000851001 2929576 2931838 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01000851001 2929576 2931838 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01000851001 2929576 2931838 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01000851001 2929576 2931838 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01022548001 4702410 4706076 GSVIVG01011020001 2157230 2169012 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01011020001 2157230 2169012 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019000001 17933767 17936828 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01024026001 1670610 1674073 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01024026001 1670610 1674073 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01024026001 1670610 1674073 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01024026001 1670610 1674073 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037717001 7223203 7225703 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01037717001 7223203 7225703 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01017057001 3835169 3837600 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007610001 11284888 11287081 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01007610001 11284888 11287081 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01007610001 11284888 11287081 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01007610001 11284888 11287081 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01029451001 22734039 22735527 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01012858001 6274252 6276491 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01029566001 21482997 21483422 GSVIVG01028494001 8411676 8423154 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01006754001 28099849 28101856 GSVIVG01004264001 37820843 37821025 GSVIVG01016328001 5001203 5002266 GSVIVG01022344001 18748949 18768220 GSVIVG01037936001 11138600 11140093 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01037936001 11138600 11140093 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01037936001 11138600 11140093 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01037936001 11138600 11140093 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01030258001 9796056 9798907 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01030258001 9796056 9798907 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01030258001 9796056 9798907 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01009787001 11261403 11261579 GSVIVG01020636001 3597741 3614984 Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. IEA GO:0008171 O-methyltransferase activity GSVIVG01010296001 19178779 19180228 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01020578001 4108297 4110237 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01005334001 39697885 39699350 GSVIVG01019823001 3644701 3649060 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01019823001 3644701 3649060 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01002660001 35724667 35738772 GSVIVG01006772001 28313887 28315289 GSVIVG01007480001 32183377 32184049 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007480001 32183377 32184049 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007480001 32183377 32184049 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01007480001 32183377 32184049 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01007480001 32183377 32184049 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01007480001 32183377 32184049 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01005853001 22248659 22265318 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01027049001 18367259 18368556 GSVIVG01035717001 3613654 3623291 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035717001 3613654 3623291 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). IEA GO:0016769 transferase activity, transferring nitrogenous groups GSVIVG01035717001 3613654 3623291 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + methylthioadenosine. IEA GO:0016847 1-aminocyclopropane-1-carboxylate synthase activity GSVIVG01035717001 3613654 3623291 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01035328001 503963 528680 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01035328001 503963 528680 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01005521001 40558324 40559266 GSVIVG01001908001 7090883 7091876 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01001908001 7090883 7091876 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01003441001 9955991 9957144 GSVIVG01009556001 9356043 9381105 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01008033001 6456981 6469336 GSVIVG01011974001 2488784 2491709 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01003533001 169338 169684 GSVIVG01038010001 12495108 12499398 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01038010001 12495108 12499398 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035620001 2754158 2755987 GSVIVG01022927001 17887919 17888362 GSVIVG01030333001 8753833 8754318 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01001194001 931773 943464 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001194001 931773 943464 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001194001 931773 943464 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA Catalysis of a reaction that results in the formation of carbamoyl phosphate. IEA GO:0004086 carbamoyl-phosphate synthase activity GSVIVG01001194001 931773 943464 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a reaction that results in the formation of carbamoyl phosphate. IEA GO:0004086 carbamoyl-phosphate synthase activity GSVIVG01001194001 931773 943464 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001194001 931773 943464 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001194001 931773 943464 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA Interacting selectively and non-covalently with biotin (cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid), the (+) enantiomer of which is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions. IEA GO:0009374 biotin binding GSVIVG01001194001 931773 943464 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with biotin (cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid), the (+) enantiomer of which is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions. IEA GO:0009374 biotin binding GSVIVG01001194001 931773 943464 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01001194001 931773 943464 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01018139001 6967402 6967893 GO:0009611 response to wounding A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism. IEA Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme. IEA GO:0004867 serine-type endopeptidase inhibitor activity GSVIVG01003391001 9833714 9835503 GSVIVG01032295001 14646165 14648005 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nucleotidyl group to a reactant. IEA GO:0016779 nucleotidyltransferase activity GSVIVG01014325001 2667892 2670271 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01014325001 2667892 2670271 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01002674001 35811850 35812393 GSVIVG01034325001 18115991 18117362 GSVIVG01026257001 15017209 15022549 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01026257001 15017209 15022549 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01010817001 22974128 22989011 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01021280001 3340198 3390494 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01021280001 3340198 3390494 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01021280001 3340198 3390494 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01021280001 3340198 3390494 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01021280001 3340198 3390494 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038343001 13282706 13288251 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01038343001 13282706 13288251 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01038343001 13282706 13288251 GO:0007596 blood coagulation The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01038343001 13282706 13288251 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01038343001 13282706 13288251 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01038343001 13282706 13288251 GO:0007596 blood coagulation The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01038343001 13282706 13288251 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01038343001 13282706 13288251 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01038343001 13282706 13288251 GO:0007596 blood coagulation The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01038343001 13282706 13288251 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01038343001 13282706 13288251 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01038343001 13282706 13288251 GO:0007596 blood coagulation The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01038343001 13282706 13288251 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038343001 13282706 13288251 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038343001 13282706 13288251 GO:0007596 blood coagulation The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038343001 13282706 13288251 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01038343001 13282706 13288251 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01038343001 13282706 13288251 GO:0007596 blood coagulation The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01029870001 801437 862302 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01029870001 801437 862302 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01029870001 801437 862302 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01029870001 801437 862302 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029870001 801437 862302 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003721001 7391538 7401203 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01003721001 7391538 7401203 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01003721001 7391538 7401203 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01003721001 7391538 7401203 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01003721001 7391538 7401203 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01003721001 7391538 7401203 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01037977001 11978973 11979227 GSVIVG01033798001 17734959 17736499 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01009778001 11188322 11195618 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01009778001 11188322 11195618 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01009778001 11188322 11195618 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01020527001 4833731 4837306 GSVIVG01002722001 36085377 36091532 GSVIVG01023492001 11047441 11048292 GSVIVG01024423001 2409120 2421976 GSVIVG01013388001 780748 784482 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01013388001 780748 784482 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01013388001 780748 784482 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01013388001 780748 784482 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01013388001 780748 784482 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01013388001 780748 784482 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01033895001 16923392 16942864 GSVIVG01007185001 30699129 30700740 GSVIVG01028975001 16971499 16973459 GSVIVG01015363001 3008277 3017867 GSVIVG01016771001 1204878 1220083 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01016771001 1204878 1220083 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01019361001 370963 405661 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005887 integral to plasma membrane Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01019361001 370963 405661 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01019361001 370963 405661 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01019361001 370963 405661 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005887 integral to plasma membrane Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01019361001 370963 405661 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01019361001 370963 405661 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01019361001 370963 405661 GO:0006836 neurotransmitter transport The directed movement of a neurotransmitter into, out of, within or between cells by means of some external agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. IEA GO:0005887 integral to plasma membrane Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01019361001 370963 405661 GO:0006836 neurotransmitter transport The directed movement of a neurotransmitter into, out of, within or between cells by means of some external agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01019361001 370963 405661 GO:0006836 neurotransmitter transport The directed movement of a neurotransmitter into, out of, within or between cells by means of some external agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01019361001 370963 405661 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0005887 integral to plasma membrane Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01019361001 370963 405661 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01019361001 370963 405661 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01019361001 370963 405661 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005887 integral to plasma membrane Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01019361001 370963 405661 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01019361001 370963 405661 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01019361001 370963 405661 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005887 integral to plasma membrane Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01019361001 370963 405661 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01019361001 370963 405661 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01019361001 370963 405661 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005887 integral to plasma membrane Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in). IEA GO:0005328 neurotransmitter:sodium symporter activity GSVIVG01019361001 370963 405661 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in). IEA GO:0005328 neurotransmitter:sodium symporter activity GSVIVG01019361001 370963 405661 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in). IEA GO:0005328 neurotransmitter:sodium symporter activity GSVIVG01019361001 370963 405661 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005887 integral to plasma membrane Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in). IEA GO:0005328 neurotransmitter:sodium symporter activity GSVIVG01019361001 370963 405661 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in). IEA GO:0005328 neurotransmitter:sodium symporter activity GSVIVG01019361001 370963 405661 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in). IEA GO:0005328 neurotransmitter:sodium symporter activity GSVIVG01019361001 370963 405661 GO:0006836 neurotransmitter transport The directed movement of a neurotransmitter into, out of, within or between cells by means of some external agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. IEA GO:0005887 integral to plasma membrane Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in). IEA GO:0005328 neurotransmitter:sodium symporter activity GSVIVG01019361001 370963 405661 GO:0006836 neurotransmitter transport The directed movement of a neurotransmitter into, out of, within or between cells by means of some external agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in). IEA GO:0005328 neurotransmitter:sodium symporter activity GSVIVG01019361001 370963 405661 GO:0006836 neurotransmitter transport The directed movement of a neurotransmitter into, out of, within or between cells by means of some external agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in). IEA GO:0005328 neurotransmitter:sodium symporter activity GSVIVG01019361001 370963 405661 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0005887 integral to plasma membrane Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in). IEA GO:0005328 neurotransmitter:sodium symporter activity GSVIVG01019361001 370963 405661 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in). IEA GO:0005328 neurotransmitter:sodium symporter activity GSVIVG01019361001 370963 405661 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in). IEA GO:0005328 neurotransmitter:sodium symporter activity GSVIVG01019361001 370963 405661 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005887 integral to plasma membrane Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in). IEA GO:0005328 neurotransmitter:sodium symporter activity GSVIVG01019361001 370963 405661 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in). IEA GO:0005328 neurotransmitter:sodium symporter activity GSVIVG01019361001 370963 405661 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in). IEA GO:0005328 neurotransmitter:sodium symporter activity GSVIVG01019361001 370963 405661 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005887 integral to plasma membrane Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in). IEA GO:0005328 neurotransmitter:sodium symporter activity GSVIVG01019361001 370963 405661 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in). IEA GO:0005328 neurotransmitter:sodium symporter activity GSVIVG01019361001 370963 405661 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in). IEA GO:0005328 neurotransmitter:sodium symporter activity GSVIVG01019361001 370963 405661 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005887 integral to plasma membrane Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01019361001 370963 405661 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01019361001 370963 405661 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01019361001 370963 405661 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005887 integral to plasma membrane Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01019361001 370963 405661 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01019361001 370963 405661 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01019361001 370963 405661 GO:0006836 neurotransmitter transport The directed movement of a neurotransmitter into, out of, within or between cells by means of some external agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. IEA GO:0005887 integral to plasma membrane Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01019361001 370963 405661 GO:0006836 neurotransmitter transport The directed movement of a neurotransmitter into, out of, within or between cells by means of some external agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01019361001 370963 405661 GO:0006836 neurotransmitter transport The directed movement of a neurotransmitter into, out of, within or between cells by means of some external agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01019361001 370963 405661 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0005887 integral to plasma membrane Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01019361001 370963 405661 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01019361001 370963 405661 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01019361001 370963 405661 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005887 integral to plasma membrane Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01019361001 370963 405661 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01019361001 370963 405661 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01019361001 370963 405661 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005887 integral to plasma membrane Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01019361001 370963 405661 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01019361001 370963 405661 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01019361001 370963 405661 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005887 integral to plasma membrane Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01019361001 370963 405661 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01019361001 370963 405661 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01019361001 370963 405661 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005887 integral to plasma membrane Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01019361001 370963 405661 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01019361001 370963 405661 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01019361001 370963 405661 GO:0006836 neurotransmitter transport The directed movement of a neurotransmitter into, out of, within or between cells by means of some external agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. IEA GO:0005887 integral to plasma membrane Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01019361001 370963 405661 GO:0006836 neurotransmitter transport The directed movement of a neurotransmitter into, out of, within or between cells by means of some external agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01019361001 370963 405661 GO:0006836 neurotransmitter transport The directed movement of a neurotransmitter into, out of, within or between cells by means of some external agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01019361001 370963 405661 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0005887 integral to plasma membrane Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01019361001 370963 405661 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01019361001 370963 405661 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01019361001 370963 405661 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005887 integral to plasma membrane Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01019361001 370963 405661 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01019361001 370963 405661 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01019361001 370963 405661 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005887 integral to plasma membrane Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01019361001 370963 405661 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01019361001 370963 405661 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01019361001 370963 405661 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005887 integral to plasma membrane Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01019361001 370963 405661 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01019361001 370963 405661 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01019361001 370963 405661 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005887 integral to plasma membrane Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01019361001 370963 405661 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01019361001 370963 405661 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01019361001 370963 405661 GO:0006836 neurotransmitter transport The directed movement of a neurotransmitter into, out of, within or between cells by means of some external agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. IEA GO:0005887 integral to plasma membrane Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01019361001 370963 405661 GO:0006836 neurotransmitter transport The directed movement of a neurotransmitter into, out of, within or between cells by means of some external agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01019361001 370963 405661 GO:0006836 neurotransmitter transport The directed movement of a neurotransmitter into, out of, within or between cells by means of some external agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01019361001 370963 405661 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0005887 integral to plasma membrane Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01019361001 370963 405661 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01019361001 370963 405661 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01019361001 370963 405661 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005887 integral to plasma membrane Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01019361001 370963 405661 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01019361001 370963 405661 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01019361001 370963 405661 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005887 integral to plasma membrane Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01019361001 370963 405661 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01019361001 370963 405661 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01019361001 370963 405661 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005887 integral to plasma membrane Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01019361001 370963 405661 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01019361001 370963 405661 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01019361001 370963 405661 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005887 integral to plasma membrane Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01019361001 370963 405661 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01019361001 370963 405661 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01019361001 370963 405661 GO:0006836 neurotransmitter transport The directed movement of a neurotransmitter into, out of, within or between cells by means of some external agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. IEA GO:0005887 integral to plasma membrane Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01019361001 370963 405661 GO:0006836 neurotransmitter transport The directed movement of a neurotransmitter into, out of, within or between cells by means of some external agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01019361001 370963 405661 GO:0006836 neurotransmitter transport The directed movement of a neurotransmitter into, out of, within or between cells by means of some external agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01019361001 370963 405661 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0005887 integral to plasma membrane Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01019361001 370963 405661 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01019361001 370963 405661 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01019361001 370963 405661 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005887 integral to plasma membrane Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01019361001 370963 405661 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01019361001 370963 405661 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01019361001 370963 405661 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005887 integral to plasma membrane Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01019361001 370963 405661 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01019361001 370963 405661 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01012774001 23461970 23465483 GSVIVG01026533001 22176307 22182016 GSVIVG01005583001 40709825 40710217 GSVIVG01004920001 4810829 4811634 GSVIVG01033172001 8906595 8911966 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01033172001 8906595 8911966 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01033172001 8906595 8911966 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01029097001 13037455 13039809 GSVIVG01031642001 19485541 19489381 GSVIVG01015270001 2285398 2288849 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01015270001 2285398 2288849 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01015270001 2285398 2288849 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01015270001 2285398 2288849 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01005872001 22409817 22410614 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01005872001 22409817 22410614 Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01033973001 16186419 16192809 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01033973001 16186419 16192809 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01033973001 16186419 16192809 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01033973001 16186419 16192809 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035482001 1648096 1654700 GO:0042398 cellular amino acid derivative biosynthetic process The chemical reactions and pathways resulting in the formation of compounds derived from amino acids, organic acids containing one or more amino substituents. IEA The catalysis of certain rearrangements of a molecule to break or form a ring. IEA GO:0016872 intramolecular lyase activity GSVIVG01027446001 16674193 16675872 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01026030001 25545475 25545983 Interacting selectively and non-covalently with oxygen (O2). IEA GO:0019825 oxygen binding GSVIVG01026030001 25545475 25545983 Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01017856001 4060673 4065629 GO:0006597 spermine biosynthetic process The chemical reactions and pathways resulting in the formation of spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses and involved in nucleic acid packaging. IEA Catalysis of the reaction: S-adenosyl-L-methionine = (5-deoxy-5-adenosyl)(3-aminopropyl) methylsulfonium salt + CO2. IEA GO:0004014 adenosylmethionine decarboxylase activity GSVIVG01017856001 4060673 4065629 GO:0008295 spermidine biosynthetic process The chemical reactions and pathways resulting in the formation of spermidine, N-(3-aminopropyl)-1,4-diaminobutane. IEA Catalysis of the reaction: S-adenosyl-L-methionine = (5-deoxy-5-adenosyl)(3-aminopropyl) methylsulfonium salt + CO2. IEA GO:0004014 adenosylmethionine decarboxylase activity GSVIVG01031004001 20721259 20722778 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar. IEA GO:0008375 acetylglucosaminyltransferase activity GSVIVG01026133001 12726605 12733418 GSVIVG01020765001 2265770 2270113 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020765001 2265770 2270113 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01000334001 11518054 11523487 GSVIVG01006618001 27093997 27097059 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01006618001 27093997 27097059 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01006618001 27093997 27097059 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01006618001 27093997 27097059 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01001085001 22490170 22493936 GSVIVG01015239001 2051450 2053148 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015239001 2051450 2053148 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). IEA GO:0016769 transferase activity, transferring nitrogenous groups GSVIVG01015239001 2051450 2053148 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + methylthioadenosine. IEA GO:0016847 1-aminocyclopropane-1-carboxylate synthase activity GSVIVG01015239001 2051450 2053148 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01011866001 3444539 3445414 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01011866001 3444539 3445414 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01011866001 3444539 3445414 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01011866001 3444539 3445414 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037443001 13660915 13661181 GSVIVG01000830001 2658121 2660128 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01016498001 3371399 3372466 GSVIVG01011947001 2751620 2752908 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01018374001 10173077 10188223 GSVIVG01029235001 18203150 18209756 GSVIVG01019287001 1927054 1931369 Catalysis of the transfer of the amide nitrogen of glutamine to a variety of substrates. GATases catalyze two separate reactions at two active sites, which are located either on a single polypeptide chain or on different subunits. In the glutaminase reaction, glutamine is hydrolyzed to glutamate and ammonia, which is added to an acceptor substrate in the synthase reaction. IEA GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor GSVIVG01019762001 3120418 3123465 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01019762001 3120418 3123465 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01019762001 3120418 3123465 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01019762001 3120418 3123465 GO:0006974 response to DNA damage stimulus A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01019762001 3120418 3123465 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01019762001 3120418 3123465 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01019762001 3120418 3123465 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01019762001 3120418 3123465 GO:0006974 response to DNA damage stimulus A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01025703001 12827655 12830532 GO:0006559 L-phenylalanine catabolic process The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025703001 12827655 12830532 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025703001 12827655 12830532 GO:0006559 L-phenylalanine catabolic process The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of ammonia (NH3) to another substance via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. IEA GO:0016211 ammonia ligase activity GSVIVG01025703001 12827655 12830532 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of ammonia (NH3) to another substance via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. IEA GO:0016211 ammonia ligase activity GSVIVG01025703001 12827655 12830532 GO:0006559 L-phenylalanine catabolic process The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate. IEA GO:0016841 ammonia-lyase activity GSVIVG01025703001 12827655 12830532 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate. IEA GO:0016841 ammonia-lyase activity GSVIVG01011944001 2766597 2767442 GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. IEA GO:0016853 isomerase activity GSVIVG01001153001 1251671 1258313 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01001153001 1251671 1258313 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01020666001 3280522 3283144 GSVIVG01021428001 5238953 5246255 GSVIVG01028137001 4093803 4099869 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01028137001 4093803 4099869 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01028137001 4093803 4099869 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01028137001 4093803 4099869 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028137001 4093803 4099869 Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01028137001 4093803 4099869 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01033819001 17480434 17490347 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA GSVIVG01003211001 7940025 7946828 GO:0007205 activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway The initiation of the activity of the inactive enzyme protein kinase C as the result of a series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol 3-phosphate. IEA GO:0004143 diacylglycerol kinase activity GSVIVG01019289001 1833122 1839200 GSVIVG01034546001 19617944 19618377 GSVIVG01028843001 18138628 18139532 GSVIVG01023330001 19674199 19679214 GSVIVG01003819001 411144 413018 GSVIVG01011006001 2276920 2279610 GSVIVG01000793001 200006 200834 GSVIVG01028158001 4298897 4301308 GO:0016226 iron-sulfur cluster assembly The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01028158001 4298897 4301308 GO:0016226 iron-sulfur cluster assembly The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01020902001 17537906 17558726 GSVIVG01031396001 19141104 19156409 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01031396001 19141104 19156409 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01009273001 6870320 6876771 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01009273001 6870320 6876771 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01009273001 6870320 6876771 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01009273001 6870320 6876771 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01009273001 6870320 6876771 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01009273001 6870320 6876771 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01009273001 6870320 6876771 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01009273001 6870320 6876771 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01028956001 17106361 17111392 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01009578001 9581906 9589816 Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme. IEA GO:0004867 serine-type endopeptidase inhibitor activity GSVIVG01000682001 15403004 15406647 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01000682001 15403004 15406647 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01000682001 15403004 15406647 GO:0015886 heme transport The directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01000682001 15403004 15406647 GO:0017004 cytochrome complex assembly The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01000682001 15403004 15406647 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01000682001 15403004 15406647 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells. IEA GO:0015232 heme transporter activity GSVIVG01000682001 15403004 15406647 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells. IEA GO:0015232 heme transporter activity GSVIVG01000682001 15403004 15406647 GO:0015886 heme transport The directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells. IEA GO:0015232 heme transporter activity GSVIVG01000682001 15403004 15406647 GO:0017004 cytochrome complex assembly The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells. IEA GO:0015232 heme transporter activity GSVIVG01000682001 15403004 15406647 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells. IEA GO:0015232 heme transporter activity GSVIVG01009575001 9549009 9561275 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01009575001 9549009 9561275 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01009575001 9549009 9561275 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01009575001 9549009 9561275 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009682001 10428996 10432146 GO:0006415 translational termination The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code). IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA A translation release factor that is specific for one or more particular termination codons; acts at the ribosomal A-site and require polypeptidyl-tRNA at the P-site. IEA GO:0016149 translation release factor activity, codon specific GSVIVG01025550001 14119059 14119804 GSVIVG01009292001 7033471 7037456 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01028875001 17905499 17910247 GSVIVG01016141001 19633644 19635659 GO:0006887 exocytosis A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell. This is the process whereby most molecules are secreted from eukaryotic cells. IEA GO:0000145 exocyst A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals. IEA GSVIVG01025777001 11975572 11976339 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01025777001 11975572 11976339 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01025777001 11975572 11976339 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01025777001 11975572 11976339 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01025777001 11975572 11976339 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01025777001 11975572 11976339 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01025777001 11975572 11976339 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01025777001 11975572 11976339 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01025777001 11975572 11976339 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01025777001 11975572 11976339 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01025777001 11975572 11976339 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01025777001 11975572 11976339 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01025777001 11975572 11976339 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01025777001 11975572 11976339 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01025777001 11975572 11976339 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01025777001 11975572 11976339 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01025777001 11975572 11976339 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01025777001 11975572 11976339 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01005659001 20870554 20877418 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01015076001 862562 867531 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01015076001 862562 867531 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01015076001 862562 867531 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01015076001 862562 867531 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01033177001 8999309 9004276 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor. IEA GO:0004368 glycerol-3-phosphate dehydrogenase activity GSVIVG01033177001 8999309 9004276 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor. IEA GO:0004368 glycerol-3-phosphate dehydrogenase activity GSVIVG01033177001 8999309 9004276 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033177001 8999309 9004276 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01002261001 33762840 33764234 GSVIVG01032842001 324367 327488 GSVIVG01017035001 3673563 3677202 GSVIVG01014508001 4632191 4632319 GSVIVG01012861001 6312796 6317887 GSVIVG01015826001 17953389 17966632 GSVIVG01016119001 19354200 19354847 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01016119001 19354200 19354847 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01016119001 19354200 19354847 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01016119001 19354200 19354847 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01016119001 19354200 19354847 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01016119001 19354200 19354847 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01003939001 8203829 8210219 GSVIVG01011144001 7180820 7182248 GSVIVG01014047001 9970380 10045231 GSVIVG01037762001 7653783 7658169 GSVIVG01027095001 17983628 17987703 GSVIVG01030055001 9280306 9292495 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the reaction: ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. IEA GO:0004618 phosphoglycerate kinase activity GSVIVG01030055001 9280306 9292495 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01023808001 3311529 3311907 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01026841001 20046328 20057082 GSVIVG01021273001 3261100 3262131 GSVIVG01008195001 4792628 4798676 GO:0007049 cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. IEA GO:0000775 chromosome, centromeric region The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome. IEA GSVIVG01008195001 4792628 4798676 GO:0007049 cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01008195001 4792628 4798676 GO:0007067 mitosis A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell. IEA GO:0000775 chromosome, centromeric region The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome. IEA GSVIVG01008195001 4792628 4798676 GO:0007067 mitosis A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01001176001 1055800 1060957 GSVIVG01032319001 15045626 15046693 GSVIVG01023003001 17040151 17068302 GSVIVG01007840001 8466168 8517606 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01007840001 8466168 8517606 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01015152001 1400373 1404541 GSVIVG01006397001 25603858 25605585 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01006397001 25603858 25605585 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01006397001 25603858 25605585 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01006397001 25603858 25605585 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014410001 3520521 3522543 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01008970001 3937857 3949317 GSVIVG01005224001 19462253 19485464 GSVIVG01018264001 12326262 12327242 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01003944001 13915026 13917461 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003944001 13915026 13917461 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003944001 13915026 13917461 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01003944001 13915026 13917461 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01003944001 13915026 13917461 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01003944001 13915026 13917461 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01003944001 13915026 13917461 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01003944001 13915026 13917461 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01003944001 13915026 13917461 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01003944001 13915026 13917461 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01029136001 19281001 19289435 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01029136001 19281001 19289435 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01029136001 19281001 19289435 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01029136001 19281001 19289435 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01025913001 27303885 27305837 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01035501001 1823202 1829318 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01028054001 3470195 3478722 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01028054001 3470195 3478722 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01028054001 3470195 3478722 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01028054001 3470195 3478722 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028054001 3470195 3478722 Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01028054001 3470195 3478722 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01037473001 13080726 13085918 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01008724001 1457639 1459963 GSVIVG01022475001 3493037 3506886 GSVIVG01036015001 7244098 7247313 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01013459001 299053 304994 GSVIVG01035954001 6416368 6424588 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01032716001 1297730 1301650 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01015131001 1288733 1289595 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a oligosaccharyl group to an acceptor molecule, typically another carbohydrate or a lipid. IEA GO:0004576 oligosaccharyl transferase activity GSVIVG01035174001 12822043 12823842 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of the terminal 1,2-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2). IEA GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity GSVIVG01035174001 12822043 12823842 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01033604001 19385530 19393614 GSVIVG01035248001 11299192 11300619 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA GSVIVG01012071001 1640450 1643813 GSVIVG01024043001 1527929 1528905 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01011258001 10188705 10192208 GSVIVG01009241001 6555820 6559893 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009241001 6555820 6559893 GO:0033014 tetrapyrrole biosynthetic process The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009241001 6555820 6559893 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009241001 6555820 6559893 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: shikimate + NADP+ = 5-dehydroshikimate + NADPH + H+. IEA GO:0004764 shikimate 5-dehydrogenase activity GSVIVG01009241001 6555820 6559893 GO:0033014 tetrapyrrole biosynthetic process The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: shikimate + NADP+ = 5-dehydroshikimate + NADPH + H+. IEA GO:0004764 shikimate 5-dehydrogenase activity GSVIVG01009241001 6555820 6559893 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: shikimate + NADP+ = 5-dehydroshikimate + NADPH + H+. IEA GO:0004764 shikimate 5-dehydrogenase activity GSVIVG01009241001 6555820 6559893 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01009241001 6555820 6559893 GO:0033014 tetrapyrrole biosynthetic process The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01009241001 6555820 6559893 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01009241001 6555820 6559893 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: L-glutamate 1-semialdehyde + NADP+ + tRNA(Glu) = L-glutamyl-tRNA(Glu) + NADPH + H+. IEA GO:0008883 glutamyl-tRNA reductase activity GSVIVG01009241001 6555820 6559893 GO:0033014 tetrapyrrole biosynthetic process The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: L-glutamate 1-semialdehyde + NADP+ + tRNA(Glu) = L-glutamyl-tRNA(Glu) + NADPH + H+. IEA GO:0008883 glutamyl-tRNA reductase activity GSVIVG01009241001 6555820 6559893 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: L-glutamate 1-semialdehyde + NADP+ + tRNA(Glu) = L-glutamyl-tRNA(Glu) + NADPH + H+. IEA GO:0008883 glutamyl-tRNA reductase activity GSVIVG01009241001 6555820 6559893 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01009241001 6555820 6559893 GO:0033014 tetrapyrrole biosynthetic process The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01009241001 6555820 6559893 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01008910001 3338310 3340079 GSVIVG01008442001 2017703 2033911 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01008442001 2017703 2033911 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds. IEA GO:0015035 protein disulfide oxidoreductase activity GSVIVG01016786001 1348843 1370809 GSVIVG01015792001 17484861 17486763 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015792001 17484861 17486763 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01015792001 17484861 17486763 Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01023444001 11819414 11822260 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023444001 11819414 11822260 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023444001 11819414 11822260 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023444001 11819414 11822260 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023444001 11819414 11822260 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023444001 11819414 11822260 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023444001 11819414 11822260 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01023444001 11819414 11822260 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01027729001 7221874 7236640 GSVIVG01018540001 13641986 13646895 GO:0006821 chloride transport The directed movement of chloride into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GSVIVG01018540001 13641986 13646895 GO:0006884 cell volume homeostasis Any process involved in maintaining the steady-state of a cell's volume. The cell's volume refers to the three-dimensional space occupied by a cell. IEA GSVIVG01029754001 14203710 14214730 GSVIVG01000169001 15824524 15838909 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01000169001 15824524 15838909 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01037117001 28949936 28951701 GSVIVG01008967001 3918203 3923619 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01033306001 21643456 21648959 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01033306001 21643456 21648959 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01033306001 21643456 21648959 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01033306001 21643456 21648959 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033306001 21643456 21648959 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033102001 25733854 25736961 GSVIVG01011079001 1766877 1769687 GSVIVG01010467001 20822810 20827657 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01018555001 13450982 13455143 Catalysis of the reversible transfer of a 2-carbon ketol group (CH2OH-CO-) from a ketose phosphate donor to an aldose phosphate acceptor. IEA GO:0004802 transketolase activity GSVIVG01035062001 1260027 1260999 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GSVIVG01035062001 1260027 1260999 GO:0009607 response to biotic stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism. IEA GSVIVG01014729001 9025802 9029915 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01014729001 9025802 9029915 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01014729001 9025802 9029915 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01027150001 17406817 17409766 Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01001083001 22469075 22482650 GO:0016568 chromatin modification The alteration of DNA or protein in chromatin, which may result in changing the chromatin structure. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01001083001 22469075 22482650 GO:0016568 chromatin modification The alteration of DNA or protein in chromatin, which may result in changing the chromatin structure. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives. IEA GO:0018024 histone-lysine N-methyltransferase activity GSVIVG01021860001 6402788 6407018 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01021860001 6402788 6407018 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01021860001 6402788 6407018 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01021860001 6402788 6407018 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01034326001 18107110 18113810 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: diphosphate + H2O = 2 phosphate. IEA GO:0004427 inorganic diphosphatase activity GSVIVG01034326001 18107110 18113810 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: diphosphate + H2O = 2 phosphate. IEA GO:0004427 inorganic diphosphatase activity GSVIVG01034326001 18107110 18113810 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01034326001 18107110 18113810 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01034326001 18107110 18113810 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01034326001 18107110 18113810 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01034326001 18107110 18113810 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01034326001 18107110 18113810 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01034326001 18107110 18113810 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034326001 18107110 18113810 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034326001 18107110 18113810 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of pyrophosphate, which generates a proton motive force. IEA GO:0009678 hydrogen-translocating pyrophosphatase activity GSVIVG01034326001 18107110 18113810 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of pyrophosphate, which generates a proton motive force. IEA GO:0009678 hydrogen-translocating pyrophosphatase activity GSVIVG01028660001 11728401 11781535 GSVIVG01014687001 8623967 8624827 GSVIVG01001252001 4723088 4724342 GSVIVG01036372001 4314735 4318025 Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01036372001 4314735 4318025 Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01026418001 23774951 23783516 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01026418001 23774951 23783516 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01026418001 23774951 23783516 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01026418001 23774951 23783516 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026418001 23774951 23783516 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031576001 18396877 18398637 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01031576001 18396877 18398637 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01031576001 18396877 18398637 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01031576001 18396877 18398637 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01031576001 18396877 18398637 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01031576001 18396877 18398637 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01031576001 18396877 18398637 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01031576001 18396877 18398637 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01030619001 7212797 7214578 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009579 thylakoid A membranous cellular structure that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the plasma membrane. In eukaryotes they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation. IEA GSVIVG01030619001 7212797 7214578 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01001360001 23947407 23949537 GSVIVG01004806001 52587 61123 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01004806001 52587 61123 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01004806001 52587 61123 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01004806001 52587 61123 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01004806001 52587 61123 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030657001 13086270 13087662 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01026230001 14513537 14514407 GSVIVG01016497001 3393814 3396178 GSVIVG01038611001 21495028 21499010 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018024001 5562444 5566707 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01018024001 5562444 5566707 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01018024001 5562444 5566707 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01018024001 5562444 5566707 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01018496001 14301522 14301981 GSVIVG01036927001 17478430 17482898 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin. IEA GO:0004221 ubiquitin thiolesterase activity GSVIVG01025585001 13874841 13876949 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01002271001 33821648 33821881 GSVIVG01031026001 21104059 21114133 GSVIVG01008891001 3197116 3198320 GSVIVG01009642001 10145285 10145615 GSVIVG01019695001 2524250 2527083 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01019695001 2524250 2527083 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024667001 7932473 7935888 GO:0006826 iron ion transport The directed movement of iron (Fe) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024667001 7932473 7935888 GO:0006879 cellular iron ion homeostasis Any process involved in the maintenance of an internal steady-state of iron ions at the level of a cell. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024667001 7932473 7935888 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024667001 7932473 7935888 GO:0006826 iron ion transport The directed movement of iron (Fe) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with ferric iron, Fe(III). IEA GO:0008199 ferric iron binding GSVIVG01024667001 7932473 7935888 GO:0006879 cellular iron ion homeostasis Any process involved in the maintenance of an internal steady-state of iron ions at the level of a cell. IEA Interacting selectively and non-covalently with ferric iron, Fe(III). IEA GO:0008199 ferric iron binding GSVIVG01024667001 7932473 7935888 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with ferric iron, Fe(III). IEA GO:0008199 ferric iron binding GSVIVG01024667001 7932473 7935888 GO:0006826 iron ion transport The directed movement of iron (Fe) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024667001 7932473 7935888 GO:0006879 cellular iron ion homeostasis Any process involved in the maintenance of an internal steady-state of iron ions at the level of a cell. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024667001 7932473 7935888 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024667001 7932473 7935888 GO:0006826 iron ion transport The directed movement of iron (Fe) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01024667001 7932473 7935888 GO:0006879 cellular iron ion homeostasis Any process involved in the maintenance of an internal steady-state of iron ions at the level of a cell. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01024667001 7932473 7935888 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01025594001 13768899 13771838 GO:0006887 exocytosis A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell. This is the process whereby most molecules are secreted from eukaryotic cells. IEA GO:0000145 exocyst A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals. IEA GSVIVG01004110001 14913784 14916398 GSVIVG01009741001 10905064 10905253 GSVIVG01005342001 39825557 39826099 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01026534001 22169178 22170552 GSVIVG01029978001 2609877 2636253 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. IEA GO:0016836 hydro-lyase activity GSVIVG01029978001 2609877 2636253 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. IEA GO:0016836 hydro-lyase activity GSVIVG01029978001 2609877 2636253 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051539 4 iron, 4 sulfur cluster binding GSVIVG01029978001 2609877 2636253 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051539 4 iron, 4 sulfur cluster binding GSVIVG01037243001 16960975 16961723 GSVIVG01029707001 13459847 13482898 Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01029707001 13459847 13482898 Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01032587001 28592565 28599544 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01032587001 28592565 28599544 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nucleotidyl group to a reactant. IEA GO:0016779 nucleotidyltransferase activity GSVIVG01014893001 11315854 11316430 Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01014893001 11315854 11316430 Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01001804001 25952223 25964387 GO:0009116 nucleoside metabolic process The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine). IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01001804001 25952223 25964387 GO:0009116 nucleoside metabolic process The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine). IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001804001 25952223 25964387 GO:0009116 nucleoside metabolic process The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine). IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01016637001 2278834 2284853 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01016637001 2278834 2284853 GO:0016311 dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01016637001 2278834 2284853 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. IEA GO:0004725 protein tyrosine phosphatase activity GSVIVG01016637001 2278834 2284853 GO:0016311 dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. IEA Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. IEA GO:0004725 protein tyrosine phosphatase activity GSVIVG01016637001 2278834 2284853 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA Catalysis of the reaction: protein serine/threonine/tyrosine phosphate + H2O = protein serine/threonine/tyrosine + phosphate. IEA GO:0008138 protein tyrosine/serine/threonine phosphatase activity GSVIVG01016637001 2278834 2284853 GO:0016311 dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. IEA Catalysis of the reaction: protein serine/threonine/tyrosine phosphate + H2O = protein serine/threonine/tyrosine + phosphate. IEA GO:0008138 protein tyrosine/serine/threonine phosphatase activity GSVIVG01016637001 2278834 2284853 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. IEA GO:0016791 phosphatase activity GSVIVG01016637001 2278834 2284853 GO:0016311 dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. IEA Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. IEA GO:0016791 phosphatase activity GSVIVG01016978001 3127713 3129353 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01034639001 13565981 13566607 GSVIVG01033069001 25538644 25540114 GSVIVG01024998001 5391170 5399972 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01024998001 5391170 5399972 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01007704001 10194239 10198544 GSVIVG01037622001 6307464 6321572 GO:0006278 RNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01037622001 6307464 6321572 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01037622001 6307464 6321572 GO:0006278 RNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. IEA Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time. IEA GO:0003964 RNA-directed DNA polymerase activity GSVIVG01037622001 6307464 6321572 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time. IEA GO:0003964 RNA-directed DNA polymerase activity GSVIVG01037622001 6307464 6321572 GO:0006278 RNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01037622001 6307464 6321572 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01037622001 6307464 6321572 GO:0006278 RNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01037622001 6307464 6321572 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01037622001 6307464 6321572 GO:0006278 RNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01037622001 6307464 6321572 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01037622001 6307464 6321572 GO:0006278 RNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01037622001 6307464 6321572 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01012086001 1562719 1563250 GSVIVG01001372001 24067554 24072138 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01001372001 24067554 24072138 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01001372001 24067554 24072138 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001372001 24067554 24072138 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01003580001 10900073 10901059 GSVIVG01011306001 8212098 8224960 Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01011306001 8212098 8224960 Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01019705001 2582337 2582732 GSVIVG01027027001 18502075 18503302 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027027001 18502075 18503302 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027027001 18502075 18503302 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027027001 18502075 18503302 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01027027001 18502075 18503302 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01027027001 18502075 18503302 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01027027001 18502075 18503302 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01027027001 18502075 18503302 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01027027001 18502075 18503302 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01027027001 18502075 18503302 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01027027001 18502075 18503302 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01027027001 18502075 18503302 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01027027001 18502075 18503302 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01027027001 18502075 18503302 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01027027001 18502075 18503302 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01027027001 18502075 18503302 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01027027001 18502075 18503302 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01027027001 18502075 18503302 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01025704001 12821394 12826466 GO:0006099 tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01025704001 12821394 12826466 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01025704001 12821394 12826466 GO:0006099 tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of the reaction: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH + H+. IEA GO:0004449 isocitrate dehydrogenase (NAD+) activity GSVIVG01025704001 12821394 12826466 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of the reaction: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH + H+. IEA GO:0004449 isocitrate dehydrogenase (NAD+) activity GSVIVG01025704001 12821394 12826466 GO:0006099 tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01025704001 12821394 12826466 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01025704001 12821394 12826466 GO:0006099 tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01025704001 12821394 12826466 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01020224001 8860602 8865591 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01020224001 8860602 8865591 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033905001 16840871 16844896 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01033905001 16840871 16844896 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01033905001 16840871 16844896 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. IEA GO:0005096 GTPase activator activity GSVIVG01033905001 16840871 16844896 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. IEA GO:0005096 GTPase activator activity GSVIVG01028342001 6288459 6290095 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01031467001 18243778 18247181 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031467001 18243778 18247181 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01030805001 16360138 16361670 GSVIVG01038307001 12572758 12574529 GSVIVG01011919001 3011620 3013762 GSVIVG01033418001 20865379 20866714 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01008410001 2360667 2363479 GSVIVG01031276001 652647 654105 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01031080001 2556320 2557181 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with manganese (Mn) ions. IEA GO:0030145 manganese ion binding GSVIVG01031080001 2556320 2557181 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Functions in the storage of nutritious substrates. IEA GO:0045735 nutrient reservoir activity GSVIVG01035303001 202217 211948 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01035303001 202217 211948 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01035303001 202217 211948 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01035303001 202217 211948 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035303001 202217 211948 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003701001 15259649 15260585 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. IEA GO:0016597 amino acid binding GSVIVG01003701001 15259649 15260585 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. IEA GO:0016597 amino acid binding GSVIVG01003701001 15259649 15260585 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01003701001 15259649 15260585 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01011814001 3891703 3907393 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01011814001 3891703 3907393 GO:0031123 RNA 3'-end processing Any process involved in forming the mature 3' end of an RNA molecule. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01011814001 3891703 3907393 GO:0043631 RNA polyadenylation The enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01011814001 3891703 3907393 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the template-independent extension of the 3'- end of an RNA or DNA strand by addition of one adenosine molecule at a time. Cannot initiate a chain 'de novo'. The primer, depending on the source of the enzyme, may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group. IEA GO:0004652 polynucleotide adenylyltransferase activity GSVIVG01011814001 3891703 3907393 GO:0031123 RNA 3'-end processing Any process involved in forming the mature 3' end of an RNA molecule. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the template-independent extension of the 3'- end of an RNA or DNA strand by addition of one adenosine molecule at a time. Cannot initiate a chain 'de novo'. The primer, depending on the source of the enzyme, may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group. IEA GO:0004652 polynucleotide adenylyltransferase activity GSVIVG01011814001 3891703 3907393 GO:0043631 RNA polyadenylation The enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the template-independent extension of the 3'- end of an RNA or DNA strand by addition of one adenosine molecule at a time. Cannot initiate a chain 'de novo'. The primer, depending on the source of the enzyme, may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group. IEA GO:0004652 polynucleotide adenylyltransferase activity GSVIVG01011814001 3891703 3907393 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the transfer of a nucleotidyl group to a reactant. IEA GO:0016779 nucleotidyltransferase activity GSVIVG01011814001 3891703 3907393 GO:0031123 RNA 3'-end processing Any process involved in forming the mature 3' end of an RNA molecule. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the transfer of a nucleotidyl group to a reactant. IEA GO:0016779 nucleotidyltransferase activity GSVIVG01011814001 3891703 3907393 GO:0043631 RNA polyadenylation The enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the transfer of a nucleotidyl group to a reactant. IEA GO:0016779 nucleotidyltransferase activity GSVIVG01024424001 2435639 2439122 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031836001 4776570 4781661 GSVIVG01028000001 3103746 3106308 GSVIVG01030366001 5032120 5034498 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01004512001 38951993 38953120 GSVIVG01011630001 5758617 5758826 GSVIVG01007279001 31231656 31235287 GSVIVG01029474001 22440957 22463868 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029474001 22440957 22463868 Catalysis of the transfer of a functional group from one position to another within a single molecule. IEA GO:0016866 intramolecular transferase activity GSVIVG01012382001 297879 301168 GSVIVG01003690001 12237768 12239265 GSVIVG01018561001 13375762 13376570 GSVIVG01022982001 17321659 17323832 GSVIVG01011803001 4021808 4024536 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01011803001 4021808 4024536 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01011803001 4021808 4024536 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01011803001 4021808 4024536 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01001882001 6722716 6722817 GSVIVG01024730001 7387506 7393936 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01024730001 7387506 7393936 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01035393001 961663 979105 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01035393001 961663 979105 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01035393001 961663 979105 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01035393001 961663 979105 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01035393001 961663 979105 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035393001 961663 979105 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035393001 961663 979105 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01035393001 961663 979105 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01035393001 961663 979105 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01035393001 961663 979105 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01025479001 486454 488995 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01019678001 2410591 2413708 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019678001 2410591 2413708 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01019678001 2410591 2413708 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01036535001 23137318 23143930 GSVIVG01008983001 4042008 4046846 GSVIVG01001046001 7020195 7025503 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01001046001 7020195 7025503 GO:0006270 DNA-dependent DNA replication initiation The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01001046001 7020195 7025503 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01001046001 7020195 7025503 GO:0006270 DNA-dependent DNA replication initiation The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01001046001 7020195 7025503 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001046001 7020195 7025503 GO:0006270 DNA-dependent DNA replication initiation The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001046001 7020195 7025503 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01001046001 7020195 7025503 GO:0006270 DNA-dependent DNA replication initiation The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01036826001 17598951 17599277 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01029601001 20876871 20898036 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of the terminal 1,2-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2). IEA GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity GSVIVG01029601001 20876871 20898036 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01019576001 1703996 1704473 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01030755001 15400559 15401694 GSVIVG01011677001 5301658 5310084 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01011677001 5301658 5310084 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01011677001 5301658 5310084 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01011677001 5301658 5310084 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01011677001 5301658 5310084 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037525001 12254017 12256341 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01033359001 21222813 21225586 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01033359001 21222813 21225586 GO:0007047 cellular cell wall organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01033359001 21222813 21225586 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01033359001 21222813 21225586 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01033359001 21222813 21225586 GO:0007047 cellular cell wall organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01033359001 21222813 21225586 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01033359001 21222813 21225586 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01033359001 21222813 21225586 GO:0007047 cellular cell wall organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01033359001 21222813 21225586 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01001391001 24165262 24168786 GSVIVG01013453001 331414 338450 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013453001 331414 338450 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01033291001 21777040 21779538 GSVIVG01037927001 11031132 11032016 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01010291001 19129617 19145392 GSVIVG01026341001 14427681 14430561 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01026341001 14427681 14430561 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01034713001 8239197 8251139 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01034713001 8239197 8251139 GO:0006284 base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01034713001 8239197 8251139 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01034713001 8239197 8251139 GO:0006284 base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01034713001 8239197 8251139 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. IEA GO:0004519 endonuclease activity GSVIVG01034713001 8239197 8251139 GO:0006284 base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. IEA GO:0004519 endonuclease activity GSVIVG01034713001 8239197 8251139 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051539 4 iron, 4 sulfur cluster binding GSVIVG01034713001 8239197 8251139 GO:0006284 base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. IEA Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051539 4 iron, 4 sulfur cluster binding GSVIVG01007165001 30596800 30600327 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007165001 30596800 30600327 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. IEA GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GSVIVG01034429001 16353639 16361287 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01034429001 16353639 16361287 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01034429001 16353639 16361287 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034429001 16353639 16361287 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034429001 16353639 16361287 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01034429001 16353639 16361287 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01020718001 2778598 2782972 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01037628001 6347041 6349633 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01001202001 844333 847985 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01001202001 844333 847985 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01014200001 1401149 1420720 GO:0006779 porphyrin biosynthetic process The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group. IEA Catalysis of the reaction: uroporphyrinogen-III = coproporphyrinogen + 4 CO2. IEA GO:0004853 uroporphyrinogen decarboxylase activity GSVIVG01014200001 1401149 1420720 GO:0006779 porphyrin biosynthetic process The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01014200001 1401149 1420720 GO:0006779 porphyrin biosynthetic process The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group. IEA Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. IEA GO:0016831 carboxy-lyase activity GSVIVG01018689001 11081882 11083597 GSVIVG01019399001 330476 334581 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019399001 330476 334581 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019399001 330476 334581 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01019399001 330476 334581 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01019399001 330476 334581 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01019399001 330476 334581 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01022951001 17637409 17640074 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009736001 10863823 10873660 GO:0006014 D-ribose metabolic process The chemical reactions and pathways involving D-ribose (ribo-pentose). As beta-D-ribofuranose, D-ribose forms the glycose moiety of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12. IEA Catalysis of the reaction: ATP + D-ribose = ADP + D-ribose 5-phosphate. IEA GO:0004747 ribokinase activity GSVIVG01031901001 5261665 5263653 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01031901001 5261665 5263653 GO:0007596 blood coagulation The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01031901001 5261665 5263653 GO:0015671 oxygen transport The directed movement of oxygen (O2) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01031901001 5261665 5263653 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with thrombin to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state. IEA GO:0015057 thrombin receptor activity GSVIVG01031901001 5261665 5263653 GO:0007596 blood coagulation The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with thrombin to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state. IEA GO:0015057 thrombin receptor activity GSVIVG01031901001 5261665 5263653 GO:0015671 oxygen transport The directed movement of oxygen (O2) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with thrombin to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state. IEA GO:0015057 thrombin receptor activity GSVIVG01031901001 5261665 5263653 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with oxygen (O2). IEA GO:0019825 oxygen binding GSVIVG01031901001 5261665 5263653 GO:0007596 blood coagulation The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with oxygen (O2). IEA GO:0019825 oxygen binding GSVIVG01031901001 5261665 5263653 GO:0015671 oxygen transport The directed movement of oxygen (O2) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with oxygen (O2). IEA GO:0019825 oxygen binding GSVIVG01031901001 5261665 5263653 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01031901001 5261665 5263653 GO:0007596 blood coagulation The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01031901001 5261665 5263653 GO:0015671 oxygen transport The directed movement of oxygen (O2) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01011752001 4546687 4556121 GSVIVG01009829001 11608623 11613651 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01009829001 11608623 11613651 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01009829001 11608623 11613651 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01009829001 11608623 11613651 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01009829001 11608623 11613651 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01009829001 11608623 11613651 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01009829001 11608623 11613651 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01009829001 11608623 11613651 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01009829001 11608623 11613651 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009829001 11608623 11613651 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020688001 3099863 3102455 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01032763001 941694 948344 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01028028001 3278814 3284405 GO:0006364 rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. IEA GO:0032040 small-subunit processome A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins. IEA GSVIVG01026849001 19987159 19988943 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01026849001 19987159 19988943 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01012865001 6355110 6356391 GSVIVG01014852001 10605055 10620089 GO:0006821 chloride transport The directed movement of chloride into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01014852001 10605055 10620089 GO:0006821 chloride transport The directed movement of chloride into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01014852001 10605055 10620089 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01014852001 10605055 10620089 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01014852001 10605055 10620089 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01014852001 10605055 10620089 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01014852001 10605055 10620089 GO:0006821 chloride transport The directed movement of chloride into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a chloride ion by a voltage-gated channel. IEA GO:0005247 voltage-gated chloride channel activity GSVIVG01014852001 10605055 10620089 GO:0006821 chloride transport The directed movement of chloride into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of a chloride ion by a voltage-gated channel. IEA GO:0005247 voltage-gated chloride channel activity GSVIVG01014852001 10605055 10620089 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a chloride ion by a voltage-gated channel. IEA GO:0005247 voltage-gated chloride channel activity GSVIVG01014852001 10605055 10620089 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of a chloride ion by a voltage-gated channel. IEA GO:0005247 voltage-gated chloride channel activity GSVIVG01014852001 10605055 10620089 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a chloride ion by a voltage-gated channel. IEA GO:0005247 voltage-gated chloride channel activity GSVIVG01014852001 10605055 10620089 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of a chloride ion by a voltage-gated channel. IEA GO:0005247 voltage-gated chloride channel activity GSVIVG01014852001 10605055 10620089 GO:0006821 chloride transport The directed movement of chloride into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01014852001 10605055 10620089 GO:0006821 chloride transport The directed movement of chloride into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01014852001 10605055 10620089 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01014852001 10605055 10620089 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01014852001 10605055 10620089 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01014852001 10605055 10620089 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01008625001 321603 329954 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0030173 integral to Golgi membrane Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the Golgi complex membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Catalysis of the formation of sialylglycoconjugates via transfer of the sialic acid group from CMP to one of several glycoconjugate acceptors. IEA GO:0008373 sialyltransferase activity GSVIVG01013602001 1138750 1166279 GO:0006397 mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA GSVIVG01025918001 27243703 27249772 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025918001 27243703 27249772 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025918001 27243703 27249772 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025918001 27243703 27249772 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025918001 27243703 27249772 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025918001 27243703 27249772 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025918001 27243703 27249772 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01025918001 27243703 27249772 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01016855001 2000266 2019317 GSVIVG01029875001 884870 885911 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01029875001 884870 885911 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0009528 plastid inner membrane The inner, i.e. lumen-facing, lipid bilayer of the plastid envelope; also faces the plastid stroma. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01029875001 884870 885911 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01029875001 884870 885911 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0009706 chloroplast inner membrane The inner, i.e. lumen-facing, lipid bilayer of the chloroplast envelope; also faces the chloroplast stroma. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01029875001 884870 885911 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01029875001 884870 885911 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01029875001 884870 885911 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01029875001 884870 885911 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0009528 plastid inner membrane The inner, i.e. lumen-facing, lipid bilayer of the plastid envelope; also faces the plastid stroma. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01029875001 884870 885911 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01029875001 884870 885911 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0009706 chloroplast inner membrane The inner, i.e. lumen-facing, lipid bilayer of the chloroplast envelope; also faces the chloroplast stroma. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01029875001 884870 885911 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01029875001 884870 885911 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01029875001 884870 885911 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01029875001 884870 885911 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0009528 plastid inner membrane The inner, i.e. lumen-facing, lipid bilayer of the plastid envelope; also faces the plastid stroma. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01029875001 884870 885911 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01029875001 884870 885911 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0009706 chloroplast inner membrane The inner, i.e. lumen-facing, lipid bilayer of the chloroplast envelope; also faces the chloroplast stroma. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01029875001 884870 885911 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01029875001 884870 885911 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01008908001 3312010 3316888 GSVIVG01010585001 16343202 16344607 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010585001 16343202 16344607 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010585001 16343202 16344607 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010585001 16343202 16344607 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01010585001 16343202 16344607 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01010585001 16343202 16344607 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01010585001 16343202 16344607 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01010585001 16343202 16344607 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01010585001 16343202 16344607 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01018089001 6388676 6390727 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01018089001 6388676 6390727 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01018089001 6388676 6390727 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01018089001 6388676 6390727 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01018089001 6388676 6390727 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01018089001 6388676 6390727 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01018089001 6388676 6390727 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018089001 6388676 6390727 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025556001 14072939 14074693 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01025556001 14072939 14074693 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01014280001 2291819 2293513 GSVIVG01021246001 2933446 2936076 GSVIVG01001660001 14023104 14027197 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01001660001 14023104 14027197 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001660001 14023104 14027197 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01001660001 14023104 14027197 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01024321001 851233 868465 GSVIVG01024869001 6350885 6358450 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01024869001 6350885 6358450 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01016102001 19000560 19000948 GSVIVG01028978001 16945006 16949623 GSVIVG01001483001 5005024 5007823 GSVIVG01035267001 11644262 11655319 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01035267001 11644262 11655319 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01035267001 11644262 11655319 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01035267001 11644262 11655319 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01035267001 11644262 11655319 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01035267001 11644262 11655319 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035267001 11644262 11655319 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035267001 11644262 11655319 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035267001 11644262 11655319 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035267001 11644262 11655319 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035267001 11644262 11655319 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01035267001 11644262 11655319 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01035267001 11644262 11655319 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01035267001 11644262 11655319 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01035267001 11644262 11655319 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01032050001 23193784 23196791 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01032050001 23193784 23196791 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01032050001 23193784 23196791 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01032050001 23193784 23196791 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor. IEA GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GSVIVG01032050001 23193784 23196791 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01004672001 39498535 39500000 GSVIVG01032245001 13761645 13763896 GSVIVG01002668001 35805535 35807033 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01015656001 15021586 15049296 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Prevents the dissociation of GDP from the small GTPase Rab, thereby preventing GTP from binding. IEA GO:0005093 Rab GDP-dissociation inhibitor activity GSVIVG01015656001 15021586 15049296 GO:0043087 regulation of GTPase activity Any process that modulates the rate of GTP hydrolysis by a GTPase. IEA Prevents the dissociation of GDP from the small GTPase Rab, thereby preventing GTP from binding. IEA GO:0005093 Rab GDP-dissociation inhibitor activity GSVIVG01024262001 340748 344516 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01025433001 835181 839305 GO:0006367 transcription initiation from RNA polymerase II promoter A transcription initiation process that results in RNA synthesis by RNA polymerase II. IEA GO:0005669 transcription factor TFIID complex A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters. IEA Any function that supports basal (unregulated) transcription of genes by core RNA polymerase II. Five general transcription factors are necessary and sufficient for such basal transcription in yeast: TFIIB, TFIID, TFIIE, TFIIF, TFIIH and TATA-binding protein (TBF). IEA GO:0016251 general RNA polymerase II transcription factor activity GSVIVG01031390001 19195969 19197243 GSVIVG01029985001 2727103 2761907 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01029985001 2727103 2761907 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01029985001 2727103 2761907 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01016057001 18141009 18144251 GO:0015886 heme transport The directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells. IEA GO:0015232 heme transporter activity GSVIVG01016057001 18141009 18144251 GO:0017004 cytochrome complex assembly The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells. IEA GO:0015232 heme transporter activity GSVIVG01009362001 7770220 7773282 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01007701001 10235742 10240891 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01018670001 11391037 11391366 GSVIVG01012056001 1747952 1751082 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01012056001 1747952 1751082 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01012056001 1747952 1751082 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01012056001 1747952 1751082 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01034348001 17709407 17717844 GSVIVG01023195001 21253740 21273545 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01023195001 21253740 21273545 GO:0016570 histone modification The covalent alteration of one or more amino acid residues within a histone protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01023195001 21253740 21273545 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023195001 21253740 21273545 GO:0016570 histone modification The covalent alteration of one or more amino acid residues within a histone protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023195001 21253740 21273545 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01023195001 21253740 21273545 GO:0016570 histone modification The covalent alteration of one or more amino acid residues within a histone protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01025337001 1892700 1894922 GSVIVG01010762001 22368714 22378837 GSVIVG01012521001 510348 511639 GSVIVG01012439001 810182 820831 GSVIVG01023129001 22286036 22288111 GSVIVG01037114001 28991563 29014023 GO:0006869 lipid transport The directed movement of lipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of lipids into, out of, within or between cells. IEA GO:0005319 lipid transporter activity GSVIVG01013673001 2383650 2385334 GSVIVG01030662001 13123335 13123866 GSVIVG01002603001 35364354 35365743 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0005839 proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. IEA Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. IEA GO:0004298 threonine-type endopeptidase activity GSVIVG01024681001 7796529 7803855 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01001243001 1886024 1886263 GSVIVG01020877001 17888174 17888734 GSVIVG01034023001 15771369 15777235 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01034023001 15771369 15777235 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01025124001 4228257 4234893 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA GSVIVG01033848001 17265372 17270849 GSVIVG01001672001 14130867 14134399 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01001672001 14130867 14134399 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01001672001 14130867 14134399 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01006141001 42059860 42061054 GSVIVG01000275001 20948698 20960201 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01015165001 1487171 1500725 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01020940001 16816047 16822301 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01020940001 16816047 16822301 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). IEA GO:0016769 transferase activity, transferring nitrogenous groups GSVIVG01020940001 16816047 16822301 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01016875001 2164691 2168597 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GSVIVG01037786001 7850870 7866048 GSVIVG01022018001 4253236 4255595 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01003603001 11176164 11189530 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a specific domain of a protein. IEA GO:0019904 protein domain specific binding GSVIVG01006109001 41612967 41614015 GSVIVG01010621001 15919962 15921566 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01010621001 15919962 15921566 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01010621001 15919962 15921566 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01010621001 15919962 15921566 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01013627001 1879485 1907819 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA Modulates the rate of GTP hydrolysis by a small monomeric GTPase. IEA GO:0005083 small GTPase regulator activity GSVIVG01013627001 1879485 1907819 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA Modulates the rate of GTP hydrolysis by a small monomeric GTPase. IEA GO:0005083 small GTPase regulator activity GSVIVG01013627001 1879485 1907819 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01013627001 1879485 1907819 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01013627001 1879485 1907819 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013627001 1879485 1907819 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017686001 2650045 2654801 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01017686001 2650045 2654801 The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01020645001 3506812 3511196 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01020645001 3506812 3511196 Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. IEA GO:0008171 O-methyltransferase activity GSVIVG01020645001 3506812 3511196 The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01021589001 7565358 7609701 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01021589001 7565358 7609701 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01021589001 7565358 7609701 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021589001 7565358 7609701 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021589001 7565358 7609701 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01021589001 7565358 7609701 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01021589001 7565358 7609701 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01021589001 7565358 7609701 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01021589001 7565358 7609701 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01021589001 7565358 7609701 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01027915001 9346600 9353285 GSVIVG01031592001 18614167 18615558 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01011111001 1483763 1490987 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01018243001 12678624 12679138 GSVIVG01034781001 21443287 21459454 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GSVIVG01015902001 19092611 19104472 GSVIVG01035761001 4067249 4076646 GSVIVG01030564001 6768398 6778933 GSVIVG01019180001 3906158 3907147 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01019180001 3906158 3907147 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01019971001 12171530 12173577 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01024082001 1274979 1279253 GSVIVG01028782001 18887041 18887384 GSVIVG01011148001 7303312 7305732 GSVIVG01008248001 4143098 4144453 GSVIVG01025759001 12158823 12162609 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022232001 17713727 17725589 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01023042001 16477784 16481310 GSVIVG01012938001 13861905 13863458 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01012474001 13613305 13619694 GSVIVG01003256001 8392250 8394286 GSVIVG01014506001 4603005 4612215 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014506001 4603005 4612215 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031763001 4180639 4183390 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01029634001 20384763 20391704 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01029634001 20384763 20391704 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01008228001 4474480 4477370 GO:0012511 monolayer-surrounded lipid storage body A subcellular organelle of plant cells surrounded by 'half-unit' or a monolayer membrane instead of the more usual bilayer. The storage body has a droplet of triglyceride surrounded by a monolayer of phospholipids, interacting with the triglycerides and the hydrophilic head groups facing the cytosol, and containing major protein components called oleosins. IEA GSVIVG01008228001 4474480 4477370 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01023583001 7621506 7623701 GSVIVG01025117001 4284540 4289360 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004197 cysteine-type endopeptidase activity GSVIVG01025117001 4284540 4289360 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01016525001 3120277 3122170 GO:0009664 plant-type cell wall organization A process that results in the assembly and arrangement of constituent parts of the cellulose and pectin-containing cell wall, or in the disassembly of the cellulose and pectin-containing cell wall. This process is carried out at the cellular level. An example of this process is found in Arabidopsis thaliana. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA GSVIVG01016525001 3120277 3122170 GO:0009664 plant-type cell wall organization A process that results in the assembly and arrangement of constituent parts of the cellulose and pectin-containing cell wall, or in the disassembly of the cellulose and pectin-containing cell wall. This process is carried out at the cellular level. An example of this process is found in Arabidopsis thaliana. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01020113001 10226503 10227418 GSVIVG01036559001 23456752 23469960 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate. IEA GO:0004629 phospholipase C activity GSVIVG01036559001 23456752 23469960 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. IEA GO:0008081 phosphoric diester hydrolase activity GSVIVG01034850001 22714888 22715312 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01034850001 22714888 22715312 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01028288001 5701756 5705066 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032956001 24605414 24606138 GO:0006869 lipid transport The directed movement of lipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Interacting selectively and non-covalently with a lipid. IEA GO:0008289 lipid binding GSVIVG01030674001 13359585 13361363 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01014366001 3056793 3068794 GSVIVG01011290001 10678133 10678767 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01000813001 491138 492159 GSVIVG01029808001 15121534 15123816 GSVIVG01004785001 16095327 16097921 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01004785001 16095327 16097921 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01004785001 16095327 16097921 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01004785001 16095327 16097921 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01004785001 16095327 16097921 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01004785001 16095327 16097921 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01004785001 16095327 16097921 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01004785001 16095327 16097921 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01004785001 16095327 16097921 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01004785001 16095327 16097921 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01007712001 10037582 10071108 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0000159 protein phosphatase type 2A complex A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit. IEA Modulation of the activity of the enzyme protein phosphatase type 2A. IEA GO:0008601 protein phosphatase type 2A regulator activity GSVIVG01023508001 10672045 10672693 GSVIVG01018212001 13178840 13190849 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008987001 4069911 4071971 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01008987001 4069911 4071971 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01018922001 18620125 18623814 GSVIVG01017082001 4053840 4058759 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01017082001 4053840 4058759 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate, driving the unwinding of the DNA helix. IEA GO:0004003 ATP-dependent DNA helicase activity GSVIVG01017082001 4053840 4058759 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017082001 4053840 4058759 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01017082001 4053840 4058759 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. IEA GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GSVIVG01005135001 18482986 18484590 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GSVIVG01033841001 17307095 17311457 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01033841001 17307095 17311457 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01033841001 17307095 17311457 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01033841001 17307095 17311457 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01033841001 17307095 17311457 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01033841001 17307095 17311457 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01033841001 17307095 17311457 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01033841001 17307095 17311457 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01018054001 5849436 5858977 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01032994001 24945538 24948000 GSVIVG01035136001 1772317 1774184 GSVIVG01029059001 11603122 11606724 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha1-adrenergic receptors; the activity involves transmitting the signal to the Gq alpha subunit of a heterotrimeric G protein. IEA GO:0004937 alpha1-adrenergic receptor activity GSVIVG01029059001 11603122 11606724 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha1-adrenergic receptors; the activity involves transmitting the signal to the Gq alpha subunit of a heterotrimeric G protein. IEA GO:0004937 alpha1-adrenergic receptor activity GSVIVG01029059001 11603122 11606724 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01029059001 11603122 11606724 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01027520001 16007790 16009779 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01027520001 16007790 16009779 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01036276001 7617607 7629338 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036276001 7617607 7629338 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01015000001 312430 317760 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Stops, prevents or reduces the activity of an enzyme. IEA GO:0004857 enzyme inhibitor activity GSVIVG01015000001 312430 317760 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the reaction: pectin + n H2O = n methanol + pectate. IEA GO:0030599 pectinesterase activity GSVIVG01025636001 13424697 13429619 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: UDP-glucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein = UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein. IEA GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity GSVIVG01003696001 12296836 12319209 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01024814001 6666460 6669604 GO:0006275 regulation of DNA replication Any process that modulates the frequency, rate or extent of DNA replication. IEA GO:0043626 PCNA complex A protein complex composed of three identical PCNA monomers, each comprising two similar domains, which are joined in a head-to-tail arrangement to form a homotrimer. Forms a ring-like structure in solution, with a central hole sufficiently large to accommodate the double helix of DNA. Originally characterized as a DNA sliding clamp for replicative DNA polymerases and as an essential component of the replisome, and has also been shown to be involved in other processes including Okazaki fragment processing, DNA repair, translesion DNA synthesis, DNA methylation, chromatin remodeling and cell cycle regulation. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01024814001 6666460 6669604 GO:0006275 regulation of DNA replication Any process that modulates the frequency, rate or extent of DNA replication. IEA GO:0043626 PCNA complex A protein complex composed of three identical PCNA monomers, each comprising two similar domains, which are joined in a head-to-tail arrangement to form a homotrimer. Forms a ring-like structure in solution, with a central hole sufficiently large to accommodate the double helix of DNA. Originally characterized as a DNA sliding clamp for replicative DNA polymerases and as an essential component of the replisome, and has also been shown to be involved in other processes including Okazaki fragment processing, DNA repair, translesion DNA synthesis, DNA methylation, chromatin remodeling and cell cycle regulation. IEA An enzyme regulator activity that increases the processivity of polymerization by DNA polymerase, by allowing the polymerase to move rapidly along DNA while remaining topologically bound to it. IEA GO:0030337 DNA polymerase processivity factor activity GSVIVG01008990001 4087210 4096373 GO:0006400 tRNA modification The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01008990001 4087210 4096373 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01008990001 4087210 4096373 GO:0006400 tRNA modification The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01008990001 4087210 4096373 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01016196001 6815813 6817818 GSVIVG01036725001 23279325 23283793 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01036725001 23279325 23283793 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01036725001 23279325 23283793 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01036725001 23279325 23283793 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01010871001 16593810 16604677 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01010871001 16593810 16604677 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01010871001 16593810 16604677 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01010871001 16593810 16604677 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01010871001 16593810 16604677 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01010871001 16593810 16604677 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01010871001 16593810 16604677 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01010871001 16593810 16604677 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01035494001 1758028 1786430 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01035494001 1758028 1786430 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01035494001 1758028 1786430 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035494001 1758028 1786430 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01035494001 1758028 1786430 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with double-stranded RNA. IEA GO:0003725 double-stranded RNA binding GSVIVG01035494001 1758028 1786430 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01035494001 1758028 1786430 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt. IEA GO:0004525 ribonuclease III activity GSVIVG01035494001 1758028 1786430 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035494001 1758028 1786430 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01035494001 1758028 1786430 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01035494001 1758028 1786430 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01028064001 3557147 3564625 GSVIVG01029239001 18144211 18168588 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029239001 18144211 18168588 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. IEA GO:0016853 isomerase activity GSVIVG01029239001 18144211 18168588 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01020906001 17471046 17472850 GSVIVG01004852001 62007 65009 GSVIVG01028118001 3956397 3963973 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01028118001 3956397 3963973 GO:0006270 DNA-dependent DNA replication initiation The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01028118001 3956397 3963973 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01028118001 3956397 3963973 GO:0006270 DNA-dependent DNA replication initiation The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01028118001 3956397 3963973 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028118001 3956397 3963973 GO:0006270 DNA-dependent DNA replication initiation The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028118001 3956397 3963973 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01028118001 3956397 3963973 GO:0006270 DNA-dependent DNA replication initiation The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01020322001 21375905 21379426 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020322001 21375905 21379426 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020751001 2352608 2353493 GSVIVG01019974001 12137415 12138997 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01019974001 12137415 12138997 Catalysis of the two-stage endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides with 2',3'-cyclic phosphate intermediates. IEA GO:0033897 ribonuclease T2 activity GSVIVG01035449001 1354828 1355199 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009523 photosystem II A photosystem that contains a pheophytin-quinone reaction center with associated accessory pigments and electron carriers. In cyanobacteria and chloroplasts, in the presence of light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone, whereas other photosynthetic bacteria carry out anoxygenic photosynthesis and oxidize other compounds to re-reduce the photoreaction center. IEA GSVIVG01035449001 1354828 1355199 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01036755001 22972848 22973241 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009872001 11986451 11987978 GSVIVG01008978001 3994150 4000643 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01031241001 928360 935678 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01031241001 928360 935678 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01031241001 928360 935678 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01031241001 928360 935678 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01031241001 928360 935678 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01031241001 928360 935678 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01031241001 928360 935678 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01031241001 928360 935678 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01011788001 4138482 4147477 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Catalysis of the reaction: 4 R'C(R)SH + O2 = 2 R'C(R)S-S(R)CR' + 2 H2O. IEA GO:0016972 thiol oxidase activity GSVIVG01011788001 4138482 4147477 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 4 R'C(R)SH + O2 = 2 R'C(R)S-S(R)CR' + 2 H2O. IEA GO:0016972 thiol oxidase activity GSVIVG01035939001 6187949 6199288 GSVIVG01025014001 5282920 5287142 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025014001 5282920 5287142 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025014001 5282920 5287142 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025014001 5282920 5287142 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025014001 5282920 5287142 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01025014001 5282920 5287142 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01025014001 5282920 5287142 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025014001 5282920 5287142 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025401001 1059245 1060154 GSVIVG01009295001 7060607 7061347 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009295001 7060607 7061347 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009522 photosystem I A photosystem that contains an iron-sulfur reaction center associated with accessory pigments and electron carriers. In cyanobacteria and chloroplasts, photosystem I functions as a light-dependent plastocyanin-ferredoxin oxidoreductase, transferring electrons from plastocyanin to ferredoxin; in photosynthetic bacteria that have only a single type I photosystem, such as the green sulfur bacteria, electrons can go either to ferredoxin (Fd) -> NAD+ or to menaquinone (MK) -> Cytb/FeS -> Cytc555 -> photosystem I (cyclic photophosphorylation). IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009295001 7060607 7061347 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009579 thylakoid A membranous cellular structure that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the plasma membrane. In eukaryotes they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009295001 7060607 7061347 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037778001 7779515 7780996 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01008130001 5528194 5529185 GSVIVG01033813001 17568038 17575443 GSVIVG01026918001 19405379 19414618 GSVIVG01001416001 18902687 18908850 GSVIVG01020782001 2049955 2053435 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020782001 2049955 2053435 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020782001 2049955 2053435 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01020782001 2049955 2053435 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01020782001 2049955 2053435 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01020782001 2049955 2053435 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01016135001 19558984 19561872 GSVIVG01032629001 2046047 2052751 GSVIVG01031746001 4012517 4015118 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031746001 4012517 4015118 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the endohydrolysis of 1,4-alpha-D-glucosidic linkages in polysaccharides containing three or more 1,4-alpha-linked D-glucose units. IEA GO:0004556 alpha-amylase activity GSVIVG01031746001 4012517 4015118 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01031746001 4012517 4015118 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01022892001 18226990 18230199 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014659001 8278980 8284207 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01014659001 8278980 8284207 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01014659001 8278980 8284207 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015688001 15617477 15621957 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016462001 3664787 3668399 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01036551001 23363222 23379548 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01036551001 23363222 23379548 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01036551001 23363222 23379548 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01036551001 23363222 23379548 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01036551001 23363222 23379548 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01036551001 23363222 23379548 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01036551001 23363222 23379548 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01036551001 23363222 23379548 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01036551001 23363222 23379548 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01026328001 14057624 14060289 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01026328001 14057624 14060289 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01026328001 14057624 14060289 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015935 small ribosomal subunit The smaller of the two subunits of a ribosome. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01026328001 14057624 14060289 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01026328001 14057624 14060289 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01026328001 14057624 14060289 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01026328001 14057624 14060289 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015935 small ribosomal subunit The smaller of the two subunits of a ribosome. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01026328001 14057624 14060289 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01011959001 2618634 2632747 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01011959001 2618634 2632747 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01025866001 11028845 11031074 GSVIVG01011026001 2106326 2123593 Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity. IEA GO:0004721 phosphoprotein phosphatase activity GSVIVG01011026001 2106326 2123593 Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01011026001 2106326 2123593 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01011026001 2106326 2123593 Interacting selectively and non-covalently with manganese (Mn) ions. IEA GO:0030145 manganese ion binding GSVIVG01027523001 15995520 15996715 GSVIVG01024342001 1198960 1207819 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01031854001 4923020 4930341 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01031854001 4923020 4930341 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01031854001 4923020 4930341 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01031854001 4923020 4930341 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01000414001 7689952 7691283 Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01000414001 7689952 7691283 Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01038371001 11232828 11238242 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01038371001 11232828 11238242 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029252001 17967412 17982408 GSVIVG01029156001 19019978 19024670 GSVIVG01015522001 4444565 4448287 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01035014001 901141 927705 GSVIVG01029688001 13065135 13099628 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01029688001 13065135 13099628 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01031053001 21470932 21476895 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01031053001 21470932 21476895 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01031053001 21470932 21476895 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01031053001 21470932 21476895 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01031053001 21470932 21476895 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01031053001 21470932 21476895 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01031053001 21470932 21476895 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01031053001 21470932 21476895 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01031053001 21470932 21476895 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01031053001 21470932 21476895 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01031053001 21470932 21476895 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01031053001 21470932 21476895 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0009536 plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01032347001 15357635 15357976 GSVIVG01036049001 21412044 21415848 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01036049001 21412044 21415848 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01032222001 13141860 13149482 GSVIVG01015415001 3427267 3452483 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01015415001 3427267 3452483 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01015415001 3427267 3452483 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01015415001 3427267 3452483 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030885001 18328471 18356529 GO:0016575 histone deacetylation The modification of histones by removal of acetyl groups. IEA Catalysis of the hydrolysis of acetyl groups from histones, proteins complexed to DNA in chromatin and chromosomes. IEA GO:0004407 histone deacetylase activity GSVIVG01030885001 18328471 18356529 GO:0045149 acetoin metabolic process The chemical reactions and pathways involving acetoin, 3-hydroxy-2-butanone, often as part of a fermentation pathway or for use as a carbon source. IEA Catalysis of the hydrolysis of acetyl groups from histones, proteins complexed to DNA in chromatin and chromosomes. IEA GO:0004407 histone deacetylase activity GSVIVG01022247001 17815443 17819261 GO:0016226 iron-sulfur cluster assembly The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01022247001 17815443 17819261 GO:0016226 iron-sulfur cluster assembly The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01029341001 14688580 14720793 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01029341001 14688580 14720793 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01029341001 14688580 14720793 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01029341001 14688580 14720793 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01029341001 14688580 14720793 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01029341001 14688580 14720793 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01029341001 14688580 14720793 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01029341001 14688580 14720793 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01029341001 14688580 14720793 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01029341001 14688580 14720793 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01029341001 14688580 14720793 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01029341001 14688580 14720793 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01029341001 14688580 14720793 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01029341001 14688580 14720793 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01029341001 14688580 14720793 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01029341001 14688580 14720793 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01029341001 14688580 14720793 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029341001 14688580 14720793 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029341001 14688580 14720793 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029341001 14688580 14720793 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029341001 14688580 14720793 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029341001 14688580 14720793 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029341001 14688580 14720793 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029341001 14688580 14720793 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029341001 14688580 14720793 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01029341001 14688580 14720793 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01029341001 14688580 14720793 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01029341001 14688580 14720793 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01029341001 14688580 14720793 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01029341001 14688580 14720793 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01029341001 14688580 14720793 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01029341001 14688580 14720793 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01013166001 7304809 7308522 GSVIVG01004382001 38323439 38329214 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01004382001 38323439 38329214 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01015310001 2567967 2574408 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01015310001 2567967 2574408 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01003923001 13802008 13806798 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01003923001 13802008 13806798 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01017351001 7081985 7082567 GSVIVG01018023001 5552865 5561875 GSVIVG01009803001 11354932 11360265 Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum. IEA GO:0003993 acid phosphatase activity GSVIVG01009803001 11354932 11360265 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01009803001 11354932 11360265 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01037339001 15459993 15488922 GSVIVG01010983001 2440877 2445298 GO:0009416 response to light stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01010983001 2440877 2445298 GO:0009416 response to light stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012066001 1683505 1691145 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0000502 proteasome complex A large multisubunit complex which catalyzes protein degradation. This complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. IEA GO:0004175 endopeptidase activity GSVIVG01012066001 1683505 1691145 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005839 proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. IEA GO:0004175 endopeptidase activity GSVIVG01012066001 1683505 1691145 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0019773 proteasome core complex, alpha-subunit complex The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. IEA GO:0004175 endopeptidase activity GSVIVG01012066001 1683505 1691145 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0000502 proteasome complex A large multisubunit complex which catalyzes protein degradation. This complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. IEA GO:0004175 endopeptidase activity GSVIVG01012066001 1683505 1691145 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0005839 proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. IEA GO:0004175 endopeptidase activity GSVIVG01012066001 1683505 1691145 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0019773 proteasome core complex, alpha-subunit complex The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. IEA GO:0004175 endopeptidase activity GSVIVG01012066001 1683505 1691145 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0000502 proteasome complex A large multisubunit complex which catalyzes protein degradation. This complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core. IEA Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. IEA GO:0004298 threonine-type endopeptidase activity GSVIVG01012066001 1683505 1691145 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005839 proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. IEA Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. IEA GO:0004298 threonine-type endopeptidase activity GSVIVG01012066001 1683505 1691145 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0019773 proteasome core complex, alpha-subunit complex The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. IEA GO:0004298 threonine-type endopeptidase activity GSVIVG01012066001 1683505 1691145 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0000502 proteasome complex A large multisubunit complex which catalyzes protein degradation. This complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core. IEA Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. IEA GO:0004298 threonine-type endopeptidase activity GSVIVG01012066001 1683505 1691145 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0005839 proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. IEA Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. IEA GO:0004298 threonine-type endopeptidase activity GSVIVG01012066001 1683505 1691145 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0019773 proteasome core complex, alpha-subunit complex The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. IEA GO:0004298 threonine-type endopeptidase activity GSVIVG01012066001 1683505 1691145 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0000502 proteasome complex A large multisubunit complex which catalyzes protein degradation. This complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01012066001 1683505 1691145 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005839 proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01012066001 1683505 1691145 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0019773 proteasome core complex, alpha-subunit complex The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01012066001 1683505 1691145 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0000502 proteasome complex A large multisubunit complex which catalyzes protein degradation. This complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01012066001 1683505 1691145 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0005839 proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01012066001 1683505 1691145 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0019773 proteasome core complex, alpha-subunit complex The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01012066001 1683505 1691145 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0000502 proteasome complex A large multisubunit complex which catalyzes protein degradation. This complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01012066001 1683505 1691145 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005839 proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01012066001 1683505 1691145 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0019773 proteasome core complex, alpha-subunit complex The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01012066001 1683505 1691145 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0000502 proteasome complex A large multisubunit complex which catalyzes protein degradation. This complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01012066001 1683505 1691145 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0005839 proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01012066001 1683505 1691145 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0019773 proteasome core complex, alpha-subunit complex The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01028918001 17566981 17576243 GSVIVG01016009001 17274061 17285685 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01011013001 2206708 2213326 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01011013001 2206708 2213326 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01011013001 2206708 2213326 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01021560001 7078305 7079244 GSVIVG01012657001 392977 396081 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01012657001 392977 396081 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01012657001 392977 396081 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01012657001 392977 396081 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01012657001 392977 396081 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033546001 19850835 19853893 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01033546001 19850835 19853893 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01035442001 1292383 1296907 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035442001 1292383 1296907 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01014684001 8597170 8601079 GSVIVG01030259001 9793737 9796005 GSVIVG01038407001 11842541 11848247 GSVIVG01038188001 24201071 24206704 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01038188001 24201071 24206704 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01038188001 24201071 24206704 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with 5S ribosomal RNA, the smallest RNA constituent of a ribosome. IEA GO:0008097 5S rRNA binding GSVIVG01038188001 24201071 24206704 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with 5S ribosomal RNA, the smallest RNA constituent of a ribosome. IEA GO:0008097 5S rRNA binding GSVIVG01007659001 10769897 10770858 GSVIVG01028085001 3696986 3697957 GSVIVG01018260001 12342514 12344317 GSVIVG01035702001 3443682 3465344 GSVIVG01028665001 11865361 11867694 GSVIVG01008086001 5930102 5937499 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01022797001 16688398 16693728 GSVIVG01012923001 13601784 13602643 GSVIVG01012737001 1119820 1125482 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01012737001 1119820 1125482 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01012737001 1119820 1125482 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01012737001 1119820 1125482 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01012669001 488490 496783 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar. IEA GO:0008375 acetylglucosaminyltransferase activity GSVIVG01037457001 13331132 13331730 GSVIVG01009313001 7290696 7292423 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01037283001 16500480 16501356 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01018293001 11651028 11665356 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01018293001 11651028 11665356 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01018293001 11651028 11665356 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01018293001 11651028 11665356 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023849001 2992544 2996671 GSVIVG01023502001 10854656 10866444 GO:0018346 protein amino acid prenylation The covalent attachment of a prenyl moiety to a protein amino acid. IEA Catalysis of the covalent addition of an isoprenoid group such as a farnesyl or geranylgeranyl group via thioether linkages to a cysteine residue in a protein. IEA GO:0008318 protein prenyltransferase activity GSVIVG01033099001 25707708 25712863 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01033099001 25707708 25712863 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033099001 25707708 25712863 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with molybdenum (Mo) ions. IEA GO:0030151 molybdenum ion binding GSVIVG01033099001 25707708 25712863 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01012153001 995577 997132 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012153001 995577 997132 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2-phosphoglycolate + H2O = glycolate + phosphate. IEA GO:0008967 phosphoglycolate phosphatase activity GSVIVG01012153001 995577 997132 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01001668001 14109274 14109357 GSVIVG01038007001 12433382 12434323 GSVIVG01004856001 127975 129356 GSVIVG01026710001 5295151 5295894 GSVIVG01029950001 2032342 2037530 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01029950001 2032342 2037530 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01029950001 2032342 2037530 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01029950001 2032342 2037530 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029950001 2032342 2037530 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000299001 2628682 2638367 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01000299001 2628682 2638367 Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium. IEA GO:0005544 calcium-dependent phospholipid binding GSVIVG01024072001 1357404 1360565 GSVIVG01010510001 21202170 21215480 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. IEA GO:0005516 calmodulin binding GSVIVG01010510001 21202170 21215480 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01021685001 9357356 9407963 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01021685001 9357356 9407963 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01021685001 9357356 9407963 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01021685001 9357356 9407963 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01021685001 9357356 9407963 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025139001 4035310 4037390 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with manganese (Mn) ions. IEA GO:0030145 manganese ion binding GSVIVG01025139001 4035310 4037390 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Functions in the storage of nutritious substrates. IEA GO:0045735 nutrient reservoir activity GSVIVG01011936001 2886712 2897835 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GSVIVG01021427001 5235510 5238887 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021427001 5235510 5238887 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021427001 5235510 5238887 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01021427001 5235510 5238887 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01021427001 5235510 5238887 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01021427001 5235510 5238887 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01028180001 4456526 4458027 GSVIVG01030023001 8982276 8983976 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01030023001 8982276 8983976 GO:0007047 cellular cell wall organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01030023001 8982276 8983976 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01030023001 8982276 8983976 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01030023001 8982276 8983976 GO:0007047 cellular cell wall organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01030023001 8982276 8983976 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01030023001 8982276 8983976 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01030023001 8982276 8983976 GO:0007047 cellular cell wall organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01030023001 8982276 8983976 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01027448001 16662903 16665185 Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. IEA GO:0008171 O-methyltransferase activity GSVIVG01021005001 15512472 15515241 GO:0006621 protein retention in ER lumen The retention in the endoplasmic reticulum (ER) lumen of soluble resident proteins. Sorting receptors retrieve proteins with ER localization signals, such as KDEL and HDEL sequences or some transmembrane domains, that have escaped to the cis-Golgi network and return them to the ER. Abnormally folded proteins and unassembled subunits are also selectively retained in the ER. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with an endoplasmic reticulum (ER) retention sequence, a specific peptide sequence that ensures a protein is retained within the ER. IEA GO:0046923 ER retention sequence binding GSVIVG01017959001 5085636 5088671 GO:0009308 amine metabolic process The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01017959001 5085636 5088671 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01017959001 5085636 5088671 GO:0009308 amine metabolic process The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. IEA Catalysis of the reaction: R-CH2-NH2 + H2O + O2 = R-CHO + NH3 + H2O2. IEA GO:0008131 amine oxidase activity GSVIVG01017959001 5085636 5088671 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: R-CH2-NH2 + H2O + O2 = R-CHO + NH3 + H2O2. IEA GO:0008131 amine oxidase activity GSVIVG01017959001 5085636 5088671 GO:0009308 amine metabolic process The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. IEA Interacting selectively and non-covalently with a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds. IEA GO:0048038 quinone binding GSVIVG01017959001 5085636 5088671 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds. IEA GO:0048038 quinone binding GSVIVG01003920001 13671593 13676664 GO:0007205 activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway The initiation of the activity of the inactive enzyme protein kinase C as the result of a series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol 3-phosphate. IEA GO:0004143 diacylglycerol kinase activity GSVIVG01020501001 18332102 18339207 GO:0006467 protein thiol-disulfide exchange Oxidation of two organic sulfhydryl groups (thiols) by a disulfide compound to form a disulfide bond. IEA GO:0005789 endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020501001 18332102 18339207 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005789 endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020501001 18332102 18339207 GO:0006467 protein thiol-disulfide exchange Oxidation of two organic sulfhydryl groups (thiols) by a disulfide compound to form a disulfide bond. IEA GO:0005789 endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum. IEA Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide. IEA GO:0016671 oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor GSVIVG01020501001 18332102 18339207 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005789 endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum. IEA Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide. IEA GO:0016671 oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor GSVIVG01020501001 18332102 18339207 GO:0006467 protein thiol-disulfide exchange Oxidation of two organic sulfhydryl groups (thiols) by a disulfide compound to form a disulfide bond. IEA GO:0005789 endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01020501001 18332102 18339207 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005789 endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01023366001 19255640 19256013 GSVIVG01035518001 1953599 1957566 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01003282001 14104925 14105945 GSVIVG01021733001 10214337 10215409 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021733001 10214337 10215409 Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01022960001 17554259 17554667 GSVIVG01004596001 39156427 39157012 GSVIVG01007841001 8459181 8463972 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01007841001 8459181 8463972 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01007841001 8459181 8463972 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01007841001 8459181 8463972 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030002001 8860262 8863201 The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01027161001 17343697 17345623 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01027161001 17343697 17345623 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01027161001 17343697 17345623 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01027161001 17343697 17345623 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01027161001 17343697 17345623 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01027161001 17343697 17345623 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01013931001 6973917 6979318 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01013931001 6973917 6979318 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01037088001 29278845 29285761 GSVIVG01001675001 14160239 14172215 GSVIVG01016585001 2605687 2630524 GSVIVG01006518001 42752187 42753741 GSVIVG01021841001 6618656 6629663 GSVIVG01000047001 3063647 3072319 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01000047001 3063647 3072319 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01000047001 3063647 3072319 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01000047001 3063647 3072319 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029289001 17458617 17461298 GO:0046836 glycolipid transport The directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Enables the directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of, within or between cells. IEA GO:0017089 glycolipid transporter activity GSVIVG01029289001 17458617 17461298 GO:0046836 glycolipid transport The directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a glycolipid, any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic moiety such as an acylglycerol, a sphingoid, a ceramide (N-acylsphingoid) or a prenyl phosphate. IEA GO:0051861 glycolipid binding GSVIVG01028888001 17811949 17812491 GSVIVG01022265001 18007778 18012891 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin. IEA GO:0004221 ubiquitin thiolesterase activity GSVIVG01022265001 18007778 18012891 GO:0019941 modification-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein. IEA Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin. IEA GO:0004221 ubiquitin thiolesterase activity GSVIVG01022265001 18007778 18012891 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01022265001 18007778 18012891 GO:0019941 modification-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01022265001 18007778 18012891 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01022265001 18007778 18012891 GO:0019941 modification-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01022265001 18007778 18012891 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01022265001 18007778 18012891 GO:0019941 modification-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01036105001 20623548 20644099 GSVIVG01018483001 14444939 14477574 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01018483001 14444939 14477574 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01018483001 14444939 14477574 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01018483001 14444939 14477574 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01018483001 14444939 14477574 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01018483001 14444939 14477574 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01018483001 14444939 14477574 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01018483001 14444939 14477574 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01017596001 11125394 11126761 GSVIVG01004383001 38329238 38331958 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01004383001 38329238 38331958 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01004383001 38329238 38331958 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01004383001 38329238 38331958 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033524001 20025272 20030878 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of proteins into, out of, within or between cells. IEA GO:0008565 protein transporter activity GSVIVG01022024001 4170136 4175814 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01022024001 4170136 4175814 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01022024001 4170136 4175814 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01022024001 4170136 4175814 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01000857001 3130748 3134457 GSVIVG01035342001 632643 638222 GSVIVG01006396001 25598830 25602976 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01006396001 25598830 25602976 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01006396001 25598830 25602976 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01006396001 25598830 25602976 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01006396001 25598830 25602976 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01006396001 25598830 25602976 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01006396001 25598830 25602976 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01006396001 25598830 25602976 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01017725001 2953486 2954622 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA GSVIVG01013339001 12337959 12338231 GSVIVG01010308001 19257335 19258407 GSVIVG01011842001 3716034 3718950 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01011842001 3716034 3718950 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01011842001 3716034 3718950 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01011842001 3716034 3718950 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01011842001 3716034 3718950 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013330001 12175470 12176452 GSVIVG01026650001 20725983 20733193 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01026650001 20725983 20733193 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01026650001 20725983 20733193 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01026650001 20725983 20733193 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021322001 4018498 4023676 GSVIVG01010572001 16511216 16517255 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010572001 16511216 16517255 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010572001 16511216 16517255 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010572001 16511216 16517255 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01010572001 16511216 16517255 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01010572001 16511216 16517255 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01010572001 16511216 16517255 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01010572001 16511216 16517255 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01010572001 16511216 16517255 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01016350001 4738916 4740142 GSVIVG01038707001 20787349 20792059 GSVIVG01037072001 8193838 8195519 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004185 serine-type carboxypeptidase activity GSVIVG01016207001 6609098 6621713 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0000159 protein phosphatase type 2A complex A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit. IEA Modulation of the activity of the enzyme protein phosphatase type 2A. IEA GO:0008601 protein phosphatase type 2A regulator activity GSVIVG01026851001 19972312 19977742 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01025375001 1255182 1256079 GSVIVG01036321001 3766450 3776056 Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01036321001 3766450 3776056 Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01034253001 13521416 13522967 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01017375001 7527753 7528042 GSVIVG01018953001 18396752 18400758 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01018953001 18396752 18400758 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01018953001 18396752 18400758 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01018953001 18396752 18400758 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01018953001 18396752 18400758 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01018953001 18396752 18400758 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01021843001 6600425 6613836 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01021843001 6600425 6613836 GO:0016117 carotenoid biosynthetic process The chemical reactions and pathways resulting in the formation of carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01021843001 6600425 6613836 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01021843001 6600425 6613836 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01021843001 6600425 6613836 GO:0016117 carotenoid biosynthetic process The chemical reactions and pathways resulting in the formation of carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01021843001 6600425 6613836 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01021843001 6600425 6613836 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the reaction: neurosporene + donor-H2 + O2 = lycopene + acceptor + 2 H2O. IEA GO:0016719 carotene 7,8-desaturase activity GSVIVG01021843001 6600425 6613836 GO:0016117 carotenoid biosynthetic process The chemical reactions and pathways resulting in the formation of carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail. IEA Catalysis of the reaction: neurosporene + donor-H2 + O2 = lycopene + acceptor + 2 H2O. IEA GO:0016719 carotene 7,8-desaturase activity GSVIVG01021843001 6600425 6613836 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: neurosporene + donor-H2 + O2 = lycopene + acceptor + 2 H2O. IEA GO:0016719 carotene 7,8-desaturase activity GSVIVG01021843001 6600425 6613836 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01021843001 6600425 6613836 GO:0016117 carotenoid biosynthetic process The chemical reactions and pathways resulting in the formation of carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01021843001 6600425 6613836 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01021843001 6600425 6613836 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01021843001 6600425 6613836 GO:0016117 carotenoid biosynthetic process The chemical reactions and pathways resulting in the formation of carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01021843001 6600425 6613836 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01028785001 18853685 18860368 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01028785001 18853685 18860368 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01028785001 18853685 18860368 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01028785001 18853685 18860368 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01028785001 18853685 18860368 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01028785001 18853685 18860368 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01028785001 18853685 18860368 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028785001 18853685 18860368 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028785001 18853685 18860368 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01028785001 18853685 18860368 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01025946001 26856807 26884582 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025946001 26856807 26884582 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025946001 26856807 26884582 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025946001 26856807 26884582 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025946001 26856807 26884582 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01025946001 26856807 26884582 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01025946001 26856807 26884582 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the transfer of a nucleotidyl group to a reactant. IEA GO:0016779 nucleotidyltransferase activity GSVIVG01025946001 26856807 26884582 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nucleotidyl group to a reactant. IEA GO:0016779 nucleotidyltransferase activity GSVIVG01027937001 9760804 9763204 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA Catalysis of the transfer of the amide nitrogen of glutamine to a variety of substrates. GATases catalyze two separate reactions at two active sites, which are located either on a single polypeptide chain or on different subunits. In the glutaminase reaction, glutamine is hydrolyzed to glutamate and ammonia, which is added to an acceptor substrate in the synthase reaction. IEA GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor GSVIVG01012660001 412223 413834 GSVIVG01019663001 2309712 2311891 GSVIVG01031487001 17997583 18027638 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GSVIVG01033504001 20200948 20201645 GO:0009790 embryo development The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant. IEA GSVIVG01014496001 4489359 4490254 GSVIVG01017604001 1950534 1953765 GSVIVG01009755001 11011765 11016811 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009755001 11011765 11016811 Catalysis of the reaction: ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol hexakisphosphate. IEA GO:0035299 inositol pentakisphosphate 2-kinase activity GSVIVG01022025001 4161656 4169645 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01022025001 4161656 4169645 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01022025001 4161656 4169645 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01022025001 4161656 4169645 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01010761001 22363162 22367947 GSVIVG01019918001 4445125 4451530 GSVIVG01019995001 11852728 11860193 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01023792001 3436869 3442629 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01023792001 3436869 3442629 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01029243001 18119240 18120755 GSVIVG01027588001 15268031 15269562 GSVIVG01019751001 2967216 2971090 GSVIVG01030121001 10034401 10047884 GSVIVG01012994001 10491214 10506570 GSVIVG01021669001 9019011 9026194 GSVIVG01008890001 3190006 3192536 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01015991001 16881847 16883252 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01015991001 16881847 16883252 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01035376001 871394 877594 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01016911001 2473437 2474879 GSVIVG01030530001 6519186 6524292 GO:0009245 lipid A biosynthetic process The chemical reactions and pathways resulting in the formation of lipid A, the glycolipid moiety of bacterial lipopolysaccharides, consisting of six fatty acyl chains linked to two glucosamine residues. IEA Catalysis of the reaction: UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. IEA GO:0008915 lipid-A-disaccharide synthase activity GSVIVG01033050001 25336099 25342524 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01033050001 25336099 25342524 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01033050001 25336099 25342524 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01033050001 25336099 25342524 GO:0042254 ribosome biogenesis The process of the formation of the constituents of the ribosome subunits, their assembly, and their transport to the sites of protein synthesis. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01033050001 25336099 25342524 GO:0042254 ribosome biogenesis The process of the formation of the constituents of the ribosome subunits, their assembly, and their transport to the sites of protein synthesis. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01033050001 25336099 25342524 GO:0042254 ribosome biogenesis The process of the formation of the constituents of the ribosome subunits, their assembly, and their transport to the sites of protein synthesis. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01014441001 3785444 3802981 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. IEA GO:0004519 endonuclease activity GSVIVG01014441001 3785444 3802981 GO:0006302 double-strand break repair The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. IEA GO:0004519 endonuclease activity GSVIVG01014441001 3785444 3802981 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end. IEA GO:0004527 exonuclease activity GSVIVG01014441001 3785444 3802981 GO:0006302 double-strand break repair The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end. IEA GO:0004527 exonuclease activity GSVIVG01014441001 3785444 3802981 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01014441001 3785444 3802981 GO:0006302 double-strand break repair The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01014441001 3785444 3802981 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with manganese (Mn) ions. IEA GO:0030145 manganese ion binding GSVIVG01014441001 3785444 3802981 GO:0006302 double-strand break repair The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with manganese (Mn) ions. IEA GO:0030145 manganese ion binding GSVIVG01001584001 5560232 5562567 GSVIVG01023569001 9492147 9493567 GSVIVG01025204001 3340661 3345965 GSVIVG01028055001 3482977 3484195 GSVIVG01025917001 27252795 27252944 GSVIVG01025957001 26610910 26614456 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013061001 8916390 8916758 GSVIVG01036109001 20573210 20580981 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA GSVIVG01032571001 28470202 28474988 GSVIVG01032453001 27565314 27571838 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01032453001 27565314 27571838 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01035491001 1721859 1726565 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01037705001 7112182 7119503 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01037705001 7112182 7119503 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017670001 2509331 2521854 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. IEA GO:0005516 calmodulin binding GSVIVG01017670001 2509331 2521854 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01021820001 6973483 6979816 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021820001 6973483 6979816 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021820001 6973483 6979816 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01037094001 29199121 29199682 GSVIVG01008985001 4062210 4068891 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01008985001 4062210 4068891 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01008985001 4062210 4068891 GO:0008272 sulfate transport The directed movement of sulfate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01008985001 4062210 4068891 GO:0008272 sulfate transport The directed movement of sulfate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01008985001 4062210 4068891 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01008985001 4062210 4068891 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01008985001 4062210 4068891 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01008985001 4062210 4068891 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01008985001 4062210 4068891 GO:0008272 sulfate transport The directed movement of sulfate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01008985001 4062210 4068891 GO:0008272 sulfate transport The directed movement of sulfate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01008985001 4062210 4068891 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01008985001 4062210 4068891 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01026752001 6239336 6239942 GSVIVG01025178001 3662217 3675769 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025178001 3662217 3675769 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01025178001 3662217 3675769 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. IEA GO:0008173 RNA methyltransferase activity GSVIVG01025178001 3662217 3675769 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01034916001 98421 99425 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01017913001 4607327 4607404 GSVIVG01031022001 21061028 21063664 GO:0009252 peptidoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031022001 21061028 21063664 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031022001 21061028 21063664 GO:0009252 peptidoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls. IEA Catalysis of the reaction: UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH + H+. IEA GO:0008762 UDP-N-acetylmuramate dehydrogenase activity GSVIVG01031022001 21061028 21063664 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH + H+. IEA GO:0008762 UDP-N-acetylmuramate dehydrogenase activity GSVIVG01031022001 21061028 21063664 GO:0009252 peptidoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031022001 21061028 21063664 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031022001 21061028 21063664 GO:0009252 peptidoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01031022001 21061028 21063664 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01009154001 5615061 5616841 GSVIVG01002911001 37210690 37216637 GSVIVG01010202001 17280659 17300963 GSVIVG01036648001 19770175 19777389 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01036648001 19770175 19777389 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01035848001 4842066 4842998 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01010459001 20776702 20776734 GSVIVG01030896001 18552579 18555814 GSVIVG01013449001 389002 390745 GSVIVG01019977001 12090746 12106439 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01035608001 2657661 2663256 GSVIVG01001441001 21037295 21052962 GSVIVG01025041001 5059884 5063476 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025041001 5059884 5063476 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025041001 5059884 5063476 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01025041001 5059884 5063476 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01025041001 5059884 5063476 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01025041001 5059884 5063476 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01015139001 1322449 1327421 GSVIVG01023603001 7853536 7879185 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01009733001 10847573 10849135 GSVIVG01000844001 2838942 2844199 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000844001 2838942 2844199 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000844001 2838942 2844199 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000844001 2838942 2844199 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01000844001 2838942 2844199 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01000844001 2838942 2844199 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01000844001 2838942 2844199 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01000844001 2838942 2844199 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01000844001 2838942 2844199 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01032758001 970374 991565 Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum. IEA GO:0003993 acid phosphatase activity GSVIVG01012136001 1121379 1125903 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012136001 1121379 1125903 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nucleotidyl group to a reactant. IEA GO:0016779 nucleotidyltransferase activity GSVIVG01000280001 20997206 21013872 GSVIVG01012467001 1267624 1277439 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function that links a sequence-specific transcription factor to the core RNA polymerase II complex but does not bind DNA itself. IEA GO:0003712 transcription cofactor activity GSVIVG01012467001 1267624 1277439 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01004485001 38827851 38829394 GSVIVG01037738001 7386093 7390777 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01037738001 7386093 7390777 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01037738001 7386093 7390777 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01037738001 7386093 7390777 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01037738001 7386093 7390777 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01037738001 7386093 7390777 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01037738001 7386093 7390777 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01037738001 7386093 7390777 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01037738001 7386093 7390777 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01037738001 7386093 7390777 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01037738001 7386093 7390777 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01037738001 7386093 7390777 GO:0051258 protein polymerization The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. IEA GO:0043234 protein complex Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01022377001 19305966 19326520 GSVIVG01031733001 3900266 3903031 GSVIVG01027394001 15304226 15312797 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GSVIVG01011407001 29407375 29409742 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01009521001 9032657 9038540 GSVIVG01032883001 23763889 23765688 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01032883001 23763889 23765688 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01005813001 22036288 22056011 GSVIVG01037740001 7399628 7400371 GO:0051260 protein homooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01037712001 7169435 7170792 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01037712001 7169435 7170792 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01037843001 7223775 7230300 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01037276001 16559508 16567307 GSVIVG01032735001 1186120 1192614 GSVIVG01024752001 7217812 7233598 GO:0007010 cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01008496001 1336725 1339729 GSVIVG01008750001 1698714 1706243 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01008750001 1698714 1706243 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01008750001 1698714 1706243 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033180 proton-transporting V-type ATPase, V1 domain A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01008750001 1698714 1706243 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01008750001 1698714 1706243 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01008750001 1698714 1706243 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033180 proton-transporting V-type ATPase, V1 domain A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01008750001 1698714 1706243 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01008750001 1698714 1706243 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01008750001 1698714 1706243 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0033180 proton-transporting V-type ATPase, V1 domain A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01008750001 1698714 1706243 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01008750001 1698714 1706243 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01008750001 1698714 1706243 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033180 proton-transporting V-type ATPase, V1 domain A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01008750001 1698714 1706243 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01008750001 1698714 1706243 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01008750001 1698714 1706243 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033180 proton-transporting V-type ATPase, V1 domain A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01008750001 1698714 1706243 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01008750001 1698714 1706243 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01008750001 1698714 1706243 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0033180 proton-transporting V-type ATPase, V1 domain A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01008750001 1698714 1706243 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01008750001 1698714 1706243 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01008750001 1698714 1706243 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033180 proton-transporting V-type ATPase, V1 domain A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01008750001 1698714 1706243 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01008750001 1698714 1706243 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01008750001 1698714 1706243 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033180 proton-transporting V-type ATPase, V1 domain A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01008750001 1698714 1706243 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01008750001 1698714 1706243 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01008750001 1698714 1706243 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0033180 proton-transporting V-type ATPase, V1 domain A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01006210001 23717392 23719157 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out); by a phosphorylative mechanism. IEA GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism GSVIVG01006210001 23717392 23719157 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out); by a phosphorylative mechanism. IEA GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism GSVIVG01006210001 23717392 23719157 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out); by a phosphorylative mechanism. IEA GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism GSVIVG01006210001 23717392 23719157 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out); by a phosphorylative mechanism. IEA GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism GSVIVG01006210001 23717392 23719157 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out); by a phosphorylative mechanism. IEA GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism GSVIVG01006210001 23717392 23719157 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out); by a phosphorylative mechanism. IEA GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism GSVIVG01006210001 23717392 23719157 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01006210001 23717392 23719157 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01006210001 23717392 23719157 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01006210001 23717392 23719157 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01006210001 23717392 23719157 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01006210001 23717392 23719157 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01006210001 23717392 23719157 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01006210001 23717392 23719157 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01006210001 23717392 23719157 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01006210001 23717392 23719157 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01006210001 23717392 23719157 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016469 proton-transporting two-sector ATPase complex A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01006210001 23717392 23719157 GO:0046034 ATP metabolic process The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01014741001 9113583 9114711 GSVIVG01034694001 7848253 7852765 GSVIVG01025614001 13562823 13568159 Catalysis of the removal of a phosphate group from phosphorylated myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol. IEA GO:0004437 inositol or phosphatidylinositol phosphatase activity GSVIVG01021263001 3139067 3149950 GSVIVG01012612001 17956 30631 GSVIVG01007373001 31580496 31580711 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01014223001 1640929 1644635 GSVIVG01018754001 20165291 20169686 GSVIVG01016941001 2800023 2801734 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01016941001 2800023 2801734 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01016941001 2800023 2801734 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010801001 22753527 22755877 GSVIVG01014958001 12924114 12928461 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01014958001 12924114 12928461 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01014958001 12924114 12928461 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01014958001 12924114 12928461 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01014958001 12924114 12928461 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01014958001 12924114 12928461 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01022031001 4091477 4096205 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01024945001 5838606 5853439 GSVIVG01000039001 2977898 2978891 GSVIVG01032028001 23372342 23397683 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01032028001 23372342 23397683 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: linoleate + O2 = (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate. IEA GO:0016165 lipoxygenase activity GSVIVG01032028001 23372342 23397683 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor. IEA GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen GSVIVG01032028001 23372342 23397683 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01029915001 1408690 1427359 GO:0032312 regulation of ARF GTPase activity Any process that modulates the activity of the GTPase ARF. IEA Increases the rate of GTP hydrolysis by the GTPase ARF. IEA GO:0008060 ARF GTPase activator activity GSVIVG01029915001 1408690 1427359 GO:0032312 regulation of ARF GTPase activity Any process that modulates the activity of the GTPase ARF. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01014785001 9695173 9706004 GSVIVG01035827001 4701759 4710455 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035827001 4701759 4710455 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035827001 4701759 4710455 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01035827001 4701759 4710455 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01035827001 4701759 4710455 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01035827001 4701759 4710455 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01031463001 18263826 18274434 GSVIVG01005679001 21173418 21174506 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01018329001 10945075 10978575 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004197 cysteine-type endopeptidase activity GSVIVG01021219001 2652801 2660280 GSVIVG01012306001 13241459 13249275 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012306001 13241459 13249275 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012306001 13241459 13249275 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01012306001 13241459 13249275 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01012306001 13241459 13249275 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01012306001 13241459 13249275 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01037872001 6871681 6872380 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA GSVIVG01036166001 19898332 19916261 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01036166001 19898332 19916261 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036166001 19898332 19916261 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01033394001 20986838 20994191 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033394001 20986838 20994191 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033394001 20986838 20994191 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033394001 20986838 20994191 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033394001 20986838 20994191 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01033394001 20986838 20994191 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01028162001 4315371 4317686 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA GSVIVG01028162001 4315371 4317686 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GSVIVG01032843001 317707 323620 GO:0016598 protein arginylation The posttranslational conjugation of arginine to the N-terminal aspartate or glutamate of a protein; required for the degradation of the protein via the ubiquitin pathway. IEA Catalysis of the reaction: L-arginyl-tRNA + protein = tRNA + L-arginyl-protein. IEA GO:0004057 arginyltransferase activity GSVIVG01015281001 2365783 2368523 GO:0007010 cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01015281001 2365783 2368523 GO:0030036 actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01032275001 14367713 14370007 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA GSVIVG01014507001 4614385 4614945 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014507001 4614385 4614945 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019915001 4431620 4434153 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01038579001 21743485 21744182 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01001303001 5164314 5166352 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001303001 5164314 5166352 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001303001 5164314 5166352 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001303001 5164314 5166352 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001303001 5164314 5166352 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001303001 5164314 5166352 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001303001 5164314 5166352 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+. IEA GO:0004459 L-lactate dehydrogenase activity GSVIVG01001303001 5164314 5166352 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+. IEA GO:0004459 L-lactate dehydrogenase activity GSVIVG01001303001 5164314 5166352 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+. IEA GO:0004459 L-lactate dehydrogenase activity GSVIVG01001303001 5164314 5166352 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+. IEA GO:0004459 L-lactate dehydrogenase activity GSVIVG01001303001 5164314 5166352 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+. IEA GO:0004459 L-lactate dehydrogenase activity GSVIVG01001303001 5164314 5166352 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+. IEA GO:0004459 L-lactate dehydrogenase activity GSVIVG01001303001 5164314 5166352 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01001303001 5164314 5166352 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01001303001 5164314 5166352 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01001303001 5164314 5166352 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01001303001 5164314 5166352 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01001303001 5164314 5166352 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01001303001 5164314 5166352 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01001303001 5164314 5166352 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01001303001 5164314 5166352 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01001303001 5164314 5166352 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01001303001 5164314 5166352 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01001303001 5164314 5166352 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01001303001 5164314 5166352 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001303001 5164314 5166352 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001303001 5164314 5166352 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001303001 5164314 5166352 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001303001 5164314 5166352 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001303001 5164314 5166352 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001303001 5164314 5166352 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01001303001 5164314 5166352 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01001303001 5164314 5166352 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01001303001 5164314 5166352 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01001303001 5164314 5166352 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01001303001 5164314 5166352 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01015567001 5013887 5017668 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01022072001 16347348 16362624 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01022072001 16347348 16362624 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038197001 24271160 24276761 GSVIVG01024608001 8458427 8471269 GSVIVG01011165001 7600688 7603471 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01023363001 19282904 19283347 GSVIVG01024778001 7023957 7025437 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01003166001 6038010 6059773 GO:0015746 citrate transport The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of arsenite from one side of a membrane to the other. IEA GO:0015105 arsenite transmembrane transporter activity GSVIVG01003166001 6038010 6059773 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of arsenite from one side of a membrane to the other. IEA GO:0015105 arsenite transmembrane transporter activity GSVIVG01003166001 6038010 6059773 GO:0015746 citrate transport The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, from one side of the membrane to the other. IEA GO:0015137 citrate transmembrane transporter activity GSVIVG01003166001 6038010 6059773 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, from one side of the membrane to the other. IEA GO:0015137 citrate transmembrane transporter activity GSVIVG01007603001 11371146 11380581 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01007603001 11371146 11380581 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01007603001 11371146 11380581 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01007603001 11371146 11380581 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01023927001 2442454 2443350 GSVIVG01008683001 1181544 1182422 GSVIVG01008325001 3235698 3236363 GSVIVG01020609001 3799202 3801066 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01021801001 7174981 7209963 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021801001 7174981 7209963 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021801001 7174981 7209963 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021801001 7174981 7209963 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021801001 7174981 7209963 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01021801001 7174981 7209963 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01021801001 7174981 7209963 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01021801001 7174981 7209963 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01021801001 7174981 7209963 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021801001 7174981 7209963 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021801001 7174981 7209963 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021801001 7174981 7209963 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021801001 7174981 7209963 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of calcium (Ca) ions from one side of a membrane to the other. IEA GO:0015085 calcium ion transmembrane transporter activity GSVIVG01021801001 7174981 7209963 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of calcium (Ca) ions from one side of a membrane to the other. IEA GO:0015085 calcium ion transmembrane transporter activity GSVIVG01021801001 7174981 7209963 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of calcium (Ca) ions from one side of a membrane to the other. IEA GO:0015085 calcium ion transmembrane transporter activity GSVIVG01021801001 7174981 7209963 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of calcium (Ca) ions from one side of a membrane to the other. IEA GO:0015085 calcium ion transmembrane transporter activity GSVIVG01021801001 7174981 7209963 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01021801001 7174981 7209963 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01021801001 7174981 7209963 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01021801001 7174981 7209963 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01021801001 7174981 7209963 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01021801001 7174981 7209963 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01021801001 7174981 7209963 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01021801001 7174981 7209963 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01005712001 21469908 21471504 GSVIVG01015078001 879771 883796 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004197 cysteine-type endopeptidase activity GSVIVG01015078001 879771 883796 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01015078001 879771 883796 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01015078001 879771 883796 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01011119001 1432217 1435639 GSVIVG01006226001 23770936 23778540 GSVIVG01010385001 20036450 20040327 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01014661001 8304202 8305387 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01014661001 8304202 8305387 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01014661001 8304202 8305387 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01014661001 8304202 8305387 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01014661001 8304202 8305387 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01014661001 8304202 8305387 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01014661001 8304202 8305387 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005267 potassium channel activity GSVIVG01014661001 8304202 8305387 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005267 potassium channel activity GSVIVG01014661001 8304202 8305387 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005267 potassium channel activity GSVIVG01014661001 8304202 8305387 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005267 potassium channel activity GSVIVG01014661001 8304202 8305387 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005267 potassium channel activity GSVIVG01014661001 8304202 8305387 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005267 potassium channel activity GSVIVG01014661001 8304202 8305387 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01014661001 8304202 8305387 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01014661001 8304202 8305387 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01014661001 8304202 8305387 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01014661001 8304202 8305387 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01014661001 8304202 8305387 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01029062001 11625680 11636150 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029062001 11625680 11636150 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01029062001 11625680 11636150 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01029062001 11625680 11636150 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01020591001 3972274 3972599 GSVIVG01022891001 18239802 18240218 GSVIVG01031823001 4708036 4709541 GSVIVG01037378001 14749273 14752814 GSVIVG01025250001 2704125 2707261 GSVIVG01017696001 2719817 2732762 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01017696001 2719817 2732762 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01017696001 2719817 2732762 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017696001 2719817 2732762 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017696001 2719817 2732762 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01017696001 2719817 2732762 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01017696001 2719817 2732762 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01017696001 2719817 2732762 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01017696001 2719817 2732762 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01017696001 2719817 2732762 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01027589001 15252766 15259081 GSVIVG01018994001 18001253 18005182 GSVIVG01019366001 277207 345809 GO:0008104 protein localization Any process by which a protein is transported to, or maintained in, a specific location. IEA GSVIVG01003694001 12265012 12270646 GSVIVG01007596001 11462814 11466176 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01007596001 11462814 11466176 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01007596001 11462814 11466176 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01014574001 5327583 5327979 GSVIVG01035650001 2989479 2992239 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035650001 2989479 2992239 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: D-arabinono-1,4-lactone + O2 = dehydro-D-arabinono-1,4-lactone + H2O2. IEA GO:0003885 D-arabinono-1,4-lactone oxidase activity GSVIVG01035650001 2989479 2992239 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01035650001 2989479 2992239 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01012919001 13468912 13471520 GSVIVG01028263001 5016696 5021533 GO:0006415 translational termination The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code). IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Involved in catalyzing the release of a nascent polypeptide chain from a ribosome. IEA GO:0003747 translation release factor activity GSVIVG01028263001 5016696 5021533 GO:0006415 translational termination The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code). IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA A translation release factor that is specific for one or more particular termination codons; acts at the ribosomal A-site and require polypeptidyl-tRNA at the P-site. IEA GO:0016149 translation release factor activity, codon specific GSVIVG01003183001 7655005 7660427 GSVIVG01012190001 688228 696254 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01012190001 688228 696254 Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01012190001 688228 696254 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01034414001 16606880 16610558 GSVIVG01000352001 11911754 11922553 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01000352001 11911754 11922553 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01000352001 11911754 11922553 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01004254001 37734070 37739476 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01004254001 37734070 37739476 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01004254001 37734070 37739476 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01004254001 37734070 37739476 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008112001 5684508 5694309 GSVIVG01003455001 10376529 10377349 GSVIVG01003595001 11080968 11087913 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin. IEA GO:0004221 ubiquitin thiolesterase activity GSVIVG01003595001 11080968 11087913 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01028123001 4007819 4010180 GSVIVG01026801001 7462152 7472209 GSVIVG01002097001 32913896 32918075 GSVIVG01013772001 7724620 7736183 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01034027001 15736246 15740259 GSVIVG01008768001 1811109 1814383 GSVIVG01017651001 2387834 2390890 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01017651001 2387834 2390890 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01017651001 2387834 2390890 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017651001 2387834 2390890 Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01015317001 2643524 2655505 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01034668001 7410958 7421594 GSVIVG01001507001 5297695 5298699 GO:0046907 intracellular transport The directed movement of substances within a cell. IEA GSVIVG01011017001 2184088 2186987 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01011017001 2184088 2186987 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01011017001 2184088 2186987 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01011017001 2184088 2186987 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01011017001 2184088 2186987 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01011017001 2184088 2186987 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01011017001 2184088 2186987 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01011017001 2184088 2186987 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01011017001 2184088 2186987 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01011017001 2184088 2186987 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01023933001 2380380 2384597 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01023933001 2380380 2384597 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01023933001 2380380 2384597 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01023933001 2380380 2384597 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01023933001 2380380 2384597 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01023933001 2380380 2384597 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01024446001 2651867 2694162 GO:0006306 DNA methylation The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01024446001 2651867 2694162 GO:0006306 DNA methylation The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01024446001 2651867 2694162 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01024446001 2651867 2694162 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01024446001 2651867 2694162 GO:0006306 DNA methylation The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Interacting selectively and non-covalently with chromatin, the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase. IEA GO:0003682 chromatin binding GSVIVG01024446001 2651867 2694162 GO:0006306 DNA methylation The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with chromatin, the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase. IEA GO:0003682 chromatin binding GSVIVG01024446001 2651867 2694162 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Interacting selectively and non-covalently with chromatin, the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase. IEA GO:0003682 chromatin binding GSVIVG01024446001 2651867 2694162 GO:0006333 chromatin assembly or disassembly The formation or destruction of chromatin structures. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with chromatin, the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase. IEA GO:0003682 chromatin binding GSVIVG01032734001 1196426 1198774 GO:0006571 tyrosine biosynthetic process The chemical reactions and pathways resulting in the formation of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032734001 1196426 1198774 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032734001 1196426 1198774 GO:0006571 tyrosine biosynthetic process The chemical reactions and pathways resulting in the formation of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid. IEA Catalysis of the reaction: prephenate + NADP+ = 4-hydroxyphenylpyruvate + CO2 + NADPH + H+. IEA GO:0004665 prephenate dehydrogenase (NADP+) activity GSVIVG01032734001 1196426 1198774 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: prephenate + NADP+ = 4-hydroxyphenylpyruvate + CO2 + NADPH + H+. IEA GO:0004665 prephenate dehydrogenase (NADP+) activity GSVIVG01032734001 1196426 1198774 GO:0006571 tyrosine biosynthetic process The chemical reactions and pathways resulting in the formation of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032734001 1196426 1198774 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026695001 4921490 4937187 GSVIVG01022682001 14717666 14717734 GSVIVG01010554001 16695695 16699914 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010554001 16695695 16699914 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010554001 16695695 16699914 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01010554001 16695695 16699914 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01010554001 16695695 16699914 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01010554001 16695695 16699914 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01014830001 10302482 10305368 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with transfer RNA. IEA GO:0000049 tRNA binding GSVIVG01014830001 10302482 10305368 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe). IEA GO:0004826 phenylalanine-tRNA ligase activity GSVIVG01014830001 10302482 10305368 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022460001 3269425 3269916 GSVIVG01028358001 6553661 6561134 GO:0006897 endocytosis A type of vesicle-mediated transport in which cells take up external materials or membrane constituents by the invagination of small region of the plasma membrane to form a new membrane-bounded vesicle. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01010647001 15633971 15650465 GSVIVG01034178001 14603030 14610047 GSVIVG01008296001 3531079 3538891 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01000048001 3072464 3074713 GSVIVG01029874001 882626 884825 GSVIVG01024382001 1798809 1811815 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01024382001 1798809 1811815 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01024382001 1798809 1811815 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01024382001 1798809 1811815 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007796001 8922764 8924925 GSVIVG01015494001 4194704 4202353 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01015494001 4194704 4202353 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01015494001 4194704 4202353 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01015494001 4194704 4202353 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012635001 236031 238074 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01012635001 236031 238074 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01012635001 236031 238074 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01012635001 236031 238074 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01012635001 236031 238074 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01012635001 236031 238074 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01012635001 236031 238074 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01012635001 236031 238074 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01033741001 18207485 18211069 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01022434001 2920747 2982993 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029833001 292795 293759 GSVIVG01012171001 793753 796574 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GSVIVG01015520001 4421113 4423879 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01015520001 4421113 4423879 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01015520001 4421113 4423879 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01015520001 4421113 4423879 GO:0042254 ribosome biogenesis The process of the formation of the constituents of the ribosome subunits, their assembly, and their transport to the sites of protein synthesis. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01015520001 4421113 4423879 GO:0042254 ribosome biogenesis The process of the formation of the constituents of the ribosome subunits, their assembly, and their transport to the sites of protein synthesis. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01015520001 4421113 4423879 GO:0042254 ribosome biogenesis The process of the formation of the constituents of the ribosome subunits, their assembly, and their transport to the sites of protein synthesis. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01018874001 19062452 19064462 GSVIVG01017154001 4763807 4809235 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019568001 1662924 1667111 GSVIVG01029442001 22849657 22861791 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function that links a sequence-specific transcription factor to the core RNA polymerase II complex but does not bind DNA itself. IEA GO:0003712 transcription cofactor activity GSVIVG01029442001 22849657 22861791 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone. IEA GO:0004402 histone acetyltransferase activity GSVIVG01029442001 22849657 22861791 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029442001 22849657 22861791 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01034967001 524037 525474 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01034967001 524037 525474 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01034967001 524037 525474 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01034967001 524037 525474 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01007211001 30877955 30892070 GSVIVG01016347001 4752811 4757492 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01016347001 4752811 4757492 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01016347001 4752811 4757492 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01016347001 4752811 4757492 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01008452001 1867713 1882977 GSVIVG01014271001 2206257 2219341 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01016059001 18152990 18153339 GSVIVG01002449001 34803347 34804041 GSVIVG01004787001 16102176 16127592 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01004787001 16102176 16127592 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01004787001 16102176 16127592 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01027707001 14044239 14045353 GSVIVG01013432001 514835 520024 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01013432001 514835 520024 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01013432001 514835 520024 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01013432001 514835 520024 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01013432001 514835 520024 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01013432001 514835 520024 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01037184001 28239146 28241275 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) The catalytic sector of the mitochondrial hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the mitochondrial inner membrane when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01037184001 28239146 28241275 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) The catalytic sector of the mitochondrial hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the mitochondrial inner membrane when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01034950001 378955 380758 GSVIVG01022143001 16919585 16924427 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01022143001 16919585 16924427 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01022143001 16919585 16924427 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01005971001 23039355 23041523 GSVIVG01017300001 6487805 6490633 GSVIVG01024229001 21966 83286 GSVIVG01037463001 13317787 13318885 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01027418001 16901822 16906858 GSVIVG01011227001 9835255 9835676 GSVIVG01022447001 3135506 3140682 GSVIVG01030047001 9122981 9126371 GSVIVG01037392001 14483804 14486970 GSVIVG01008832001 2573310 2584523 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01008832001 2573310 2584523 GO:0006284 base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01008832001 2573310 2584523 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008832001 2573310 2584523 GO:0006284 base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018794001 19796274 19802419 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01029484001 22355957 22356055 GSVIVG01005102001 18100548 18103474 GSVIVG01015332001 2760901 2763309 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01015332001 2760901 2763309 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01015332001 2760901 2763309 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01015332001 2760901 2763309 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01015332001 2760901 2763309 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01015332001 2760901 2763309 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01015332001 2760901 2763309 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01015332001 2760901 2763309 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01013249001 6219929 6269739 GSVIVG01008541001 992520 998342 Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum. IEA GO:0003993 acid phosphatase activity GSVIVG01008541001 992520 998342 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01008541001 992520 998342 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01012803001 23069352 23070356 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016471 vacuolar proton-transporting V-type ATPase complex A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01036633001 19507330 19508342 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01032183001 21759137 21774018 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032183001 21759137 21774018 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032183001 21759137 21774018 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032183001 21759137 21774018 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013550001 20613136 20614458 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion. IEA GO:0004806 triglyceride lipase activity GSVIVG01037896001 6551729 6559920 GSVIVG01007569001 11912232 11912950 GSVIVG01031486001 18028143 18029883 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01031486001 18028143 18029883 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01031486001 18028143 18029883 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01031486001 18028143 18029883 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01031486001 18028143 18029883 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01031486001 18028143 18029883 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01031486001 18028143 18029883 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01031486001 18028143 18029883 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01008140001 5434020 5452793 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01008140001 5434020 5452793 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01023990001 1897679 1903139 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01015200001 1774809 1783157 GSVIVG01011037001 2061399 2063976 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01020274001 22008383 22021510 GSVIVG01018917001 18658840 18666934 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01009337001 7533717 7536316 GSVIVG01036326001 3864341 3865343 Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01036326001 3864341 3865343 Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01028595001 10377157 10377285 GSVIVG01007990001 6871145 6878292 GO:0006464 protein modification process The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01017118001 4318262 4323119 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01017118001 4318262 4323119 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01017118001 4318262 4323119 GO:0008272 sulfate transport The directed movement of sulfate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01017118001 4318262 4323119 GO:0008272 sulfate transport The directed movement of sulfate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01017118001 4318262 4323119 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01017118001 4318262 4323119 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01017118001 4318262 4323119 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01017118001 4318262 4323119 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01017118001 4318262 4323119 GO:0008272 sulfate transport The directed movement of sulfate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01017118001 4318262 4323119 GO:0008272 sulfate transport The directed movement of sulfate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01017118001 4318262 4323119 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01017118001 4318262 4323119 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0008271 secondary active sulfate transmembrane transporter activity GSVIVG01026881001 19673023 19675581 GSVIVG01025280001 2480964 2492191 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025280001 2480964 2492191 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01013641001 2043267 2043530 GSVIVG01013581001 21181514 21182849 GSVIVG01005924001 886169 898284 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01005924001 886169 898284 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01005924001 886169 898284 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01005924001 886169 898284 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019912001 4413957 4418111 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01009816001 11515519 11519895 GSVIVG01032665001 1671489 1678965 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032665001 1671489 1678965 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032665001 1671489 1678965 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032665001 1671489 1678965 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032665001 1671489 1678965 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032665001 1671489 1678965 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032665001 1671489 1678965 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032665001 1671489 1678965 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032665001 1671489 1678965 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032665001 1671489 1678965 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032665001 1671489 1678965 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+. IEA GO:0004367 glycerol-3-phosphate dehydrogenase (NAD+) activity GSVIVG01032665001 1671489 1678965 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+. IEA GO:0004367 glycerol-3-phosphate dehydrogenase (NAD+) activity GSVIVG01032665001 1671489 1678965 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+. IEA GO:0004367 glycerol-3-phosphate dehydrogenase (NAD+) activity GSVIVG01032665001 1671489 1678965 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+. IEA GO:0004367 glycerol-3-phosphate dehydrogenase (NAD+) activity GSVIVG01032665001 1671489 1678965 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+. IEA GO:0004367 glycerol-3-phosphate dehydrogenase (NAD+) activity GSVIVG01032665001 1671489 1678965 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+. IEA GO:0004367 glycerol-3-phosphate dehydrogenase (NAD+) activity GSVIVG01032665001 1671489 1678965 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+. IEA GO:0004367 glycerol-3-phosphate dehydrogenase (NAD+) activity GSVIVG01032665001 1671489 1678965 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+. IEA GO:0004367 glycerol-3-phosphate dehydrogenase (NAD+) activity GSVIVG01032665001 1671489 1678965 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+. IEA GO:0004367 glycerol-3-phosphate dehydrogenase (NAD+) activity GSVIVG01032665001 1671489 1678965 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+. IEA GO:0004367 glycerol-3-phosphate dehydrogenase (NAD+) activity GSVIVG01032665001 1671489 1678965 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032665001 1671489 1678965 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032665001 1671489 1678965 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032665001 1671489 1678965 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032665001 1671489 1678965 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032665001 1671489 1678965 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032665001 1671489 1678965 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032665001 1671489 1678965 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032665001 1671489 1678965 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032665001 1671489 1678965 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032665001 1671489 1678965 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01032665001 1671489 1678965 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01032665001 1671489 1678965 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01032665001 1671489 1678965 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01032665001 1671489 1678965 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01032665001 1671489 1678965 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01032665001 1671489 1678965 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01032665001 1671489 1678965 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01032665001 1671489 1678965 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01032665001 1671489 1678965 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01032665001 1671489 1678965 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GSVIVG01032665001 1671489 1678965 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GSVIVG01032665001 1671489 1678965 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GSVIVG01032665001 1671489 1678965 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GSVIVG01032665001 1671489 1678965 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GSVIVG01032665001 1671489 1678965 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GSVIVG01032665001 1671489 1678965 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GSVIVG01032665001 1671489 1678965 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GSVIVG01032665001 1671489 1678965 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GSVIVG01032665001 1671489 1678965 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GSVIVG01032665001 1671489 1678965 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01032665001 1671489 1678965 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01032665001 1671489 1678965 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01032665001 1671489 1678965 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01032665001 1671489 1678965 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01032665001 1671489 1678965 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01032665001 1671489 1678965 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01032665001 1671489 1678965 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01032665001 1671489 1678965 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01032665001 1671489 1678965 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01032665001 1671489 1678965 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01032665001 1671489 1678965 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01032665001 1671489 1678965 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01032665001 1671489 1678965 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01032665001 1671489 1678965 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01032665001 1671489 1678965 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01032665001 1671489 1678965 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01032665001 1671489 1678965 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01032665001 1671489 1678965 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01032665001 1671489 1678965 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01032665001 1671489 1678965 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01032665001 1671489 1678965 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01032665001 1671489 1678965 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01032665001 1671489 1678965 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01032665001 1671489 1678965 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01032665001 1671489 1678965 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01032665001 1671489 1678965 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01032665001 1671489 1678965 GO:0046168 glycerol-3-phosphate catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01032665001 1671489 1678965 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01032665001 1671489 1678965 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01005166001 18895423 18900074 GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01005166001 18895423 18900074 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01005166001 18895423 18900074 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01005166001 18895423 18900074 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01005166001 18895423 18900074 GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004197 cysteine-type endopeptidase activity GSVIVG01005166001 18895423 18900074 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004197 cysteine-type endopeptidase activity GSVIVG01005166001 18895423 18900074 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004197 cysteine-type endopeptidase activity GSVIVG01005166001 18895423 18900074 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004197 cysteine-type endopeptidase activity GSVIVG01005166001 18895423 18900074 GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. IEA Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+. IEA GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity GSVIVG01005166001 18895423 18900074 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+. IEA GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity GSVIVG01005166001 18895423 18900074 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+. IEA GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity GSVIVG01005166001 18895423 18900074 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+. IEA GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity GSVIVG01005166001 18895423 18900074 GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01005166001 18895423 18900074 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01005166001 18895423 18900074 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01005166001 18895423 18900074 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01005166001 18895423 18900074 GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01005166001 18895423 18900074 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01005166001 18895423 18900074 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01005166001 18895423 18900074 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01005166001 18895423 18900074 GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01005166001 18895423 18900074 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01005166001 18895423 18900074 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01005166001 18895423 18900074 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016879001 2205746 2225094 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016879001 2205746 2225094 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016879001 2205746 2225094 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016879001 2205746 2225094 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01016879001 2205746 2225094 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01016879001 2205746 2225094 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01016879001 2205746 2225094 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01016879001 2205746 2225094 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01016879001 2205746 2225094 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01016879001 2205746 2225094 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016879001 2205746 2225094 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016879001 2205746 2225094 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016879001 2205746 2225094 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01016879001 2205746 2225094 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01016879001 2205746 2225094 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01016879001 2205746 2225094 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01016879001 2205746 2225094 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01016879001 2205746 2225094 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01016879001 2205746 2225094 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01016879001 2205746 2225094 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01016879001 2205746 2225094 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01029556001 21631215 21637266 GO:0001522 pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01029556001 21631215 21637266 GO:0009451 RNA modification The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01029556001 21631215 21637266 GO:0001522 pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs. IEA Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. IEA GO:0009982 pseudouridine synthase activity GSVIVG01029556001 21631215 21637266 GO:0009451 RNA modification The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. IEA Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. IEA GO:0009982 pseudouridine synthase activity GSVIVG01008343001 3094096 3100458 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01008343001 3094096 3100458 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008343001 3094096 3100458 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01012742001 1165899 1176476 GO:0016226 iron-sulfur cluster assembly The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017196001 5216635 5238081 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01017196001 5216635 5238081 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017196001 5216635 5238081 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01017196001 5216635 5238081 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01001426001 19023718 19026944 GSVIVG01028153001 4252840 4259442 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01028153001 4252840 4259442 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01028153001 4252840 4259442 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01028153001 4252840 4259442 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028153001 4252840 4259442 Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01028153001 4252840 4259442 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01027171001 17264900 17281034 GSVIVG01016851001 1954538 1959088 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01037305001 16116719 16117698 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01020969001 16199276 16222697 GSVIVG01010911001 15814713 15816027 GSVIVG01008571001 797555 799083 GSVIVG01012011001 2202688 2225478 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033162001 8709993 8711285 GSVIVG01014249001 1996597 2012013 GSVIVG01036290001 3420423 3434120 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01036290001 3420423 3434120 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01036290001 3420423 3434120 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01036290001 3420423 3434120 GO:0009067 aspartate family amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01036290001 3420423 3434120 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01036290001 3420423 3434120 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the reaction: ATP + L-aspartate = ADP + 4-phospho-L-aspartate. IEA GO:0004072 aspartate kinase activity GSVIVG01036290001 3420423 3434120 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: ATP + L-aspartate = ADP + 4-phospho-L-aspartate. IEA GO:0004072 aspartate kinase activity GSVIVG01036290001 3420423 3434120 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the reaction: ATP + L-aspartate = ADP + 4-phospho-L-aspartate. IEA GO:0004072 aspartate kinase activity GSVIVG01036290001 3420423 3434120 GO:0009067 aspartate family amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine. IEA Catalysis of the reaction: ATP + L-aspartate = ADP + 4-phospho-L-aspartate. IEA GO:0004072 aspartate kinase activity GSVIVG01036290001 3420423 3434120 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: ATP + L-aspartate = ADP + 4-phospho-L-aspartate. IEA GO:0004072 aspartate kinase activity GSVIVG01036290001 3420423 3434120 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the reaction: L-homoserine + NADP+ = L-aspartate-4-semialdehyde + NADPH + H+. IEA GO:0004412 homoserine dehydrogenase activity GSVIVG01036290001 3420423 3434120 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: L-homoserine + NADP+ = L-aspartate-4-semialdehyde + NADPH + H+. IEA GO:0004412 homoserine dehydrogenase activity GSVIVG01036290001 3420423 3434120 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the reaction: L-homoserine + NADP+ = L-aspartate-4-semialdehyde + NADPH + H+. IEA GO:0004412 homoserine dehydrogenase activity GSVIVG01036290001 3420423 3434120 GO:0009067 aspartate family amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine. IEA Catalysis of the reaction: L-homoserine + NADP+ = L-aspartate-4-semialdehyde + NADPH + H+. IEA GO:0004412 homoserine dehydrogenase activity GSVIVG01036290001 3420423 3434120 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: L-homoserine + NADP+ = L-aspartate-4-semialdehyde + NADPH + H+. IEA GO:0004412 homoserine dehydrogenase activity GSVIVG01036290001 3420423 3434120 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01036290001 3420423 3434120 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01036290001 3420423 3434120 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01036290001 3420423 3434120 GO:0009067 aspartate family amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01036290001 3420423 3434120 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01036290001 3420423 3434120 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01036290001 3420423 3434120 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01036290001 3420423 3434120 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01036290001 3420423 3434120 GO:0009067 aspartate family amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01036290001 3420423 3434120 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01036290001 3420423 3434120 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. IEA GO:0016597 amino acid binding GSVIVG01036290001 3420423 3434120 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. IEA GO:0016597 amino acid binding GSVIVG01036290001 3420423 3434120 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. IEA GO:0016597 amino acid binding GSVIVG01036290001 3420423 3434120 GO:0009067 aspartate family amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine. IEA Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. IEA GO:0016597 amino acid binding GSVIVG01036290001 3420423 3434120 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. IEA GO:0016597 amino acid binding GSVIVG01036290001 3420423 3434120 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01036290001 3420423 3434120 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01036290001 3420423 3434120 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01036290001 3420423 3434120 GO:0009067 aspartate family amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01036290001 3420423 3434120 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01036290001 3420423 3434120 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01036290001 3420423 3434120 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01036290001 3420423 3434120 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01036290001 3420423 3434120 GO:0009067 aspartate family amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01036290001 3420423 3434120 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01033365001 21190543 21194230 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01033365001 21190543 21194230 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01033365001 21190543 21194230 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01033365001 21190543 21194230 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01024165001 661991 664840 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01024165001 661991 664840 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01024165001 661991 664840 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and carries out proton transport across a membrane. The proton-transporting domain (F0, V0, or A0) includes integral and peripheral membrane proteins. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01024165001 661991 664840 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0033179 proton-transporting V-type ATPase, V0 domain A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01024165001 661991 664840 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01024165001 661991 664840 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01024165001 661991 664840 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and carries out proton transport across a membrane. The proton-transporting domain (F0, V0, or A0) includes integral and peripheral membrane proteins. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01024165001 661991 664840 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033179 proton-transporting V-type ATPase, V0 domain A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01024165001 661991 664840 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01024165001 661991 664840 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01024165001 661991 664840 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and carries out proton transport across a membrane. The proton-transporting domain (F0, V0, or A0) includes integral and peripheral membrane proteins. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01024165001 661991 664840 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033179 proton-transporting V-type ATPase, V0 domain A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01024165001 661991 664840 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01024165001 661991 664840 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01024165001 661991 664840 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and carries out proton transport across a membrane. The proton-transporting domain (F0, V0, or A0) includes integral and peripheral membrane proteins. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01024165001 661991 664840 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0033179 proton-transporting V-type ATPase, V0 domain A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01014320001 2605401 2606252 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01014320001 2605401 2606252 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01016063001 18239371 18241591 GSVIVG01012666001 433319 450223 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01023880001 2751841 2755856 GSVIVG01001936001 14997435 14998259 GSVIVG01011577001 6298552 6305704 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022511001 4211075 4215049 GSVIVG01030543001 6608795 6613564 GSVIVG01003201001 7830578 7832041 GO:0009765 photosynthesis, light harvesting Absorption and transfer of the energy absorbed from light photons between photosystem reaction centers. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01005049001 17691079 17693340 GO:0006730 one-carbon metabolic process The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. IEA Catalysis of the reaction: H2CO3 = CO2 + H2O. IEA GO:0004089 carbonate dehydratase activity GSVIVG01005049001 17691079 17693340 GO:0006730 one-carbon metabolic process The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01029195001 18691088 18697551 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01029195001 18691088 18697551 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01029195001 18691088 18697551 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01029195001 18691088 18697551 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01029195001 18691088 18697551 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01029195001 18691088 18697551 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01029195001 18691088 18697551 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01029195001 18691088 18697551 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01029195001 18691088 18697551 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01029195001 18691088 18697551 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01029195001 18691088 18697551 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01029195001 18691088 18697551 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01029195001 18691088 18697551 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01029195001 18691088 18697551 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01029195001 18691088 18697551 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01029195001 18691088 18697551 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01029195001 18691088 18697551 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01029195001 18691088 18697551 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01029195001 18691088 18697551 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01029195001 18691088 18697551 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01029195001 18691088 18697551 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01029195001 18691088 18697551 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01029195001 18691088 18697551 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01029195001 18691088 18697551 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01029195001 18691088 18697551 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01029195001 18691088 18697551 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01029195001 18691088 18697551 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01029195001 18691088 18697551 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01029195001 18691088 18697551 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01029195001 18691088 18697551 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01018539001 13649384 13651094 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018539001 13649384 13651094 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018539001 13649384 13651094 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018539001 13649384 13651094 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01018539001 13649384 13651094 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01018539001 13649384 13651094 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01022246001 17810781 17812713 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01022246001 17810781 17812713 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01022246001 17810781 17812713 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01022246001 17810781 17812713 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01022246001 17810781 17812713 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01022246001 17810781 17812713 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01022246001 17810781 17812713 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01022246001 17810781 17812713 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01022246001 17810781 17812713 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01022246001 17810781 17812713 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01022246001 17810781 17812713 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01022246001 17810781 17812713 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01022246001 17810781 17812713 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01022246001 17810781 17812713 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01022246001 17810781 17812713 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01022246001 17810781 17812713 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01022246001 17810781 17812713 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01022246001 17810781 17812713 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01022246001 17810781 17812713 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022246001 17810781 17812713 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022246001 17810781 17812713 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022246001 17810781 17812713 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022246001 17810781 17812713 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022246001 17810781 17812713 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022246001 17810781 17812713 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01022246001 17810781 17812713 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01022246001 17810781 17812713 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01022246001 17810781 17812713 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01022246001 17810781 17812713 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01022246001 17810781 17812713 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01009283001 6947874 6949301 GO:0009396 folic acid and derivative biosynthetic process The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01034186001 14574284 14576270 GSVIVG01008734001 1536671 1544403 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008734001 1536671 1544403 GO:0046470 phosphatidylcholine metabolic process The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008734001 1536671 1544403 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate. IEA GO:0004630 phospholipase D activity GSVIVG01008734001 1536671 1544403 GO:0046470 phosphatidylcholine metabolic process The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate. IEA GO:0004630 phospholipase D activity GSVIVG01008734001 1536671 1544403 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01008734001 1536671 1544403 GO:0046470 phosphatidylcholine metabolic process The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01036748001 23036858 23037511 GO:0006278 RNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01036748001 23036858 23037511 GO:0006278 RNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01036748001 23036858 23037511 GO:0006278 RNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. IEA Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time. IEA GO:0003964 RNA-directed DNA polymerase activity GSVIVG01010124001 15895365 15897710 GSVIVG01008423001 2254244 2255631 GSVIVG01024861001 6391674 6393170 GSVIVG01025045001 5035948 5037167 GSVIVG01029540001 21824891 21840485 GSVIVG01021128001 1695978 1704736 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01021128001 1695978 1704736 GO:0009725 response to hormone stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01021128001 1695978 1704736 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01033725001 18315486 18325154 GSVIVG01036369001 4306109 4307716 GSVIVG01009472001 8645812 8672088 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01009472001 8645812 8672088 GO:0022904 respiratory electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01009472001 8645812 8672088 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01009472001 8645812 8672088 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01009472001 8645812 8672088 GO:0022904 respiratory electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01009472001 8645812 8672088 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01015410001 3367198 3378311 GSVIVG01008454001 1848500 1853570 GSVIVG01001650001 21782446 21784602 GSVIVG01009994001 13231125 13232440 GSVIVG01037173001 28331841 28332170 GSVIVG01024421001 2366462 2378109 Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01026956001 19038935 19043670 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01014896001 11363440 11365290 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01014896001 11363440 11365290 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01014896001 11363440 11365290 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01014896001 11363440 11365290 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01017248001 5886625 5887577 GSVIVG01024122001 915998 917711 GSVIVG01022621001 13526997 13528253 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01022621001 13526997 13528253 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025497001 311448 317888 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025497001 311448 317888 GO:0006367 transcription initiation from RNA polymerase II promoter A transcription initiation process that results in RNA synthesis by RNA polymerase II. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025497001 311448 317888 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Functions to initiate or regulate RNA polymerase II transcription. IEA GO:0003702 RNA polymerase II transcription factor activity GSVIVG01025497001 311448 317888 GO:0006367 transcription initiation from RNA polymerase II promoter A transcription initiation process that results in RNA synthesis by RNA polymerase II. IEA Functions to initiate or regulate RNA polymerase II transcription. IEA GO:0003702 RNA polymerase II transcription factor activity GSVIVG01025497001 311448 317888 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025497001 311448 317888 GO:0006367 transcription initiation from RNA polymerase II promoter A transcription initiation process that results in RNA synthesis by RNA polymerase II. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01010292001 19145958 19153266 Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01010986001 2407113 2428442 GSVIVG01037670001 6715872 6719385 GO:0009245 lipid A biosynthetic process The chemical reactions and pathways resulting in the formation of lipid A, the glycolipid moiety of bacterial lipopolysaccharides, consisting of six fatty acyl chains linked to two glucosamine residues. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037670001 6715872 6719385 GO:0009245 lipid A biosynthetic process The chemical reactions and pathways resulting in the formation of lipid A, the glycolipid moiety of bacterial lipopolysaccharides, consisting of six fatty acyl chains linked to two glucosamine residues. IEA Catalysis of the reaction: ATP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-(beta-D-1,6)-2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl beta-phosphate = ADP + 2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-glucosamine 1,4'-bisphosphate. IEA GO:0009029 tetraacyldisaccharide 4'-kinase activity GSVIVG01006263001 24158064 24198466 GSVIVG01026067001 25024973 25037565 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01026067001 25024973 25037565 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01021908001 5742214 5774387 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01013693001 2716543 2718537 GSVIVG01028871001 17937132 17940515 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01028871001 17937132 17940515 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01014613001 5716880 5720662 GSVIVG01033643001 19001766 19007541 GSVIVG01038035001 16570451 16572001 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. IEA GO:0004364 glutathione transferase activity GSVIVG01027865001 8773786 8779227 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016873001 2154282 2158605 GSVIVG01027246001 17662339 17673587 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027246001 17662339 17673587 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027246001 17662339 17673587 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027246001 17662339 17673587 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027246001 17662339 17673587 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01027246001 17662339 17673587 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01008389001 2565056 2565658 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008389001 2565056 2565658 GO:0008299 isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008389001 2565056 2565658 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA. IEA GO:0004421 hydroxymethylglutaryl-CoA synthase activity GSVIVG01008389001 2565056 2565658 GO:0008299 isoprenoid biosynthetic process The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. IEA Catalysis of the reaction: acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA. IEA GO:0004421 hydroxymethylglutaryl-CoA synthase activity GSVIVG01035107001 1516565 1526361 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor. IEA GO:0003995 acyl-CoA dehydrogenase activity GSVIVG01035107001 1516565 1526361 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor. IEA GO:0003995 acyl-CoA dehydrogenase activity GSVIVG01035107001 1516565 1526361 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor. IEA GO:0003995 acyl-CoA dehydrogenase activity GSVIVG01035107001 1516565 1526361 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01035107001 1516565 1526361 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01035107001 1516565 1526361 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01035107001 1516565 1526361 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035107001 1516565 1526361 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035107001 1516565 1526361 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035107001 1516565 1526361 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01035107001 1516565 1526361 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01035107001 1516565 1526361 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01035107001 1516565 1526361 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GSVIVG01035107001 1516565 1526361 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GSVIVG01035107001 1516565 1526361 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GSVIVG01035107001 1516565 1526361 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01035107001 1516565 1526361 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01035107001 1516565 1526361 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01004706001 15381562 15400149 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01004706001 15381562 15400149 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01004706001 15381562 15400149 GO:0006421 asparaginyl-tRNA aminoacylation The process of coupling asparagine to asparaginyl-tRNA, catalyzed by asparaginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01004706001 15381562 15400149 GO:0006422 aspartyl-tRNA aminoacylation The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01004706001 15381562 15400149 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01004706001 15381562 15400149 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01004706001 15381562 15400149 GO:0006421 asparaginyl-tRNA aminoacylation The process of coupling asparagine to asparaginyl-tRNA, catalyzed by asparaginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01004706001 15381562 15400149 GO:0006422 aspartyl-tRNA aminoacylation The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01004706001 15381562 15400149 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01004706001 15381562 15400149 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01004706001 15381562 15400149 GO:0006421 asparaginyl-tRNA aminoacylation The process of coupling asparagine to asparaginyl-tRNA, catalyzed by asparaginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01004706001 15381562 15400149 GO:0006422 aspartyl-tRNA aminoacylation The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01004706001 15381562 15400149 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp). IEA GO:0004815 aspartate-tRNA ligase activity GSVIVG01004706001 15381562 15400149 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp). IEA GO:0004815 aspartate-tRNA ligase activity GSVIVG01004706001 15381562 15400149 GO:0006421 asparaginyl-tRNA aminoacylation The process of coupling asparagine to asparaginyl-tRNA, catalyzed by asparaginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp). IEA GO:0004815 aspartate-tRNA ligase activity GSVIVG01004706001 15381562 15400149 GO:0006422 aspartyl-tRNA aminoacylation The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp). IEA GO:0004815 aspartate-tRNA ligase activity GSVIVG01004706001 15381562 15400149 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn). IEA GO:0004816 asparagine-tRNA ligase activity GSVIVG01004706001 15381562 15400149 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn). IEA GO:0004816 asparagine-tRNA ligase activity GSVIVG01004706001 15381562 15400149 GO:0006421 asparaginyl-tRNA aminoacylation The process of coupling asparagine to asparaginyl-tRNA, catalyzed by asparaginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn). IEA GO:0004816 asparagine-tRNA ligase activity GSVIVG01004706001 15381562 15400149 GO:0006422 aspartyl-tRNA aminoacylation The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn). IEA GO:0004816 asparagine-tRNA ligase activity GSVIVG01004706001 15381562 15400149 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01004706001 15381562 15400149 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01004706001 15381562 15400149 GO:0006421 asparaginyl-tRNA aminoacylation The process of coupling asparagine to asparaginyl-tRNA, catalyzed by asparaginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01004706001 15381562 15400149 GO:0006422 aspartyl-tRNA aminoacylation The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010958001 2649541 2655851 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of potassium ions (K+) from one side of a membrane to the other. IEA GO:0015079 potassium ion transmembrane transporter activity GSVIVG01009016001 4306814 4310127 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GSVIVG01016598001 2519393 2521518 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01036528001 23082774 23084766 GSVIVG01008814001 2406173 2411495 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01008814001 2406173 2411495 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01008814001 2406173 2411495 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009160001 5652915 5653524 GSVIVG01016606001 2464480 2465412 GSVIVG01007892001 7856334 7862567 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01003255001 8376575 8387962 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01003255001 8376575 8387962 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01003255001 8376575 8387962 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01003255001 8376575 8387962 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01003255001 8376575 8387962 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01003255001 8376575 8387962 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01003255001 8376575 8387962 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01003255001 8376575 8387962 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01034474001 20741429 20743521 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01034474001 20741429 20743521 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01034474001 20741429 20743521 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01034474001 20741429 20743521 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01027416001 16912286 16914210 GSVIVG01018690001 11063176 11063657 GSVIVG01031897001 5237935 5238870 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01034087001 15277500 15279911 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01034087001 15277500 15279911 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01034087001 15277500 15279911 GO:0007596 blood coagulation The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01034087001 15277500 15279911 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01034087001 15277500 15279911 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01034087001 15277500 15279911 GO:0007596 blood coagulation The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01034087001 15277500 15279911 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034087001 15277500 15279911 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034087001 15277500 15279911 GO:0007596 blood coagulation The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034087001 15277500 15279911 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01034087001 15277500 15279911 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01034087001 15277500 15279911 GO:0007596 blood coagulation The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01031760001 4130582 4162043 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031760001 4130582 4162043 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031760001 4130582 4162043 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031760001 4130582 4162043 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01031760001 4130582 4162043 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01031760001 4130582 4162043 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01031760001 4130582 4162043 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031760001 4130582 4162043 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031760001 4130582 4162043 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031760001 4130582 4162043 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01031760001 4130582 4162043 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01031760001 4130582 4162043 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01031760001 4130582 4162043 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01031760001 4130582 4162043 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01031760001 4130582 4162043 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01031760001 4130582 4162043 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031760001 4130582 4162043 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031760001 4130582 4162043 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01018960001 18329572 18348704 Modulates the rate of GTP hydrolysis by a small monomeric GTPase. IEA GO:0005083 small GTPase regulator activity GSVIVG01018960001 18329572 18348704 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01037676001 6765149 6778665 GSVIVG01010387001 20057175 20057597 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01014663001 8329805 8330017 GSVIVG01007449001 32005254 32005858 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GSVIVG01015305001 2521015 2527145 Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor). IEA GO:0016763 transferase activity, transferring pentosyl groups GSVIVG01017429001 8427059 8439527 GSVIVG01035652001 3022802 3030621 GSVIVG01020910001 17395112 17395321 GSVIVG01032320001 15046693 15047752 GSVIVG01001812001 26015212 26015550 GSVIVG01012155001 984735 987272 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01012155001 984735 987272 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01012155001 984735 987272 GO:0015886 heme transport The directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01012155001 984735 987272 GO:0017004 cytochrome complex assembly The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01012155001 984735 987272 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01012155001 984735 987272 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells. IEA GO:0015232 heme transporter activity GSVIVG01012155001 984735 987272 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells. IEA GO:0015232 heme transporter activity GSVIVG01012155001 984735 987272 GO:0015886 heme transport The directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells. IEA GO:0015232 heme transporter activity GSVIVG01012155001 984735 987272 GO:0017004 cytochrome complex assembly The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells. IEA GO:0015232 heme transporter activity GSVIVG01012155001 984735 987272 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of, within or between cells. IEA GO:0015232 heme transporter activity GSVIVG01035477001 1588078 1591208 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01035477001 1588078 1591208 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01023096001 15372758 15377350 GSVIVG01010396001 20151792 20151842 GSVIVG01014672001 8443447 8455090 GSVIVG01031347001 157424 164408 GSVIVG01022103001 16601210 16602203 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01022103001 16601210 16602203 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01022103001 16601210 16602203 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01005103001 18133775 18136228 GSVIVG01022044001 3822080 3838624 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013149001 7559107 7561555 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01001910001 7133574 7136313 GSVIVG01021240001 2894729 2902709 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01021240001 2894729 2902709 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01021240001 2894729 2902709 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01021240001 2894729 2902709 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01021240001 2894729 2902709 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031302001 532220 532516 GSVIVG01008468001 1679826 1685710 GO:0008612 peptidyl-lysine modification to hypusine The posttranslational modification of peptidyl-lysine to form hypusine, N6-(4-amino-2-hydroxybutyl)-L-lysine. IEA GSVIVG01003473001 10576470 10586327 GSVIVG01020967001 16236928 16240362 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025237001 2854568 2862140 GSVIVG01008499001 1314626 1323288 GSVIVG01035611001 2681349 2685591 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01035611001 2681349 2685591 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01035611001 2681349 2685591 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01035611001 2681349 2685591 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035611001 2681349 2685591 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008837001 2627885 2629132 GSVIVG01015900001 19070427 19072521 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019102001 16743165 16744762 GSVIVG01010495001 21055709 21063369 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01011467001 29856617 29867241 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01011467001 29856617 29867241 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01011467001 29856617 29867241 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01011467001 29856617 29867241 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01011467001 29856617 29867241 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01011467001 29856617 29867241 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01011467001 29856617 29867241 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Catalysis of the reaction: 4 ATP + 2 phosphorylase b = 4 ADP + phosphorylase a. IEA GO:0004689 phosphorylase kinase activity GSVIVG01011467001 29856617 29867241 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Catalysis of the reaction: 4 ATP + 2 phosphorylase b = 4 ADP + phosphorylase a. IEA GO:0004689 phosphorylase kinase activity GSVIVG01011467001 29856617 29867241 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01011467001 29856617 29867241 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01011467001 29856617 29867241 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. IEA GO:0005516 calmodulin binding GSVIVG01011467001 29856617 29867241 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. IEA GO:0005516 calmodulin binding GSVIVG01011467001 29856617 29867241 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011467001 29856617 29867241 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009005001 4204993 4213214 GSVIVG01027368001 15625581 15637899 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01027368001 15625581 15637899 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01027368001 15625581 15637899 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01027368001 15625581 15637899 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01010064001 14534080 14534298 GSVIVG01024920001 6020208 6022458 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01024920001 6020208 6022458 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01018538001 13659143 13662826 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018538001 13659143 13662826 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018538001 13659143 13662826 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018538001 13659143 13662826 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01018538001 13659143 13662826 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01018538001 13659143 13662826 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01021555001 6983376 7024143 GSVIVG01033121001 7856758 7897638 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01033121001 7856758 7897638 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01033121001 7856758 7897638 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01033121001 7856758 7897638 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01033121001 7856758 7897638 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01033121001 7856758 7897638 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity. IEA GO:0004872 receptor activity GSVIVG01033121001 7856758 7897638 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033121001 7856758 7897638 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033121001 7856758 7897638 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033121001 7856758 7897638 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033121001 7856758 7897638 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033121001 7856758 7897638 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033121001 7856758 7897638 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033121001 7856758 7897638 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033121001 7856758 7897638 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033121001 7856758 7897638 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033121001 7856758 7897638 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033121001 7856758 7897638 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033121001 7856758 7897638 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01033121001 7856758 7897638 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01033121001 7856758 7897638 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01033121001 7856758 7897638 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01033121001 7856758 7897638 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01033121001 7856758 7897638 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01033121001 7856758 7897638 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01033121001 7856758 7897638 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01033121001 7856758 7897638 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01033121001 7856758 7897638 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01033121001 7856758 7897638 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01033121001 7856758 7897638 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01025851001 11217900 11220263 GSVIVG01009640001 10119990 10120448 GSVIVG01016247001 5932893 5937022 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016247001 5932893 5937022 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reversible transfer of a 2-carbon ketol group (CH2OH-CO-) from a ketose phosphate donor to an aldose phosphate acceptor. IEA GO:0004802 transketolase activity GSVIVG01027720001 7094697 7095305 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01029930001 1625669 1627010 GSVIVG01038299001 12406263 12407990 GSVIVG01030546001 6624408 6627687 Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. IEA GO:0008171 O-methyltransferase activity GSVIVG01028024001 3258526 3262727 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the repair of a photoproduct resulting from ultraviolet irradiation of two adjacent pyrimidine residues in DNA. IEA GO:0003913 DNA photolyase activity GSVIVG01037280001 16509986 16512843 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030561001 6759331 6760440 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029519001 22025446 22025587 GSVIVG01009540001 9178747 9183975 GSVIVG01032340001 15281117 15292426 GSVIVG01027804001 7967258 7969061 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01027804001 7967258 7969061 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01027804001 7967258 7969061 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01027804001 7967258 7969061 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01027804001 7967258 7969061 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01027804001 7967258 7969061 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01027804001 7967258 7969061 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Catalysis of the reaction: 4 ATP + 2 phosphorylase b = 4 ADP + phosphorylase a. IEA GO:0004689 phosphorylase kinase activity GSVIVG01027804001 7967258 7969061 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Catalysis of the reaction: 4 ATP + 2 phosphorylase b = 4 ADP + phosphorylase a. IEA GO:0004689 phosphorylase kinase activity GSVIVG01027804001 7967258 7969061 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01027804001 7967258 7969061 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01027804001 7967258 7969061 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01027804001 7967258 7969061 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01027804001 7967258 7969061 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. IEA GO:0005516 calmodulin binding GSVIVG01027804001 7967258 7969061 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. IEA GO:0005516 calmodulin binding GSVIVG01027804001 7967258 7969061 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027804001 7967258 7969061 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011988001 2383591 2384528 GSVIVG01029263001 17849676 17869267 GSVIVG01030893001 18470149 18478393 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01030893001 18470149 18478393 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01030893001 18470149 18478393 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01030893001 18470149 18478393 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01030893001 18470149 18478393 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01030893001 18470149 18478393 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01030893001 18470149 18478393 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030893001 18470149 18478393 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030893001 18470149 18478393 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030893001 18470149 18478393 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030893001 18470149 18478393 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030893001 18470149 18478393 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030893001 18470149 18478393 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01030893001 18470149 18478393 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01030893001 18470149 18478393 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01030893001 18470149 18478393 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01030893001 18470149 18478393 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01030893001 18470149 18478393 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01030893001 18470149 18478393 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. IEA GO:0016881 acid-amino acid ligase activity GSVIVG01030893001 18470149 18478393 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. IEA GO:0016881 acid-amino acid ligase activity GSVIVG01030893001 18470149 18478393 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. IEA GO:0016881 acid-amino acid ligase activity GSVIVG01030893001 18470149 18478393 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. IEA GO:0016881 acid-amino acid ligase activity GSVIVG01030893001 18470149 18478393 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. IEA GO:0016881 acid-amino acid ligase activity GSVIVG01030893001 18470149 18478393 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. IEA GO:0016881 acid-amino acid ligase activity GSVIVG01030893001 18470149 18478393 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01030893001 18470149 18478393 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01030893001 18470149 18478393 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01030893001 18470149 18478393 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01030893001 18470149 18478393 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01030893001 18470149 18478393 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01005250001 19836012 19841056 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced pteridine and one other donor, and one atom of oxygen is incorporated into one donor. IEA GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen GSVIVG01038117001 23590739 23600976 GO:0000272 polysaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01038117001 23590739 23600976 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01038117001 23590739 23600976 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01038117001 23590739 23600976 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01038117001 23590739 23600976 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01038117001 23590739 23600976 GO:0000272 polysaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages. IEA Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA GO:0008061 chitin binding GSVIVG01038117001 23590739 23600976 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA GO:0008061 chitin binding GSVIVG01038117001 23590739 23600976 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA GO:0008061 chitin binding GSVIVG01038117001 23590739 23600976 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA GO:0008061 chitin binding GSVIVG01038117001 23590739 23600976 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA GO:0008061 chitin binding GSVIVG01038117001 23590739 23600976 GO:0000272 polysaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01038117001 23590739 23600976 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01038117001 23590739 23600976 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01038117001 23590739 23600976 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01038117001 23590739 23600976 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01038117001 23590739 23600976 GO:0000272 polysaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01038117001 23590739 23600976 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01038117001 23590739 23600976 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01038117001 23590739 23600976 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01038117001 23590739 23600976 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01006342001 340057 344422 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01006342001 340057 344422 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01006581001 26634981 26635780 GSVIVG01005836001 22155651 22160476 GO:0006790 sulfur metabolic process The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione. IEA Catalysis of the removal of a phosphate group from phosphorylated myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol. IEA GO:0004437 inositol or phosphatidylinositol phosphatase activity GSVIVG01005836001 22155651 22160476 GO:0006790 sulfur metabolic process The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione. IEA Catalysis of the reaction: adenosine 3',5'-bisphosphate + H2O = adenosine 5'-phosphate + phosphate. IEA GO:0008441 3'(2'),5'-bisphosphate nucleotidase activity GSVIVG01009714001 10698778 10701640 GSVIVG01005167001 18904096 18905610 GSVIVG01037272001 16641855 16645390 GSVIVG01031063001 21611704 21612117 GSVIVG01025241001 2788884 2808373 GSVIVG01015559001 4917286 4918302 Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01015559001 4917286 4918302 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01020279001 21954863 21962081 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01005269001 20049082 20050043 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01005269001 20049082 20050043 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023595001 7760323 7761763 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01030016001 8943743 8946035 GSVIVG01025439001 798666 801358 GSVIVG01037671001 6719843 6720919 GSVIVG01000315001 2999773 3004686 GO:0032968 positive regulation of RNA elongation from RNA polymerase II promoter Any process that activates or increases the frequency, rate or extent of RNA elongation, the extension of an RNA molecule after transcription initiation by the addition of ribonucleotides, catalyzed by RNA polymerase II. IEA Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule following transcription initiation. IEA GO:0003711 transcription elongation regulator activity GSVIVG01013392001 749852 760246 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01036393001 4570171 4575902 GSVIVG01009977001 12985919 12989790 GSVIVG01030603001 7078502 7079509 GSVIVG01000500001 15094001 15094805 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01038636001 21297786 21301549 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01038636001 21297786 21301549 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01038636001 21297786 21301549 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01018246001 12594790 12602918 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01001067001 7242791 7244218 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01011845001 3678832 3683638 GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA GSVIVG01025551001 14111050 14113960 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: 2 H2O2 = O2 + 2 H2O. IEA GO:0004096 catalase activity GSVIVG01025551001 14111050 14113960 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2 H2O2 = O2 + 2 H2O. IEA GO:0004096 catalase activity GSVIVG01025551001 14111050 14113960 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01025551001 14111050 14113960 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01025551001 14111050 14113960 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01025551001 14111050 14113960 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01025551001 14111050 14113960 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025551001 14111050 14113960 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025551001 14111050 14113960 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01025551001 14111050 14113960 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01025551001 14111050 14113960 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01025551001 14111050 14113960 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01024242001 140769 143178 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01024242001 140769 143178 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01024242001 140769 143178 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01024242001 140769 143178 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01038268001 24820454 24828348 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Prevents the dissociation of GDP from the small GTPase Rab, thereby preventing GTP from binding. IEA GO:0005093 Rab GDP-dissociation inhibitor activity GSVIVG01038268001 24820454 24828348 GO:0043087 regulation of GTPase activity Any process that modulates the rate of GTP hydrolysis by a GTPase. IEA Prevents the dissociation of GDP from the small GTPase Rab, thereby preventing GTP from binding. IEA GO:0005093 Rab GDP-dissociation inhibitor activity GSVIVG01003266001 8632468 8634827 GSVIVG01022131001 16821786 16824038 GSVIVG01025635001 13435573 13441098 GSVIVG01022069001 16332009 16337060 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01022069001 16332009 16337060 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01003552001 14564087 14573121 GSVIVG01011938001 2879352 2882182 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01011938001 2879352 2882182 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01028771001 19005966 19006693 GSVIVG01025437001 803373 803826 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of hydroxylation at the 7-methyl group of chlorophyllide a, according to the reactions: chlorophyllide a + O2 + NADPH + H+ = 7-hydroxychlorophyllide a + H2O + NADP+ and 7-hydroxychlorophyllide a + O2 + NADPH + H+ = chlorophyllide b + 2 H2O + NADP+. IEA GO:0010277 chlorophyllide a oxygenase activity GSVIVG01022921001 18022235 18024629 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024212001 205526 209603 Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum. IEA GO:0003993 acid phosphatase activity GSVIVG01024212001 205526 209603 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01024212001 205526 209603 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01027636001 14806704 14808739 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016673001 277672 278791 GSVIVG01024442001 2625988 2626809 GSVIVG01034391001 16920686 16921000 GSVIVG01038356001 13473090 13479891 GSVIVG01026547001 21979116 21981077 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01026547001 21979116 21981077 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01026547001 21979116 21981077 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01026547001 21979116 21981077 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01026547001 21979116 21981077 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01026547001 21979116 21981077 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01026547001 21979116 21981077 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026547001 21979116 21981077 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026547001 21979116 21981077 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01026547001 21979116 21981077 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01012377001 263489 270134 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule following transcription initiation. IEA GO:0003711 transcription elongation regulator activity GSVIVG01012377001 263489 270134 GO:0006357 regulation of transcription from RNA polymerase II promoter Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. IEA Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule following transcription initiation. IEA GO:0003711 transcription elongation regulator activity GSVIVG01012377001 263489 270134 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01012377001 263489 270134 GO:0006357 regulation of transcription from RNA polymerase II promoter Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01012377001 263489 270134 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01012377001 263489 270134 GO:0006357 regulation of transcription from RNA polymerase II promoter Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01023921001 2465510 2466922 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01004718001 15488850 15490852 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01013702001 2799135 2807105 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01013702001 2799135 2807105 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01013702001 2799135 2807105 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01013702001 2799135 2807105 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013702001 2799135 2807105 Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01013702001 2799135 2807105 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01011022001 2148897 2150483 GO:0006364 rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. IEA GO:0005730 nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. IEA GSVIVG01021187001 2410061 2424286 GSVIVG01015311001 2574483 2579633 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015311001 2574483 2579633 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015311001 2574483 2579633 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015311001 2574483 2579633 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate. IEA GO:0004470 malic enzyme activity GSVIVG01015311001 2574483 2579633 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate. IEA GO:0004470 malic enzyme activity GSVIVG01015311001 2574483 2579633 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate. IEA GO:0004470 malic enzyme activity GSVIVG01015311001 2574483 2579633 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: (S)-malate + NADP+ = pyruvate + CO2 + NADPH + H+. Also decarboxylates oxaloacetate. IEA GO:0004473 malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity GSVIVG01015311001 2574483 2579633 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: (S)-malate + NADP+ = pyruvate + CO2 + NADPH + H+. Also decarboxylates oxaloacetate. IEA GO:0004473 malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity GSVIVG01015311001 2574483 2579633 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: (S)-malate + NADP+ = pyruvate + CO2 + NADPH + H+. Also decarboxylates oxaloacetate. IEA GO:0004473 malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity GSVIVG01015311001 2574483 2579633 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01015311001 2574483 2579633 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01015311001 2574483 2579633 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01015311001 2574483 2579633 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01015311001 2574483 2579633 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01015311001 2574483 2579633 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01015311001 2574483 2579633 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01015311001 2574483 2579633 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01015311001 2574483 2579633 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01015311001 2574483 2579633 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01015311001 2574483 2579633 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01015311001 2574483 2579633 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01015311001 2574483 2579633 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01015311001 2574483 2579633 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01015311001 2574483 2579633 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01011366001 28994751 29010176 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01011366001 28994751 29010176 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01015672001 15321428 15321811 GSVIVG01003766001 12505400 12507250 GSVIVG01026474001 22980323 22981237 GSVIVG01008577001 751113 752057 GSVIVG01017299001 6477259 6485682 GO:0006465 signal peptide processing The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01017299001 6477259 6485682 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01032985001 24823031 24826025 GSVIVG01024607001 8478430 8480726 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01033650001 18921028 18924155 GO:0006835 dicarboxylic acid transport The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). IEA GO:0017153 sodium:dicarboxylate symporter activity GSVIVG01001500001 5174168 5174658 GSVIVG01037535001 11907053 11907782 GSVIVG01000516001 13537627 13538059 GSVIVG01029129001 19310450 19313103 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01012562001 3653669 3659783 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012562001 3653669 3659783 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01008515001 1201558 1215948 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01008515001 1201558 1215948 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01007429001 31793894 31799683 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0008236 serine-type peptidase activity GSVIVG01023093001 15446912 15447178 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other. IEA GO:0005337 nucleoside transmembrane transporter activity GSVIVG01009304001 7151908 7153160 GSVIVG01032251001 13984914 13992724 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01032251001 13984914 13992724 GO:0009725 response to hormone stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01032251001 13984914 13992724 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01032251001 13984914 13992724 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01032251001 13984914 13992724 GO:0009725 response to hormone stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01032251001 13984914 13992724 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01027464001 16525577 16531271 GSVIVG01026124001 24251670 24260656 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01026124001 24251670 24260656 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01026124001 24251670 24260656 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01026124001 24251670 24260656 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01026124001 24251670 24260656 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037479001 12971411 12975980 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01037479001 12971411 12975980 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of the reaction: 2 L-ascorbate + O2 = 2 dehydroascorbate + 2 H2O. IEA GO:0008447 L-ascorbate oxidase activity GSVIVG01037479001 12971411 12975980 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01015394001 3251962 3254889 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01015394001 3251962 3254889 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01015394001 3251962 3254889 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01015394001 3251962 3254889 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01015394001 3251962 3254889 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01015394001 3251962 3254889 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01015394001 3251962 3254889 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01015394001 3251962 3254889 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01015394001 3251962 3254889 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01015394001 3251962 3254889 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015394001 3251962 3254889 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015394001 3251962 3254889 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015394001 3251962 3254889 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01015394001 3251962 3254889 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01015394001 3251962 3254889 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01036916001 17687721 17713368 GSVIVG01029160001 19011106 19012414 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01029160001 19011106 19012414 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01029160001 19011106 19012414 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01029160001 19011106 19012414 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01029160001 19011106 19012414 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01029160001 19011106 19012414 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01029160001 19011106 19012414 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01029160001 19011106 19012414 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01035700001 3439924 3441644 GSVIVG01003215001 13976631 13980385 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01003215001 13976631 13980385 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01037116001 28984713 28986077 GSVIVG01020630001 3657308 3658704 Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. IEA GO:0008171 O-methyltransferase activity GSVIVG01027035001 18441281 18446658 GSVIVG01000050001 3077529 3090848 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01000050001 3077529 3090848 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01000050001 3077529 3090848 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01000050001 3077529 3090848 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Catalysis of the reaction: 4 ATP + 2 phosphorylase b = 4 ADP + phosphorylase a. IEA GO:0004689 phosphorylase kinase activity GSVIVG01000050001 3077529 3090848 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Catalysis of the reaction: 4 ATP + 2 phosphorylase b = 4 ADP + phosphorylase a. IEA GO:0004689 phosphorylase kinase activity GSVIVG01000050001 3077529 3090848 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Catalysis of the reaction: 4 ATP + 2 phosphorylase b = 4 ADP + phosphorylase a. IEA GO:0004689 phosphorylase kinase activity GSVIVG01000050001 3077529 3090848 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. IEA GO:0005516 calmodulin binding GSVIVG01000050001 3077529 3090848 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. IEA GO:0005516 calmodulin binding GSVIVG01000050001 3077529 3090848 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. IEA GO:0005516 calmodulin binding GSVIVG01000050001 3077529 3090848 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000050001 3077529 3090848 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000050001 3077529 3090848 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005964 phosphorylase kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016032001 17630973 17631296 GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA GSVIVG01025327001 1989871 1994275 GSVIVG01008655001 71718 73739 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01034273001 13925705 13926356 GSVIVG01024226001 6506 7685 GO:0006904 vesicle docking involved in exocytosis The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis. IEA GSVIVG01024226001 6506 7685 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GSVIVG01036602001 19050129 19050884 GSVIVG01001863001 162431 173208 GO:0000272 polysaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001863001 162431 173208 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001863001 162431 173208 GO:0000272 polysaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages. IEA Catalysis of the hydrolysis of 1,4-alpha-glucosidic linkages in polysaccharides so as to remove successive maltose units from the non-reducing ends of the chains. IEA GO:0016161 beta-amylase activity GSVIVG01001863001 162431 173208 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of 1,4-alpha-glucosidic linkages in polysaccharides so as to remove successive maltose units from the non-reducing ends of the chains. IEA GO:0016161 beta-amylase activity GSVIVG01001863001 162431 173208 GO:0000272 polysaccharide catabolic process The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01001863001 162431 173208 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01016219001 6413422 6487142 GO:0006904 vesicle docking involved in exocytosis The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis. IEA GO:0000145 exocyst A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals. IEA GSVIVG01016219001 6413422 6487142 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0000145 exocyst A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals. IEA GSVIVG01028790001 18768337 18777529 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01028790001 18768337 18777529 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028790001 18768337 18777529 Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01028790001 18768337 18777529 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01031915001 5351364 5352546 GSVIVG01013164001 7322917 7339488 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01013164001 7322917 7339488 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013164001 7322917 7339488 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01010803001 22774641 22779289 GSVIVG01022176001 17219628 17225466 GSVIVG01004417001 38509563 38511491 GSVIVG01015276001 2341323 2343064 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01002527001 35197610 35203240 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019626001 2064381 2070248 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01011520001 13229560 13231569 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017996001 5347965 5350466 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01017996001 5347965 5350466 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01028386001 6902315 6938769 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: phosphatidylcholine + a sterol = a sterol ester + 1-acylglycerophosphocholine. IEA GO:0004607 phosphatidylcholine-sterol O-acyltransferase activity GSVIVG01001381001 24109038 24111844 GSVIVG01016564001 2740552 2749848 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016564001 2740552 2749848 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01029168001 18975176 18980194 GSVIVG01027374001 15566045 15567976 GSVIVG01015950001 16055584 16055901 GSVIVG01012633001 229674 230733 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01009659001 10260453 10262103 GO:0016559 peroxisome fission The division of a mature peroxisome within a cell to form two or more separate peroxisome compartments. IEA GO:0005778 peroxisomal membrane The lipid bilayer surrounding a peroxisome. IEA GSVIVG01033345001 21331640 21338086 GSVIVG01035004001 832978 835192 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA GSVIVG01020693001 3067379 3068478 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004197 cysteine-type endopeptidase activity GSVIVG01020693001 3067379 3068478 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01004790001 12465 13764 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01004790001 12465 13764 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001643001 21692918 21694501 GSVIVG01014514001 4700623 4702489 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01014514001 4700623 4702489 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01030066001 9427619 9430359 GSVIVG01026319001 13640930 13649842 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01016248001 5930034 5932833 GSVIVG01035644001 2935959 2937695 GO:0009116 nucleoside metabolic process The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine). IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01014432001 3676945 3687513 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01031125001 1920620 1924241 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020848001 1111493 1114850 GSVIVG01033852001 17237406 17239762 GO:0006730 one-carbon metabolic process The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. IEA Catalysis of the reaction: H2CO3 = CO2 + H2O. IEA GO:0004089 carbonate dehydratase activity GSVIVG01033852001 17237406 17239762 GO:0006730 one-carbon metabolic process The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01033852001 17237406 17239762 GO:0006730 one-carbon metabolic process The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01025583001 13891619 13899168 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025583001 13891619 13899168 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025583001 13891619 13899168 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025583001 13891619 13899168 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025583001 13891619 13899168 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025583001 13891619 13899168 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025583001 13891619 13899168 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025583001 13891619 13899168 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025583001 13891619 13899168 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01025583001 13891619 13899168 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01025583001 13891619 13899168 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01025583001 13891619 13899168 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01025583001 13891619 13899168 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01025583001 13891619 13899168 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01025583001 13891619 13899168 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01025583001 13891619 13899168 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). IEA GO:0005388 calcium-transporting ATPase activity GSVIVG01025583001 13891619 13899168 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025583001 13891619 13899168 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025583001 13891619 13899168 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025583001 13891619 13899168 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025583001 13891619 13899168 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025583001 13891619 13899168 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025583001 13891619 13899168 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025583001 13891619 13899168 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025583001 13891619 13899168 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01025583001 13891619 13899168 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01025583001 13891619 13899168 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01025583001 13891619 13899168 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01025583001 13891619 13899168 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01025583001 13891619 13899168 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01025583001 13891619 13899168 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01025583001 13891619 13899168 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01025583001 13891619 13899168 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01025583001 13891619 13899168 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01025583001 13891619 13899168 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01025583001 13891619 13899168 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01025583001 13891619 13899168 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01025583001 13891619 13899168 GO:0006816 calcium ion transport The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01025583001 13891619 13899168 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01025583001 13891619 13899168 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01036136001 20274137 20300288 GSVIVG01027397001 17087207 17089432 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01027397001 17087207 17089432 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027397001 17087207 17089432 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01024775001 7057170 7061114 GSVIVG01036760001 22905487 22906558 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01002710001 35955987 35956178 GSVIVG01001168001 1096084 1114915 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01001168001 1096084 1114915 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01001168001 1096084 1114915 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01001168001 1096084 1114915 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01001168001 1096084 1114915 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01001168001 1096084 1114915 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01001168001 1096084 1114915 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01001168001 1096084 1114915 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01001168001 1096084 1114915 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01001168001 1096084 1114915 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01031875001 5037283 5039660 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01031875001 5037283 5039660 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01031875001 5037283 5039660 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01031875001 5037283 5039660 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01031371001 19451312 19457543 GSVIVG01010342001 19639325 19647921 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01010342001 19639325 19647921 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01010342001 19639325 19647921 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01010342001 19639325 19647921 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01010342001 19639325 19647921 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01010342001 19639325 19647921 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01010342001 19639325 19647921 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010342001 19639325 19647921 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010342001 19639325 19647921 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01010342001 19639325 19647921 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01010342001 19639325 19647921 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate in the presence of single- or double-stranded DNA; drives another reaction. IEA GO:0008094 DNA-dependent ATPase activity GSVIVG01010342001 19639325 19647921 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate in the presence of single- or double-stranded DNA; drives another reaction. IEA GO:0008094 DNA-dependent ATPase activity GSVIVG01026661001 4459788 4466466 GSVIVG01017001001 3362926 3368211 GSVIVG01005682001 21227721 21232273 GSVIVG01035917001 5775821 5780538 GSVIVG01035869001 5066719 5067795 GSVIVG01035929001 6044778 6059248 GSVIVG01009499001 8874255 8878074 GSVIVG01013736001 8065297 8071309 GO:0015976 carbon utilization A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbon sources and then activates genes to scavenge the last traces of the primary carbon source and to transport and metabolize alternative carbon sources such as carbon dioxide or carbonic acid. The utilization process begins when the cell or organism detects carbon levels, includes the activation of genes whose products detect, transport or metabolize carbon-containing substances, and ends when carbon is incorporated into the cell or organism's metabolism. IEA Catalysis of the reaction: H2CO3 = CO2 + H2O. IEA GO:0004089 carbonate dehydratase activity GSVIVG01013736001 8065297 8071309 GO:0015976 carbon utilization A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbon sources and then activates genes to scavenge the last traces of the primary carbon source and to transport and metabolize alternative carbon sources such as carbon dioxide or carbonic acid. The utilization process begins when the cell or organism detects carbon levels, includes the activation of genes whose products detect, transport or metabolize carbon-containing substances, and ends when carbon is incorporated into the cell or organism's metabolism. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01014387001 3289702 3292924 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001638001 21635292 21635735 GSVIVG01005164001 18880274 18882054 GSVIVG01028525001 9209042 9219025 GSVIVG01033540001 19873175 19874681 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033540001 19873175 19874681 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01033540001 19873175 19874681 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01015208001 1841979 1844868 GSVIVG01025181001 3639901 3646935 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025181001 3639901 3646935 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA helix. IEA GO:0003678 DNA helicase activity GSVIVG01025181001 3639901 3646935 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01025181001 3639901 3646935 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01025181001 3639901 3646935 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025181001 3639901 3646935 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01021964001 5014253 5015240 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01021964001 5014253 5015240 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01004751001 15948754 15949053 GSVIVG01027792001 7797395 7797916 GSVIVG01016834001 1769570 1772627 GSVIVG01022990001 17238016 17266288 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01022990001 17238016 17266288 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01002607001 35411707 35413952 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01002607001 35411707 35413952 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01002607001 35411707 35413952 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01002607001 35411707 35413952 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01036759001 22906565 22924143 GSVIVG01029778001 14525716 14560210 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01029778001 14525716 14560210 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01029778001 14525716 14560210 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01029778001 14525716 14560210 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01018585001 12842196 12843677 GSVIVG01032639001 1939189 1954420 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. IEA GO:0004364 glutathione transferase activity GSVIVG01032628001 2057440 2059353 GSVIVG01025937001 27006644 27007560 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01025937001 27006644 27007560 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024669001 7928545 7929679 GSVIVG01033607001 19354671 19363393 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033607001 19354671 19363393 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01033607001 19354671 19363393 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01000750001 362439 365586 GSVIVG01019901001 4339352 4356199 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01019901001 4339352 4356199 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01019901001 4339352 4356199 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01019901001 4339352 4356199 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01016509001 3298345 3300371 GSVIVG01003121001 7440832 7448130 GSVIVG01001852001 26310627 26314057 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0000159 protein phosphatase type 2A complex A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit. IEA Modulation of the activity of the enzyme protein phosphatase type 2A. IEA GO:0008601 protein phosphatase type 2A regulator activity GSVIVG01016790001 1383359 1390899 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01024434001 2513506 2515019 GSVIVG01012729001 1060924 1063119 GSVIVG01022775001 16404254 16408500 GSVIVG01036815001 17367997 17396611 GSVIVG01032957001 24606619 24610211 GSVIVG01006666001 27323498 27325104 GSVIVG01020661001 3341974 3345838 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01013468001 178837 216959 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01013468001 178837 216959 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01013468001 178837 216959 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01013468001 178837 216959 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01013468001 178837 216959 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01021482001 6010506 6013524 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018941001 18515917 18518002 GO:0030071 regulation of mitotic metaphase/anaphase transition Any process that modulates the frequency, rate or extent of the onset of anaphase (chromosome movement) in the mitotic cell cycle. IEA GO:0005680 anaphase-promoting complex A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01027413001 16919195 16921692 GO:0009416 response to light stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01027413001 16919195 16921692 GO:0009416 response to light stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030376001 5098648 5100915 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01004840001 5573344 5579529 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01007708001 10124363 10160031 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01002204001 204800 206635 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA GSVIVG01015952001 16094219 16096253 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01015952001 16094219 16096253 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01003271001 8647286 8647956 GSVIVG01019279001 2097842 2102620 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GSVIVG01026873001 19730102 19731944 GSVIVG01008313001 3351114 3351628 GSVIVG01022191001 17320621 17323012 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01022191001 17320621 17323012 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01003275001 8651809 8652307 GSVIVG01016856001 2027678 2032205 GO:0006066 alcohol metabolic process The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GSVIVG01016856001 2027678 2032205 GO:0006066 alcohol metabolic process The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01033163001 8723150 8739489 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01033163001 8723150 8739489 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01033163001 8723150 8739489 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01033163001 8723150 8739489 GO:0006940 regulation of smooth muscle contraction Any process that modulates the frequency, rate or extent of smooth muscle contraction. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01033163001 8723150 8739489 GO:0006940 regulation of smooth muscle contraction Any process that modulates the frequency, rate or extent of smooth muscle contraction. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01033163001 8723150 8739489 GO:0006940 regulation of smooth muscle contraction Any process that modulates the frequency, rate or extent of smooth muscle contraction. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01033163001 8723150 8739489 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01033163001 8723150 8739489 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01033163001 8723150 8739489 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. IEA GO:0004930 G-protein coupled receptor activity GSVIVG01033163001 8723150 8739489 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033163001 8723150 8739489 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033163001 8723150 8739489 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033163001 8723150 8739489 GO:0006940 regulation of smooth muscle contraction Any process that modulates the frequency, rate or extent of smooth muscle contraction. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033163001 8723150 8739489 GO:0006940 regulation of smooth muscle contraction Any process that modulates the frequency, rate or extent of smooth muscle contraction. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033163001 8723150 8739489 GO:0006940 regulation of smooth muscle contraction Any process that modulates the frequency, rate or extent of smooth muscle contraction. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033163001 8723150 8739489 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033163001 8723150 8739489 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033163001 8723150 8739489 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033163001 8723150 8739489 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033163001 8723150 8739489 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033163001 8723150 8739489 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033163001 8723150 8739489 GO:0006940 regulation of smooth muscle contraction Any process that modulates the frequency, rate or extent of smooth muscle contraction. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033163001 8723150 8739489 GO:0006940 regulation of smooth muscle contraction Any process that modulates the frequency, rate or extent of smooth muscle contraction. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033163001 8723150 8739489 GO:0006940 regulation of smooth muscle contraction Any process that modulates the frequency, rate or extent of smooth muscle contraction. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033163001 8723150 8739489 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033163001 8723150 8739489 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033163001 8723150 8739489 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033163001 8723150 8739489 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01033163001 8723150 8739489 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01033163001 8723150 8739489 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01033163001 8723150 8739489 GO:0006940 regulation of smooth muscle contraction Any process that modulates the frequency, rate or extent of smooth muscle contraction. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01033163001 8723150 8739489 GO:0006940 regulation of smooth muscle contraction Any process that modulates the frequency, rate or extent of smooth muscle contraction. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01033163001 8723150 8739489 GO:0006940 regulation of smooth muscle contraction Any process that modulates the frequency, rate or extent of smooth muscle contraction. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01033163001 8723150 8739489 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01033163001 8723150 8739489 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01033163001 8723150 8739489 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01030658001 13094060 13094266 GSVIVG01003702001 15246114 15252150 GSVIVG01035332001 550826 552210 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01001669001 14116297 14117427 GSVIVG01014304001 2504140 2508208 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01014304001 2504140 2508208 GO:0006631 fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01014304001 2504140 2508208 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01014304001 2504140 2508208 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01014304001 2504140 2508208 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+. IEA GO:0004367 glycerol-3-phosphate dehydrogenase (NAD+) activity GSVIVG01014304001 2504140 2508208 GO:0006631 fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+. IEA GO:0004367 glycerol-3-phosphate dehydrogenase (NAD+) activity GSVIVG01014304001 2504140 2508208 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+. IEA GO:0004367 glycerol-3-phosphate dehydrogenase (NAD+) activity GSVIVG01014304001 2504140 2508208 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+. IEA GO:0004367 glycerol-3-phosphate dehydrogenase (NAD+) activity GSVIVG01014304001 2504140 2508208 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor. IEA GO:0004368 glycerol-3-phosphate dehydrogenase activity GSVIVG01014304001 2504140 2508208 GO:0006631 fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor. IEA GO:0004368 glycerol-3-phosphate dehydrogenase activity GSVIVG01014304001 2504140 2508208 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor. IEA GO:0004368 glycerol-3-phosphate dehydrogenase activity GSVIVG01014304001 2504140 2508208 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor. IEA GO:0004368 glycerol-3-phosphate dehydrogenase activity GSVIVG01014304001 2504140 2508208 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01014304001 2504140 2508208 GO:0006631 fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01014304001 2504140 2508208 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01014304001 2504140 2508208 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01014304001 2504140 2508208 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01014304001 2504140 2508208 GO:0006631 fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01014304001 2504140 2508208 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01014304001 2504140 2508208 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01014304001 2504140 2508208 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01014304001 2504140 2508208 GO:0006631 fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01014304001 2504140 2508208 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01014304001 2504140 2508208 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01030396001 5208593 5211497 GO:0051090 regulation of transcription factor activity Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Functions to initiate or regulate RNA polymerase II transcription. IEA GO:0003702 RNA polymerase II transcription factor activity GSVIVG01030396001 5208593 5211497 GO:0051090 regulation of transcription factor activity Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA IEA GO:0016986 transcription initiation factor activity GSVIVG01017062001 3881259 3885649 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01023234001 20831269 20837054 GSVIVG01009174001 5743183 5751624 GSVIVG01034490001 20473466 20492229 GSVIVG01021920001 5563100 5565424 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01021920001 5563100 5565424 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01021920001 5563100 5565424 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01021920001 5563100 5565424 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01021920001 5563100 5565424 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021920001 5563100 5565424 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021920001 5563100 5565424 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01021920001 5563100 5565424 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01028976001 16962310 16964099 GSVIVG01013976001 8271851 8351138 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031521001 17702534 17706419 GSVIVG01030052001 9260509 9268596 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029244001 18105021 18111422 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01029244001 18105021 18111422 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01029244001 18105021 18111422 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01029244001 18105021 18111422 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01029244001 18105021 18111422 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01029244001 18105021 18111422 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01029244001 18105021 18111422 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029244001 18105021 18111422 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029244001 18105021 18111422 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029244001 18105021 18111422 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029244001 18105021 18111422 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029244001 18105021 18111422 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029244001 18105021 18111422 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029244001 18105021 18111422 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029244001 18105021 18111422 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029244001 18105021 18111422 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029244001 18105021 18111422 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029244001 18105021 18111422 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029244001 18105021 18111422 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01029244001 18105021 18111422 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01029244001 18105021 18111422 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01029244001 18105021 18111422 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01029244001 18105021 18111422 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01029244001 18105021 18111422 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01029244001 18105021 18111422 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01029244001 18105021 18111422 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01029244001 18105021 18111422 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01029244001 18105021 18111422 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01029244001 18105021 18111422 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01029244001 18105021 18111422 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01029244001 18105021 18111422 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01029244001 18105021 18111422 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01029244001 18105021 18111422 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01029244001 18105021 18111422 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01029244001 18105021 18111422 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01029244001 18105021 18111422 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01029244001 18105021 18111422 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01029244001 18105021 18111422 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01029244001 18105021 18111422 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01029244001 18105021 18111422 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01029244001 18105021 18111422 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01029244001 18105021 18111422 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01001411001 18834451 18840157 GSVIVG01009947001 12718755 12724364 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01009947001 12718755 12724364 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01009947001 12718755 12724364 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01009947001 12718755 12724364 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01009947001 12718755 12724364 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01009947001 12718755 12724364 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01009947001 12718755 12724364 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01009947001 12718755 12724364 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01009947001 12718755 12724364 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01009947001 12718755 12724364 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01009947001 12718755 12724364 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01009947001 12718755 12724364 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01009947001 12718755 12724364 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01009947001 12718755 12724364 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01009947001 12718755 12724364 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01009947001 12718755 12724364 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01009947001 12718755 12724364 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01009947001 12718755 12724364 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01009947001 12718755 12724364 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01009947001 12718755 12724364 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01009947001 12718755 12724364 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01009947001 12718755 12724364 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01009947001 12718755 12724364 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01009947001 12718755 12724364 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01009947001 12718755 12724364 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01009947001 12718755 12724364 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01009947001 12718755 12724364 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01009947001 12718755 12724364 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01009947001 12718755 12724364 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01009947001 12718755 12724364 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01009947001 12718755 12724364 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01009947001 12718755 12724364 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01009947001 12718755 12724364 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01009947001 12718755 12724364 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01009947001 12718755 12724364 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01009947001 12718755 12724364 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01009947001 12718755 12724364 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01009947001 12718755 12724364 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01009947001 12718755 12724364 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01009947001 12718755 12724364 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01030950001 19600809 19600919 GSVIVG01026141001 12841595 12849720 GSVIVG01038131001 23707921 23710490 GO:0006614 SRP-dependent cotranslational protein targeting to membrane The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. IEA GO:0005786 signal recognition particle, endoplasmic reticulum targeting A ribonucleoprotein particle of 325 kDa composed of a 7S (300 nucleotide) RNA molecule and a complex of six different polypeptides. This binds both to the N-terminal signal peptide for proteins destined for the endoplasmic reticulum as they emerge from the large ribosomal subunit and also to the ribosome. This binding arrests further translation thereby preventing the proteins from being released into the cytosol. The SRP-ribosome complex then diffuses to the endoplasmic reticulum where it is bound to the signal recognition particle receptor, which allows resumption of protein synthesis and facilitates the passage of the growing polypeptide chain through the translocon. Through a process involving GTP hydrolysis, the SRP-SRP receptor complex dissociates and SRP returns to the cytosol. Of the six polypeptides of SRP the 54 kDa subunit (SRP54) is the central player. It contains an N-terminal GTPase domain and a C-terminal domain that binds directly to the signal peptide and the SRP RNA. Examples of this component are found in Mus musculus, Saccharomyces cerevisiae and Arabidopsis thaliana. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01038131001 23707921 23710490 GO:0006614 SRP-dependent cotranslational protein targeting to membrane The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. IEA GO:0048500 signal recognition particle A complex of protein and RNA which facilitates translocation of proteins across membranes. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01038131001 23707921 23710490 GO:0045900 negative regulation of translational elongation Any process that stops, prevents or reduces the frequency, rate or extent of translational elongation. IEA GO:0005786 signal recognition particle, endoplasmic reticulum targeting A ribonucleoprotein particle of 325 kDa composed of a 7S (300 nucleotide) RNA molecule and a complex of six different polypeptides. This binds both to the N-terminal signal peptide for proteins destined for the endoplasmic reticulum as they emerge from the large ribosomal subunit and also to the ribosome. This binding arrests further translation thereby preventing the proteins from being released into the cytosol. The SRP-ribosome complex then diffuses to the endoplasmic reticulum where it is bound to the signal recognition particle receptor, which allows resumption of protein synthesis and facilitates the passage of the growing polypeptide chain through the translocon. Through a process involving GTP hydrolysis, the SRP-SRP receptor complex dissociates and SRP returns to the cytosol. Of the six polypeptides of SRP the 54 kDa subunit (SRP54) is the central player. It contains an N-terminal GTPase domain and a C-terminal domain that binds directly to the signal peptide and the SRP RNA. Examples of this component are found in Mus musculus, Saccharomyces cerevisiae and Arabidopsis thaliana. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01038131001 23707921 23710490 GO:0045900 negative regulation of translational elongation Any process that stops, prevents or reduces the frequency, rate or extent of translational elongation. IEA GO:0048500 signal recognition particle A complex of protein and RNA which facilitates translocation of proteins across membranes. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01038131001 23707921 23710490 GO:0006614 SRP-dependent cotranslational protein targeting to membrane The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. IEA GO:0005786 signal recognition particle, endoplasmic reticulum targeting A ribonucleoprotein particle of 325 kDa composed of a 7S (300 nucleotide) RNA molecule and a complex of six different polypeptides. This binds both to the N-terminal signal peptide for proteins destined for the endoplasmic reticulum as they emerge from the large ribosomal subunit and also to the ribosome. This binding arrests further translation thereby preventing the proteins from being released into the cytosol. The SRP-ribosome complex then diffuses to the endoplasmic reticulum where it is bound to the signal recognition particle receptor, which allows resumption of protein synthesis and facilitates the passage of the growing polypeptide chain through the translocon. Through a process involving GTP hydrolysis, the SRP-SRP receptor complex dissociates and SRP returns to the cytosol. Of the six polypeptides of SRP the 54 kDa subunit (SRP54) is the central player. It contains an N-terminal GTPase domain and a C-terminal domain that binds directly to the signal peptide and the SRP RNA. Examples of this component are found in Mus musculus, Saccharomyces cerevisiae and Arabidopsis thaliana. IEA Interacting selectively and non-covalently with 7S RNA, the RNA component of the signal recognition particle (SRP). IEA GO:0008312 7S RNA binding GSVIVG01038131001 23707921 23710490 GO:0006614 SRP-dependent cotranslational protein targeting to membrane The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. IEA GO:0048500 signal recognition particle A complex of protein and RNA which facilitates translocation of proteins across membranes. IEA Interacting selectively and non-covalently with 7S RNA, the RNA component of the signal recognition particle (SRP). IEA GO:0008312 7S RNA binding GSVIVG01038131001 23707921 23710490 GO:0045900 negative regulation of translational elongation Any process that stops, prevents or reduces the frequency, rate or extent of translational elongation. IEA GO:0005786 signal recognition particle, endoplasmic reticulum targeting A ribonucleoprotein particle of 325 kDa composed of a 7S (300 nucleotide) RNA molecule and a complex of six different polypeptides. This binds both to the N-terminal signal peptide for proteins destined for the endoplasmic reticulum as they emerge from the large ribosomal subunit and also to the ribosome. This binding arrests further translation thereby preventing the proteins from being released into the cytosol. The SRP-ribosome complex then diffuses to the endoplasmic reticulum where it is bound to the signal recognition particle receptor, which allows resumption of protein synthesis and facilitates the passage of the growing polypeptide chain through the translocon. Through a process involving GTP hydrolysis, the SRP-SRP receptor complex dissociates and SRP returns to the cytosol. Of the six polypeptides of SRP the 54 kDa subunit (SRP54) is the central player. It contains an N-terminal GTPase domain and a C-terminal domain that binds directly to the signal peptide and the SRP RNA. Examples of this component are found in Mus musculus, Saccharomyces cerevisiae and Arabidopsis thaliana. IEA Interacting selectively and non-covalently with 7S RNA, the RNA component of the signal recognition particle (SRP). IEA GO:0008312 7S RNA binding GSVIVG01038131001 23707921 23710490 GO:0045900 negative regulation of translational elongation Any process that stops, prevents or reduces the frequency, rate or extent of translational elongation. IEA GO:0048500 signal recognition particle A complex of protein and RNA which facilitates translocation of proteins across membranes. IEA Interacting selectively and non-covalently with 7S RNA, the RNA component of the signal recognition particle (SRP). IEA GO:0008312 7S RNA binding GSVIVG01038131001 23707921 23710490 GO:0006614 SRP-dependent cotranslational protein targeting to membrane The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. IEA GO:0005786 signal recognition particle, endoplasmic reticulum targeting A ribonucleoprotein particle of 325 kDa composed of a 7S (300 nucleotide) RNA molecule and a complex of six different polypeptides. This binds both to the N-terminal signal peptide for proteins destined for the endoplasmic reticulum as they emerge from the large ribosomal subunit and also to the ribosome. This binding arrests further translation thereby preventing the proteins from being released into the cytosol. The SRP-ribosome complex then diffuses to the endoplasmic reticulum where it is bound to the signal recognition particle receptor, which allows resumption of protein synthesis and facilitates the passage of the growing polypeptide chain through the translocon. Through a process involving GTP hydrolysis, the SRP-SRP receptor complex dissociates and SRP returns to the cytosol. Of the six polypeptides of SRP the 54 kDa subunit (SRP54) is the central player. It contains an N-terminal GTPase domain and a C-terminal domain that binds directly to the signal peptide and the SRP RNA. Examples of this component are found in Mus musculus, Saccharomyces cerevisiae and Arabidopsis thaliana. IEA Interacting selectively and non-covalently with an endoplasmic reticulum signal peptide, a specific peptide sequence that acts as a signal to localize the protein within the endoplasmic reticulum. IEA GO:0030942 endoplasmic reticulum signal peptide binding GSVIVG01038131001 23707921 23710490 GO:0006614 SRP-dependent cotranslational protein targeting to membrane The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. IEA GO:0048500 signal recognition particle A complex of protein and RNA which facilitates translocation of proteins across membranes. IEA Interacting selectively and non-covalently with an endoplasmic reticulum signal peptide, a specific peptide sequence that acts as a signal to localize the protein within the endoplasmic reticulum. IEA GO:0030942 endoplasmic reticulum signal peptide binding GSVIVG01038131001 23707921 23710490 GO:0045900 negative regulation of translational elongation Any process that stops, prevents or reduces the frequency, rate or extent of translational elongation. IEA GO:0005786 signal recognition particle, endoplasmic reticulum targeting A ribonucleoprotein particle of 325 kDa composed of a 7S (300 nucleotide) RNA molecule and a complex of six different polypeptides. This binds both to the N-terminal signal peptide for proteins destined for the endoplasmic reticulum as they emerge from the large ribosomal subunit and also to the ribosome. This binding arrests further translation thereby preventing the proteins from being released into the cytosol. The SRP-ribosome complex then diffuses to the endoplasmic reticulum where it is bound to the signal recognition particle receptor, which allows resumption of protein synthesis and facilitates the passage of the growing polypeptide chain through the translocon. Through a process involving GTP hydrolysis, the SRP-SRP receptor complex dissociates and SRP returns to the cytosol. Of the six polypeptides of SRP the 54 kDa subunit (SRP54) is the central player. It contains an N-terminal GTPase domain and a C-terminal domain that binds directly to the signal peptide and the SRP RNA. Examples of this component are found in Mus musculus, Saccharomyces cerevisiae and Arabidopsis thaliana. IEA Interacting selectively and non-covalently with an endoplasmic reticulum signal peptide, a specific peptide sequence that acts as a signal to localize the protein within the endoplasmic reticulum. IEA GO:0030942 endoplasmic reticulum signal peptide binding GSVIVG01038131001 23707921 23710490 GO:0045900 negative regulation of translational elongation Any process that stops, prevents or reduces the frequency, rate or extent of translational elongation. IEA GO:0048500 signal recognition particle A complex of protein and RNA which facilitates translocation of proteins across membranes. IEA Interacting selectively and non-covalently with an endoplasmic reticulum signal peptide, a specific peptide sequence that acts as a signal to localize the protein within the endoplasmic reticulum. IEA GO:0030942 endoplasmic reticulum signal peptide binding GSVIVG01035060001 1246771 1247714 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GSVIVG01035060001 1246771 1247714 GO:0009607 response to biotic stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism. IEA GSVIVG01031702001 3567877 3569214 GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. IEA GO:0005179 hormone activity GSVIVG01031702001 3567877 3569214 GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012158001 965815 971269 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012158001 965815 971269 Interacting selectively and non-covalently with molybdenum (Mo) ions. IEA GO:0030151 molybdenum ion binding GSVIVG01012158001 965815 971269 Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01010039001 13733152 13734200 GSVIVG01031762001 4176729 4178437 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01030301001 9266409 9270604 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000792001 192829 194730 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01000792001 192829 194730 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01000792001 192829 194730 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01000792001 192829 194730 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01022324001 18504906 18505762 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01022324001 18504906 18505762 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01022324001 18504906 18505762 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01034817001 22019851 22029457 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01034817001 22019851 22029457 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01034817001 22019851 22029457 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01034817001 22019851 22029457 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01034817001 22019851 22029457 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01034817001 22019851 22029457 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01034817001 22019851 22029457 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01034817001 22019851 22029457 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01034817001 22019851 22029457 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01034817001 22019851 22029457 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01034817001 22019851 22029457 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01034817001 22019851 22029457 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01034817001 22019851 22029457 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034817001 22019851 22029457 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034817001 22019851 22029457 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034817001 22019851 22029457 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01034817001 22019851 22029457 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01034817001 22019851 22029457 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01034817001 22019851 22029457 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01034817001 22019851 22029457 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01034817001 22019851 22029457 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01034817001 22019851 22029457 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01034817001 22019851 22029457 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01034817001 22019851 22029457 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01005846001 22218407 22219231 GSVIVG01028426001 7438204 7439069 GSVIVG01028248001 4916274 4917658 GSVIVG01024718001 7476195 7479644 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01024718001 7476195 7479644 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01000823001 639519 706589 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity. IEA GO:0004721 phosphoprotein phosphatase activity GSVIVG01000823001 639519 706589 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity. IEA GO:0004721 phosphoprotein phosphatase activity GSVIVG01000823001 639519 706589 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. IEA GO:0004722 protein serine/threonine phosphatase activity GSVIVG01000823001 639519 706589 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. IEA GO:0004722 protein serine/threonine phosphatase activity GSVIVG01000823001 639519 706589 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01000823001 639519 706589 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01000823001 639519 706589 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01000823001 639519 706589 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01005757001 21868386 21885325 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01005757001 21868386 21885325 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01005757001 21868386 21885325 GO:0015833 peptide transport The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01005757001 21868386 21885325 GO:0015833 peptide transport The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01005757001 21868386 21885325 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01005757001 21868386 21885325 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01005757001 21868386 21885325 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01005757001 21868386 21885325 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01005757001 21868386 21885325 GO:0015833 peptide transport The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01005757001 21868386 21885325 GO:0015833 peptide transport The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01005757001 21868386 21885325 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01005757001 21868386 21885325 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01005757001 21868386 21885325 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of, within or between cells. IEA GO:0015197 peptide transporter activity GSVIVG01005757001 21868386 21885325 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of, within or between cells. IEA GO:0015197 peptide transporter activity GSVIVG01005757001 21868386 21885325 GO:0015833 peptide transport The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of, within or between cells. IEA GO:0015197 peptide transporter activity GSVIVG01005757001 21868386 21885325 GO:0015833 peptide transport The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of, within or between cells. IEA GO:0015197 peptide transporter activity GSVIVG01005757001 21868386 21885325 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of, within or between cells. IEA GO:0015197 peptide transporter activity GSVIVG01005757001 21868386 21885325 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of, within or between cells. IEA GO:0015197 peptide transporter activity GSVIVG01005757001 21868386 21885325 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01005757001 21868386 21885325 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01005757001 21868386 21885325 GO:0015833 peptide transport The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01005757001 21868386 21885325 GO:0015833 peptide transport The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01005757001 21868386 21885325 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01005757001 21868386 21885325 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01005757001 21868386 21885325 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01005757001 21868386 21885325 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01005757001 21868386 21885325 GO:0015833 peptide transport The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01005757001 21868386 21885325 GO:0015833 peptide transport The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01005757001 21868386 21885325 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01005757001 21868386 21885325 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01005757001 21868386 21885325 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01005757001 21868386 21885325 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01005757001 21868386 21885325 GO:0015833 peptide transport The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01005757001 21868386 21885325 GO:0015833 peptide transport The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01005757001 21868386 21885325 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01005757001 21868386 21885325 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01005757001 21868386 21885325 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01005757001 21868386 21885325 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01005757001 21868386 21885325 GO:0015833 peptide transport The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01005757001 21868386 21885325 GO:0015833 peptide transport The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01005757001 21868386 21885325 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01005757001 21868386 21885325 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01011701001 4981757 4983176 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01011701001 4981757 4983176 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01011701001 4981757 4983176 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01011701001 4981757 4983176 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01011701001 4981757 4983176 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01011701001 4981757 4983176 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01037029001 8765039 8765911 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor), with the acyl group being converted into alkyl on transfer. IEA GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer GSVIVG01010814001 22918211 22919944 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010814001 22918211 22919944 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014921001 11929907 11931235 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01014921001 11929907 11931235 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01014921001 11929907 11931235 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01014921001 11929907 11931235 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01035726001 3691354 3695277 GSVIVG01033995001 16030211 16033532 GSVIVG01022260001 17969307 17969582 GSVIVG01023620001 8113205 8117905 GO:0006614 SRP-dependent cotranslational protein targeting to membrane The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023620001 8113205 8117905 GO:0006614 SRP-dependent cotranslational protein targeting to membrane The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023620001 8113205 8117905 GO:0006614 SRP-dependent cotranslational protein targeting to membrane The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01023620001 8113205 8117905 GO:0006614 SRP-dependent cotranslational protein targeting to membrane The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01034179001 14597576 14602158 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01009720001 10763027 10780468 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009720001 10763027 10780468 GO:0006284 base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009720001 10763027 10780468 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01002724001 36143537 36156075 GSVIVG01027743001 7358340 7360713 GSVIVG01015147001 1378700 1380629 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015147001 1378700 1380629 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015147001 1378700 1380629 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01015147001 1378700 1380629 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01021184001 2354075 2364349 Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01021184001 2354075 2364349 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021184001 2354075 2364349 Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. IEA GO:0016831 carboxy-lyase activity GSVIVG01021184001 2354075 2364349 Interacting selectively and non-covalently with thiamin pyrophosphate, the diphosphoric ester of thiamin. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases. IEA GO:0030976 thiamin pyrophosphate binding GSVIVG01006453001 26098083 26102656 GSVIVG01022600001 5773177 5775791 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01022600001 5773177 5775791 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01028872001 17930995 17936399 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other. IEA GO:0005337 nucleoside transmembrane transporter activity GSVIVG01026489001 22776367 22794921 GO:0006075 1,3-beta-glucan biosynthetic process The chemical reactions and pathways resulting in the formation of beta-1,3 glucans, compounds composed of glucose residues linked by 1,3-beta-D-glucosidic bonds. IEA GO:0000148 1,3-beta-glucan synthase complex A protein complex that catalyzes the transfer of a glucose moiety from UDP-glucose to a 1,3-beta-D-glucan chain. IEA Catalysis of the reaction: UDP-glucose + 1,3-beta-D-glucosyl(n) = UDP + 1,3-beta-D-glucosyl(n+1). IEA GO:0003843 1,3-beta-glucan synthase activity GSVIVG01026489001 22776367 22794921 GO:0006075 1,3-beta-glucan biosynthetic process The chemical reactions and pathways resulting in the formation of beta-1,3 glucans, compounds composed of glucose residues linked by 1,3-beta-D-glucosidic bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: UDP-glucose + 1,3-beta-D-glucosyl(n) = UDP + 1,3-beta-D-glucosyl(n+1). IEA GO:0003843 1,3-beta-glucan synthase activity GSVIVG01018958001 18354305 18370077 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025485001 394915 397655 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01011998001 2324672 2327945 GSVIVG01035188001 10121211 10125994 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01035188001 10121211 10125994 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01035188001 10121211 10125994 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01035188001 10121211 10125994 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01035188001 10121211 10125994 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01035188001 10121211 10125994 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01035188001 10121211 10125994 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035188001 10121211 10125994 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035188001 10121211 10125994 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01035188001 10121211 10125994 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01012766001 23608567 23609334 GSVIVG01016682001 343615 354566 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01017186001 5134912 5145693 GSVIVG01028626001 11093802 11097518 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028626001 11093802 11097518 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030112001 9967331 9974498 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030112001 9967331 9974498 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01010054001 13869407 13891756 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01006539001 43044633 43045779 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006539001 43044633 43045779 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006539001 43044633 43045779 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01006539001 43044633 43045779 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01006539001 43044633 43045779 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01006539001 43044633 43045779 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01017883001 4296750 4305393 GSVIVG01024237001 108657 115399 GSVIVG01035003001 817348 826514 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01035003001 817348 826514 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01015754001 16956480 16957997 GSVIVG01029163001 18996245 18997241 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01029163001 18996245 18997241 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01029163001 18996245 18997241 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01029163001 18996245 18997241 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01029163001 18996245 18997241 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01029163001 18996245 18997241 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01029163001 18996245 18997241 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01029163001 18996245 18997241 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01012945001 14120527 14120715 GSVIVG01031491001 17980980 17982892 GSVIVG01032391001 26909269 26912506 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01029241001 18137499 18139990 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01029241001 18137499 18139990 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01029241001 18137499 18139990 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01029241001 18137499 18139990 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01030917001 18963923 18964406 GSVIVG01026065001 25046122 25055377 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01026065001 25046122 25055377 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01026065001 25046122 25055377 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01026065001 25046122 25055377 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01031459001 18312413 18313585 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01013629001 1947032 1947686 GSVIVG01014788001 9748021 9752714 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01014788001 9748021 9752714 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01014788001 9748021 9752714 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01014788001 9748021 9752714 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01030692001 13643020 13657273 GSVIVG01033671001 18784465 18787365 GSVIVG01024996001 5406399 5406925 GO:0016068 type I hypersensitivity An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells or basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines. IEA GSVIVG01005827001 313921 319825 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01005827001 313921 319825 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01005827001 313921 319825 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01005827001 313921 319825 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01005827001 313921 319825 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01005827001 313921 319825 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01005827001 313921 319825 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01005827001 313921 319825 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01034222001 12987493 12988349 GSVIVG01032618001 2169120 2171519 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01000015001 2814374 2816491 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000015001 2814374 2816491 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01006976001 29520053 29541682 GSVIVG01012226001 428381 428865 GSVIVG01013749001 7946357 7960766 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage. IEA GO:0016209 antioxidant activity GSVIVG01013749001 7946357 7960766 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01017353001 7092507 7134534 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000954001 22235756 22240368 GSVIVG01034041001 15636379 15644017 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01037805001 7739421 7741910 GSVIVG01028966001 17021167 17025232 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01008382001 2618187 2673179 Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01008382001 2618187 2673179 Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01006246001 24031775 24036904 GSVIVG01022022001 4185717 4195793 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01022022001 4185717 4195793 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01022022001 4185717 4195793 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01022022001 4185717 4195793 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01022022001 4185717 4195793 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01022022001 4185717 4195793 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01022022001 4185717 4195793 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01022022001 4185717 4195793 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01022022001 4185717 4195793 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01022022001 4185717 4195793 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01022022001 4185717 4195793 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01022022001 4185717 4195793 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01022022001 4185717 4195793 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01022022001 4185717 4195793 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01022022001 4185717 4195793 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01022022001 4185717 4195793 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01022022001 4185717 4195793 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022022001 4185717 4195793 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022022001 4185717 4195793 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022022001 4185717 4195793 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022022001 4185717 4195793 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01022022001 4185717 4195793 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01022022001 4185717 4195793 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01022022001 4185717 4195793 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. IEA GO:0022891 substrate-specific transmembrane transporter activity GSVIVG01022680001 14622645 14635079 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01016670001 261021 268977 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0000502 proteasome complex A large multisubunit complex which catalyzes protein degradation. This complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. IEA GO:0004175 endopeptidase activity GSVIVG01016670001 261021 268977 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005839 proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. IEA GO:0004175 endopeptidase activity GSVIVG01016670001 261021 268977 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0019773 proteasome core complex, alpha-subunit complex The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. IEA GO:0004175 endopeptidase activity GSVIVG01016670001 261021 268977 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0000502 proteasome complex A large multisubunit complex which catalyzes protein degradation. This complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. IEA GO:0004175 endopeptidase activity GSVIVG01016670001 261021 268977 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0005839 proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. IEA GO:0004175 endopeptidase activity GSVIVG01016670001 261021 268977 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0019773 proteasome core complex, alpha-subunit complex The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. IEA GO:0004175 endopeptidase activity GSVIVG01016670001 261021 268977 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0000502 proteasome complex A large multisubunit complex which catalyzes protein degradation. This complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core. IEA Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. IEA GO:0004298 threonine-type endopeptidase activity GSVIVG01016670001 261021 268977 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005839 proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. IEA Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. IEA GO:0004298 threonine-type endopeptidase activity GSVIVG01016670001 261021 268977 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0019773 proteasome core complex, alpha-subunit complex The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. IEA GO:0004298 threonine-type endopeptidase activity GSVIVG01016670001 261021 268977 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0000502 proteasome complex A large multisubunit complex which catalyzes protein degradation. This complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core. IEA Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. IEA GO:0004298 threonine-type endopeptidase activity GSVIVG01016670001 261021 268977 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0005839 proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. IEA Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. IEA GO:0004298 threonine-type endopeptidase activity GSVIVG01016670001 261021 268977 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0019773 proteasome core complex, alpha-subunit complex The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. IEA GO:0004298 threonine-type endopeptidase activity GSVIVG01016670001 261021 268977 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0000502 proteasome complex A large multisubunit complex which catalyzes protein degradation. This complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01016670001 261021 268977 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005839 proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01016670001 261021 268977 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0019773 proteasome core complex, alpha-subunit complex The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01016670001 261021 268977 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0000502 proteasome complex A large multisubunit complex which catalyzes protein degradation. This complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01016670001 261021 268977 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0005839 proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01016670001 261021 268977 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0019773 proteasome core complex, alpha-subunit complex The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01016670001 261021 268977 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0000502 proteasome complex A large multisubunit complex which catalyzes protein degradation. This complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01016670001 261021 268977 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005839 proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01016670001 261021 268977 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0019773 proteasome core complex, alpha-subunit complex The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01016670001 261021 268977 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0000502 proteasome complex A large multisubunit complex which catalyzes protein degradation. This complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01016670001 261021 268977 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0005839 proteasome core complex A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01016670001 261021 268977 GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells. IEA GO:0019773 proteasome core complex, alpha-subunit complex The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01014490001 4401589 4404291 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014490001 4401589 4404291 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014490001 4401589 4404291 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014490001 4401589 4404291 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014490001 4401589 4404291 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01014490001 4401589 4404291 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01022784001 16542491 16552676 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01022784001 16542491 16552676 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01022784001 16542491 16552676 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01011403001 29377150 29379027 GSVIVG01036063001 21209023 21218935 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01036063001 21209023 21218935 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01038734001 93490 101594 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01038734001 93490 101594 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01033452001 20573360 20590789 GSVIVG01037672001 6722282 6722658 GSVIVG01008696001 1270455 1281026 GSVIVG01001667001 14095989 14097108 GSVIVG01027068001 18197371 18200740 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027068001 18197371 18200740 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027068001 18197371 18200740 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027068001 18197371 18200740 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027068001 18197371 18200740 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01027068001 18197371 18200740 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01014542001 4971654 4974022 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01016483001 3480947 3487697 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01016483001 3480947 3487697 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01016483001 3480947 3487697 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016483001 3480947 3487697 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01019097001 16763888 16764199 GSVIVG01032564001 28398976 28402070 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01021611001 8002915 8007078 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01021611001 8002915 8007078 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01021611001 8002915 8007078 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01009968001 12908878 12912473 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01009968001 12908878 12912473 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01009968001 12908878 12912473 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01009968001 12908878 12912473 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01016246001 5944228 5969863 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01016246001 5944228 5969863 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01022405001 19756405 19759709 GSVIVG01035818001 4595144 4612704 GSVIVG01001177001 1053379 1054886 GO:0006869 lipid transport The directed movement of lipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a lipid. IEA GO:0008289 lipid binding GSVIVG01019572001 1682443 1688345 GSVIVG01020328001 21281602 21282410 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01016527001 3104318 3114208 GSVIVG01021253001 3016734 3042360 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01021253001 3016734 3042360 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01021253001 3016734 3042360 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01021253001 3016734 3042360 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01021253001 3016734 3042360 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01021253001 3016734 3042360 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01021253001 3016734 3042360 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01021253001 3016734 3042360 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01021253001 3016734 3042360 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01021253001 3016734 3042360 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01021253001 3016734 3042360 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01021253001 3016734 3042360 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01021253001 3016734 3042360 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01021253001 3016734 3042360 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01021253001 3016734 3042360 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01018346001 10720302 10723948 GSVIVG01000558001 7094755 7100348 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01000558001 7094755 7100348 GO:0016311 dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01000558001 7094755 7100348 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. IEA GO:0004725 protein tyrosine phosphatase activity GSVIVG01000558001 7094755 7100348 GO:0016311 dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. IEA Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. IEA GO:0004725 protein tyrosine phosphatase activity GSVIVG01000558001 7094755 7100348 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA Catalysis of the reaction: protein serine/threonine/tyrosine phosphate + H2O = protein serine/threonine/tyrosine + phosphate. IEA GO:0008138 protein tyrosine/serine/threonine phosphatase activity GSVIVG01000558001 7094755 7100348 GO:0016311 dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. IEA Catalysis of the reaction: protein serine/threonine/tyrosine phosphate + H2O = protein serine/threonine/tyrosine + phosphate. IEA GO:0008138 protein tyrosine/serine/threonine phosphatase activity GSVIVG01000558001 7094755 7100348 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. IEA GO:0016791 phosphatase activity GSVIVG01000558001 7094755 7100348 GO:0016311 dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. IEA Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. IEA GO:0016791 phosphatase activity GSVIVG01035653001 3040227 3044954 GSVIVG01032115001 22540227 22540928 GSVIVG01013571001 21078966 21081956 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033427001 20813483 20817394 GO:0006357 regulation of transcription from RNA polymerase II promoter Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. IEA GO:0016592 mediator complex A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. IEA Functions to mediate the interaction of transcriptional activators with the RNA polymerase II-general RNA polymerase II transcription factor complex. IEA GO:0016455 RNA polymerase II transcription mediator activity GSVIVG01037748001 7471403 7478122 Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01037748001 7471403 7478122 Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01037748001 7471403 7478122 Catalysis of the reaction: a long-chain-alcohol + acyl-CoA = a long-chain ester + CoA. IEA GO:0047196 long-chain-alcohol O-fatty-acyltransferase activity GSVIVG01004011001 1308077 1313790 GSVIVG01020202001 9151013 9165751 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01020202001 9151013 9165751 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020202001 9151013 9165751 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01022203001 17424821 17437319 GSVIVG01022135001 16847942 16851831 GSVIVG01033440001 20674895 20675609 GSVIVG01010786001 22567122 22573980 GSVIVG01014535001 4918317 4925158 GSVIVG01012708001 862734 866097 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01012708001 862734 866097 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01007644001 10881836 10883746 GSVIVG01019909001 4399412 4401227 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01019909001 4399412 4401227 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01019909001 4399412 4401227 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01019909001 4399412 4401227 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01034040001 15658151 15661505 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01034040001 15658151 15661505 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01034040001 15658151 15661505 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01034040001 15658151 15661505 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01034040001 15658151 15661505 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01034040001 15658151 15661505 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024295001 619737 622170 GO:0006559 L-phenylalanine catabolic process The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024295001 619737 622170 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024295001 619737 622170 GO:0006559 L-phenylalanine catabolic process The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of ammonia (NH3) to another substance via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. IEA GO:0016211 ammonia ligase activity GSVIVG01024295001 619737 622170 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of ammonia (NH3) to another substance via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. IEA GO:0016211 ammonia ligase activity GSVIVG01024295001 619737 622170 GO:0006559 L-phenylalanine catabolic process The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate. IEA GO:0016841 ammonia-lyase activity GSVIVG01024295001 619737 622170 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate. IEA GO:0016841 ammonia-lyase activity GSVIVG01028219001 4704733 4729261 GSVIVG01004008001 14274024 14312607 Catalysis of the removal of a phosphate group from phosphorylated myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol. IEA GO:0004437 inositol or phosphatidylinositol phosphatase activity GSVIVG01007758001 9360728 9362879 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01007758001 9360728 9362879 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01036297001 3498970 3499935 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01036297001 3498970 3499935 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01036297001 3498970 3499935 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01036297001 3498970 3499935 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032809001 584275 586196 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01032809001 584275 586196 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01011564001 6436135 6443174 GO:0006536 glutamate metabolic process The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01011564001 6436135 6443174 GO:0019752 carboxylic acid metabolic process The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01011564001 6436135 6443174 GO:0006536 glutamate metabolic process The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid. IEA Catalysis of the reaction: L-glutamate = 4-aminobutanoate + CO2. IEA GO:0004351 glutamate decarboxylase activity GSVIVG01011564001 6436135 6443174 GO:0019752 carboxylic acid metabolic process The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). IEA Catalysis of the reaction: L-glutamate = 4-aminobutanoate + CO2. IEA GO:0004351 glutamate decarboxylase activity GSVIVG01011564001 6436135 6443174 GO:0006536 glutamate metabolic process The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid. IEA Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. IEA GO:0016831 carboxy-lyase activity GSVIVG01011564001 6436135 6443174 GO:0019752 carboxylic acid metabolic process The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). IEA Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. IEA GO:0016831 carboxy-lyase activity GSVIVG01011564001 6436135 6443174 GO:0006536 glutamate metabolic process The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01011564001 6436135 6443174 GO:0019752 carboxylic acid metabolic process The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01016740001 841081 844387 GSVIVG01014666001 8363688 8368560 GO:0006535 cysteine biosynthetic process from serine The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01014666001 8363688 8368560 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01014666001 8363688 8368560 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01014666001 8363688 8368560 GO:0019344 cysteine biosynthetic process The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01014666001 8363688 8368560 GO:0006535 cysteine biosynthetic process from serine The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine. IEA Catalysis of the reaction: O3-acetyl-L-serine + H2S = L-cysteine + acetate. IEA GO:0004124 cysteine synthase activity GSVIVG01014666001 8363688 8368560 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: O3-acetyl-L-serine + H2S = L-cysteine + acetate. IEA GO:0004124 cysteine synthase activity GSVIVG01014666001 8363688 8368560 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the reaction: O3-acetyl-L-serine + H2S = L-cysteine + acetate. IEA GO:0004124 cysteine synthase activity GSVIVG01014666001 8363688 8368560 GO:0019344 cysteine biosynthetic process The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid. IEA Catalysis of the reaction: O3-acetyl-L-serine + H2S = L-cysteine + acetate. IEA GO:0004124 cysteine synthase activity GSVIVG01014666001 8363688 8368560 GO:0006535 cysteine biosynthetic process from serine The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01014666001 8363688 8368560 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01014666001 8363688 8368560 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01014666001 8363688 8368560 GO:0019344 cysteine biosynthetic process The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01014666001 8363688 8368560 GO:0006535 cysteine biosynthetic process from serine The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01014666001 8363688 8368560 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01014666001 8363688 8368560 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01014666001 8363688 8368560 GO:0019344 cysteine biosynthetic process The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01029014001 10733325 10734683 GSVIVG01037291001 16378175 16390969 GSVIVG01032012001 23573517 23577244 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032012001 23573517 23577244 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01032012001 23573517 23577244 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01020535001 4726569 4727572 GSVIVG01034422001 16537374 16539048 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: 3-alpha(S)-strictosidine = tryptamine + secologanin. IEA GO:0016844 strictosidine synthase activity GSVIVG01017506001 9579378 9580502 GSVIVG01002328001 34118274 34119553 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA helix. IEA GO:0003678 DNA helicase activity GSVIVG01002328001 34118274 34119553 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029611001 20786271 20787542 GSVIVG01019458001 809083 813431 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01019458001 809083 813431 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01021912001 5687463 5694159 GSVIVG01008065001 6134096 6136429 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01008065001 6134096 6136429 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01008065001 6134096 6136429 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01008065001 6134096 6136429 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01008065001 6134096 6136429 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01008065001 6134096 6136429 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01008065001 6134096 6136429 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01008065001 6134096 6136429 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01007954001 7227854 7230829 GO:0006452 translational frameshifting A mechanism whereby different proteins may result from a single mRNA molecule, due to a change in the parsing of three nucleotides per codon relative to an initiating AUG codon. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01007954001 7227854 7230829 GO:0008612 peptidyl-lysine modification to hypusine The posttranslational modification of peptidyl-lysine to form hypusine, N6-(4-amino-2-hydroxybutyl)-L-lysine. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01007954001 7227854 7230829 GO:0045901 positive regulation of translational elongation Any process that activates or increases the frequency, rate or extent of translational elongation. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01007954001 7227854 7230829 GO:0045905 positive regulation of translational termination Any process that activates or increases the frequency, rate or extent of translational termination. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01007954001 7227854 7230829 GO:0006452 translational frameshifting A mechanism whereby different proteins may result from a single mRNA molecule, due to a change in the parsing of three nucleotides per codon relative to an initiating AUG codon. IEA Functions in chain elongation during polypeptide synthesis at the ribosome. IEA GO:0003746 translation elongation factor activity GSVIVG01007954001 7227854 7230829 GO:0008612 peptidyl-lysine modification to hypusine The posttranslational modification of peptidyl-lysine to form hypusine, N6-(4-amino-2-hydroxybutyl)-L-lysine. IEA Functions in chain elongation during polypeptide synthesis at the ribosome. IEA GO:0003746 translation elongation factor activity GSVIVG01007954001 7227854 7230829 GO:0045901 positive regulation of translational elongation Any process that activates or increases the frequency, rate or extent of translational elongation. IEA Functions in chain elongation during polypeptide synthesis at the ribosome. IEA GO:0003746 translation elongation factor activity GSVIVG01007954001 7227854 7230829 GO:0045905 positive regulation of translational termination Any process that activates or increases the frequency, rate or extent of translational termination. IEA Functions in chain elongation during polypeptide synthesis at the ribosome. IEA GO:0003746 translation elongation factor activity GSVIVG01007954001 7227854 7230829 GO:0006452 translational frameshifting A mechanism whereby different proteins may result from a single mRNA molecule, due to a change in the parsing of three nucleotides per codon relative to an initiating AUG codon. IEA Interacting selectively and non-covalently with any part of a ribosome. IEA GO:0043022 ribosome binding GSVIVG01007954001 7227854 7230829 GO:0008612 peptidyl-lysine modification to hypusine The posttranslational modification of peptidyl-lysine to form hypusine, N6-(4-amino-2-hydroxybutyl)-L-lysine. IEA Interacting selectively and non-covalently with any part of a ribosome. IEA GO:0043022 ribosome binding GSVIVG01007954001 7227854 7230829 GO:0045901 positive regulation of translational elongation Any process that activates or increases the frequency, rate or extent of translational elongation. IEA Interacting selectively and non-covalently with any part of a ribosome. IEA GO:0043022 ribosome binding GSVIVG01007954001 7227854 7230829 GO:0045905 positive regulation of translational termination Any process that activates or increases the frequency, rate or extent of translational termination. IEA Interacting selectively and non-covalently with any part of a ribosome. IEA GO:0043022 ribosome binding GSVIVG01013975001 8238724 8257811 GSVIVG01016448001 3804813 3808263 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01016448001 3804813 3808263 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01016448001 3804813 3808263 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01016448001 3804813 3808263 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01027391001 15348468 15363814 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GSVIVG01024933001 5930838 5932814 GSVIVG01035741001 3843673 3850303 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01037093001 29203050 29240693 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01037093001 29203050 29240693 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01037093001 29203050 29240693 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01037093001 29203050 29240693 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01037093001 29203050 29240693 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01037093001 29203050 29240693 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01028195001 4536462 4539170 GSVIVG01005294001 20331234 20331800 GSVIVG01004571001 39111575 39113470 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01004571001 39111575 39113470 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). IEA GO:0016769 transferase activity, transferring nitrogenous groups GSVIVG01004571001 39111575 39113470 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + methylthioadenosine. IEA GO:0016847 1-aminocyclopropane-1-carboxylate synthase activity GSVIVG01004571001 39111575 39113470 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01036149001 20053508 20057813 GO:0006471 protein amino acid ADP-ribosylation The transfer, from NAD, of ADP-ribose to protein amino acids. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor. IEA GO:0003950 NAD+ ADP-ribosyltransferase activity GSVIVG01036149001 20053508 20057813 GO:0006471 protein amino acid ADP-ribosylation The transfer, from NAD, of ADP-ribose to protein amino acids. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor. IEA GO:0003950 NAD+ ADP-ribosyltransferase activity GSVIVG01008006001 6742444 6747234 GSVIVG01038352001 13407575 13418368 GSVIVG01012363001 37777 41092 GSVIVG01023221001 20973791 20974667 GSVIVG01028348001 6427600 6429432 GSVIVG01009629001 10039446 10043834 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with a mating-type factor pheromone to initiate a change in cell activity. IEA GO:0004932 mating-type factor pheromone receptor activity GSVIVG01009629001 10039446 10043834 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with a mating-type factor pheromone to initiate a change in cell activity. IEA GO:0004932 mating-type factor pheromone receptor activity GSVIVG01009629001 10039446 10043834 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01009629001 10039446 10043834 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01009629001 10039446 10043834 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01009629001 10039446 10043834 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01014730001 9040136 9050827 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01014730001 9040136 9050827 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Combining with a steroid hormone to initiate a change in cell activity. IEA GO:0003707 steroid hormone receptor activity GSVIVG01014730001 9040136 9050827 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene. IEA GO:0005496 steroid binding GSVIVG01018546001 13549223 13575272 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01018546001 13549223 13575272 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01018546001 13549223 13575272 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01018546001 13549223 13575272 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01032214001 21451060 21451860 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. IEA GO:0008080 N-acetyltransferase activity GSVIVG01024022001 1691668 1692986 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01028935001 17238817 17239970 GSVIVG01011908001 3065975 3080363 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01011908001 3065975 3080363 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01011908001 3065975 3080363 GO:0046836 glycolipid transport The directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01011908001 3065975 3080363 GO:0046836 glycolipid transport The directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01011908001 3065975 3080363 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Enables the directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of, within or between cells. IEA GO:0017089 glycolipid transporter activity GSVIVG01011908001 3065975 3080363 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of, within or between cells. IEA GO:0017089 glycolipid transporter activity GSVIVG01011908001 3065975 3080363 GO:0046836 glycolipid transport The directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Enables the directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of, within or between cells. IEA GO:0017089 glycolipid transporter activity GSVIVG01011908001 3065975 3080363 GO:0046836 glycolipid transport The directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of, within or between cells. IEA GO:0017089 glycolipid transporter activity GSVIVG01011908001 3065975 3080363 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a glycolipid, any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic moiety such as an acylglycerol, a sphingoid, a ceramide (N-acylsphingoid) or a prenyl phosphate. IEA GO:0051861 glycolipid binding GSVIVG01011908001 3065975 3080363 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a glycolipid, any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic moiety such as an acylglycerol, a sphingoid, a ceramide (N-acylsphingoid) or a prenyl phosphate. IEA GO:0051861 glycolipid binding GSVIVG01011908001 3065975 3080363 GO:0046836 glycolipid transport The directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a glycolipid, any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic moiety such as an acylglycerol, a sphingoid, a ceramide (N-acylsphingoid) or a prenyl phosphate. IEA GO:0051861 glycolipid binding GSVIVG01011908001 3065975 3080363 GO:0046836 glycolipid transport The directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a glycolipid, any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic moiety such as an acylglycerol, a sphingoid, a ceramide (N-acylsphingoid) or a prenyl phosphate. IEA GO:0051861 glycolipid binding GSVIVG01031009001 20785446 20791572 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA Catalysis of the reaction: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA. IEA GO:0004045 aminoacyl-tRNA hydrolase activity GSVIVG01019191001 3772508 3772612 GSVIVG01030335001 8700102 8703539 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01008607001 443670 454615 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024784001 6975020 6977493 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029482001 22366563 22368806 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029482001 22366563 22368806 Catalysis of the transfer of a functional group from one position to another within a single molecule. IEA GO:0016866 intramolecular transferase activity GSVIVG01034334001 17912499 17919694 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01034334001 17912499 17919694 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01034334001 17912499 17919694 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01034334001 17912499 17919694 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01034334001 17912499 17919694 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01034334001 17912499 17919694 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01031658001 19716799 19720405 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01031658001 19716799 19720405 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01031658001 19716799 19720405 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01031658001 19716799 19720405 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031658001 19716799 19720405 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027581001 15352692 15353151 GSVIVG01034759001 9138247 9142644 GSVIVG01017799001 3561840 3569669 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01017799001 3561840 3569669 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with double-stranded RNA. IEA GO:0003725 double-stranded RNA binding GSVIVG01011363001 28957049 28982200 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GSVIVG01001501001 5174724 5174901 GSVIVG01037634001 6413980 6416816 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01037634001 6413980 6416816 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01007865001 8195928 8201207 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01007865001 8195928 8201207 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01007865001 8195928 8201207 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01013625001 1842078 1866688 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01013625001 1842078 1866688 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013625001 1842078 1866688 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01017570001 10741910 10742260 GSVIVG01019820001 3615152 3630010 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01034446001 16111583 16112311 GSVIVG01024088001 1231025 1235642 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012084001 1569135 1570145 GSVIVG01030540001 6588642 6597129 GSVIVG01010653001 15611865 15613023 GSVIVG01011327001 8536191 8539219 GSVIVG01002953001 37338196 37340019 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01001418001 18915284 18918742 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001418001 18915284 18918742 Catalysis of the elimination of H2S or substituted H2S. IEA GO:0016846 carbon-sulfur lyase activity GSVIVG01001418001 18915284 18918742 Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01025631001 13467681 13470511 GSVIVG01020388001 20230675 20232220 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025926001 27159397 27180532 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025926001 27159397 27180532 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0010181 FMN binding GSVIVG01025926001 27159397 27180532 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01028020001 3232525 3239673 GSVIVG01035903001 5599592 5606765 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01035903001 5599592 5606765 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01035903001 5599592 5606765 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01035903001 5599592 5606765 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035903001 5599592 5606765 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035903001 5599592 5606765 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01028400001 7145246 7164031 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01028400001 7145246 7164031 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01028400001 7145246 7164031 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01028400001 7145246 7164031 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01028400001 7145246 7164031 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027008001 18604356 18607525 GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA GSVIVG01012968001 11576142 11579157 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01012968001 11576142 11579157 Catalysis of the reaction: ATP + shikimate = ADP + shikimate 3-phosphate. IEA GO:0004765 shikimate kinase activity GSVIVG01012968001 11576142 11579157 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012968001 11576142 11579157 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01016817001 1642184 1646517 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01016817001 1642184 1646517 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01030708001 14227565 14229608 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01009357001 7711468 7715556 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01018035001 5713010 5714251 GSVIVG01012836001 5946783 5950016 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin. IEA GO:0004221 ubiquitin thiolesterase activity GSVIVG01012836001 5946783 5950016 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01012022001 2131271 2131795 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012022001 2131271 2131795 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01016696001 430173 440183 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01027726001 7189687 7189941 GSVIVG01000807001 344282 344656 GSVIVG01023304001 19889093 19890495 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036360001 4207769 4210077 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01036360001 4207769 4210077 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01021857001 6441932 6442911 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01030314001 9059607 9067736 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01034187001 14570244 14573991 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01034187001 14570244 14573991 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01003320001 9008338 9008885 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01003320001 9008338 9008885 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01003320001 9008338 9008885 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Stops, prevents or reduces the activity of a cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004869 cysteine-type endopeptidase inhibitor activity GSVIVG01003320001 9008338 9008885 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Stops, prevents or reduces the activity of a cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004869 cysteine-type endopeptidase inhibitor activity GSVIVG01003320001 9008338 9008885 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds. IEA GO:0030414 peptidase inhibitor activity GSVIVG01003320001 9008338 9008885 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds. IEA GO:0030414 peptidase inhibitor activity GSVIVG01031230001 1022491 1028180 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: diphosphate + H2O = 2 phosphate. IEA GO:0004427 inorganic diphosphatase activity GSVIVG01031230001 1022491 1028180 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of pyrophosphate, which generates a proton motive force. IEA GO:0009678 hydrogen-translocating pyrophosphatase activity GSVIVG01031230001 1022491 1028180 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01021085001 1317168 1319658 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01021085001 1317168 1319658 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01029605001 20833126 20833523 GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01005840001 22181351 22185228 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01005840001 22181351 22185228 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01006254001 24106839 24107574 GSVIVG01004890001 16454061 16457844 GSVIVG01016590001 2570307 2579787 GSVIVG01018939001 18526671 18529110 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01018939001 18526671 18529110 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01018939001 18526671 18529110 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01018939001 18526671 18529110 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01018939001 18526671 18529110 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01018939001 18526671 18529110 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01038137001 23764864 23781962 GO:0016458 gene silencing Any transcriptional or post-transcriptional process carried out at the cellular level that results in long-term gene inactivation. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01027681001 14359079 14385440 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + Na+(out) = amino acid(in) + Na+(in). IEA GO:0005283 sodium:amino acid symporter activity GSVIVG01027681001 14359079 14385440 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01027767001 7508084 7513654 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01006301001 24742949 24746975 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01006301001 24742949 24746975 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01006301001 24742949 24746975 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01006301001 24742949 24746975 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036883001 18286859 18288238 GSVIVG01009961001 12853194 12856039 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01014380001 3253145 3253999 GSVIVG01028851001 18083405 18086266 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01011593001 6138234 6155954 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01011593001 6138234 6155954 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01007811001 8786988 8791406 GSVIVG01005052001 17724412 17730172 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01005052001 17724412 17730172 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003222001 14162394 14167671 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01017722001 2906780 2913701 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01006274001 24409833 24415551 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01032207001 21548091 21549162 GSVIVG01032047001 23204922 23205531 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01009025001 4373836 4375011 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035251001 11381698 11383195 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035251001 11381698 11383195 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01023570001 9464096 9470147 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023570001 9464096 9470147 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01023570001 9464096 9470147 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023570001 9464096 9470147 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023570001 9464096 9470147 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01023570001 9464096 9470147 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01035231001 10884890 10889188 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01020828001 1467463 1470527 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01014351001 2944712 2949299 GO:0009103 lipopolysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate. IEA GO:0008690 3-deoxy-manno-octulosonate cytidylyltransferase activity GSVIVG01037056001 8281115 8302826 GO:0006364 rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01034718001 8338356 8338673 GSVIVG01013368001 922458 926763 GSVIVG01003182001 7640047 7653796 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01014598001 5459288 5477423 GSVIVG01010994001 2361493 2364820 GSVIVG01037703001 7105463 7108433 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030586001 6919936 6921951 GSVIVG01020500001 18355036 18355749 GSVIVG01034405001 16794586 16806059 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01009416001 8174092 8185174 Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01038152001 23911538 23913016 GO:0006631 fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01038152001 23911538 23913016 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01038152001 23911538 23913016 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01038152001 23911538 23913016 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01038152001 23911538 23913016 GO:0006631 fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of the reaction: stearoyl-[acyl-carrier protein] + reduced acceptor + O2 = oleoyl-[acyl-carrier protein] + acceptor + H2O. The enzyme requires ferredoxin. IEA GO:0045300 acyl-[acyl-carrier-protein] desaturase activity GSVIVG01038152001 23911538 23913016 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of the reaction: stearoyl-[acyl-carrier protein] + reduced acceptor + O2 = oleoyl-[acyl-carrier protein] + acceptor + H2O. The enzyme requires ferredoxin. IEA GO:0045300 acyl-[acyl-carrier-protein] desaturase activity GSVIVG01038152001 23911538 23913016 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of the reaction: stearoyl-[acyl-carrier protein] + reduced acceptor + O2 = oleoyl-[acyl-carrier protein] + acceptor + H2O. The enzyme requires ferredoxin. IEA GO:0045300 acyl-[acyl-carrier-protein] desaturase activity GSVIVG01038152001 23911538 23913016 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Catalysis of the reaction: stearoyl-[acyl-carrier protein] + reduced acceptor + O2 = oleoyl-[acyl-carrier protein] + acceptor + H2O. The enzyme requires ferredoxin. IEA GO:0045300 acyl-[acyl-carrier-protein] desaturase activity GSVIVG01038152001 23911538 23913016 GO:0006631 fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01038152001 23911538 23913016 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01038152001 23911538 23913016 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01038152001 23911538 23913016 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01012450001 1003837 1005566 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GSVIVG01012450001 1003837 1005566 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GSVIVG01004954001 17002614 17010022 GSVIVG01020136001 9947452 9962409 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01013098001 8319467 8330139 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01013098001 8319467 8330139 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01013098001 8319467 8330139 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01017212001 5495170 5499348 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain A protein complex that forms part of a proton-transporting two-sector ATPase complex and carries out proton transport across a membrane. The proton-transporting domain (F0, V0, or A0) includes integral and peripheral membrane proteins. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01017212001 5495170 5499348 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0033179 proton-transporting V-type ATPase, V0 domain A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01017229001 5693712 5697598 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01017229001 5693712 5697598 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01017229001 5693712 5697598 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017229001 5693712 5697598 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017229001 5693712 5697598 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01017229001 5693712 5697598 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01005933001 22834307 22834396 GSVIVG01031452001 18344970 18357515 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031452001 18344970 18357515 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01006732001 27827233 27829859 GSVIVG01019600001 1850587 1857501 GSVIVG01025709001 12787402 12789802 GSVIVG01001724001 518224 522280 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030268001 9660691 9664196 GSVIVG01021323001 4024027 4029294 GO:0006413 translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01021323001 4024027 4029294 GO:0006413 translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. IEA GO:0003743 translation initiation factor activity GSVIVG01032977001 24755457 24769714 GSVIVG01019593001 1817153 1820380 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01019593001 1817153 1820380 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with ribosomal RNA. IEA GO:0019843 rRNA binding GSVIVG01014123001 572713 579099 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01028528001 9266634 9267422 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01028528001 9266634 9267422 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01028528001 9266634 9267422 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01028528001 9266634 9267422 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01010055001 13901947 13917102 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01009998001 13303082 13304738 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01009998001 13303082 13304738 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01009998001 13303082 13304738 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01009998001 13303082 13304738 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01019430001 634437 638469 GSVIVG01033573001 19649698 19650549 GSVIVG01019135001 16332209 16334957 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01019135001 16332209 16334957 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01034193001 14521629 14524967 GSVIVG01025212001 3267313 3275141 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01025212001 3267313 3275141 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01025212001 3267313 3275141 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01025212001 3267313 3275141 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033151001 8484123 8513037 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033151001 8484123 8513037 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01033151001 8484123 8513037 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033151001 8484123 8513037 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033151001 8484123 8513037 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01033151001 8484123 8513037 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01008650001 102558 106388 GSVIVG01008563001 847010 847712 GSVIVG01032656001 1777201 1784213 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01032656001 1777201 1784213 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027846001 8586198 8587539 GSVIVG01026472001 23005418 23029795 GSVIVG01009955001 12783608 12784590 GSVIVG01022129001 16806821 16808445 GSVIVG01019817001 3569892 3585997 GO:0006506 GPI anchor biosynthetic process The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol moiety is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate moiety, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage. IEA GO:0005789 endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum. IEA GSVIVG01019817001 3569892 3585997 GO:0006506 GPI anchor biosynthetic process The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol moiety is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate moiety, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01031383001 19317055 19318953 GSVIVG01030001001 8844772 8846699 GSVIVG01001776001 3016806 3018204 GSVIVG01025619001 13541021 13545614 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01025619001 13541021 13545614 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01025619001 13541021 13545614 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01025619001 13541021 13545614 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01025619001 13541021 13545614 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01025619001 13541021 13545614 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025619001 13541021 13545614 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025619001 13541021 13545614 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025619001 13541021 13545614 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025619001 13541021 13545614 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025619001 13541021 13545614 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01025619001 13541021 13545614 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01025619001 13541021 13545614 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01025619001 13541021 13545614 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01025619001 13541021 13545614 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01025100001 4494225 4498626 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025100001 4494225 4498626 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01035469001 1514831 1524551 GSVIVG01013556001 20808222 20809533 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA Catalysis of the reaction: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA. IEA GO:0004045 aminoacyl-tRNA hydrolase activity GSVIVG01012851001 6132631 6135949 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01009165001 5663288 5667315 GO:0015976 carbon utilization A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbon sources and then activates genes to scavenge the last traces of the primary carbon source and to transport and metabolize alternative carbon sources such as carbon dioxide or carbonic acid. The utilization process begins when the cell or organism detects carbon levels, includes the activation of genes whose products detect, transport or metabolize carbon-containing substances, and ends when carbon is incorporated into the cell or organism's metabolism. IEA Catalysis of the reaction: H2CO3 = CO2 + H2O. IEA GO:0004089 carbonate dehydratase activity GSVIVG01009165001 5663288 5667315 GO:0015976 carbon utilization A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbon sources and then activates genes to scavenge the last traces of the primary carbon source and to transport and metabolize alternative carbon sources such as carbon dioxide or carbonic acid. The utilization process begins when the cell or organism detects carbon levels, includes the activation of genes whose products detect, transport or metabolize carbon-containing substances, and ends when carbon is incorporated into the cell or organism's metabolism. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008916001 3369964 3370941 GO:0016068 type I hypersensitivity An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells or basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines. IEA GSVIVG01037879001 6811803 6813183 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01037879001 6811803 6813183 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028957001 17084120 17084161 GSVIVG01029169001 18962055 18972989 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029169001 18962055 18972989 GO:0009228 thiamin biosynthetic process The chemical reactions and pathways resulting in the formation of thiamin (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029169001 18962055 18972989 GO:0016114 terpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029169001 18962055 18972989 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. IEA GO:0008661 1-deoxy-D-xylulose-5-phosphate synthase activity GSVIVG01029169001 18962055 18972989 GO:0009228 thiamin biosynthetic process The chemical reactions and pathways resulting in the formation of thiamin (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver. IEA Catalysis of the reaction: pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. IEA GO:0008661 1-deoxy-D-xylulose-5-phosphate synthase activity GSVIVG01029169001 18962055 18972989 GO:0016114 terpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure. IEA Catalysis of the reaction: pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. IEA GO:0008661 1-deoxy-D-xylulose-5-phosphate synthase activity GSVIVG01029169001 18962055 18972989 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide. IEA GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor GSVIVG01029169001 18962055 18972989 GO:0009228 thiamin biosynthetic process The chemical reactions and pathways resulting in the formation of thiamin (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver. IEA Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide. IEA GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor GSVIVG01029169001 18962055 18972989 GO:0016114 terpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure. IEA Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide. IEA GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor GSVIVG01015052001 721735 734938 GSVIVG01021553001 6957710 6965185 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01021553001 6957710 6965185 GO:0009725 response to hormone stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01021553001 6957710 6965185 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01032415001 27152774 27157752 GSVIVG01016872001 2149307 2153081 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016872001 2149307 2153081 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01016872001 2149307 2153081 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01009854001 11794593 11803508 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01009854001 11794593 11803508 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01009854001 11794593 11803508 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01009854001 11794593 11803508 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01009854001 11794593 11803508 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01009854001 11794593 11803508 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01010414001 20344365 20348920 GSVIVG01015254001 2138263 2142340 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01015254001 2138263 2142340 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01015254001 2138263 2142340 GO:0006421 asparaginyl-tRNA aminoacylation The process of coupling asparagine to asparaginyl-tRNA, catalyzed by asparaginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01015254001 2138263 2142340 GO:0006422 aspartyl-tRNA aminoacylation The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01015254001 2138263 2142340 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01015254001 2138263 2142340 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01015254001 2138263 2142340 GO:0006421 asparaginyl-tRNA aminoacylation The process of coupling asparagine to asparaginyl-tRNA, catalyzed by asparaginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01015254001 2138263 2142340 GO:0006422 aspartyl-tRNA aminoacylation The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01015254001 2138263 2142340 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01015254001 2138263 2142340 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01015254001 2138263 2142340 GO:0006421 asparaginyl-tRNA aminoacylation The process of coupling asparagine to asparaginyl-tRNA, catalyzed by asparaginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01015254001 2138263 2142340 GO:0006422 aspartyl-tRNA aminoacylation The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01015254001 2138263 2142340 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp). IEA GO:0004815 aspartate-tRNA ligase activity GSVIVG01015254001 2138263 2142340 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp). IEA GO:0004815 aspartate-tRNA ligase activity GSVIVG01015254001 2138263 2142340 GO:0006421 asparaginyl-tRNA aminoacylation The process of coupling asparagine to asparaginyl-tRNA, catalyzed by asparaginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp). IEA GO:0004815 aspartate-tRNA ligase activity GSVIVG01015254001 2138263 2142340 GO:0006422 aspartyl-tRNA aminoacylation The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp). IEA GO:0004815 aspartate-tRNA ligase activity GSVIVG01015254001 2138263 2142340 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn). IEA GO:0004816 asparagine-tRNA ligase activity GSVIVG01015254001 2138263 2142340 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn). IEA GO:0004816 asparagine-tRNA ligase activity GSVIVG01015254001 2138263 2142340 GO:0006421 asparaginyl-tRNA aminoacylation The process of coupling asparagine to asparaginyl-tRNA, catalyzed by asparaginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn). IEA GO:0004816 asparagine-tRNA ligase activity GSVIVG01015254001 2138263 2142340 GO:0006422 aspartyl-tRNA aminoacylation The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn). IEA GO:0004816 asparagine-tRNA ligase activity GSVIVG01015254001 2138263 2142340 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015254001 2138263 2142340 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015254001 2138263 2142340 GO:0006421 asparaginyl-tRNA aminoacylation The process of coupling asparagine to asparaginyl-tRNA, catalyzed by asparaginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015254001 2138263 2142340 GO:0006422 aspartyl-tRNA aminoacylation The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01004976001 17199145 17199756 GO:0042773 ATP synthesis coupled electron transport The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP. IEA Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. IEA GO:0008137 NADH dehydrogenase (ubiquinone) activity GSVIVG01004976001 17199145 17199756 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. IEA GO:0008137 NADH dehydrogenase (ubiquinone) activity GSVIVG01007436001 31871273 31874229 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01034377001 17164912 17165339 GSVIVG01022490001 3779955 3782699 GSVIVG01036460001 22317395 22324014 GSVIVG01022783001 16537604 16542457 GSVIVG01008603001 484106 501880 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006225001 23757982 23759376 GSVIVG01027335001 16363325 16368453 GSVIVG01008306001 3419333 3425533 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01018751001 20212286 20219286 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018751001 20212286 20219286 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01009639001 10118698 10119983 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01034882001 15868705 15869062 GSVIVG01024021001 1707520 1708550 GSVIVG01008127001 5559256 5576076 GSVIVG01009565001 9460577 9471201 GSVIVG01038429001 12107372 12108867 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01032645001 1843217 1852800 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032645001 1843217 1852800 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a phosphate group (acceptor). IEA GO:0016776 phosphotransferase activity, phosphate group as acceptor GSVIVG01032645001 1843217 1852800 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Catalysis of the reaction: ATP + nucleoside monophosphate = ADP + nucleoside diphosphate. IEA GO:0019201 nucleotide kinase activity GSVIVG01032645001 1843217 1852800 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate. IEA GO:0019205 nucleobase, nucleoside, nucleotide kinase activity GSVIVG01000143001 15614445 15616183 GSVIVG01022992001 17214039 17216090 GSVIVG01035295001 162911 165161 The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01026080001 24839031 24849802 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01026080001 24839031 24849802 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01026080001 24839031 24849802 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01026080001 24839031 24849802 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01026080001 24839031 24849802 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01026080001 24839031 24849802 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01026080001 24839031 24849802 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01026080001 24839031 24849802 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01026080001 24839031 24849802 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01026080001 24839031 24849802 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Stops, prevents or reduces the activity of a cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004869 cysteine-type endopeptidase inhibitor activity GSVIVG01026080001 24839031 24849802 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Stops, prevents or reduces the activity of a cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004869 cysteine-type endopeptidase inhibitor activity GSVIVG01026080001 24839031 24849802 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Stops, prevents or reduces the activity of a cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004869 cysteine-type endopeptidase inhibitor activity GSVIVG01026080001 24839031 24849802 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Stops, prevents or reduces the activity of a cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004869 cysteine-type endopeptidase inhibitor activity GSVIVG01026080001 24839031 24849802 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Stops, prevents or reduces the activity of a cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004869 cysteine-type endopeptidase inhibitor activity GSVIVG01026080001 24839031 24849802 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Stops, prevents or reduces the activity of a cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004869 cysteine-type endopeptidase inhibitor activity GSVIVG01026080001 24839031 24849802 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Stops, prevents or reduces the activity of a cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004869 cysteine-type endopeptidase inhibitor activity GSVIVG01026080001 24839031 24849802 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Stops, prevents or reduces the activity of a cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004869 cysteine-type endopeptidase inhibitor activity GSVIVG01026080001 24839031 24849802 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Stops, prevents or reduces the activity of a cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004869 cysteine-type endopeptidase inhibitor activity GSVIVG01026080001 24839031 24849802 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01026080001 24839031 24849802 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01026080001 24839031 24849802 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01026080001 24839031 24849802 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01026080001 24839031 24849802 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01026080001 24839031 24849802 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01026080001 24839031 24849802 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01026080001 24839031 24849802 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01026080001 24839031 24849802 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01014079001 201970 211104 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin. IEA GO:0004221 ubiquitin thiolesterase activity GSVIVG01019319001 1169411 1187657 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01019319001 1169411 1187657 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01019319001 1169411 1187657 GO:0006422 aspartyl-tRNA aminoacylation The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01019319001 1169411 1187657 GO:0006430 lysyl-tRNA aminoacylation The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01019319001 1169411 1187657 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01019319001 1169411 1187657 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01019319001 1169411 1187657 GO:0006422 aspartyl-tRNA aminoacylation The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01019319001 1169411 1187657 GO:0006430 lysyl-tRNA aminoacylation The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01019319001 1169411 1187657 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01019319001 1169411 1187657 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01019319001 1169411 1187657 GO:0006422 aspartyl-tRNA aminoacylation The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01019319001 1169411 1187657 GO:0006430 lysyl-tRNA aminoacylation The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01019319001 1169411 1187657 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp). IEA GO:0004815 aspartate-tRNA ligase activity GSVIVG01019319001 1169411 1187657 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp). IEA GO:0004815 aspartate-tRNA ligase activity GSVIVG01019319001 1169411 1187657 GO:0006422 aspartyl-tRNA aminoacylation The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp). IEA GO:0004815 aspartate-tRNA ligase activity GSVIVG01019319001 1169411 1187657 GO:0006430 lysyl-tRNA aminoacylation The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp). IEA GO:0004815 aspartate-tRNA ligase activity GSVIVG01019319001 1169411 1187657 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys). IEA GO:0004824 lysine-tRNA ligase activity GSVIVG01019319001 1169411 1187657 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys). IEA GO:0004824 lysine-tRNA ligase activity GSVIVG01019319001 1169411 1187657 GO:0006422 aspartyl-tRNA aminoacylation The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys). IEA GO:0004824 lysine-tRNA ligase activity GSVIVG01019319001 1169411 1187657 GO:0006430 lysyl-tRNA aminoacylation The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys). IEA GO:0004824 lysine-tRNA ligase activity GSVIVG01019319001 1169411 1187657 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019319001 1169411 1187657 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019319001 1169411 1187657 GO:0006422 aspartyl-tRNA aminoacylation The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019319001 1169411 1187657 GO:0006430 lysyl-tRNA aminoacylation The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036059001 21269900 21279608 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005667 transcription factor complex A protein complex, distinct from RNA polymerase, that associates with DNA at promoters or at cis-acting regulatory sequences, by direct binding or by interaction with other DNA-binding polypeptides or complexes, and regulates transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01031640001 19440333 19441268 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01011702001 4966029 4973928 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01011702001 4966029 4973928 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01011702001 4966029 4973928 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01011702001 4966029 4973928 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023821001 3201265 3203036 GSVIVG01015183001 1617849 1624642 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01015183001 1617849 1624642 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01015183001 1617849 1624642 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01005600001 40830695 40831762 GO:0006278 RNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01005600001 40830695 40831762 GO:0006278 RNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. IEA Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time. IEA GO:0003964 RNA-directed DNA polymerase activity GSVIVG01036867001 18476519 18476964 GSVIVG01001802001 25898569 25932462 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01038710001 20727488 20735214 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01038710001 20727488 20735214 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01038710001 20727488 20735214 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029383001 15920269 15928175 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01009081001 4788238 4789038 GSVIVG01014503001 4582370 4583095 GSVIVG01020918001 17239625 17245674 GSVIVG01032503001 27951972 27957751 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of potassium ions (K+) from one side of a membrane to the other. IEA GO:0015079 potassium ion transmembrane transporter activity GSVIVG01008709001 1365467 1370757 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0005835 fatty acid synthase complex A multienzyme complex that catalyses the synthesis of fatty acids from acetyl CoA. IEA Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+. IEA GO:0004312 fatty acid synthase activity GSVIVG01008709001 1365467 1370757 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005835 fatty acid synthase complex A multienzyme complex that catalyses the synthesis of fatty acids from acetyl CoA. IEA Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+. IEA GO:0004312 fatty acid synthase activity GSVIVG01008709001 1365467 1370757 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005835 fatty acid synthase complex A multienzyme complex that catalyses the synthesis of fatty acids from acetyl CoA. IEA Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+. IEA GO:0004312 fatty acid synthase activity GSVIVG01008709001 1365467 1370757 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0005835 fatty acid synthase complex A multienzyme complex that catalyses the synthesis of fatty acids from acetyl CoA. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008709001 1365467 1370757 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005835 fatty acid synthase complex A multienzyme complex that catalyses the synthesis of fatty acids from acetyl CoA. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008709001 1365467 1370757 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005835 fatty acid synthase complex A multienzyme complex that catalyses the synthesis of fatty acids from acetyl CoA. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01007715001 9989635 10000315 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01007715001 9989635 10000315 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01007715001 9989635 10000315 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01007715001 9989635 10000315 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01007715001 9989635 10000315 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01007715001 9989635 10000315 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01007715001 9989635 10000315 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01007715001 9989635 10000315 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01007240001 31037102 31038623 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01007240001 31037102 31038623 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033539001 19874869 19876226 GSVIVG01016467001 3607022 3625231 GO:0006561 proline biosynthetic process The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016467001 3607022 3625231 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016467001 3607022 3625231 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016467001 3607022 3625231 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016467001 3607022 3625231 GO:0006561 proline biosynthetic process The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-glutamate = ADP + L-glutamate 5-phosphate. IEA GO:0004349 glutamate 5-kinase activity GSVIVG01016467001 3607022 3625231 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-glutamate = ADP + L-glutamate 5-phosphate. IEA GO:0004349 glutamate 5-kinase activity GSVIVG01016467001 3607022 3625231 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-glutamate = ADP + L-glutamate 5-phosphate. IEA GO:0004349 glutamate 5-kinase activity GSVIVG01016467001 3607022 3625231 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-glutamate = ADP + L-glutamate 5-phosphate. IEA GO:0004349 glutamate 5-kinase activity GSVIVG01016467001 3607022 3625231 GO:0006561 proline biosynthetic process The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: L-glutamate 5-semialdehyde + phosphate + NADP+ = L-gamma-glutamyl 5-phosphate + NADPH + H+. IEA GO:0004350 glutamate-5-semialdehyde dehydrogenase activity GSVIVG01016467001 3607022 3625231 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: L-glutamate 5-semialdehyde + phosphate + NADP+ = L-gamma-glutamyl 5-phosphate + NADPH + H+. IEA GO:0004350 glutamate-5-semialdehyde dehydrogenase activity GSVIVG01016467001 3607022 3625231 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: L-glutamate 5-semialdehyde + phosphate + NADP+ = L-gamma-glutamyl 5-phosphate + NADPH + H+. IEA GO:0004350 glutamate-5-semialdehyde dehydrogenase activity GSVIVG01016467001 3607022 3625231 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: L-glutamate 5-semialdehyde + phosphate + NADP+ = L-gamma-glutamyl 5-phosphate + NADPH + H+. IEA GO:0004350 glutamate-5-semialdehyde dehydrogenase activity GSVIVG01016467001 3607022 3625231 GO:0006561 proline biosynthetic process The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016467001 3607022 3625231 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016467001 3607022 3625231 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016467001 3607022 3625231 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016467001 3607022 3625231 GO:0006561 proline biosynthetic process The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01016467001 3607022 3625231 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01016467001 3607022 3625231 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01016467001 3607022 3625231 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01008027001 6515381 6546950 GSVIVG01011819001 3858749 3861883 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01011819001 3858749 3861883 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01016261001 5813987 5818974 GO:0009416 response to light stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01016261001 5813987 5818974 GO:0009416 response to light stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01011349001 28871527 28879083 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019947001 12600856 12602313 GSVIVG01032869001 106656 108168 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. IEA GO:0005179 hormone activity GSVIVG01032869001 106656 108168 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. IEA GO:0005179 hormone activity GSVIVG01010275001 18751026 18752609 GSVIVG01025339001 1875239 1882842 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01025339001 1875239 1882842 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01025339001 1875239 1882842 GO:0031408 oxylipin biosynthetic process The chemical reactions and pathways resulting in the formation of any oxylipin, any of a group of biologically active compounds formed by oxidative metabolism of polyunsaturated fatty acids. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01025339001 1875239 1882842 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01025339001 1875239 1882842 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Catalysis of the reaction: linoleate + O2 = (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate. IEA GO:0016165 lipoxygenase activity GSVIVG01025339001 1875239 1882842 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the reaction: linoleate + O2 = (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate. IEA GO:0016165 lipoxygenase activity GSVIVG01025339001 1875239 1882842 GO:0031408 oxylipin biosynthetic process The chemical reactions and pathways resulting in the formation of any oxylipin, any of a group of biologically active compounds formed by oxidative metabolism of polyunsaturated fatty acids. IEA Catalysis of the reaction: linoleate + O2 = (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate. IEA GO:0016165 lipoxygenase activity GSVIVG01025339001 1875239 1882842 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: linoleate + O2 = (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate. IEA GO:0016165 lipoxygenase activity GSVIVG01025339001 1875239 1882842 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025339001 1875239 1882842 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025339001 1875239 1882842 GO:0031408 oxylipin biosynthetic process The chemical reactions and pathways resulting in the formation of any oxylipin, any of a group of biologically active compounds formed by oxidative metabolism of polyunsaturated fatty acids. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025339001 1875239 1882842 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025339001 1875239 1882842 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor. IEA GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen GSVIVG01025339001 1875239 1882842 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor. IEA GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen GSVIVG01025339001 1875239 1882842 GO:0031408 oxylipin biosynthetic process The chemical reactions and pathways resulting in the formation of any oxylipin, any of a group of biologically active compounds formed by oxidative metabolism of polyunsaturated fatty acids. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor. IEA GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen GSVIVG01025339001 1875239 1882842 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor. IEA GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen GSVIVG01025339001 1875239 1882842 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01025339001 1875239 1882842 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01025339001 1875239 1882842 GO:0031408 oxylipin biosynthetic process The chemical reactions and pathways resulting in the formation of any oxylipin, any of a group of biologically active compounds formed by oxidative metabolism of polyunsaturated fatty acids. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01025339001 1875239 1882842 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01038402001 11807140 11809362 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01038402001 11807140 11809362 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01038402001 11807140 11809362 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01038402001 11807140 11809362 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01038402001 11807140 11809362 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038402001 11807140 11809362 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038402001 11807140 11809362 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01038402001 11807140 11809362 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01035125001 1650303 1654995 GO:0007017 microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. IEA GO:0005875 microtubule associated complex Any multimeric complex connected to a microtubule. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01009268001 6831204 6834669 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01005163001 18869481 18876420 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01005163001 18869481 18876420 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01005163001 18869481 18876420 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01005163001 18869481 18876420 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020715001 2805370 2810033 GSVIVG01008950001 3748756 3757534 GO:0009725 response to hormone stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01008950001 3748756 3757534 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01028477001 8138317 8140330 GSVIVG01019449001 765535 773252 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01024655001 7986332 7988366 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01031675001 19988255 20024363 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01031675001 19988255 20024363 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031675001 19988255 20024363 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. IEA GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GSVIVG01031675001 19988255 20024363 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species. IEA GO:0031418 L-ascorbic acid binding GSVIVG01025125001 4209736 4216927 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025125001 4209736 4216927 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025125001 4209736 4216927 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA Catalysis of a reaction that results in the formation of carbamoyl phosphate. IEA GO:0004086 carbamoyl-phosphate synthase activity GSVIVG01025125001 4209736 4216927 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a reaction that results in the formation of carbamoyl phosphate. IEA GO:0004086 carbamoyl-phosphate synthase activity GSVIVG01025125001 4209736 4216927 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025125001 4209736 4216927 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024599001 8545320 8546675 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01024599001 8545320 8546675 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01024599001 8545320 8546675 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01024599001 8545320 8546675 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01024599001 8545320 8546675 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024599001 8545320 8546675 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024599001 8545320 8546675 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01024599001 8545320 8546675 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01024599001 8545320 8546675 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01024599001 8545320 8546675 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01026370001 15167439 15175571 GSVIVG01011408001 29409938 29423532 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01011408001 29409938 29423532 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0045095 keratin filament A filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells. The keratins are the most diverse classes of IF proteins, with a large number of keratin isoforms being expressed. Each type of epithelium always expresses a characteristic combination of type I and type II keratins. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01011408001 29409938 29423532 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01011408001 29409938 29423532 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0045095 keratin filament A filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells. The keratins are the most diverse classes of IF proteins, with a large number of keratin isoforms being expressed. Each type of epithelium always expresses a characteristic combination of type I and type II keratins. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01011408001 29409938 29423532 GO:0051276 chromosome organization A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01011408001 29409938 29423532 GO:0051276 chromosome organization A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. IEA GO:0045095 keratin filament A filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells. The keratins are the most diverse classes of IF proteins, with a large number of keratin isoforms being expressed. Each type of epithelium always expresses a characteristic combination of type I and type II keratins. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01011408001 29409938 29423532 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01011408001 29409938 29423532 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0045095 keratin filament A filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells. The keratins are the most diverse classes of IF proteins, with a large number of keratin isoforms being expressed. Each type of epithelium always expresses a characteristic combination of type I and type II keratins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01011408001 29409938 29423532 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01011408001 29409938 29423532 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0045095 keratin filament A filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells. The keratins are the most diverse classes of IF proteins, with a large number of keratin isoforms being expressed. Each type of epithelium always expresses a characteristic combination of type I and type II keratins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01011408001 29409938 29423532 GO:0051276 chromosome organization A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01011408001 29409938 29423532 GO:0051276 chromosome organization A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. IEA GO:0045095 keratin filament A filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells. The keratins are the most diverse classes of IF proteins, with a large number of keratin isoforms being expressed. Each type of epithelium always expresses a characteristic combination of type I and type II keratins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01011408001 29409938 29423532 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01011408001 29409938 29423532 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0045095 keratin filament A filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells. The keratins are the most diverse classes of IF proteins, with a large number of keratin isoforms being expressed. Each type of epithelium always expresses a characteristic combination of type I and type II keratins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01011408001 29409938 29423532 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01011408001 29409938 29423532 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0045095 keratin filament A filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells. The keratins are the most diverse classes of IF proteins, with a large number of keratin isoforms being expressed. Each type of epithelium always expresses a characteristic combination of type I and type II keratins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01011408001 29409938 29423532 GO:0051276 chromosome organization A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01011408001 29409938 29423532 GO:0051276 chromosome organization A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. IEA GO:0045095 keratin filament A filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells. The keratins are the most diverse classes of IF proteins, with a large number of keratin isoforms being expressed. Each type of epithelium always expresses a characteristic combination of type I and type II keratins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01011408001 29409938 29423532 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011408001 29409938 29423532 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0045095 keratin filament A filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells. The keratins are the most diverse classes of IF proteins, with a large number of keratin isoforms being expressed. Each type of epithelium always expresses a characteristic combination of type I and type II keratins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011408001 29409938 29423532 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011408001 29409938 29423532 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0045095 keratin filament A filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells. The keratins are the most diverse classes of IF proteins, with a large number of keratin isoforms being expressed. Each type of epithelium always expresses a characteristic combination of type I and type II keratins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011408001 29409938 29423532 GO:0051276 chromosome organization A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011408001 29409938 29423532 GO:0051276 chromosome organization A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. IEA GO:0045095 keratin filament A filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells. The keratins are the most diverse classes of IF proteins, with a large number of keratin isoforms being expressed. Each type of epithelium always expresses a characteristic combination of type I and type II keratins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011541001 12710240 12715877 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01020380001 20325372 20326176 GSVIVG01026494001 22723683 22725448 GSVIVG01033438001 20684163 20686138 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin. IEA GO:0004221 ubiquitin thiolesterase activity GSVIVG01015274001 2322073 2327635 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025686001 12956263 12956451 GSVIVG01001001001 11280784 11288203 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA Catalysis of the reaction: protein serine/threonine/tyrosine phosphate + H2O = protein serine/threonine/tyrosine + phosphate. IEA GO:0008138 protein tyrosine/serine/threonine phosphatase activity GSVIVG01001001001 11280784 11288203 GO:0016311 dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. IEA Catalysis of the reaction: protein serine/threonine/tyrosine phosphate + H2O = protein serine/threonine/tyrosine + phosphate. IEA GO:0008138 protein tyrosine/serine/threonine phosphatase activity GSVIVG01001001001 11280784 11288203 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. IEA GO:0016791 phosphatase activity GSVIVG01001001001 11280784 11288203 GO:0016311 dephosphorylation The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. IEA Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. IEA GO:0016791 phosphatase activity GSVIVG01000083001 3311501 3315829 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01000083001 3311501 3315829 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: linoleate + O2 = (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate. IEA GO:0016165 lipoxygenase activity GSVIVG01000083001 3311501 3315829 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor. IEA GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen GSVIVG01000083001 3311501 3315829 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01017946001 4948289 4950406 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01017946001 4948289 4950406 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01024780001 7007487 7012438 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GSVIVG01016111001 19147986 19148888 GSVIVG01014075001 153174 156479 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin and L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. IEA GO:0008113 peptide-methionine-(S)-S-oxide reductase activity GSVIVG01033246001 22222013 22228833 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. IEA GO:0003743 translation initiation factor activity GSVIVG01033246001 22222013 22228833 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. IEA GO:0003743 translation initiation factor activity GSVIVG01033246001 22222013 22228833 GO:0006413 translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. IEA Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. IEA GO:0003743 translation initiation factor activity GSVIVG01033246001 22222013 22228833 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. IEA GO:0003743 translation initiation factor activity GSVIVG01033246001 22222013 22228833 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033246001 22222013 22228833 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033246001 22222013 22228833 GO:0006413 translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033246001 22222013 22228833 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033246001 22222013 22228833 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01033246001 22222013 22228833 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01033246001 22222013 22228833 GO:0006413 translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01033246001 22222013 22228833 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01033246001 22222013 22228833 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01033246001 22222013 22228833 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01033246001 22222013 22228833 GO:0006413 translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01033246001 22222013 22228833 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01021945001 5292623 5293377 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01003434001 14985641 15015710 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01003434001 14985641 15015710 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01003434001 14985641 15015710 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01003434001 14985641 15015710 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003434001 14985641 15015710 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01003434001 14985641 15015710 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01020207001 9035171 9039037 GSVIVG01037163001 28419313 28427465 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01037163001 28419313 28427465 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01030819001 16642691 16645352 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01002019001 32324549 32326480 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01016993001 3246544 3252734 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016993001 3246544 3252734 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016993001 3246544 3252734 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01016993001 3246544 3252734 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01003168001 6030245 6032840 GSVIVG01035575001 2408000 2428839 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01035575001 2408000 2428839 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01024087001 1235713 1237448 GSVIVG01037380001 14713803 14738733 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01033145001 8446667 8446942 Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01002201001 33300292 33302522 GSVIVG01029436001 22906692 22911440 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01001231001 1661882 1663484 GSVIVG01032459001 27639106 27640916 GSVIVG01030620001 7214592 7215394 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01033532001 19956664 19960330 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01033532001 19956664 19960330 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01033532001 19956664 19960330 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01026987001 18779360 18786610 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01036449001 22124290 22125983 GSVIVG01033915001 16772904 16774068 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033915001 16772904 16774068 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033915001 16772904 16774068 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033915001 16772904 16774068 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01033915001 16772904 16774068 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01033915001 16772904 16774068 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01033915001 16772904 16774068 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033915001 16772904 16774068 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033915001 16772904 16774068 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033915001 16772904 16774068 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01033915001 16772904 16774068 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01033915001 16772904 16774068 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01033915001 16772904 16774068 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033915001 16772904 16774068 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033915001 16772904 16774068 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01027519001 16011941 16015492 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01011359001 28935655 28941655 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01011359001 28935655 28941655 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01009192001 5939861 5949524 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01009192001 5939861 5949524 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01009192001 5939861 5949524 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01009192001 5939861 5949524 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01009192001 5939861 5949524 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01009192001 5939861 5949524 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032892001 23848298 23848892 GSVIVG01032954001 24574272 24590308 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012571001 3761507 3762502 GSVIVG01010269001 18638901 18641794 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01010269001 18638901 18641794 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01010269001 18638901 18641794 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01010269001 18638901 18641794 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01010269001 18638901 18641794 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01010269001 18638901 18641794 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01010269001 18638901 18641794 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01010269001 18638901 18641794 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01010269001 18638901 18641794 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01010269001 18638901 18641794 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01033656001 18900812 18903815 GSVIVG01026478001 22946145 22947428 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009522 photosystem I A photosystem that contains an iron-sulfur reaction center associated with accessory pigments and electron carriers. In cyanobacteria and chloroplasts, photosystem I functions as a light-dependent plastocyanin-ferredoxin oxidoreductase, transferring electrons from plastocyanin to ferredoxin; in photosynthetic bacteria that have only a single type I photosystem, such as the green sulfur bacteria, electrons can go either to ferredoxin (Fd) -> NAD+ or to menaquinone (MK) -> Cytb/FeS -> Cytc555 -> photosystem I (cyclic photophosphorylation). IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01026478001 22946145 22947428 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0042651 thylakoid membrane The pigmented membrane of any thylakoid. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017245001 5869125 5869506 GSVIVG01010878001 16502598 16510211 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar. IEA GO:0008375 acetylglucosaminyltransferase activity GSVIVG01034346001 17718839 17723402 GO:0045941 positive regulation of transcription Any cellular process that activates or increases the frequency, rate or extent of transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any activity that increases the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule following transcription initiation. IEA GO:0008159 positive transcription elongation factor activity GSVIVG01034346001 17718839 17723402 GO:0045941 positive regulation of transcription Any cellular process that activates or increases the frequency, rate or extent of transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01000527001 13705261 13706774 GSVIVG01032611001 28813586 28826094 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01032611001 28813586 28826094 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01032611001 28813586 28826094 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01032611001 28813586 28826094 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032611001 28813586 28826094 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001994001 6133007 6134820 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01001994001 6133007 6134820 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01001994001 6133007 6134820 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01001994001 6133007 6134820 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01032509001 27990561 27993818 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01002251001 33692054 33695580 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01002251001 33692054 33695580 GO:0009081 branched chain family amino acid metabolic process The chemical reactions and pathways involving amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01002251001 33692054 33695580 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: a branched-chain amino acid + 2-oxoglutarate = L-glutamate + a 2-oxocarboxylate derived from the branched-chain amino acid. Includes catalysis of the reaction: L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate and anaologous reactions involving L-isoleucine and L-valine. IEA GO:0004084 branched-chain-amino-acid transaminase activity GSVIVG01002251001 33692054 33695580 GO:0009081 branched chain family amino acid metabolic process The chemical reactions and pathways involving amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. IEA Catalysis of the reaction: a branched-chain amino acid + 2-oxoglutarate = L-glutamate + a 2-oxocarboxylate derived from the branched-chain amino acid. Includes catalysis of the reaction: L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate and anaologous reactions involving L-isoleucine and L-valine. IEA GO:0004084 branched-chain-amino-acid transaminase activity GSVIVG01011213001 9543734 9547523 GSVIVG01015242001 2064163 2071154 GSVIVG01012939001 13895318 13953615 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA GSVIVG01033237001 22309657 22314735 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01033237001 22309657 22314735 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01015528001 4508248 4590694 GSVIVG01033230001 22373986 22380033 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01022303001 18359009 18365971 GSVIVG01030840001 17377401 17380965 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01030840001 17377401 17380965 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01030840001 17377401 17380965 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01030840001 17377401 17380965 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016512001 3250536 3259029 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01016512001 3250536 3259029 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01016512001 3250536 3259029 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01016512001 3250536 3259029 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01016512001 3250536 3259029 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016512001 3250536 3259029 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021522001 6564396 6572444 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021522001 6564396 6572444 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01038136001 23741225 23764340 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01038136001 23741225 23764340 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01038136001 23741225 23764340 Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 5' end. IEA GO:0008409 5'-3' exonuclease activity GSVIVG01012314001 13514842 13518100 GSVIVG01030742001 14921652 14926665 GSVIVG01014552001 5064341 5067797 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01014552001 5064341 5067797 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01030537001 6564061 6572507 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030537001 6564061 6572507 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030537001 6564061 6572507 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030537001 6564061 6572507 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01030537001 6564061 6572507 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01030537001 6564061 6572507 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01035757001 4031894 4032929 GSVIVG01011325001 8526558 8528876 GSVIVG01021838001 6654650 6665572 GSVIVG01022285001 18214794 18222114 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01022285001 18214794 18222114 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01022285001 18214794 18222114 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01022285001 18214794 18222114 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01022285001 18214794 18222114 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01022285001 18214794 18222114 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01022285001 18214794 18222114 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01022285001 18214794 18222114 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01011154001 7395665 7402805 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01011154001 7395665 7402805 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01016398001 4227263 4228380 GSVIVG01033283001 21880824 21902318 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033283001 21880824 21902318 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01033283001 21880824 21902318 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01033283001 21880824 21902318 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01018838001 19406007 19413705 GSVIVG01030577001 6859365 6862754 GSVIVG01019754001 2989814 2995888 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01019754001 2989814 2995888 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01019754001 2989814 2995888 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01019754001 2989814 2995888 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01019754001 2989814 2995888 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01019754001 2989814 2995888 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01019754001 2989814 2995888 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01019754001 2989814 2995888 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01019754001 2989814 2995888 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01019754001 2989814 2995888 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019754001 2989814 2995888 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019754001 2989814 2995888 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019754001 2989814 2995888 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019754001 2989814 2995888 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019754001 2989814 2995888 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019754001 2989814 2995888 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019754001 2989814 2995888 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019754001 2989814 2995888 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032202001 21581191 21590513 GSVIVG01012566001 3713211 3715651 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01005154001 18748877 18750328 GSVIVG01028973001 16983231 16985468 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01028973001 16983231 16985468 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the transfer of mercury (Hg) ions from one side of a membrane to the other. IEA GO:0015097 mercury ion transmembrane transporter activity GSVIVG01028973001 16983231 16985468 GO:0015694 mercury ion transport The directed movement of mercury (Hg) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01028973001 16983231 16985468 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01027771001 7549865 7550286 GSVIVG01009107001 5102794 5106770 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01009107001 5102794 5106770 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01009107001 5102794 5106770 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01009107001 5102794 5106770 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01018144001 7020779 7024063 GSVIVG01032236001 13546524 13554835 GSVIVG01038564001 21814436 21817575 GSVIVG01024912001 6090804 6092180 GSVIVG01025210001 3278556 3279106 GSVIVG01009606001 9819460 9824402 GSVIVG01029149001 19125141 19145002 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01029149001 19125141 19145002 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01029149001 19125141 19145002 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01029149001 19125141 19145002 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029149001 19125141 19145002 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029708001 13486775 13488712 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01029708001 13486775 13488712 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01029708001 13486775 13488712 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01029708001 13486775 13488712 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01029708001 13486775 13488712 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026933001 19288677 19305960 GO:0006357 regulation of transcription from RNA polymerase II promoter Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter. IEA GO:0016592 mediator complex A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. IEA Functions to mediate the interaction of transcriptional activators with the RNA polymerase II-general RNA polymerase II transcription factor complex. IEA GO:0016455 RNA polymerase II transcription mediator activity GSVIVG01020763001 2279215 2280538 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020763001 2279215 2280538 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01025867001 11018072 11024231 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01015335001 2775101 2777915 GSVIVG01014573001 5318042 5326891 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01014573001 5318042 5326891 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01014573001 5318042 5326891 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01014573001 5318042 5326891 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01014573001 5318042 5326891 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01014573001 5318042 5326891 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01014767001 9421066 9425262 GO:0009086 methionine biosynthetic process The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. IEA Catalysis of the reaction: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine. IEA GO:0003871 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity GSVIVG01022063001 16300878 16303036 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004197 cysteine-type endopeptidase activity GSVIVG01022063001 16300878 16303036 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01030026001 8990937 8998173 GSVIVG01016136001 19568956 19579116 GSVIVG01017669001 2495248 2508560 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01017669001 2495248 2508560 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01017669001 2495248 2508560 GO:0035023 regulation of Rho protein signal transduction Any process that modulates the frequency, rate or extent of Rho protein signal transduction. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01017669001 2495248 2508560 GO:0035023 regulation of Rho protein signal transduction Any process that modulates the frequency, rate or extent of Rho protein signal transduction. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01017669001 2495248 2508560 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate. IEA GO:0003774 motor activity GSVIVG01017669001 2495248 2508560 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate. IEA GO:0003774 motor activity GSVIVG01017669001 2495248 2508560 GO:0035023 regulation of Rho protein signal transduction Any process that modulates the frequency, rate or extent of Rho protein signal transduction. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate. IEA GO:0003774 motor activity GSVIVG01017669001 2495248 2508560 GO:0035023 regulation of Rho protein signal transduction Any process that modulates the frequency, rate or extent of Rho protein signal transduction. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate. IEA GO:0003774 motor activity GSVIVG01017669001 2495248 2508560 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01017669001 2495248 2508560 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01017669001 2495248 2508560 GO:0035023 regulation of Rho protein signal transduction Any process that modulates the frequency, rate or extent of Rho protein signal transduction. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01017669001 2495248 2508560 GO:0035023 regulation of Rho protein signal transduction Any process that modulates the frequency, rate or extent of Rho protein signal transduction. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01017669001 2495248 2508560 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. IEA GO:0005089 Rho guanyl-nucleotide exchange factor activity GSVIVG01017669001 2495248 2508560 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. IEA GO:0005089 Rho guanyl-nucleotide exchange factor activity GSVIVG01017669001 2495248 2508560 GO:0035023 regulation of Rho protein signal transduction Any process that modulates the frequency, rate or extent of Rho protein signal transduction. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. IEA GO:0005089 Rho guanyl-nucleotide exchange factor activity GSVIVG01017669001 2495248 2508560 GO:0035023 regulation of Rho protein signal transduction Any process that modulates the frequency, rate or extent of Rho protein signal transduction. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. IEA GO:0005089 Rho guanyl-nucleotide exchange factor activity GSVIVG01017669001 2495248 2508560 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017669001 2495248 2508560 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017669001 2495248 2508560 GO:0035023 regulation of Rho protein signal transduction Any process that modulates the frequency, rate or extent of Rho protein signal transduction. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017669001 2495248 2508560 GO:0035023 regulation of Rho protein signal transduction Any process that modulates the frequency, rate or extent of Rho protein signal transduction. IEA GO:0005874 microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027175001 17246601 17249921 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008316001 3334900 3336318 GSVIVG01027795001 7815974 7816568 GSVIVG01000796001 209993 212682 GSVIVG01023863001 2911377 2912923 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004197 cysteine-type endopeptidase activity GSVIVG01023863001 2911377 2912923 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01019515001 1248273 1250051 GSVIVG01028072001 3599085 3601359 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01020614001 3752361 3753043 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01020614001 3752361 3753043 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds. IEA GO:0015035 protein disulfide oxidoreductase activity GSVIVG01021430001 5267923 5271409 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01021430001 5267923 5271409 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01017110001 4242148 4248889 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022659001 14239708 14240814 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01001063001 7207530 7207877 GSVIVG01031005001 20728874 20731048 GSVIVG01013929001 6903437 6904334 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01013929001 6903437 6904334 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01013929001 6903437 6904334 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01013929001 6903437 6904334 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01013929001 6903437 6904334 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01013929001 6903437 6904334 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01003172001 5995078 6001048 GSVIVG01034052001 15530516 15560064 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025084001 4643864 4645690 GSVIVG01023409001 12419490 12420870 GSVIVG01016969001 3049294 3057629 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01016969001 3049294 3057629 GO:0031123 RNA 3'-end processing Any process involved in forming the mature 3' end of an RNA molecule. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01016969001 3049294 3057629 GO:0043631 RNA polyadenylation The enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01016969001 3049294 3057629 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the template-independent extension of the 3'- end of an RNA or DNA strand by addition of one adenosine molecule at a time. Cannot initiate a chain 'de novo'. The primer, depending on the source of the enzyme, may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group. IEA GO:0004652 polynucleotide adenylyltransferase activity GSVIVG01016969001 3049294 3057629 GO:0031123 RNA 3'-end processing Any process involved in forming the mature 3' end of an RNA molecule. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the template-independent extension of the 3'- end of an RNA or DNA strand by addition of one adenosine molecule at a time. Cannot initiate a chain 'de novo'. The primer, depending on the source of the enzyme, may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group. IEA GO:0004652 polynucleotide adenylyltransferase activity GSVIVG01016969001 3049294 3057629 GO:0043631 RNA polyadenylation The enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the template-independent extension of the 3'- end of an RNA or DNA strand by addition of one adenosine molecule at a time. Cannot initiate a chain 'de novo'. The primer, depending on the source of the enzyme, may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group. IEA GO:0004652 polynucleotide adenylyltransferase activity GSVIVG01016969001 3049294 3057629 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the transfer of a nucleotidyl group to a reactant. IEA GO:0016779 nucleotidyltransferase activity GSVIVG01016969001 3049294 3057629 GO:0031123 RNA 3'-end processing Any process involved in forming the mature 3' end of an RNA molecule. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the transfer of a nucleotidyl group to a reactant. IEA GO:0016779 nucleotidyltransferase activity GSVIVG01016969001 3049294 3057629 GO:0043631 RNA polyadenylation The enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the transfer of a nucleotidyl group to a reactant. IEA GO:0016779 nucleotidyltransferase activity GSVIVG01035552001 2241932 2243881 GO:0006400 tRNA modification The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically. IEA Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N7-methylguanine. IEA GO:0008176 tRNA (guanine-N7-)-methyltransferase activity GSVIVG01003796001 183527 185569 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01024422001 2379164 2406701 GO:0015969 guanosine tetraphosphate metabolic process The chemical reactions and pathways involving guanine tetraphosphate (5'-ppGpp-3'), a derivative of guanine riboside with four phosphates. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009802001 11348600 11354491 Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum. IEA GO:0003993 acid phosphatase activity GSVIVG01009802001 11348600 11354491 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01009802001 11348600 11354491 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01026934001 19274886 19280565 GSVIVG01028820001 18389482 18392891 GO:0022904 respiratory electron transport chain A process whereby a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016651 oxidoreductase activity, acting on NADH or NADPH GSVIVG01027490001 16293891 16325012 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001043001 6787163 6911536 GSVIVG01013865001 5567308 5665234 GO:0051276 chromosome organization A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01013865001 5567308 5665234 GO:0051276 chromosome organization A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01013865001 5567308 5665234 GO:0051276 chromosome organization A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013865001 5567308 5665234 GO:0051276 chromosome organization A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013865001 5567308 5665234 GO:0051276 chromosome organization A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013865001 5567308 5665234 GO:0051276 chromosome organization A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025322001 2032567 2038906 GSVIVG01011241001 9992012 9993493 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01030177001 10818655 10825442 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01035457001 1403978 1408138 GSVIVG01027687001 14296130 14296961 GSVIVG01036621001 19305952 19306606 GSVIVG01032601001 28760651 28762112 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01011136001 7106210 7106651 GSVIVG01015065001 803065 803805 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of copper (Cu) ions from one side of a membrane to the other. IEA GO:0005375 copper ion transmembrane transporter activity GSVIVG01021947001 5288775 5289939 GSVIVG01024747001 7241761 7244593 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01024747001 7241761 7244593 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01024747001 7241761 7244593 Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor). IEA GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups GSVIVG01024747001 7241761 7244593 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01035850001 4847963 4851533 GSVIVG01003574001 10812434 10813366 GSVIVG01009152001 5605382 5606712 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01009152001 5605382 5606712 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01009152001 5605382 5606712 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01009152001 5605382 5606712 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01009152001 5605382 5606712 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01009152001 5605382 5606712 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01009152001 5605382 5606712 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01009152001 5605382 5606712 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01005634001 20756569 20762764 GSVIVG01001363001 24007478 24009035 GSVIVG01007784001 9063732 9068490 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01007784001 9063732 9068490 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008673001 1101732 1110711 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008673001 1101732 1110711 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01008673001 1101732 1110711 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01006023001 23208221 23212432 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01013486001 1553086 1560733 GSVIVG01005317001 20686001 20687284 GSVIVG01003564001 14683069 14696239 GSVIVG01020503001 18293840 18303006 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01020503001 18293840 18303006 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012882001 6499733 6502531 GSVIVG01027587001 15273728 15289657 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027587001 15273728 15289657 GO:0046470 phosphatidylcholine metabolic process The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027587001 15273728 15289657 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate. IEA GO:0004630 phospholipase D activity GSVIVG01027587001 15273728 15289657 GO:0046470 phosphatidylcholine metabolic process The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate. IEA GO:0004630 phospholipase D activity GSVIVG01027587001 15273728 15289657 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01027587001 15273728 15289657 GO:0046470 phosphatidylcholine metabolic process The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01004069001 739115 739914 GSVIVG01034728001 8529789 8532025 GSVIVG01013548001 20536235 20592925 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion. IEA GO:0004806 triglyceride lipase activity GSVIVG01011473001 29927006 29930415 GO:0032955 regulation of barrier septum formation Any process that modulates the frequency, rate or extent of barrier septum formation. Barrier septum formation is the assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. IEA GSVIVG01011473001 29927006 29930415 GO:0051301 cell division The process resulting in the physical partitioning and separation of a cell into daughter cells. IEA GSVIVG01015894001 19009143 19010994 GSVIVG01020538001 4688607 4688864 GSVIVG01028458001 7898438 7912112 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028458001 7898438 7912112 Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01003156001 6146663 6148747 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01001170001 1087563 1089570 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01021136001 1747000 1752281 GSVIVG01034556001 19508351 19517807 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01015576001 5122943 5128748 GO:0032313 regulation of Rab GTPase activity Any process that modulates the activity of a GTPase of the Rab family. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Increases the rate of GTP hydrolysis by a GTPase of the Rab family. IEA GO:0005097 Rab GTPase activator activity GSVIVG01007187001 30745853 30746212 GSVIVG01011635001 5701247 5706199 GSVIVG01008028001 6500054 6505038 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01008028001 6500054 6505038 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015935 small ribosomal subunit The smaller of the two subunits of a ribosome. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01008028001 6500054 6505038 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01008028001 6500054 6505038 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015935 small ribosomal subunit The smaller of the two subunits of a ribosome. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01008028001 6500054 6505038 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ribosomal RNA. IEA GO:0019843 rRNA binding GSVIVG01008028001 6500054 6505038 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015935 small ribosomal subunit The smaller of the two subunits of a ribosome. IEA Interacting selectively and non-covalently with ribosomal RNA. IEA GO:0019843 rRNA binding GSVIVG01028695001 19743261 19744148 GSVIVG01009734001 10849334 10854811 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01014035001 9532118 9532444 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01005666001 21016591 21022961 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin and L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. IEA GO:0008113 peptide-methionine-(S)-S-oxide reductase activity GSVIVG01022294001 18295651 18296919 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01018177001 13600998 13603801 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01018177001 13600998 13603801 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01035030001 1020755 1038389 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035030001 1020755 1038389 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035030001 1020755 1038389 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035030001 1020755 1038389 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01035030001 1020755 1038389 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01035030001 1020755 1038389 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01035030001 1020755 1038389 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01035030001 1020755 1038389 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01035030001 1020755 1038389 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of the reaction: ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. IEA GO:0004618 phosphoglycerate kinase activity GSVIVG01035030001 1020755 1038389 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the reaction: ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. IEA GO:0004618 phosphoglycerate kinase activity GSVIVG01035030001 1020755 1038389 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. IEA GO:0004618 phosphoglycerate kinase activity GSVIVG01035030001 1020755 1038389 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Catalysis of the reaction: ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. IEA GO:0004618 phosphoglycerate kinase activity GSVIVG01025491001 364396 365387 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01025491001 364396 365387 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01024560001 8845624 8848695 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01024560001 8845624 8848695 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01028720001 19456031 19462846 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1). IEA GO:0004326 tetrahydrofolylpolyglutamate synthase activity GSVIVG01028720001 19456031 19462846 GO:0009396 folic acid and derivative biosynthetic process The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. IEA Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1). IEA GO:0004326 tetrahydrofolylpolyglutamate synthase activity GSVIVG01028720001 19456031 19462846 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028720001 19456031 19462846 GO:0009396 folic acid and derivative biosynthetic process The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028720001 19456031 19462846 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01028720001 19456031 19462846 GO:0009396 folic acid and derivative biosynthetic process The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01017284001 6355929 6357166 GSVIVG01009345001 7580653 7584189 GO:0009767 photosynthetic electron transport chain A process, occurring as part of photosynthesis, whereby light provides the energy for a series of electron carriers to operate together to transfer electrons and generate a transmembrane electrochemical gradient. IEA GO:0009521 photosystem A complex located in a photosynthetic membrane that consists of a photoreaction center associated with accessory pigments and electron carriers. Examples of this component are found in Arabidopsis thaliana and in photosynthetic bacterial and archaeal species. IEA Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. IEA GO:0016168 chlorophyll binding GSVIVG01009345001 7580653 7584189 GO:0009767 photosynthetic electron transport chain A process, occurring as part of photosynthesis, whereby light provides the energy for a series of electron carriers to operate together to transfer electrons and generate a transmembrane electrochemical gradient. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. IEA GO:0016168 chlorophyll binding GSVIVG01009345001 7580653 7584189 GO:0019684 photosynthesis, light reaction The light reactions of photosynthesis, which take place in photosystems II and I. Light energy is harvested and used to power the transfer of electrons among a series of electron donors and acceptors. The final electron acceptor is NADP+, which is reduced to NADPH. NADPH generated from light reactions is used in sugar synthesis in dark reactions. Light reactions also generate a proton motive force across the thylakoid membrane, and the proton gradient is used to synthesize ATP. There are two chemical reactions involved in the light reactions: water oxidation in photosystem II, and NADP reduction in photosystem I. IEA GO:0009521 photosystem A complex located in a photosynthetic membrane that consists of a photoreaction center associated with accessory pigments and electron carriers. Examples of this component are found in Arabidopsis thaliana and in photosynthetic bacterial and archaeal species. IEA Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. IEA GO:0016168 chlorophyll binding GSVIVG01009345001 7580653 7584189 GO:0019684 photosynthesis, light reaction The light reactions of photosynthesis, which take place in photosystems II and I. Light energy is harvested and used to power the transfer of electrons among a series of electron donors and acceptors. The final electron acceptor is NADP+, which is reduced to NADPH. NADPH generated from light reactions is used in sugar synthesis in dark reactions. Light reactions also generate a proton motive force across the thylakoid membrane, and the proton gradient is used to synthesize ATP. There are two chemical reactions involved in the light reactions: water oxidation in photosystem II, and NADP reduction in photosystem I. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment. IEA GO:0016168 chlorophyll binding GSVIVG01004411001 38456599 38458366 Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01004411001 38456599 38458366 Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01004005001 14260736 14264382 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01004005001 14260736 14264382 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01004005001 14260736 14264382 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01004005001 14260736 14264382 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01004005001 14260736 14264382 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01004005001 14260736 14264382 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01004005001 14260736 14264382 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01004005001 14260736 14264382 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01011666001 5390829 5401654 GSVIVG01034552001 19565382 19573457 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01034552001 19565382 19573457 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01007985001 6914852 6916706 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GSVIVG01027578001 15399528 15404025 GO:0006014 D-ribose metabolic process The chemical reactions and pathways involving D-ribose (ribo-pentose). As beta-D-ribofuranose, D-ribose forms the glycose moiety of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12. IEA Catalysis of the reaction: ATP + D-ribose = ADP + D-ribose 5-phosphate. IEA GO:0004747 ribokinase activity GSVIVG01027578001 15399528 15404025 GO:0006014 D-ribose metabolic process The chemical reactions and pathways involving D-ribose (ribo-pentose). As beta-D-ribofuranose, D-ribose forms the glycose moiety of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01027578001 15399528 15404025 GO:0006014 D-ribose metabolic process The chemical reactions and pathways involving D-ribose (ribo-pentose). As beta-D-ribofuranose, D-ribose forms the glycose moiety of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01006054001 23594600 23595215 GSVIVG01024592001 8584134 8585865 GSVIVG01012339001 458749 467269 GSVIVG01013642001 2047623 2049992 GSVIVG01019765001 3137803 3140804 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: 2 glutathione + H2O2 = oxidized glutathione + 2 H2O. IEA GO:0004602 glutathione peroxidase activity GSVIVG01019765001 3137803 3140804 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2 glutathione + H2O2 = oxidized glutathione + 2 H2O. IEA GO:0004602 glutathione peroxidase activity GSVIVG01019765001 3137803 3140804 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01019765001 3137803 3140804 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001819001 26071265 26073597 GSVIVG01025921001 27221408 27221909 GSVIVG01005101001 18099821 18100543 GSVIVG01036466001 22391427 22393505 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Catalysis of the endohydrolysis of 1,3- or 1,4-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolysed is itself substituted at C-3. IEA GO:0033903 endo-1,3(4)-beta-glucanase activity GSVIVG01031322001 371623 372796 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Stops, prevents or reduces the activity of an enzyme. IEA GO:0004857 enzyme inhibitor activity GSVIVG01031322001 371623 372796 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01031322001 371623 372796 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the reaction: pectin + n H2O = n methanol + pectate. IEA GO:0030599 pectinesterase activity GSVIVG01031322001 371623 372796 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue. IEA GO:0045330 aspartyl esterase activity GSVIVG01013389001 767918 780317 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01013389001 767918 780317 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate, driving the unwinding of the DNA helix. IEA GO:0004003 ATP-dependent DNA helicase activity GSVIVG01013389001 767918 780317 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013389001 767918 780317 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01013389001 767918 780317 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. IEA GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GSVIVG01020796001 1891867 1894974 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01025506001 247698 255256 GSVIVG01010858001 16789119 16789514 GSVIVG01007723001 9907478 9915574 GSVIVG01015430001 3603704 3604592 GSVIVG01022214001 17548419 17549294 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01022214001 17548419 17549294 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01022214001 17548419 17549294 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01022214001 17548419 17549294 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01009050001 4550436 4552363 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01002515001 35147569 35151791 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01002515001 35147569 35151791 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01002515001 35147569 35151791 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01003345001 9199740 9200694 GSVIVG01000111001 15348021 15351653 GO:0000103 sulfate assimilation The pathways by which inorganic sulfate is processed and incorporated into sulfated compounds. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000111001 15348021 15351653 GO:0000103 sulfate assimilation The pathways by which inorganic sulfate is processed and incorporated into sulfated compounds. IEA Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. IEA GO:0016301 kinase activity GSVIVG01000111001 15348021 15351653 GO:0000103 sulfate assimilation The pathways by which inorganic sulfate is processed and incorporated into sulfated compounds. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01035739001 3829577 3830913 GSVIVG01017274001 6247227 6261774 GSVIVG01021285001 3439036 3462765 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01021285001 3439036 3462765 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01021285001 3439036 3462765 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01021285001 3439036 3462765 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01021285001 3439036 3462765 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032743001 1101297 1101861 GO:0009611 response to wounding A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism. IEA Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme. IEA GO:0004867 serine-type endopeptidase inhibitor activity GSVIVG01000100001 3533076 3533905 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with manganese (Mn) ions. IEA GO:0030145 manganese ion binding GSVIVG01000100001 3533076 3533905 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Functions in the storage of nutritious substrates. IEA GO:0045735 nutrient reservoir activity GSVIVG01026337001 14264793 14265273 GSVIVG01032549001 28263547 28264531 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005578 proteinaceous extracellular matrix A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01032549001 28263547 28264531 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0031012 extracellular matrix A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as in plants). IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01032549001 28263547 28264531 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005578 proteinaceous extracellular matrix A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008237 metallopeptidase activity GSVIVG01032549001 28263547 28264531 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0031012 extracellular matrix A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as in plants). IEA Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008237 metallopeptidase activity GSVIVG01008141001 5431008 5432328 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA GSVIVG01035777001 4206514 4209963 GSVIVG01033986001 16097909 16102080 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01033986001 16097909 16102080 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01008676001 1136685 1144425 GSVIVG01036617001 19272333 19273328 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025457001 705627 713337 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0000808 origin recognition complex A multisubunit complex that is located at the replication origins of a chromosome. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025457001 705627 713337 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025457001 705627 713337 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0000808 origin recognition complex A multisubunit complex that is located at the replication origins of a chromosome. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025457001 705627 713337 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025457001 705627 713337 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0000808 origin recognition complex A multisubunit complex that is located at the replication origins of a chromosome. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025457001 705627 713337 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025457001 705627 713337 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0000808 origin recognition complex A multisubunit complex that is located at the replication origins of a chromosome. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01025457001 705627 713337 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01025457001 705627 713337 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0000808 origin recognition complex A multisubunit complex that is located at the replication origins of a chromosome. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01025457001 705627 713337 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01025120001 4259863 4262518 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01025120001 4259863 4262518 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01025120001 4259863 4262518 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015935 small ribosomal subunit The smaller of the two subunits of a ribosome. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01025120001 4259863 4262518 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01007958001 7163669 7183054 GO:0016043 cellular component organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cellular component. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01007958001 7163669 7183054 GO:0030036 actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01037542001 11742669 11747964 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01010731001 21880043 21882774 GSVIVG01027952001 9996138 10002158 GSVIVG01032008001 23596536 23603872 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032008001 23596536 23603872 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01032008001 23596536 23603872 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01030877001 18214601 18257683 GSVIVG01026083001 24811607 24818958 GSVIVG01007849001 8383025 8387816 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01007849001 8383025 8387816 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01017921001 4705770 4728522 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01017921001 4705770 4728522 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01017921001 4705770 4728522 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01017921001 4705770 4728522 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017921001 4705770 4728522 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01025314001 2120950 2125115 GSVIVG01006794001 252258 253652 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01019426001 584921 595743 GSVIVG01031372001 19447229 19451253 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01031372001 19447229 19451253 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01031372001 19447229 19451253 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01031372001 19447229 19451253 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010458001 20766415 20771154 GSVIVG01013980001 8404887 8405009 GSVIVG01008618001 364771 366466 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01008618001 364771 366466 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01003138001 7568684 7571407 GSVIVG01012012001 2197476 2202142 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01023162001 21774576 21778541 GSVIVG01021262001 3127668 3133724 GO:0006621 protein retention in ER lumen The retention in the endoplasmic reticulum (ER) lumen of soluble resident proteins. Sorting receptors retrieve proteins with ER localization signals, such as KDEL and HDEL sequences or some transmembrane domains, that have escaped to the cis-Golgi network and return them to the ER. Abnormally folded proteins and unassembled subunits are also selectively retained in the ER. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with an endoplasmic reticulum (ER) retention sequence, a specific peptide sequence that ensures a protein is retained within the ER. IEA GO:0046923 ER retention sequence binding GSVIVG01012646001 317863 328295 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01012646001 317863 328295 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01012646001 317863 328295 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01012646001 317863 328295 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01038397001 11743386 11744875 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01030977001 20172764 20176315 GSVIVG01024601001 8529499 8538801 GSVIVG01031328001 333747 335685 GSVIVG01003831001 20501172 20504073 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: 3-alpha(S)-strictosidine = tryptamine + secologanin. IEA GO:0016844 strictosidine synthase activity GSVIVG01023127001 22299473 22310405 GO:0006278 RNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01023127001 22299473 22310405 GO:0008380 RNA splicing The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01023127001 22299473 22310405 GO:0006278 RNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands. IEA Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time. IEA GO:0003964 RNA-directed DNA polymerase activity GSVIVG01023127001 22299473 22310405 GO:0008380 RNA splicing The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA. IEA Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time. IEA GO:0003964 RNA-directed DNA polymerase activity GSVIVG01012128001 1198056 1206373 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with transfer RNA. IEA GO:0000049 tRNA binding GSVIVG01012128001 1198056 1206373 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe). IEA GO:0004826 phenylalanine-tRNA ligase activity GSVIVG01012128001 1198056 1206373 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037051001 8350298 8352225 GSVIVG01032778001 822229 823785 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01032778001 822229 823785 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032778001 822229 823785 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032778001 822229 823785 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01020370001 20470930 20471341 GSVIVG01006789001 28526052 28527845 GSVIVG01018341001 10773614 10778176 GO:0005789 endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01021562001 7091569 7097924 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01004013001 1328850 1334085 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01004013001 1328850 1334085 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01004013001 1328850 1334085 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01004013001 1328850 1334085 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015673001 15345490 15354975 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01015673001 15345490 15354975 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01011772001 4278409 4287349 GSVIVG01021794001 7295617 7302465 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01022898001 18190766 18192607 Functions in the storage of nutritious substrates. IEA GO:0045735 nutrient reservoir activity GSVIVG01024138001 858886 859170 GSVIVG01028766001 19081475 19085375 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000664001 20537033 20541398 GSVIVG01021677001 9190056 9190808 GSVIVG01001790001 3218813 3228670 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01001790001 3218813 3228670 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01001790001 3218813 3228670 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01001790001 3218813 3228670 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01001790001 3218813 3228670 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01001790001 3218813 3228670 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01001790001 3218813 3228670 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01001790001 3218813 3228670 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01001790001 3218813 3228670 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01001790001 3218813 3228670 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01001790001 3218813 3228670 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01001790001 3218813 3228670 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01001790001 3218813 3228670 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001790001 3218813 3228670 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001790001 3218813 3228670 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001790001 3218813 3228670 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001790001 3218813 3228670 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01001790001 3218813 3228670 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01001790001 3218813 3228670 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01001790001 3218813 3228670 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01001790001 3218813 3228670 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01001790001 3218813 3228670 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01001790001 3218813 3228670 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01001790001 3218813 3228670 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01019504001 1184188 1187119 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01033076001 25568450 25572250 GSVIVG01003204001 7884877 7886357 GO:0009765 photosynthesis, light harvesting Absorption and transfer of the energy absorbed from light photons between photosystem reaction centers. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01023147001 21986920 21996449 GSVIVG01006619001 27097195 27101497 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01006619001 27097195 27101497 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01006619001 27097195 27101497 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01006619001 27097195 27101497 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01017020001 3485168 3497071 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017020001 3485168 3497071 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017020001 3485168 3497071 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017020001 3485168 3497071 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000086001 3325753 3327711 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01023944001 2267331 2269351 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0031227 intrinsic to endoplasmic reticulum membrane Located in the endoplasmic reticulum membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01023944001 2267331 2269351 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0031227 intrinsic to endoplasmic reticulum membrane Located in the endoplasmic reticulum membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01023944001 2267331 2269351 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0031227 intrinsic to endoplasmic reticulum membrane Located in the endoplasmic reticulum membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01001880001 6686803 6687828 GSVIVG01015545001 4715987 4723647 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01015545001 4715987 4723647 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01015545001 4715987 4723647 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01027997001 3096248 3100934 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01027997001 3096248 3100934 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01036128001 20359381 20362331 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01036128001 20359381 20362331 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01036128001 20359381 20362331 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01036128001 20359381 20362331 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01036128001 20359381 20362331 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01036128001 20359381 20362331 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01036128001 20359381 20362331 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01036128001 20359381 20362331 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01000468001 8231925 8262298 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01004796001 140185 142825 GSVIVG01028315001 6041362 6043169 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01028315001 6041362 6043169 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01015453001 3805724 3809557 GSVIVG01007997001 6803427 6806485 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007997001 6803427 6806485 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007997001 6803427 6806485 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007997001 6803427 6806485 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007997001 6803427 6806485 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007997001 6803427 6806485 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007997001 6803427 6806485 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01007997001 6803427 6806485 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01007997001 6803427 6806485 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01007997001 6803427 6806485 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01007997001 6803427 6806485 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01007997001 6803427 6806485 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01007997001 6803427 6806485 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01007997001 6803427 6806485 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01007997001 6803427 6806485 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01007997001 6803427 6806485 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01007997001 6803427 6806485 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01007997001 6803427 6806485 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01007997001 6803427 6806485 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. IEA GO:0016615 malate dehydrogenase activity GSVIVG01007997001 6803427 6806485 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. IEA GO:0016615 malate dehydrogenase activity GSVIVG01007997001 6803427 6806485 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. IEA GO:0016615 malate dehydrogenase activity GSVIVG01007997001 6803427 6806485 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. IEA GO:0016615 malate dehydrogenase activity GSVIVG01007997001 6803427 6806485 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. IEA GO:0016615 malate dehydrogenase activity GSVIVG01007997001 6803427 6806485 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. IEA GO:0016615 malate dehydrogenase activity GSVIVG01007997001 6803427 6806485 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01007997001 6803427 6806485 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01007997001 6803427 6806485 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01007997001 6803427 6806485 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01007997001 6803427 6806485 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01007997001 6803427 6806485 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01007997001 6803427 6806485 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids. IEA GO:0030060 L-malate dehydrogenase activity GSVIVG01007997001 6803427 6806485 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids. IEA GO:0030060 L-malate dehydrogenase activity GSVIVG01007997001 6803427 6806485 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids. IEA GO:0030060 L-malate dehydrogenase activity GSVIVG01007997001 6803427 6806485 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids. IEA GO:0030060 L-malate dehydrogenase activity GSVIVG01007997001 6803427 6806485 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids. IEA GO:0030060 L-malate dehydrogenase activity GSVIVG01007997001 6803427 6806485 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids. IEA GO:0030060 L-malate dehydrogenase activity GSVIVG01038380001 11483010 11502197 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015947001 16029491 16030398 GSVIVG01030140001 10189061 10194823 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01030140001 10189061 10194823 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01030140001 10189061 10194823 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01030140001 10189061 10194823 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01030140001 10189061 10194823 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01030140001 10189061 10194823 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030140001 10189061 10194823 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030140001 10189061 10194823 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030140001 10189061 10194823 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030140001 10189061 10194823 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030140001 10189061 10194823 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01030140001 10189061 10194823 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01030140001 10189061 10194823 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01030140001 10189061 10194823 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01030140001 10189061 10194823 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01035144001 1840343 1843831 GSVIVG01030553001 6691309 6697009 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026390001 15488628 15500451 GO:0009725 response to hormone stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01026390001 15488628 15500451 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01022264001 18003234 18004396 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01022264001 18003234 18004396 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01022264001 18003234 18004396 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01011780001 4209011 4214620 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar. IEA GO:0008375 acetylglucosaminyltransferase activity GSVIVG01020111001 10253870 10258080 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01020111001 10253870 10258080 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid. IEA GO:0008378 galactosyltransferase activity GSVIVG01037113001 29018757 29021753 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01030216001 10351579 10355690 GSVIVG01026636001 20861325 20865130 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01026636001 20861325 20865130 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01026636001 20861325 20865130 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01026636001 20861325 20865130 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01026636001 20861325 20865130 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01026636001 20861325 20865130 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01013893001 6264854 6273291 GSVIVG01000790001 182994 183785 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01013668001 2278719 2289222 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01013668001 2278719 2289222 Catalysis of the reaction: ATP + shikimate = ADP + shikimate 3-phosphate. IEA GO:0004765 shikimate kinase activity GSVIVG01013668001 2278719 2289222 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013668001 2278719 2289222 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01017052001 3805222 3809258 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01017052001 3805222 3809258 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01026850001 19980595 19986357 GSVIVG01009228001 6442873 6452788 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01009228001 6442873 6452788 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01009228001 6442873 6452788 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01009228001 6442873 6452788 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01009228001 6442873 6452788 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01009228001 6442873 6452788 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01009228001 6442873 6452788 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009228001 6442873 6452788 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000924001 21941247 21943211 GO:0006887 exocytosis A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell. This is the process whereby most molecules are secreted from eukaryotic cells. IEA GO:0000145 exocyst A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals. IEA GSVIVG01000924001 21941247 21943211 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0000145 exocyst A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals. IEA GSVIVG01033383001 21050134 21051743 GSVIVG01013451001 368569 375676 GSVIVG01000454001 8145853 8157823 GO:0006519 cellular amino acid and derivative metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000454001 8145853 8157823 GO:0019752 carboxylic acid metabolic process The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000454001 8145853 8157823 GO:0006519 cellular amino acid and derivative metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells. IEA Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. IEA GO:0016831 carboxy-lyase activity GSVIVG01000454001 8145853 8157823 GO:0019752 carboxylic acid metabolic process The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). IEA Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. IEA GO:0016831 carboxy-lyase activity GSVIVG01000454001 8145853 8157823 GO:0006519 cellular amino acid and derivative metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01000454001 8145853 8157823 GO:0019752 carboxylic acid metabolic process The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01007981001 6993893 6995184 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01017833001 3864995 3870165 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01017833001 3864995 3870165 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01018665001 11481262 11488666 GSVIVG01023490001 11049764 11050207 GSVIVG01015587001 5262579 5267042 The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01017074001 3998146 4001383 GSVIVG01038588001 21690987 21696151 GSVIVG01008953001 3798810 3803646 GSVIVG01016422001 4089631 4097825 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01025119001 4265254 4267206 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025119001 4265254 4267206 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01028059001 3499758 3505637 GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01031344001 172513 179496 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01031344001 172513 179496 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031344001 172513 179496 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids. IEA GO:0004518 nuclease activity GSVIVG01031344001 172513 179496 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 5' end. IEA GO:0008409 5'-3' exonuclease activity GSVIVG01035791001 4370044 4384297 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0000159 protein phosphatase type 2A complex A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035791001 4370044 4384297 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035791001 4370044 4384297 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0000159 protein phosphatase type 2A complex A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit. IEA Modulation of the activity of the enzyme protein phosphatase type 2A. IEA GO:0008601 protein phosphatase type 2A regulator activity GSVIVG01035791001 4370044 4384297 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Modulation of the activity of the enzyme protein phosphatase type 2A. IEA GO:0008601 protein phosphatase type 2A regulator activity GSVIVG01026876001 19702326 19707865 GSVIVG01010644001 15664173 15666476 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010644001 15664173 15666476 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010644001 15664173 15666476 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01010644001 15664173 15666476 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01010644001 15664173 15666476 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01010644001 15664173 15666476 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01010644001 15664173 15666476 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01010644001 15664173 15666476 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01009870001 11959701 11960404 GSVIVG01016862001 2069774 2075856 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016862001 2069774 2075856 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016862001 2069774 2075856 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016862001 2069774 2075856 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016862001 2069774 2075856 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016862001 2069774 2075856 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016862001 2069774 2075856 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016862001 2069774 2075856 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016862001 2069774 2075856 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016862001 2069774 2075856 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016862001 2069774 2075856 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016862001 2069774 2075856 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016862001 2069774 2075856 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016862001 2069774 2075856 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016862001 2069774 2075856 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016862001 2069774 2075856 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016862001 2069774 2075856 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005267 potassium channel activity GSVIVG01016862001 2069774 2075856 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005267 potassium channel activity GSVIVG01016862001 2069774 2075856 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005267 potassium channel activity GSVIVG01016862001 2069774 2075856 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005267 potassium channel activity GSVIVG01016862001 2069774 2075856 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005267 potassium channel activity GSVIVG01016862001 2069774 2075856 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005267 potassium channel activity GSVIVG01016862001 2069774 2075856 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005267 potassium channel activity GSVIVG01016862001 2069774 2075856 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005267 potassium channel activity GSVIVG01016862001 2069774 2075856 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016862001 2069774 2075856 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016862001 2069774 2075856 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016862001 2069774 2075856 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016862001 2069774 2075856 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016862001 2069774 2075856 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016862001 2069774 2075856 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016862001 2069774 2075856 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016862001 2069774 2075856 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01016862001 2069774 2075856 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01016862001 2069774 2075856 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01016862001 2069774 2075856 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01016862001 2069774 2075856 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01016862001 2069774 2075856 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01016862001 2069774 2075856 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01016862001 2069774 2075856 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01016862001 2069774 2075856 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01016862001 2069774 2075856 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01016862001 2069774 2075856 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01016862001 2069774 2075856 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01016862001 2069774 2075856 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01016862001 2069774 2075856 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01016862001 2069774 2075856 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01016862001 2069774 2075856 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01016862001 2069774 2075856 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01016862001 2069774 2075856 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01016862001 2069774 2075856 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01016862001 2069774 2075856 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01016862001 2069774 2075856 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01016862001 2069774 2075856 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01016862001 2069774 2075856 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01016862001 2069774 2075856 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01016862001 2069774 2075856 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01016862001 2069774 2075856 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01016862001 2069774 2075856 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01016862001 2069774 2075856 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01016862001 2069774 2075856 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01016862001 2069774 2075856 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01016862001 2069774 2075856 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01016862001 2069774 2075856 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01023693001 9416810 9433179 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035772001 4177697 4184300 GSVIVG01013290001 27350 34800 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01013290001 27350 34800 Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01009848001 11761770 11763902 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01009848001 11761770 11763902 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01009848001 11761770 11763902 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01009848001 11761770 11763902 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01011916001 3030505 3040686 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01011916001 3030505 3040686 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01011916001 3030505 3040686 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01011916001 3030505 3040686 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037425001 13976420 13977709 GSVIVG01031585001 18478181 18479876 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01003678001 12043083 12049506 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01003678001 12043083 12049506 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01037387001 14570869 14583926 GSVIVG01014095001 347976 351626 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: ATP + NAD+ = ADP + NADP+. IEA GO:0003951 NAD+ kinase activity GSVIVG01024396001 2068665 2075137 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA GSVIVG01013217001 6657871 6661876 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01013217001 6657871 6661876 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01024719001 7469237 7472914 GSVIVG01010758001 22272872 22332432 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01010758001 22272872 22332432 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01010758001 22272872 22332432 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01010758001 22272872 22332432 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01010758001 22272872 22332432 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01010758001 22272872 22332432 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01010758001 22272872 22332432 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01010758001 22272872 22332432 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01010758001 22272872 22332432 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010758001 22272872 22332432 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016193001 6843718 6848333 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. IEA GO:0016597 amino acid binding GSVIVG01011670001 5367648 5369179 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01011670001 5367648 5369179 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01023689001 9369631 9376110 GSVIVG01030439001 5560467 5566574 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: prephenate = phenylpyruvate + H2O + CO2. IEA GO:0004664 prephenate dehydratase activity GSVIVG01030439001 5560467 5566574 GO:0009094 L-phenylalanine biosynthetic process The chemical reactions and pathways resulting in the formation of L-phenylalanine, the L-enantiomer of 2-amino-3-phenylpropanoic acid, i.e. (2S)-2-amino-3-phenylpropanoic acid. IEA Catalysis of the reaction: prephenate = phenylpyruvate + H2O + CO2. IEA GO:0004664 prephenate dehydratase activity GSVIVG01030439001 5560467 5566574 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. IEA GO:0016597 amino acid binding GSVIVG01030439001 5560467 5566574 GO:0009094 L-phenylalanine biosynthetic process The chemical reactions and pathways resulting in the formation of L-phenylalanine, the L-enantiomer of 2-amino-3-phenylpropanoic acid, i.e. (2S)-2-amino-3-phenylpropanoic acid. IEA Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. IEA GO:0016597 amino acid binding GSVIVG01015735001 16640517 16642082 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01015735001 16640517 16642082 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01015735001 16640517 16642082 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01015735001 16640517 16642082 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01035253001 11443796 11463685 GSVIVG01025873001 10934029 10938673 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GSVIVG01028392001 7045523 7053384 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01022149001 16984098 16986176 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA GSVIVG01022149001 16984098 16986176 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GSVIVG01028491001 8378489 8382595 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01005730001 13887191 13893238 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01005730001 13887191 13893238 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: linoleate + O2 = (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate. IEA GO:0016165 lipoxygenase activity GSVIVG01005730001 13887191 13893238 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor. IEA GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen GSVIVG01005730001 13887191 13893238 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01011729001 4742694 4743585 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GSVIVG01011729001 4742694 4743585 GO:0009607 response to biotic stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism. IEA GSVIVG01017576001 10857491 10857658 GSVIVG01017906001 4531079 4532024 GSVIVG01019787001 3284195 3293203 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01019787001 3284195 3293203 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01019787001 3284195 3293203 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019787001 3284195 3293203 Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01033275001 21950723 21954138 GSVIVG01017107001 4202900 4204452 GSVIVG01035509001 1896543 1899020 GSVIVG01024750001 7235009 7239328 Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01017089001 4089906 4093765 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01017089001 4089906 4093765 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01017089001 4089906 4093765 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01017089001 4089906 4093765 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01017089001 4089906 4093765 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017089001 4089906 4093765 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017089001 4089906 4093765 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017089001 4089906 4093765 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01018804001 19719714 19723663 GSVIVG01019929001 4534193 4535347 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01036299001 3520520 3524104 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01036299001 3520520 3524104 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01036299001 3520520 3524104 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01036299001 3520520 3524104 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006902001 29000853 29002052 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01006902001 29000853 29002052 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038262001 24787599 24790547 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01038262001 24787599 24790547 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01038262001 24787599 24790547 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA Catalysis of the transfer of a nucleotidyl group to a reactant. IEA GO:0016779 nucleotidyltransferase activity GSVIVG01038262001 24787599 24790547 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nucleotidyl group to a reactant. IEA GO:0016779 nucleotidyltransferase activity GSVIVG01028129001 4044128 4045807 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01028129001 4044128 4045807 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01012184001 721721 725418 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01025051001 4995148 4997309 GO:0006887 exocytosis A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell. This is the process whereby most molecules are secreted from eukaryotic cells. IEA GO:0000145 exocyst A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals. IEA GSVIVG01005518001 40500749 40503367 GO:0009116 nucleoside metabolic process The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine). IEA GSVIVG01026586001 21371013 21372847 GSVIVG01017231001 5716073 5716365 GSVIVG01021135001 1742438 1744317 Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. IEA GO:0008171 O-methyltransferase activity GSVIVG01033256001 22138461 22148791 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: thioredoxin + NADP+ = thioredoxin disulfide + NADPH + H+. IEA GO:0004791 thioredoxin-disulfide reductase activity GSVIVG01033256001 22138461 22148791 GO:0019430 removal of superoxide radicals Any process involved in removing superoxide radicals (O2-) from a cell or organism, e.g. by conversion to dioxygen (O2) and hydrogen peroxide (H2O2). IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: thioredoxin + NADP+ = thioredoxin disulfide + NADPH + H+. IEA GO:0004791 thioredoxin-disulfide reductase activity GSVIVG01033256001 22138461 22148791 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: thioredoxin + NADP+ = thioredoxin disulfide + NADPH + H+. IEA GO:0004791 thioredoxin-disulfide reductase activity GSVIVG01033256001 22138461 22148791 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: thioredoxin + NADP+ = thioredoxin disulfide + NADPH + H+. IEA GO:0004791 thioredoxin-disulfide reductase activity GSVIVG01033256001 22138461 22148791 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01033256001 22138461 22148791 GO:0019430 removal of superoxide radicals Any process involved in removing superoxide radicals (O2-) from a cell or organism, e.g. by conversion to dioxygen (O2) and hydrogen peroxide (H2O2). IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01033256001 22138461 22148791 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01033256001 22138461 22148791 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01033256001 22138461 22148791 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01033256001 22138461 22148791 GO:0019430 removal of superoxide radicals Any process involved in removing superoxide radicals (O2-) from a cell or organism, e.g. by conversion to dioxygen (O2) and hydrogen peroxide (H2O2). IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01033256001 22138461 22148791 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01033256001 22138461 22148791 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01033256001 22138461 22148791 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds. IEA GO:0015035 protein disulfide oxidoreductase activity GSVIVG01033256001 22138461 22148791 GO:0019430 removal of superoxide radicals Any process involved in removing superoxide radicals (O2-) from a cell or organism, e.g. by conversion to dioxygen (O2) and hydrogen peroxide (H2O2). IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds. IEA GO:0015035 protein disulfide oxidoreductase activity GSVIVG01033256001 22138461 22148791 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds. IEA GO:0015035 protein disulfide oxidoreductase activity GSVIVG01033256001 22138461 22148791 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds. IEA GO:0015035 protein disulfide oxidoreductase activity GSVIVG01033256001 22138461 22148791 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033256001 22138461 22148791 GO:0019430 removal of superoxide radicals Any process involved in removing superoxide radicals (O2-) from a cell or organism, e.g. by conversion to dioxygen (O2) and hydrogen peroxide (H2O2). IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033256001 22138461 22148791 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033256001 22138461 22148791 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033256001 22138461 22148791 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01033256001 22138461 22148791 GO:0019430 removal of superoxide radicals Any process involved in removing superoxide radicals (O2-) from a cell or organism, e.g. by conversion to dioxygen (O2) and hydrogen peroxide (H2O2). IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01033256001 22138461 22148791 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01033256001 22138461 22148791 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01030129001 10110659 10113767 GSVIVG01020508001 18220089 18220624 GSVIVG01032685001 1553464 1557241 GO:0009813 flavonoid biosynthetic process The chemical reactions and pathways resulting in the formation of flavonoids, a group of phenolic derivatives containing a flavan skeleton. IEA The catalysis of certain rearrangements of a molecule to break or form a ring. IEA GO:0016872 intramolecular lyase activity GSVIVG01032685001 1553464 1557241 GO:0042398 cellular amino acid derivative biosynthetic process The chemical reactions and pathways resulting in the formation of compounds derived from amino acids, organic acids containing one or more amino substituents. IEA The catalysis of certain rearrangements of a molecule to break or form a ring. IEA GO:0016872 intramolecular lyase activity GSVIVG01032685001 1553464 1557241 GO:0009813 flavonoid biosynthetic process The chemical reactions and pathways resulting in the formation of flavonoids, a group of phenolic derivatives containing a flavan skeleton. IEA Catalysis of the reaction: a chalcone = a flavanone. IEA GO:0045430 chalcone isomerase activity GSVIVG01032685001 1553464 1557241 GO:0042398 cellular amino acid derivative biosynthetic process The chemical reactions and pathways resulting in the formation of compounds derived from amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the reaction: a chalcone = a flavanone. IEA GO:0045430 chalcone isomerase activity GSVIVG01015822001 17891888 17906378 GO:0016226 iron-sulfur cluster assembly The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014783001 9659262 9673621 GSVIVG01035042001 1115775 1121049 GSVIVG01016126001 19503441 19507055 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01016126001 19503441 19507055 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01016126001 19503441 19507055 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01016126001 19503441 19507055 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016126001 19503441 19507055 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021104001 1477779 1481098 GSVIVG01016323001 5107954 5114881 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016323001 5107954 5114881 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016323001 5107954 5114881 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016323001 5107954 5114881 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016323001 5107954 5114881 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01016323001 5107954 5114881 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01016323001 5107954 5114881 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01016323001 5107954 5114881 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01016157001 20055599 20056137 GSVIVG01006465001 26189447 26190327 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01036392001 4567582 4568841 GSVIVG01034834001 22395059 22396523 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01034350001 17699853 17707424 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01034350001 17699853 17707424 GO:0009107 lipoate biosynthetic process The chemical reactions and pathways resulting in the formation of lipoate, 1,2-dithiolane-3-pentanoate, the anion derived from lipoic acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01034350001 17699853 17707424 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: protein N6-(octanoyl)lysine + 2 sulfur + 2 S-adenosyl-L-methionine = protein N6-(lipoyl)lysine + 2 L-methionine + 2 5'-deoxyadenosyl. IEA GO:0016992 lipoate synthase activity GSVIVG01034350001 17699853 17707424 GO:0009107 lipoate biosynthetic process The chemical reactions and pathways resulting in the formation of lipoate, 1,2-dithiolane-3-pentanoate, the anion derived from lipoic acid. IEA Catalysis of the reaction: protein N6-(octanoyl)lysine + 2 sulfur + 2 S-adenosyl-L-methionine = protein N6-(lipoyl)lysine + 2 L-methionine + 2 5'-deoxyadenosyl. IEA GO:0016992 lipoate synthase activity GSVIVG01034350001 17699853 17707424 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01034350001 17699853 17707424 GO:0009107 lipoate biosynthetic process The chemical reactions and pathways resulting in the formation of lipoate, 1,2-dithiolane-3-pentanoate, the anion derived from lipoic acid. IEA Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01034350001 17699853 17707424 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051539 4 iron, 4 sulfur cluster binding GSVIVG01034350001 17699853 17707424 GO:0009107 lipoate biosynthetic process The chemical reactions and pathways resulting in the formation of lipoate, 1,2-dithiolane-3-pentanoate, the anion derived from lipoic acid. IEA Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051539 4 iron, 4 sulfur cluster binding GSVIVG01031808001 4593424 4601048 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031808001 4593424 4601048 GO:0006526 arginine biosynthetic process The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031808001 4593424 4601048 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031808001 4593424 4601048 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031808001 4593424 4601048 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031808001 4593424 4601048 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH + H+. IEA GO:0003942 N-acetyl-gamma-glutamyl-phosphate reductase activity GSVIVG01031808001 4593424 4601048 GO:0006526 arginine biosynthetic process The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH + H+. IEA GO:0003942 N-acetyl-gamma-glutamyl-phosphate reductase activity GSVIVG01031808001 4593424 4601048 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH + H+. IEA GO:0003942 N-acetyl-gamma-glutamyl-phosphate reductase activity GSVIVG01031808001 4593424 4601048 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH + H+. IEA GO:0003942 N-acetyl-gamma-glutamyl-phosphate reductase activity GSVIVG01031808001 4593424 4601048 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH + H+. IEA GO:0003942 N-acetyl-gamma-glutamyl-phosphate reductase activity GSVIVG01031808001 4593424 4601048 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031808001 4593424 4601048 GO:0006526 arginine biosynthetic process The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031808001 4593424 4601048 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031808001 4593424 4601048 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031808001 4593424 4601048 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031808001 4593424 4601048 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031808001 4593424 4601048 GO:0006526 arginine biosynthetic process The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031808001 4593424 4601048 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031808001 4593424 4601048 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031808001 4593424 4601048 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01031808001 4593424 4601048 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. IEA GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor GSVIVG01031808001 4593424 4601048 GO:0006526 arginine biosynthetic process The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. IEA GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor GSVIVG01031808001 4593424 4601048 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. IEA GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor GSVIVG01031808001 4593424 4601048 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. IEA GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor GSVIVG01031808001 4593424 4601048 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. IEA GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor GSVIVG01031808001 4593424 4601048 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01031808001 4593424 4601048 GO:0006526 arginine biosynthetic process The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01031808001 4593424 4601048 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01031808001 4593424 4601048 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01031808001 4593424 4601048 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01031808001 4593424 4601048 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01031808001 4593424 4601048 GO:0006526 arginine biosynthetic process The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01031808001 4593424 4601048 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01031808001 4593424 4601048 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01031808001 4593424 4601048 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01010884001 16408073 16408367 GSVIVG01001165001 1125463 1127085 GSVIVG01005341001 39818196 39820677 GSVIVG01036177001 19774657 19776381 GSVIVG01018345001 10742664 10755774 GSVIVG01004938001 21672318 21676640 GSVIVG01012555001 3553610 3555769 GSVIVG01021542001 6849806 6860505 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01011812001 3909008 3915680 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01011812001 3909008 3915680 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01011812001 3909008 3915680 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. IEA GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GSVIVG01011812001 3909008 3915680 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species. IEA GO:0031418 L-ascorbic acid binding GSVIVG01019682001 2430222 2430832 GSVIVG01023829001 3154244 3156674 GSVIVG01032908001 23993049 23996880 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01032908001 23993049 23996880 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01032908001 23993049 23996880 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01032908001 23993049 23996880 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032908001 23993049 23996880 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009491001 8815129 8830854 GSVIVG01011273001 10370136 10379984 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01014221001 1629917 1636613 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014221001 1629917 1636613 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014221001 1629917 1636613 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014221001 1629917 1636613 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01004734001 15649286 15649561 GSVIVG01006476001 26304791 26320891 GSVIVG01024699001 7629238 7642019 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024699001 7629238 7642019 GO:0006000 fructose metabolic process The chemical reactions and pathways involving fructose, the ketohexose arabino-2-hexulose. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024699001 7629238 7642019 GO:0006003 fructose 2,6-bisphosphate metabolic process The chemical reactions and pathways involving fructose 2,6-bisphosphate. The D enantiomer is an important regulator of the glycolytic and gluconeogenic pathways. It inhibits fructose 1,6-bisphosphatase and activates phosphofructokinase. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024699001 7629238 7642019 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024699001 7629238 7642019 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: ATP + D-fructose 6-phosphate = ADP + D-fructose 2,6-bisphosphate. IEA GO:0003873 6-phosphofructo-2-kinase activity GSVIVG01024699001 7629238 7642019 GO:0006000 fructose metabolic process The chemical reactions and pathways involving fructose, the ketohexose arabino-2-hexulose. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey. IEA Catalysis of the reaction: ATP + D-fructose 6-phosphate = ADP + D-fructose 2,6-bisphosphate. IEA GO:0003873 6-phosphofructo-2-kinase activity GSVIVG01024699001 7629238 7642019 GO:0006003 fructose 2,6-bisphosphate metabolic process The chemical reactions and pathways involving fructose 2,6-bisphosphate. The D enantiomer is an important regulator of the glycolytic and gluconeogenic pathways. It inhibits fructose 1,6-bisphosphatase and activates phosphofructokinase. IEA Catalysis of the reaction: ATP + D-fructose 6-phosphate = ADP + D-fructose 2,6-bisphosphate. IEA GO:0003873 6-phosphofructo-2-kinase activity GSVIVG01024699001 7629238 7642019 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: ATP + D-fructose 6-phosphate = ADP + D-fructose 2,6-bisphosphate. IEA GO:0003873 6-phosphofructo-2-kinase activity GSVIVG01024699001 7629238 7642019 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024699001 7629238 7642019 GO:0006000 fructose metabolic process The chemical reactions and pathways involving fructose, the ketohexose arabino-2-hexulose. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024699001 7629238 7642019 GO:0006003 fructose 2,6-bisphosphate metabolic process The chemical reactions and pathways involving fructose 2,6-bisphosphate. The D enantiomer is an important regulator of the glycolytic and gluconeogenic pathways. It inhibits fructose 1,6-bisphosphatase and activates phosphofructokinase. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024699001 7629238 7642019 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024699001 7629238 7642019 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01024699001 7629238 7642019 GO:0006000 fructose metabolic process The chemical reactions and pathways involving fructose, the ketohexose arabino-2-hexulose. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey. IEA Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01024699001 7629238 7642019 GO:0006003 fructose 2,6-bisphosphate metabolic process The chemical reactions and pathways involving fructose 2,6-bisphosphate. The D enantiomer is an important regulator of the glycolytic and gluconeogenic pathways. It inhibits fructose 1,6-bisphosphatase and activates phosphofructokinase. IEA Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01024699001 7629238 7642019 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01014936001 12341046 12371576 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001604001 18346656 18351161 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01001604001 18346656 18351161 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01001604001 18346656 18351161 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01001604001 18346656 18351161 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01001604001 18346656 18351161 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001604001 18346656 18351161 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01023936001 2338609 2344688 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA GSVIVG01021813001 7036356 7048415 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033878001 17069109 17073262 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain. IEA GO:0004177 aminopeptidase activity GSVIVG01024480001 3114185 3114727 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024480001 3114185 3114727 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01015957001 16161255 16164545 GSVIVG01019587001 1788234 1792130 GSVIVG01011833001 3776554 3777948 GSVIVG01008133001 5513955 5516946 GO:0007047 cellular cell wall organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA Catalysis of the reaction: UDP-glucose + glycogenin = UDP + glucosylglycogenin. IEA GO:0008466 glycogenin glucosyltransferase activity GSVIVG01008133001 5513955 5516946 GO:0007047 cellular cell wall organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. IEA GO:0009505 plant-type cell wall A more or less rigid stucture lying outside the cell membrane of a cell and composed of cellulose and pectin and other organic and inorganic substances. IEA Catalysis of the reaction: UDP-glucose + glycogenin = UDP + glucosylglycogenin. IEA GO:0008466 glycogenin glucosyltransferase activity GSVIVG01008133001 5513955 5516946 GO:0007047 cellular cell wall organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. IEA GO:0030054 cell junction A plasma membrane part that forms a specialized region of connection between two cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix. IEA Catalysis of the reaction: UDP-glucose + glycogenin = UDP + glucosylglycogenin. IEA GO:0008466 glycogenin glucosyltransferase activity GSVIVG01008133001 5513955 5516946 GO:0030244 cellulose biosynthetic process The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA Catalysis of the reaction: UDP-glucose + glycogenin = UDP + glucosylglycogenin. IEA GO:0008466 glycogenin glucosyltransferase activity GSVIVG01008133001 5513955 5516946 GO:0030244 cellulose biosynthetic process The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation. IEA GO:0009505 plant-type cell wall A more or less rigid stucture lying outside the cell membrane of a cell and composed of cellulose and pectin and other organic and inorganic substances. IEA Catalysis of the reaction: UDP-glucose + glycogenin = UDP + glucosylglycogenin. IEA GO:0008466 glycogenin glucosyltransferase activity GSVIVG01008133001 5513955 5516946 GO:0030244 cellulose biosynthetic process The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation. IEA GO:0030054 cell junction A plasma membrane part that forms a specialized region of connection between two cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix. IEA Catalysis of the reaction: UDP-glucose + glycogenin = UDP + glucosylglycogenin. IEA GO:0008466 glycogenin glucosyltransferase activity GSVIVG01008133001 5513955 5516946 GO:0007047 cellular cell wall organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01008133001 5513955 5516946 GO:0007047 cellular cell wall organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. IEA GO:0009505 plant-type cell wall A more or less rigid stucture lying outside the cell membrane of a cell and composed of cellulose and pectin and other organic and inorganic substances. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01008133001 5513955 5516946 GO:0007047 cellular cell wall organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. IEA GO:0030054 cell junction A plasma membrane part that forms a specialized region of connection between two cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01008133001 5513955 5516946 GO:0030244 cellulose biosynthetic process The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation. IEA GO:0005794 Golgi apparatus A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01008133001 5513955 5516946 GO:0030244 cellulose biosynthetic process The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation. IEA GO:0009505 plant-type cell wall A more or less rigid stucture lying outside the cell membrane of a cell and composed of cellulose and pectin and other organic and inorganic substances. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01008133001 5513955 5516946 GO:0030244 cellulose biosynthetic process The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation. IEA GO:0030054 cell junction A plasma membrane part that forms a specialized region of connection between two cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01002212001 33407850 33413551 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01002212001 33407850 33413551 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01002212001 33407850 33413551 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01002212001 33407850 33413551 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029417001 16993809 16994813 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028853001 18064705 18071828 GSVIVG01012433001 733291 733617 GSVIVG01037962001 11714835 11715572 GSVIVG01030965001 19851162 19852479 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with manganese (Mn) ions. IEA GO:0030145 manganese ion binding GSVIVG01030965001 19851162 19852479 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Functions in the storage of nutritious substrates. IEA GO:0045735 nutrient reservoir activity GSVIVG01030965001 19851162 19852479 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01019923001 4494718 4500715 GSVIVG01034160001 14760421 14764336 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01004086001 14695681 14702602 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01018521001 13850726 13855632 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01031374001 19430381 19440652 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031374001 19430381 19440652 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA Catalysis of the hydrolysis of (1,6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin. Limit dextrin is the highly branched core that remains after exhaustive treatment of glycogen with glycogen phosphorylase. It is formed because these enzymes cannot hydrolyze the 1,6 glycosidic linkages present. IEA GO:0004135 amylo-alpha-1,6-glucosidase activity GSVIVG01010033001 13667828 13671320 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004185 serine-type carboxypeptidase activity GSVIVG01016139001 19612400 19623383 GO:0009274 peptidoglycan-based cell wall A protective structure outside the cytoplasmic membrane composed of peptidoglycan (also known as murein), a molecule made up of a glycan (sugar) backbone of repetitively alternating N-acetylglucosamine and N-acetylmuramic acid with short, attached, cross-linked peptide chains containing unusual amino acids. An example of this component is found in Escherichia coli. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01016139001 19612400 19623383 GO:0030115 S-layer A crystalline protein layer surrounding some bacteria. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01016139001 19612400 19623383 GO:0009274 peptidoglycan-based cell wall A protective structure outside the cytoplasmic membrane composed of peptidoglycan (also known as murein), a molecule made up of a glycan (sugar) backbone of repetitively alternating N-acetylglucosamine and N-acetylmuramic acid with short, attached, cross-linked peptide chains containing unusual amino acids. An example of this component is found in Escherichia coli. IEA The action of a molecule that contributes to the structural integrity of a cell wall. IEA GO:0005199 structural constituent of cell wall GSVIVG01016139001 19612400 19623383 GO:0030115 S-layer A crystalline protein layer surrounding some bacteria. IEA The action of a molecule that contributes to the structural integrity of a cell wall. IEA GO:0005199 structural constituent of cell wall GSVIVG01005047001 17680122 17684607 GSVIVG01024662001 7971774 7972539 GSVIVG01037385001 14593467 14599481 GSVIVG01015897001 19047096 19048349 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01019174001 4088008 4090031 GSVIVG01014724001 8994627 8997460 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GSVIVG01007286001 31305797 31307253 The action of a molecule that contributes to the structural integrity of a cell wall. IEA GO:0005199 structural constituent of cell wall GSVIVG01038594001 21621091 21623248 GSVIVG01007969001 7071258 7071532 GSVIVG01011206001 9457392 9459909 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01035502001 1834172 1834747 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035502001 1834172 1834747 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01006004001 24372628 24391067 GO:0016459 myosin complex A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01006004001 24372628 24391067 GO:0016459 myosin complex A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. IEA Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate. IEA GO:0003774 motor activity GSVIVG01006004001 24372628 24391067 GO:0016459 myosin complex A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006004001 24372628 24391067 GO:0016459 myosin complex A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01007625001 11125691 11128290 GSVIVG01010010001 13430850 13443079 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01010010001 13430850 13443079 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01030398001 5227499 5229003 GO:0051090 regulation of transcription factor activity Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Functions to initiate or regulate RNA polymerase II transcription. IEA GO:0003702 RNA polymerase II transcription factor activity GSVIVG01030398001 5227499 5229003 GO:0051090 regulation of transcription factor activity Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA IEA GO:0016986 transcription initiation factor activity GSVIVG01009628001 10033200 10037422 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01009628001 10033200 10037422 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01009628001 10033200 10037422 GO:0009245 lipid A biosynthetic process The chemical reactions and pathways resulting in the formation of lipid A, the glycolipid moiety of bacterial lipopolysaccharides, consisting of six fatty acyl chains linked to two glucosamine residues. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01009628001 10033200 10037422 GO:0009245 lipid A biosynthetic process The chemical reactions and pathways resulting in the formation of lipid A, the glycolipid moiety of bacterial lipopolysaccharides, consisting of six fatty acyl chains linked to two glucosamine residues. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01009628001 10033200 10037422 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the removal of an acetyl moiety from the 2-N position of glucosamine in the lipid A precursor UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine. IEA GO:0008759 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity GSVIVG01009628001 10033200 10037422 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Catalysis of the removal of an acetyl moiety from the 2-N position of glucosamine in the lipid A precursor UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine. IEA GO:0008759 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity GSVIVG01009628001 10033200 10037422 GO:0009245 lipid A biosynthetic process The chemical reactions and pathways resulting in the formation of lipid A, the glycolipid moiety of bacterial lipopolysaccharides, consisting of six fatty acyl chains linked to two glucosamine residues. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the removal of an acetyl moiety from the 2-N position of glucosamine in the lipid A precursor UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine. IEA GO:0008759 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity GSVIVG01009628001 10033200 10037422 GO:0009245 lipid A biosynthetic process The chemical reactions and pathways resulting in the formation of lipid A, the glycolipid moiety of bacterial lipopolysaccharides, consisting of six fatty acyl chains linked to two glucosamine residues. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Catalysis of the removal of an acetyl moiety from the 2-N position of glucosamine in the lipid A precursor UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine. IEA GO:0008759 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity GSVIVG01024787001 6947776 6949868 GSVIVG01033739001 18215450 18217141 GSVIVG01036083001 20880468 20915131 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01036083001 20880468 20915131 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA A ligand-dependent receptor found in the nucleus of the cell. IEA GO:0004879 ligand-dependent nuclear receptor activity GSVIVG01018534001 13715872 13716674 GSVIVG01030354001 4936412 4940993 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030354001 4936412 4940993 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). IEA GO:0016769 transferase activity, transferring nitrogenous groups GSVIVG01030354001 4936412 4940993 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01036950001 17048305 17049219 GSVIVG01012384001 304323 307937 GSVIVG01034232001 13178377 13179194 GSVIVG01014417001 3579039 3581410 GSVIVG01030205001 10460853 10467862 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01030205001 10460853 10467862 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01035277001 11866092 11879225 Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01034528001 19866886 19871844 GSVIVG01024246001 168012 174610 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024246001 168012 174610 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024246001 168012 174610 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024246001 168012 174610 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024246001 168012 174610 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01024246001 168012 174610 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01024246001 168012 174610 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024246001 168012 174610 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01010992001 2378724 2379712 GSVIVG01015126001 1242232 1243240 GSVIVG01036702001 23626248 23627989 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004197 cysteine-type endopeptidase activity GSVIVG01028253001 4961786 4967129 GSVIVG01034869001 14802635 14803924 GSVIVG01033113001 25824793 25826034 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036734001 23194272 23195684 GO:0006829 zinc ion transport The directed movement of zinc (Zn) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. IEA GO:0005385 zinc ion transmembrane transporter activity GSVIVG01036734001 23194272 23195684 GO:0006829 zinc ion transport The directed movement of zinc (Zn) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. IEA GO:0005385 zinc ion transmembrane transporter activity GSVIVG01036734001 23194272 23195684 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. IEA GO:0005385 zinc ion transmembrane transporter activity GSVIVG01036734001 23194272 23195684 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. IEA GO:0005385 zinc ion transmembrane transporter activity GSVIVG01036734001 23194272 23195684 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. IEA GO:0005385 zinc ion transmembrane transporter activity GSVIVG01036734001 23194272 23195684 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other. IEA GO:0005385 zinc ion transmembrane transporter activity GSVIVG01036734001 23194272 23195684 GO:0006829 zinc ion transport The directed movement of zinc (Zn) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01036734001 23194272 23195684 GO:0006829 zinc ion transport The directed movement of zinc (Zn) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01036734001 23194272 23195684 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01036734001 23194272 23195684 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01036734001 23194272 23195684 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01036734001 23194272 23195684 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of metal ions from one side of a membrane to the other. IEA GO:0046873 metal ion transmembrane transporter activity GSVIVG01009150001 5554568 5565201 GSVIVG01011071001 1818212 1820417 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01023299001 19962484 19963789 GSVIVG01009742001 10905271 10906291 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009742001 10905271 10906291 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01009387001 7935645 7940529 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01011809001 3945266 3976762 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01011809001 3945266 3976762 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01011809001 3945266 3976762 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01011809001 3945266 3976762 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with double-stranded RNA. IEA GO:0003725 double-stranded RNA binding GSVIVG01011809001 3945266 3976762 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01011809001 3945266 3976762 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011809001 3945266 3976762 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01011809001 3945266 3976762 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01031792001 4415091 4420009 GSVIVG01009717001 10724333 10746287 GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA GSVIVG01013613001 1499659 1510583 GSVIVG01006315001 24826985 24845829 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01006315001 24826985 24845829 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01006315001 24826985 24845829 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01006315001 24826985 24845829 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01006315001 24826985 24845829 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01006315001 24826985 24845829 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01006315001 24826985 24845829 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006315001 24826985 24845829 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006315001 24826985 24845829 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01006315001 24826985 24845829 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01018671001 11342603 11344045 GSVIVG01037060001 8244780 8251952 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01037060001 8244780 8251952 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01020962001 16286360 16290283 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020962001 16286360 16290283 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020962001 16286360 16290283 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020962001 16286360 16290283 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032826001 461755 462552 GSVIVG01029771001 14448034 14449637 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01029771001 14448034 14449637 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01029771001 14448034 14449637 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01029771001 14448034 14449637 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01017018001 3480319 3482039 GSVIVG01015314001 2599911 2615072 GSVIVG01000995001 11238835 11241274 GSVIVG01031632001 19249664 19262384 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01017642001 2215301 2216352 GSVIVG01010889001 16246446 16250586 GSVIVG01024222001 78495 94105 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01024222001 78495 94105 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01013379001 827872 829569 GSVIVG01000134001 15562917 15568566 GSVIVG01018067001 6187479 6188292 GSVIVG01027253001 17562765 17562905 GSVIVG01008777001 1877361 1894797 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01008777001 1877361 1894797 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01008777001 1877361 1894797 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01008777001 1877361 1894797 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008463001 1717077 1718118 GSVIVG01017504001 9555151 9556326 GSVIVG01011346001 28844329 28850603 GO:0006820 anion transport The directed movement of anions, atoms or small molecules with a net negative charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005741 mitochondrial outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope. IEA Catalysis of the transmembrane transfer of an anion by a voltage-gated channel. An anion is a negatively charged ion. IEA GO:0008308 voltage-gated anion channel activity GSVIVG01011346001 28844329 28850603 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005741 mitochondrial outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope. IEA Catalysis of the transmembrane transfer of an anion by a voltage-gated channel. An anion is a negatively charged ion. IEA GO:0008308 voltage-gated anion channel activity GSVIVG01037683001 6844614 6858752 GO:0000105 histidine biosynthetic process The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: phosphoribulosylformimino-AICAR-P + L-glutamine = D-erythro-imidazole-glycerol-phosphate + aminoimidazole carboxamide ribonucleotide + L-glutamate + 2 H+. IEA GO:0000107 imidazoleglycerol-phosphate synthase activity GSVIVG01037683001 6844614 6858752 GO:0006541 glutamine metabolic process The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: phosphoribulosylformimino-AICAR-P + L-glutamine = D-erythro-imidazole-glycerol-phosphate + aminoimidazole carboxamide ribonucleotide + L-glutamate + 2 H+. IEA GO:0000107 imidazoleglycerol-phosphate synthase activity GSVIVG01037683001 6844614 6858752 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: phosphoribulosylformimino-AICAR-P + L-glutamine = D-erythro-imidazole-glycerol-phosphate + aminoimidazole carboxamide ribonucleotide + L-glutamate + 2 H+. IEA GO:0000107 imidazoleglycerol-phosphate synthase activity GSVIVG01037683001 6844614 6858752 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: phosphoribulosylformimino-AICAR-P + L-glutamine = D-erythro-imidazole-glycerol-phosphate + aminoimidazole carboxamide ribonucleotide + L-glutamate + 2 H+. IEA GO:0000107 imidazoleglycerol-phosphate synthase activity GSVIVG01037683001 6844614 6858752 GO:0009236 cobalamin biosynthetic process The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: phosphoribulosylformimino-AICAR-P + L-glutamine = D-erythro-imidazole-glycerol-phosphate + aminoimidazole carboxamide ribonucleotide + L-glutamate + 2 H+. IEA GO:0000107 imidazoleglycerol-phosphate synthase activity GSVIVG01037683001 6844614 6858752 GO:0000105 histidine biosynthetic process The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01037683001 6844614 6858752 GO:0006541 glutamine metabolic process The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01037683001 6844614 6858752 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01037683001 6844614 6858752 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01037683001 6844614 6858752 GO:0009236 cobalamin biosynthetic process The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01037683001 6844614 6858752 GO:0000105 histidine biosynthetic process The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor). IEA GO:0016763 transferase activity, transferring pentosyl groups GSVIVG01037683001 6844614 6858752 GO:0006541 glutamine metabolic process The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor). IEA GO:0016763 transferase activity, transferring pentosyl groups GSVIVG01037683001 6844614 6858752 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor). IEA GO:0016763 transferase activity, transferring pentosyl groups GSVIVG01037683001 6844614 6858752 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor). IEA GO:0016763 transferase activity, transferring pentosyl groups GSVIVG01037683001 6844614 6858752 GO:0009236 cobalamin biosynthetic process The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor). IEA GO:0016763 transferase activity, transferring pentosyl groups GSVIVG01025025001 5187553 5188370 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025025001 5187553 5188370 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019099001 16755874 16756164 GSVIVG01016029001 17619325 17622068 GSVIVG01017376001 7531428 7544764 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032518001 28039386 28040937 GO:0016070 RNA metabolic process The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01011252001 10138889 10145712 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01011252001 10138889 10145712 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01012421001 609762 612682 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01012421001 609762 612682 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01012421001 609762 612682 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012421001 609762 612682 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01012421001 609762 612682 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012421001 609762 612682 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012421001 609762 612682 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01012421001 609762 612682 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01032177001 21803551 21804002 GSVIVG01031298001 564029 565883 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01027031001 18479238 18484958 GSVIVG01011891001 3246723 3249702 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01011891001 3246723 3249702 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01011891001 3246723 3249702 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015934 large ribosomal subunit The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01026373001 15225724 15228203 GSVIVG01011881001 3332313 3333709 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA GSVIVG01032610001 28805445 28808672 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01032610001 28805445 28808672 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01032610001 28805445 28808672 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01032610001 28805445 28808672 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032610001 28805445 28808672 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009103001 5058487 5059001 GSVIVG01029073001 11894248 11921267 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029073001 11894248 11921267 GO:0009082 branched chain family amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029073001 11894248 11921267 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O. IEA GO:0004160 dihydroxy-acid dehydratase activity GSVIVG01029073001 11894248 11921267 GO:0009082 branched chain family amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. IEA Catalysis of the reaction: 2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O. IEA GO:0004160 dihydroxy-acid dehydratase activity GSVIVG01019461001 835067 838279 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01026291001 12797955 12843528 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013190001 6931447 6937802 GSVIVG01029114001 19498427 19505907 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01029114001 19498427 19505907 GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01029114001 19498427 19505907 GO:0042732 D-xylose metabolic process The chemical reactions and pathways involving D-xylose, a naturally occurring plant polysaccharide. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01029114001 19498427 19505907 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: D-xylose = D-xylulose. IEA GO:0009045 xylose isomerase activity GSVIVG01029114001 19498427 19505907 GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: D-xylose = D-xylulose. IEA GO:0009045 xylose isomerase activity GSVIVG01029114001 19498427 19505907 GO:0042732 D-xylose metabolic process The chemical reactions and pathways involving D-xylose, a naturally occurring plant polysaccharide. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: D-xylose = D-xylulose. IEA GO:0009045 xylose isomerase activity GSVIVG01029114001 19498427 19505907 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. IEA GO:0016853 isomerase activity GSVIVG01029114001 19498427 19505907 GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. IEA GO:0016853 isomerase activity GSVIVG01029114001 19498427 19505907 GO:0042732 D-xylose metabolic process The chemical reactions and pathways involving D-xylose, a naturally occurring plant polysaccharide. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. IEA GO:0016853 isomerase activity GSVIVG01029114001 19498427 19505907 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01029114001 19498427 19505907 GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01029114001 19498427 19505907 GO:0042732 D-xylose metabolic process The chemical reactions and pathways involving D-xylose, a naturally occurring plant polysaccharide. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01038193001 24241166 24249599 GSVIVG01035133001 1730894 1734419 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01021155001 1941762 1943461 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01021155001 1941762 1943461 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01021155001 1941762 1943461 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01021155001 1941762 1943461 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01021155001 1941762 1943461 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01021155001 1941762 1943461 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01030252001 9854451 9859899 GSVIVG01009448001 8465118 8469528 GO:0019941 modification-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01009448001 8465118 8469528 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01009448001 8465118 8469528 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01009448001 8465118 8469528 GO:0019941 modification-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01009448001 8465118 8469528 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01009448001 8465118 8469528 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01015202001 1796783 1800464 GSVIVG01033029001 25189642 25192568 Catalysis of the reaction: ATP + shikimate = ADP + shikimate 3-phosphate. IEA GO:0004765 shikimate kinase activity GSVIVG01033029001 25189642 25192568 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007978001 7027585 7031512 GO:0042546 cell wall biogenesis The process by which a cell wall is synthesized, aggregates, and bonds together. Includes biosynthesis of constituent macromolecules, such as proteins and polysaccharides, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component. A cell wall is the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: GDP-L-fucose + beta-D-galactosyl-R = GDP + alpha-L-fucosyl-(1,2)-beta-D-galactosyl-R. IEA GO:0008107 galactoside 2-alpha-L-fucosyltransferase activity GSVIVG01003194001 7763576 7770277 GSVIVG01007682001 10483810 10491369 GO:0007160 cell-matrix adhesion The binding of a cell to the extracellular matrix via adhesion molecules. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01007682001 10483810 10491369 GO:0007160 cell-matrix adhesion The binding of a cell to the extracellular matrix via adhesion molecules. IEA GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01035386001 931995 932896 GSVIVG01031081001 2509561 2512096 GSVIVG01028270001 5053746 5060038 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA Catalysis of the reaction: ATP + alpha-D-glucose 1-phosphate = diphosphate + ADP-glucose. IEA GO:0008878 glucose-1-phosphate adenylyltransferase activity GSVIVG01028270001 5053746 5060038 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: ATP + alpha-D-glucose 1-phosphate = diphosphate + ADP-glucose. IEA GO:0008878 glucose-1-phosphate adenylyltransferase activity GSVIVG01028270001 5053746 5060038 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA Catalysis of the transfer of a nucleotidyl group to a reactant. IEA GO:0016779 nucleotidyltransferase activity GSVIVG01028270001 5053746 5060038 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nucleotidyl group to a reactant. IEA GO:0016779 nucleotidyltransferase activity GSVIVG01012074001 1623155 1631283 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01017727001 2962423 2970890 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01017727001 2962423 2970890 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010284001 19042623 19048171 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008962001 3879307 3882855 GSVIVG01003640001 11418267 11431667 GSVIVG01000273001 20920012 20930048 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01009167001 5674196 5679787 GSVIVG01020080001 10593200 10594374 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020080001 10593200 10594374 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01030049001 9176333 9186720 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01030049001 9176333 9186720 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01030049001 9176333 9186720 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030049001 9176333 9186720 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030049001 9176333 9186720 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01030049001 9176333 9186720 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01015681001 15520676 15521254 GSVIVG01035656001 3051066 3053938 GSVIVG01009135001 5378723 5441999 GSVIVG01014678001 8489461 8494866 GSVIVG01029303001 17240438 17290841 GSVIVG01020507001 18235216 18236248 GSVIVG01028841001 18165085 18179221 GSVIVG01001600001 18289693 18300956 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01001600001 18289693 18300956 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01001600001 18289693 18300956 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01001600001 18289693 18300956 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01001600001 18289693 18300956 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031575001 18370276 18379815 GSVIVG01033108001 25779088 25784003 GO:0006821 chloride transport The directed movement of chloride into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01033108001 25779088 25784003 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01033108001 25779088 25784003 GO:0006821 chloride transport The directed movement of chloride into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a chloride ion by a voltage-gated channel. IEA GO:0005247 voltage-gated chloride channel activity GSVIVG01033108001 25779088 25784003 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a chloride ion by a voltage-gated channel. IEA GO:0005247 voltage-gated chloride channel activity GSVIVG01026668001 4556095 4557489 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01026395001 15584857 15587835 GSVIVG01011854001 3548938 3552245 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01011854001 3548938 3552245 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01011854001 3548938 3552245 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01011854001 3548938 3552245 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003912001 13508805 13524669 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003912001 13508805 13524669 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01003912001 13508805 13524669 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01003912001 13508805 13524669 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0008236 serine-type peptidase activity GSVIVG01024846001 6499540 6500800 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA GSVIVG01018199001 13326032 13327597 GSVIVG01038176001 24083241 24086420 GSVIVG01011321001 8465618 8467690 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035045001 1135154 1141477 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01033447001 20633800 20634450 GSVIVG01037723001 7255562 7268617 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). IEA GO:0016772 transferase activity, transferring phosphorus-containing groups GSVIVG01010050001 13836492 13838405 GO:0046836 glycolipid transport The directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Enables the directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of, within or between cells. IEA GO:0017089 glycolipid transporter activity GSVIVG01010050001 13836492 13838405 GO:0046836 glycolipid transport The directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a glycolipid, any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic moiety such as an acylglycerol, a sphingoid, a ceramide (N-acylsphingoid) or a prenyl phosphate. IEA GO:0051861 glycolipid binding GSVIVG01035946001 6281237 6283155 GSVIVG01031711001 3656157 3664784 GSVIVG01035522001 1988516 2008180 GO:0007059 chromosome segregation The process by which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. IEA GO:0000775 chromosome, centromeric region The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035522001 1988516 2008180 GO:0007059 chromosome segregation The process by which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035522001 1988516 2008180 GO:0051301 cell division The process resulting in the physical partitioning and separation of a cell into daughter cells. IEA GO:0000775 chromosome, centromeric region The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035522001 1988516 2008180 GO:0051301 cell division The process resulting in the physical partitioning and separation of a cell into daughter cells. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01021099001 1448137 1454578 GSVIVG01033698001 18507500 18508987 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01032835001 364971 375613 GSVIVG01028885001 17818983 17824636 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01028885001 17818983 17824636 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01028885001 17818983 17824636 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01028885001 17818983 17824636 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01014343001 2820615 2830331 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01014343001 2820615 2830331 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01026024001 25724394 25724579 GSVIVG01013259001 6130868 6159014 GSVIVG01001980001 5996009 6010912 GO:0032313 regulation of Rab GTPase activity Any process that modulates the activity of a GTPase of the Rab family. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Increases the rate of GTP hydrolysis by a GTPase of the Rab family. IEA GO:0005097 Rab GTPase activator activity GSVIVG01034539001 19689525 19691184 GSVIVG01009533001 9115082 9117462 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA GSVIVG01009533001 9115082 9117462 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA GSVIVG01009533001 9115082 9117462 GO:0009405 pathogenesis The set of specific processes that generate the ability of an organism to cause disease in another. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA GSVIVG01029023001 10852780 10861431 GSVIVG01032907001 23982443 23984986 GSVIVG01024516001 9386644 9402123 GSVIVG01005852001 22247681 22248607 GSVIVG01034128001 14981483 14983124 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01013097001 8336138 8337118 GSVIVG01011601001 6068410 6076242 GSVIVG01028880001 17832829 17836814 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01028880001 17832829 17836814 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01028880001 17832829 17836814 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01028880001 17832829 17836814 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01028641001 11471748 11471912 GSVIVG01026149001 13041812 13049190 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GSVIVG01018866001 19116412 19130669 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01038652001 21183002 21188853 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01038652001 21183002 21188853 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01014359001 2979937 2982633 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01014359001 2979937 2982633 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01014359001 2979937 2982633 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01001185001 1026049 1028598 Functions in the storage of nutritious substrates. IEA GO:0045735 nutrient reservoir activity GSVIVG01014071001 101180 112143 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0008236 serine-type peptidase activity GSVIVG01016220001 6383670 6407474 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01016220001 6383670 6407474 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01016220001 6383670 6407474 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012931001 13764390 13764749 Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides. IEA GO:0004866 endopeptidase inhibitor activity GSVIVG01023733001 10251662 10252916 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009522 photosystem I A photosystem that contains an iron-sulfur reaction center associated with accessory pigments and electron carriers. In cyanobacteria and chloroplasts, photosystem I functions as a light-dependent plastocyanin-ferredoxin oxidoreductase, transferring electrons from plastocyanin to ferredoxin; in photosynthetic bacteria that have only a single type I photosystem, such as the green sulfur bacteria, electrons can go either to ferredoxin (Fd) -> NAD+ or to menaquinone (MK) -> Cytb/FeS -> Cytc555 -> photosystem I (cyclic photophosphorylation). IEA GSVIVG01023733001 10251662 10252916 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009579 thylakoid A membranous cellular structure that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the plasma membrane. In eukaryotes they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation. IEA GSVIVG01023733001 10251662 10252916 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01018684001 11163357 11164336 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01018684001 11163357 11164336 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01035256001 11504981 11507297 GO:0006821 chloride transport The directed movement of chloride into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. IEA GO:0004364 glutathione transferase activity GSVIVG01035256001 11504981 11507297 GO:0006821 chloride transport The directed movement of chloride into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a chloride ion by a voltage-gated channel. IEA GO:0005247 voltage-gated chloride channel activity GSVIVG01035256001 11504981 11507297 GO:0006821 chloride transport The directed movement of chloride into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01031913001 5324928 5346808 GSVIVG01015112001 1116644 1125084 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01032595001 28679521 28688251 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01031948001 5608889 5615417 GSVIVG01009892001 12179504 12193505 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01009252001 6661617 6681884 GSVIVG01038730001 8322 9914 GSVIVG01005212001 19249622 19257952 GSVIVG01035397001 998108 1000178 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01035397001 998108 1000178 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01035397001 998108 1000178 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01035397001 998108 1000178 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035397001 998108 1000178 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015066001 804979 806216 GSVIVG01026685001 4839218 4839757 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function that links a sequence-specific transcription factor to the core RNA polymerase II complex but does not bind DNA itself. IEA GO:0003712 transcription cofactor activity GSVIVG01026685001 4839218 4839757 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01037146001 28630141 28630427 GSVIVG01026144001 12928971 12933445 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0016272 prefoldin complex A multisubunit chaperone that acts to delivers unfolded proteins to cytosolic chaperonin. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01029112001 19555292 19558985 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029112001 19555292 19558985 GO:0009228 thiamin biosynthetic process The chemical reactions and pathways resulting in the formation of thiamin (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029112001 19555292 19558985 GO:0016114 terpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029112001 19555292 19558985 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. IEA GO:0008661 1-deoxy-D-xylulose-5-phosphate synthase activity GSVIVG01029112001 19555292 19558985 GO:0009228 thiamin biosynthetic process The chemical reactions and pathways resulting in the formation of thiamin (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver. IEA Catalysis of the reaction: pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. IEA GO:0008661 1-deoxy-D-xylulose-5-phosphate synthase activity GSVIVG01029112001 19555292 19558985 GO:0016114 terpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure. IEA Catalysis of the reaction: pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. IEA GO:0008661 1-deoxy-D-xylulose-5-phosphate synthase activity GSVIVG01029112001 19555292 19558985 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide. IEA GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor GSVIVG01029112001 19555292 19558985 GO:0009228 thiamin biosynthetic process The chemical reactions and pathways resulting in the formation of thiamin (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver. IEA Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide. IEA GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor GSVIVG01029112001 19555292 19558985 GO:0016114 terpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure. IEA Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide. IEA GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor GSVIVG01021452001 5532416 5533117 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA GSVIVG01029182001 18842755 18848126 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029286001 17539348 17546477 GSVIVG01020048001 11184010 11186116 GSVIVG01022393001 19596711 19612703 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01022393001 19596711 19612703 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01022393001 19596711 19612703 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01022393001 19596711 19612703 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01022393001 19596711 19612703 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010547001 16737596 16755347 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01016890001 2317151 2320017 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01016890001 2317151 2320017 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01016890001 2317151 2320017 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01025760001 12155281 12158011 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004185 serine-type carboxypeptidase activity GSVIVG01013827001 4915538 4917247 GO:0042545 cell wall modification The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the reaction: pectin + n H2O = n methanol + pectate. IEA GO:0030599 pectinesterase activity GSVIVG01020347001 20987714 21002630 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with transfer RNA. IEA GO:0000049 tRNA binding GSVIVG01020347001 20987714 21002630 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with transfer RNA. IEA GO:0000049 tRNA binding GSVIVG01020347001 20987714 21002630 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with transfer RNA. IEA GO:0000049 tRNA binding GSVIVG01020347001 20987714 21002630 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020347001 20987714 21002630 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020347001 20987714 21002630 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020347001 20987714 21002630 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01020347001 20987714 21002630 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01020347001 20987714 21002630 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01020347001 20987714 21002630 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe). IEA GO:0004826 phenylalanine-tRNA ligase activity GSVIVG01020347001 20987714 21002630 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe). IEA GO:0004826 phenylalanine-tRNA ligase activity GSVIVG01020347001 20987714 21002630 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe). IEA GO:0004826 phenylalanine-tRNA ligase activity GSVIVG01020347001 20987714 21002630 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020347001 20987714 21002630 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020347001 20987714 21002630 GO:0006432 phenylalanyl-tRNA aminoacylation The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016931001 2668983 2677069 GO:0019310 inositol catabolic process The chemical reactions and pathways resulting in the breakdown of inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01016931001 2668983 2677069 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01016931001 2668983 2677069 GO:0019310 inositol catabolic process The chemical reactions and pathways resulting in the breakdown of inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: myo-inositol + O2 = D-glucuronate + H2O. IEA GO:0050113 inositol oxygenase activity GSVIVG01016931001 2668983 2677069 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: myo-inositol + O2 = D-glucuronate + H2O. IEA GO:0050113 inositol oxygenase activity GSVIVG01019939001 4625182 4628502 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01036464001 22367887 22370399 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01036464001 22367887 22370399 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024054001 1472504 1476203 GSVIVG01026769001 6772804 6773440 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01038241001 24552749 24554976 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01038241001 24552749 24554976 GO:0007047 cellular cell wall organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01038241001 24552749 24554976 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01038241001 24552749 24554976 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01038241001 24552749 24554976 GO:0007047 cellular cell wall organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01038241001 24552749 24554976 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01038241001 24552749 24554976 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01038241001 24552749 24554976 GO:0007047 cellular cell wall organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01038241001 24552749 24554976 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01026844001 20016751 20023824 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01017737001 3023194 3024895 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01009261001 6775055 6788180 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01034113001 15074004 15077438 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01034113001 15074004 15077438 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01034113001 15074004 15077438 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025701001 12843442 12845830 GSVIVG01036443001 21977644 21981253 GSVIVG01033645001 18985319 18992118 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01033645001 18985319 18992118 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01033645001 18985319 18992118 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033645001 18985319 18992118 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033645001 18985319 18992118 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01033645001 18985319 18992118 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01033645001 18985319 18992118 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01033645001 18985319 18992118 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01033645001 18985319 18992118 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01033645001 18985319 18992118 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01000621001 13985238 13986407 GSVIVG01021259001 3096207 3103623 GO:0006817 phosphate transport The directed movement of phosphate into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a inorganic phosphate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport. IEA GO:0005315 inorganic phosphate transmembrane transporter activity GSVIVG01006217001 23737365 23740114 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01006217001 23737365 23740114 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009512 cytochrome b6f complex Complex that transfers electrons from reduced plastoquinone to oxidized plastocyanin and translocates protons from the stroma to the lumen. The complex contains a core structure of three catalytic subunits: cytochrome b, the Rieske iron sulfur protein (ISP), and cytochrome f, which are arranged in an integral membrane-bound dimeric complex; additional subunits are present, and vary among different species. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01006217001 23737365 23740114 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Enables the directed movement of electrons within the cytochrome b6/f complex of photosystem II. IEA GO:0045158 electron transporter, transferring electrons within cytochrome b6/f complex of photosystem II activity GSVIVG01006217001 23737365 23740114 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009512 cytochrome b6f complex Complex that transfers electrons from reduced plastoquinone to oxidized plastocyanin and translocates protons from the stroma to the lumen. The complex contains a core structure of three catalytic subunits: cytochrome b, the Rieske iron sulfur protein (ISP), and cytochrome f, which are arranged in an integral membrane-bound dimeric complex; additional subunits are present, and vary among different species. IEA Enables the directed movement of electrons within the cytochrome b6/f complex of photosystem II. IEA GO:0045158 electron transporter, transferring electrons within cytochrome b6/f complex of photosystem II activity GSVIVG01028739001 19246766 19251841 GSVIVG01033430001 20754083 20786254 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01033430001 20754083 20786254 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01033430001 20754083 20786254 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01033430001 20754083 20786254 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01033430001 20754083 20786254 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01033430001 20754083 20786254 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01033430001 20754083 20786254 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01033430001 20754083 20786254 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01030489001 6128660 6135333 GSVIVG01021260001 3105505 3113122 GO:0005992 trehalose biosynthetic process The chemical reactions and pathways resulting in the formation of trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021260001 3105505 3113122 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019693001 2512150 2516229 GSVIVG01026818001 20263835 20268788 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GSVIVG01003570001 14734003 14735889 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003570001 14734003 14735889 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031310001 479208 484304 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031310001 479208 484304 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008887001 3170427 3174977 GSVIVG01008079001 5988670 5999848 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin. IEA GO:0004221 ubiquitin thiolesterase activity GSVIVG01008079001 5988670 5999848 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01033351001 21285349 21289892 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01003827001 20474492 20475588 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: 3-alpha(S)-strictosidine = tryptamine + secologanin. IEA GO:0016844 strictosidine synthase activity GSVIVG01026021001 25769090 25781198 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01026021001 25769090 25781198 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01026021001 25769090 25781198 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01026021001 25769090 25781198 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026021001 25769090 25781198 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020067001 10846297 10848235 Catalysis of the eliminative cleavage of pectate to give oligosaccharides with 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their non-reducing ends. IEA GO:0030570 pectate lyase activity GSVIVG01033716001 18390358 18391452 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GSVIVG01038724001 20584549 20585231 GSVIVG01027552001 15696738 15702928 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01027552001 15696738 15702928 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01027552001 15696738 15702928 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01027552001 15696738 15702928 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01001178001 1048220 1052192 GO:0006869 lipid transport The directed movement of lipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Interacting selectively and non-covalently with a lipid. IEA GO:0008289 lipid binding GSVIVG01001178001 1048220 1052192 GO:0009405 pathogenesis The set of specific processes that generate the ability of an organism to cause disease in another. IEA Interacting selectively and non-covalently with a lipid. IEA GO:0008289 lipid binding GSVIVG01025712001 12741119 12758023 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025712001 12741119 12758023 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025712001 12741119 12758023 Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01025712001 12741119 12758023 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01001772001 2994505 3000152 GSVIVG01035647001 2958242 2971785 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: UDP-glucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein = UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein. IEA GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity GSVIVG01019941001 4638015 4641655 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01036537001 23153792 23160345 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01036537001 23153792 23160345 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ribosomal RNA. IEA GO:0019843 rRNA binding GSVIVG01033896001 16922740 16923372 GSVIVG01009951001 12767385 12770597 GSVIVG01038716001 20648811 20661453 GSVIVG01019597001 1834524 1837791 GSVIVG01022563001 5111431 5112204 GSVIVG01026581001 21416365 21416613 GSVIVG01009061001 4610529 4612093 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01008115001 5661947 5664086 GSVIVG01038606001 21537643 21539945 GSVIVG01012942001 14084361 14084525 GSVIVG01004255001 37740507 37740936 GSVIVG01023886001 2667488 2673608 GSVIVG01012087001 1558082 1561472 GSVIVG01015271001 2299080 2306321 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005945 6-phosphofructokinase complex A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known. IEA Catalysis of the reaction: ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate. IEA GO:0003872 6-phosphofructokinase activity GSVIVG01015271001 2299080 2306321 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005945 6-phosphofructokinase complex A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016602001 2485403 2488495 GSVIVG01017234001 5754560 5757863 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01017234001 5754560 5757863 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01017234001 5754560 5757863 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01017234001 5754560 5757863 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01017234001 5754560 5757863 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01017234001 5754560 5757863 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017234001 5754560 5757863 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017234001 5754560 5757863 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017234001 5754560 5757863 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017234001 5754560 5757863 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017234001 5754560 5757863 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01017234001 5754560 5757863 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01017234001 5754560 5757863 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01017234001 5754560 5757863 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01017234001 5754560 5757863 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01004319001 38071918 38078767 GSVIVG01027304001 16916122 16916510 GSVIVG01002073001 32706456 32707571 GSVIVG01034485001 20598144 20599942 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01037112001 29047000 29058675 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01037112001 29047000 29058675 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01037112001 29047000 29058675 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01037112001 29047000 29058675 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01037112001 29047000 29058675 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010481001 20944606 20952346 GSVIVG01023785001 3482512 3484808 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA GSVIVG01028271001 5061491 5156680 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01028271001 5061491 5156680 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01015531001 4603020 4606784 GSVIVG01025645001 13353932 13355074 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01033407001 20923569 20931059 Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0010181 FMN binding GSVIVG01029002001 10533652 10534725 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. IEA GO:0004364 glutathione transferase activity GSVIVG01021915001 5677377 5678243 GSVIVG01036792001 22500178 22502622 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01036792001 22500178 22502622 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01010302001 19219004 19219813 GSVIVG01008583001 723570 725613 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. IEA GO:0016597 amino acid binding GSVIVG01014698001 8744183 8752009 GO:0006464 protein modification process The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. IEA GO:0016881 acid-amino acid ligase activity GSVIVG01014698001 8744183 8752009 GO:0019941 modification-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. IEA GO:0016881 acid-amino acid ligase activity GSVIVG01007204001 30803736 30805695 GSVIVG01036587001 18700579 18707872 GSVIVG01029677001 12902784 12903273 GSVIVG01011431001 29607798 29608028 GO:0009507 chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024107001 1006320 1007936 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024107001 1006320 1007936 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024107001 1006320 1007936 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024107001 1006320 1007936 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01024107001 1006320 1007936 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01024107001 1006320 1007936 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01024107001 1006320 1007936 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01024107001 1006320 1007936 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01024107001 1006320 1007936 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01009684001 10435436 10445386 GSVIVG01021582001 7410409 7412864 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01021582001 7410409 7412864 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01021582001 7410409 7412864 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01021582001 7410409 7412864 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008520001 1138002 1138926 GSVIVG01007899001 7764658 7767737 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01036877001 18342284 18345229 GSVIVG01033426001 20818554 20820683 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01006523001 42851595 42851940 GSVIVG01014677001 8484222 8488496 GSVIVG01034702001 8002454 8003038 GSVIVG01015210001 1850811 1855800 GSVIVG01011585001 6241008 6248273 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01000104001 15305304 15306420 GSVIVG01024980001 5548568 5552191 GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01024980001 5548568 5552191 GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01024980001 5548568 5552191 GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01024980001 5548568 5552191 GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01024980001 5548568 5552191 GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01024980001 5548568 5552191 GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034628001 13699734 13703514 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01034628001 13699734 13703514 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01034628001 13699734 13703514 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01034628001 13699734 13703514 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01000821001 606423 614401 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01000821001 606423 614401 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01000821001 606423 614401 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000821001 606423 614401 Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01000821001 606423 614401 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01015386001 3187392 3190945 GSVIVG01037769001 7709734 7714248 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01037128001 28851987 28852224 GSVIVG01031928001 5462190 5464132 GSVIVG01023908001 2533266 2533712 GSVIVG01034631001 13686336 13687861 GSVIVG01018767001 20090880 20092677 GSVIVG01002584001 35315559 35319027 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01002584001 35315559 35319027 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01002584001 35315559 35319027 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01002584001 35315559 35319027 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01002584001 35315559 35319027 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01002584001 35315559 35319027 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01002584001 35315559 35319027 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01002584001 35315559 35319027 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01002584001 35315559 35319027 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01002584001 35315559 35319027 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01028576001 10087657 10098029 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01026941001 19210662 19214316 GSVIVG01019648001 2196016 2200712 GO:0032313 regulation of Rab GTPase activity Any process that modulates the activity of a GTPase of the Rab family. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Increases the rate of GTP hydrolysis by a GTPase of the Rab family. IEA GO:0005097 Rab GTPase activator activity GSVIVG01010695001 11919414 11934842 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010695001 11919414 11934842 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010695001 11919414 11934842 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01010695001 11919414 11934842 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01010695001 11919414 11934842 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01010695001 11919414 11934842 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01032765001 936047 937943 The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01011422001 29542310 29545724 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01011422001 29542310 29545724 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01011422001 29542310 29545724 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01011422001 29542310 29545724 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01011422001 29542310 29545724 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01011422001 29542310 29545724 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01011422001 29542310 29545724 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01011422001 29542310 29545724 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01011422001 29542310 29545724 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01011422001 29542310 29545724 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids. IEA GO:0030060 L-malate dehydrogenase activity GSVIVG01011422001 29542310 29545724 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids. IEA GO:0030060 L-malate dehydrogenase activity GSVIVG01011422001 29542310 29545724 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids. IEA GO:0030060 L-malate dehydrogenase activity GSVIVG01024946001 5817226 5819618 GO:0009306 protein secretion The controlled release of proteins from a cell or group of cells. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01024946001 5817226 5819618 GO:0009306 protein secretion The controlled release of proteins from a cell or group of cells. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01024946001 5817226 5819618 GO:0009664 plant-type cell wall organization A process that results in the assembly and arrangement of constituent parts of the cellulose and pectin-containing cell wall, or in the disassembly of the cellulose and pectin-containing cell wall. This process is carried out at the cellular level. An example of this process is found in Arabidopsis thaliana. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01024946001 5817226 5819618 GO:0009664 plant-type cell wall organization A process that results in the assembly and arrangement of constituent parts of the cellulose and pectin-containing cell wall, or in the disassembly of the cellulose and pectin-containing cell wall. This process is carried out at the cellular level. An example of this process is found in Arabidopsis thaliana. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01017455001 8736212 8737476 GO:0006171 cAMP biosynthetic process The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). IEA Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate. IEA GO:0004016 adenylate cyclase activity GSVIVG01021307001 3786195 3793211 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01014217001 1570519 1570851 GSVIVG01018659001 11544451 11558689 GSVIVG01006142001 42066105 42067075 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01006142001 42066105 42067075 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01006142001 42066105 42067075 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035304001 212415 239173 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01035304001 212415 239173 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01035304001 212415 239173 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01035304001 212415 239173 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035304001 212415 239173 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025206001 3312466 3315895 GSVIVG01029431001 22992440 23001862 GSVIVG01023357001 19382783 19383572 GSVIVG01010747001 22089860 22095722 GO:0018346 protein amino acid prenylation The covalent attachment of a prenyl moiety to a protein amino acid. IEA Catalysis of the covalent addition of an isoprenoid group such as a farnesyl or geranylgeranyl group via thioether linkages to a cysteine residue in a protein. IEA GO:0008318 protein prenyltransferase activity GSVIVG01003153001 6179765 6181426 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003153001 6179765 6181426 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003153001 6179765 6181426 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01003153001 6179765 6181426 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01003153001 6179765 6181426 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01003153001 6179765 6181426 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01003153001 6179765 6181426 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01003153001 6179765 6181426 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01027142001 17474780 17487538 GSVIVG01002015001 32285710 32286435 GSVIVG01020141001 9902416 9904513 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01024904001 6141887 6144982 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011805001 4011125 4016189 GSVIVG01018586001 12778035 12779908 Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01018586001 12778035 12779908 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018586001 12778035 12779908 Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01018586001 12778035 12779908 Interacting selectively and non-covalently with thiamin pyrophosphate, the diphosphoric ester of thiamin. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases. IEA GO:0030976 thiamin pyrophosphate binding GSVIVG01033906001 16832621 16837876 GSVIVG01003736001 7519212 7525837 GSVIVG01030499001 6232879 6243395 GSVIVG01002344001 34245717 34245938 GSVIVG01007623001 11137854 11141274 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01015032001 587528 595578 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015032001 587528 595578 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015032001 587528 595578 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015032001 587528 595578 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01015032001 587528 595578 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01015032001 587528 595578 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01029475001 22433612 22440313 GSVIVG01029470001 22465752 22467718 GSVIVG01034390001 16923219 16923729 GSVIVG01006136001 42033520 42034556 GSVIVG01019492001 1066670 1090707 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01019492001 1066670 1090707 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01019492001 1066670 1090707 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010528001 21491275 21495686 GSVIVG01028347001 6410007 6416352 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01028347001 6410007 6416352 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032659001 1742738 1746172 GSVIVG01027443001 16686270 16691805 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01027443001 16686270 16691805 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01009405001 8050120 8054991 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01009405001 8050120 8054991 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01009405001 8050120 8054991 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01009405001 8050120 8054991 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01022302001 18351180 18353111 GSVIVG01017244001 5862839 5867495 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01017244001 5862839 5867495 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds. IEA GO:0015035 protein disulfide oxidoreductase activity GSVIVG01028709001 19553502 19561941 GSVIVG01010749001 22104774 22131603 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with double-stranded RNA. IEA GO:0003725 double-stranded RNA binding GSVIVG01025303001 2282771 2283533 GO:0017003 protein-heme linkage The covalent linkage of heme and a protein. IEA GO:0005886 plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. IEA GSVIVG01025303001 2282771 2283533 GO:0017004 cytochrome complex assembly The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. IEA GO:0005886 plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. IEA GSVIVG01031600001 18760946 18763626 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01000771001 686589 688584 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01020292001 21811437 21812969 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020292001 21811437 21812969 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020292001 21811437 21812969 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020292001 21811437 21812969 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020292001 21811437 21812969 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020292001 21811437 21812969 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020292001 21811437 21812969 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01020292001 21811437 21812969 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01008903001 3269851 3281510 GSVIVG01001427001 19026978 19032485 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001427001 19026978 19032485 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001427001 19026978 19032485 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001427001 19026978 19032485 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001427001 19026978 19032485 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01001427001 19026978 19032485 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01001427001 19026978 19032485 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01001427001 19026978 19032485 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01001427001 19026978 19032485 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01001427001 19026978 19032485 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01001427001 19026978 19032485 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01001427001 19026978 19032485 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01001427001 19026978 19032485 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001427001 19026978 19032485 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001427001 19026978 19032485 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001427001 19026978 19032485 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001427001 19026978 19032485 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01001427001 19026978 19032485 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01001427001 19026978 19032485 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01001427001 19026978 19032485 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01023320001 19766685 19771021 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023320001 19766685 19771021 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01004916001 4768239 4782009 GSVIVG01023531001 10167815 10169394 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01032467001 27707133 27709288 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01000939001 22080242 22083611 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01020185001 9309085 9312774 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01034224001 13012090 13014631 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01034224001 13012090 13014631 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01034224001 13012090 13014631 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01034224001 13012090 13014631 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01015212001 1862458 1869783 GSVIVG01004711001 15420637 15422511 GSVIVG01021468001 5846741 5848388 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01021468001 5846741 5848388 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008340001 3110882 3118753 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008340001 3110882 3118753 GO:0006013 mannose metabolic process The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008340001 3110882 3118753 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01008340001 3110882 3118753 GO:0006013 mannose metabolic process The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01008340001 3110882 3118753 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. IEA GO:0004559 alpha-mannosidase activity GSVIVG01008340001 3110882 3118753 GO:0006013 mannose metabolic process The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins. IEA Catalysis of the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. IEA GO:0004559 alpha-mannosidase activity GSVIVG01008340001 3110882 3118753 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008340001 3110882 3118753 GO:0006013 mannose metabolic process The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008340001 3110882 3118753 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of mannosyl compounds, substances containing a group derived from a cyclic form of mannose or a mannose derivative. IEA GO:0015923 mannosidase activity GSVIVG01008340001 3110882 3118753 GO:0006013 mannose metabolic process The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins. IEA Catalysis of the hydrolysis of mannosyl compounds, substances containing a group derived from a cyclic form of mannose or a mannose derivative. IEA GO:0015923 mannosidase activity GSVIVG01008340001 3110882 3118753 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01008340001 3110882 3118753 GO:0006013 mannose metabolic process The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins. IEA Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01017661001 2435658 2438610 GSVIVG01019511001 1228314 1229702 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01019511001 1228314 1229702 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01034647001 13445899 13451653 GSVIVG01002752001 36381141 36382183 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01002752001 36381141 36382183 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01002752001 36381141 36382183 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015935 small ribosomal subunit The smaller of the two subunits of a ribosome. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01002752001 36381141 36382183 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01002752001 36381141 36382183 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01002752001 36381141 36382183 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0015935 small ribosomal subunit The smaller of the two subunits of a ribosome. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01002752001 36381141 36382183 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. IEA GO:0008137 NADH dehydrogenase (ubiquinone) activity GSVIVG01002752001 36381141 36382183 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. IEA GO:0008137 NADH dehydrogenase (ubiquinone) activity GSVIVG01002752001 36381141 36382183 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0015935 small ribosomal subunit The smaller of the two subunits of a ribosome. IEA Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. IEA GO:0008137 NADH dehydrogenase (ubiquinone) activity GSVIVG01002752001 36381141 36382183 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. IEA GO:0008137 NADH dehydrogenase (ubiquinone) activity GSVIVG01002752001 36381141 36382183 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. IEA GO:0008137 NADH dehydrogenase (ubiquinone) activity GSVIVG01002752001 36381141 36382183 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0015935 small ribosomal subunit The smaller of the two subunits of a ribosome. IEA Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. IEA GO:0008137 NADH dehydrogenase (ubiquinone) activity GSVIVG01020865001 830388 845850 GSVIVG01013171001 7184234 7189385 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01021071001 14146034 14151956 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01037839001 7303288 7311164 GSVIVG01006159001 42255471 42257727 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01006159001 42255471 42257727 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01006159001 42255471 42257727 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01006159001 42255471 42257727 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013752001 7941994 7942663 GSVIVG01025046001 5032922 5035340 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01025046001 5032922 5035340 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01025046001 5032922 5035340 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01025046001 5032922 5035340 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01025046001 5032922 5035340 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025046001 5032922 5035340 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01011603001 6044217 6047143 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01011603001 6044217 6047143 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01011603001 6044217 6047143 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01011603001 6044217 6047143 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01011603001 6044217 6047143 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01011603001 6044217 6047143 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01011603001 6044217 6047143 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01011603001 6044217 6047143 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01016311001 5245072 5248943 GO:0006367 transcription initiation from RNA polymerase II promoter A transcription initiation process that results in RNA synthesis by RNA polymerase II. IEA GO:0005674 transcription factor TFIIF complex A general transcription initiation factor which in humans consists of a heterodimer of an alpha and a beta subunit. Helps recruit RNA polymerase II to the initiation complex and promotes translation elongation. IEA Functions to initiate or regulate RNA polymerase II transcription. IEA GO:0003702 RNA polymerase II transcription factor activity GSVIVG01016311001 5245072 5248943 GO:0006367 transcription initiation from RNA polymerase II promoter A transcription initiation process that results in RNA synthesis by RNA polymerase II. IEA GO:0005674 transcription factor TFIIF complex A general transcription initiation factor which in humans consists of a heterodimer of an alpha and a beta subunit. Helps recruit RNA polymerase II to the initiation complex and promotes translation elongation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016311001 5245072 5248943 GO:0006367 transcription initiation from RNA polymerase II promoter A transcription initiation process that results in RNA synthesis by RNA polymerase II. IEA GO:0005674 transcription factor TFIIF complex A general transcription initiation factor which in humans consists of a heterodimer of an alpha and a beta subunit. Helps recruit RNA polymerase II to the initiation complex and promotes translation elongation. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035585001 2520411 2529950 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01035585001 2520411 2529950 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01029721001 13761211 13761496 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01029721001 13761211 13761496 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01033823001 17443201 17451131 Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum. IEA GO:0003993 acid phosphatase activity GSVIVG01033823001 17443201 17451131 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01033823001 17443201 17451131 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01033727001 18300064 18301983 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01033727001 18300064 18301983 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01033727001 18300064 18301983 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01033727001 18300064 18301983 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036188001 9306148 9316608 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01036188001 9306148 9316608 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01036188001 9306148 9316608 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036188001 9306148 9316608 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036188001 9306148 9316608 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036188001 9306148 9316608 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036188001 9306148 9316608 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01036188001 9306148 9316608 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01029281001 17655373 17658529 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01029281001 17655373 17658529 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01029281001 17655373 17658529 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01029281001 17655373 17658529 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029281001 17655373 17658529 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022568001 5172881 5174662 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01022568001 5172881 5174662 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds. IEA GO:0015035 protein disulfide oxidoreductase activity GSVIVG01035500001 1818745 1822320 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin. IEA GO:0004221 ubiquitin thiolesterase activity GSVIVG01035500001 1818745 1822320 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with the beta subunit of the catenin complex. IEA GO:0008013 beta-catenin binding GSVIVG01015071001 833857 849309 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01015071001 833857 849309 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01015071001 833857 849309 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01015071001 833857 849309 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01031700001 3554244 3555820 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. IEA GO:0005179 hormone activity GSVIVG01031700001 3554244 3555820 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. IEA GO:0005179 hormone activity GSVIVG01031700001 3554244 3555820 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. IEA GO:0005179 hormone activity GSVIVG01031700001 3554244 3555820 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. IEA GO:0005179 hormone activity GSVIVG01031700001 3554244 3555820 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. IEA GO:0005179 hormone activity GSVIVG01031700001 3554244 3555820 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. IEA GO:0005179 hormone activity GSVIVG01031700001 3554244 3555820 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01031700001 3554244 3555820 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01031700001 3554244 3555820 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01031700001 3554244 3555820 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01031700001 3554244 3555820 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01031700001 3554244 3555820 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01031700001 3554244 3555820 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA The action of a molecule that contributes to the structural integrity of a cell wall. IEA GO:0005199 structural constituent of cell wall GSVIVG01031700001 3554244 3555820 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA The action of a molecule that contributes to the structural integrity of a cell wall. IEA GO:0005199 structural constituent of cell wall GSVIVG01031700001 3554244 3555820 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The action of a molecule that contributes to the structural integrity of a cell wall. IEA GO:0005199 structural constituent of cell wall GSVIVG01031700001 3554244 3555820 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA The action of a molecule that contributes to the structural integrity of a cell wall. IEA GO:0005199 structural constituent of cell wall GSVIVG01031700001 3554244 3555820 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA The action of a molecule that contributes to the structural integrity of a cell wall. IEA GO:0005199 structural constituent of cell wall GSVIVG01031700001 3554244 3555820 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The action of a molecule that contributes to the structural integrity of a cell wall. IEA GO:0005199 structural constituent of cell wall GSVIVG01028984001 16907193 16908873 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01036352001 4108736 4109383 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01032940001 24473557 24478055 GSVIVG01007347001 31467857 31471860 GSVIVG01021992001 4637641 4647999 GSVIVG01001175001 1061769 1066983 GSVIVG01000679001 15309713 15310119 GSVIVG01019584001 1746546 1777292 GSVIVG01016892001 2339917 2348008 GSVIVG01031954001 5671230 5673586 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01031954001 5671230 5673586 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01031954001 5671230 5673586 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01031954001 5671230 5673586 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011907001 3084064 3093046 GO:0006289 nucleotide-excision repair A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with damaged DNA. IEA GO:0003684 damaged DNA binding GSVIVG01011907001 3084064 3093046 GO:0043161 proteasomal ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with damaged DNA. IEA GO:0003684 damaged DNA binding GSVIVG01029815001 15207121 15209056 GSVIVG01028802001 18632562 18634313 GSVIVG01000920001 21915490 21919833 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026675001 4619393 4620618 GSVIVG01005491001 40449906 40450705 GSVIVG01021266001 3210801 3212829 GSVIVG01012386001 311022 311844 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012386001 311022 311844 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01022975001 17378315 17385866 GSVIVG01011284001 10567620 10591814 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: bile acid(out) + Na+(out) = bile acid(in) + Na+(in). IEA GO:0008508 bile acid:sodium symporter activity GSVIVG01006469001 26248172 26248995 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01003118001 7416007 7419722 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01003118001 7416007 7419722 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01028493001 8392552 8411643 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01030945001 19574270 19589949 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01030945001 19574270 19589949 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01024569001 8785300 8791033 GO:0009186 deoxyribonucleoside diphosphate metabolic process The chemical reactions and pathways involving a deoxyribonucleoside diphosphate, a glycosamine consisting of a base linked to a deoxyribose sugar esterified with diphosphate on its glycose moiety. IEA Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin. IEA GO:0004748 ribonucleoside-diphosphate reductase activity GSVIVG01024569001 8785300 8791033 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin. IEA GO:0004748 ribonucleoside-diphosphate reductase activity GSVIVG01024569001 8785300 8791033 GO:0009186 deoxyribonucleoside diphosphate metabolic process The chemical reactions and pathways involving a deoxyribonucleoside diphosphate, a glycosamine consisting of a base linked to a deoxyribose sugar esterified with diphosphate on its glycose moiety. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024569001 8785300 8791033 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024569001 8785300 8791033 GO:0009186 deoxyribonucleoside diphosphate metabolic process The chemical reactions and pathways involving a deoxyribonucleoside diphosphate, a glycosamine consisting of a base linked to a deoxyribose sugar esterified with diphosphate on its glycose moiety. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01024569001 8785300 8791033 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. IEA GO:0046914 transition metal ion binding GSVIVG01037785001 7850485 7850859 GSVIVG01023383001 19143306 19143599 GO:0006306 DNA methylation The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01036048001 21415996 21422132 GSVIVG01000162001 15762668 15764039 GSVIVG01016480001 3509388 3514001 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01016480001 3509388 3514001 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01030009001 8909738 8910595 GSVIVG01002823001 36809254 36811486 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01001235001 1720910 1721149 GSVIVG01015288001 2421903 2430636 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01018473001 14576735 14592040 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01018473001 14576735 14592040 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01018473001 14576735 14592040 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01018473001 14576735 14592040 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01001763001 6224501 6224620 GSVIVG01021967001 4994511 4995285 GSVIVG01033262001 22052245 22054074 GSVIVG01016100001 18973023 18975323 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01016056001 18112568 18113665 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016056001 18112568 18113665 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01016056001 18112568 18113665 Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. IEA GO:0016881 acid-amino acid ligase activity GSVIVG01016056001 18112568 18113665 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01022127001 16790184 16794481 GSVIVG01038129001 23697143 23700589 GSVIVG01034119001 15031499 15033468 GSVIVG01016994001 3252781 3253351 GSVIVG01020984001 15932661 15935511 GSVIVG01019737001 2851920 2853149 GSVIVG01021232001 2805503 2807184 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01021232001 2805503 2807184 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01021232001 2805503 2807184 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01021232001 2805503 2807184 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01021232001 2805503 2807184 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021232001 2805503 2807184 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020341001 21068254 21068614 GSVIVG01031772001 4261888 4262850 GSVIVG01000042001 3003895 3011495 GSVIVG01025021001 5194694 5195564 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025021001 5194694 5195564 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01005054001 17736838 17740900 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01005054001 17736838 17740900 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021930001 5494527 5495046 GSVIVG01025019001 5226169 5227478 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025019001 5226169 5227478 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025019001 5226169 5227478 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01000603001 6622467 6624298 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000603001 6622467 6624298 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000603001 6622467 6624298 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000603001 6622467 6624298 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01000603001 6622467 6624298 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01000603001 6622467 6624298 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01000603001 6622467 6624298 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01000603001 6622467 6624298 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01000603001 6622467 6624298 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01000603001 6622467 6624298 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01000603001 6622467 6624298 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01000603001 6622467 6624298 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01035598001 2604513 2611059 GSVIVG01030580001 6871830 6884865 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01030580001 6871830 6884865 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01030580001 6871830 6884865 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01030580001 6871830 6884865 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01029689001 13100137 13108621 GSVIVG01034353001 17618826 17627702 GSVIVG01028816001 18461596 18462737 GSVIVG01026787001 7158421 7168095 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01026787001 7158421 7168095 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01034991001 745680 748011 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01034991001 745680 748011 Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. IEA GO:0051536 iron-sulfur cluster binding GSVIVG01032454001 27583420 27584353 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01032454001 27583420 27584353 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01000965001 22323505 22323657 GSVIVG01016424001 4069338 4078809 GSVIVG01011502001 30074065 30077655 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01009527001 9065385 9069817 GSVIVG01012389001 326868 347866 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012389001 326868 347866 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012389001 326868 347866 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01012389001 326868 347866 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01012389001 326868 347866 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01012389001 326868 347866 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01024805001 6809015 6813604 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01024805001 6809015 6813604 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01038166001 24028616 24028807 GSVIVG01029388001 15994779 15999389 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: UDP-glucose + D-fructose = UDP + sucrose. IEA GO:0016157 sucrose synthase activity GSVIVG01027810001 8035771 8037251 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01003741001 7552161 7553065 GSVIVG01006972001 29489812 29494812 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01006972001 29489812 29494812 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01006972001 29489812 29494812 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01006972001 29489812 29494812 GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. IEA Interacting selectively and non-covalently with an identical protein or proteins. IEA GO:0042802 identical protein binding GSVIVG01031351001 130240 131556 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with manganese (Mn) ions. IEA GO:0030145 manganese ion binding GSVIVG01031351001 130240 131556 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Functions in the storage of nutritious substrates. IEA GO:0045735 nutrient reservoir activity GSVIVG01031351001 130240 131556 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01034044001 15615702 15620790 GSVIVG01022453001 3207937 3210034 GSVIVG01025731001 12522958 12528063 GSVIVG01000084001 3315947 3324623 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01000084001 3315947 3324623 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: linoleate + O2 = (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate. IEA GO:0016165 lipoxygenase activity GSVIVG01000084001 3315947 3324623 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01000084001 3315947 3324623 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor. IEA GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen GSVIVG01000084001 3315947 3324623 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01019557001 1595085 1600755 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01019557001 1595085 1600755 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01019557001 1595085 1600755 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01019557001 1595085 1600755 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01019557001 1595085 1600755 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01019557001 1595085 1600755 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01019557001 1595085 1600755 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01019557001 1595085 1600755 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01019557001 1595085 1600755 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01019557001 1595085 1600755 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01019557001 1595085 1600755 GO:0007275 multicellular organismal development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01019557001 1595085 1600755 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01037978001 11979461 11979810 GSVIVG01037176001 28305575 28309440 GO:0006006 glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. IEA Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+. IEA GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity GSVIVG01037176001 28305575 28309440 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+. IEA GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity GSVIVG01037176001 28305575 28309440 GO:0006006 glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01037176001 28305575 28309440 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01000060001 3159742 3167009 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000060001 3159742 3167009 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with manganese (Mn) ions. IEA GO:0030145 manganese ion binding GSVIVG01000060001 3159742 3167009 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Functions in the storage of nutritious substrates. IEA GO:0045735 nutrient reservoir activity GSVIVG01000060001 3159742 3167009 GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01037925001 10983158 10984564 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01034467001 20855587 20865341 GSVIVG01009792001 11293544 11294740 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA GSVIVG01015411001 3379292 3380596 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01015411001 3379292 3380596 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01015411001 3379292 3380596 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01015411001 3379292 3380596 GO:0051260 protein homooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01015411001 3379292 3380596 GO:0051260 protein homooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01015411001 3379292 3380596 GO:0051260 protein homooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01015411001 3379292 3380596 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01015411001 3379292 3380596 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01015411001 3379292 3380596 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01015411001 3379292 3380596 GO:0051260 protein homooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01015411001 3379292 3380596 GO:0051260 protein homooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01015411001 3379292 3380596 GO:0051260 protein homooligomerization The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01037028001 8765958 8766906 GO:0006808 regulation of nitrogen utilization Any process that modulates the frequency, rate or extent of nitrogen utilization. IEA Modulates the activity of an enzyme. IEA GO:0030234 enzyme regulator activity GSVIVG01022337001 18588195 18618172 GSVIVG01035657001 3054749 3076022 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA GSVIVG01021834001 6711667 6720938 GSVIVG01028207001 4622319 4627018 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01017738001 3031098 3046782 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0031461 cullin-RING ubiquitin ligase complex Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity. IEA Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins. IEA GO:0031625 ubiquitin protein ligase binding GSVIVG01038154001 23922807 23927263 GSVIVG01035514001 1913811 1923695 GO:0006887 exocytosis A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell. This is the process whereby most molecules are secreted from eukaryotic cells. IEA GO:0000145 exocyst A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals. IEA GSVIVG01005141001 18507436 18511498 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01025824001 11471282 11478752 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01032586001 28585492 28592518 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032586001 28585492 28592518 GO:0006013 mannose metabolic process The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01032586001 28585492 28592518 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01032586001 28585492 28592518 GO:0006013 mannose metabolic process The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01032586001 28585492 28592518 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. IEA GO:0004559 alpha-mannosidase activity GSVIVG01032586001 28585492 28592518 GO:0006013 mannose metabolic process The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins. IEA Catalysis of the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. IEA GO:0004559 alpha-mannosidase activity GSVIVG01032586001 28585492 28592518 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01032586001 28585492 28592518 GO:0006013 mannose metabolic process The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01032586001 28585492 28592518 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of mannosyl compounds, substances containing a group derived from a cyclic form of mannose or a mannose derivative. IEA GO:0015923 mannosidase activity GSVIVG01032586001 28585492 28592518 GO:0006013 mannose metabolic process The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins. IEA Catalysis of the hydrolysis of mannosyl compounds, substances containing a group derived from a cyclic form of mannose or a mannose derivative. IEA GO:0015923 mannosidase activity GSVIVG01032586001 28585492 28592518 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01032586001 28585492 28592518 GO:0006013 mannose metabolic process The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins. IEA Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01011493001 30031078 30036233 GSVIVG01019473001 916178 932015 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01019473001 916178 932015 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01019473001 916178 932015 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019473001 916178 932015 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019473001 916178 932015 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01019473001 916178 932015 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01019473001 916178 932015 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01019473001 916178 932015 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01019473001 916178 932015 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01019473001 916178 932015 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01007541001 12455524 12456465 Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate. IEA GO:0008146 sulfotransferase activity GSVIVG01015593001 5309195 5325863 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01015593001 5309195 5325863 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01015593001 5309195 5325863 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01015593001 5309195 5325863 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01015593001 5309195 5325863 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01015593001 5309195 5325863 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01015593001 5309195 5325863 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01015593001 5309195 5325863 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01015593001 5309195 5325863 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01015593001 5309195 5325863 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01015593001 5309195 5325863 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01015593001 5309195 5325863 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01015593001 5309195 5325863 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01015593001 5309195 5325863 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01015593001 5309195 5325863 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01015593001 5309195 5325863 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01015989001 16832543 16839631 GSVIVG01024189001 484539 485522 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01007226001 30952324 30961914 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01037656001 6593738 6601198 GSVIVG01027229001 17855703 17858232 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01027229001 17855703 17858232 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01027229001 17855703 17858232 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027229001 17855703 17858232 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018809001 19681003 19683689 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01003526001 15753 19623 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01003526001 15753 19623 Catalysis of the reaction: ATP + shikimate = ADP + shikimate 3-phosphate. IEA GO:0004765 shikimate kinase activity GSVIVG01003526001 15753 19623 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003526001 15753 19623 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01000030001 2922506 2927819 GSVIVG01022297001 18313461 18318429 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01022297001 18313461 18318429 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01022297001 18313461 18318429 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01022297001 18313461 18318429 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01022297001 18313461 18318429 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01022297001 18313461 18318429 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors. IEA GO:0004965 GABA-B receptor activity GSVIVG01022297001 18313461 18318429 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01022297001 18313461 18318429 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01022297001 18313461 18318429 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01022297001 18313461 18318429 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01022297001 18313461 18318429 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01022297001 18313461 18318429 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. IEA GO:0004970 ionotropic glutamate receptor activity GSVIVG01022297001 18313461 18318429 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01022297001 18313461 18318429 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01022297001 18313461 18318429 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01022297001 18313461 18318429 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01022297001 18313461 18318429 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01022297001 18313461 18318429 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01022297001 18313461 18318429 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01022297001 18313461 18318429 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01022297001 18313461 18318429 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01022297001 18313461 18318429 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01022297001 18313461 18318429 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01022297001 18313461 18318429 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts. IEA GO:0005234 extracellular-glutamate-gated ion channel activity GSVIVG01026025001 25669728 25672223 GSVIVG01020571001 4186104 4209776 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020571001 4186104 4209776 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01028404001 7226266 7228871 Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum. IEA GO:0003993 acid phosphatase activity GSVIVG01038101001 23498292 23501139 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GSVIVG01026540001 22096878 22101390 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0000159 protein phosphatase type 2A complex A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit. IEA Modulation of the activity of the enzyme protein phosphatase type 2A. IEA GO:0008601 protein phosphatase type 2A regulator activity GSVIVG01031385001 19286590 19296263 GSVIVG01020605001 3840176 3862721 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01020605001 3840176 3862721 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01020605001 3840176 3862721 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01020605001 3840176 3862721 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01020605001 3840176 3862721 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01020605001 3840176 3862721 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01009390001 7956027 7958282 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01009390001 7956027 7958282 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01009390001 7956027 7958282 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01009390001 7956027 7958282 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01015733001 16584416 16599132 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GSVIVG01008449001 1903892 1909337 GO:0007034 vacuolar transport The directed movement of substances into, out of or within a vacuole. IEA GO:0030904 retromer complex A conserved multimeric membrane-associated complex involved in retrograde transport from endosomes to the Golgi apparatus. For example, the budding yeast retromer comprises Vps35p, Vps29p, Vps26p, Vps5p, and Vps17p. IEA GSVIVG01024500001 3383705 3385746 GSVIVG01020673001 3197727 3199670 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01034944001 339328 343662 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01034944001 339328 343662 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: a fructofuranosylated fructofuranosyl acceptor + H2O = a non fructofuranosylated fructofuranosyl acceptor + a beta-D-fructofuranoside. IEA GO:0004564 beta-fructofuranosidase activity GSVIVG01034944001 339328 343662 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01034944001 339328 343662 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01022520001 4282684 4284243 GSVIVG01009658001 10250572 10252002 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01024157001 702193 704571 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O. IEA GO:0004044 amidophosphoribosyltransferase activity GSVIVG01024157001 702193 704571 GO:0009113 purine base biosynthetic process The chemical reactions and pathways resulting in the formation of purine bases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine. IEA Catalysis of the reaction: 5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O. IEA GO:0004044 amidophosphoribosyltransferase activity GSVIVG01018449001 14959125 14964650 GO:0006014 D-ribose metabolic process The chemical reactions and pathways involving D-ribose (ribo-pentose). As beta-D-ribofuranose, D-ribose forms the glycose moiety of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12. IEA Catalysis of the reaction: ATP + adenosine = ADP + AMP. IEA GO:0004001 adenosine kinase activity GSVIVG01018449001 14959125 14964650 GO:0006166 purine ribonucleoside salvage Any process which produces a purine nucleoside from derivatives of it, without de novo synthesis. IEA Catalysis of the reaction: ATP + adenosine = ADP + AMP. IEA GO:0004001 adenosine kinase activity GSVIVG01018449001 14959125 14964650 GO:0006014 D-ribose metabolic process The chemical reactions and pathways involving D-ribose (ribo-pentose). As beta-D-ribofuranose, D-ribose forms the glycose moiety of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12. IEA Catalysis of the reaction: ATP + D-ribose = ADP + D-ribose 5-phosphate. IEA GO:0004747 ribokinase activity GSVIVG01018449001 14959125 14964650 GO:0006166 purine ribonucleoside salvage Any process which produces a purine nucleoside from derivatives of it, without de novo synthesis. IEA Catalysis of the reaction: ATP + D-ribose = ADP + D-ribose 5-phosphate. IEA GO:0004747 ribokinase activity GSVIVG01003583001 10962944 10963350 GSVIVG01017191001 5188188 5188633 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01024740001 7313389 7316218 GSVIVG01022590001 5620146 5621672 Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. IEA GO:0008171 O-methyltransferase activity GSVIVG01005320001 20696509 20713524 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01005320001 20696509 20713524 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01005320001 20696509 20713524 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01005320001 20696509 20713524 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023929001 2421825 2430563 GSVIVG01030645001 7428930 7431045 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01029159001 19013045 19013904 GSVIVG01019900001 4337077 4339299 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01031309001 489680 491623 GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA GSVIVG01031464001 18257605 18258772 GSVIVG01012636001 238997 242501 GO:0009228 thiamin biosynthetic process The chemical reactions and pathways resulting in the formation of thiamin (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01030156001 11112822 11113469 GSVIVG01000216001 16177167 16178863 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000216001 16177167 16178863 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000216001 16177167 16178863 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01000216001 16177167 16178863 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01000216001 16177167 16178863 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01000216001 16177167 16178863 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01000216001 16177167 16178863 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01000216001 16177167 16178863 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01013658001 2054380 2056628 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01013658001 2054380 2056628 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021797001 7260625 7262658 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01033451001 20602689 20603258 GSVIVG01029877001 887961 888497 GSVIVG01009385001 7918070 7925298 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. IEA GO:0004190 aspartic-type endopeptidase activity GSVIVG01003549001 14530486 14552213 GSVIVG01033191001 9387927 9388566 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01033191001 9387927 9388566 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01023900001 2588924 2591048 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01002482001 34998305 35001530 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01002482001 34998305 35001530 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01002482001 34998305 35001530 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01002482001 34998305 35001530 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010834001 23193193 23196309 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01010834001 23193193 23196309 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01010834001 23193193 23196309 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010834001 23193193 23196309 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008199001 4763218 4769124 Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01014240001 1836000 1843328 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01014240001 1836000 1843328 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01016499001 3366430 3371391 GO:0006189 'de novo' IMP biosynthetic process The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016499001 3366430 3371391 GO:0006189 'de novo' IMP biosynthetic process The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate. IEA Catalysis of the reaction: ATP + 5'-phosphoribosylformylglycinamide + L-glutamine + H2O = ADP + phosphate + 5'-phosphoribosylformylglycinamidine + L-glutamate. IEA GO:0004642 phosphoribosylformylglycinamidine synthase activity GSVIVG01034217001 12929611 12940011 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01025818001 11523279 11537241 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025521001 14354707 14358146 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025521001 14354707 14358146 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025521001 14354707 14358146 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01025521001 14354707 14358146 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025521001 14354707 14358146 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025521001 14354707 14358146 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025521001 14354707 14358146 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01025521001 14354707 14358146 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01025521001 14354707 14358146 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01025521001 14354707 14358146 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025521001 14354707 14358146 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025521001 14354707 14358146 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01013898001 6368529 6436142 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008031001 6471884 6479479 GSVIVG01016470001 3584211 3589264 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nucleotidyl group to a reactant. IEA GO:0016779 nucleotidyltransferase activity GSVIVG01025967001 26486550 26488330 GSVIVG01025562001 14033451 14039562 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01025562001 14033451 14039562 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01007651001 10834909 10835557 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01007651001 10834909 10835557 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01007651001 10834909 10835557 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01007651001 10834909 10835557 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01033385001 21037307 21039075 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01033385001 21037307 21039075 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01033385001 21037307 21039075 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01009644001 10148253 10149416 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01005266001 20016544 20020294 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01005266001 20016544 20020294 GO:0006821 chloride transport The directed movement of chloride into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01005266001 20016544 20020294 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01005266001 20016544 20020294 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01005266001 20016544 20020294 GO:0006821 chloride transport The directed movement of chloride into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01005266001 20016544 20020294 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01005266001 20016544 20020294 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01005266001 20016544 20020294 GO:0006821 chloride transport The directed movement of chloride into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01005266001 20016544 20020294 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01005266001 20016544 20020294 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a chloride ion by a voltage-gated channel. IEA GO:0005247 voltage-gated chloride channel activity GSVIVG01005266001 20016544 20020294 GO:0006821 chloride transport The directed movement of chloride into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a chloride ion by a voltage-gated channel. IEA GO:0005247 voltage-gated chloride channel activity GSVIVG01005266001 20016544 20020294 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a chloride ion by a voltage-gated channel. IEA GO:0005247 voltage-gated chloride channel activity GSVIVG01005266001 20016544 20020294 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01005266001 20016544 20020294 GO:0006821 chloride transport The directed movement of chloride into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01005266001 20016544 20020294 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01005454001 40321371 40321763 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01033005001 25017542 25022580 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033005001 25017542 25022580 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033005001 25017542 25022580 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033005001 25017542 25022580 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01033005001 25017542 25022580 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033005001 25017542 25022580 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033005001 25017542 25022580 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033005001 25017542 25022580 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01014311001 2541540 2543028 Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01014311001 2541540 2543028 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01017410001 8105664 8105989 GSVIVG01021745001 10435804 10437399 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021745001 10435804 10437399 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01021745001 10435804 10437399 Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01027531001 15959761 15961221 GSVIVG01025742001 12317537 12318011 GSVIVG01006653001 27250023 27251066 GSVIVG01033648001 18944918 18946844 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01031169001 1547404 1552321 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01030794001 16203487 16211913 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01030794001 16203487 16211913 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01030794001 16203487 16211913 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01023796001 3412165 3417863 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01023796001 3412165 3417863 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033959001 16291005 16310692 GSVIVG01038559001 21836491 21842723 GO:0009607 response to biotic stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism. IEA GSVIVG01038559001 21836491 21842723 GO:0009966 regulation of signal transduction Any process that modulates the frequency, rate or extent of signal transduction. IEA GSVIVG01035532001 2072164 2076177 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01035532001 2072164 2076177 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01035532001 2072164 2076177 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01035532001 2072164 2076177 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030974001 20100686 20103800 GSVIVG01030496001 6189770 6199506 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01034925001 149921 165528 GSVIVG01006948001 29226928 29228339 GSVIVG01019665001 2321151 2322831 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01009325001 7464764 7465436 GSVIVG01019958001 12386853 12392723 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01011817001 3874211 3875347 GSVIVG01027890001 9095910 9110102 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01027890001 9095910 9110102 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01027890001 9095910 9110102 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid. IEA GO:0008825 cyclopropane-fatty-acyl-phospholipid synthase activity GSVIVG01027890001 9095910 9110102 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid. IEA GO:0008825 cyclopropane-fatty-acyl-phospholipid synthase activity GSVIVG01027890001 9095910 9110102 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01027890001 9095910 9110102 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024050001 1492908 1494948 GSVIVG01026869001 19770806 19775219 GSVIVG01034943001 330302 332092 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01038711001 20709326 20726862 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01038711001 20709326 20726862 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01038711001 20709326 20726862 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01038711001 20709326 20726862 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01016883001 2240168 2241493 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. IEA GO:0016791 phosphatase activity GSVIVG01034380001 17148269 17157617 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01013378001 836207 838752 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01013378001 836207 838752 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01013378001 836207 838752 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01013378001 836207 838752 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017987001 5292307 5294612 GSVIVG01025074001 4762503 4766209 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01025074001 4762503 4766209 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01025074001 4762503 4766209 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01025074001 4762503 4766209 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01025074001 4762503 4766209 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01025074001 4762503 4766209 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01025074001 4762503 4766209 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01025074001 4762503 4766209 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01025074001 4762503 4766209 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025074001 4762503 4766209 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025074001 4762503 4766209 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01025074001 4762503 4766209 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01025074001 4762503 4766209 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces an oxygen molecule. IEA GO:0050664 oxidoreductase activity, acting on NADH or NADPH, with oxygen as acceptor GSVIVG01025074001 4762503 4766209 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces an oxygen molecule. IEA GO:0050664 oxidoreductase activity, acting on NADH or NADPH, with oxygen as acceptor GSVIVG01027196001 17127541 17129375 GSVIVG01020660001 3350003 3357932 GSVIVG01030090001 9753402 9756355 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01028387001 6961233 6964145 GSVIVG01015793001 17489219 17493481 GSVIVG01037841001 7287265 7291791 GSVIVG01034396001 16862666 16863953 GSVIVG01018360001 10394756 10407331 GSVIVG01021200001 2509884 2512161 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01021200001 2509884 2512161 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01034211001 14398774 14405247 GO:0006812 cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01034211001 14398774 14405247 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out). IEA GO:0015299 solute:hydrogen antiporter activity GSVIVG01023113001 22416960 22432819 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01023113001 22416960 22432819 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01023113001 22416960 22432819 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01023113001 22416960 22432819 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01023113001 22416960 22432819 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01023113001 22416960 22432819 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01023113001 22416960 22432819 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01023113001 22416960 22432819 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01023113001 22416960 22432819 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01023113001 22416960 22432819 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023113001 22416960 22432819 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023113001 22416960 22432819 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023113001 22416960 22432819 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023113001 22416960 22432819 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023113001 22416960 22432819 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019111001 16642152 16645742 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01003840001 20591509 20599705 GSVIVG01026389001 15488524 15488628 GSVIVG01019750001 2943365 2948362 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01022988001 17284109 17286856 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022988001 17284109 17286856 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009013001 4279192 4280442 GSVIVG01034412001 16618343 16619946 GSVIVG01038639001 21288395 21289333 GSVIVG01015364001 3021866 3031580 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015364001 3021866 3031580 GO:0006631 fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015364001 3021866 3031580 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015364001 3021866 3031580 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015364001 3021866 3031580 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor. IEA GO:0004368 glycerol-3-phosphate dehydrogenase activity GSVIVG01015364001 3021866 3031580 GO:0006631 fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor. IEA GO:0004368 glycerol-3-phosphate dehydrogenase activity GSVIVG01015364001 3021866 3031580 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor. IEA GO:0004368 glycerol-3-phosphate dehydrogenase activity GSVIVG01015364001 3021866 3031580 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of the reaction: sn-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor. IEA GO:0004368 glycerol-3-phosphate dehydrogenase activity GSVIVG01015364001 3021866 3031580 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01015364001 3021866 3031580 GO:0006631 fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01015364001 3021866 3031580 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01015364001 3021866 3031580 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01015364001 3021866 3031580 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01015364001 3021866 3031580 GO:0006631 fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01015364001 3021866 3031580 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01015364001 3021866 3031580 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01015364001 3021866 3031580 GO:0006072 glycerol-3-phosphate metabolic process The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01015364001 3021866 3031580 GO:0006631 fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01015364001 3021866 3031580 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01015364001 3021866 3031580 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0009331 glycerol-3-phosphate dehydrogenase complex An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01024440001 2595189 2608653 GSVIVG01001264001 4836974 4839409 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019716001 2662967 2685728 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005643 nuclear pore Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined. IEA GSVIVG01016727001 684354 690405 GSVIVG01017267001 6143362 6175320 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01017267001 6143362 6175320 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01017267001 6143362 6175320 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017267001 6143362 6175320 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017267001 6143362 6175320 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017267001 6143362 6175320 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017267001 6143362 6175320 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01017267001 6143362 6175320 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01018340001 10798618 10802774 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018340001 10798618 10802774 GO:0042777 plasma membrane ATP synthesis coupled proton transport The transport of protons across the plasma membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018340001 10798618 10802774 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01018340001 10798618 10802774 GO:0042777 plasma membrane ATP synthesis coupled proton transport The transport of protons across the plasma membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. IEA GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism GSVIVG01018340001 10798618 10802774 GO:0015986 ATP synthesis coupled proton transport The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01018340001 10798618 10802774 GO:0042777 plasma membrane ATP synthesis coupled proton transport The transport of protons across the plasma membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis. IEA GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. IEA GO:0046961 proton-transporting ATPase activity, rotational mechanism GSVIVG01019519001 1274105 1275209 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019519001 1274105 1275209 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01024938001 5882432 5888095 GSVIVG01035339001 617293 620149 GSVIVG01020700001 3014038 3014448 GSVIVG01002056001 32506221 32508546 GSVIVG01028950001 17157530 17157868 GSVIVG01003615001 11292477 11300159 GSVIVG01021006001 15501340 15501980 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with somatostatin to initiate a change in cell activity. IEA GO:0004994 somatostatin receptor activity GSVIVG01034945001 343990 346779 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01034945001 343990 346779 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01032562001 28379709 28382025 GSVIVG01013713001 8304090 8304305 GSVIVG01021617001 8166088 8208339 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01021617001 8166088 8208339 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01011999001 2312372 2313431 GSVIVG01001702001 12333546 12335687 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01001702001 12333546 12335687 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01001702001 12333546 12335687 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01001702001 12333546 12335687 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01001702001 12333546 12335687 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01023312001 19795331 19799542 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036180001 19748103 19749895 GSVIVG01024970001 5615789 5616779 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01035805001 4521975 4526248 GO:0001539 ciliary or flagellar motility Cell motility due to movement of cilia or flagella. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01035805001 4521975 4526248 GO:0001539 ciliary or flagellar motility Cell motility due to movement of cilia or flagella. IEA GO:0009428 bacterial-type flagellum basal body, distal rod, P ring One of the rings of the flagellar basal body; anchors the basal body to the peptidoglycan layer. Examples of this component are found in bacteria. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01035805001 4521975 4526248 GO:0001539 ciliary or flagellar motility Cell motility due to movement of cilia or flagella. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01035805001 4521975 4526248 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01035805001 4521975 4526248 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0009428 bacterial-type flagellum basal body, distal rod, P ring One of the rings of the flagellar basal body; anchors the basal body to the peptidoglycan layer. Examples of this component are found in bacteria. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01035805001 4521975 4526248 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01035805001 4521975 4526248 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01035805001 4521975 4526248 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0009428 bacterial-type flagellum basal body, distal rod, P ring One of the rings of the flagellar basal body; anchors the basal body to the peptidoglycan layer. Examples of this component are found in bacteria. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01035805001 4521975 4526248 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01035805001 4521975 4526248 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01035805001 4521975 4526248 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0009428 bacterial-type flagellum basal body, distal rod, P ring One of the rings of the flagellar basal body; anchors the basal body to the peptidoglycan layer. Examples of this component are found in bacteria. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01035805001 4521975 4526248 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01035805001 4521975 4526248 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01035805001 4521975 4526248 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0009428 bacterial-type flagellum basal body, distal rod, P ring One of the rings of the flagellar basal body; anchors the basal body to the peptidoglycan layer. Examples of this component are found in bacteria. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01035805001 4521975 4526248 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01035805001 4521975 4526248 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01035805001 4521975 4526248 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0009428 bacterial-type flagellum basal body, distal rod, P ring One of the rings of the flagellar basal body; anchors the basal body to the peptidoglycan layer. Examples of this component are found in bacteria. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01035805001 4521975 4526248 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01035805001 4521975 4526248 GO:0001539 ciliary or flagellar motility Cell motility due to movement of cilia or flagella. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01035805001 4521975 4526248 GO:0001539 ciliary or flagellar motility Cell motility due to movement of cilia or flagella. IEA GO:0009428 bacterial-type flagellum basal body, distal rod, P ring One of the rings of the flagellar basal body; anchors the basal body to the peptidoglycan layer. Examples of this component are found in bacteria. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01035805001 4521975 4526248 GO:0001539 ciliary or flagellar motility Cell motility due to movement of cilia or flagella. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01035805001 4521975 4526248 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01035805001 4521975 4526248 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0009428 bacterial-type flagellum basal body, distal rod, P ring One of the rings of the flagellar basal body; anchors the basal body to the peptidoglycan layer. Examples of this component are found in bacteria. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01035805001 4521975 4526248 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01035805001 4521975 4526248 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01035805001 4521975 4526248 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0009428 bacterial-type flagellum basal body, distal rod, P ring One of the rings of the flagellar basal body; anchors the basal body to the peptidoglycan layer. Examples of this component are found in bacteria. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01035805001 4521975 4526248 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01035805001 4521975 4526248 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01035805001 4521975 4526248 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0009428 bacterial-type flagellum basal body, distal rod, P ring One of the rings of the flagellar basal body; anchors the basal body to the peptidoglycan layer. Examples of this component are found in bacteria. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01035805001 4521975 4526248 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01035805001 4521975 4526248 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01035805001 4521975 4526248 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0009428 bacterial-type flagellum basal body, distal rod, P ring One of the rings of the flagellar basal body; anchors the basal body to the peptidoglycan layer. Examples of this component are found in bacteria. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01035805001 4521975 4526248 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01035805001 4521975 4526248 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01035805001 4521975 4526248 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0009428 bacterial-type flagellum basal body, distal rod, P ring One of the rings of the flagellar basal body; anchors the basal body to the peptidoglycan layer. Examples of this component are found in bacteria. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01035805001 4521975 4526248 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01035805001 4521975 4526248 GO:0001539 ciliary or flagellar motility Cell motility due to movement of cilia or flagella. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035805001 4521975 4526248 GO:0001539 ciliary or flagellar motility Cell motility due to movement of cilia or flagella. IEA GO:0009428 bacterial-type flagellum basal body, distal rod, P ring One of the rings of the flagellar basal body; anchors the basal body to the peptidoglycan layer. Examples of this component are found in bacteria. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035805001 4521975 4526248 GO:0001539 ciliary or flagellar motility Cell motility due to movement of cilia or flagella. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035805001 4521975 4526248 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035805001 4521975 4526248 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0009428 bacterial-type flagellum basal body, distal rod, P ring One of the rings of the flagellar basal body; anchors the basal body to the peptidoglycan layer. Examples of this component are found in bacteria. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035805001 4521975 4526248 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035805001 4521975 4526248 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035805001 4521975 4526248 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0009428 bacterial-type flagellum basal body, distal rod, P ring One of the rings of the flagellar basal body; anchors the basal body to the peptidoglycan layer. Examples of this component are found in bacteria. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035805001 4521975 4526248 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035805001 4521975 4526248 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035805001 4521975 4526248 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0009428 bacterial-type flagellum basal body, distal rod, P ring One of the rings of the flagellar basal body; anchors the basal body to the peptidoglycan layer. Examples of this component are found in bacteria. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035805001 4521975 4526248 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035805001 4521975 4526248 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035805001 4521975 4526248 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0009428 bacterial-type flagellum basal body, distal rod, P ring One of the rings of the flagellar basal body; anchors the basal body to the peptidoglycan layer. Examples of this component are found in bacteria. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035805001 4521975 4526248 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035805001 4521975 4526248 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035805001 4521975 4526248 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0009428 bacterial-type flagellum basal body, distal rod, P ring One of the rings of the flagellar basal body; anchors the basal body to the peptidoglycan layer. Examples of this component are found in bacteria. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035805001 4521975 4526248 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035805001 4521975 4526248 GO:0001539 ciliary or flagellar motility Cell motility due to movement of cilia or flagella. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01035805001 4521975 4526248 GO:0001539 ciliary or flagellar motility Cell motility due to movement of cilia or flagella. IEA GO:0009428 bacterial-type flagellum basal body, distal rod, P ring One of the rings of the flagellar basal body; anchors the basal body to the peptidoglycan layer. Examples of this component are found in bacteria. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01035805001 4521975 4526248 GO:0001539 ciliary or flagellar motility Cell motility due to movement of cilia or flagella. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01035805001 4521975 4526248 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01035805001 4521975 4526248 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0009428 bacterial-type flagellum basal body, distal rod, P ring One of the rings of the flagellar basal body; anchors the basal body to the peptidoglycan layer. Examples of this component are found in bacteria. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01035805001 4521975 4526248 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01035805001 4521975 4526248 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01035805001 4521975 4526248 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0009428 bacterial-type flagellum basal body, distal rod, P ring One of the rings of the flagellar basal body; anchors the basal body to the peptidoglycan layer. Examples of this component are found in bacteria. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01035805001 4521975 4526248 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01035805001 4521975 4526248 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01035805001 4521975 4526248 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0009428 bacterial-type flagellum basal body, distal rod, P ring One of the rings of the flagellar basal body; anchors the basal body to the peptidoglycan layer. Examples of this component are found in bacteria. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01035805001 4521975 4526248 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01035805001 4521975 4526248 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01035805001 4521975 4526248 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0009428 bacterial-type flagellum basal body, distal rod, P ring One of the rings of the flagellar basal body; anchors the basal body to the peptidoglycan layer. Examples of this component are found in bacteria. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01035805001 4521975 4526248 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01035805001 4521975 4526248 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01035805001 4521975 4526248 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0009428 bacterial-type flagellum basal body, distal rod, P ring One of the rings of the flagellar basal body; anchors the basal body to the peptidoglycan layer. Examples of this component are found in bacteria. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01035805001 4521975 4526248 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0030288 outer membrane-bounded periplasmic space The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01031774001 4270839 4271231 GSVIVG01031946001 5599272 5602934 GSVIVG01007845001 8423634 8438742 GSVIVG01028390001 6994565 6996717 GSVIVG01036311001 3683542 3692779 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01032772001 870992 876423 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01032772001 870992 876423 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01032772001 870992 876423 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01032772001 870992 876423 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032772001 870992 876423 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030033001 9006106 9010854 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01030033001 9006106 9010854 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01030033001 9006106 9010854 GO:0006435 threonyl-tRNA aminoacylation The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01030033001 9006106 9010854 GO:0043039 tRNA aminoacylation The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01030033001 9006106 9010854 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01030033001 9006106 9010854 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01030033001 9006106 9010854 GO:0006435 threonyl-tRNA aminoacylation The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01030033001 9006106 9010854 GO:0043039 tRNA aminoacylation The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01030033001 9006106 9010854 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr). IEA GO:0004829 threonine-tRNA ligase activity GSVIVG01030033001 9006106 9010854 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr). IEA GO:0004829 threonine-tRNA ligase activity GSVIVG01030033001 9006106 9010854 GO:0006435 threonyl-tRNA aminoacylation The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr). IEA GO:0004829 threonine-tRNA ligase activity GSVIVG01030033001 9006106 9010854 GO:0043039 tRNA aminoacylation The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr). IEA GO:0004829 threonine-tRNA ligase activity GSVIVG01030033001 9006106 9010854 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030033001 9006106 9010854 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030033001 9006106 9010854 GO:0006435 threonyl-tRNA aminoacylation The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030033001 9006106 9010854 GO:0043039 tRNA aminoacylation The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030033001 9006106 9010854 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances via a carbon-oxygen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate, to form aminoacyl-tRNA or a related compound. IEA GO:0016876 ligase activity, forming aminoacyl-tRNA and related compounds GSVIVG01030033001 9006106 9010854 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances via a carbon-oxygen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate, to form aminoacyl-tRNA or a related compound. IEA GO:0016876 ligase activity, forming aminoacyl-tRNA and related compounds GSVIVG01030033001 9006106 9010854 GO:0006435 threonyl-tRNA aminoacylation The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances via a carbon-oxygen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate, to form aminoacyl-tRNA or a related compound. IEA GO:0016876 ligase activity, forming aminoacyl-tRNA and related compounds GSVIVG01030033001 9006106 9010854 GO:0043039 tRNA aminoacylation The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the ligation of two substances via a carbon-oxygen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate, to form aminoacyl-tRNA or a related compound. IEA GO:0016876 ligase activity, forming aminoacyl-tRNA and related compounds GSVIVG01015977001 16716927 16727652 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01015977001 16716927 16727652 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01015977001 16716927 16727652 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01015977001 16716927 16727652 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008158001 5206885 5213522 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01008158001 5206885 5213522 GO:0006261 DNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01008158001 5206885 5213522 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and primer. IEA GO:0003887 DNA-directed DNA polymerase activity GSVIVG01008158001 5206885 5213522 GO:0006261 DNA-dependent DNA replication The process whereby new strands of DNA are synthesized, using parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and primer. IEA GO:0003887 DNA-directed DNA polymerase activity GSVIVG01017252001 5923170 5924770 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01028783001 18879627 18886900 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01028783001 18879627 18886900 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01028783001 18879627 18886900 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01028783001 18879627 18886900 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01028783001 18879627 18886900 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01004374001 38303121 38304303 Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01012045001 1824590 1838995 GSVIVG01011445001 29705633 29707686 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01032544001 28217378 28230502 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005578 proteinaceous extracellular matrix A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01032544001 28217378 28230502 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0031012 extracellular matrix A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as in plants). IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01032544001 28217378 28230502 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005578 proteinaceous extracellular matrix A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01032544001 28217378 28230502 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0031012 extracellular matrix A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as in plants). IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0004222 metalloendopeptidase activity GSVIVG01032544001 28217378 28230502 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0005578 proteinaceous extracellular matrix A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008237 metallopeptidase activity GSVIVG01032544001 28217378 28230502 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0031012 extracellular matrix A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as in plants). IEA Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008237 metallopeptidase activity GSVIVG01032544001 28217378 28230502 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005578 proteinaceous extracellular matrix A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus. IEA Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008237 metallopeptidase activity GSVIVG01032544001 28217378 28230502 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0031012 extracellular matrix A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as in plants). IEA Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008237 metallopeptidase activity GSVIVG01020675001 3189767 3190049 GSVIVG01031268001 676699 679647 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009654 oxygen evolving complex A complex, composed of a cluster of manganese, calcium and chloride ions bound to extrinsic proteins, that catalyzes the splitting of water to O2 and 4 H+. In cyanobacteria there are five extrinsic proteins in OEC (PsbO, PsbP-like, PsbQ-like, PsbU and PsbV), while in plants there are only three (PsbO, PsbP and PsbQ). IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01031268001 676699 679647 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0019898 extrinsic to membrane Loosely bound to one surface of a membrane, but not integrated into the hydrophobic region. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01014422001 3614864 3619201 GSVIVG01001184001 1029705 1033354 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01001184001 1029705 1033354 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01014127001 611536 620235 GSVIVG01032627001 2066712 2084982 GSVIVG01017432001 8457368 8466265 GSVIVG01008057001 6176484 6176741 GSVIVG01006513001 42582950 42584707 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01011282001 10494163 10494798 GSVIVG01017614001 2034188 2034683 GSVIVG01028373001 6762538 6773362 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028373001 6762538 6773362 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028373001 6762538 6773362 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01003443001 9971567 9972035 GSVIVG01038599001 21599919 21603635 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01004444001 38601066 38605471 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01004444001 38601066 38605471 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01013252001 6209000 6209468 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01003571001 14739469 14742604 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01003571001 14739469 14742604 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01003571001 14739469 14742604 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01003571001 14739469 14742604 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01003571001 14739469 14742604 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003571001 14739469 14742604 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003571001 14739469 14742604 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01003571001 14739469 14742604 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01022461001 3294600 3296510 Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01022461001 3294600 3296510 Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01022461001 3294600 3296510 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01022461001 3294600 3296510 Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01028907001 17658142 17659121 GSVIVG01022677001 14614997 14616258 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01022677001 14614997 14616258 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N2-methylguanine. IEA GO:0004809 tRNA (guanine-N2-)-methyltransferase activity GSVIVG01010448001 20701556 20702206 GO:0006465 signal peptide processing The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell. IEA GO:0005787 signal peptidase complex A protein complex that is located in the endoplasmic reticulum membrane and cleaves the signal sequence from precursor proteins following their transport out of the cytoplasmic space. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01010448001 20701556 20702206 GO:0006465 signal peptide processing The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01006384001 25531616 25538198 GSVIVG01017403001 7961037 7962098 GSVIVG01011755001 4477428 4478586 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01010735001 21924402 21956033 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01010735001 21924402 21956033 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01010735001 21924402 21956033 GO:0006428 isoleucyl-tRNA aminoacylation The process of coupling isoleucine to isoleucyl-tRNA, catalyzed by isoleucyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01010735001 21924402 21956033 GO:0006438 valyl-tRNA aminoacylation The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01010735001 21924402 21956033 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01010735001 21924402 21956033 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01010735001 21924402 21956033 GO:0006428 isoleucyl-tRNA aminoacylation The process of coupling isoleucine to isoleucyl-tRNA, catalyzed by isoleucyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01010735001 21924402 21956033 GO:0006438 valyl-tRNA aminoacylation The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. IEA GO:0004812 aminoacyl-tRNA ligase activity GSVIVG01010735001 21924402 21956033 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile). IEA GO:0004822 isoleucine-tRNA ligase activity GSVIVG01010735001 21924402 21956033 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile). IEA GO:0004822 isoleucine-tRNA ligase activity GSVIVG01010735001 21924402 21956033 GO:0006428 isoleucyl-tRNA aminoacylation The process of coupling isoleucine to isoleucyl-tRNA, catalyzed by isoleucyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile). IEA GO:0004822 isoleucine-tRNA ligase activity GSVIVG01010735001 21924402 21956033 GO:0006438 valyl-tRNA aminoacylation The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile). IEA GO:0004822 isoleucine-tRNA ligase activity GSVIVG01010735001 21924402 21956033 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val). IEA GO:0004832 valine-tRNA ligase activity GSVIVG01010735001 21924402 21956033 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val). IEA GO:0004832 valine-tRNA ligase activity GSVIVG01010735001 21924402 21956033 GO:0006428 isoleucyl-tRNA aminoacylation The process of coupling isoleucine to isoleucyl-tRNA, catalyzed by isoleucyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val). IEA GO:0004832 valine-tRNA ligase activity GSVIVG01010735001 21924402 21956033 GO:0006438 valyl-tRNA aminoacylation The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val). IEA GO:0004832 valine-tRNA ligase activity GSVIVG01010735001 21924402 21956033 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010735001 21924402 21956033 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010735001 21924402 21956033 GO:0006428 isoleucyl-tRNA aminoacylation The process of coupling isoleucine to isoleucyl-tRNA, catalyzed by isoleucyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010735001 21924402 21956033 GO:0006438 valyl-tRNA aminoacylation The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010735001 21924402 21956033 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01010735001 21924402 21956033 GO:0006418 tRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01010735001 21924402 21956033 GO:0006428 isoleucyl-tRNA aminoacylation The process of coupling isoleucine to isoleucyl-tRNA, catalyzed by isoleucyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01010735001 21924402 21956033 GO:0006438 valyl-tRNA aminoacylation The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01017911001 4559702 4563672 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA Catalysis of the reaction: ATP + alpha-D-glucose 1-phosphate = diphosphate + ADP-glucose. IEA GO:0008878 glucose-1-phosphate adenylyltransferase activity GSVIVG01017911001 4559702 4563672 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: ATP + alpha-D-glucose 1-phosphate = diphosphate + ADP-glucose. IEA GO:0008878 glucose-1-phosphate adenylyltransferase activity GSVIVG01017911001 4559702 4563672 GO:0005978 glycogen biosynthetic process The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. IEA Catalysis of the transfer of a nucleotidyl group to a reactant. IEA GO:0016779 nucleotidyltransferase activity GSVIVG01017911001 4559702 4563672 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nucleotidyl group to a reactant. IEA GO:0016779 nucleotidyltransferase activity GSVIVG01038011001 12545889 12562513 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01038011001 12545889 12562513 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01038011001 12545889 12562513 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01038011001 12545889 12562513 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01038011001 12545889 12562513 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036793001 22499713 22500162 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030933001 19302705 19304603 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01030933001 19302705 19304603 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. IEA GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity GSVIVG01030933001 19302705 19304603 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01030933001 19302705 19304603 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01028009001 3173747 3174613 GSVIVG01006711001 27697496 27712215 GO:0032312 regulation of ARF GTPase activity Any process that modulates the activity of the GTPase ARF. IEA Increases the rate of GTP hydrolysis by the GTPase ARF. IEA GO:0008060 ARF GTPase activator activity GSVIVG01006711001 27697496 27712215 GO:0032312 regulation of ARF GTPase activity Any process that modulates the activity of the GTPase ARF. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01020301001 21696838 21712562 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01020301001 21696838 21712562 GO:0006268 DNA unwinding involved in replication The process by which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01020301001 21696838 21712562 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle. IEA GO:0003917 DNA topoisomerase type I activity GSVIVG01020301001 21696838 21712562 GO:0006268 DNA unwinding involved in replication The process by which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle. IEA GO:0003917 DNA topoisomerase type I activity GSVIVG01020301001 21696838 21712562 GO:0006265 DNA topological change The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. IEA GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity GSVIVG01020301001 21696838 21712562 GO:0006268 DNA unwinding involved in replication The process by which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2. IEA GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity GSVIVG01036521001 23017927 23019240 GSVIVG01016051001 17951264 17962981 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GSVIVG01037227001 27682645 27701721 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01037227001 27682645 27701721 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01037227001 27682645 27701721 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01037227001 27682645 27701721 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019117001 16599413 16607622 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01018224001 12967748 12988542 GSVIVG01012270001 12818689 12824728 GSVIVG01028826001 18325242 18328692 GSVIVG01010487001 21006608 21012278 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01010487001 21006608 21012278 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01023827001 3165259 3173838 GSVIVG01015123001 1199154 1205045 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015123001 1199154 1205045 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the ligation of ammonia (NH3) to another substance via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. IEA GO:0016211 ammonia ligase activity GSVIVG01020241001 8666041 8668402 GSVIVG01003742001 7553066 7553481 GSVIVG01004837001 5537681 5537878 GSVIVG01001925001 14858891 14860885 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0000808 origin recognition complex A multisubunit complex that is located at the replication origins of a chromosome. IEA GSVIVG01001925001 14858891 14860885 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA GSVIVG01024076001 1298169 1302974 GSVIVG01013277001 5723377 5725314 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01013277001 5723377 5725314 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01013277001 5723377 5725314 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01013277001 5723377 5725314 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030518001 6423386 6425856 GSVIVG01029788001 14695782 14704381 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. IEA GO:0016836 hydro-lyase activity GSVIVG01024773001 7071506 7074719 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01004077001 14600471 14603490 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01004077001 14600471 14603490 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01004077001 14600471 14603490 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01004077001 14600471 14603490 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01002907001 37193696 37195699 GO:0006487 protein amino acid N-linked glycosylation A protein amino acid glycosylation process in which a sugar unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan. IEA GO:0000139 Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus. IEA Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + alpha-D-mannosyl-1,3-(R1)-beta-D-mannosyl-R2 = UDP + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(R1)-beta-D-mannosyl-R2. IEA GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity GSVIVG01029422001 17035438 17036082 GSVIVG01023898001 2595897 2600151 GSVIVG01008868001 2911982 2914912 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01021836001 6684455 6687270 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01021836001 6684455 6687270 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01021377001 4633451 4636960 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01021377001 4633451 4636960 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01028396001 7095879 7099623 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01028396001 7095879 7099623 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01028396001 7095879 7099623 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01028396001 7095879 7099623 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01028396001 7095879 7099623 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001699001 12209635 12212696 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01001699001 12209635 12212696 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01001699001 12209635 12212696 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01001699001 12209635 12212696 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01001699001 12209635 12212696 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001699001 12209635 12212696 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01032591001 28634497 28636524 GSVIVG01019607001 1900757 1904873 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036609001 19146817 19160119 GSVIVG01033724001 18326470 18334223 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01033724001 18326470 18334223 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01033724001 18326470 18334223 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01017371001 7476752 7483869 GSVIVG01035872001 5099761 5106142 GO:0006168 adenine salvage Any process that generates adenine, 6-aminopurine, from derivatives of it without de novo synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate. IEA GO:0003999 adenine phosphoribosyltransferase activity GSVIVG01035872001 5099761 5106142 GO:0009116 nucleoside metabolic process The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine). IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate. IEA GO:0003999 adenine phosphoribosyltransferase activity GSVIVG01007371001 31552754 31561139 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007371001 31552754 31561139 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007371001 31552754 31561139 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007371001 31552754 31561139 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01007371001 31552754 31561139 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01007371001 31552754 31561139 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01007371001 31552754 31561139 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01007371001 31552754 31561139 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01007371001 31552754 31561139 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01007371001 31552754 31561139 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01007371001 31552754 31561139 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01007371001 31552754 31561139 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01007371001 31552754 31561139 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01007371001 31552754 31561139 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01007371001 31552754 31561139 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01007371001 31552754 31561139 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01007371001 31552754 31561139 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01007371001 31552754 31561139 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01007371001 31552754 31561139 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007371001 31552754 31561139 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007371001 31552754 31561139 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01007371001 31552754 31561139 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01007371001 31552754 31561139 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01007371001 31552754 31561139 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01022368001 19143879 19154710 Catalysis of the transfer of the amide nitrogen of glutamine to a variety of substrates. GATases catalyze two separate reactions at two active sites, which are located either on a single polypeptide chain or on different subunits. In the glutaminase reaction, glutamine is hydrolyzed to glutamate and ammonia, which is added to an acceptor substrate in the synthase reaction. IEA GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor GSVIVG01003099001 8678866 8681135 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01003099001 8678866 8681135 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009680001 10395350 10398504 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01009680001 10395350 10398504 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01009680001 10395350 10398504 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01009680001 10395350 10398504 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01018081001 6320701 6323533 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018081001 6320701 6323533 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018081001 6320701 6323533 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018081001 6320701 6323533 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01018081001 6320701 6323533 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01018081001 6320701 6323533 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01018081001 6320701 6323533 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. IEA GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GSVIVG01018081001 6320701 6323533 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. IEA GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GSVIVG01018081001 6320701 6323533 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. IEA GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GSVIVG01018081001 6320701 6323533 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01018081001 6320701 6323533 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01018081001 6320701 6323533 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01029862001 687897 689024 GSVIVG01004664001 39455636 39456713 GSVIVG01016726001 676676 682751 GSVIVG01036111001 20561699 20568776 GO:0006596 polyamine biosynthetic process The chemical reactions and pathways resulting in the formation of polyamines, any organic compound containing two or more amino groups. IEA Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. IEA GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GSVIVG01036111001 20561699 20568776 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. IEA GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GSVIVG01036111001 20561699 20568776 GO:0006596 polyamine biosynthetic process The chemical reactions and pathways resulting in the formation of polyamines, any organic compound containing two or more amino groups. IEA Catalysis of the reaction: H2O + N-carbamoylputrescine = NH3 + CO2 + putrescine. IEA GO:0050126 N-carbamoylputrescine amidase activity GSVIVG01036111001 20561699 20568776 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA Catalysis of the reaction: H2O + N-carbamoylputrescine = NH3 + CO2 + putrescine. IEA GO:0050126 N-carbamoylputrescine amidase activity GSVIVG01008927001 3445760 3445939 GSVIVG01028987001 10138315 10141541 GSVIVG01023833001 3112735 3116384 GSVIVG01019468001 886305 886815 GSVIVG01034917001 113783 123742 GSVIVG01003041001 37604609 37606062 GSVIVG01027217001 18052776 18069072 GSVIVG01003763001 12470839 12478780 GSVIVG01006277001 24451343 24452062 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01006277001 24451343 24452062 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01005282001 438924 474834 GSVIVG01011863001 3467056 3473568 GSVIVG01006598001 26969786 26972569 GSVIVG01006709001 27685990 27689869 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01006709001 27685990 27689869 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01006709001 27685990 27689869 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01033422001 20842533 20848070 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor). IEA GO:0004659 prenyltransferase activity GSVIVG01012869001 6377416 6378932 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01012869001 6377416 6378932 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01019464001 854452 855538 GSVIVG01029374001 15675901 15676431 GSVIVG01013391001 761517 764467 GSVIVG01009125001 5294141 5304835 GO:0008615 pyridoxine biosynthetic process The chemical reactions and pathways resulting in the formation of pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, one of the vitamin B6 compounds. IEA Catalysis of the reaction: pyridoxamine 5'-phosphate + H2O + O2 = pyridoxal 5'-phosphate + NH3 + H2O2. IEA GO:0004733 pyridoxamine-phosphate oxidase activity GSVIVG01009125001 5294141 5304835 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: pyridoxamine 5'-phosphate + H2O + O2 = pyridoxal 5'-phosphate + NH3 + H2O2. IEA GO:0004733 pyridoxamine-phosphate oxidase activity GSVIVG01009125001 5294141 5304835 GO:0008615 pyridoxine biosynthetic process The chemical reactions and pathways resulting in the formation of pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, one of the vitamin B6 compounds. IEA Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0010181 FMN binding GSVIVG01009125001 5294141 5304835 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0010181 FMN binding GSVIVG01009125001 5294141 5304835 GO:0008615 pyridoxine biosynthetic process The chemical reactions and pathways resulting in the formation of pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, one of the vitamin B6 compounds. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors GSVIVG01009125001 5294141 5304835 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. IEA GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors GSVIVG01027987001 3011859 3018835 GSVIVG01010160001 16556738 16559153 GSVIVG01036907001 17854733 17865483 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01028768001 19047647 19073952 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01028768001 19047647 19073952 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014733001 9060515 9063661 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01014733001 9060515 9063661 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014733001 9060515 9063661 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01014733001 9060515 9063661 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01031139001 1805571 1811605 GSVIVG01008765001 1784960 1786659 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008765001 1784960 1786659 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008765001 1784960 1786659 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008765001 1784960 1786659 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008765001 1784960 1786659 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008765001 1784960 1786659 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008765001 1784960 1786659 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008765001 1784960 1786659 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01016568001 2717148 2717788 GSVIVG01012041001 1902382 1918897 GSVIVG01030378001 5106246 5108994 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01005261001 19969425 19972600 GSVIVG01007790001 8991057 8992372 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01007790001 8991057 8992372 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt. IEA GO:0004525 ribonuclease III activity GSVIVG01019868001 4020867 4025226 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01019868001 4020867 4025226 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01019868001 4020867 4025226 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01019868001 4020867 4025226 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01019868001 4020867 4025226 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001154001 1230937 1249129 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA The catalysis of certain rearrangements of a molecule to break or form a ring. IEA GO:0016872 intramolecular lyase activity GSVIVG01001154001 1230937 1249129 GO:0042398 cellular amino acid derivative biosynthetic process The chemical reactions and pathways resulting in the formation of compounds derived from amino acids, organic acids containing one or more amino substituents. IEA The catalysis of certain rearrangements of a molecule to break or form a ring. IEA GO:0016872 intramolecular lyase activity GSVIVG01001154001 1230937 1249129 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA The catalysis of certain rearrangements of a molecule to break or form a ring. IEA GO:0016872 intramolecular lyase activity GSVIVG01001154001 1230937 1249129 GO:0042309 homoiothermy Any homoeostatic process by which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01001154001 1230937 1249129 GO:0042398 cellular amino acid derivative biosynthetic process The chemical reactions and pathways resulting in the formation of compounds derived from amino acids, organic acids containing one or more amino substituents. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01001154001 1230937 1249129 GO:0050826 response to freezing A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius. IEA Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal. IEA GO:0050825 ice binding GSVIVG01014444001 3843834 3846216 GSVIVG01026157001 13123742 13128460 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01027022001 18512769 18522187 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027022001 18512769 18522187 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027022001 18512769 18522187 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01027022001 18512769 18522187 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01027022001 18512769 18522187 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01027022001 18512769 18522187 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01027022001 18512769 18522187 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01027022001 18512769 18522187 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01012689001 662322 665329 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA GSVIVG01012689001 662322 665329 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01000879001 3170545 3174379 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000879001 3170545 3174379 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000879001 3170545 3174379 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000879001 3170545 3174379 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022099001 16579480 16582728 GSVIVG01035883001 5239403 5245891 GSVIVG01032732001 1204316 1205102 GSVIVG01017961001 5098465 5099793 GSVIVG01019017001 17705304 17707037 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01021290001 3544616 3550646 GSVIVG01024799001 6848583 6850752 GSVIVG01016857001 2034886 2041795 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01016857001 2034886 2041795 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01016857001 2034886 2041795 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01016857001 2034886 2041795 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029824001 115793 118526 GSVIVG01019142001 16283373 16291482 GSVIVG01005637001 20778301 20779277 GSVIVG01012552001 1206014 1209101 GSVIVG01013162001 7366546 7368528 GSVIVG01003609001 11216487 11217838 GSVIVG01027930001 9621838 9626257 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01027930001 9621838 9626257 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01003837001 20538224 20543019 GO:0006099 tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01003837001 20538224 20543019 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01003837001 20538224 20543019 GO:0006099 tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of the reaction: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH + H+. IEA GO:0004449 isocitrate dehydrogenase (NAD+) activity GSVIVG01003837001 20538224 20543019 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of the reaction: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH + H+. IEA GO:0004449 isocitrate dehydrogenase (NAD+) activity GSVIVG01003837001 20538224 20543019 GO:0006099 tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01003837001 20538224 20543019 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01003837001 20538224 20543019 GO:0006099 tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01003837001 20538224 20543019 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0051287 NAD or NADH binding GSVIVG01012051001 1779062 1780886 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01012051001 1779062 1780886 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01012051001 1779062 1780886 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0008236 serine-type peptidase activity GSVIVG01012051001 1779062 1780886 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01011540001 12756222 12764275 GSVIVG01034161001 14745196 14759825 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01034161001 14745196 14759825 Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA. IEA GO:0004540 ribonuclease activity GSVIVG01022259001 17958306 17960930 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01022259001 17958306 17960930 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01021442001 5390002 5390679 GSVIVG01019230001 3024146 3024259 GSVIVG01022719001 15547815 15557175 GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. IEA Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. IEA GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GSVIVG01032223001 13283207 13284258 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01032223001 13283207 13284258 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021378001 4638513 4653548 GO:0006364 rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Catalysis of the transfer of a nucleotidyl group to a reactant. IEA GO:0016779 nucleotidyltransferase activity GSVIVG01021378001 4638513 4653548 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Catalysis of the transfer of a nucleotidyl group to a reactant. IEA GO:0016779 nucleotidyltransferase activity GSVIVG01021378001 4638513 4653548 GO:0006364 rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with any part of a ribosome. IEA GO:0043022 ribosome binding GSVIVG01021378001 4638513 4653548 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA Interacting selectively and non-covalently with any part of a ribosome. IEA GO:0043022 ribosome binding GSVIVG01025372001 1288327 1347015 GSVIVG01008812001 2352063 2359074 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01008812001 2352063 2359074 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01008812001 2352063 2359074 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01008812001 2352063 2359074 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01008812001 2352063 2359074 GO:0009060 aerobic respiration The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01008812001 2352063 2359074 GO:0009060 aerobic respiration The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01008812001 2352063 2359074 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01008812001 2352063 2359074 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01008812001 2352063 2359074 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01008812001 2352063 2359074 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01008812001 2352063 2359074 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01008812001 2352063 2359074 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01008812001 2352063 2359074 GO:0009060 aerobic respiration The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01008812001 2352063 2359074 GO:0009060 aerobic respiration The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01008812001 2352063 2359074 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01008812001 2352063 2359074 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01008812001 2352063 2359074 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01008812001 2352063 2359074 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01008812001 2352063 2359074 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01008812001 2352063 2359074 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01008812001 2352063 2359074 GO:0009060 aerobic respiration The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01008812001 2352063 2359074 GO:0009060 aerobic respiration The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01008812001 2352063 2359074 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01008812001 2352063 2359074 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01008812001 2352063 2359074 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01008812001 2352063 2359074 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01008812001 2352063 2359074 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01008812001 2352063 2359074 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01008812001 2352063 2359074 GO:0009060 aerobic respiration The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01008812001 2352063 2359074 GO:0009060 aerobic respiration The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01008812001 2352063 2359074 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01008812001 2352063 2359074 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01015703001 15940751 15957435 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01009363001 7787289 7788777 GSVIVG01008222001 4509162 4510718 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). IEA GO:0003755 peptidyl-prolyl cis-trans isomerase activity GSVIVG01022238001 17758348 17760860 Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01022238001 17758348 17760860 Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01022238001 17758348 17760860 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01022238001 17758348 17760860 Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01005293001 20328828 20331052 GSVIVG01036691001 23824657 23827974 GSVIVG01011650001 5599548 5605308 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01011650001 5599548 5605308 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01011650001 5599548 5605308 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01011650001 5599548 5605308 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01011650001 5599548 5605308 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01011650001 5599548 5605308 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01004251001 37674950 37677151 GSVIVG01018663001 11494880 11495563 GO:0016559 peroxisome fission The division of a mature peroxisome within a cell to form two or more separate peroxisome compartments. IEA GO:0005778 peroxisomal membrane The lipid bilayer surrounding a peroxisome. IEA GSVIVG01009740001 10904686 10904968 GSVIVG01008235001 4309791 4334309 GO:0006298 mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. IEA GO:0032301 MutSalpha complex A heterodimer involved in the recognition and repair of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MSH2 and MSH6. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008235001 4309791 4334309 GO:0006298 mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. IEA GO:0032302 MutSbeta complex A heterodimer involved in binding to and correcting insertion/deletion mutations. In human the complex consists of two subunits, MSH2 and MSH3. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008235001 4309791 4334309 GO:0006298 mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. IEA GO:0032301 MutSalpha complex A heterodimer involved in the recognition and repair of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MSH2 and MSH6. IEA Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches. IEA GO:0030983 mismatched DNA binding GSVIVG01008235001 4309791 4334309 GO:0006298 mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. IEA GO:0032302 MutSbeta complex A heterodimer involved in binding to and correcting insertion/deletion mutations. In human the complex consists of two subunits, MSH2 and MSH3. IEA Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches. IEA GO:0030983 mismatched DNA binding GSVIVG01025455001 732503 733217 GSVIVG01003958001 14054761 14056730 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01020929001 16975518 16977637 GSVIVG01001851001 26301120 26309201 GSVIVG01027007001 18608440 18613460 GO:0007205 activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway The initiation of the activity of the inactive enzyme protein kinase C as the result of a series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027007001 18608440 18613460 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027007001 18608440 18613460 GO:0007205 activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway The initiation of the activity of the inactive enzyme protein kinase C as the result of a series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol 3-phosphate. IEA GO:0004143 diacylglycerol kinase activity GSVIVG01027007001 18608440 18613460 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol 3-phosphate. IEA GO:0004143 diacylglycerol kinase activity GSVIVG01015542001 4696541 4699271 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015542001 4696541 4699271 GO:0046470 phosphatidylcholine metabolic process The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015542001 4696541 4699271 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate. IEA GO:0004630 phospholipase D activity GSVIVG01015542001 4696541 4699271 GO:0046470 phosphatidylcholine metabolic process The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate. IEA GO:0004630 phospholipase D activity GSVIVG01015542001 4696541 4699271 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01015542001 4696541 4699271 GO:0046470 phosphatidylcholine metabolic process The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01033606001 19365616 19382450 GSVIVG01028744001 19218947 19224345 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01028744001 19218947 19224345 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01028744001 19218947 19224345 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028744001 19218947 19224345 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028744001 19218947 19224345 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01028744001 19218947 19224345 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01028744001 19218947 19224345 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01028744001 19218947 19224345 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01028744001 19218947 19224345 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01028744001 19218947 19224345 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the active transport of a substance across a membrane. IEA GO:0042626 ATPase activity, coupled to transmembrane movement of substances GSVIVG01025162001 3838840 3845837 GO:0008219 cell death A biological process that results in permanent cessation of all vital functions of a cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01015875001 18825277 18826651 GSVIVG01024582001 8649080 8650908 GSVIVG01018381001 10033056 10039619 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018381001 10033056 10039619 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01008170001 5125970 5136309 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01008170001 5125970 5136309 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008565001 842043 844361 GO:0016068 type I hypersensitivity An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells or basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines. IEA GSVIVG01030240001 9982756 10013357 GO:0009252 peptidoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01030240001 9982756 10013357 GO:0009252 peptidoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030240001 9982756 10013357 GO:0009252 peptidoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the reaction: ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. IEA GO:0008716 D-alanine-D-alanine ligase activity GSVIVG01031567001 18260680 18285830 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030127 COPII vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031567001 18260680 18285830 GO:0006888 ER to Golgi vesicle-mediated transport The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi. IEA GO:0030127 COPII vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031567001 18260680 18285830 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0030127 COPII vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01031567001 18260680 18285830 GO:0006888 ER to Golgi vesicle-mediated transport The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi. IEA GO:0030127 COPII vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01027381001 15494772 15497724 GSVIVG01035138001 1785715 1788540 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01036283001 7563304 7565485 The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01036007001 7106563 7110294 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of hydroxylation at the 7-methyl group of chlorophyllide a, according to the reactions: chlorophyllide a + O2 + NADPH + H+ = 7-hydroxychlorophyllide a + H2O + NADP+ and 7-hydroxychlorophyllide a + O2 + NADPH + H+ = chlorophyllide b + 2 H2O + NADP+. IEA GO:0010277 chlorophyllide a oxygenase activity GSVIVG01036007001 7106563 7110294 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01036007001 7106563 7110294 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. IEA GO:0051537 2 iron, 2 sulfur cluster binding GSVIVG01031364001 3387 4364 GSVIVG01007940001 7320789 7323760 GSVIVG01025366001 1424090 1425049 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025366001 1424090 1425049 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01014851001 10569070 10570617 GSVIVG01013608001 1284866 1301072 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01013608001 1284866 1301072 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01013608001 1284866 1301072 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01013608001 1284866 1301072 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013608001 1284866 1301072 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006760001 28226132 28232428 GSVIVG01026112001 24450715 24453970 GSVIVG01016951001 2903493 2906826 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016951001 2903493 2906826 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016951001 2903493 2906826 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016951001 2903493 2906826 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016951001 2903493 2906826 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016951001 2903493 2906826 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016951001 2903493 2906826 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016951001 2903493 2906826 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016951001 2903493 2906826 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01016951001 2903493 2906826 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01016951001 2903493 2906826 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01016951001 2903493 2906826 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01016951001 2903493 2906826 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01016951001 2903493 2906826 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01016951001 2903493 2906826 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01016951001 2903493 2906826 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01016951001 2903493 2906826 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01016951001 2903493 2906826 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01016951001 2903493 2906826 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01016951001 2903493 2906826 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01016951001 2903493 2906826 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01016951001 2903493 2906826 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01016951001 2903493 2906826 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01016951001 2903493 2906826 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01016951001 2903493 2906826 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01016951001 2903493 2906826 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01016951001 2903493 2906826 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01016951001 2903493 2906826 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01016951001 2903493 2906826 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01016951001 2903493 2906826 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01016951001 2903493 2906826 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01016951001 2903493 2906826 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01016951001 2903493 2906826 GO:0015904 tetracycline transport The directed movement of tetracycline into, out of, within or between cells by means of some external agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01016951001 2903493 2906826 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01016951001 2903493 2906826 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01016951001 2903493 2906826 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). IEA GO:0015520 tetracycline:hydrogen antiporter activity GSVIVG01001276001 4914168 4914984 GSVIVG01033386001 21027283 21034325 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01033386001 21027283 21034325 Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. IEA GO:0004519 endonuclease activity GSVIVG01026604001 21142199 21144587 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01038742001 331940 335172 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01038742001 331940 335172 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01038742001 331940 335172 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01038742001 331940 335172 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01038742001 331940 335172 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01038742001 331940 335172 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out). IEA GO:0004008 copper-exporting ATPase activity GSVIVG01038742001 331940 335172 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038742001 331940 335172 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038742001 331940 335172 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038742001 331940 335172 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate in the presence of single- or double-stranded DNA; drives another reaction. IEA GO:0008094 DNA-dependent ATPase activity GSVIVG01038742001 331940 335172 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate in the presence of single- or double-stranded DNA; drives another reaction. IEA GO:0008094 DNA-dependent ATPase activity GSVIVG01038742001 331940 335172 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate in the presence of single- or double-stranded DNA; drives another reaction. IEA GO:0008094 DNA-dependent ATPase activity GSVIVG01038742001 331940 335172 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01038742001 331940 335172 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01038742001 331940 335172 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01038742001 331940 335172 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01038742001 331940 335172 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01038742001 331940 335172 GO:0006825 copper ion transport The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01036107001 20588122 20588676 GO:0009269 response to desiccation A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a desiccation stimulus, extreme dryness resulting from the prolonged deprivation of water. IEA GSVIVG01019497001 1105169 1112931 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01030573001 6845399 6847569 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines. IEA GO:0005542 folic acid binding GSVIVG01030573001 6845399 6847569 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01030280001 9528563 9546919 GO:0000724 double-strand break repair via homologous recombination The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with single-stranded DNA. IEA GO:0003697 single-stranded DNA binding GSVIVG01030280001 9528563 9546919 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with single-stranded DNA. IEA GO:0003697 single-stranded DNA binding GSVIVG01030280001 9528563 9546919 GO:0007090 regulation of S phase of mitotic cell cycle A cell cycle process that modulates the frequency, rate or extent of the progression through the S phase of the mitotic cell cycle. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with single-stranded DNA. IEA GO:0003697 single-stranded DNA binding GSVIVG01030280001 9528563 9546919 GO:0000724 double-strand break repair via homologous recombination The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030280001 9528563 9546919 GO:0006310 DNA recombination Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01030280001 9528563 9546919 GO:0007090 regulation of S phase of mitotic cell cycle A cell cycle process that modulates the frequency, rate or extent of the progression through the S phase of the mitotic cell cycle. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01026011001 25886258 25888623 GSVIVG01012491001 13836989 13837108 GSVIVG01013214001 6679456 6679611 GSVIVG01008866001 2905700 2907507 GSVIVG01001785001 3080985 3081614 GSVIVG01009690001 10510992 10513631 GSVIVG01029132001 19292737 19300917 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01029132001 19292737 19300917 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01029132001 19292737 19300917 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01029132001 19292737 19300917 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01008505001 1280791 1285398 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01008505001 1280791 1285398 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01008505001 1280791 1285398 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Catalysis of the reaction: ATP + AMP = 2 ADP. IEA GO:0004017 adenylate kinase activity GSVIVG01008505001 1280791 1285398 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Catalysis of the reaction: ATP + AMP = 2 ADP. IEA GO:0004017 adenylate kinase activity GSVIVG01008505001 1280791 1285398 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008505001 1280791 1285398 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008505001 1280791 1285398 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a phosphate group (acceptor). IEA GO:0016776 phosphotransferase activity, phosphate group as acceptor GSVIVG01008505001 1280791 1285398 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a phosphate group (acceptor). IEA GO:0016776 phosphotransferase activity, phosphate group as acceptor GSVIVG01008505001 1280791 1285398 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Catalysis of the reaction: ATP + nucleoside monophosphate = ADP + nucleoside diphosphate. IEA GO:0019201 nucleotide kinase activity GSVIVG01008505001 1280791 1285398 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Catalysis of the reaction: ATP + nucleoside monophosphate = ADP + nucleoside diphosphate. IEA GO:0019201 nucleotide kinase activity GSVIVG01008505001 1280791 1285398 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate. IEA GO:0019205 nucleobase, nucleoside, nucleotide kinase activity GSVIVG01008505001 1280791 1285398 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate. IEA GO:0019205 nucleobase, nucleoside, nucleotide kinase activity GSVIVG01003547001 14517830 14519654 GSVIVG01003381001 9654717 9703553 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01003381001 9654717 9703553 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01003381001 9654717 9703553 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01003381001 9654717 9703553 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01003381001 9654717 9703553 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the movement of phospholipids from one membrane face to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP. IEA GO:0004012 phospholipid-translocating ATPase activity GSVIVG01003381001 9654717 9703553 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the movement of phospholipids from one membrane face to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP. IEA GO:0004012 phospholipid-translocating ATPase activity GSVIVG01003381001 9654717 9703553 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the movement of phospholipids from one membrane face to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP. IEA GO:0004012 phospholipid-translocating ATPase activity GSVIVG01003381001 9654717 9703553 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the movement of phospholipids from one membrane face to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP. IEA GO:0004012 phospholipid-translocating ATPase activity GSVIVG01003381001 9654717 9703553 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003381001 9654717 9703553 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003381001 9654717 9703553 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003381001 9654717 9703553 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003381001 9654717 9703553 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01003381001 9654717 9703553 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01003381001 9654717 9703553 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01003381001 9654717 9703553 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01003381001 9654717 9703553 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01003381001 9654717 9703553 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01003381001 9654717 9703553 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01003381001 9654717 9703553 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01017553001 10484396 10500558 GSVIVG01025145001 3985627 3998497 GSVIVG01019612001 1944048 1946224 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019612001 1944048 1946224 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019612001 1944048 1946224 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019612001 1944048 1946224 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019612001 1944048 1946224 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019612001 1944048 1946224 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019612001 1944048 1946224 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01019612001 1944048 1946224 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01019612001 1944048 1946224 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01019612001 1944048 1946224 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01019612001 1944048 1946224 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01019612001 1944048 1946224 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024886001 6230644 6240379 GSVIVG01033259001 22092777 22095173 GSVIVG01036304001 3572464 3579471 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01036304001 3572464 3579471 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01036304001 3572464 3579471 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01036304001 3572464 3579471 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01036304001 3572464 3579471 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01036304001 3572464 3579471 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01036304001 3572464 3579471 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01036304001 3572464 3579471 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01036304001 3572464 3579471 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036304001 3572464 3579471 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036304001 3572464 3579471 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036304001 3572464 3579471 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036304001 3572464 3579471 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036304001 3572464 3579471 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036304001 3572464 3579471 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036304001 3572464 3579471 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036304001 3572464 3579471 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01036304001 3572464 3579471 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01036304001 3572464 3579471 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01036304001 3572464 3579471 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01018574001 13169033 13189943 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01018574001 13169033 13189943 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01018574001 13169033 13189943 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01018574001 13169033 13189943 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031181001 1430436 1437353 GSVIVG01020351001 20924263 20926414 GSVIVG01007762001 9308908 9314007 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01007762001 9308908 9314007 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01007762001 9308908 9314007 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01007762001 9308908 9314007 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021166001 2105012 2111101 GSVIVG01030180001 10787096 10796852 GSVIVG01002096001 32909163 32912712 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01004351001 38206841 38211633 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01004351001 38206841 38211633 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01016972001 3075718 3079112 The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01030415001 5400672 5408614 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01005821001 22117052 22119297 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01005821001 22117052 22119297 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01005821001 22117052 22119297 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01005821001 22117052 22119297 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01005821001 22117052 22119297 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01005821001 22117052 22119297 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01005821001 22117052 22119297 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any transcription regulator activity required for initiation or upregulation of transcription. IEA GO:0016563 transcription activator activity GSVIVG01005821001 22117052 22119297 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any transcription regulator activity required for initiation or upregulation of transcription. IEA GO:0016563 transcription activator activity GSVIVG01005821001 22117052 22119297 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any transcription regulator activity required for initiation or upregulation of transcription. IEA GO:0016563 transcription activator activity GSVIVG01005821001 22117052 22119297 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01005821001 22117052 22119297 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01005821001 22117052 22119297 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01005821001 22117052 22119297 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01005821001 22117052 22119297 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01005821001 22117052 22119297 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01014269001 2189219 2190591 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01016964001 3014279 3015341 GSVIVG01033021001 25118471 25119740 GSVIVG01027919001 9421142 9424813 GO:0006396 RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01030640001 7357660 7361079 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. IEA GO:0030528 transcription regulator activity GSVIVG01019298001 1716273 1752185 GSVIVG01020595001 3955218 3957441 GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA GSVIVG01021824001 6899290 6907844 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01021824001 6899290 6907844 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01021824001 6899290 6907844 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01021824001 6899290 6907844 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01031123001 1964482 1965627 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01031123001 1964482 1965627 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01031123001 1964482 1965627 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025294001 2374862 2382923 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025294001 2374862 2382923 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01020115001 10197874 10200282 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025611001 13605025 13606548 GSVIVG01002947001 37314034 37315462 GSVIVG01017205001 5372963 5400525 GSVIVG01015575001 5121267 5122148 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035513001 1910096 1911341 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA Catalysis of the reaction: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA. IEA GO:0004045 aminoacyl-tRNA hydrolase activity GSVIVG01035513001 1910096 1911341 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA Catalysis of the reaction: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA. IEA GO:0004045 aminoacyl-tRNA hydrolase activity GSVIVG01035513001 1910096 1911341 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. IEA GO:0004725 protein tyrosine phosphatase activity GSVIVG01035513001 1910096 1911341 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. IEA GO:0004725 protein tyrosine phosphatase activity GSVIVG01020107001 10280341 10281165 GSVIVG01032523001 28069279 28071952 GSVIVG01030093001 9762881 9768490 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01036658001 19930382 19931178 GSVIVG01013776001 7699113 7701565 GO:0006351 transcription, DNA-dependent The cellular synthesis of RNA on a template of DNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01013776001 7699113 7701565 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01013776001 7699113 7701565 GO:0006351 transcription, DNA-dependent The cellular synthesis of RNA on a template of DNA. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01013776001 7699113 7701565 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01013776001 7699113 7701565 GO:0006351 transcription, DNA-dependent The cellular synthesis of RNA on a template of DNA. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01013776001 7699113 7701565 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01000236001 20319860 20326362 GSVIVG01021688001 9560171 9580056 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. IEA GO:0016836 hydro-lyase activity GSVIVG01018914001 18692507 18692990 GSVIVG01028457001 7895361 7897926 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028457001 7895361 7897926 Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01025833001 11398555 11422512 GO:0043687 post-translational protein modification The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01025833001 11398555 11422512 GO:0051246 regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein. IEA Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. IEA GO:0019787 small conjugating protein ligase activity GSVIVG01009247001 6643141 6643646 GSVIVG01025912001 27308720 27312220 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA GSVIVG01003934001 8086014 8093471 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain. IEA GO:0004177 aminopeptidase activity GSVIVG01003934001 8086014 8093471 GO:0009987 cellular process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. IEA Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain. IEA GO:0004177 aminopeptidase activity GSVIVG01003934001 8086014 8093471 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008235 metalloexopeptidase activity GSVIVG01003934001 8086014 8093471 GO:0009987 cellular process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. IEA GO:0008235 metalloexopeptidase activity GSVIVG01006076001 41139553 41141631 GSVIVG01035831001 4733295 4743951 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01003423001 14869811 14873093 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01003423001 14869811 14873093 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01003423001 14869811 14873093 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01003278001 14025102 14037495 GSVIVG01016333001 4909947 4938957 GSVIVG01033094001 25666700 25670840 GO:0045040 protein import into mitochondrial outer membrane The import of proteins into the outer membrane of the mitochondrion. Outer membrane proteins have a short matrix-targeting sequence followed by a long stretch of hydrophobic amino acids at the N-terminus. The hydrophobic sequence functions as a stop-transfer sequence that both prevents transfer of the protein into the matrix and anchors it as an integral protein in the outer membrane. IEA GO:0005742 mitochondrial outer membrane translocase complex A large complex of the mitochondrial outer membrane that mediates transport of proteins into all mitochondrial compartments. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033094001 25666700 25670840 GO:0045040 protein import into mitochondrial outer membrane The import of proteins into the outer membrane of the mitochondrion. Outer membrane proteins have a short matrix-targeting sequence followed by a long stretch of hydrophobic amino acids at the N-terminus. The hydrophobic sequence functions as a stop-transfer sequence that both prevents transfer of the protein into the matrix and anchors it as an integral protein in the outer membrane. IEA GO:0005742 mitochondrial outer membrane translocase complex A large complex of the mitochondrial outer membrane that mediates transport of proteins into all mitochondrial compartments. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01026648001 20752323 20765631 GO:0043087 regulation of GTPase activity Any process that modulates the rate of GTP hydrolysis by a GTPase. IEA GSVIVG01025067001 4803433 4808810 GSVIVG01001841001 26235618 26238687 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01014713001 8915466 8922437 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01014713001 8915466 8922437 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. IEA GO:0003899 DNA-directed RNA polymerase activity GSVIVG01014713001 8915466 8922437 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01005201001 19131501 19133681 GSVIVG01027840001 8510749 8520878 GSVIVG01027663001 14532193 14533601 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01007996001 6820943 6822833 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01007996001 6820943 6822833 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01007996001 6820943 6822833 GO:0015995 chlorophyll biosynthetic process The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01007996001 6820943 6822833 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the formation of phytyl moiety from the stepwise reduction of a geranylgeranyl moiety. IEA GO:0045550 geranylgeranyl reductase activity GSVIVG01007996001 6820943 6822833 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA Catalysis of the formation of phytyl moiety from the stepwise reduction of a geranylgeranyl moiety. IEA GO:0045550 geranylgeranyl reductase activity GSVIVG01007996001 6820943 6822833 GO:0015995 chlorophyll biosynthetic process The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors. IEA Catalysis of the formation of phytyl moiety from the stepwise reduction of a geranylgeranyl moiety. IEA GO:0045550 geranylgeranyl reductase activity GSVIVG01024918001 6037406 6048305 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01024918001 6037406 6048305 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01024684001 7771748 7774652 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01024684001 7771748 7774652 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01024684001 7771748 7774652 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01024684001 7771748 7774652 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01005274001 20132648 20132896 GSVIVG01031887001 5183321 5191752 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01031887001 5183321 5191752 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01031887001 5183321 5191752 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01031887001 5183321 5191752 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01036028001 7520542 7521754 GSVIVG01032576001 28495602 28498027 GSVIVG01028354001 6501704 6504748 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01024513001 9416225 9417561 GSVIVG01012449001 966610 968738 GSVIVG01009359001 7732525 7734308 GSVIVG01013156001 7426478 7428895 GSVIVG01010264001 18582983 18583441 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01010264001 18582983 18583441 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01037865001 6987237 6990594 GSVIVG01013735001 8079675 8080776 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01014003001 8753713 8773516 GO:0007205 activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway The initiation of the activity of the inactive enzyme protein kinase C as the result of a series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol 3-phosphate. IEA GO:0004143 diacylglycerol kinase activity GSVIVG01034671001 7451177 7452522 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: 3-alpha(S)-strictosidine = tryptamine + secologanin. IEA GO:0016844 strictosidine synthase activity GSVIVG01001437001 20980100 20988849 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01001437001 20980100 20988849 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01021504001 6324940 6326017 GSVIVG01036531001 23106519 23115037 GSVIVG01012431001 712057 713132 GSVIVG01027488001 16362838 16399984 GSVIVG01015264001 2192998 2194487 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019883001 4197374 4209047 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01019883001 4197374 4209047 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01037431001 13866642 13870800 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01037431001 13866642 13870800 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01037431001 13866642 13870800 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01037431001 13866642 13870800 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01005235001 19704943 19705456 GSVIVG01012004001 2273539 2280301 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012004001 2273539 2280301 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01012004001 2273539 2280301 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01019840001 3796865 3797720 GSVIVG01021226001 2743978 2747780 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: cysteamine + O2 = hypotaurine. IEA GO:0047800 cysteamine dioxygenase activity GSVIVG01000055001 3117470 3125237 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01000055001 3117470 3125237 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01000055001 3117470 3125237 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01000055001 3117470 3125237 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000055001 3117470 3125237 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027135001 17550012 17556470 GSVIVG01026140001 12799297 12802450 GSVIVG01017771001 3339230 3340547 GSVIVG01033761001 18045790 18051487 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01033761001 18045790 18051487 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01033761001 18045790 18051487 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01033761001 18045790 18051487 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01018494001 14303099 14307218 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01018494001 14303099 14307218 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). IEA GO:0016769 transferase activity, transferring nitrogenous groups GSVIVG01018494001 14303099 14307218 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + methylthioadenosine. IEA GO:0016847 1-aminocyclopropane-1-carboxylate synthase activity GSVIVG01018494001 14303099 14307218 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01010589001 16276498 16278436 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010589001 16276498 16278436 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010589001 16276498 16278436 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010589001 16276498 16278436 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010589001 16276498 16278436 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010589001 16276498 16278436 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01010589001 16276498 16278436 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01010589001 16276498 16278436 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01010589001 16276498 16278436 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01010589001 16276498 16278436 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01010589001 16276498 16278436 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01010589001 16276498 16278436 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01010589001 16276498 16278436 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01010589001 16276498 16278436 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01010589001 16276498 16278436 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01010589001 16276498 16278436 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01010589001 16276498 16278436 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01010589001 16276498 16278436 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01010589001 16276498 16278436 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01010589001 16276498 16278436 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01010589001 16276498 16278436 GO:0006950 response to stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: 3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + 3,4',5-trihydroxy-stilbene + 4 CO2. IEA GO:0050350 trihydroxystilbene synthase activity GSVIVG01010589001 16276498 16278436 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: 3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + 3,4',5-trihydroxy-stilbene + 4 CO2. IEA GO:0050350 trihydroxystilbene synthase activity GSVIVG01010589001 16276498 16278436 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: 3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + 3,4',5-trihydroxy-stilbene + 4 CO2. IEA GO:0050350 trihydroxystilbene synthase activity GSVIVG01010589001 16276498 16278436 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: 3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + 3,4',5-trihydroxy-stilbene + 4 CO2. IEA GO:0050350 trihydroxystilbene synthase activity GSVIVG01010589001 16276498 16278436 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: 3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + 3,4',5-trihydroxy-stilbene + 4 CO2. IEA GO:0050350 trihydroxystilbene synthase activity GSVIVG01020927001 16999343 16999891 GSVIVG01020672001 3206379 3207234 GSVIVG01034734001 8598335 8605944 GSVIVG01018158001 13775360 13783657 GSVIVG01029706001 13437096 13438487 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01010581001 16386013 16387002 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010581001 16386013 16387002 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010581001 16386013 16387002 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010581001 16386013 16387002 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01010581001 16386013 16387002 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01010581001 16386013 16387002 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01010581001 16386013 16387002 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01010581001 16386013 16387002 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01010581001 16386013 16387002 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01010581001 16386013 16387002 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01010581001 16386013 16387002 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01010581001 16386013 16387002 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01021877001 6099276 6110818 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021877001 6099276 6110818 GO:0006535 cysteine biosynthetic process from serine The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021877001 6099276 6110818 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021877001 6099276 6110818 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: O3-acetyl-L-serine + H2S = L-cysteine + acetate. IEA GO:0004124 cysteine synthase activity GSVIVG01021877001 6099276 6110818 GO:0006535 cysteine biosynthetic process from serine The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: O3-acetyl-L-serine + H2S = L-cysteine + acetate. IEA GO:0004124 cysteine synthase activity GSVIVG01021877001 6099276 6110818 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: O3-acetyl-L-serine + H2S = L-cysteine + acetate. IEA GO:0004124 cysteine synthase activity GSVIVG01021877001 6099276 6110818 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01021877001 6099276 6110818 GO:0006535 cysteine biosynthetic process from serine The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01021877001 6099276 6110818 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01021877001 6099276 6110818 GO:0006520 cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01021877001 6099276 6110818 GO:0006535 cysteine biosynthetic process from serine The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01021877001 6099276 6110818 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01033302001 21677949 21679263 GSVIVG01010078001 14954685 14959548 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01010078001 14954685 14959548 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01010078001 14954685 14959548 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01010078001 14954685 14959548 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01010078001 14954685 14959548 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013916001 6705921 6706748 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01013916001 6705921 6706748 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01033843001 17298621 17301373 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. IEA GO:0008080 N-acetyltransferase activity GSVIVG01024624001 8290025 8295109 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01024624001 8290025 8295109 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01027673001 14478040 14483675 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027673001 14478040 14483675 GO:0009073 aromatic amino acid family biosynthetic process The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01027673001 14478040 14483675 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the reaction: phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. IEA GO:0003866 3-phosphoshikimate 1-carboxyvinyltransferase activity GSVIVG01027673001 14478040 14483675 GO:0009073 aromatic amino acid family biosynthetic process The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). IEA Catalysis of the reaction: phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. IEA GO:0003866 3-phosphoshikimate 1-carboxyvinyltransferase activity GSVIVG01027673001 14478040 14483675 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01027673001 14478040 14483675 GO:0009073 aromatic amino acid family biosynthetic process The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01027673001 14478040 14483675 GO:0008652 cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. IEA Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor). IEA GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups GSVIVG01027673001 14478040 14483675 GO:0009073 aromatic amino acid family biosynthetic process The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). IEA Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor). IEA GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups GSVIVG01000023001 2879218 2884606 GSVIVG01001200001 850530 852426 GSVIVG01003749001 12349750 12353710 GSVIVG01025295001 2363605 2366652 GSVIVG01016910001 2462006 2473398 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01016910001 2462006 2473398 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01016910001 2462006 2473398 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01016910001 2462006 2473398 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016910001 2462006 2473398 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01004781001 16072554 16078027 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01007803001 8873382 8880106 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01007803001 8873382 8880106 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01007803001 8873382 8880106 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007803001 8873382 8880106 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007803001 8873382 8880106 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01007803001 8873382 8880106 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01007803001 8873382 8880106 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01007803001 8873382 8880106 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01007803001 8873382 8880106 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0008236 serine-type peptidase activity GSVIVG01007803001 8873382 8880106 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0008236 serine-type peptidase activity GSVIVG01031759001 4095878 4121942 GSVIVG01028670001 11917907 11921280 GSVIVG01014612001 5712426 5716609 GSVIVG01015972001 16534323 16536895 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01007965001 7101163 7108526 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01007965001 7101163 7108526 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell. IEA GO:0000156 two-component response regulator activity GSVIVG01017611001 1976784 1988796 GSVIVG01035037001 1075445 1078705 GSVIVG01032232001 13477774 13485357 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01032232001 13477774 13485357 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01032232001 13477774 13485357 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01032232001 13477774 13485357 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01017588001 11038350 11044026 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01017588001 11038350 11044026 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01017588001 11038350 11044026 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01017588001 11038350 11044026 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01017588001 11038350 11044026 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01017588001 11038350 11044026 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01021114001 1588546 1593162 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01021114001 1588546 1593162 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01021114001 1588546 1593162 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01021114001 1588546 1593162 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01007962001 7129219 7130944 GSVIVG01012201001 590869 593407 GSVIVG01032162001 21968451 21981294 GSVIVG01008114001 5669941 5674487 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01008114001 5669941 5674487 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01014545001 5016070 5018397 GSVIVG01036700001 23630851 23634422 GSVIVG01028211001 4654964 4661749 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01028211001 4654964 4661749 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01027594001 15209498 15224361 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GSVIVG01032442001 27443804 27454851 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01032442001 27443804 27454851 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01032442001 27443804 27454851 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01032442001 27443804 27454851 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032442001 27443804 27454851 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01010550001 16727563 16729262 GSVIVG01024836001 6525678 6527813 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01029392001 16114328 16117505 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01028422001 7410944 7413951 GSVIVG01009897001 12223870 12228184 GSVIVG01036908001 17792452 17808739 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01036908001 17792452 17808739 Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. IEA GO:0005089 Rho guanyl-nucleotide exchange factor activity GSVIVG01036908001 17792452 17808739 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01032126001 22419088 22425967 GSVIVG01007999001 6795549 6797879 GSVIVG01031584001 18470725 18474810 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01010580001 16405205 16406608 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010580001 16405205 16406608 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010580001 16405205 16406608 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01010580001 16405205 16406608 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01010580001 16405205 16406608 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01010580001 16405205 16406608 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01010580001 16405205 16406608 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01010580001 16405205 16406608 GO:0008610 lipid biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01010580001 16405205 16406608 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01021398001 4909825 4919535 GSVIVG01028502001 8603015 8603741 GSVIVG01001806001 25970478 25980180 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01001806001 25970478 25980180 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001806001 25970478 25980180 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: ATP + D-ribulose 5-phosphate = ADP + D-ribulose 1,5-bisphosphate. IEA GO:0008974 phosphoribulokinase activity GSVIVG01001806001 25970478 25980180 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01001806001 25970478 25980180 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01026971001 18921340 18935679 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01018865001 19132072 19133694 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01018865001 19132072 19133694 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. IEA GO:0004601 peroxidase activity GSVIVG01018865001 19132072 19133694 GO:0006979 response to oxidative stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01018865001 19132072 19133694 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01021445001 5451220 5456608 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01021445001 5451220 5456608 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01021445001 5451220 5456608 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01021445001 5451220 5456608 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01021445001 5451220 5456608 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01021445001 5451220 5456608 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01033170001 8890608 8897634 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01033170001 8890608 8897634 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01033170001 8890608 8897634 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01033170001 8890608 8897634 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01033170001 8890608 8897634 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01033170001 8890608 8897634 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01013535001 2494432 2508192 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013535001 2494432 2508192 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01013535001 2494432 2508192 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01013535001 2494432 2508192 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019623001 2029175 2029598 GSVIVG01031890001 5200765 5204004 GSVIVG01028762001 19119206 19119992 GSVIVG01007594001 11508741 11511764 GSVIVG01036627001 19373924 19378801 GSVIVG01034677001 7508502 7525984 GO:0006090 pyruvate metabolic process The chemical reactions and pathways involving pyruvate, 2-oxopropanoate. IEA GO:0045254 pyruvate dehydrogenase complex Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). IEA Catalysis of the reaction: acetyl-CoA + dihydrolipoamide = CoA + S-acetyldihydrolipoamide. IEA GO:0004742 dihydrolipoyllysine-residue acetyltransferase activity GSVIVG01034677001 7508502 7525984 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0045254 pyruvate dehydrogenase complex Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). IEA Catalysis of the reaction: acetyl-CoA + dihydrolipoamide = CoA + S-acetyldihydrolipoamide. IEA GO:0004742 dihydrolipoyllysine-residue acetyltransferase activity GSVIVG01034677001 7508502 7525984 GO:0006090 pyruvate metabolic process The chemical reactions and pathways involving pyruvate, 2-oxopropanoate. IEA GO:0045254 pyruvate dehydrogenase complex Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01034677001 7508502 7525984 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0045254 pyruvate dehydrogenase complex Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01034677001 7508502 7525984 GO:0006090 pyruvate metabolic process The chemical reactions and pathways involving pyruvate, 2-oxopropanoate. IEA GO:0045254 pyruvate dehydrogenase complex Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01034677001 7508502 7525984 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0045254 pyruvate dehydrogenase complex Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). IEA Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. IEA GO:0008415 acyltransferase activity GSVIVG01032164001 21926405 21932280 GSVIVG01025605001 13661484 13667429 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01025605001 13661484 13667429 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01025605001 13661484 13667429 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01025605001 13661484 13667429 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016888001 2277241 2298366 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin. IEA GO:0004221 ubiquitin thiolesterase activity GSVIVG01036345001 4019713 4021711 Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01036345001 4019713 4021711 Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01009301001 7098705 7099199 GSVIVG01020406001 19951146 19968808 GO:0007067 mitosis A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell. IEA GSVIVG01024369001 1700988 1702092 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GSVIVG01024369001 1700988 1702092 GO:0009607 response to biotic stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism. IEA GSVIVG01031750001 4041065 4046927 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01000824001 2572758 2582363 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01000824001 2572758 2582363 Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium. IEA GO:0005544 calcium-dependent phospholipid binding GSVIVG01001157001 1188670 1189132 GSVIVG01028260001 5007756 5011023 GSVIVG01003937001 8147818 8151971 GSVIVG01014527001 4833434 4836507 GSVIVG01026152001 13065877 13074201 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01026152001 13065877 13074201 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01026152001 13065877 13074201 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01026152001 13065877 13074201 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01026152001 13065877 13074201 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026152001 13065877 13074201 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026152001 13065877 13074201 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01026152001 13065877 13074201 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01016897001 2362293 2377876 GSVIVG01019833001 3729208 3733046 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019833001 3729208 3733046 GO:0006012 galactose metabolic process The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019833001 3729208 3733046 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019833001 3729208 3733046 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019833001 3729208 3733046 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019833001 3729208 3733046 GO:0045226 extracellular polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019833001 3729208 3733046 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01019833001 3729208 3733046 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: UDP-glucose = UDP-galactose. IEA GO:0003978 UDP-glucose 4-epimerase activity GSVIVG01019833001 3729208 3733046 GO:0006012 galactose metabolic process The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. IEA Catalysis of the reaction: UDP-glucose = UDP-galactose. IEA GO:0003978 UDP-glucose 4-epimerase activity GSVIVG01019833001 3729208 3733046 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: UDP-glucose = UDP-galactose. IEA GO:0003978 UDP-glucose 4-epimerase activity GSVIVG01019833001 3729208 3733046 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: UDP-glucose = UDP-galactose. IEA GO:0003978 UDP-glucose 4-epimerase activity GSVIVG01019833001 3729208 3733046 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of the reaction: UDP-glucose = UDP-galactose. IEA GO:0003978 UDP-glucose 4-epimerase activity GSVIVG01019833001 3729208 3733046 GO:0045226 extracellular polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. IEA Catalysis of the reaction: UDP-glucose = UDP-galactose. IEA GO:0003978 UDP-glucose 4-epimerase activity GSVIVG01019833001 3729208 3733046 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: UDP-glucose = UDP-galactose. IEA GO:0003978 UDP-glucose 4-epimerase activity GSVIVG01019833001 3729208 3733046 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019833001 3729208 3733046 GO:0006012 galactose metabolic process The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019833001 3729208 3733046 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019833001 3729208 3733046 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019833001 3729208 3733046 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019833001 3729208 3733046 GO:0045226 extracellular polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019833001 3729208 3733046 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01019833001 3729208 3733046 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + NADPH + H+. IEA GO:0008831 dTDP-4-dehydrorhamnose reductase activity GSVIVG01019833001 3729208 3733046 GO:0006012 galactose metabolic process The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. IEA Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + NADPH + H+. IEA GO:0008831 dTDP-4-dehydrorhamnose reductase activity GSVIVG01019833001 3729208 3733046 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + NADPH + H+. IEA GO:0008831 dTDP-4-dehydrorhamnose reductase activity GSVIVG01019833001 3729208 3733046 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + NADPH + H+. IEA GO:0008831 dTDP-4-dehydrorhamnose reductase activity GSVIVG01019833001 3729208 3733046 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + NADPH + H+. IEA GO:0008831 dTDP-4-dehydrorhamnose reductase activity GSVIVG01019833001 3729208 3733046 GO:0045226 extracellular polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. IEA Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + NADPH + H+. IEA GO:0008831 dTDP-4-dehydrorhamnose reductase activity GSVIVG01019833001 3729208 3733046 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + NADPH + H+. IEA GO:0008831 dTDP-4-dehydrorhamnose reductase activity GSVIVG01019833001 3729208 3733046 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01019833001 3729208 3733046 GO:0006012 galactose metabolic process The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01019833001 3729208 3733046 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01019833001 3729208 3733046 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01019833001 3729208 3733046 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01019833001 3729208 3733046 GO:0045226 extracellular polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01019833001 3729208 3733046 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01019833001 3729208 3733046 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. IEA GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GSVIVG01019833001 3729208 3733046 GO:0006012 galactose metabolic process The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. IEA Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. IEA GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GSVIVG01019833001 3729208 3733046 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. IEA GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GSVIVG01019833001 3729208 3733046 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. IEA GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GSVIVG01019833001 3729208 3733046 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. IEA GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GSVIVG01019833001 3729208 3733046 GO:0045226 extracellular polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. IEA Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. IEA GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GSVIVG01019833001 3729208 3733046 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. IEA GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GSVIVG01019833001 3729208 3733046 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01019833001 3729208 3733046 GO:0006012 galactose metabolic process The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01019833001 3729208 3733046 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01019833001 3729208 3733046 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01019833001 3729208 3733046 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01019833001 3729208 3733046 GO:0045226 extracellular polysaccharide biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01019833001 3729208 3733046 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01007782001 9093027 9096725 GSVIVG01010824001 23048309 23049583 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000472001 8295348 8296724 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01032403001 26978672 27049743 GSVIVG01019086001 16834852 16838222 GSVIVG01028023001 3246671 3258448 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01013547001 20506906 20508157 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020598001 3944619 3945794 GSVIVG01003829001 20478861 20481294 GSVIVG01029647001 20239567 20252628 GSVIVG01008471001 1642887 1656845 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005942 phosphoinositide 3-kinase complex A complex containing a heterodimer of a catalytic subunit and a regulatory (adaptor) subunit of any phosphoinositide 3-kinase (PI3K). IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01008471001 1642887 1656845 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005942 phosphoinositide 3-kinase complex A complex containing a heterodimer of a catalytic subunit and a regulatory (adaptor) subunit of any phosphoinositide 3-kinase (PI3K). IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01008471001 1642887 1656845 GO:0009408 response to heat A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. IEA GO:0005942 phosphoinositide 3-kinase complex A complex containing a heterodimer of a catalytic subunit and a regulatory (adaptor) subunit of any phosphoinositide 3-kinase (PI3K). IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01008471001 1642887 1656845 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005942 phosphoinositide 3-kinase complex A complex containing a heterodimer of a catalytic subunit and a regulatory (adaptor) subunit of any phosphoinositide 3-kinase (PI3K). IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008471001 1642887 1656845 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005942 phosphoinositide 3-kinase complex A complex containing a heterodimer of a catalytic subunit and a regulatory (adaptor) subunit of any phosphoinositide 3-kinase (PI3K). IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008471001 1642887 1656845 GO:0009408 response to heat A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. IEA GO:0005942 phosphoinositide 3-kinase complex A complex containing a heterodimer of a catalytic subunit and a regulatory (adaptor) subunit of any phosphoinositide 3-kinase (PI3K). IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01008471001 1642887 1656845 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005942 phosphoinositide 3-kinase complex A complex containing a heterodimer of a catalytic subunit and a regulatory (adaptor) subunit of any phosphoinositide 3-kinase (PI3K). IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008471001 1642887 1656845 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005942 phosphoinositide 3-kinase complex A complex containing a heterodimer of a catalytic subunit and a regulatory (adaptor) subunit of any phosphoinositide 3-kinase (PI3K). IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008471001 1642887 1656845 GO:0009408 response to heat A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. IEA GO:0005942 phosphoinositide 3-kinase complex A complex containing a heterodimer of a catalytic subunit and a regulatory (adaptor) subunit of any phosphoinositide 3-kinase (PI3K). IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008471001 1642887 1656845 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005942 phosphoinositide 3-kinase complex A complex containing a heterodimer of a catalytic subunit and a regulatory (adaptor) subunit of any phosphoinositide 3-kinase (PI3K). IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01008471001 1642887 1656845 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005942 phosphoinositide 3-kinase complex A complex containing a heterodimer of a catalytic subunit and a regulatory (adaptor) subunit of any phosphoinositide 3-kinase (PI3K). IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01008471001 1642887 1656845 GO:0009408 response to heat A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. IEA GO:0005942 phosphoinositide 3-kinase complex A complex containing a heterodimer of a catalytic subunit and a regulatory (adaptor) subunit of any phosphoinositide 3-kinase (PI3K). IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01008471001 1642887 1656845 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005942 phosphoinositide 3-kinase complex A complex containing a heterodimer of a catalytic subunit and a regulatory (adaptor) subunit of any phosphoinositide 3-kinase (PI3K). IEA Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate. IEA GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GSVIVG01008471001 1642887 1656845 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005942 phosphoinositide 3-kinase complex A complex containing a heterodimer of a catalytic subunit and a regulatory (adaptor) subunit of any phosphoinositide 3-kinase (PI3K). IEA Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate. IEA GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GSVIVG01008471001 1642887 1656845 GO:0009408 response to heat A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. IEA GO:0005942 phosphoinositide 3-kinase complex A complex containing a heterodimer of a catalytic subunit and a regulatory (adaptor) subunit of any phosphoinositide 3-kinase (PI3K). IEA Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate. IEA GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GSVIVG01008471001 1642887 1656845 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA GO:0005942 phosphoinositide 3-kinase complex A complex containing a heterodimer of a catalytic subunit and a regulatory (adaptor) subunit of any phosphoinositide 3-kinase (PI3K). IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01008471001 1642887 1656845 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005942 phosphoinositide 3-kinase complex A complex containing a heterodimer of a catalytic subunit and a regulatory (adaptor) subunit of any phosphoinositide 3-kinase (PI3K). IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01008471001 1642887 1656845 GO:0009408 response to heat A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. IEA GO:0005942 phosphoinositide 3-kinase complex A complex containing a heterodimer of a catalytic subunit and a regulatory (adaptor) subunit of any phosphoinositide 3-kinase (PI3K). IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01006130001 41918358 41918645 GSVIVG01013981001 8405924 8406274 GSVIVG01035639001 2897025 2898371 GSVIVG01024611001 8419739 8428128 GSVIVG01011496001 30039728 30047447 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01011496001 30039728 30047447 GO:0019538 protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01011496001 30039728 30047447 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01011496001 30039728 30047447 GO:0019538 protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01011496001 30039728 30047447 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01011496001 30039728 30047447 GO:0019538 protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01011496001 30039728 30047447 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011496001 30039728 30047447 GO:0019538 protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01011496001 30039728 30047447 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01011496001 30039728 30047447 GO:0019538 protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. IEA GO:0016887 ATPase activity GSVIVG01011496001 30039728 30047447 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01011496001 30039728 30047447 GO:0019538 protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01011610001 6009188 6010229 GSVIVG01009346001 7587611 7588618 GO:0006820 anion transport The directed movement of anions, atoms or small molecules with a net negative charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005741 mitochondrial outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope. IEA Catalysis of the transmembrane transfer of an anion by a voltage-gated channel. An anion is a negatively charged ion. IEA GO:0008308 voltage-gated anion channel activity GSVIVG01009346001 7587611 7588618 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005741 mitochondrial outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope. IEA Catalysis of the transmembrane transfer of an anion by a voltage-gated channel. An anion is a negatively charged ion. IEA GO:0008308 voltage-gated anion channel activity GSVIVG01022414001 19868970 19894729 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022414001 19868970 19894729 Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01030931001 19246673 19248472 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01012354001 998734 999504 GSVIVG01032538001 28172483 28173314 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01036572001 23603520 23606026 GSVIVG01038139001 23788470 23793486 GSVIVG01028934001 17245531 17247214 GSVIVG01011009001 2254171 2256162 GSVIVG01011230001 9870285 9871332 GSVIVG01024158001 694534 700837 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01024158001 694534 700837 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01024158001 694534 700837 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01024158001 694534 700837 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024158001 694534 700837 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024158001 694534 700837 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024158001 694534 700837 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01024158001 694534 700837 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01024158001 694534 700837 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01024158001 694534 700837 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA Catalysis of the reaction: tRNA-uracil + acceptor = tRNA-dihydrouridine + reduced acceptor. IEA GO:0017150 tRNA dihydrouridine synthase activity GSVIVG01024158001 694534 700837 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: tRNA-uracil + acceptor = tRNA-dihydrouridine + reduced acceptor. IEA GO:0017150 tRNA dihydrouridine synthase activity GSVIVG01024158001 694534 700837 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: tRNA-uracil + acceptor = tRNA-dihydrouridine + reduced acceptor. IEA GO:0017150 tRNA dihydrouridine synthase activity GSVIVG01024158001 694534 700837 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01024158001 694534 700837 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01024158001 694534 700837 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01009589001 9692029 9695345 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025435001 812922 814399 GSVIVG01011394001 29303381 29308157 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01011394001 29303381 29308157 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01011394001 29303381 29308157 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01008068001 6090061 6125149 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008068001 6090061 6125149 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008068001 6090061 6125149 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008068001 6090061 6125149 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01008068001 6090061 6125149 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01008068001 6090061 6125149 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01008068001 6090061 6125149 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01008068001 6090061 6125149 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01008068001 6090061 6125149 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008068001 6090061 6125149 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008068001 6090061 6125149 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008068001 6090061 6125149 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01008068001 6090061 6125149 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01008068001 6090061 6125149 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01008068001 6090061 6125149 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01008068001 6090061 6125149 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01008068001 6090061 6125149 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008068001 6090061 6125149 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008068001 6090061 6125149 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008068001 6090061 6125149 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008068001 6090061 6125149 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + methylthioadenosine. IEA GO:0016847 1-aminocyclopropane-1-carboxylate synthase activity GSVIVG01008068001 6090061 6125149 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + methylthioadenosine. IEA GO:0016847 1-aminocyclopropane-1-carboxylate synthase activity GSVIVG01008068001 6090061 6125149 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + methylthioadenosine. IEA GO:0016847 1-aminocyclopropane-1-carboxylate synthase activity GSVIVG01008068001 6090061 6125149 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + methylthioadenosine. IEA GO:0016847 1-aminocyclopropane-1-carboxylate synthase activity GSVIVG01000289001 2365748 2374087 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01000289001 2365748 2374087 Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium. IEA GO:0005544 calcium-dependent phospholipid binding GSVIVG01028425001 7436492 7437685 GSVIVG01013206001 6711943 6739053 GSVIVG01034172001 14640135 14646012 GO:0006626 protein targeting to mitochondrion The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein. IEA GO:0042719 mitochondrial intermembrane space protein transporter complex Soluble complex of the mitochondrial intermembrane space composed of various combinations of small Tim proteins; acts as a protein transporter to guide proteins to the Tim22 complex for insertion into the mitochondrial inner membrane. IEA GSVIVG01034172001 14640135 14646012 GO:0045039 protein import into mitochondrial inner membrane The import of proteins into the mitochondria inner membrane. Inner membrane proteins are first imported into the matrix space where the matrix-targeting sequence is removed; how these proteins then are incorporated into the inner membrane is not known. IEA GO:0042719 mitochondrial intermembrane space protein transporter complex Soluble complex of the mitochondrial intermembrane space composed of various combinations of small Tim proteins; acts as a protein transporter to guide proteins to the Tim22 complex for insertion into the mitochondrial inner membrane. IEA GSVIVG01026044001 25344562 25344903 GSVIVG01013489001 1608314 1670232 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0009341 beta-galactosidase complex A multimeric enzyme complex that in E. coli is a heterooctamer made up of four alpha subunits and four beta subunits. Catalyzes the hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01013489001 1608314 1670232 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0009341 beta-galactosidase complex A multimeric enzyme complex that in E. coli is a heterooctamer made up of four alpha subunits and four beta subunits. Catalyzes the hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01013489001 1608314 1670232 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0009341 beta-galactosidase complex A multimeric enzyme complex that in E. coli is a heterooctamer made up of four alpha subunits and four beta subunits. Catalyzes the hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides. IEA Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides. IEA GO:0004565 beta-galactosidase activity GSVIVG01013489001 1608314 1670232 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0009341 beta-galactosidase complex A multimeric enzyme complex that in E. coli is a heterooctamer made up of four alpha subunits and four beta subunits. Catalyzes the hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides. IEA Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y. IEA GO:0030246 carbohydrate binding GSVIVG01013489001 1608314 1670232 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0009341 beta-galactosidase complex A multimeric enzyme complex that in E. coli is a heterooctamer made up of four alpha subunits and four beta subunits. Catalyzes the hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01038205001 24333171 24336215 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01038666001 21111941 21114958 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01021557001 7046008 7052028 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid. IEA GO:0008378 galactosyltransferase activity GSVIVG01007864001 8207770 8209333 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01029323001 14285204 14293195 GSVIVG01019326001 1093728 1099528 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019326001 1093728 1099528 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019326001 1093728 1099528 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01019326001 1093728 1099528 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01019326001 1093728 1099528 GO:0006352 transcription initiation Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. IEA A sigma factor is the promoter specificity subunit of eubacterial-type multisubunit RNA polymerases, those whose core subunit composition is often described as alpha(2)-beta-beta-prime. (This type of multisubunit RNA polymerase complex is known to be found in eubacteria and plant plastids). Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, this binds specifically to promoter sequences, with the sigma factor making sequence specific contacts with the promoter elements. The sigma subunit is released from the elongating form of the polymerase and is thus free to act catalytically for multiple RNA polymerase core enzymes. IEA GO:0016987 sigma factor activity GSVIVG01019326001 1093728 1099528 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA A sigma factor is the promoter specificity subunit of eubacterial-type multisubunit RNA polymerases, those whose core subunit composition is often described as alpha(2)-beta-beta-prime. (This type of multisubunit RNA polymerase complex is known to be found in eubacteria and plant plastids). Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, this binds specifically to promoter sequences, with the sigma factor making sequence specific contacts with the promoter elements. The sigma subunit is released from the elongating form of the polymerase and is thus free to act catalytically for multiple RNA polymerase core enzymes. IEA GO:0016987 sigma factor activity GSVIVG01017404001 8019852 8048525 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017404001 8019852 8048525 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01032617001 2173408 2189323 GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + H+(out) = sugar(in) + H+(in). IEA GO:0005351 sugar:hydrogen symporter activity GSVIVG01032617001 2173408 2189323 GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: phosphoenolpyruvate + protein L-histidine = pyruvate + protein N(pi)-phospho-L-histidine. IEA GO:0008965 phosphoenolpyruvate-protein phosphotransferase activity GSVIVG01012830001 5869916 5909727 Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum. IEA GO:0003993 acid phosphatase activity GSVIVG01012830001 5869916 5909727 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01012830001 5869916 5909727 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01030375001 5089056 5091618 GO:0009664 plant-type cell wall organization A process that results in the assembly and arrangement of constituent parts of the cellulose and pectin-containing cell wall, or in the disassembly of the cellulose and pectin-containing cell wall. This process is carried out at the cellular level. An example of this process is found in Arabidopsis thaliana. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA GSVIVG01030375001 5089056 5091618 GO:0019953 sexual reproduction The regular alternation, in the life cycle of haplontic, diplontic and diplohaplontic organisms, of meiosis and fertilization which provides for the production offspring. In diplontic organisms there is a life cycle in which the products of meiosis behave directly as gametes, fusing to form a zygote from which the diploid, or sexually reproductive polyploid, adult organism will develop. In diplohaplontic organisms a haploid phase (gametophyte) exists in the life cycle between meiosis and fertilization (e.g. higher plants, many algae and Fungi); the products of meiosis are spores that develop as haploid individuals from which haploid gametes develop to form a diploid zygote; diplohaplontic organisms show an alternation of haploid and diploid generations. In haplontic organisms meiosis occurs in the zygote, giving rise to four haploid cells (e.g. many algae and protozoa), only the zygote is diploid and this may form a resistant spore, tiding organisms over hard times. IEA GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. IEA GSVIVG01003894001 13232903 13233928 GSVIVG01028006001 3136475 3145962 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028006001 3136475 3145962 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01028006001 3136475 3145962 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01001519001 5478597 5480329 GSVIVG01000208001 16103318 16104548 GSVIVG01021024001 15132755 15137711 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01021024001 15132755 15137711 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01003438001 15050327 15058585 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01003438001 15050327 15058585 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01003438001 15050327 15058585 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01012332001 261760 266402 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01012332001 261760 266402 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with copper (Cu) ions. IEA GO:0005507 copper ion binding GSVIVG01012332001 261760 266402 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01012332001 261760 266402 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O. IEA GO:0008471 laccase activity GSVIVG01012332001 261760 266402 GO:0046274 lignin catabolic process The chemical reactions and pathways resulting in the breakdown of lignins, a class of polymers of phenylpropanoid units. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01012332001 261760 266402 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01018697001 10998277 10998575 GSVIVG01012540001 961352 965723 GO:0006541 glutamine metabolic process The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01012540001 961352 965723 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01011768001 4329970 4331667 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01010999001 2323720 2329153 GSVIVG01015201001 1791556 1793477 GSVIVG01014848001 10530106 10530525 GSVIVG01011821001 3849137 3854446 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01024414001 2254437 2266787 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. IEA GO:0008137 NADH dehydrogenase (ubiquinone) activity GSVIVG01024414001 2254437 2266787 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01015563001 4949774 4954868 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015563001 4949774 4954868 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01015563001 4949774 4954868 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01023879001 2757523 2758963 GSVIVG01038720001 20619365 20622755 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01038720001 20619365 20622755 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01038720001 20619365 20622755 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01038720001 20619365 20622755 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038207001 24357327 24358908 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01008575001 759890 762017 GSVIVG01023342001 19551338 19554145 GSVIVG01011643001 5650814 5659360 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01001817001 26059393 26065610 GSVIVG01028899001 17690132 17699354 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028899001 17690132 17699354 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028899001 17690132 17699354 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028899001 17690132 17699354 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028899001 17690132 17699354 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028899001 17690132 17699354 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028899001 17690132 17699354 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01028899001 17690132 17699354 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01028899001 17690132 17699354 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01028899001 17690132 17699354 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01028899001 17690132 17699354 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01028899001 17690132 17699354 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01009984001 13073665 13087048 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01009984001 13073665 13087048 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01009984001 13073665 13087048 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity. IEA GO:0004721 phosphoprotein phosphatase activity GSVIVG01009984001 13073665 13087048 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. IEA GO:0004722 protein serine/threonine phosphatase activity GSVIVG01009984001 13073665 13087048 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01009984001 13073665 13087048 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01019491001 1063753 1066521 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01019491001 1063753 1066521 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01019491001 1063753 1066521 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01019491001 1063753 1066521 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010110001 15680856 15684455 GSVIVG01032215001 21440904 21449200 GSVIVG01029333001 14509292 14517801 GSVIVG01012010001 2225930 2235300 GSVIVG01004959001 17058160 17069261 GSVIVG01029005001 10572519 10577689 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01029005001 10572519 10577689 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01029005001 10572519 10577689 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029005001 10572519 10577689 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01029005001 10572519 10577689 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029005001 10572519 10577689 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01029005001 10572519 10577689 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01029005001 10572519 10577689 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01029005001 10572519 10577689 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01029005001 10572519 10577689 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01026055001 25246446 25247384 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01012707001 859076 859327 GSVIVG01007277001 31214437 31218997 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01007277001 31214437 31218997 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01007277001 31214437 31218997 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038567001 21804595 21808723 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01038567001 21804595 21808723 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain. IEA GO:0004177 aminopeptidase activity GSVIVG01022413001 19855520 19861400 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid. IEA GO:0008378 galactosyltransferase activity GSVIVG01037071001 8195668 8197771 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004185 serine-type carboxypeptidase activity GSVIVG01035613001 2718501 2727390 GSVIVG01029851001 409663 410043 GSVIVG01036674001 20100484 20105071 GSVIVG01028074001 3625404 3628205 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01028074001 3625404 3628205 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01028074001 3625404 3628205 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005694 chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01009948001 12725144 12753122 GSVIVG01015446001 3768892 3770348 GO:0006596 polyamine biosynthetic process The chemical reactions and pathways resulting in the formation of polyamines, any organic compound containing two or more amino groups. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015446001 3768892 3770348 GO:0006596 polyamine biosynthetic process The chemical reactions and pathways resulting in the formation of polyamines, any organic compound containing two or more amino groups. IEA Catalysis of the reaction: L-ornithine = putrescine + CO2. IEA GO:0004586 ornithine decarboxylase activity GSVIVG01015446001 3768892 3770348 GO:0006596 polyamine biosynthetic process The chemical reactions and pathways resulting in the formation of polyamines, any organic compound containing two or more amino groups. IEA Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. IEA GO:0016829 lyase activity GSVIVG01015446001 3768892 3770348 GO:0006596 polyamine biosynthetic process The chemical reactions and pathways resulting in the formation of polyamines, any organic compound containing two or more amino groups. IEA Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. IEA GO:0016831 carboxy-lyase activity GSVIVG01022427001 20084792 20090820 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01022427001 20084792 20090820 GO:0006970 response to osmotic stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01022427001 20084792 20090820 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01022427001 20084792 20090820 GO:0006970 response to osmotic stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01022427001 20084792 20090820 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01022427001 20084792 20090820 GO:0006970 response to osmotic stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01022427001 20084792 20090820 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01022427001 20084792 20090820 GO:0006970 response to osmotic stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01030860001 17872987 17873220 GSVIVG01015695001 15758793 15760182 GO:0007205 activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway The initiation of the activity of the inactive enzyme protein kinase C as the result of a series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol 3-phosphate. IEA GO:0004143 diacylglycerol kinase activity GSVIVG01024140001 854295 855373 GSVIVG01030930001 19228765 19229744 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01025570001 13982946 13986633 GSVIVG01019160001 15919428 15925004 GSVIVG01022249001 17820702 17829503 GSVIVG01014523001 4797274 4799404 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014523001 4797274 4799404 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014523001 4797274 4799404 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014523001 4797274 4799404 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000178001 15918217 15920103 GSVIVG01032470001 27725836 27731573 GO:0009435 NAD biosynthetic process The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: L-aspartate + O2 = iminosuccinate + H2O2. IEA GO:0008734 L-aspartate oxidase activity GSVIVG01032470001 27725836 27731573 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: L-aspartate + O2 = iminosuccinate + H2O2. IEA GO:0008734 L-aspartate oxidase activity GSVIVG01032470001 27725836 27731573 GO:0009435 NAD biosynthetic process The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01032470001 27725836 27731573 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01032470001 27725836 27731573 GO:0009435 NAD biosynthetic process The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01032470001 27725836 27731573 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01012561001 3626367 3636179 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01012561001 3626367 3636179 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01001058001 7179228 7181141 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001058001 7179228 7181141 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001058001 7179228 7181141 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001058001 7179228 7181141 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01001058001 7179228 7181141 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01001058001 7179228 7181141 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01001058001 7179228 7181141 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01001058001 7179228 7181141 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01001058001 7179228 7181141 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. IEA GO:0004568 chitinase activity GSVIVG01001058001 7179228 7181141 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01001058001 7179228 7181141 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01001058001 7179228 7181141 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01001058001 7179228 7181141 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01001058001 7179228 7181141 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01001058001 7179228 7181141 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01001058001 7179228 7181141 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01001058001 7179228 7181141 GO:0006032 chitin catabolic process The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01001058001 7179228 7181141 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01007661001 10749584 10751781 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01007661001 10749584 10751781 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01007661001 10749584 10751781 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01007661001 10749584 10751781 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01007661001 10749584 10751781 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025545001 14147257 14148850 GSVIVG01023643001 8370638 8375427 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023643001 8370638 8375427 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01018775001 20020599 20021567 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids. IEA GO:0004518 nuclease activity GSVIVG01018775001 20020599 20021567 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01030835001 17277976 17282444 GSVIVG01011233001 9914680 9915566 GSVIVG01013243001 6343552 6352827 GSVIVG01027574001 15442749 15448056 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01012874001 6407058 6408557 GSVIVG01026983001 18829538 18832272 GSVIVG01016335001 4853462 4854800 GSVIVG01036408001 4744917 4756346 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01036408001 4744917 4756346 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01036408001 4744917 4756346 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01036408001 4744917 4756346 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01036408001 4744917 4756346 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01036408001 4744917 4756346 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01036408001 4744917 4756346 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01036408001 4744917 4756346 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01036408001 4744917 4756346 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01036408001 4744917 4756346 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds. IEA GO:0004176 ATP-dependent peptidase activity GSVIVG01036408001 4744917 4756346 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01036408001 4744917 4756346 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01036408001 4744917 4756346 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01036408001 4744917 4756346 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01036408001 4744917 4756346 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01036408001 4744917 4756346 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01036408001 4744917 4756346 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01036408001 4744917 4756346 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01036408001 4744917 4756346 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01036408001 4744917 4756346 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. IEA GO:0004888 transmembrane receptor activity GSVIVG01036408001 4744917 4756346 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036408001 4744917 4756346 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036408001 4744917 4756346 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036408001 4744917 4756346 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036408001 4744917 4756346 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036408001 4744917 4756346 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036408001 4744917 4756346 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036408001 4744917 4756346 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036408001 4744917 4756346 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036408001 4744917 4756346 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036408001 4744917 4756346 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01036408001 4744917 4756346 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01036408001 4744917 4756346 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01036408001 4744917 4756346 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01036408001 4744917 4756346 GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. IEA GO:0031224 intrinsic to membrane Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01019692001 2501638 2512150 Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. IEA GO:0008171 O-methyltransferase activity GSVIVG01032407001 27067965 27073752 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01032407001 27067965 27073752 GO:0042765 GPI-anchor transamidase complex An enzyme complex which in humans and yeast consists of at least five proteins; for example, the complex contains GAA1, GPI8, PIG-S, PIG-U, and PIG-T in human, and Gaa1p, Gab1p, Gpi8p, Gpi16p, and Gpi17p in yeast. Catalyzes the posttranslational attachment of the carboxyl-terminus of a precursor protein to a GPI-anchor. IEA GSVIVG01012194001 649077 654363 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: 1,4-alpha-D-glucosyl(n) + phosphate = 1,4-alpha-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate. The name should be qualified in each instance by adding the name of the natural substrate, e.g. maltodextrin phosphorylase, starch phosphorylase, glycogen phosphorylase. IEA GO:0004645 phosphorylase activity GSVIVG01012194001 649077 654363 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01024614001 8395465 8397562 GSVIVG01006764001 28264425 28272940 GSVIVG01032157001 22053523 22055619 Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate. IEA GO:0008146 sulfotransferase activity GSVIVG01010321001 19480171 19484452 GSVIVG01014092001 292203 312996 GO:0005992 trehalose biosynthetic process The chemical reactions and pathways resulting in the formation of trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01014092001 292203 312996 GO:0005992 trehalose biosynthetic process The chemical reactions and pathways resulting in the formation of trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi. IEA Catalysis of the reaction: UDP-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate. IEA GO:0003825 alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity GSVIVG01004939001 21682875 21685163 GSVIVG01038258001 24750436 24753752 GSVIVG01002031001 32400833 32402601 GSVIVG01022918001 18064449 18066807 GSVIVG01031973001 5832904 5834101 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01031973001 5832904 5834101 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01031973001 5832904 5834101 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01036142001 20227595 20229538 GSVIVG01000288001 2354479 2357708 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. IEA GO:0004499 flavin-containing monooxygenase activity GSVIVG01000288001 2354479 2357708 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01000288001 2354479 2357708 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. IEA GO:0050661 NADP or NADPH binding GSVIVG01036991001 9160685 9162450 GSVIVG01036152001 20029454 20031964 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01036152001 20029454 20031964 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01036152001 20029454 20031964 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01036152001 20029454 20031964 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01036152001 20029454 20031964 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01036152001 20029454 20031964 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01038484001 10217207 10217764 GSVIVG01037441001 13684774 13698955 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01038668001 21102338 21105009 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01025107001 4386064 4389065 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01012773001 23472857 23476504 Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01032131001 22365435 22377485 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032131001 22365435 22377485 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01010805001 22819171 22824151 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01010805001 22819171 22824151 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01010805001 22819171 22824151 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01010805001 22819171 22824151 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01010805001 22819171 22824151 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010805001 22819171 22824151 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01010805001 22819171 22824151 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01010805001 22819171 22824151 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01030534001 6545100 6546456 GSVIVG01030373001 5074039 5075368 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. IEA GO:0008080 N-acetyltransferase activity GSVIVG01031931001 5494122 5528939 GO:0046854 phosphoinositide phosphorylation The process of introducing one or more phosphate groups into a phosphoinositide, a class of substances comprising phosphatidylinositol and its derivatives. IEA Catalysis of the phosphorylation of myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol. IEA GO:0004428 inositol or phosphatidylinositol kinase activity GSVIVG01031931001 5494122 5528939 GO:0048015 phosphoinositide-mediated signaling A series of molecular signals in which a cell uses a phosphoinositide to convert an extracellular signal into a response. IEA Catalysis of the phosphorylation of myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol. IEA GO:0004428 inositol or phosphatidylinositol kinase activity GSVIVG01031931001 5494122 5528939 GO:0046854 phosphoinositide phosphorylation The process of introducing one or more phosphate groups into a phosphoinositide, a class of substances comprising phosphatidylinositol and its derivatives. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031931001 5494122 5528939 GO:0048015 phosphoinositide-mediated signaling A series of molecular signals in which a cell uses a phosphoinositide to convert an extracellular signal into a response. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031931001 5494122 5528939 GO:0046854 phosphoinositide phosphorylation The process of introducing one or more phosphate groups into a phosphoinositide, a class of substances comprising phosphatidylinositol and its derivatives. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01031931001 5494122 5528939 GO:0048015 phosphoinositide-mediated signaling A series of molecular signals in which a cell uses a phosphoinositide to convert an extracellular signal into a response. IEA Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). IEA GO:0016773 phosphotransferase activity, alcohol group as acceptor GSVIVG01028149001 4204074 4218769 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01028149001 4204074 4218769 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01028149001 4204074 4218769 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01028149001 4204074 4218769 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014580001 5356452 5357337 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01014580001 5356452 5357337 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01014580001 5356452 5357337 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01014580001 5356452 5357337 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01014580001 5356452 5357337 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01014580001 5356452 5357337 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01038648001 21223312 21223523 GSVIVG01035536001 2104886 2112730 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01035536001 2104886 2112730 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01035536001 2104886 2112730 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01038592001 21629331 21631151 GSVIVG01022684001 14940873 14950807 GSVIVG01013106001 8233865 8234512 GSVIVG01015659001 15118890 15122036 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01001951001 15222550 15238258 Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. IEA GO:0016791 phosphatase activity GSVIVG01022192001 17324619 17330435 GSVIVG01024206001 288653 289862 GSVIVG01009436001 8344102 8349609 GSVIVG01007746001 9618400 9624140 GSVIVG01016168001 7110705 7121507 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01028906001 17659516 17670931 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01011393001 29296594 29300644 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005945 6-phosphofructokinase complex A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known. IEA Catalysis of the reaction: ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate. IEA GO:0003872 6-phosphofructokinase activity GSVIVG01011393001 29296594 29300644 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA GO:0005945 6-phosphofructokinase complex A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037566001 11148009 11148569 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01037566001 11148009 11148569 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01001044001 6913052 6916691 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01001044001 6913052 6916691 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01001044001 6913052 6916691 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01001044001 6913052 6916691 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01001044001 6913052 6916691 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01031476001 18144892 18154263 GSVIVG01031345001 166469 172217 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01031345001 166469 172217 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01031345001 166469 172217 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids. IEA GO:0004518 nuclease activity GSVIVG01031345001 166469 172217 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01025105001 4432854 4436338 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01025105001 4432854 4436338 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01025105001 4432854 4436338 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli. IEA GO:0004707 MAP kinase activity GSVIVG01025105001 4432854 4436338 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01025105001 4432854 4436338 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020145001 9877667 9880443 GO:0016043 cellular component organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cellular component. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01020145001 9877667 9880443 GO:0030036 actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. IEA Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments. IEA GO:0003779 actin binding GSVIVG01003897001 13320308 13321444 GSVIVG01022276001 18093937 18101516 GSVIVG01005288001 20217514 20219705 Interacting selectively and non-covalently with calcium ions (Ca2+). IEA GO:0005509 calcium ion binding GSVIVG01005288001 20217514 20219705 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01005288001 20217514 20219705 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021470001 5887420 5907750 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01021470001 5887420 5907750 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01021470001 5887420 5907750 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01019876001 4139671 4141512 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01019876001 4139671 4141512 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01036434001 5084399 5114656 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01018208001 13226874 13227697 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01036441001 21945085 21953426 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01036441001 21945085 21953426 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01018286001 11882717 11884138 GSVIVG01021545001 6870591 6873990 Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01026355001 14742965 14866094 GSVIVG01020767001 2250006 2250200 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01027551001 15703499 15750982 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01027551001 15703499 15750982 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01027551001 15703499 15750982 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01027551001 15703499 15750982 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01027551001 15703499 15750982 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01027551001 15703499 15750982 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01024641001 8133681 8137013 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01024641001 8133681 8137013 Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity. IEA GO:0004721 phosphoprotein phosphatase activity GSVIVG01029969001 2448879 2473426 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01029969001 2448879 2473426 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with double-stranded RNA. IEA GO:0003725 double-stranded RNA binding GSVIVG01017636001 2181822 2182295 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01036014001 7205148 7207822 GSVIVG01034020001 15791705 15794682 GO:0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). IEA GSVIVG01008914001 3351205 3359027 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01008914001 3351205 3359027 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01026690001 4871046 4871552 GSVIVG01016975001 3105732 3116145 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01016975001 3105732 3116145 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01016975001 3105732 3116145 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01016975001 3105732 3116145 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01016975001 3105732 3116145 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01016975001 3105732 3116145 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01016975001 3105732 3116145 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01016975001 3105732 3116145 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01016975001 3105732 3116145 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01016975001 3105732 3116145 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion. IEA GO:0004806 triglyceride lipase activity GSVIVG01016975001 3105732 3116145 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion. IEA GO:0004806 triglyceride lipase activity GSVIVG01016975001 3105732 3116145 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion. IEA GO:0004806 triglyceride lipase activity GSVIVG01016975001 3105732 3116145 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016975001 3105732 3116145 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01016975001 3105732 3116145 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027512001 16070237 16088384 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01027512001 16070237 16088384 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01027512001 16070237 16088384 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01027512001 16070237 16088384 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01034879001 15792545 15844126 GSVIVG01038662001 21130943 21133170 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01038662001 21130943 21133170 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. IEA GO:0005198 structural molecule activity GSVIVG01038662001 21130943 21133170 GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01038662001 21130943 21133170 GO:0030001 metal ion transport The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0015629 actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01006056001 23597329 23603625 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. IEA GO:0008233 peptidase activity GSVIVG01006248001 24052749 24053597 GSVIVG01013875001 5801761 5806110 GSVIVG01033942001 16505447 16511893 GSVIVG01007923001 7508597 7514311 GSVIVG01010439001 20592975 20594160 GSVIVG01035645001 2939877 2952804 GSVIVG01008564001 845714 847010 Catalysis of the hydrolysis of any ester bond. IEA GO:0016788 hydrolase activity, acting on ester bonds GSVIVG01033023001 25129238 25146285 GSVIVG01021040001 14874065 14903057 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01021040001 14874065 14903057 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01001444001 21065584 21069368 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01001444001 21065584 21069368 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01001444001 21065584 21069368 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01001444001 21065584 21069368 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006063001 40962443 40964857 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01006063001 40962443 40964857 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01006063001 40962443 40964857 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01006063001 40962443 40964857 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01006063001 40962443 40964857 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01006063001 40962443 40964857 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01006063001 40962443 40964857 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other. IEA GO:0005337 nucleoside transmembrane transporter activity GSVIVG01006063001 40962443 40964857 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other. IEA GO:0005337 nucleoside transmembrane transporter activity GSVIVG01006063001 40962443 40964857 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01006063001 40962443 40964857 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01006063001 40962443 40964857 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01006063001 40962443 40964857 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01035166001 12503309 12505207 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01035166001 12503309 12505207 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01035166001 12503309 12505207 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01035166001 12503309 12505207 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01029691001 13123107 13124074 GSVIVG01022167001 17188415 17190300 GSVIVG01006627001 27143477 27146951 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01006627001 27143477 27146951 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01022097001 16552767 16572286 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01035112001 1552748 1558300 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033815001 17555798 17564053 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01033815001 17555798 17564053 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01033815001 17555798 17564053 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033815001 17555798 17564053 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033815001 17555798 17564053 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01033815001 17555798 17564053 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01003478001 10619358 10626534 Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01006395001 25596523 25597369 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01006395001 25596523 25597369 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017430001 8441486 8444128 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: diphosphate + H2O = 2 phosphate. IEA GO:0004427 inorganic diphosphatase activity GSVIVG01017430001 8441486 8444128 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: diphosphate + H2O = 2 phosphate. IEA GO:0004427 inorganic diphosphatase activity GSVIVG01017430001 8441486 8444128 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: diphosphate + H2O = 2 phosphate. IEA GO:0004427 inorganic diphosphatase activity GSVIVG01017430001 8441486 8444128 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: diphosphate + H2O = 2 phosphate. IEA GO:0004427 inorganic diphosphatase activity GSVIVG01017430001 8441486 8444128 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the reaction: diphosphate + H2O = 2 phosphate. IEA GO:0004427 inorganic diphosphatase activity GSVIVG01017430001 8441486 8444128 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the reaction: diphosphate + H2O = 2 phosphate. IEA GO:0004427 inorganic diphosphatase activity GSVIVG01017430001 8441486 8444128 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of pyrophosphate, which generates a proton motive force. IEA GO:0009678 hydrogen-translocating pyrophosphatase activity GSVIVG01017430001 8441486 8444128 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of pyrophosphate, which generates a proton motive force. IEA GO:0009678 hydrogen-translocating pyrophosphatase activity GSVIVG01017430001 8441486 8444128 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of pyrophosphate, which generates a proton motive force. IEA GO:0009678 hydrogen-translocating pyrophosphatase activity GSVIVG01017430001 8441486 8444128 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of pyrophosphate, which generates a proton motive force. IEA GO:0009678 hydrogen-translocating pyrophosphatase activity GSVIVG01017430001 8441486 8444128 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of pyrophosphate, which generates a proton motive force. IEA GO:0009678 hydrogen-translocating pyrophosphatase activity GSVIVG01017430001 8441486 8444128 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of pyrophosphate, which generates a proton motive force. IEA GO:0009678 hydrogen-translocating pyrophosphatase activity GSVIVG01017430001 8441486 8444128 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01017430001 8441486 8444128 GO:0006814 sodium ion transport The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01017430001 8441486 8444128 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01017430001 8441486 8444128 GO:0006885 regulation of pH Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01017430001 8441486 8444128 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01017430001 8441486 8444128 GO:0015992 proton transport The directed movement of protons (hydrogen ions) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). IEA GO:0015385 sodium:hydrogen antiporter activity GSVIVG01037763001 7659804 7663373 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01037763001 7659804 7663373 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01011751001 4557702 4559021 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004185 serine-type carboxypeptidase activity GSVIVG01029940001 1804064 1830796 GSVIVG01024725001 7432652 7435612 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024725001 7432652 7435612 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01033616001 19242067 19246975 GSVIVG01017295001 6445703 6450595 GSVIVG01002442001 34738580 34739133 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01002442001 34738580 34739133 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01015426001 3566479 3569075 GSVIVG01001989001 6105557 6115679 GSVIVG01036939001 17306171 17309205 GSVIVG01019850001 3829799 3832542 GSVIVG01037902001 6511005 6511621 GSVIVG01010324001 19500062 19509471 GSVIVG01035663001 3110422 3117976 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01013386001 803433 805930 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01013386001 803433 805930 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0010181 FMN binding GSVIVG01013386001 803433 805930 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01010491001 21033814 21034911 GSVIVG01001055001 7129352 7130572 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01001055001 7129352 7130572 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01020692001 3072291 3072601 GSVIVG01001461001 21182229 21185913 GO:0009690 cytokinin metabolic process The chemical reactions and pathways involving cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001461001 21182229 21185913 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001461001 21182229 21185913 GO:0009690 cytokinin metabolic process The chemical reactions and pathways involving cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001461001 21182229 21185913 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01001461001 21182229 21185913 GO:0009690 cytokinin metabolic process The chemical reactions and pathways involving cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators. IEA Catalysis of the reaction: N6-dimethylallyladenine + acceptor + H2O = adenine + 3-methylbut-2-enal + reduced electron acceptor. IEA GO:0019139 cytokinin dehydrogenase activity GSVIVG01001461001 21182229 21185913 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: N6-dimethylallyladenine + acceptor + H2O = adenine + 3-methylbut-2-enal + reduced electron acceptor. IEA GO:0019139 cytokinin dehydrogenase activity GSVIVG01001461001 21182229 21185913 GO:0009690 cytokinin metabolic process The chemical reactions and pathways involving cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01001461001 21182229 21185913 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. IEA GO:0050660 FAD binding GSVIVG01037970001 11828308 11830078 GSVIVG01028117001 3928254 3955340 GSVIVG01023071001 15899399 15899924 GSVIVG01037186001 28208996 28216173 GO:0005985 sucrose metabolic process The chemical reactions and pathways involving sucrose, the disaccharide fructofuranosyl-glucopyranoside. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01037186001 28208996 28216173 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01037186001 28208996 28216173 GO:0005985 sucrose metabolic process The chemical reactions and pathways involving sucrose, the disaccharide fructofuranosyl-glucopyranoside. IEA Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01037186001 28208996 28216173 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). IEA GO:0016757 transferase activity, transferring glycosyl groups GSVIVG01037186001 28208996 28216173 GO:0005985 sucrose metabolic process The chemical reactions and pathways involving sucrose, the disaccharide fructofuranosyl-glucopyranoside. IEA Catalysis of the reaction: UDP-glucose + D-fructose 6-phosphate = UDP + sucrose 6-phosphate. IEA GO:0046524 sucrose-phosphate synthase activity GSVIVG01037186001 28208996 28216173 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: UDP-glucose + D-fructose 6-phosphate = UDP + sucrose 6-phosphate. IEA GO:0046524 sucrose-phosphate synthase activity GSVIVG01016267001 5719142 5737969 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the transfer of a phosphate group from one position to another within a single molecule. IEA GO:0016868 intramolecular transferase activity, phosphotransferases GSVIVG01022515001 4253675 4259819 GSVIVG01011177001 7811469 7821315 GSVIVG01009935001 12545223 12566131 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01009935001 12545223 12566131 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01009935001 12545223 12566131 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01009935001 12545223 12566131 Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01001098001 22628856 22634048 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001098001 22628856 22634048 GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001098001 22628856 22634048 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01001098001 22628856 22634048 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate. IEA GO:0004801 transaldolase activity GSVIVG01001098001 22628856 22634048 GO:0006098 pentose-phosphate shunt The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate. IEA GO:0004801 transaldolase activity GSVIVG01001098001 22628856 22634048 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate. IEA GO:0004801 transaldolase activity GSVIVG01015720001 16336055 16343696 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015720001 16336055 16343696 GO:0006012 galactose metabolic process The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015720001 16336055 16343696 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015720001 16336055 16343696 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015720001 16336055 16343696 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015720001 16336055 16343696 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015720001 16336055 16343696 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: UDP-glucose = UDP-galactose. IEA GO:0003978 UDP-glucose 4-epimerase activity GSVIVG01015720001 16336055 16343696 GO:0006012 galactose metabolic process The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. IEA Catalysis of the reaction: UDP-glucose = UDP-galactose. IEA GO:0003978 UDP-glucose 4-epimerase activity GSVIVG01015720001 16336055 16343696 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the reaction: UDP-glucose = UDP-galactose. IEA GO:0003978 UDP-glucose 4-epimerase activity GSVIVG01015720001 16336055 16343696 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: UDP-glucose = UDP-galactose. IEA GO:0003978 UDP-glucose 4-epimerase activity GSVIVG01015720001 16336055 16343696 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the reaction: UDP-glucose = UDP-galactose. IEA GO:0003978 UDP-glucose 4-epimerase activity GSVIVG01015720001 16336055 16343696 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of the reaction: UDP-glucose = UDP-galactose. IEA GO:0003978 UDP-glucose 4-epimerase activity GSVIVG01015720001 16336055 16343696 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01015720001 16336055 16343696 GO:0006012 galactose metabolic process The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01015720001 16336055 16343696 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01015720001 16336055 16343696 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01015720001 16336055 16343696 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01015720001 16336055 16343696 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01015720001 16336055 16343696 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01015720001 16336055 16343696 GO:0006012 galactose metabolic process The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01015720001 16336055 16343696 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01015720001 16336055 16343696 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01015720001 16336055 16343696 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01015720001 16336055 16343696 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of the transfer of cation from one side of the membrane to the other. IEA GO:0008324 cation transmembrane transporter activity GSVIVG01015720001 16336055 16343696 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. IEA GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GSVIVG01015720001 16336055 16343696 GO:0006012 galactose metabolic process The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. IEA Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. IEA GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GSVIVG01015720001 16336055 16343696 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. IEA GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GSVIVG01015720001 16336055 16343696 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. IEA GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GSVIVG01015720001 16336055 16343696 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. IEA GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GSVIVG01015720001 16336055 16343696 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. IEA GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GSVIVG01015720001 16336055 16343696 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01015720001 16336055 16343696 GO:0006012 galactose metabolic process The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01015720001 16336055 16343696 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01015720001 16336055 16343696 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01015720001 16336055 16343696 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01015720001 16336055 16343696 GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. IEA Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. IEA GO:0050662 coenzyme binding GSVIVG01004839001 5557550 5562196 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01004839001 5557550 5562196 GO:0006970 response to osmotic stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01004839001 5557550 5562196 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01004839001 5557550 5562196 GO:0006970 response to osmotic stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01004839001 5557550 5562196 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01004839001 5557550 5562196 GO:0006970 response to osmotic stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01004839001 5557550 5562196 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01004839001 5557550 5562196 GO:0006970 response to osmotic stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01004839001 5557550 5562196 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01004839001 5557550 5562196 GO:0006970 response to osmotic stress A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01015238001 2038926 2046689 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0000159 protein phosphatase type 2A complex A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit. IEA Modulation of the activity of the enzyme protein phosphatase type 2A. IEA GO:0008601 protein phosphatase type 2A regulator activity GSVIVG01033590001 19482655 19484063 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01022737001 15829114 15840502 Interacting selectively and non-covalently with single-stranded DNA. IEA GO:0003697 single-stranded DNA binding GSVIVG01011570001 6411341 6412579 GSVIVG01013783001 7654830 7654874 GSVIVG01014532001 4868316 4870178 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01023298001 19964300 19964488 GSVIVG01011418001 29523628 29527202 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01011418001 29523628 29527202 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01027941001 9803723 9808509 GSVIVG01037248001 16920784 16923780 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032384001 26855643 26857187 GSVIVG01001384001 24125449 24140662 GSVIVG01004878001 16343509 16355422 GSVIVG01013419001 589627 592148 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01033769001 17991839 17993889 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage. IEA GO:0016209 antioxidant activity GSVIVG01033769001 17991839 17993889 GO:0045454 cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01000199001 16055622 16057891 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01000199001 16055622 16057891 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01000199001 16055622 16057891 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01000199001 16055622 16057891 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01020353001 20862597 20865868 GSVIVG01022999001 17123687 17134431 GO:0006629 lipid metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022999001 17123687 17134431 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01022999001 17123687 17134431 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01038612001 21490738 21492403 GSVIVG01034612001 14441176 14444235 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01034612001 14441176 14444235 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. IEA GO:0031072 heat shock protein binding GSVIVG01034612001 14441176 14444235 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01034612001 14441176 14444235 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01015538001 4657020 4659571 GSVIVG01021615001 8112571 8129374 GO:0046836 glycolipid transport The directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Enables the directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of, within or between cells. IEA GO:0017089 glycolipid transporter activity GSVIVG01021615001 8112571 8129374 GO:0046836 glycolipid transport The directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a glycolipid, any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic moiety such as an acylglycerol, a sphingoid, a ceramide (N-acylsphingoid) or a prenyl phosphate. IEA GO:0051861 glycolipid binding GSVIVG01036037001 7669424 7671321 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01001312001 5231388 5241248 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01001312001 5231388 5241248 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01000153001 15698760 15706662 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01000153001 15698760 15706662 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01000153001 15698760 15706662 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. IEA GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GSVIVG01000153001 15698760 15706662 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species. IEA GO:0031418 L-ascorbic acid binding GSVIVG01027951001 9961043 9963031 GSVIVG01009333001 7515408 7516048 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01016165001 7224356 7245255 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01008161001 5190270 5194632 GSVIVG01013784001 7651093 7654777 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01013784001 7651093 7654777 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01013784001 7651093 7654777 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01013784001 7651093 7654777 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01013784001 7651093 7654777 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01013784001 7651093 7654777 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01013784001 7651093 7654777 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01013784001 7651093 7654777 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01019114001 16613622 16615440 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0009538 photosystem I reaction center A photochemical system containing P700, the chlorophyll a dimer that functions as a primary electron donor. Functioning as a light-dependent plastocyanin-ferredoxin oxidoreductase, it transfers electrons from plastocyanin to ferredoxin. IEA GSVIVG01011816001 3875426 3876784 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01011816001 3875426 3876784 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01003451001 10256374 10258115 GSVIVG01031342001 230323 237872 GSVIVG01025565001 14010883 14022824 GO:0032313 regulation of Rab GTPase activity Any process that modulates the activity of a GTPase of the Rab family. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Increases the rate of GTP hydrolysis by a GTPase of the Rab family. IEA GO:0005097 Rab GTPase activator activity GSVIVG01031534001 17417937 17423749 GSVIVG01030327001 8809100 8810536 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01022223001 17631704 17644669 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01022223001 17631704 17644669 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the transfer of a segment of a (1,4)-alpha-D-glucan to a new 4-position in an acceptor, which may be glucose or (1,4)-alpha-D-glucan. IEA GO:0004134 4-alpha-glucanotransferase activity GSVIVG01022223001 17631704 17644669 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge. IEA GO:0043169 cation binding GSVIVG01028200001 4566601 4569752 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028200001 4566601 4569752 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028200001 4566601 4569752 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01028200001 4566601 4569752 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01028200001 4566601 4569752 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01028200001 4566601 4569752 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. IEA GO:0004022 alcohol dehydrogenase (NAD) activity GSVIVG01028200001 4566601 4569752 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028200001 4566601 4569752 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028200001 4566601 4569752 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01028200001 4566601 4569752 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01028200001 4566601 4569752 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01028200001 4566601 4569752 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+. IEA GO:0008667 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity GSVIVG01028200001 4566601 4569752 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01028200001 4566601 4569752 GO:0009239 enterobactin biosynthetic process The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01028200001 4566601 4569752 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01024803001 6832444 6835121 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01024803001 6832444 6835121 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01024803001 6832444 6835121 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01024803001 6832444 6835121 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01036698001 23701986 23776140 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005643 nuclear pore Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01036698001 23701986 23776140 GO:0006606 protein import into nucleus The directed movement of a protein from the cytoplasm to the nucleus. IEA GO:0005643 nuclear pore Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01036698001 23701986 23776140 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005643 nuclear pore Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined. IEA Increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. IEA GO:0005096 GTPase activator activity GSVIVG01036698001 23701986 23776140 GO:0006606 protein import into nucleus The directed movement of a protein from the cytoplasm to the nucleus. IEA GO:0005643 nuclear pore Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined. IEA Increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. IEA GO:0005096 GTPase activator activity GSVIVG01036698001 23701986 23776140 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005643 nuclear pore Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined. IEA The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation. IEA GO:0008083 growth factor activity GSVIVG01036698001 23701986 23776140 GO:0006606 protein import into nucleus The directed movement of a protein from the cytoplasm to the nucleus. IEA GO:0005643 nuclear pore Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined. IEA The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation. IEA GO:0008083 growth factor activity GSVIVG01036698001 23701986 23776140 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005643 nuclear pore Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01036698001 23701986 23776140 GO:0006606 protein import into nucleus The directed movement of a protein from the cytoplasm to the nucleus. IEA GO:0005643 nuclear pore Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01035336001 580315 586970 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01035336001 580315 586970 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01035336001 580315 586970 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end. IEA GO:0008408 3'-5' exonuclease activity GSVIVG01000804001 321009 324921 GSVIVG01018796001 19784091 19787612 GSVIVG01022142001 16917368 16918252 GSVIVG01010674001 11388919 11389194 GSVIVG01000200001 16059687 16067698 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01000200001 16059687 16067698 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01000200001 16059687 16067698 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01000200001 16059687 16067698 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01000200001 16059687 16067698 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01000200001 16059687 16067698 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01000200001 16059687 16067698 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01000200001 16059687 16067698 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01000200001 16059687 16067698 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01000200001 16059687 16067698 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01000200001 16059687 16067698 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01000200001 16059687 16067698 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01000200001 16059687 16067698 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000200001 16059687 16067698 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000200001 16059687 16067698 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01000200001 16059687 16067698 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01000200001 16059687 16067698 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01000200001 16059687 16067698 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01022409001 19787006 19813617 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01022409001 19787006 19813617 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01022409001 19787006 19813617 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01022409001 19787006 19813617 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01022409001 19787006 19813617 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01022409001 19787006 19813617 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01022409001 19787006 19813617 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01022409001 19787006 19813617 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01022409001 19787006 19813617 GO:0046677 response to antibiotic A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01022943001 17728255 17729053 GSVIVG01003110001 7322744 7324362 GSVIVG01033913001 16789886 16790692 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01033913001 16789886 16790692 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01033913001 16789886 16790692 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01020263001 22109309 22113051 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha2-adrenergic receptors; the activity involves transmitting the signal to the Gi alpha subunit of a heterotrimeric G protein. IEA GO:0004938 alpha2-adrenergic receptor activity GSVIVG01020263001 22109309 22113051 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha2-adrenergic receptors; the activity involves transmitting the signal to the Gi alpha subunit of a heterotrimeric G protein. IEA GO:0004938 alpha2-adrenergic receptor activity GSVIVG01020263001 22109309 22113051 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha2-adrenergic receptors; the activity involves transmitting the signal to the Gi alpha subunit of a heterotrimeric G protein. IEA GO:0004938 alpha2-adrenergic receptor activity GSVIVG01020263001 22109309 22113051 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha2-adrenergic receptors; the activity involves transmitting the signal to the Gi alpha subunit of a heterotrimeric G protein. IEA GO:0004938 alpha2-adrenergic receptor activity GSVIVG01020263001 22109309 22113051 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of potassium ions (K+) from one side of a membrane to the other. IEA GO:0015079 potassium ion transmembrane transporter activity GSVIVG01020263001 22109309 22113051 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of potassium ions (K+) from one side of a membrane to the other. IEA GO:0015079 potassium ion transmembrane transporter activity GSVIVG01020263001 22109309 22113051 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of potassium ions (K+) from one side of a membrane to the other. IEA GO:0015079 potassium ion transmembrane transporter activity GSVIVG01020263001 22109309 22113051 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of potassium ions (K+) from one side of a membrane to the other. IEA GO:0015079 potassium ion transmembrane transporter activity GSVIVG01024957001 5674888 5678893 GSVIVG01008880001 3069509 3079601 GSVIVG01008776001 1856439 1864097 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01029064001 11753657 11754177 GSVIVG01028779001 18906219 18911407 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01028779001 18906219 18911407 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01028779001 18906219 18911407 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01028779001 18906219 18911407 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019201001 3650826 3653381 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01019201001 3650826 3653381 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01019201001 3650826 3653381 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01019201001 3650826 3653381 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01004458001 38662433 38669226 GSVIVG01016837001 1789960 1792029 GSVIVG01023749001 10597926 10613592 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. IEA GO:0008080 N-acetyltransferase activity GSVIVG01023278001 20213696 20218463 GSVIVG01010325001 19509484 19511756 GO:0007067 mitosis A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell. IEA GSVIVG01028273001 5172448 5175801 GSVIVG01022800001 16750685 16752537 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01022800001 16750685 16752537 GO:0006865 amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01022800001 16750685 16752537 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. IEA GO:0015171 amino acid transmembrane transporter activity GSVIVG01025548001 14133341 14136582 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025548001 14133341 14136582 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01002813001 36681356 36682390 GSVIVG01026053001 25255970 25258403 GO:0006415 translational termination The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code). IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA A translation release factor that is specific for one or more particular termination codons; acts at the ribosomal A-site and require polypeptidyl-tRNA at the P-site. IEA GO:0016149 translation release factor activity, codon specific GSVIVG01026321001 13912800 13914204 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01003854001 12898423 12902694 GO:0006544 glycine metabolic process The chemical reactions and pathways involving glycine, aminoethanoic acid. IEA Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine. IEA GO:0004372 glycine hydroxymethyltransferase activity GSVIVG01003854001 12898423 12902694 GO:0006563 L-serine metabolic process The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. IEA Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine. IEA GO:0004372 glycine hydroxymethyltransferase activity GSVIVG01023188001 21385777 21388039 GSVIVG01022749001 16040696 16042134 GSVIVG01024503001 3431929 3432018 GSVIVG01029671001 12790596 12792084 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01028981001 16918859 16920865 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019382001 197187 197651 GSVIVG01009834001 11641452 11647885 GSVIVG01018607001 12343319 12344155 Stops, prevents or reduces the activity of an enzyme. IEA GO:0004857 enzyme inhibitor activity GSVIVG01018607001 12343319 12344155 Catalysis of the reaction: pectin + n H2O = n methanol + pectate. IEA GO:0030599 pectinesterase activity GSVIVG01028262001 5013141 5015501 Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01007707001 10163869 10167001 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01020583001 4012378 4069587 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01020583001 4012378 4069587 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01020583001 4012378 4069587 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01020583001 4012378 4069587 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01020583001 4012378 4069587 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01020583001 4012378 4069587 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01020583001 4012378 4069587 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01020583001 4012378 4069587 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01020583001 4012378 4069587 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01020583001 4012378 4069587 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01020583001 4012378 4069587 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01020583001 4012378 4069587 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01020583001 4012378 4069587 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the movement of phospholipids from one membrane face to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP. IEA GO:0004012 phospholipid-translocating ATPase activity GSVIVG01020583001 4012378 4069587 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the movement of phospholipids from one membrane face to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP. IEA GO:0004012 phospholipid-translocating ATPase activity GSVIVG01020583001 4012378 4069587 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the movement of phospholipids from one membrane face to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP. IEA GO:0004012 phospholipid-translocating ATPase activity GSVIVG01020583001 4012378 4069587 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the movement of phospholipids from one membrane face to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP. IEA GO:0004012 phospholipid-translocating ATPase activity GSVIVG01020583001 4012378 4069587 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the movement of phospholipids from one membrane face to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP. IEA GO:0004012 phospholipid-translocating ATPase activity GSVIVG01020583001 4012378 4069587 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the movement of phospholipids from one membrane face to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP. IEA GO:0004012 phospholipid-translocating ATPase activity GSVIVG01020583001 4012378 4069587 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020583001 4012378 4069587 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020583001 4012378 4069587 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020583001 4012378 4069587 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020583001 4012378 4069587 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020583001 4012378 4069587 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020583001 4012378 4069587 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01020583001 4012378 4069587 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01020583001 4012378 4069587 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01020583001 4012378 4069587 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01020583001 4012378 4069587 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01020583001 4012378 4069587 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. IEA GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GSVIVG01020583001 4012378 4069587 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01020583001 4012378 4069587 GO:0006754 ATP biosynthetic process The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01020583001 4012378 4069587 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01020583001 4012378 4069587 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01020583001 4012378 4069587 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01020583001 4012378 4069587 GO:0015914 phospholipid transport The directed movement of phospholipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. IEA GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GSVIVG01031335001 278736 280425 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031335001 278736 280425 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01024276001 487714 491536 Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01024276001 487714 491536 Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01024276001 487714 491536 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01024276001 487714 491536 Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01017706001 2806228 2806473 GSVIVG01020965001 16261283 16265202 GSVIVG01000446001 8080696 8084205 GSVIVG01014218001 1585936 1592494 GO:0006486 protein amino acid glycosylation A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid. IEA GO:0008378 galactosyltransferase activity GSVIVG01023938001 2313915 2331028 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01023938001 2313915 2331028 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. IEA GO:0015238 drug transmembrane transporter activity GSVIVG01023938001 2313915 2331028 GO:0006855 drug transmembrane transport The process whereby a drug is transported from one side of a membrane to the other. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01023938001 2313915 2331028 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. IEA GO:0015297 antiporter activity GSVIVG01012057001 1746065 1747717 GSVIVG01021090001 1357674 1365904 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021090001 1357674 1365904 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01027975001 2919410 2921214 GSVIVG01018141001 6985773 6986088 GO:0009611 response to wounding A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism. IEA Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme. IEA GO:0004867 serine-type endopeptidase inhibitor activity GSVIVG01037611001 6234393 6236285 GSVIVG01011588001 6187968 6190575 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01011588001 6187968 6190575 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01000159001 15744814 15748842 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Interacting selectively and non-covalently with magnesium (Mg) ions. IEA GO:0000287 magnesium ion binding GSVIVG01000159001 15744814 15748842 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01000159001 15744814 15748842 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity. IEA GO:0004721 phosphoprotein phosphatase activity GSVIVG01000159001 15744814 15748842 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. IEA GO:0004722 protein serine/threonine phosphatase activity GSVIVG01000159001 15744814 15748842 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01000159001 15744814 15748842 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01019389001 249700 251327 GSVIVG01012107001 1386743 1417789 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01012107001 1386743 1417789 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01012107001 1386743 1417789 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01012107001 1386743 1417789 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01000081001 3293310 3298480 GO:0016998 cell wall macromolecule catabolic process The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall. IEA GSVIVG01000711001 58790 77083 Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01000711001 58790 77083 Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01031443001 18512705 18537533 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031443001 18512705 18537533 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01031443001 18512705 18537533 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031443001 18512705 18537533 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01031443001 18512705 18537533 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01031443001 18512705 18537533 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01019023001 17631052 17631501 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01019023001 17631052 17631501 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01019023001 17631052 17631501 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019023001 17631052 17631501 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019023001 17631052 17631501 GO:0006457 protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01019023001 17631052 17631501 GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification. IEA Interacting selectively and non-covalently with an unfolded protein. IEA GO:0051082 unfolded protein binding GSVIVG01035816001 4585358 4586699 GSVIVG01021331001 4125738 4129933 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01021331001 4125738 4129933 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01029507001 22175542 22200859 GSVIVG01008326001 3231773 3232558 GSVIVG01003568001 14719508 14731053 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01014501001 4555814 4572521 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014501001 4555814 4572521 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014501001 4555814 4572521 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014501001 4555814 4572521 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014501001 4555814 4572521 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014501001 4555814 4572521 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014501001 4555814 4572521 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014501001 4555814 4572521 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014501001 4555814 4572521 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01014501001 4555814 4572521 GO:0048544 recognition of pollen The process, involving the sharing and interaction of the single locus incompatibility haplotypes, involved in the recognition or rejection of the self pollen by cells in the stigma. This process ensures out-breeding in certain plant species. IEA Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate. IEA GO:0005529 sugar binding GSVIVG01020615001 3732560 3732745 GSVIVG01008730001 1522793 1524300 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01007885001 7936598 7945392 GSVIVG01015370001 3061340 3072065 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01017943001 4934967 4939395 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01017943001 4934967 4939395 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: linoleate + O2 = (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate. IEA GO:0016165 lipoxygenase activity GSVIVG01017943001 4934967 4939395 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor. IEA GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen GSVIVG01017943001 4934967 4939395 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01019691001 2496156 2498001 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01019691001 2496156 2498001 Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. IEA GO:0008171 O-methyltransferase activity GSVIVG01019691001 2496156 2498001 Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01019691001 2496156 2498001 The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. IEA GO:0046983 protein dimerization activity GSVIVG01017179001 5051384 5052701 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01008928001 3446050 3490947 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01028910001 17630578 17633330 GSVIVG01027360001 15798183 15798758 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01027360001 15798183 15798758 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01025176001 3689873 3693429 GO:0009073 aromatic amino acid family biosynthetic process The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). IEA Catalysis of the reaction: 5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. IEA GO:0004107 chorismate synthase activity GSVIVG01037162001 28430031 28430552 GSVIVG01009928001 12468309 12470528 GO:0007186 G-protein coupled receptor protein signaling pathway The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha1-adrenergic receptors; the activity involves transmitting the signal to the Gq alpha subunit of a heterotrimeric G protein. IEA GO:0004937 alpha1-adrenergic receptor activity GSVIVG01004851001 56798 58028 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01020367001 20499083 20500086 GSVIVG01017998001 5357586 5358479 GSVIVG01032118001 22507982 22515439 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01003163001 6071391 6072507 GSVIVG01014720001 8952168 8955081 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GSVIVG01001710001 12545400 12547563 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01001710001 12545400 12547563 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01001710001 12545400 12547563 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01001710001 12545400 12547563 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01033436001 20708032 20708653 GSVIVG01004371001 38254862 38255447 GSVIVG01025315001 2111994 2116254 GSVIVG01011043001 2012594 2017387 GO:0000160 two-component signal transduction system (phosphorelay) A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins. IEA Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. IEA GO:0004871 signal transducer activity GSVIVG01005692001 21271686 21273449 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GSVIVG01028928001 17423020 17425185 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01017678001 2565343 2574143 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01034307001 14584636 14596690 GSVIVG01015151001 1395349 1398302 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01015151001 1395349 1398302 GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01036742001 23111233 23122962 GSVIVG01025511001 148816 156557 GSVIVG01016161001 7300787 7310002 GSVIVG01001503001 5186456 5198077 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01032085001 22880892 22886657 GSVIVG01030514001 6379509 6386017 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01030514001 6379509 6386017 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01030514001 6379509 6386017 GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01026440001 23610770 23623902 Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01026440001 23610770 23623902 Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01026440001 23610770 23623902 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01022217001 17576237 17593347 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01022217001 17576237 17593347 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01022217001 17576237 17593347 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01022217001 17576237 17593347 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01022217001 17576237 17593347 GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein N-ubiquityl(n)lysine = AMP + diphosphate + protein N-ubiquityl(n+1)lysine, i.e. the ligation of ubiquitin moieties, via isopeptide bonds, to extend the length of the multiubiquitin chain attached to a substrate protein. IEA GO:0034450 ubiquitin-ubiquitin ligase activity GSVIVG01022217001 17576237 17593347 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein N-ubiquityl(n)lysine = AMP + diphosphate + protein N-ubiquityl(n+1)lysine, i.e. the ligation of ubiquitin moieties, via isopeptide bonds, to extend the length of the multiubiquitin chain attached to a substrate protein. IEA GO:0034450 ubiquitin-ubiquitin ligase activity GSVIVG01021831001 6773465 6781464 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01021831001 6773465 6781464 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01021831001 6773465 6781464 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01021831001 6773465 6781464 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01026914001 19424386 19429381 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01026914001 19424386 19429381 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01026914001 19424386 19429381 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0030529 ribonucleoprotein complex A macromolecular complex containing both protein and RNA molecules. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01020154001 9730773 9735394 GSVIVG01021635001 8470009 8499830 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01021635001 8470009 8499830 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01021635001 8470009 8499830 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01021635001 8470009 8499830 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01021635001 8470009 8499830 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01032263001 14214325 14218578 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01032263001 14214325 14218578 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01032263001 14214325 14218578 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01032263001 14214325 14218578 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01032263001 14214325 14218578 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027785001 7708103 7713921 GSVIVG01009367001 7834358 7836853 GSVIVG01028520001 9089877 9099995 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01028520001 9089877 9099995 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028520001 9089877 9099995 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01028520001 9089877 9099995 GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01034295001 14301617 14308256 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA Catalysis of the reaction: isopentenyl diphosphate + tRNA = diphosphate + tRNA containing 6-isopentenyladenosine. IEA GO:0004811 tRNA isopentenyltransferase activity GSVIVG01034295001 14301617 14308256 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01012927001 13677843 13680844 GSVIVG01016463001 3654491 3660960 GSVIVG01028970001 17001570 17012208 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01035690001 3367197 3369092 GSVIVG01024232001 96316 98281 Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+. IEA GO:0008121 ubiquinol-cytochrome-c reductase activity GSVIVG01010015001 13476398 13478606 GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA GSVIVG01006785001 28488895 28490402 GSVIVG01016339001 4802824 4810619 GSVIVG01035300001 185878 188582 GSVIVG01015357001 2948392 2950502 GO:0006857 oligopeptide transport The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01015384001 3174019 3179349 GO:0006561 proline biosynthetic process The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015384001 3174019 3179349 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015384001 3174019 3179349 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01015384001 3174019 3179349 GO:0006561 proline biosynthetic process The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins. IEA Catalysis of the reaction: ATP + L-glutamate = ADP + L-glutamate 5-phosphate. IEA GO:0004349 glutamate 5-kinase activity GSVIVG01015384001 3174019 3179349 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: ATP + L-glutamate = ADP + L-glutamate 5-phosphate. IEA GO:0004349 glutamate 5-kinase activity GSVIVG01015384001 3174019 3179349 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: ATP + L-glutamate = ADP + L-glutamate 5-phosphate. IEA GO:0004349 glutamate 5-kinase activity GSVIVG01015384001 3174019 3179349 GO:0006561 proline biosynthetic process The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01015384001 3174019 3179349 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01015384001 3174019 3179349 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01015384001 3174019 3179349 GO:0006561 proline biosynthetic process The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01015384001 3174019 3179349 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01015384001 3174019 3179349 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01034461001 20963970 20970885 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01034461001 20963970 20970885 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01034461001 20963970 20970885 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034461001 20963970 20970885 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01034461001 20963970 20970885 GO:0006915 apoptosis A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01034461001 20963970 20970885 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01016366001 4425609 4433383 GSVIVG01031985001 5919585 5923304 GSVIVG01027712001 13966172 13966744 GSVIVG01036383001 4473614 4500785 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01036383001 4473614 4500785 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain. IEA GO:0004177 aminopeptidase activity GSVIVG01021534001 6733098 6733748 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01021534001 6733098 6733748 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01021534001 6733098 6733748 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01021534001 6733098 6733748 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01021534001 6733098 6733748 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01021534001 6733098 6733748 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01021534001 6733098 6733748 GO:0006350 transcription The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01021534001 6733098 6733748 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01021534001 6733098 6733748 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01008278001 3693770 3695087 GSVIVG01037646001 6519950 6524347 GO:0016192 vesicle-mediated transport The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01011582001 6274423 6285766 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01037739001 7392200 7394238 GO:0015991 ATP hydrolysis coupled proton transport The transport of protons against an electrochemical gradient, using energy from ATP hydrolysis. IEA GO:0033179 proton-transporting V-type ATPase, V0 domain A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring. IEA Catalysis of the transfer of hydrogen ions from one side of a membrane to the other. IEA GO:0015078 hydrogen ion transmembrane transporter activity GSVIVG01032106001 22638288 22638413 GSVIVG01011717001 4822075 4831635 GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. IEA GSVIVG01011717001 4822075 4831635 GO:0009607 response to biotic stimulus A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism. IEA GSVIVG01014762001 9376974 9384076 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01026477001 22947573 22951180 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01026477001 22947573 22951180 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01026477001 22947573 22951180 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01026477001 22947573 22951180 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01026477001 22947573 22951180 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01026477001 22947573 22951180 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the hydrolysis of any glycosyl bond. IEA GO:0016798 hydrolase activity, acting on glycosyl bonds GSVIVG01011637001 5687002 5688994 Catalysis of the transfer of a methyl group to an acceptor molecule. IEA GO:0008168 methyltransferase activity GSVIVG01014974001 13464829 13467295 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. IEA GO:0004364 glutathione transferase activity GSVIVG01033965001 16241062 16244153 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01033965001 16241062 16244153 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01011028001 2100065 2103454 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025279001 2493504 2506478 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0000808 origin recognition complex A multisubunit complex that is located at the replication origins of a chromosome. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025279001 2493504 2506478 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025279001 2493504 2506478 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0000808 origin recognition complex A multisubunit complex that is located at the replication origins of a chromosome. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025279001 2493504 2506478 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025279001 2493504 2506478 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0000808 origin recognition complex A multisubunit complex that is located at the replication origins of a chromosome. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025279001 2493504 2506478 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01025279001 2493504 2506478 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0000808 origin recognition complex A multisubunit complex that is located at the replication origins of a chromosome. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025279001 2493504 2506478 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025279001 2493504 2506478 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0000808 origin recognition complex A multisubunit complex that is located at the replication origins of a chromosome. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025279001 2493504 2506478 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025279001 2493504 2506478 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0000808 origin recognition complex A multisubunit complex that is located at the replication origins of a chromosome. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025279001 2493504 2506478 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01025279001 2493504 2506478 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0000808 origin recognition complex A multisubunit complex that is located at the replication origins of a chromosome. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025279001 2493504 2506478 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025279001 2493504 2506478 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0000808 origin recognition complex A multisubunit complex that is located at the replication origins of a chromosome. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025279001 2493504 2506478 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025279001 2493504 2506478 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0000808 origin recognition complex A multisubunit complex that is located at the replication origins of a chromosome. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025279001 2493504 2506478 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01025279001 2493504 2506478 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0000808 origin recognition complex A multisubunit complex that is located at the replication origins of a chromosome. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025279001 2493504 2506478 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025279001 2493504 2506478 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0000808 origin recognition complex A multisubunit complex that is located at the replication origins of a chromosome. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025279001 2493504 2506478 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025279001 2493504 2506478 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0000808 origin recognition complex A multisubunit complex that is located at the replication origins of a chromosome. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025279001 2493504 2506478 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01025279001 2493504 2506478 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0000808 origin recognition complex A multisubunit complex that is located at the replication origins of a chromosome. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01025279001 2493504 2506478 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01025279001 2493504 2506478 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0000808 origin recognition complex A multisubunit complex that is located at the replication origins of a chromosome. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01025279001 2493504 2506478 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01025279001 2493504 2506478 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0000808 origin recognition complex A multisubunit complex that is located at the replication origins of a chromosome. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01025279001 2493504 2506478 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01025279001 2493504 2506478 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0000808 origin recognition complex A multisubunit complex that is located at the replication origins of a chromosome. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025279001 2493504 2506478 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025279001 2493504 2506478 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0000808 origin recognition complex A multisubunit complex that is located at the replication origins of a chromosome. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025279001 2493504 2506478 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025279001 2493504 2506478 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0000808 origin recognition complex A multisubunit complex that is located at the replication origins of a chromosome. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025279001 2493504 2506478 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01025279001 2493504 2506478 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0000808 origin recognition complex A multisubunit complex that is located at the replication origins of a chromosome. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01025279001 2493504 2506478 GO:0006260 DNA replication The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01025279001 2493504 2506478 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0000808 origin recognition complex A multisubunit complex that is located at the replication origins of a chromosome. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01025279001 2493504 2506478 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01025279001 2493504 2506478 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0000808 origin recognition complex A multisubunit complex that is located at the replication origins of a chromosome. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01025279001 2493504 2506478 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01022224001 17645934 17646217 GSVIVG01025274001 2546270 2553986 GO:0008033 tRNA processing The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01018882001 19007046 19009917 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0004197 cysteine-type endopeptidase activity GSVIVG01018882001 19007046 19009917 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. IEA GO:0008234 cysteine-type peptidase activity GSVIVG01026606001 21120003 21127168 GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA GSVIVG01029258001 17905216 17926009 GO:0006364 rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. IEA GO:0030688 preribosome, small subunit precursor A preribosomal complex consisting of 20S pre-rRNA, ribosomal proteins including late-associating small subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic small ribosomal subunit. IEA Catalysis of the hydrolysis of ester linkages within nucleic acids. IEA GO:0004518 nuclease activity GSVIVG01022644001 14027837 14031363 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01022644001 14027837 14031363 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01032504001 27959216 27967813 GSVIVG01034074001 15372048 15377906 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01034074001 15372048 15377906 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01034074001 15372048 15377906 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01034074001 15372048 15377906 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01034074001 15372048 15377906 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01034074001 15372048 15377906 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01034074001 15372048 15377906 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01034074001 15372048 15377906 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01034074001 15372048 15377906 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01034074001 15372048 15377906 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01034074001 15372048 15377906 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01034074001 15372048 15377906 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01034074001 15372048 15377906 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01034074001 15372048 15377906 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01034074001 15372048 15377906 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01034074001 15372048 15377906 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01034074001 15372048 15377906 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01034074001 15372048 15377906 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01034074001 15372048 15377906 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01034074001 15372048 15377906 GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01034074001 15372048 15377906 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01034074001 15372048 15377906 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0005743 mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01034074001 15372048 15377906 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01034074001 15372048 15377906 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01017090001 4096216 4099147 GSVIVG01018991001 18012560 18022101 Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01018991001 18012560 18022101 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01018991001 18012560 18022101 Interacting selectively and non-covalently with an RNA molecule or a portion thereof. IEA GO:0003723 RNA binding GSVIVG01035079001 1314896 1338433 GSVIVG01013701001 2791840 2794417 GO:0006166 purine ribonucleoside salvage Any process which produces a purine nucleoside from derivatives of it, without de novo synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate or GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate. IEA GO:0004422 hypoxanthine phosphoribosyltransferase activity GSVIVG01013701001 2791840 2794417 GO:0009116 nucleoside metabolic process The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine). IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate or GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate. IEA GO:0004422 hypoxanthine phosphoribosyltransferase activity GSVIVG01013701001 2791840 2794417 GO:0006166 purine ribonucleoside salvage Any process which produces a purine nucleoside from derivatives of it, without de novo synthesis. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01013701001 2791840 2794417 GO:0009116 nucleoside metabolic process The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine). IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01019886001 4231193 4232794 GSVIVG01023837001 3070550 3078772 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01023837001 3070550 3078772 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01016180001 7011657 7018848 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01016180001 7011657 7018848 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01016180001 7011657 7018848 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01016180001 7011657 7018848 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01016180001 7011657 7018848 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Catalysis of the reaction: GTP + H2O = GDP + phosphate. IEA GO:0003924 GTPase activity GSVIVG01016180001 7011657 7018848 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016180001 7011657 7018848 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016180001 7011657 7018848 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016180001 7011657 7018848 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016180001 7011657 7018848 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01016180001 7011657 7018848 GO:0006886 intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01016180001 7011657 7018848 GO:0006913 nucleocytoplasmic transport The directed movement of molecules between the nucleus and the cytoplasm. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01016180001 7011657 7018848 GO:0007165 signal transduction The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01016180001 7011657 7018848 GO:0007264 small GTPase mediated signal transduction Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01016180001 7011657 7018848 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA Interacting selectively and non-covalently with GTP, guanosine triphosphate. IEA GO:0005525 GTP binding GSVIVG01018947001 18450985 18454288 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01018947001 18450985 18454288 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01018947001 18450985 18454288 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01018947001 18450985 18454288 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. IEA GO:0003700 transcription factor activity GSVIVG01018947001 18450985 18454288 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01018947001 18450985 18454288 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. IEA GO:0043565 sequence-specific DNA binding GSVIVG01025610001 13626007 13635209 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). IEA GO:0003777 microtubule motor activity GSVIVG01025610001 13626007 13635209 GO:0007018 microtubule-based movement Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01018296001 11583701 11597378 GO:0006909 phagocytosis The process whereby phagocytes engulf external particulate material. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles. IEA GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. IEA GSVIVG01028897001 17707492 17719297 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01028897001 17707492 17719297 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01028897001 17707492 17719297 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01028897001 17707492 17719297 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01028897001 17707492 17719297 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01027742001 7357237 7358330 GSVIVG01034283001 14050595 14068978 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01034283001 14050595 14068978 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01019296001 1781457 1784560 GO:0006508 proteolysis The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds. IEA Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). IEA GO:0004252 serine-type endopeptidase activity GSVIVG01004107001 14869869 14872716 GSVIVG01024045001 1518982 1524006 GSVIVG01015258001 2163309 2168217 GO:0015031 protein transport The directed movement of proteins into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GSVIVG01015970001 16472080 16483517 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01015970001 16472080 16483517 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01015970001 16472080 16483517 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. IEA GO:0005216 ion channel activity GSVIVG01015970001 16472080 16483517 GO:0006811 ion transport The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01015970001 16472080 16483517 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01015970001 16472080 16483517 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01029183001 18816741 18820448 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01029183001 18816741 18820448 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. IEA GO:0016874 ligase activity GSVIVG01033096001 25679512 25683632 GSVIVG01024010001 1760911 1762467 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01024010001 1760911 1762467 GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01024010001 1760911 1762467 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016020 membrane Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01024010001 1760911 1762467 GO:0055085 transmembrane transport The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute. IEA GO:0016021 integral to membrane Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. IEA Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. IEA GO:0005215 transporter activity GSVIVG01028171001 4390893 4392246 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01006683001 27481614 27484939 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01006683001 27481614 27484939 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01006683001 27481614 27484939 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01006683001 27481614 27484939 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01028861001 18026548 18029340 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans. IEA GO:0004650 polygalacturonase activity GSVIVG01037617001 6270717 6280019 GSVIVG01016995001 3253671 3276089 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01016995001 3253671 3276089 GO:0006470 protein amino acid dephosphorylation The process of removing one or more phosphoric residues from a protein. IEA GO:0008287 protein serine/threonine phosphatase complex A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. IEA Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. IEA GO:0004722 protein serine/threonine phosphatase activity GSVIVG01021526001 6641926 6647215 GSVIVG01021983001 4723496 4730896 GO:0006334 nucleosome assembly The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. IEA GO:0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01024353001 1339890 1341224 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01003280001 14082717 14084070 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01003280001 14082717 14084070 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0031361 integral to thylakoid membrane Penetrating at least one phospholipid bilayer of a thylakoid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01003280001 14082717 14084070 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01003280001 14082717 14084070 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01003280001 14082717 14084070 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0031361 integral to thylakoid membrane Penetrating at least one phospholipid bilayer of a thylakoid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01003280001 14082717 14084070 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01003280001 14082717 14084070 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01003280001 14082717 14084070 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA GO:0031361 integral to thylakoid membrane Penetrating at least one phospholipid bilayer of a thylakoid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01003280001 14082717 14084070 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01003280001 14082717 14084070 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01003280001 14082717 14084070 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0031361 integral to thylakoid membrane Penetrating at least one phospholipid bilayer of a thylakoid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01003280001 14082717 14084070 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01003280001 14082717 14084070 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01003280001 14082717 14084070 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0031361 integral to thylakoid membrane Penetrating at least one phospholipid bilayer of a thylakoid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01003280001 14082717 14084070 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01003280001 14082717 14084070 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01003280001 14082717 14084070 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0031361 integral to thylakoid membrane Penetrating at least one phospholipid bilayer of a thylakoid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01003280001 14082717 14084070 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01003280001 14082717 14084070 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01003280001 14082717 14084070 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA GO:0031361 integral to thylakoid membrane Penetrating at least one phospholipid bilayer of a thylakoid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01003280001 14082717 14084070 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01003280001 14082717 14084070 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01003280001 14082717 14084070 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0031361 integral to thylakoid membrane Penetrating at least one phospholipid bilayer of a thylakoid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01003280001 14082717 14084070 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01003280001 14082717 14084070 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01003280001 14082717 14084070 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0031361 integral to thylakoid membrane Penetrating at least one phospholipid bilayer of a thylakoid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01003280001 14082717 14084070 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01003280001 14082717 14084070 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01003280001 14082717 14084070 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0031361 integral to thylakoid membrane Penetrating at least one phospholipid bilayer of a thylakoid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01003280001 14082717 14084070 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01003280001 14082717 14084070 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01003280001 14082717 14084070 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA GO:0031361 integral to thylakoid membrane Penetrating at least one phospholipid bilayer of a thylakoid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01003280001 14082717 14084070 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01003280001 14082717 14084070 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01003280001 14082717 14084070 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0031361 integral to thylakoid membrane Penetrating at least one phospholipid bilayer of a thylakoid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01003280001 14082717 14084070 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01003280001 14082717 14084070 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01003280001 14082717 14084070 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0031361 integral to thylakoid membrane Penetrating at least one phospholipid bilayer of a thylakoid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01003280001 14082717 14084070 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01003280001 14082717 14084070 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01003280001 14082717 14084070 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0031361 integral to thylakoid membrane Penetrating at least one phospholipid bilayer of a thylakoid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01003280001 14082717 14084070 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01003280001 14082717 14084070 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01003280001 14082717 14084070 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA GO:0031361 integral to thylakoid membrane Penetrating at least one phospholipid bilayer of a thylakoid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01003280001 14082717 14084070 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01003280001 14082717 14084070 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01003280001 14082717 14084070 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0031361 integral to thylakoid membrane Penetrating at least one phospholipid bilayer of a thylakoid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01003280001 14082717 14084070 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01003280001 14082717 14084070 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01003280001 14082717 14084070 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0031361 integral to thylakoid membrane Penetrating at least one phospholipid bilayer of a thylakoid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01003280001 14082717 14084070 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01003280001 14082717 14084070 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01003280001 14082717 14084070 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0031361 integral to thylakoid membrane Penetrating at least one phospholipid bilayer of a thylakoid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01003280001 14082717 14084070 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01003280001 14082717 14084070 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01003280001 14082717 14084070 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA GO:0031361 integral to thylakoid membrane Penetrating at least one phospholipid bilayer of a thylakoid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01003280001 14082717 14084070 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01003280001 14082717 14084070 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01003280001 14082717 14084070 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0031361 integral to thylakoid membrane Penetrating at least one phospholipid bilayer of a thylakoid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01003280001 14082717 14084070 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01003280001 14082717 14084070 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01003280001 14082717 14084070 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0031361 integral to thylakoid membrane Penetrating at least one phospholipid bilayer of a thylakoid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01003280001 14082717 14084070 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01003280001 14082717 14084070 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01003280001 14082717 14084070 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0031361 integral to thylakoid membrane Penetrating at least one phospholipid bilayer of a thylakoid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01003280001 14082717 14084070 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01003280001 14082717 14084070 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01003280001 14082717 14084070 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA GO:0031361 integral to thylakoid membrane Penetrating at least one phospholipid bilayer of a thylakoid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01003280001 14082717 14084070 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01003280001 14082717 14084070 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01003280001 14082717 14084070 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0031361 integral to thylakoid membrane Penetrating at least one phospholipid bilayer of a thylakoid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01003280001 14082717 14084070 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01003280001 14082717 14084070 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01003280001 14082717 14084070 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0031361 integral to thylakoid membrane Penetrating at least one phospholipid bilayer of a thylakoid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01003280001 14082717 14084070 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01003280001 14082717 14084070 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01003280001 14082717 14084070 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0031361 integral to thylakoid membrane Penetrating at least one phospholipid bilayer of a thylakoid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01003280001 14082717 14084070 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01003280001 14082717 14084070 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01003280001 14082717 14084070 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA GO:0031361 integral to thylakoid membrane Penetrating at least one phospholipid bilayer of a thylakoid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01003280001 14082717 14084070 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01003280001 14082717 14084070 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01003280001 14082717 14084070 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0031361 integral to thylakoid membrane Penetrating at least one phospholipid bilayer of a thylakoid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01003280001 14082717 14084070 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan. IEA GO:0016762 xyloglucan:xyloglucosyl transferase activity GSVIVG01003280001 14082717 14084070 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01003280001 14082717 14084070 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0031361 integral to thylakoid membrane Penetrating at least one phospholipid bilayer of a thylakoid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01003280001 14082717 14084070 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01003280001 14082717 14084070 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01003280001 14082717 14084070 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0031361 integral to thylakoid membrane Penetrating at least one phospholipid bilayer of a thylakoid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01003280001 14082717 14084070 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01003280001 14082717 14084070 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01003280001 14082717 14084070 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA GO:0031361 integral to thylakoid membrane Penetrating at least one phospholipid bilayer of a thylakoid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01003280001 14082717 14084070 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01003280001 14082717 14084070 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01003280001 14082717 14084070 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0031361 integral to thylakoid membrane Penetrating at least one phospholipid bilayer of a thylakoid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01003280001 14082717 14084070 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01003280001 14082717 14084070 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01003280001 14082717 14084070 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0031361 integral to thylakoid membrane Penetrating at least one phospholipid bilayer of a thylakoid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01003280001 14082717 14084070 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01003280001 14082717 14084070 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01003280001 14082717 14084070 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0031361 integral to thylakoid membrane Penetrating at least one phospholipid bilayer of a thylakoid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01003280001 14082717 14084070 GO:0006073 cellular glucan metabolic process The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01003280001 14082717 14084070 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01003280001 14082717 14084070 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA GO:0031361 integral to thylakoid membrane Penetrating at least one phospholipid bilayer of a thylakoid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01003280001 14082717 14084070 GO:0015074 DNA integration The process by which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01003280001 14082717 14084070 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0005618 cell wall The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01003280001 14082717 14084070 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0031361 integral to thylakoid membrane Penetrating at least one phospholipid bilayer of a thylakoid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01003280001 14082717 14084070 GO:0015979 photosynthesis The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds. IEA GO:0048046 apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it. IEA Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01015611001 14042271 14064861 GSVIVG01021072001 14128823 14143945 GO:0045449 regulation of transcription Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01019393001 279462 280511 GSVIVG01020441001 19354126 19365820 GSVIVG01017545001 10322798 10323844 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01019804001 3470705 3475501 Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01019804001 3470705 3475501 Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0004386 helicase activity GSVIVG01019804001 3470705 3475501 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01019804001 3470705 3475501 Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. IEA GO:0008026 ATP-dependent helicase activity GSVIVG01013545001 20493929 20499367 GO:0006813 potassium ion transport The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore. IEA GO:0008076 voltage-gated potassium channel complex A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. IEA Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel. IEA GO:0005249 voltage-gated potassium channel activity GSVIVG01036140001 20235760 20236820 GSVIVG01003699001 15281915 15283172 GSVIVG01020482001 18712458 18722886 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020482001 18712458 18722886 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. IEA GO:0000166 nucleotide binding GSVIVG01020482001 18712458 18722886 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01020482001 18712458 18722886 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01020482001 18712458 18722886 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with single-stranded DNA. IEA GO:0003697 single-stranded DNA binding GSVIVG01020482001 18712458 18722886 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with single-stranded DNA. IEA GO:0003697 single-stranded DNA binding GSVIVG01020482001 18712458 18722886 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020482001 18712458 18722886 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01020482001 18712458 18722886 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate in the presence of single- or double-stranded DNA; drives another reaction. IEA GO:0008094 DNA-dependent ATPase activity GSVIVG01020482001 18712458 18722886 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: ATP + H2O = ADP + phosphate in the presence of single- or double-stranded DNA; drives another reaction. IEA GO:0008094 DNA-dependent ATPase activity GSVIVG01020482001 18712458 18722886 GO:0006259 DNA metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01020482001 18712458 18722886 GO:0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. IEA GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. IEA Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. IEA GO:0017111 nucleoside-triphosphatase activity GSVIVG01025128001 4180823 4182134 GSVIVG01000330001 11437314 11437938 GSVIVG01037516001 12398607 12405407 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01037516001 12398607 12405407 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with any nucleic acid. IEA GO:0003676 nucleic acid binding GSVIVG01037516001 12398607 12405407 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01037516001 12398607 12405407 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid). IEA GO:0003677 DNA binding GSVIVG01037516001 12398607 12405407 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0000785 chromatin The ordered and organized complex of DNA and protein that forms the chromosome. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01037516001 12398607 12405407 GO:0006355 regulation of transcription, DNA-dependent Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription. IEA GO:0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. IEA Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01017967001 5127093 5134133 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. IEA GO:0016787 hydrolase activity GSVIVG01018943001 18499216 18507148 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. IEA GO:0004842 ubiquitin-protein ligase activity GSVIVG01018943001 18499216 18507148 GO:0016567 protein ubiquitination The process by which one or more ubiquitin moieties are added to a protein. IEA GO:0000151 ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01030993001 20464228 20465978 GO:0019538 protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification. IEA Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide. IEA GO:0016671 oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor GSVIVG01030993001 20464228 20465978 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide. IEA GO:0016671 oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor GSVIVG01012395001 386185 389912 GSVIVG01010479001 20935036 20939592 GO:0007067 mitosis A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell. IEA GSVIVG01017617001 2038619 2053444 GSVIVG01021425001 5216166 5226384 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021425001 5216166 5226384 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021425001 5216166 5226384 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021425001 5216166 5226384 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01021425001 5216166 5226384 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01021425001 5216166 5226384 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. IEA GO:0016740 transferase activity GSVIVG01021425001 5216166 5226384 GO:0006633 fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01021425001 5216166 5226384 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01021425001 5216166 5226384 GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. IEA Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). IEA GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GSVIVG01035384001 915980 921064 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. IEA GO:0004497 monooxygenase activity GSVIVG01035384001 915980 921064 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with iron (Fe) ions. IEA GO:0005506 iron ion binding GSVIVG01035384001 915980 921064 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. IEA GO:0009055 electron carrier activity GSVIVG01035384001 915980 921064 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. IEA GO:0020037 heme binding GSVIVG01033641001 19018030 19024637 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the hydrolysis of any O-glycosyl bond. IEA GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GSVIVG01004950001 16960673 16961227 GSVIVG01037413001 14190688 14193148 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). IEA GO:0016758 transferase activity, transferring hexosyl groups GSVIVG01032405001 27065162 27065714 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01032405001 27065162 27065714 GO:0006412 translation The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome. IEA GO:0005840 ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. IEA The action of a molecule that contributes to the structural integrity of the ribosome. IEA GO:0003735 structural constituent of ribosome GSVIVG01022100001 16584213 16585911 Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. IEA GO:0008171 O-methyltransferase activity GSVIVG01013466001 228252 232731 GSVIVG01014930001 12182025 12203641 GSVIVG01016021001 17458465 17458758 GSVIVG01027524001 15988636 15991601 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01027524001 15988636 15991601 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01027524001 15988636 15991601 Interacting selectively and non-covalently with any metal ion. IEA GO:0046872 metal ion binding GSVIVG01001943001 15119260 15122467 The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01012123001 1241082 1242515 GSVIVG01021872001 6231170 6237009 GO:0006535 cysteine biosynthetic process from serine The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021872001 6231170 6237009 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01021872001 6231170 6237009 GO:0006535 cysteine biosynthetic process from serine The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine. IEA Catalysis of the reaction: O3-acetyl-L-serine + H2S = L-cysteine + acetate. IEA GO:0004124 cysteine synthase activity GSVIVG01021872001 6231170 6237009 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: O3-acetyl-L-serine + H2S = L-cysteine + acetate. IEA GO:0004124 cysteine synthase activity GSVIVG01021872001 6231170 6237009 GO:0006535 cysteine biosynthetic process from serine The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01021872001 6231170 6237009 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. IEA GO:0030170 pyridoxal phosphate binding GSVIVG01037084001 29311049 29315400 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01026578001 21469069 21469866 GSVIVG01010370001 19888622 19890374 Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01037142001 28686085 28689667 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). IEA GO:0005515 protein binding GSVIVG01037142001 28686085 28689667 Interacting selectively and non-covalently with zinc (Zn) ions. IEA GO:0008270 zinc ion binding GSVIVG01029228001 18296758 18298250 GSVIVG01014231001 1727940 1733497 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01014231001 1727940 1733497 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01014231001 1727940 1733497 GO:0006099 tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01014231001 1727940 1733497 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01014231001 1727940 1733497 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01014231001 1727940 1733497 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01014231001 1727940 1733497 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. IEA GO:0003824 catalytic activity GSVIVG01014231001 1727940 1733497 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01014231001 1727940 1733497 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01014231001 1727940 1733497 GO:0006099 tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01014231001 1727940 1733497 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01014231001 1727940 1733497 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01014231001 1727940 1733497 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01014231001 1727940 1733497 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. IEA GO:0005488 binding GSVIVG01014231001 1727940 1733497 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01014231001 1727940 1733497 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01014231001 1727940 1733497 GO:0006099 tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01014231001 1727940 1733497 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01014231001 1727940 1733497 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01014231001 1727940 1733497 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01014231001 1727940 1733497 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. IEA GO:0016491 oxidoreductase activity GSVIVG01014231001 1727940 1733497 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. IEA GO:0016615 malate dehydrogenase activity GSVIVG01014231001 1727940 1733497 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. IEA GO:0016615 malate dehydrogenase activity GSVIVG01014231001 1727940 1733497 GO:0006099 tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. IEA Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. IEA GO:0016615 malate dehydrogenase activity GSVIVG01014231001 1727940 1733497 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. IEA GO:0016615 malate dehydrogenase activity GSVIVG01014231001 1727940 1733497 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. IEA GO:0016615 malate dehydrogenase activity GSVIVG01014231001 1727940 1733497 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. IEA GO:0016615 malate dehydrogenase activity GSVIVG01014231001 1727940 1733497 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. IEA GO:0016615 malate dehydrogenase activity GSVIVG01014231001 1727940 1733497 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01014231001 1727940 1733497 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01014231001 1727940 1733497 GO:0006099 tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01014231001 1727940 1733497 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01014231001 1727940 1733497 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01014231001 1727940 1733497 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01014231001 1727940 1733497 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. IEA GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GSVIVG01014231001 1727940 1733497 GO:0005975 carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. IEA Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids. IEA GO:0030060 L-malate dehydrogenase activity GSVIVG01014231001 1727940 1733497 GO:0006096 glycolysis The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle. IEA Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids. IEA GO:0030060 L-malate dehydrogenase activity GSVIVG01014231001 1727940 1733497 GO:0006099 tricarboxylic acid cycle A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. IEA Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids. IEA GO:0030060 L-malate dehydrogenase activity GSVIVG01014231001 1727940 1733497 GO:0006108 malate metabolic process The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle. IEA Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids. IEA GO:0030060 L-malate dehydrogenase activity GSVIVG01014231001 1727940 1733497 GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. IEA Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids. IEA GO:0030060 L-malate dehydrogenase activity GSVIVG01014231001 1727940 1733497 GO:0044262 cellular carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells. IEA Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids. IEA GO:0030060 L-malate dehydrogenase activity GSVIVG01014231001 1727940 1733497 GO:0055114 oxidation reduction The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons. IEA Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids. IEA GO:0030060 L-malate dehydrogenase activity GSVIVG01014070001 85758 88311 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. IEA GO:0004672 protein kinase activity GSVIVG01014070001 85758 88311 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. IEA GO:0004674 protein serine/threonine kinase activity GSVIVG01014070001 85758 88311 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. IEA GO:0004713 protein tyrosine kinase activity GSVIVG01014070001 85758 88311 GO:0006468 protein amino acid phosphorylation The process of introducing a phosphate group on to a protein. IEA Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. IEA GO:0005524 ATP binding GSVIVG01014416001 3567926 3574374 GSVIVG01008871001 2924980 2926780